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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 2. Отображено 2.
07-04-2023 дата публикации

EZH2 and BRD4 double-target inhibitor and application thereof

Номер: CN115920073A
Автор: WEN SHIJUN, HUANG PENG, SUN YAMENG, GUO ZHIRONG, WU ZHOUMING
Принадлежит:

The invention discloses an EZH2 and BRD4 double-target inhibitor and application thereof. The double-target inhibitor is obtained by coupling a structural fragment for inhibiting a BRD4 protein and a structural fragment for inhibiting an EZH2 protein through a linker. The inventor finds that a structural fragment for inhibiting EZH2 protein and a structural fragment for inhibiting BRD4 protein are structurally modified and coupled together through a linker, the length of the linker is adjusted, the obtained EZH2 and BRD4 double-target inhibitor has an unexpected anti-tumor effect, and the anti-tumor effect of the EZH2 and BRD4 double-target inhibitor is superior to that of a single EZH2 inhibitor or a single BRD4 inhibitor and is also superior to that of combination of the EZH2 inhibitor and the BRD4 inhibitor under the same condition.

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Номер записи: 1
05-05-2023 дата публикации

Application of substance for detecting LOXL1 gene mutation in preparation of product for molecular typing of hepatic fibrosis patients

Номер: CN116064765A
Автор: CHEN WEI, YOU HONG, SUN YAMENG, ZHANG WEN, CHEN SHUYAN, ZHANG NING
Принадлежит:

The invention discloses application of a substance for detecting LOXL1 gene mutation in preparation of a product for molecular typing of a hepatic fibrosis patient. The invention discloses application of a substance for detecting LOXL1 gene mutation in preparation of a product for molecular typing of a hepatic fibrosis patient. The LOXL1 gene mutation is heterozygous mutation that the 458th nucleotide of a first exon of the LOXL1 gene is mutated from G to A from an initiation codon ATG. According to the invention, the LOXL1 gene 458Ggt is found for the first time; the GA heterozygous mutation is obviously related to the difficulty in reversion of hepatic fibrosis after treatment of hepatic fibrosis patients, and based on the discovery, molecular typing can be quickly performed on the initial treatment patients of hepatic fibrosis so as to pre-judge the post-treatment effect, so that better supervision and management on the hepatic fibrosis patients in the clinical diagnosis and treatment ...

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Номер записи: 2