Fuziline esterification derivative, synthetic method and use

The invention discloses a preparation method of a derivative (with a compound structure shown as the picture) of fuziline in a natural diterpenoid alkaloid of aconitum plants and an application thereof, pertaining to the technical field of medical and pesticide synthesis. The preparation method of the compound derivate comprises the steps that the fuziline is dissolved in a dry pyridine and subjected to alkaline treatment, chloroform extraction and steaming and concentration after being added with a sulfate reagent for a chemical reaction, thus obtaining the sulfated derivative; and a crude product can be purified by the method of recrystallization or column chromatography. The synthesizing method is simple and convenient and has relatively low cost and high transformation rate. The compound synthesized has relatively high biological activity and can be used for developing new products such as medicines, pesticides, etc. In the formula, R1 refers to alkanoyl, fatty acyl or aromaticacyl ...

Formononetin-3'-sodium sulfonate, prunetin-3'-sodium sulfonate and their preparation process and medicinal use

Preparation of aconite primary diterpene alkaloid component and use in disinsection

The invention relates to a method for preparing main diterpenoid alkaloids of radix aconiti carmichaeli by means of extraction and separation from crude radix aconiti carmichaeli of the traditional Chinese medicine and a desinsection application thereof, pertaining to the technical field of the preparation of a natural active ingredient and the application thereof. The preparation method for the main diterpenoid alkaloids of the crude radix aconiti carmichaeli comprises the steps that the Mianyang radix aconiti carmichaeli is taken as a raw material which is extracted by ethanol after being dried and ground, then subjected to acid and alkali treatment and is leached by an organic solvent (such as chloroform, acetic ether, and the like) to obtain the general diterpenoid alkaloids; and the general diterpenoid alkaloid obtained is subjected to silica gel column chromatography and separation and then the main diterpenoid alkaloids are obtained through recrystallization. The main diterpenoid ...

Extraction and purification method of saikosaponin

The invention discloses an extraction and purification method of saikosaponin. The saponin part mainly contains saikosaponin a and saikosaponin d. The extract can be prepared by using a percolation method or a high-pressure percolation method, an ethanol solution is used for extracting bupleurum medicinal material, macroporous resin is used for purifying in the purification process, the total weight of the saikosaponin a and saikosaponin d in the prepared saikosaponin extract accounts for 30-60% of the weight of the extract, and the weight of the total saponins accounts for 50-80% of the weight of the extract. The method disclosed by the invention is simple to operate, has the advantages of low production cost, energy saving and high extraction efficiency, and is suitable for industrialized production.

Extraction and purification method of saikosaponin

The invention discloses an extraction and purification method of saikosaponin. The saponin part mainly contains saikosaponin a and saikosaponin d. The extract can be prepared by using a percolation method or a high-pressure percolation method, an ethanol solution is used for extracting bupleurum medicinal material, macroporous resin is used for purifying in the purification process, the total weight of the saikosaponin a and saikosaponin d in the prepared saikosaponin extract accounts for 30-60% of the weight of the extract, and the weight of the total saponins accounts for 50-80% of the weight of the extract. The method disclosed by the invention is simple to operate, has the advantages of low production cost, energy saving and high extraction efficiency, and is suitable for industrialized production.

Process for preparing bupleurum chinense injection

The invention discloses a method for preparing a bupleurum chinense injection. A process for preparing the bupleurum chinense injection comprises the following steps of: extracting a supercritical product taking a bupleurum chinense volatile oil as a main component by using a CO<2> supercritical extraction technique; purifying the supercritical product by a distillation method; and after adding an HP-Beta-CD into the obtained distillate for cladding, adding a corresponding pharmaceutical adjuvant to prepare the bupleurum chinense injection. The process for preparing the bupleurum chinense injection provided by the invention can correctly perform qualitative and quantitative analysis on the volatile oil which is contained in a medicament, and meanwhile, can increase the yield of the bupleurum chinense volatile oil, improve the dissolubility of the bupleurum chinense volatile oil, increase the stability of the medicament, promote medicament absorption and improve bioavailability on the basis ...

Process for preparing bupleurum chinense injection

The present invention discloses a method for preparing a bupleurum chinense injection. A process for preparing the bupleurum chinense injection comprises the following steps of: extracting a supercritical product taking a bupleurum chinense volatile oil as a main component by using a CO<2> supercritical extraction technique; purifying the supercritical product by a distillation method; and after adding an HP-Beta-CD into the obtained distillate for cladding, adding a corresponding pharmaceutical adjuvant to prepare the bupleurum chinense injection. The process for preparing the bupleurum chinense injection provided by the invention can correctly perform qualitative and quantitative analysis on the volatile oil which is contained in a medicament, and meanwhile, can increase the yield of the bupleurum chinense volatile oil, improve the dissolubility of the bupleurum chinense volatile oil, increase the stability of the medicament, promote medicament absorption and improve bioavailability on ...