24-07-2014 дата публикации
Номер: US20140206605A1
Принадлежит:
The present invention relates to different forms of a HCV inhibitory compound. 1. Compound A having a form selected from the group consisting of:{'sub': 'α', 'a) Hydrate III, wherein Hydrate III is characterized by either (i) an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 20.5, 5.0, and 18.2; or (ii) a solid state carbon-13 CPMAS NMR comprising peaks at about 5.14, 6.31, 12.49, 18.35, 26.81, 28.03, 30.33, 31.27, 34.95, 35.99, 38.68, 42.01, 54.93, 56.39, 60.14, 74.20, 107.02, 120.11, 121.60, 129.73, 134.35, 135.95, 142.89, 148.47, 155.37, 157.32, 160.90, 168.32, 172.17, and 175.53 ppm;'}{'sub': 'α', 'b) Hydrate II, wherein Hydrate II is characterized by an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 11.7, 16.6, and 11.2;'}{'sub': 'α', 'c) a crystalline Na salt characterized by an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 18.4, 9.1, and 9.8;'}{'sub': 'α', 'd) a crystalline K salt characterized by an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 18.2, 8.9, and 20.3;'}{'sub': 'α', 'e) Hydrate I, wherein Hydrate I is characterized by either (i) an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 8.6, 20.6, and 26.6; or (ii) a solid state carbon-13 CPMAS NMR comprising peaks at about 4.22, 7.23, 11.45, 17.79, 24.04, 26.95, 28.29, 31.15, 32.47, 32.47, 33.46, 34.03, 35.74, 42.32, 53.50, 56.05, 56.96, 77.49, 108.95, 119.65, 122.55, 131.05, 133.13, 135.38, 142.28, 150.78, 156.03, 157.99, 161.36, 171.40, 173.42, 174.30 ppm;'}{'sub': 'α', 'f) Hydrate IV, wherein Hydrate IV is characterized by either (i) an X-ray powder diffraction pattern obtained using copper K radiation which comprises 2Θ values in degrees of about 14.7, 11.5, and 7.1; or (ii ...
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