SIGNAL PROCESSING FOR MASS DIRECTED FRACTION COLLECTION

A system and removing noise from a mass spectrometer signal for fraction collection is described herein. 1. A system for performing fraction collection , the system comprising:a fluid delivery device configured to deliver an eluent containing a substance of interest from a liquid chromatography system;a splitter device configured to cause a first portion of the eluent to be directed to a mass spectrometer and a second portion of the eluent to be directed to a collection device; analyze the eluent using the mass spectrometer to obtain a raw signal;', 'calculate a baseline signal based on the raw signal acquired during a time window subsequent to signal collection and prior to an expected signal peak,', 'process the raw signal in real time to generate a processed signal prior to the eluent corresponding to the processed signal reaching the collection device, the processed signal removing at least some noise from the raw signal including subtracting the baseline signal from the raw signal; and', 'select portions of the eluent to collect by the collection device based on the processed signal., 'a processor configured to2. The system of claim 1 , further comprising configurations to:recalculate a new baseline signal based on the raw signal acquired during a time window between adjacent signal peaks; andsubsequent to recalculating the new baseline signal, subtract the new baseline signal from the raw signal to generate the processed signal.3. The system of claim 1 , the configurations to process the raw signal to generate a processed signal comprise configurations to apply a triangle filter to the raw signal to generate the processed signal.4. The system of claim 1 , wherein the configurations to process the raw signal to generate a processed signal comprise configurations to apply a box filter to the raw signal to generate the processed signal.5. The system of claim 1 , wherein the configurations to process the raw signal to generate a processed signal comprise ...

Nucleic acid integrated detection method and detection reagent tube

Nucleic acid integrated detection method and detection reagent tube

Disclosed are a nucleic acid integrated detection method and detection reagent tube. A plurality of separators are vertically arranged within a main tube, and a liquid phase or solid phase hydrophobic layer is arranged on each separator, so as to isolate a lysis solution, a cleaning solution and a reaction solution within the detection reagent tube. A sample is added to the lysis solution for mixing and lysis, nano-magnetic beads are used to extract nucleic acid in the sample, an external magnetic body is used to drive the nano-magnetic beads to carry the nucleic acid along magnetic bead channels on an inner wall of the detection reagent tube to sequentially pass through the hydrophobic layers to enter the cleaning solution and the reaction solution for cleaning and amplification of the nucleic acid, a biological reagent required for the reaction solution being stored in the separator above the reaction solution, and finally an external device performs detection on the sample nucleic acid ...

Sequence selection for non-orthogonal multiple access transmissions

Optimizing the resource configuration or selection for grant-free contention-based non-orthogonal multiple access (NOMA) transmissions is an effective way to increase network capacity and reduce multi-user interference at the user equipment (UE). In some embodiments, a network node may determine the current traffic load, select multiple access (MA) sequences for the UE based on the determination, and transmit this selection to the UE for subsequent transmissions. In other embodiments, the UE may receive a message with an indication of the traffic load being experienced by the base station that the UE is attempting to connect to, and then may randomly select an MA sequence for subsequent transmissions.

Face modification tool

One or more embodiments of the invention provide a method, apparatus, system, and article of manufacture for modifying a three-dimensional model. A composite three-dimensional model is displayed in a computer implemented solid modeling system. The composite model comprises a first primitive and a second primitive. A first face of the first primitive is selected. Once selected, a first boundary representation of the first primitive is modified using the selected first face. Thereafter, a second boundary representation of the second primitive is automatically modified based on the modification to the first boundary representation.

SEQUENCE SELECTION FOR NON-ORTHOGONAL MULTIPLE ACCESS TRANSMISSIONS

Optimizing the resource configuration or selection for grant-free contention-based non-orthogonal multiple access (NOMA) transmissions is an effective way to increase network capacity and reduce multi-user interference at the user equipment (UE). In some embodiments, a network node may determine the current traffic load, select multiple access (MA) sequences for the UE based on the determination, and transmit this selection to the UE for subsequent transmissions. In other embodiments, the UE may receive a message with an indication of the traffic load being experienced by the base station that the UE is attempting to connect to, and then may randomly select an MA sequence for subsequent transmissions.

Method and apparatus for generating spreading sequence codebooks

A method and apparatus for generating and utilizing spreading sequence codebooks for a symbol-level sequence spreading is disclosed. In one embodiment, a method performed by a wireless communication device, comprising: receiving a first number from a wireless communication node; selecting a first spreading sequence codebook from at least one spreading sequence codebook; selecting a first spreading sequence from the first spreading sequence codebook according to the first number; and spreading data symbols according to the first spreading sequence, wherein the at least one spreading sequence codebook each comprises a plurality of spreading sequences configured based on one entry of a first sequence set after cyclic shifting operation, wherein the first sequence set before cyclic shifting operation is configured based on a second sequence set.

Method for designing refiner plates with three-stage radial curved bars

The present invention discloses a method for designing a refiner plate with three-stage radial curved bars, comprising following steps of: designing a circle arc for 1ststage radial curved bars; designing a circle arc for the 2ndstage radial curved bars; designing a circle arc for 3rdstage radial curved bars; and designing a center angle for the refiner plate according to the size of the refiner plate and the manufacture requirements, to complete the design of the refiner plate. In the present invention, by the establishment of equations for the circle arcs and angles of inclination of the curved bars, it is ensured that the width of the bars will not change in the radial direction, and both the flexibility in designing a curved refiner plate and the uniformity of crushing are improved. This design method provides a theory basis and also instructions for designing multi-stage radial curved bars.

Immuno-amplification

A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. In one embodiment, target-independent amplicon formation is prevented by using hybridization blocker oligonucleotides that bind oligonucleotide moieties that are not hybridized ...

Method for designing refiner plates with equidistant curved bars

The present invention discloses a method for designing a refiner plate with equidistant curved bars, comprising following steps of: designing a central bar are of center curved bar and defining the bar angle for the equidistant curved bar; designing circle arcs for curved bars on two sides of center curved bar of equidistant curved bar segment; when the whole refining segment is full of circle arcs, trimming lines of outer circle arcs of the refining segment to complete the design of equidistant circle arcs on the two sides; and if required, dividing the bars into zones. In the present invention, by the definition of the bar angle for the curved bars and the parametric design of the equidistant curved bars by using circle are equations, it is ensured that the flexibility in designing an equidistant curved bar refiner plate is improved.

Random-access sending and receiving method and apparatus, transmitting end and receiving end

Provided are a random-access sending and receiving method and apparatus, transmitting end, receiving end, and storage medium. The random-access sending method includes: a preamble resource is acquired, and preamble information is generated; a pilot resource is determined according to the preamble resource and a user equipment identifier, and pilot information is generated; data information is acquired, and the data information is mapped to a time-frequency resource, the data information including user equipment identifier information; and a radio frame is formed from the preamble information, the pilot information and the data information, and the radio frame is sent.

Nucleic acid integrated detection method and detection reagent tube

A nucleic acid integrated detection method and detection reagent tube are provided, separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube.

Face modification tool

One or more embodiments of the invention provide a method, apparatus, system, and article of manufacture for modifying a three-dimensional model. A composite three-dimensional model is displayed in a computer implemented solid modeling system. The composite model comprises a first primitive and a second primitive. A first face of the first primitive is selected. Once selected, a first boundary representation of the first primitive is modified using the selected first face. Thereafter, a second boundary representation of the second primitive is automatically modified based on the modification to the first boundary representation.

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Experimental system for studying refining mechanism and characteristic of refiner plate and method for operating same

An experimental system for studying a refining mechanism and characteristic of a refiner plate, including a disc refiner unit, a first storage tank, a second storage tank, a circulating pump, a pipeline system, a detection device for measuring process variables including flow, pressure and temperature, and a data acquisition and control system. An operation parameter control system is provided to control an operation state of valves at different positions of the pipeline system to achieve the switching of the operation mode of the experimental system. The data acquisition and control system is configured to collect the parameters at different detection points. A method for operating the experimental system is also provided.

DIAGNOSIS OF SEPSIS

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set. 1113-. (canceled)114. A method of predicting sepsis in a subject at risk for developing sepsis , the method comprising:obtaining from at least one blood sample taken from a SIRS-positive subject an expression level of IL-6 protein, IL-8 protein, MMP9 nucleic acid and/or protein, and OSM nucleic acid; anddetermining that the subject is likely to develop sepsis based on the expression level of each of IL-6 protein, IL-8 protein, MMP9 nucleic acid and/or protein and OSM nucleic acid being elevated compared to a control expression level of each, wherein said control expression level of each is from SIRS patients that did not develop sepsis.115. The method of claim 114 , wherein the at least one blood sample was taken from said subject at a single point in time.116. The method of claim 114 , wherein the expression level of IL-6 protein claim 114 , IL-8 protein claim 114 , MMP9 nucleic acid and/or protein claim 114 , and OSM nucleic acid is determined from a plurality of blood samples taken from said subject at different points in time.117. The method of claim 116 , wherein at least one of the expression level of IL-6 protein claim ...

NUCLEIC ACID INTEGRATED DETECTION METHOD AND DETECTION REAGENT TUBE

A nucleic acid integrated detection method and detection reagent tube are provided, separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube. 1. A nucleic acid integrated detection method , the method comprising:separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs arranged one above one another and disposing a hydrophobic layer in a liquid or a solid phase at each separation plug;adding a sample into the lysis solution for mixing and lysis;extracting a nucleic acid in the sample using magnetic nanobeads; and then driving, by an external magnet, the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel in an inner wall of the detection reagent tube and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, wherein a biological agent required in the reaction solution is stored in a separation plug above the reaction solution; anddetecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a ...

METHOD FOR DESIGNING REFINER PLATES WITH THREE-STAGE RADIAL CURVED BARS

The present invention discloses a method for designing a refiner plate with three-stage radial curved bars, comprising following steps of: designing a circle arc for 1stage radial curved bars; designing a circle arc for the 2stage radial curved bars; designing a circle arc for 3stage radial curved bars; and designing a center angle for the refiner plate according to the size of the refiner plate and the manufacture requirements, to complete the design of the refiner plate. In the present invention, by the establishment of equations for the circle arcs and angles of inclination of the curved bars, it is ensured that the width of the bars will not change in the radial direction, and both the flexibility in designing a curved refiner plate and the uniformity of crushing are improved. This design method provides a theory basis and also instructions for designing multi-stage radial curved bars. 1. A method for designing a refiner plate with three-stage radial curved bars , comprising following steps of:{'sub': st', 'st', 'st', 'st', 'st, '1) designing a circle arc for 1stage radial curved bars: defining an angle of inclination of the 1stage curved bars, establishing a center circle arc for the 1stage curved bars by the angle of inclination of the 1stage curved bars and a starting position, and establishing an equation of circle arcs for the 1stage curved bars;'}{'sub': nd', 'st', 'nd', 'nd', 'nd', 'st, '2) designing a circle arc for the 2stage radial curved bars: defining an angle of inclination of the 1stage curved bars and a radius of a circle where the 2stage curved bars start, dividing the refiner disc into zones, establishing an equation of circle arcs for the 2stage curved bars, and uniformly distributing the 2stage bars between the adjacent 1stage bars;'}{'sub': rd', 'rd', 'rd', 'rd', 'rd', 'st', 'nd', 'nd, '3) designing a circle arc for 3stage radial curved bars: defining an angle of inclination of the 3stage curved bars and a radius of a circle where the 3stage ...

Method for designing refiner plates with equidistant curved bars

The present invention discloses a method for designing a refiner plate with equidistant curved bars, comprising following steps of: designing a central bar are of center curved bar and defining the bar angle for the equidistant curved bar; designing circle arcs for curved bars on two sides of center curved bar of equidistant curved bar segment; when the whole refining segment is full of circle arcs, trimming lines of outer circle arcs of the refining segment to complete the design of equidistant circle arcs on the two sides; and if required, dividing the bars into zones. In the present invention, by the definition of the bar angle for the curved bars and the parametric design of the equidistant curved bars by using circle are equations, it is ensured that the flexibility in designing an equidistant curved bar refiner plate is improved.

IMMUNO-AMPLIFICATION

A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. 1. A method of detecting an analyte , comprising: (a) an analyte;', '(b) a first proximity member, comprising a first analyte-specific binding entity that is capable of forming a complex with the analyte and that is conjugated to a tether oligonucleotide moiety comprising a first portion and a second portion;', '(c) a second proximity member, comprising a second analyte-specific binding entity that is capable of forming a complex with the analyte and that is conjugated to an oligonucleotide moiety comprising a first portion;', '(d) a splint oligonucleotide, comprising (i) a first portion that is capable of hybridizing to the first portion of the oligonucleotide moiety and (ii) a second portion that is capable of hybridizing to the first portion of the tether oligonucleotide moiety;, '(i) combining (a) a first hybrid comprising the first portion of the oligonucleotide moiety, the first portion of the splint oligonucleotide, and an extendable terminus of either the oligonucleotide moiety or the splint oligonucleotide; and', '(b) a second hybrid comprising the first portion of the tether oligonucleotide and the second portion of the tether oligonucleotide ...

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Methods and compositions for direct chemical lysis

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated. 1. (canceled)2. A method for analyzing a sample stored in a specimen storage composition comprising:combining the sample with a direct chemical lysis composition consisting essentially of a) an assay compatible buffer composition consisting of a buffer component and a metal salt component; and b) an assay compatible surfactant selected from the group consisting of Triton® X-100, polysorbate, and a polyethylene glycol based non-ionic surfactant, wherein the sample is a liquid-based cytology sample;removing at least a portion of the combination of liquid-based cytology sample and direct chemical lysis composition wherein the removed portion is also a combination of the non-fixed liquid-based cytology sample and the direct chemical lysis composition;incubating the removed portion of the of the combination of liquid-based cytology sample and direct chemical lysis composition at a temperature that is at least 80° C. for a time sufficient to lyse at least a portion of the cells in the removed ...

METHOD AND APPARATUS FOR GENERATING SPREADING SEQUENCE CODEBOOKS

A method and apparatus for generating and utilizing spreading sequence codebooks for a symbol-level sequence spreading is disclosed. In one embodiment, a method performed by a wireless communication device, comprising: receiving a first number from a wireless communication node; selecting a first spreading sequence codebook from at least one spreading sequence codebook; selecting a first spreading sequence from the first spreading sequence codebook according to the first number; and spreading data symbols according to the first spreading sequence, wherein the at least one spreading sequence codebook each comprises a plurality of spreading sequences configured based on one entry of a first sequence set after cyclic shifting operation, wherein the first sequence set before cyclic shifting operation is configured based on a second sequence set. 1. A method performed by a wireless communication device , comprising:receiving a first number from a wireless communication node;selecting a first spreading sequence codebook from at least one spreading sequence codebook;selecting a first spreading sequence from the first spreading sequence codebook according to the first number; andspreading data symbols according to the first spreading sequence,wherein the at least one spreading sequence codebook each comprises a plurality of spreading sequences configured based on one entry of a first sequence set after cyclic shifting operation, wherein the first sequence set before cyclic shifting operation is configured based on a second sequence set, wherein the second sequence set comprises at least one of the following, a first entry comprising {1, 2, 4}, a second entry comprising {0, 1, 3, 9}, a third entry comprising {0 2, 6, 7, 8, 10}, a fourth entry comprising {1, 5, 11, 24, 25, 27}, a fifth entry comprising {3, 6, 7, 9, 11, 12, 13, 14}, a sixth entry comprising {0, 1, 9, 23, 44, 47, 49} and a seventh entry comprising {1, 8, 9, 11, 25, 37, 69, 88, 94, 99, 103, 121}.3. The method of ...

RANDOM-ACCESS SENDING AND RECEIVING METHOD AND APPARATUS, TRANSMITTING END AND RECEIVING END

Provided are a random-access sending and receiving method and apparatus, transmitting end, receiving end, and storage medium. The random-access sending method includes: a preamble resource is acquired, and preamble information is generated; a pilot resource is determined according to the preamble resource and a user equipment identifier, and pilot information is generated; data information is acquired, and the data information is mapped to a time-frequency resource, the data information including user equipment identifier information; and a radio frame is formed from the preamble information, the pilot information and the data information, and the radio frame is sent. 1. A random-access sending method , comprising:acquiring a preamble resource, and generating preamble information;determining a pilot resource according to the preamble resource and a user equipment identifier, and generating pilot information;acquiring data information, and mapping the data information to a time-frequency resource, wherein the data information comprises user equipment identifier information; andforming a radio frame from the preamble information, the pilot information and the data information, and sending the radio frame.2. The method according to claim 1 , whereinthe preamble resource is one of a plurality of preamble resource groups in a preamble resource pool;the pilot resource is one of a plurality of non-overlapping pilot resource groups in a pilot resource pool; 'calculating a start index of the pilot resource according to the preamble resource, determining an offset of the pilot resource according to the user equipment identifier, and determining the pilot resource according to the start index and the offset.', 'wherein determining the pilot resource according to the preamble resource and the user equipment identifier comprises4. The method according to any one of claim 1 , wherein a mapping relationship between a time-frequency resource position of the user equipment ...

Methods for detecting nucleic acid sequence variations

The invention employs an unlabeled signal primer comprising a 5′ adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3′ end of which hybridizes to the complement of the 5′ adapter sequence of the signal primer to produce a 5′ overhang. Polymerase is used to fill in the overhang and synthesize the complement of the 5′ overhang of the reporter probe. Synthesis of the reporter probe complement is detected, either directly or indirectly, as an indication of the presence of the target.

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Immuno-amplification

A highly sensitive, high-throughput immuno-amplification assay is provided for clinically relevant samples, such as blood. The assay comprises the use of two proximity members comprising an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members sufficiently close to form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. In one embodiment, target-independent amplicon formation is prevented by using hybridization blocker oligonucleotides that bind oligonucleotide moieties that are not hybridized to each other. Background is further reduced by providing a solid phase capture oligonucleotide that prevents amplicon formation until the captured complex is released.

Methods and compositions for direct chemical lysis

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

Immuno-amplification

A highly sensitive, high-throughput immuno-amplification assay is provided for clinically relevant samples, such as blood. The assay comprises the use of two proximity members comprising an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members sufficiently close to form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. In one embodiment, target-independent amplicon formation is prevented by using hybridization blocker oligonucleotides that bind oligonucleotide moieties that are not hybridized to each other. Background is further reduced by providing a solid phase capture oligonucleotide that prevents amplicon formation until the captured complex is released.

Immuno-amplification

Aminopyrazole derivative

Methods and compositions for direct chemical lysis

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

Methods and compositions for direct chemical lysis

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

Diagnosis of sepsis

Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Binocular visual function examination instrument

The present invention discloses a binocular visual function examination instrument, relating to the field, of medical examination device. The instrument comprises an examination instrument body and a head positioning device fixedly arranged on 5 a front side of the examination instrument body, wherein the head positioning device comprises a lower jaw support with an adjustable height and an upper forehead support with an adjustable back—forth position; by setting the lower jaw support adjustable up and, down and, an upper forehead, support adjustable back and 10 forth, a subject can perform adjustment conformably according to his height and facial size, so that the head can be fixed in a comfortable posture, improving the comfort of the subject and improving the test effect; by rotating a forehead support frame, the subject can adjust the pitch angle of his head after the back— 15 forth position of the head is fixed. (+ Fig.)

一种适用中大型犬的犬笼

本实用新型涉及犬笼技术领域，尤其涉及一种适用中大型犬的犬笼；包括地板(1)；所述地板(1)上部设置有犬用铁笼(101)；所述犬用铁笼(101)一侧设置有输送水管(102)；所述犬用铁笼(101)前端中部靠下位置设置有铁笼门(103)；所述铁笼门(103)与犬用铁笼(101)一侧采用折页连接；所述铁笼门(103)与犬用铁笼(101)另一侧采用弹簧锁连接；所述犬用铁笼(101)外侧设置有多个水管支架(2)。

Image processing method, image processing system, and non-transitory computer readable medium

An image processing method according to an embodiment includes a specifying step, an inference step, and an integration step. In the specifying step, a first portion including a region corresponding to an anatomical site of a target and a second portion including a region different from the anatomical site are specified in the image. In the inference step, by using a deep learning model, segmentation of the region corresponding to the anatomical site is performed on the first portion and segmentation of the region different from the anatomical site is performed on the second portion, or classification and detection of an image including the region corresponding to the anatomical site is performed on the first portion and classification and detection of an image including the region different from the anatomical site is performed on the second portion. In the integration step, results of the respective processes are integrated for output.

Device for live erection of pole

The present disclosure provides a device for live erection of a pole. A movable arm is fixed onto a vehicle The present disclosure can assist to complete erection of an electric pole under the condition that a high-tension wire is not powered off, avoid interference with the high-tension wire and reduce the potential safety hazards of operators.

Self-locking anti-drop manipulator

The invention discloses a self-locking anti-drop manipulator, which comprises a hand body and mechanical fingers arranged on the hand body, wherein the back of the mechanical fingers is provided with an anti-dropping mechanism for preventing an object to be grabbed from being thrown out when the manipulator moves at a high speed; the anti-drop mechanism comprises an anti-drop retaining arm rotatably installed on the back of a mechanical finger and a retaining arm control device for driving the anti-drop retaining arm to rotate and forming a barrier on the bottom of an object to be grabbed; while ensuring the high-speed operation of materials, it can stably grab materials, and avoid damage to materials caused by falling, thus improving the yield of production process.

Pesticide spraying vehicle for crops

The invention discloses a pesticide spraying vehicle for crops, which comprises a vehicle frame, a pesticide storage barrel fixed on the vehicle frame, and lateral side arms with internal flow cavities, wherein the flow cavities are communicated with the pesticide storage barrel, two lateral side arms are arranged and respectively installed on the lateral sides of the vehicle frame, and the bottom of the lateral side arms are sequentially provided with a plurality of pesticide spray nozzles at intervals along the length direction; the lateral side arms are in a front-back folding structure and are folded to realize unilateral lateral spraying width adjustment; it can ensure efficient work and improve the spraying accuracy.

画像処理方法、画像処理システム及び画像処理プログラム

【課題】深層学習モデル推論時の精度と速度のバランスを実現し、より望ましい推論結果を得ること。【解決手段】実施形態に係る画像処理方法は、特定ステップと、推論ステップと、統合ステップとを含む。特定ステップは、画像における、対象の解剖学的部位に対応する領域を含む第一部分と、前記解剖学的部位と異なる領域を含む第二部分とを特定する。推論ステップは、深層学習モデルを利用して、前記第一部分に対して前記解剖学的部位に対応する領域を特定するセグメンテーション処理を行い、前記第二部分に対して前記解剖学的部位と異なる領域を特定するセグメンテーション処理を行う、又は、前記第一部分に対して前記解剖学的部位に対応する領域を含む画像を分類検出する分類処理を行い、前記第二部分に対して前記解剖学的部位と異なる領域を含む画像を分類検出する分類処理を行う。統合ステップは、各処理の結果を統合して出力する。【選択図】図３

Binocular visual function examination instrument

The present invention discloses a binocular visual function examination instrument, relating to the field, of medical examination device. The instrument comprises an examination instrument body and a head positioning device fixedly arranged on a front side of the examination instrument body, wherein the head positioning device comprises a lower jaw support with an adjustable height and an upper forehead support with an adjustable back—forth position; by setting the lower jaw support adjustable up and, down and, an upper forehead, support adjustable back and forth, a subject can perform adjustment conformably according to his height and facial size, so that the head can be fixed in a comfortable posture, improving the comfort of the subject and improving the test effect; by rotating a forehead support frame, the subject can adjust the pitch angle of his head after the back— forth position of the head is fixed.

Device for live erection of pole

The present disclosure provides a device for live erection of a pole. A movable arm is fixed onto a vehicle The present disclosure can assist to complete erection of an electric pole under the condition that a high-tension wire is not powered off, avoid interference with the high-tension wire and reduce the potential safety hazards of operators.

画像処理装置及び画像処理方法

【課題】画質を向上させること。【解決手段】実施形態に係る画像処理装置は、残差初期化部と、更新データ生成部と、残差更新部と、再構成部とを備える。残差初期化部は、アンダーサンプリングされたｋ空間データとｋ空間データ真値との差を示す残差を初期化する。更新データ生成部は、前記残差及び前記ｋ空間データに基づいて画像処理を行い、前記残差を更新するための残差更新用データを生成する第１のニューラルネットワークを有する。残差更新部は、前記残差更新用データ及びアンダーサンプリングに利用したマスクに基づいて前記残差を更新する。再構成部は、前記ｋ空間データと更新された前記残差に基づいて画像データを再構成する。【選択図】図１

医用画像処理装置及び医用画像処理方法

【課題】セグメンテーションに関するユーザの負担を軽減することである。【解決手段】実施形態に係る医用画像処理装置は、セグメンテーション部と、選択部と、表示制御部とを備える。セグメンテーション部は、複数の医用画像を含む医用画像セットに対してセグメンテーションを行って、当該セグメンテーションの第１結果を出力する。選択部は、過去に実行された前記セグメンテーションの第２結果と、当該第２結果が修正された第３結果との差異に基づいて、前記複数の医用画像のうち、前記第１結果の修正対象として好適な対象画像を選択する。表示制御部は、前記対象画像を表示する。【選択図】図４

液压式搅拌双向莲蓉炒锅

本实用新型涉及搅拌炒锅附属装置的技术领域，特别是涉及一种液压式搅拌双向莲蓉炒锅，在清洗炒锅的时候，其通过将两组搅拌组件在炒锅内部灵活拆卸使锅体和两组搅拌组件分开清洗，因此增强了液压式搅拌双向莲蓉炒锅的清洗便捷性，同时降低了两组搅拌组件在炒锅内的清洗难度；包括机架、锅体、电机、搅拌轴和操控机构，机架的顶端左侧和右侧分别转动设置有两组抬动杆，机架的右部区域内部设置有工作腔；还包括两组带动杆、定位环、两组定位板、两组限位杆、两组限位弹簧、两组推动板、两组卡杆和两组搅拌组件，定位环的左部区域和右部区域的内部分别设置有两组定位腔，两组限位杆的内部分别设置有两组限位腔。

Methods and compositions for direct chemical lysis

A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

Model training device and model training method

A model training device according to an embodiment of the present disclosure includes processing circuitry. The processing circuitry is configured to obtain an initial learning model by learning a data set including medical images as learning data. The processing circuitry is configured to evaluate the initial learning model by using a global metric, so as to obtain error data sets each having an outlier from among a plurality of data sets used in the evaluation. The processing circuitry is configured to obtain a plurality of error data set groups by grouping the plurality of error data sets while using a local metric. The processing circuitry is configured to specify model training information with respect to each of the error data set groups.

モデル訓練装置およびモデル訓練方法

【課題】モデルの精度を向上させること。 【解決手段】本実施形態に係るモデル訓練装置は、訓練部と、評価部と、グループ化部と、モデル訓練情報特定部と、を備える。前記訓練部は、医用画像を含むデータセットを学習データとして学習することによって、初期学習モデルを得る。前記評価部は、グローバルメトリクスを利用して、前記初期学習モデルを評価することによって、前記評価に用いられる複数のデータセットのうちの、外れ値となる異常データセットを取得する。前記グループ化部は、局部メトリクスを利用して、前記評価部により取得された前記複数の異常データセットをグループ化することで複数の異常データセットグループを得る。前記モデル訓練情報特定部は、前記グループ化部で得られた前記異常データセットグループ毎に、モデル訓練情報を特定する。 【選択図】図１Ｂ

Safety device for preventing electric shock of plug

U I T T R E K S E L The present invention discloses a safety device for preventing electric shock of a plug, which comprises a base frame detachably fixed to a socket panel and a frame top cover detachably locked to the base frame, wherein the frame top cover is provided with a 5 wire outlet hole for a plug wire to pass through; the frame top cover is locked and fixed to the base frame and at the same time is used to cover and fix the plug inserted on the socket panel, so as to prevent the plug from being extracted by a child and meet an electricity demand, and at the same time, avoid a risk of child 10 electric shock and ensure an electricity safety, and have a simple structure and a low cost. (+ Fig.)

Safety device for preventing electric shock of plug

The present invention discloses a safety device for preventing electric shock of a plug, which comprises a base frame detachably fixed to a socket panel and a frame top cover detachably locked to the base frame, wherein the frame top cover is provided with a wire outlet hole for a plug wire to pass through; the frame top cover is locked and fixed to the base frame and at the same time is used to cover and fix the plug inserted on the socket panel, so as to prevent the plug from being extracted by a child and meet an electricity demand, and at the same time, avoid a risk of child electric shock and ensure an electricity safety, and have a simple structure and a low cost.

Sound-free floor slab

The present utility model discloses a sound-free floor slab. Top lacing bars are stretchable and fixed with tie bars by double-sided ball placers and compression fittings suspended at one side of the tie bars, which are specifically used for solid and lightweight balls, such that the solid and lightweight balls will not be flushed away from pre-determined locations upon grouting the floor slab.

Immuno-amplification

A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.