07-11-2019 дата публикации
Номер: US20190336499A1
Принадлежит:
The present disclosure relates to solid state forms of Selinexor, processes for preparation thereof and pharmaceutical compositions thereof. 1. A crystalline form of Selinexor designated as Form T8 , characterized by data selected from one or more of the following:a. an X-ray powder diffraction pattern having peaks at 6.0, 13.4, 17.6, 19.6, and 24.9 degrees 2-theta±0.2 degrees 2-theta;{'figref': {'@idref': 'DRAWINGS', 'FIG. 8'}, 'b. an XRPD pattern as depicted in ;'}{'sup': '13', 'c. a solid state C-NMR spectrum having characteristic peaks at 107.5, 126.0, 132.2, 141.5, 151.7 and 157.9 ppm±0.2 ppm;'}{'sup': '13', 'd. a solid state C-NMR spectrum having the following chemical shift absolute differences from a reference peak at 154.1 ppm±2 ppm of 46.6, 28.1, 21.9, 12.6 , 2.4 and 3.8 ppm±0.1 ppm;'}{'sup': '13', 'figref': {'@idref': 'DRAWINGS', 'FIG. 18 or 19 or 20'}, 'e. a solid state C-NMR spectrum as depicted in ; and'}f. a combination of any two or more of the above.2. The crystalline Form T8 of Selinexor according to claim 1 , characterized by an XRPD pattern having peaks at 6.0 claim 1 , 13.4 claim 1 , 17.6 claim 1 , 19.6 claim 1 , and 24.9 degrees 2-theta±0.2 degrees 2-theta claim 1 , and also having one claim 1 , two claim 1 , three claim 1 , four or five additional peaks selected from 15.3 claim 1 , 20.8 claim 1 , 23.3 claim 1 , 26.4 and 29.6 degrees two theta±0.2 degrees two theta.3. A crystalline form of Selinexor designated as Form T1 claim 1 , characterized by data selected from one or more of the following:a. an XRPD pattern having peaks 10.2, 16.9, 21.1, 21.5, 22.7, and 26.7 degrees 2-theta±0.2 degrees 2-theta;{'figref': {'@idref': 'DRAWINGS', 'FIG. 1'}, 'b. an XRPD pattern as depicted in ; and'}c. a combination of (a) and (b).4. The crystalline Form T1 of Selinexor according to claim 3 , characterized by an XRPD pattern having peaks at 10.2 claim 3 , 16.9 claim 3 , 21.1 claim 3 , 21.5 claim 3 , 22.7 claim 3 , and 26.7 degrees 2-theta±0.2 degrees 2-theta ...
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