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Применить Всего найдено 4. Отображено 4.
02-08-2016 дата публикации

Insulin producing cells derived from pluripotent stem cells

Номер: US0009404087B2
Автор: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Kfir Molakandov, Rosalia Kaufman, REVEL MICHEL, CHEBATH JUDITH, SLUTSKY GUY, LEVY ALON, IZRAEL MICHAL, HASSON ARIK, MOLAKANDOV KFIR, KAUFMAN ROSALIA, Revel Michel, Chebath Judith, Slutsky Guy, Levy Alon, Izrael Michal, Hasson Arik, Molakandov Kfir, Kaufman Rosalia
Принадлежит: Kadimastem Ltd., REVEL MICHEL, CHEBATH JUDITH, SLUTSKY GUY, LEVY ALON, IZRAEL MICHAL, HASSON ARIK, MOLAKANDOV KFIR, KAUFMAN ROSALIA, KADIMASTEM LTD, Revel Michel, Chebath Judith, Slutsky Guy, Levy Alon, Izrael Michal, Hasson Arik, Molakandov Kfir, Kaufman Rosalia

A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.

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Номер записи: 1
17-10-2013 дата публикации

Insulin producing cells derived from pluripotent stem cells

Номер: US20130273013A1
Автор: Alon Levy, Arik Hasson, Guy Slutsky, Judith Chebath, Michal Izrael, Michel Revel, MOLAKANDOV Kfir, Rosalia Kaufman
Принадлежит: KADIMASTEM Ltd

A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.

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Номер записи: 2
13-10-2020 дата публикации

Insulin producing cells derived from pluripotent stem cells

Номер: CA2816495C
Автор: Alon Levy, Arik Hasson, Guy Slutsky, Judith Chebath, Kfir Molakandov, Michal Izrael, Michel Revel, Rosalia Kaufman
Принадлежит: KADIMASTEM Ltd

A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.

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Номер записи: 3
21-06-2012 дата публикации

Insulin producing cells derived from pluripotent stem cells

Номер: CA2816495A1
Автор: Alon Levy, Arik Hasson, Guy Slutsky, Judith Chebath, Kfir Molakandov, Michal Izrael, Michel Revel, Rosalia Kaufman
Принадлежит: KADIMASTEM Ltd

A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.

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Номер записи: 4