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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 26. Отображено 26.
21-11-2017 дата публикации

Reconfigurable sensor monitoring system

Номер: US0009825641B1

A reconfigurable sensor monitoring system includes software tunable filters, each of which is programmable to condition one type of analog signal. A processor coupled to the software tunable filters receives each type of analog signal so-conditioned.

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25-04-2017 дата публикации

Reconfigurable drive current system

Номер: US0009632491B1

A reconfigurable drive current system includes drive stages, each of which includes a high-side transistor and a low-side transistor in a totem pole configuration. A current monitor is coupled to an output of each drive stage. Input channels are provided to receive input signals. A processor is coupled to the input channels and to each current monitor for generating at least one drive signal using at least one of the input signals and current measured by at least one of the current monitors. A pulse width modulation generator is coupled to the processor and each drive stage for varying the drive signals as a function of time prior to being supplied to at least one of the drive stages.

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08-05-2013 дата публикации

New process

Номер: CN103097345A
Принадлежит:

Disclosed is a process for the preparation of a compound of formula (I) which are useful as intermediates in the preparation of pharmaceutically active compounds.

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28-03-2013 дата публикации

NOVEL PROCESS

Номер: US20130079541A1
Принадлежит: Hoffmann-La Roche Inc.

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound. 2. A process according to claim 1 , wherein said reaction is carried out with at least 0.10M of said reducing agent.3. A process according to claim 1 , wherein the said reducing agent is selected from the group consisting of: phosphines claim 1 , phosphinites claim 1 , phosphonites and phosphites.4. A process according to claim 1 , which further comprises the oxidation of excess reducing agent with an oxidizing agent.5. A process according to claim 4 , wherein the oxidizing agent is peroxymonosulfate or hydrogen peroxide.6. A process according to claim 1 , wherein the said reducing agent is a phosphine.7. A process according to claim 1 , wherein the said reducing agent is triphenyl phosphine.8. A process according to which further comprises the removal of the phosphine oxide claim 3 , phosphinate claim 3 , phosphonate or phosphate produced in said reaction using water/alcohol extraction from an organic solvent.9. A process according to claim 8 , wherein said reducing agent is a phosphine and the phosphine oxide produced in said reaction is removed using water/alcohol extraction from an organic solvent.10. A process according to which further comprises crystallizing the compound of formula (I) using a solvent-antisolvent process with water as the antisolvent and the solvent being a water-miscible solvent.1110. A process according to wherein the water miscible solvent is acetone claim 1 , ethanol claim 1 , isopropanol claim 1 , propanol or mixtures thereof.12. A process according to which further comprises crystallizing the compound of formula (I) by cooling a solution of said compound of formula (I) in a non-polar solvent.13. A process according to claim 1 , which further comprises the following steps:a) forming a solution of said compound of formula (I) in acetone, ethanol, ...

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01-08-2013 дата публикации

NEW PROCESS

Номер: US20130197257A1
Принадлежит: Hoffmann-La Roche Inc.

A process for the preparation of a compound of formula (I): 2. A process according to claim 1 , wherein the coupling reaction is carried out in the presence of a secondary amine.3. A process according to claim 2 , wherein Ris pent-3-yl.9. A process according to claim 1 , wherein the coupling reaction is followed by a mineral acid quenching with hydrofluoric acid claim 1 , hydrochloric acid claim 1 , boric acid claim 1 , acetic acid claim 1 , formic acid claim 1 , nitric acid claim 1 , phosphoric acid or sulfuric acid.10. A process according to claim 1 , wherein the coupling reaction is followed by a hydrochloric acid quenching.11. A process according to claim 1 , wherein a nonprotic solvent is present.12. A process according to claim 11 , wherein the nonprotic solvent is tetrahydrofuran.13. A process according to claim 11 , wherein the alkylating agent is 1-halo-CHRor a sulfonate ester of RCH—OH wherein Ris defined in .14. A process according to claim 1 , wherein the alkylating agent is 1-halo-2-ethylbutane.15. A process according to claim 1 , wherein the alkylating agent is 2-ethyl-1-butanol.16. A process according to claim 1 , wherein the alkylating agent is 1-bromo-2-ethylbutane.17. A process according to claim 1 , wherein the Grignard reagent is a (C-C)alkyl-magnesium-halide claim 1 , phenyl-magnesium-halide claim 1 , heteroaryl-magnesium-halide or a (C-C)cycloakyl-magnesium-halide.18. A process according to claim 1 , wherein the Grignard reagent is methylmagnesiumchloride.19. A process according to claim 2 , wherein the secondary amine is diethylamine or diisopropylamine.20. A process according to claim 2 , wherein the secondary amine is diethylamine.21. A process according to claim 2 , wherein the secondary amine is in a catalytic amount.22. A process according to claim 2 , wherein 0.01 to 0.5 equivalents of the secondary amine is used.23. A process according to claim 2 , wherein the process is continuous.24. A process according to claim 8 , wherein the ...

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19-12-2013 дата публикации

NOVEL PROCESS

Номер: US20130338391A1
Принадлежит: Hoffmann-La Roche Inc.

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound. 2. A process according to claim 1 , wherein said reaction is carried out with at least 0.10 M of said reducing agent.3. A process according to claim 1 , wherein the said reducing agent is selected from the group consisting of: phosphines claim 1 , phosphinites claim 1 , phosphonites and phosphites.4. A process according to claim 1 , which further comprises the oxidation of excess reducing agent with an oxidizing agent.5. A process according to claim 4 , wherein the oxidizing agent is peroxymonosulfate or hydrogen peroxide.6. A process according to claim 1 , wherein the said reducing agent is a phosphine.7. A process according to claim 1 , wherein the said reducing agent is triphenyl phosphine.8. A process according to which further comprises the removal of the phosphine oxide claim 3 , phosphinate claim 3 , phosphonate or phosphate produced in said reaction using water/alcohol extraction from an organic solvent.9. A process according to claim 8 , wherein said reducing agent is a phosphine and the phosphine oxide produced in said reaction is removed using water/alcohol extraction from an organic solvent.10. A process according to which further comprises crystallizing the compound of formula (I) using a solvent-antisolvent process with water as the antisolvent and the solvent being a water-miscible solvent.11. A process according to 10 wherein the water miscible solvent is acetone claim 1 , ethanol claim 1 , isopropanol claim 1 , propanol or mixtures thereof.12. A process according to which further comprises crystallizing the compound of formula (I) by cooling a solution of said compound of formula (I) in a non-polar solvent.13. A process according to claim 1 , which further comprises the following steps:a) forming a solution of said compound of formula (I) in acetone, ethanol, ...

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14-07-2016 дата публикации

NEW PROCESS

Номер: US20160200672A1
Принадлежит:

A process for the preparation of a compound of formula (I): 2. A process according to claim 1 , wherein the coupling reaction is carried out in the presence of a secondary amine.3. A process according to claim 2 , wherein Ris pent-3-yl.9. A process according to claim 1 , wherein the coupling reaction is followed by a mineral acid quenching with hydrofluoric acid claim 1 , hydrochloric acid claim 1 , boric acid claim 1 , acetic acid claim 1 , formic acid claim 1 , nitric acid claim 1 , phosphoric acid or sulfuric acid.10. A process according to claim 1 , wherein the coupling reaction is followed by a hydrochloric acid quenching.11. A process according to claim 1 , wherein a nonprotic solvent is present.12. A process according to claim 11 , wherein the nonprotic solvent is tetrahydrofuran.13. A process according to claim 11 , wherein the alkylating agent is 1-halo-CHRor a sulfonate ester of RCH—OH wherein Ris defined in .14. A process according to claim 1 , wherein the alkylating agent is 1-halo-2-ethylbutane.15. A process according to claim 1 , wherein the alkylating agent is 2-ethyl-1-butanol.16. A process according to claim 1 , wherein the alkylating agent is 1-bromo-2-ethylbutane.17. A process according to claim 1 , wherein the Grignard reagent is a (C-C)alkyl-magnesium-halide claim 1 , phenyl-magnesium-halide claim 1 , heteroaryl-magnesium-halide or a (C-C)cycloakyl-magnesium-halide.18. A process according to claim 1 , wherein the Grignard reagent is methylmagnesiumchloride.19. A process according to claim 2 , wherein the secondary amine is diethylamine or diisopropylamine.20. A process according to claim 2 , wherein the secondary amine is diethylamine.21. A process according to claim 2 , wherein the secondary amine is in a catalytic amount.22. A process according to claim 2 , wherein 0.01 to 0.5 equivalents of the secondary amine is used.23. A process according to claim 2 , wherein the process is continuous.24. A process according to claim 8 , wherein the ...

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13-11-2014 дата публикации

Process

Номер: US20140336403A1
Принадлежит: Hoffmann La Roche Inc

A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.

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17-12-2015 дата публикации

New process

Номер: US20150361034A1
Принадлежит: Hoffmann La Roche Inc

A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.

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08-06-2000 дата публикации

Position sensor with integrated signal-conditioning electronics on a printed wiring board

Номер: WO2000033020A1

A position sensor, such as a rotary position sensor, includes the signal-contitioning electronics in the housing. The signal-conditioning electronics are disposed on a printed wiring board, which is assembled with another printed wiring board (25) including the sensor windings to provide a sub-assembly (39). A mu-metal shield (31) is interposed between the printed wiring boards to prevent magnetic interference. The sub-assembly (39) is disposed in the sensor housing adjacent to an inductor board (15) which turns on a shaft. The inductor board (15) emanates an internally or externally generated excitation signal that induces a signal in the sensor windings. The induced signal represents the rotary position of the inductor board (15) relative to the sensor winding board.

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03-02-2015 дата публикации

A process for the preparation of s-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]-2-methylthiopionate

Номер: CA2764969C
Принадлежит: F Hoffmann La Roche AG

The present invention relates to a process for the preparation of S-[2-[1-(2 ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate (see formula I) which is a useful pharmaceutical active compound. The process comprises reacting a compound of formula (II) (see formula II) with isobutyric anhydride and a reducing agent.

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20-01-1994 дата публикации

Direct esterification of mycophenolic acid

Номер: WO1994001427A1
Принадлежит: Syntex (U.S.A.) Inc.

Mycophenolate mofetil is made non-catalytically by refluxing mycophenolic acid with 2-morpholinoethanol in an inert organic solvent capable of azeotropic removal of water.

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08-10-2009 дата публикации

New process for the preparation of cyclohexanecarboxylic acid derivatives

Номер: CA2717955A1
Принадлежит: F Hoffmann La Roche AG

A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

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26-04-1995 дата публикации

Direct esterification of mycophenolic acid.

Номер: EP0649422A1
Принадлежит: Syntex USA LLC

Mycophenolate mofetil is made non-catalytically by refluxing mycophenolic acid with 2-morpholinoethanol in an inert organic solvent capable of azeotropic removal of water.

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22-03-2012 дата публикации

New process

Номер: CA2809215A1
Принадлежит: F Hoffmann La Roche AG

A process for the preparation of a compound of formula (I) which are useful as intermediates in the preparation of pharmaceutically active compounds.

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09-05-2012 дата публикации

Preparation and crystallisation of s-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]-2-methylthiopropionate

Номер: EP2448918A2
Принадлежит: F Hoffmann La Roche AG

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.

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29-03-2016 дата публикации

new process.

Номер: BRPI1011803A2
Принадлежит: Hoffaman La Roche F

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01-05-1997 дата публикации

DIRECT ESTERIFICATION OF MYCOPHENOLIC ACID.

Номер: ES2098763T3
Принадлежит: Syntex USA LLC

MOFETIL MICOFENOLATO SE PRODUCE NO CATALITICAMENTE REFLUYENDO ACIDO MICOFENOLICO CON 2 NTE ORGANICO INERTE CAPAZ DE EXTRACCION AZEOTROPICA DEL AGUA.

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21-06-2002 дата публикации

Direct esterification of mycophenolic acid

Номер: CY2131B1
Принадлежит: Syntex Inc

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27-03-2012 дата публикации

Preparation for a cyclohexanecarboxylic acid derivative and intermediates

Номер: US8143442B2
Принадлежит: Hoffmann La Roche Inc

A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

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06-01-2011 дата публикации

A process for the preparation of s-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]-2-methylthiopionate

Номер: CA2764969A1
Принадлежит: F Hoffmann La Roche AG

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.

Подробнее
30-01-2014 дата публикации

Preparation and crystallisation of S-[2-[1-(2-ethylbutyl) cyclohexylcarbonylamino]-phenyl]-2-methylthiopropionate

Номер: AU2010268173B2
Принадлежит: F Hoffmann La Roche AG

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.

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08-04-2013 дата публикации

New process.

Номер: MX2013002656A
Принадлежит: Hoffmann La Roche

La presente invención se refiere a un proceso para la preparación de un compuesto de la fórmula (I) que es útil como un compuesto intermedio en la preparación de los compuestos activos farmacéuticamente.

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15-04-1997 дата публикации

Direkt veresterung von mycophenolsäure

Номер: ATE150460T1
Принадлежит: Syntex Inc

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