Trainer

A trainer is disclosed which is useful for developing skill in sports of coordination including for instance beer-pong.

Charge air cooler cover and turbocharger bracket

A charge air cooler cover includes a nozzle configured for connection to an outlet of a compressor for receiving charge air, a tray configured for connection to an inlet of a charge air cooler, and a plenum leading from the nozzle to a plurality of passages defined by a plurality of ribs. The plurality of passages connects the plenum to the tray. The ribs and the tray are arranged to achieve substantially uniform charge air velocity across the inlet of the charge air cooler, in at least one mode of operation.

Recording Identity Data to Enable on Demand Services in a Communications System

Recording identity data enables telecomm system to provide on-demand services such as Record-ON (RCD), index, bookmark, transcribe, translate and supplement the recording. Party identity uses sender metadata in telecomm data packets. At log-in the station assigns on-demand command (CMD) control tokens and control transfer tokens to each party based on the party's profile. One party has RCD-CMD enabled and, if both parties have a RCD-CMD Transfer Token, parties can transfer RCD-CMD to all. In the absence of RCD-CMD or Transfer, a party cannot activate On-Demand services nor accept control CMD tokens. A call table-database links sender metadata and CMD permissions. 1. A method for recording identity data and enabling on demand services in a communications system wherein said communications system includes a plurality of telecommunications enabled devices , each with a speaker and a microphone for a telecommunications session , said plurality of telecommunications enabled devices communitively coupled via a telecommunications network to a communications station having an on demand recording and voice record storage function and wherein a telecommunications session between two enabled devices and said communications station includes transmission of data packets therebetween which include metadata identifying the sending enabled device and which include on demand control command data and transfer control token command data , the method comprising:at the communications station, assigning an on demand control token to a first enabled device engaged in said telecommunications session;monitoring all data packets;upon recognition of an on demand command request from said sending enabled device which matches said on demand token at the communications station, activating said on demand recording and voice record storage function; and,upon recognition of said transfer control token command data from said first enabled device at the communications station, reassigning said on ...

Key Responsive Record, Navigation and Marking Controls for Communications System

The key responsive record, navigate and marking method operates with a communications station networked with telecommunications enabled devices (cell phones with speakers and microphones). Controls are * and # symbol keys (mechanical or virtual). The station includes an IVR and record data stores. The # key controls RECORD ON/OFF and the * control is end-of-comm-session (EOS). The station activates functions based control key detection. Toggle ON/OFF/ON operations are activated. The EOS stops recording and activate post-recording sessional routines. Other keystroke functions are user-assigned or system defaults for numeric keys 1-2-3-4-5-6-7-8-9-0. Navigation controls are thus activated. 1. A key responsive record , navigation and marking method for controlling a communications system which includes a plurality of telecommunications enabled devices , each with a plurality of actuatable control key elements thereon which include a key bearing a * symbol and a key bearing a # symbol and each with a speaker and a microphone for a telecommunications session , said plurality of telecommunications enabled devices communitively coupled via a telecommunications network to a communications recording station , said communications station having a data recording module and an interactive voice response module for effecting a delivery of audible instructions to a user operating an activated telecommunications enabled device , the key responsive record , navigation and marking control method comprising:receiving a * control signal at said communications station resulting from activation of said * control key on said activated telecommunications enabled device; and,activating an end of telecommunications event routine which includes the cessation of a recording session by said data recording module.2. A key responsive record claim 1 , navigation and marking method for controlling a communications system as claimed in wherein the end of telecommunications event routine includes ...

VACUUM SUCTION TISSUE STABILIZING DEVICE

A system is provided for the control of soft tissues, the system having a negative pressure supply; a negative pressure applicator, coupled to the negative pressure supply and configured to apply a negative pressure to the soft tissue, atraumatically and releasably securing the soft tissue to the negative pressure applicator; and the rigid negative pressure supply being configured to be disposed in an access port without inhibiting the insertion and manipulation of an surgical instrument. 1. A system for the control of soft tissues , said system comprising:a negative pressure supply;a negative pressure applicator, coupled to said negative pressure supply and configured to apply a negative pressure to said soft tissue, atraumatically and releasably securing said soft tissue to said negative pressure applicator; andsaid negative pressure supply being configured to be disposed in an access port without inhibiting the insertion and manipulation of a surgical instrument.2. The system of wherein said negative pressure supply comprises a section of biocompatible surgical tubing.3. The system of wherein said negative pressure applicator comprises an end piece having a negative pressure disseminating cavitation disposed on a side proximal to said soft tissue.4. The system of wherein said cavitation is a groove.5. The system of wherein at least a portion of said rigid negative pressure supply is a helical portion and the inner diameter of said helical portion is configured to receive said surgical instrument.6. The system of wherein said helical portion allows said endoscopic instrument rotational movement in not less than about approximately 300° around the major axis of said surgical instrument.7. The system of further comprising a tissue interface disposed on a side of said negative pressure applicator proximal to said tissue.8. The system of wherein said issue interfaces is a compliant material.9. The system of wherein said negative pressure applicator is an annular ...

NAVIGATION SYSTEM INITIALIZATION WITH INERTIAL DATA COMPENSATION

An example embodiment includes a method for initializing a navigation system. The method includes receiving inertial measurement data from an inertial measurement unit over time and storing the inertial measurement data in a buffer with an indication of a time of validity for the inertial measurement data. The method also includes receiving navigation data from an aiding source, the navigation data having a time of validity, and initializing a navigation solution with the navigation data. The method also includes summing inertial measurement data from the buffer to produce an inertial motion estimate for a time increment after the time of validity of the navigation data, applying at least one of coning or sculling compensation to the inertial motion estimate to produce a compensated inertial motion estimate, and propagating the navigation solution forward based on the compensated inertial motion estimate. 1. A method for initializing a navigation system , the method comprising:receiving inertial measurement data from an inertial measurement unit over time;storing the inertial measurement data in a buffer with an indication of a time of validity for the inertial measurement data;receiving navigation data from an aiding source, the navigation data having a time of validity;initializing a navigation solution with the navigation data;summing inertial measurement data from the buffer to produce an inertial motion estimate for a time increment after the time of validity of the navigation data;applying at least one of coning or sculling compensation to the inertial motion estimate to produce a compensated inertial motion estimate; andpropagating the navigation solution forward based on the compensated inertial motion estimate.2. The method of claim 1 , wherein the aiding source includes one of a master navigation system claim 1 , a satellite navigation system receiver claim 1 , a barometric altimeter claim 1 , a magnetometer claim 1 , and input data from a user.3. The ...

SYSTEMS AND METHODS TO INCORPORATE MASTER NAVIGATION SYSTEM RESETS DURING TRANSFER ALIGNMENT

Systems and methods to incorporate master navigation system resets during transfer alignment are provided. In one embodiment, a system comprises: a set of local inertial sensors; a local navigation processor coupled to local inertial sensors, the local navigation processor receiving inertial navigation data from local inertial sensors and converting the data into a navigation solution; a local Kalman filter (LKF) coupled to the local navigation processor and a master Kalman filter (MKF), the LKF receiving the navigation solution. The LKF receives from the MKF a Precision Transfer Alignment Message (PTAM) that includes at least one navigation aid measurement. The LKF inputs the navigation aid measurement into a measurement formation algorithm and calculates a measurement residual. The LKF receives from the MKF a Reset Transfer Alignment Message (RTAM) that includes a bias correction. The LKF inputs the bias correction into a state propagation algorithm to add to a navigation state. 1. A navigation system for performing a transfer alignment , the navigation system comprising:a set of local inertial sensors;a local strap-down navigation processor coupled to the set of local inertial sensors, the local strap-down navigation processor receiving inertial navigation data from the set of local inertial sensors and converting the inertial navigation data into a navigation solution;a local Kalman filter coupled to the local strap-down navigation processor, the local Kalman filter receiving the navigation solution produced by the local strap-down navigation processor, the local Kalman filter further coupled to a master Kalman filter;wherein the local Kalman filter receives a first message from the master Kalman filter comprising a Precision Transfer Alignment Message (PTAM) that includes at least one navigation aid measurement;wherein the local Kalman filter inputs the navigation aid measurement into a measurement formation algorithm and calculates a measurement residual based ...

PROJECT ACTIVITY MODEL

A system and method for creating a project workflow involves tracking all activities from all disciplines within a company in a database, such that when a new workflow is created, a project architect is forced to consider every activity ever performed to the workflow in relation to every discipline. Only after activities have been assigned to their appropriate disciplines, can a user filter a view of the map to hide disciplines and activities from view. This ensures that every task ever performed by various disciplines within a company is always considered whenever designing a project workflow. 1. A method of producing a visual map of a project management workflow , comprising:collecting past activities from at least three disciplines into a database;populating the map with a plurality of past activities from a plurality of disciplines in the database;protecting the past activities to prevent user deletion of a past activity from the map; andproviding a user interface that allows a user to (a) alter a visual characteristic of a past activity, and (b) delete a discipline from the map.2. The method of producing the visual map of claim 1 , further comprising providing a legend of visual characteristics for the activities.3. The method of producing a visual map of claim 2 , further comprising permanently write-protecting the legend to prevent deletion of a visual characteristic.4. The method of producing a visual map of claim 2 , further comprising providing a user interface that allows a user to change a visual characteristic of the legend.5. The method of producing a visual map of claim 2 , wherein a visual characteristic of the legend represents at least two participants.6. The method of producing a visual map of claim 5 , further comprising providing a user interface that allows a user to alter a visual characteristic of a past activity to show percentage of work each participant is responsible for.7. The method of producing a visual map of claim 1 , further ...

SYSTEM AND METHOD FOR MODULAR PHOTOVOLTAIC POWER

A prefabricated array of photovoltaic modules mechanically assembled to a frame and pre-wired at an assembly location such as a factory and is transported to an installation location. The prefabricated array is wired so that a connection to a load, such as a home or an AC power delivery system can be accomplished by connecting a single connector to the load. The prefabricated array can be conveniently set up at the installation site using a lifting point attached to the array, for example at the frame. The time required to perform the installation and make the necessary electrical connections to make the array operable when illuminated can be as short as one hour. 1. A method of installing a prefabricated array of photovoltaic modules , comprising the steps of:providing at an installation location a prefabricated array of photovoltaic modules, said prefabricated array of photovoltaic modules having a frame with a plurality of photovoltaic modules mechanically connected to said frame, each of said plurality of photovoltaic modules comprising one or more photovoltaic solar cells, each of said plurality of photovoltaic modules configured to generate at least 50 Watts of electrical power under an illumination level of 1 kiloWatt per square meter, said prefabricated array of photovoltaic modules having an electrical connector mechanically connected to said frame and configured to provide electrical power output terminals, said prefabricated array of photovoltaic modules configured to be transported from a first location different from said installation location, with an electrical connection to said prefabricated array of photovoltaic modules to be made at said installation location by way of said electrical connector;disposing said prefabricated array of photovoltaic modules in a working orientation at said installation location; andmaking an electrical connection between said prefabricated array of photovoltaic modules and an electrical load by way of said electrical ...

SYNTHESIS OF RESVERATROL-BASED COMPOUNDS

A compound having the structure: This application claims priority of U.S. Provisional Application No. 61/400,111, filed Jul. 21, 2010, the contents of which are hereby incorporated by reference.Throughout this application, various publications are referenced by citation in parentheses. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art as known to those skilled therein as of the date of the invention described and claimed herein.The past decade has witnessed tremendous interest in the relatively small natural product resveratrol (1, ) based primarily on its possession of a promising and selective array of in vitro and in viva activity against a collection of disease states, including inflammation, heart disease, aging, and cancer [1]. In fact, its truly unique biochemical profile, coupled with its relatively high concentration in red wine (˜100 mM) and near absence in white varietals and grape juice, has led to the popularly held notion that resveratrol is the main protagonist for the so-called “French paradox” [2]. Amazingly, however, virtually no effort has been devoted to the large family of resveratrol-based oligomers (such as 2-8) [3] produced combinatorially by plants throughout the world in response to environmental stress, compounds which initial screening suggest should have unique, if not superior, activity profiles to resveratrol itself [4].In one embodiment, this invention provides a compound having the structureThis invention provides a compound having the structureIn some embodiments, the invention includes the compound wherein in the compound each occurrence of Ris independently H, CH, C(O)CH, P(O)(OR), SOOR, SOR, or C(O)R,In some embodiments, the invention includes the compound wherein in the compoundIn some embodiments, the invention includes the compoundwherein the structure isor a salt thereof.In some embodiments, the invention ...

PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS

A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator. 1. A process for controlling concentrations of CO in an aqueous fermentation medium , the process comprising contacting part of the fermentation medium with at least one CO binding ligand and measuring an amount of CO bound to the CO binding ligand.2. The process of wherein part of the fermentation medium is contacted with the CO binding ligand and with a microbial inactivator.3. The process of wherein the CO concentration in the aqueous fermentation medium is maintained from about 2 μM or more to about 10 μM or less.4. The process of wherein the CO bonding ligand is selected from the group consisting of hemoglobin claim 1 , myoglobin claim 1 , free heme claim 1 , heme containing compounds and mixtures thereof.5. The process of wherein the microbial inactivator is selected from the group consisting of salt claim 2 , acid claim 2 , base claim 2 , organic solvent claim 2 , oxidizing agents claim 2 , heat claim 2 , cold and mixtures thereof.6. The process of wherein the amount of CO bound to the CO binding ligand is measured by determining changes in absorbance.7. A process for controlling concentrations of CO in a bioreactor that includes an aqueous fermentation medium claim 1 , the process comprising:contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator; andmeasuring an amount of CO bound to the CO binding ligand.8. The process of wherein if the amount of CO bound to the CO binding ligand corresponds to a concentration of CO in the fermentation medium of about 10 μM or more claim 7 , then a feed rate of CO to the bioreactor is decreased.9. The process of wherein if ...

PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO

A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 μM or less. 1. A syngas fermentation process comprising:providing syngas to a first fermentation zone;fermenting the syngas; anddetermining a CO concentration in a fermentation medium in the first fermentation zone,wherein if the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of at least about 0.12 μM or less.2. The process of wherein a CO concentration is determined by contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator claim 1 , and measuring an amount of CO bound to the CO binding ligand.3. The process of wherein the CO bonding ligand is selected from the group consisting of hemoglobin claim 2 , myoglobin claim 2 , free heme claim 2 , heme containing compounds and mixtures thereof.4. The process of wherein the microbial inactivator is selected from the group consisting of salt claim 2 , acid claim 2 ...

CHILD RESISTANT ZIPPER CLOSURE SYSTEM AND ROCKABLE SLIDER DEVICE AND METHODS

A slider for a zipper closure includes a separator plow that is positionable between interlocking tracks of the zipper closure to open the zipper closure by pivoting an opening end of the slider in a direction toward a notch to position the plow between the interlocking closures. The slider can be disengaged by pivoting the slider so that the plow is outside of the interlocking tracks. 1. A slider for a zipper closure having interlocking members with complementary profiles for interlocking and unlocking; the slider comprising:(a) an opposite opening end and closing end;(b) a top member;(c) a pair of spaced legs depending from the top member; the spaced legs defining an open volume therebetween to allow for passage of the tracks therethrough and with the legs straddling the tracks;(d) internal surfaces spaced sufficiently close together in a vicinity of the closing end to press the profiles into interlocking relationship as the slider is moved in a closing direction along the zipper closure; and(e) a separator plow extending from the opening end; the separator plow being selectively moveable into a position to be between the interlocking members and separate the interlocking profiles as the slider is moved in an opening direction along the zipper closure by pivoting the opening end of the slider in a direction toward the profiles.2. The slider of further comprising a protrusion extending from at least one of the legs into the open volume toward the opposite leg.3. The slider of wherein the protrusion is in the vicinity of the opening end.4. The slider of wherein at least one leg has a first track-accommodating groove and a second track-accommodating groove; the first and second track-accommodating grooves being separated by the protrusion.5. The slider of wherein the first track-accommodating groove and second track-accommodating groove are angled relative to each other at an angle greater than 0° and less than 90°.6. The slider of wherein the first track- ...

VISCOELASTIC FOAM

Recovery time and/or airflow of flexible polyurethane foam is increased by including certain tackifiers in the foam formulation. The tackifiers are characterized in being incompatible with polyol or polyol mixture used to make the foam, having a viscosity of at least 10,000 centipoise at 25° C., having a glass transition temperature of at most 15° C. and being inert to other components of the foam formulation. 1. A flexible polyurethane foam having internal surfaces which are partially coated with a tackifier , wherein the tackifier layer occupies 1 to 75% of the surface area of the internal surfaces.2. The flexible polyurethane foam of wherein the tackifier occupies 2.5 to 40% of the surface area of the internal surfaces.3. The flexible polyurethane foam of wherein the tackifier is present on the internal surfaces of the polyurethane foam in the form of discontinuous regions having longest dimensions of 10 nm to 200 μm.4. The flexible polyurethane foam of wherein the longest dimensions are at least 100 nm and up to 50 μm.5. The flexible polyurethane foam of wherein the tackifier includes one or more of a rosin claim 1 , a hydrogenated and/or esterified rosin claim 1 , a polyterpene claim 1 , a C5 aliphatic resin claim 1 , a C9 aromatic resin claim 1 , a C5/C9 copolymer resin claim 1 , a hydrogenated C5 or C9 resin claim 1 , a polymer or copolymer of butene claim 1 , an epoxy resin claim 1 , a styrene/conjugated diene copolymer such as styrene/butadiene copolymer and styrene isoprene copolymer claim 1 , an ethylene-acrylic acid copolymer claim 1 , an ethylene-higher alpha-olefin copolymer having a density of less than 0.900 g/cc a silicone oil claim 1 , a cellulosic claim 1 , cationic polyacrylamide claim 1 , para-t-octyl phenol formaldehyde resin claim 1 , a polyester having a number average molecular weight of 400 to 2000 claim 1 , a urethane acrylate oligomer and a room temperature liquid ethylene-propylene-diene resin.6. A method of making a flexible ...

MINIATURE HIGH PERFORMANCE SOLENOID VALVE

A solenoid valve assembly includes an armature having a longitudinal axis and an ovular cross-section, the armature being moveable along the longitudinal axis from a first position to a second position, and a bobbin including a solenoid coil configured to electromagnetically move the armature when energized. The bobbin defines a recess also having an ovular cross section for receiving the armature and restricting lateral movement of the armature, thereby providing a linear actuation path for the armature along the longitudinal axis. A flux coupler and a flux bracket form a magnetic circuit with the bobbin to electromagnetically move the armature. The flux bracket has a pole piece with a commensurate ovular cross-section that limits the movement of the armature along the longitudinal axis, thereby determining a stroke length of the armature. During manufacture, the flux bracket, and therefore the pole piece, are moved relative to the flux coupler to set the stroke length. 1. A solenoid valve assembly comprising:an armature having a longitudinal axis, the armature being moveable along the longitudinal axis from a first position to a second position; anda bobbin including a solenoid coil configured to electromagnetically move the armature along the longitudinal axis from the first position to the second position when energized;wherein the armature has an ovular transverse cross section.2. The solenoid valve assembly of claim 1 , wherein the ovular transverse cross section of the armature has an aspect ratio of greater than 3:1.3. The solenoid valve assembly of claim 1 , wherein the bobbin defines a recess having an ovular cross section for receiving the armature and restricting lateral movement of the armature claim 1 , thereby providing a linear actuation path for the armature along the longitudinal axis.4. The solenoid valve assembly of claim 3 , wherein the recess of the bobbin includes a plurality guiding ribs configured to provide an area for shed material to ...

Smoothed navigation solution using filtered resets

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

CONTROLLING DISCLOSURE OF IDENTITIES IN COMMUNICATION SESSIONS

Technologies are disclosed for a computing system that allows users to control the disclosure of their identities during communication sessions. Users can control the disclosure of their identities with respect to certain types of shared content. In one mode of operation, a user can share content anonymously. In another mode of operation, identity may be revealed when certain conditions are met or revealed to only certain other users. For example, the identity of a user who shared a comment anonymously may be revealed if multiple other users agree with that comment. In another mode of operation, the user's identity is revealed to all other users such as in a live video stream. The computing system can control display of users' identities based on user instructions or based on triggering conditions. A user interface (UI) can show content items that identify a user together with content items that are shared anonymously.

COMPACT INERTIAL MEASUREMENT UNIT WITH INTERFACE ADAPTER

Systems and method for reducing the size of inertial measurement units are disclosed. In one embodiment, an inertial measurement unit assembly comprises: at least one inertial sensor configured to output uncompensated sensor data; an inertial isolator configured to isolate the at least one inertial sensor; an interface adapter, wherein the interface adapter includes at least one calibration alignment pin that is used as a reference point between the at least one inertial sensor, the inertial interface adapter and a vehicle to which the inertial interface adapter is attached. Furthermore, the inertial measurement unit is configured to output the uncompensated sensor data to a processing device located external to the inertial measurement unit. 1. An inertial measurement unit assembly comprising:at least one inertial sensor configured to output uncompensated sensor data;an inertial isolator configured to isolate the at least one inertial sensor;an interface adapter, wherein the interface adapter includes at least one calibration alignment pin that is used as a reference point between the at least one inertial sensor, the inertial interface adapter and a vehicle to which the inertial interface adapter is attached; andwherein the inertial measurement unit is configured to output the uncompensated sensor data to a processing device located external to the inertial measurement unit.2. The inertial measurement unit of claim 1 , further comprising a spanner nut configured to secure the one or more inertial sensors to the interface adapter.3. The inertial measurement unit of claim 1 , wherein the inertial measurement unit is configured to output the uncompensated sensor data to the processing device over an asynchronous serial data stream.4. The inertial measurement unit of claim 1 , further comprising memory configured to store a plurality of calibration coefficients; andwherein the inertial measurement unit is configured to output the plurality of calibration coefficients ...

Biometrics and predictive modeling and monitoring system for health risk assessment

The present invention relates to methods and apparatus for generating create and maintain very efficient ‘preferred collateralized risk health plans’ with very rich benefit offerings at the best price points possible. More specifically, the present invention presents methods and apparatus for generating a means for providing health care services to smaller groups of participants by grouping like participants into larger plan groups.

SYSTEM AND METHOD FOR COMMUNICATING INFORMATION IN A LOCATION-BASED SYSTEM

Systems and methods are provided that permit merchants, venue owners, and other entities defined within a location-based system to communicate with users. Additional communication capabilities are provided in a location-based service that permits merchants and other entities to engage users in different ways. One or more advertisers, merchants or other entities may be able to send messages to one or more users. For instance, if a user visits a venue more than a certain number of times in total, visits or “checks-in” to that venue over a period of time, indicates that the user follows or “likes” a particular venue or merchant, or performs some other activity with the location-based network, that merchant may be provided a vehicle for sending messages to those users. Targeted messages may be sent responsive to any information used in the location-based service, including active or passive user activity. 1. A method for presenting information to a user by a location-based system , the method comprising acts of:creating, by a merchant associated with a venue, a message to be communicated to one or more users in the location-based system;storing the message in the location-based system;determining user activity associated with a user in the location-based system;determining, based on the user activity in the location-based system, whether the message should be communicated to the user; andif so, communicating the message to the user.2. The method according to claim 1 , wherein the user activity includes at least one of a group of user activities comprising:a check-in to the venue;a “like” of the venue;travel by the user to a location within a distance or area of the venue; andan action performed by the user in a location-based system.3. The method according to claim 1 , wherein the act of determining whether the message should be communicated to the user further comprises an act of determining if the user provided an indication that the user would like to receive ...

Trainer

A trainer is disclosed which is useful for developing skill in sports of coordination including for instance beer-pong. 1. A game system comprising; a plurality of tubes co-planar apertures disposed at the dorsal ends thereof thereby defining entrances , with the interior volume of the tubes in communication with a tray; wherein a distal-end portion of the tray is elevated relative to a proximal-end portion of the tray such that a ball entering one of the entrances will fall and roll eventually to the proximal-end portion of the tray.2. The game system of claim 1 , wherein the tubes are removable from the tray by means of magnets claim 1 , hook and loop fasteners claim 1 , press fitting claim 1 , a bayonet mount claim 1 , or a thread.3. The game system of claim 1 , wherein the tray is disposed within a hollow volume claim 1 , thereby defining a base.4. The game system of claim 3 , wherein there is an aperture disposed upon the surface of the base in communication with the tray and apertures at the dorsal ends of the tubes thereby defining an exit such that a ball released in an entrance will eventually fall and roll to the exit.5. The game system of claim 4 , wherein the exit is disposed centrally to the proximal-end portion of the base.6. The game system of claim 4 , wherein the exit is disposed upon opposing claim 4 , lateral sides of the base.7. The game system of claim 1 , wherein the color of the tubes is selected to approximate the clear claim 1 , red claim 1 , blue claim 1 , or white of Solo Plastic Party Cold® drinking cups.8. The game system of claim 1 , wherein the tubes have an inverse frustoconical taper claim 1 , with the taper being selected from the range of 1 and 30 degrees from long axis of each tube.9. The game system of claim 1 , wherein the smaller diameter of a given tube is between the range of 1 and 4 inches.10. The game system of claim 1 , wherein the diameter of a given tube is selected to approximate that of a 20 ounce claim 1 , 16 ounce ...

CHARGE AIR COOLER COVER AND TURBOCHARGER BRACKET

A charge air cooler cover includes a nozzle configured for connection to an outlet of a compressor for receiving charge air, a tray configured for connection to an inlet of a charge air cooler, and a plenum leading from the nozzle to a plurality of passages defined by a plurality of ribs. The plurality of passages connects the plenum to the tray. The ribs and the tray are arranged to achieve substantially uniform charge air velocity across the inlet of the charge air cooler, in at least one mode of operation. 1. A charge air cooler cover comprising:a nozzle configured for connection to an outlet of a compressor for receiving charge air;a tray configured for connection to an inlet of a charge air cooler; anda plenum leading from the nozzle to a plurality of passages defined by a plurality of ribs, the plurality of passages connecting the plenum to the tray.2. The charge air cooler cover of claim 1 , wherein the ribs and the tray are arranged to achieve substantially uniform charge air velocity across the inlet of the charge air cooler.3. The charge air cooler cover of claim 2 , wherein the plurality of ribs define the plurality of passages to have differing flow areas claim 2 , the respective flow area of each passage depending on distance of that passage from the nozzle.4. The charge air cooler cover of claim 3 , wherein the passage furthest from the nozzle is defined to have the largest flow area among the plurality of passages.5. The charge air cooler cover of claim 2 , wherein the plurality of ribs define the plurality of passages to have differing flow areas claim 2 , wherein a first of the plurality of passages furthest from the nozzle is defined to have the largest flow area among the plurality of passages and a second of the plurality of passages closest to the nozzle is defined to have the smallest flow area among the plurality of passages.6. The charge air cooler cover of claim 2 , wherein the tray slopes inward from the plurality of passages across the ...

AUTONOMIC OPTIMIZATION OF PRESENCE SERVER PERFORMANCE

A presence system comprises a presence server and a plurality of users in a distributed community of users that are associated with the presence server. The presence server selects a set of mediators, e.g., based upon a predetermined event, or other suitable factors, wherein each mediator is associated with a subset of the plurality of users. The presence server communicates presence information to the mediators where each mediator receives presence information regarding subscribed-to presence information for the users in their associated subset of users. Each mediator communicates the subscribed-to presence information to associated ones of the users in their associated subset of users. 1. A presence system comprising:a computer processor; and a module to associate a plurality of users in a distributed community of users with a presence server, where each user communicates across a network using a computer processing device;', 'a module to identify subsets of users from said plurality of users;', 'a module to select a set of mediators used to communicate presence information between said presence server and said plurality of users;', 'a module to assign each mediator to an identified subset of users;', 'a module to communicate presence information from said presence server to select mediators in said set of mediators to service said subset of users assigned to the selected mediator, where each selected mediator receives presence information regarding subscribed-to presence information for users in said subset of users assigned to the selected mediators; and', 'a module to communicate subscribed-to presence information from each selected mediator in said set of mediators to associated ones of said users in said subset of users assigned to the selected mediator to keep said users in said subset of users up to date with their subscribed-to presence information., 'a memory in communication with the computer processor storing instructions that when executed by the ...

Curved Catheter and Methods for Making Same

A pre-curved catheter tube of a catheter assembly or other elongate medical device and methods for forming such a device using a heating procedure is disclosed. Pre-curving of the catheter tube is desirable to impart to the catheter assembly a desired positional configuration when the catheter assembly is inserted into a patient. The heating procedure may include heat sterilization procedures commonly used to sterilize medical devices prior to use. In one embodiment, therefore, a catheter assembly is disclosed, comprising an elongate catheter tube defining at least one lumen, and a tube constraint. The tube constraint is included with the catheter assembly and is configured to temporarily constrain the catheter tube in a curved configuration during a heating procedure of the catheter assembly so as to permanently form the catheter tube in the curved configuration after the heating procedure is complete and the catheter tube is released from the tube constraint. 1. A catheter assembly , comprising:an elongate catheter tube defining at least one lumen; anda tube constraint included with the catheter assembly that temporarily constrains the catheter tube in a curved configuration during a heating procedure of the catheter assembly to permanently maintain the catheter tube substantially in the curved configuration after the heating procedure is complete and the catheter tube is released from the tube constraint.2. The catheter assembly as defined in claim 1 , wherein the heating procedure includes a heat sterilization procedure.3. The catheter assembly as defined in claim 2 , wherein the heating procedure includes an ethylene oxide sterilization procedure.4. The catheter assembly as defined in claim 3 , wherein the ethylene oxide sterilization procedure is performed at a temperature of at least about 55 degrees Celsius.5. The catheter assembly as defined in claim 5 , wherein the ethylene oxide sterilization procedure is performed for a time of at least about 15 minutes. ...

Low-Profile Access Port

A low-profile access port for subcutaneous implantation within the body of a patient is disclosed. The access port includes a receiving cup that provides a relatively large subcutaneous target to enable a catheter-bearing needle to access the port without difficulty. In addition, the access port includes a valve/seal assembly to permit pressurized fluid injection through the port while preventing backflow. In one embodiment, therefore, a low-profile access port comprises a body including a conduit with an inlet port at a proximal end thereof, and a receiving cup. The receiving cup is concavely shaped to direct a catheter-bearing needle into the conduit via the inlet port. The receiving cup is oriented substantially toward a skin surface when subcutaneously implanted within the patient to ease needle impingement thereon. A valve/seal assembly disposed in the conduit enables passage of the catheter therethrough while preventing fluid backflow. 1. A low-profile access port for subcutaneous placement in a patient , comprising: a conduit including an inlet port at a proximal end thereof; and', 'a receiving cup in communication with the inlet port, the receiving cup concavely shaped to direct a catheter-bearing needle into the conduit via the inlet port, the receiving cup oriented substantially toward a skin surface when subcutaneously implanted within the patient; and, 'a body includinga valve/seal assembly disposed in the conduit that enables passage of the catheter therethrough.2. The access port as defined in claim 1 , wherein the conduit includes a first conduit portion and a second conduit portion claim 1 , the second conduit portion positioned distal to and at an angled orientation with respect to the first conduit portion so as to prevent passage of the needle of the catheter-bearing needle while permitting passage of the catheter.3. The access port as defined in claim 2 , wherein the second conduit portion is disposed at an angle less than about 37 degrees with ...

MINIATURE VACUUM/PRESSURE DIAPHRAGM PUMPS WITH NOISE MITIGATION BOOT

A noise mitigation boot that can be installed on or integrated into a miniature diaphragm pump to reduce the overall noise and improve sound quality during operation. The diaphragm pump includes a housing having first and second ports and an interior chamber, a pumping diaphragm disposed in the interior chamber and dividing the interior chamber into a pumping chamber and a backside chamber, a motor for reciprocating the pumping diaphragm for pumping air into and out of the pumping chamber, and flow passages connecting the pumping chamber to the first and second ports. The first port is configured for attachment to a flow line and the second port opens to an exterior surface of the housing. The noise mitigation boot has a muffler wall overlying the exterior surface of the housing. The muffler wall has formed therein a passage extending from the second port to the backside chamber for effecting fluid communication between the second port and the backside chamber. 1. A diaphragm pump assembly comprising:a diaphragm pump; anda muffler wall disposed on at least one side of the diaphragm pump;wherein the diaphragm pump includes a housing having first and second ports and an interior chamber, a pumping diaphragm disposed in the interior chamber and dividing the interior chamber into a pumping chamber and a backside chamber, a motor for reciprocating the pumping diaphragm for pumping air into and out of the pumping chamber, and flow passages connecting the pumping chamber to the first and second ports,wherein the second port opens to an exterior surface of the housing; and wherein the muffler wall overlies the exterior surface of the housing, the wall having formed therein a passage extending from the second port to the backside chamber for effecting fluid communication between the second port and the backside chamber.2. The diaphragm pump assembly of claim 1 , wherein the muffler wall is part of a noise mitigation boot attached to the diaphragm pump.3. The diaphragm pump ...

Process to control co concentrations in fermentations

A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

TOUCHSCREEN INTERFACE MENU WITH VIRTUAL WHEEL

Items may be displayed on a selection list and at least a portion of a virtual wheel displayed on a user interface. The selection list and virtual wheel may be configured to operate in conjunction with one another. The virtual wheel may be rotationally repositioned by a first input received at the user interface to change items displayed concurrently with the rotation of the virtual wheel. A second input received at the user interface may be used to select one of the items displayed on the at least a portion of the virtual wheel as a selection associated with an item displayed on the selection list for further processing. As selections are made on the virtual wheel the selection list displays selections being made to provide a status of activity using the virtual wheel. 1. A device comprising:a user interface for receiving input and presenting output, and having a display; and display a plurality of items on at least a portion of a virtual wheel on the display;', 'display a selection list on the display, the selection list including information associated with at least one of the plurality of items on the virtual wheel;', 'receive a first input at the user interface, and in response to the first input, rotationally reposition the virtual wheel to change a display position of the plurality of items concurrent with the rotational repositioning of the virtual wheel;', 'receive a second input at the user interface, the second input selecting at least one of the plurality of items from the virtual wheel for processing; and,', 'display, in response to receiving the second input, an indication in the selection list of the at least one of the plurality of items selected for processing., 'a processor and memory including code, the code executable to cause the processor to control the device to2. The device of claim 1 , wherein the code is further executable to cause the processor to control the device to display the selection list adjacent to the virtual wheel claim 1 , ...

UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY

This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is: 1122-. (canceled)124. A process for cyclizing an alkene or halogenating an aromatic ring comprising contacting the alkene or aromatic ring with the compound of under conditions permitting cyclization of the alkene or halogenation of the aromatic ring.125. The process of claim 124 , wherein the alkene is a polyene claim 124 , alkenoic acid or alkenyl alkyl ether.126. The process of claim 124 , wherein the cyclization is a ring-forming halolactonization or ring-expanding bromoetherification.127. The process of claim 124 , wherein the halogenation is a mono-halogenation and the aromatic ring is a substituted phenyl. This application claims priority of U.S. Provisional Application No. 61/403,406, filed Sep. 14, 2010, the contents of which are hereby incorporated by reference.The work disclosed herein was made with government support under Grant No. CHE0844593 from the National Science Foundation and Grant No. GM-084994 from the National Institutes of Health. Accordingly, the U.S. Government has certain rights in this invention.Throughout this application, certain publications are referenced in parentheses. Full citations for these publications may be found immediately preceding the claims. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to describe more fully the state of the art to which this invention relates.With little question, the ability to convert polyene starting materials into far more complex frameworks via stereoselective cation-π cyclizations constitutes one of the most ...

Methods for the Production of 3-O-Deactivated-4'-Monophosphoryl Lipid A (3D-MLA)

Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting, cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-O-deacylated monophosphoryl lipid A (3D-MLA) having at least about 20 mol % of the hexaacyl congener group. 1. A method of extracting lipopolysaccharide (LPS) from a culture of deep rough mutant bacterial strain cells , comprising:a. Extracting the cells with a solution consisting essentially of at least 75 wt % of an aliphatic alcohol having from 1 to 4 carbon atoms and the balance water, thereby producing cells with reduced phospholipid content;b. Extracting the cells with reduced phospholipid content with a solution comprising chloroform and methanol, thereby yielding a solution of LPS in chloroform and methanol,wherein the extracting with aliphatic alcohol is performed at a temperature between 35° C. and 65° C.2SalmonellaEscherichia.. The method of claim 1 , wherein the deep rough mutant bacterial strain is of the genera or3SalmonellaSalmonella minnesota.. The method of claim 2 , wherein the deep rough mutant bacterial strain of genus is of species4Salmonella minnesotaSalmonella minnesota. The method of claim 3 , wherein the deep rough mutant bacterial strain of species is strain R595.5EscherichiaEschenchia coli.. The method of claim 2 , wherein the deep rough mutant bacterial strain of genus is of species6Escherichia coilEscherichia coil. The method of claim 5 , wherein the deep rough mutant bacterial strain of species is of strain D31m4.7. The method of claim 1 , wherein the aliphatic alcohol has from 2 to 4 carbon atoms.8. The method of claim 7 , wherein the aliphatic alcohol is ethanol.9. The method of claim 1 , wherein the solution comprising aliphatic alcohol comprises ...

Improved Therapeutic Regimen for Hypertension

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension. 1. A kit comprising: binding entities or probes for detecting different polypeptide or nucleic acid segments , respectively , wherein each of the binding entities and/or probes selectively binds to one of the following targets: a. wherein the ADRI3T polypeptide as a serine or glycine at position 49;', 'b. wherein the ADRI3T polypeptide has an arginine or glycine at position 389;', 'c. wherein the ADRB1 nucleic acid comprises rs1801252 (SEQ ID NO:2) with an adenine or guanine at the rs1801252 variable position; and/or', 'd. wherein the ADRB1 nucleic acid comprises rs1801253 (SEQ ID NO:3) with a cytosine or guanine at the rs1801253 variable position;, 'a) ADRB1 as a target 1. wherein the ADRB2 (2A) polypeptide has a glycine or arginine at position 16;', '2. wherein the ADRB2 polypeptide has glutamic acid or glutamine at position 27;', '3. wherein the ADRB2 nucleic acid comprises rs1042713 (SEQ ID NO:6) with or an adenine or a guanine at the rs1042713 variable position; and/or', '4. wherein the ADRB2 nucleic acid comprises rs1042714 (SEQ ID NO:7) with a cytosine or a guanine at the rs1042714 variable position;, 'b) ADRB2 as a target a. wherein the CYP2D6 nucleic acid encodes a CYP2D6-defective gene product; and/or', 'b. wherein the CYP2D6 nucleic acid comprises rs3892097 (SEQ ID NO:10) with an adenine or a guanine at the rs3892097 variable position;, 'c) CYP2D6 as a target 1. wherein the angiotensin polypeptide has methionine or threonine at position 268; and/or', '2. wherein the angiotensin (AGT) nucleic acid comprises rs699 (SEQ ID NO:14) with cytosine or thymine at the AGT variable position;, 'd) angiotensin (AGT) as a targete) angiotensin receptor type-I (AGT1R) as a target, wherein the angiotensin receptor type-I (AGT1R) nucleic acid comprises rs5186 (SEQ ID NO:16) at least partially in an AGT1R ...

SMOOTHED NAVIGATION SOLUTION USING FILTERED RESETS

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution. 1. A navigation system comprising:at least one inertial sensor configured to detect motion of the system and generate inertial data;at least one aiding device configured to generate aiding device measurement data;at least one processing unit configured to generate an un-smoothed navigation solution based on the inertial data and the aiding device measurement data, the un-smoothed navigation solution inclusive of state variable error resets for a state variable;wherein the at least one processing unit is further configured to sum the state variable error resets for the state variable into a cumulative sum of the state variable error resets for the state variable;wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets for the state variable; andwherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets for the state variable from the un-smoothed navigation solution to ...

Therapeutic Regimen for Hypertension

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension. 165-. (canceled)68. A method according to wherein the DNA analyses are conducted sequentially or simultaneously.69. A method according to wherein the DNA analyses are conducted simultaneously.70. A method according to wherein the DNA and/or polypeptide analyses are conducted sequentially or simultaneously.71. A method according to wherein the DNA and/or polypeptide analyses are conducted simultaneously.72. A method according to comprising administering to the patient a second line antihypertensive drug after administration of the first line drug administration for at least one month wherein the second line drug is selected from the group consisting of diuretic claim 66 , a beta-blocker claim 66 , an ACE inhibitor claim 66 , a vasodilator and a combination thereof claim 66 , and the second line drug is not the same as the first line drug.73. A method according to wherein at least one additional polymorphism is present in the patient's one or more DNA sequences corresponding to DNA sequences 1-14 and the administration procedures are the same as those of procedures a-f.74. A method according to wherein a diuretic is furosemide claim 66 , a thiazide claim 66 , a carbonic anhydrase inhibitor claim 66 , an aldosterone antagonist claim 66 , spironolactone claim 66 , eplerenone claim 66 , potassium canreonate claim 66 , amiloride claim 66 , triamterene claim 66 , aldactone claim 66 , acetazolamide claim 66 , amiloride claim 66 , bumetanide claim 66 , chlorothalidone claim 66 , chlorothiazide claim 66 , ethacrynic acid claim 66 , furosemide claim 66 , glycerin claim 66 , hydrochlorothiazide claim 66 , hydroflumthiazide claim 66 , indapamide claim 66 , isosorbide claim 66 , mannitol claim 66 , methazolamide claim 66 , methylchlothiazide claim 66 , metolazone claim 66 , dichlorphenamide claim 66 , ...

ENERGY HARVESTER FOR CONVERTING VIBRATIONAL MOTION OF A VIBRATING EQUIPMENT INTO ELECTRICAL ENERGY, AND A DEVICE FOR MONITORING THE OPERATION OF A VIBRATING EQUIPMENT

The invention relates to an energy harvester for converting vibrational motion of a vibrating equipment into electrical energy. The energy harvester comprises a pendulum arranged to be pivotably attached to said vibrating equipment, a motion limiter arranged to limit a pivoting motion of said pendulum, and a generator connected to said pendulum and arranged to convert said pivoting motion into electrical energy. The vibrational motion has an operating frequency, and said pendulum has a natural frequency different from said operating frequency. The invention also relates to a device for monitoring the operation of a vibrating equipment. 1. An energy harvester for converting vibrational motion of a vibrating equipment into electrical energy , comprising:a pendulum arranged to be pivotably attached to said vibrating equipment;a motion limiter arranged to limit a pivoting motion of said pendulum; anda generator connected to said pendulum and arranged to convert said pivoting motion into electrical energy,said vibrational motion having an operating frequency, and said pendulum having a natural frequency different from said operating frequency.2. An energy harvester according to claim 1 , further comprising at least one spring element having a first and a second end claim 1 , said first end being attached to said pendulum and said second end being arranged to rebound against said motion limiter.3. An energy harvester according to claim 1 , wherein said motion limiter comprises a first bar element provided on one side of said pendulum and a second bar element provided on the other side of said pendulum.4. An energy harvester according to claim 3 , further comprising a first spring element having a first and a second end claim 3 , said first end being attached to said pendulum and said second end being arranged to rebound against said first bar element claim 3 , and a second spring element having a first and a second end. said first end being attached to said pendulum and ...

METHODS FOR QUANTIFYING STARCH CELLULOSE IN CORN SAMPLES

Solutions and methods are disclosed for the extraction and quantification of cellulose derived from cellulosic biomass samples. Improved extraction yields and selectivities are provided through the use of an extraction solvent mixture comprising an aprotic solvent such as DMSO, a quaternary ammonium salt such as TBAF, and an quaternary ammonium base such as TBAOH. The extracted cellulose can be optionally precipitated using disclosed precipitation solutions to further improve cellulose purity. Extracted cellulose can be measured by hydrolyzing the cellulose to glucose or cellobiose, or by using disclosed spectrophotometric assays of cellulose-salt complexes. 1. A cellulose extraction solution comprising:a cellulosic biomass sample; anda solvent mixture comprising a polar aprotic solvent, a quaternary ammonium salt, and a quaternary ammonium base.2. The cellulose extraction solution of claim 1 , wherein the polar aprotic solvent is DMSO.3. The cellulose extraction solution of claim 1 , wherein the quaternary ammonium salt is TBAF.4. The cellulose extraction solution of claim 1 , wherein the quaternary ammonium base is TBAOH.5. The cellulose extraction solution of claim 1 , wherein the concentration of the quaternary ammonium salt in the solvent mixture is from 10 mg/mL to 500 mg/mL.6. The cellulose extraction solution of claim 1 , wherein the concentration of the quaternary ammonium base is from 1 mg/mL to 1500 mg/mL.7. The cellulose extraction solution of claim 1 , wherein the mass ratio of the quaternary ammonium salt to the quaternary ammonium base is from 0.05 to 15.8. The cellulose extraction solution of claim 1 , wherein the amount of the solvent mixture is from 1 mL to 50 mL per gram of cellulosic biomass.9. The cellulose extraction solution of claim 1 , further comprising one or more saccharifying enzymes.10. The cellulose extraction solution of claim 9 , further comprising glucose produced in a chemical reaction catalyzed by the one or more saccharifying ...

Curved Catheter And Methods For Making Same

A pre-curved catheter tube of a catheter assembly or other elongate medical device and methods for forming such a device using a heating procedure is disclosed. Pre-curving of the catheter tube is desirable to impart to the catheter assembly a desired positional configuration when the catheter assembly is inserted into a patient. The heating procedure may include heat sterilization procedures commonly used to sterilize medical devices prior to use. One method for curving a catheter tube of a catheter assembly includes constraining the catheter tube into a curved configuration using the tube constraint, heating the catheter tube in the curved configuration for a predetermined time at a predetermined temperature, and releasing the catheter tube from the tube constraint after the heating is complete.

Connection Systems And Methods Thereof For Establishing Electrical Connections Across A Sterile Field

Disclosed herein are connection systems for establishing electrical connections across a sterile field. An example connection system includes a sensor connector, a probe connector, and a tether having a first end connected to the sensor connector and a second end connected to the probe connector. The sensor connector includes a piercing element. The piercing element is configured to pierce a sterile side of a drape and establish a first electrical connection with a receptacle of a sensor when the piercing element is inserted into the receptacle. The probe connector includes a probe-connecting means configured for a user to establish a second electrical connection between an electrical contact of the probe connector and a wire probe. The tether is configured to convey electrical signals between the sensor connector and the probe connector. Also disclosed herein are methods of connection systems for establishing electrical connections across a sterile field. 1. A connection system for establishing electrical connections across a sterile field , the connection system comprising:a sensor connector including a piercing element, the piercing element configured to pierce a sterile side of a drape and establish a first electrical connection with a receptacle of a sensor when the piercing element is inserted into the receptacle;a probe connector including a probe-connecting means configured for a user to establish a second electrical connection between an electrical contact of the probe connector and a wire probe; anda tether having a first end connected to the sensor connector and a second end connected to the probe connector, the tether configured to convey electrical signals between the sensor connector and the probe connector.2. The connection system of claim 1 , wherein the probe-connecting means is a non-directional clamp configured to clamp the wire probe in any user-chosen orientation of a nearly unlimited number of orientations of the wire probe to the non- ...

Structured Arrangements for Tracking Content Items on a Shared User Interface

Technologies are disclosed that enable a computing system to present a structured arrangement for tracking content items on a shared user interface (UI) during a communication session. The structured arrangement is a list that is displayed in a specific region of the shared UI. Inclusion of content items in the list makes it easier for users to locate and interact with those content items throughout the communication session. The ability to create and manipulate the list may be limited to only certain users such as a moderator. Use of this list can promote inclusivity and fairness. For instance, inclusion in the list may prevent content items from being forgotten or ignored. Additionally, the names of users who contributed the content items may be shown in the list thereby providing recognition for those users.

SYSTEM AND METHOD FOR MANAGING BEHAVIOR CHANGE APPLICATIONS FOR MOBILE USERS

An example system and method for managing behavior change applications for mobile users is disclosed. In an embodiment of the system and method, data on a plurality of users in a behavioral change program is received from a plurality of devices operating in a communications network. The data is used to determine plurality of user segments. Each user of the plurality of users is classified into a one of the plurality of user segments. Then a plurality of behavioral models is determined, where each of the plurality of behavioral models comprises a statistical model of relations between behaviors of users within a corresponding one of the plurality of user segments. An intervention model is then determined for a user, where the intervention model is based on a behavior model of the user segment to which the user belongs. Interventions are then sent to a device of the user according to the intervention model. 1. A method of managing behavior change applications in a communications network comprising:receiving data on a plurality of users in a behavioral change program, the data received from a plurality of devices operating in the communications network;determining a plurality of user segments for the behavioral change program based on the received data; and,determining a plurality of behavioral models, each of the plurality of behavioral models comprising a statistical model of relations between behaviors of users within a corresponding one of the plurality of user segments.2. The method of claim 1 , further comprising;classifying a selected user of the plurality of users into a selected one of the plurality of user segments;determining an intervention model for the selected user based on a behavior model of the selected one of the plurality of user segments; and,sending interventions to a device of the selected user according to the intervention model.3. The method of claim 2 , wherein the receiving data on a plurality of users comprises:receiving data on activities ...

SYSTEM AND METHOD FOR MANAGING BEHAVIOR CHANGE APPLICATIONS FOR MOBILE USERS

An example system and method for managing behavior change applications for mobile users is disclosed. In an embodiment of the system and method, data on a plurality of users in a behavioral change program is received from a plurality of devices operating in a communications network. The data is used to determine plurality of user segments. Each user of the plurality of users is classified into a one of the plurality of user segments. Then a plurality of behavioral models is determined, where each of the plurality of behavioral models comprises a statistical model of relations between behaviors of users within a corresponding one of the plurality of user segments. An intervention model is then determined for a user, where the intervention model is based on a behavior model of the user segment to which the user belongs. Interventions are then sent to a device of the user according to the intervention model. 1. A system for managing behavior change applications receiving data associated with a plurality of users operating a plurality of devices in a communications network and delivering interventions to the plurality of users , the system comprising: receive a first data set from a plurality of applications, each of the plurality of applications implemented on one of the plurality of devices and collecting data associated with one of the plurality of users for the first data set, wherein the first data set includes information on user attributes of the plurality of users;', 'determine a plurality of user segments for a behavioral change program based on the first data set, the plurality of user segments each including a subset of the plurality of first users;', 'determine a second data set, the second data set being a subset of the first data set and associated with a selected user segment of the plurality of user segments;', 'determine an intervention model, the intervention model based on the second data set and associated with the selected user segment;', 'receive a ...

Therapeutic Regimen for Hypertension

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension. 1. (canceled)44. (canceled)54. (canceled)67. A method according to wherein the fourteen single nucleotide polymorphisms are determined sequentially or simultaneously.68. A method according to wherein the single nucleotide polymorphisms are determined simultaneously.69. A method according to wherein the patient's genotype of procedures c claim 66 , d claim 66 , e and f does not have the homozygous single nucleotide sequences of procedures a and b.70. A method according to wherein the polymerase amplification comprises a first step of a PCR amplification using PCR primers corresponding to portions of the fourteen snp's and a second step of an SNE extension using SNE primers and all four nucleotide terminators with the SNE primers corresponding to portions of the fourteen snps extending from the variable nucleotide toward the 5′ end claim 66 , to produce fourteen SNE extended sequences with each SNE extended sequence having as its 3′ terminus the variable nucleotide of the corresponding snp.71. A method according to wherein the fourteen single nucleotide polymorphisms are determined sequentially or simultaneously.72. A method according to wherein the fourteen single nucleotide polymorphisms are determined simultaneously.73. A kit for use in the method of comprising as a first component PCR primer pairs corresponding to both variations of the fourteen single nucleotide polymorphisms claim 70 , as a second component SNE primers corresponding to 5′ portions of the fourteen polymorphisms but not including the variable nucleotides claim 70 , and as a third component the four nucleotide terminators.74. A kit according to wherein the PCR primers have nucleotide sequence fragments corresponding to both polymorph variations of the fourteen single nucleotide polymorphic sequences.75. A kit according to wherein ...

Previews of Electronic Notes

Embodiments include notes application features including notes page preview and other features, but the embodiments are not so limited. In an embodiment, a computer-based method can be configured to generate a notes page preview based on a source notes page, wherein the notes page preview includes one or more of a title, a thumbnail, and/or a snippet generated from the source notes page. A handheld device of an embodiment includes a notes application interface configured in part to display and dynamically update one or more notes page previews, wherein each notes page preview includes a plurality of preview display areas including a title display area, a thumbnail display area, and/or a snippet display area. Other embodiments are included. 1. A method comprising:generating population information for a notes page preview associated with a source notes page of a collection of notes pages, the notes page preview having a number of preview display portions including a title display portion to display a title generated from the source notes page, a thumbnail display portion to display a thumbnail generated from the source notes page, and a snippet display portion to display a snippet generated from the source notes page; andstoring the population information for use in displaying one or more notes page previews.2. The method of claim 1 , further comprising dynamically updating one or more of the preview display portions based on changes made to a corresponding source notes page.3. The method of claim 2 , further comprising populating a location display portion of the notes page preview with a notebook location of the source notes page.4. The method of claim 1 , further comprising displaying notes page previews in a list claim 1 , wherein one or more of the notes page previews are grouped together according to a group type.5. The method of claim 1 , further comprising using a thumbnail population heuristic to generate a thumbnail from the source notes page to be displayed ...

EDITABLE WHITEBOARD TIMELINE

Systems and methods for recording and archiving whiteboard sessions associated with an electronic whiteboard are provided. In aspects, archived whiteboard sessions may be assigned to bookmarks along a whiteboard timeline, which may be editable. For instance, one or more ink strokes associate with an archived whiteboard session may be edited, i.e., added, deleted and/or altered in any way. Moreover, a bookmark corresponding to an archived whiteboard session may be renamed and/or relocated along the whiteboard timeline. In this way, whiteboard sessions may be updated or augmented for future use, may be organized in any suitable order along the whiteboard timeline (e.g., regardless of chronology), and may be named according to descriptive titles or topics (e.g., as opposed to automated date-stamping based on receipt date). In this way, an editable timeline associated with an electronic whiteboard may provide an organized library of readily-presentable content. 1. A computer system comprising:at least one processing unit; and receiving a series of ink strokes during a session on an electronic whiteboard;', 'archiving the session including the series of ink strokes to a bookmark on a timeline;', 'receiving a selection of the bookmark;', 'receiving an edit to the archived session; and', 'storing the edited session., 'at least one memory storing computer executable instructions that, when executed by the at least one processing unit, cause the computer system to perform a method, the method comprising2. The computer system of claim 1 , further comprising:in response to the selection of the bookmark, entering an edit mode.3. The computer system of claim 1 , wherein the edit to the archived session comprises one or more of:a change to an ink stroke of the series of ink strokes;a deletion of an ink stroke of the series of ink strokes; andan addition of an ink stroke to the series of ink strokes.4. The computer system of claim 3 , wherein the change to an ink stroke comprises ...

MACHINE ASSAY AND ANALYSIS FOR SELECTING ANTIHYPERTENSIVE DRUGS

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension. 1. A method comprising:obtaining a test sample from a subject suspected of having high blood pressure;performing at least one assay to determine single nucleotide polymorphisms (SNPs) within the test sample;assigning weighting values to SNPs detected within the test sample; andexecuting a mathematical algorithm based on the weighting values to provide a treatment recommendation.2. The method of claim 1 , wherein the weighting values are assigned based on the number and results of medical studies on the effects of the corresponding SNPs.3. The method of claim 1 , wherein the SNPs are provided as an assessment of genetic variants in one of a cardiac system claim 1 , a vascular system claim 1 , and a renal system of the subject.4. The method of claim 2 , wherein each SNP is given a score for functionality claim 2 , and wherein a functional genotype is one that has demonstrated enhanced receptor function claim 2 , altered drug metabolism claim 2 , greater protein expression claim 2 , or higher channel activity claim 2 , depending on the genotype.5. The method of claim 4 , wherein the weighting value is assigned based on the degree to which studies are in agreement concerning functionality of an SNP.6. The method of claim 1 , further comprising generating a recommendation score based on the degree of homozygosity versus heterozygosity of the subject for a given functional genotype.7. The method of claim 6 , further comprising: assessing which organ system claim 6 , of at least a cardiac system claim 6 , a renal system and a vascular system is most functional and will lead to a highest degree of drug response.8. A non-transitory computer-readable medium including instructions that claim 6 , when executed on a processor claim 6 , cause the processor to:obtain a test sample from a subject suspected of having ...

MECHANICAL VENTILATION BASED ON ALVEOLAR VENTILATION

The present disclosure pertains to a mechanical ventilator system configured to control a pressurized flow of breathable gas for delivery to a subject based on alveolar ventilation of the subject. The mechanical ventilator system comprises a pressure generator configured to generate the pressurized flow of breathable gas for delivery to the subject, the pressure generator configured to control one or more ventilation parameters of the pressurized flow of breathable gas according to a prescribed mechanical ventilation therapy regime; one or more sensors configured to generate output signals conveying information related to the alveolar ventilation of the subject; and one or more hardware processors configured by machine-readable instructions to: determine the alveolar ventilation of the subject based on the output signals; and cause the pressure generator to adjust the one or more ventilation parameters of the pressurized flow of breathable gas based on the determined alveolar ventilation. 1. A mechanical ventilator system configured to control a pressurized flow of breathable gas for delivery to a subject based on alveolar ventilation of the subject , the mechanical ventilator system comprising:a pressure generator configured to generate the pressurized flow of breathable gas for delivery to the subject, the pressure generator configured to control one or more ventilation parameters of the pressurized flow of breathable gas according to a prescribed mechanical ventilation therapy regime;one or more sensors configured to generate output signals conveying information related to the alveolar ventilation of the subject; and determine the alveolar ventilation of the subject based on the output signals; and', 'cause the pressure generator to adjust the one or more ventilation parameters of the pressurized flow of breathable gas based on the determined alveolar ventilation., 'one or more hardware processors configured by machine-readable instructions to2. The system of ...

DYNAMICALLY INTEGRATED NAVIGATION TESTER

An Inertial Navigation System (INS) testing system includes a Unit Under Test (UUT) with an INS module, a DAT tool configured to provide command and control functions to a user, and a Dynamically Integrated Navigation Tester (DINT) in communication with the UUT and the DAT tool. The DINT includes a truth data conversion module configured to receive truth data and convert it to navigation data suitable for transmission to the UUT. The INS testing system advantageously allow a user to interface with a UUT while providing user-specified dynamic inputs from the DINT with the truth data selected by the user. 1. An Inertial Navigation System (INS) testing system comprising:a Unit Under Test (UUT) comprising an INS module;a DAT tool configured to provide command and control functions to a user; anda Dynamically Integrated Navigation Tester (DINT) in communication with the UUT and the DAT tool, the DINT comprising a truth data conversion module and a synchronization module,wherein the truth data conversion module is configured to receive truth data and convert it to navigation data suitable for transmission to the UUT.2. The INS testing system of claim 1 , further comprising a satellite simulator in communication with the UUT and the DINT.3. The INS testing system of claim 1 , further comprising a real-time GPS data source in communication with the UUT and the DINT.4. The INS testing system of claim 3 , wherein the real-time GPS data source comprises an Embedded GPS/IMU (EGI) or an Attitude Heading Reference System (AHRS).5. The INS testing system of claim 1 , wherein the UUT further comprises a GPS.6. The INS testing system of claim 1 , wherein the DINT further comprises an interface for receiving truth data from an external memory device.7. The INS testing system of claim 1 , wherein the DINT comprises a modified version of the UUT.8. The INS testing system of claim 1 , wherein inertial data is provided by the UUT.9. A Dynamically Integrated Navigation Tester (DINT) ...

CALLING ATTENTION TO A SECTION OF SHARED DATA

Technologies are disclosed that enable a computing system to provide a computationally efficient interface for collaborative viewing and/or editing of shared content. Individual users may separately edit (e.g., create, modify, etc.) content in a particular section (e.g., area, region, page, etc.) of a shared data unit such as a file. A result of this separate editing may cause sections of the shared data unit to be off-screen from a perspective of a user and/or a computing device being used by the user. The disclosed techniques provide an effective way for an individual user, of a multi-user sharing session, to request that other users view content being edited by the individual user in a section that is “off-screen” for the other users. Based on the request, a selectable user interface element can be displayed enabling efficient access to the content to be viewed by the other users. 1. A system comprising:one or more processors; and cause first content of a first section of shared data to be displayed on a display screen of a first computing device associated with a first user, wherein the shared data is accessible to a plurality of users in a multi-user sharing session;', 'cause second content of a second section of the shared data to be displayed on a display screen of a second computing device associated with a second user, wherein the second content of the second section is different than the first content of the first section;', 'cause a user interface element that represents the first user to be displayed on the display screen of the second computing device;', 'receive, from the first computing device, a request for the second user to view the first section, the request being received based on a selection, by the first user, identifying the second user from the plurality of users in the multi-user sharing session;', 'alter a visual appearance of the user interface element that represents the first user, based at least in part on the request, to indicate that ...

CHILD RESISTANT ZIPPER CLOSURE SYSTEM AND ROCKABLE SLIDER DEVICE AND METHODS

A slider for a zipper closure includes a separator plow that is positionable between interlocking tracks of the zipper closure to open the zipper closure by pivoting an opening end of the slider in a direction toward a notch to position the plow between the interlocking closures. The slider can be disengaged by pivoting the slider so that the plow is outside of the interlocking tracks. 1. A slider for a zipper closure having interlocking members with complementary profiles for interlocking and unlocking; the slider comprising:(a) an opposite opening end and closing end;(b) a top member;(c) a pair of spaced legs depending from the top member; the spaced legs defining an open volume therebetween to allow for passage of the tracks therethrough and with the legs straddling the tracks;(d) internal surfaces spaced sufficiently close together in a vicinity of the closing end to press the profiles into interlocking relationship as the slider is moved in a closing direction along the zipper closure;(e) a separator plow extending from the opening end; the separator plow being selectively moveable into a position to be between the interlocking members and separate the interlocking profiles as the slider is moved in an opening direction along the zipper closure by pivoting the opening end of the slider in a direction toward the profiles;.(f) a protrusion in the vicinity of the opening end extending from at least one of the legs into the open volume toward the opposite leg; and(g) wherein at least one leg has a first track-accommodating groove and a second track-accommodating groove; the first and second track-accommodating grooves being separated by the protrusion.2. The slider of wherein the first track-accommodating groove and second track-accommodating groove are angled relative to each other at an angle greater than 0° and less than 90°.3. The slider of wherein the first track-accommodating groove and second track-accommodating groove are angled relative to each other at an ...

Power-controlled bonding of resin or (co)polymer powder and flake materials

The present invention provides methods of making sticky powder comprising mixing one or more resin or (co)polymer powders in one or more mixing devices without agglomerating the powders and while measuring the power, work or torque drawn by the mixing devices, the mixing continuing until the measure of the power or torque drawn indicates that the powders have become sticky. The mixing further comprises adding to the powders one or more dry materials and mixing to so that the dry materials adhere or “bond” to the sticky powders. Alternatively, the methods further comprise slowing or stopping the mixing, or cooling while mixing once the said sticky powders have been formed, adding one or more dry materials to form a sticky powder mixture, and further mixing to bond the sticky powders and the dry materials together. The dry materials may comprise one or more flake materials, e.g. metallic flakes; layered pigments, clays, catalysts or antimicrobials; resins or (co)polymers; cyroprocessed materials, and materials encapsulated or dispersed in brittle materials. The methods may be automated.

Connection systems and methods thereof for establishing electrical connections across a sterile field

Disclosed herein are connection systems for establishing electrical connections across a sterile field. An example connection system includes a sensor connector, a probe connector, and a tether having a first end connected to the sensor connector and a second end connected to the probe connector. The sensor connector includes a piercing element. The piercing element is configured to pierce a sterile side of a drape and establish a first electrical connection with a receptacle of a sensor when the piercing element is inserted into the receptacle. The probe connector includes a probe-connecting means configured for a user to establish a second electrical connection between an electrical contact of the probe connector and a wire probe. The tether is configured to convey electrical signals between the sensor connector and the probe connector. Also disclosed herein are methods of connection systems for establishing electrical connections across a sterile field.

Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid A (3D-MLA)

Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-0-deacylated monophosphoryl lipid A (3D-MLA) having at least about 20 mol% of the hexaacyl congener group. Also herein is disclosed a method of extracting lipopolysaccharide (LPS) from a culture of deep rough mutant bacterial strain cells, comprising: (a) extracting the cells with a solution consisting essentially of at least about 75 wt% of an aliphatic alcohol having from 1 to 4 carbon atoms and the balance water, thereby producing cells with reduced phospholipid content; and (b) extracting the cells with reduced phospholipid content with a solution comprising chloroform and methanol, thereby yielding a solution of LPS in chloroform and methanol (mM). This method provides LPS solutions in CM that have reduced phospholipid content and are produced by relatively simple and inexpensive process steps.

Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid A (3D-MLA)

Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-0-deacylated monophosphoryl lipid A (3D-MLA) having at least about 20 mol% of the hexaacyl congener group. Also herein is disclosed a method of extracting lipopolysaccharide (LPS) from a culture of deep rough mutant bacterial strain cells, comprising: (a) extracting the cells with a solution consisting essentially of at least about 75 wt% of an aliphatic alcohol having from 1 to 4 carbon atoms and the balance water, thereby producing cells with reduced phospholipid content; and (b) extracting the cells with reduced phospholipid content with a solution comprising chloroform and methanol, thereby yielding a solution of LPS in chloroform and methanol (mM). This method provides LPS solutions in CM that have reduced phospholipid content and are produced by relatively simple and inexpensive process steps.

Methods for the production of 3-O-deactivated-4′-monophosphoryl lipid A (3D-MLA)

The invention relates to a method for extracting lipopolysaccharide (LPS) from rough trough mutant bacteria cells by extracting the cells with an aqueous aliphatic alcohol having from 1 to 4 carbon atoms at a temperature between 35 and 65 degrees C. to produce cells having a reduced phospholipid content. The resultant cells are then extracted with chloroform/methanol to yield LPS.

Low Profile Access Port

Un puerto de acceso de bajo perfil para la colocación subcutánea en un paciente, que comprende: un cuerpo (12) que incluye: un conducto (18) que incluye un puerto de entrada (16) en un extremo proximal del mismo; y una copa de recepción (14) en comunicación con el puerto de entrada (16), la copa de recepción (14) con forma cóncava para dirigir una aguja portadora de catéter al interior del conducto (18) a través del puerto de entrada (16), la copa de recepción para ser orientada sustancialmente hacia la superficie de la piel cuando está implantada subcutáneamente dentro del paciente; un conjunto de válvula/junta (22) dispuesto en el conducto (18) que permite el paso del catéter a través del mismo; caracterizado por que la copa de recepción además incluye una ranura de guía (28) para dirigir e incidir la punta distal de la aguja portadora de catéter en dirección al puerto de entrada (16).

A process to avoid inhibition of acetogens by co

A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 µM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 µM or less.

Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid A (3D-MLA)

An energy harvester for converting vibrational motion of a vibrating equipment into electrical energy, and a device for monitoring the operation of a vibrating equipment

The invention relates to an energy harvester (1) for converting vibrational motion of a vibrating equipment (2) into electrical energy. The energy harvester (1) comprises a pendulum (3) arranged to be pivotably attached to said vibrating equipment (2), a motion limiter (4) arranged to limit a pivoting motion of said pendulum (3), and a generator (5) connected to said pendulum (3) and arranged to convert said pivoting motion into electrical energy. The vibrational motion has an operating frequency, and said pendulum (3) has a natural frequency different from said operating frequency. The invention also relates to a device (17) for monitoring the operation of a vibrating equipment (2).

Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-O-deacylated monophosphoryl lipid A (3D-MLA) having at least abo ut 20 mol% of the hexaacyl congener group. Also herein is disclosed a method of extracting lipopolysaccharide (LPS) from a culture of deep rough mutant bacterial strain cells, comprising: (a) extracting the cells with a solution consisting essentially of at least about 75 wt% of an aliphatic alcohol havi ng from 1 to 4 carbon atoms and the balance water, thereby producing cells with reduced phospholipid content; and (b) extracting the cells with reduced phospholipid content with a solution comprising chloroform and methanol, thereby yielding a solution of LPS in chloroform and methanol (CM). This method provides LPS solutions in CM that have reduced phospholipid content a nd are produced by relatively simple and inexpensive process steps.

Improved therapeutic regimen for hypertension

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension.

A process to avoid inhibition of acetogens by co

A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 µM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 µM or less.

Low-profile access port

A low-profile access port for subcutaneous implantation within the body of a patient is disclosed. The access port includes a receiving cup that provides a relatively large subcutaneous target to enable a catheter-bearing needle to access the port without difficulty. In addition, the access port includes a valve/seal assembly to permit pressurized fluid injection through the port while preventing backflow. In one embodiment, therefore, a low- profile access port comprises a body including a conduit with an inlet port at a proximal end thereof, and a receiving cup. The receiving cup is concavely shaped to direct a catheter- bearing needle into the conduit via the inlet port. The receiving cup is oriented substantially toward a skin surface when subcutaneously implanted within the patient to ease needle impingement thereon. A valve/seal assembly disposed in the conduit enables passage of the catheter therethrough while preventing fluid backflow.

Advanced cavity receivers for parabolic solar troughs

A heat-absorbing element partly enclosed in an insulating layer or jacket, has absorbing surface that is accessible to solar radiation. The thermal insulation is designed to provide entry to solar radiation by way of a cavity. In cross-section, the insulation jacket has approximately the form of a letter "C" or "U" oriented so that the opening of the "C" or "U" faces toward a parabolic collector that focuses light thereon. The absorbing surface can be substantially planar (i.e., flat) rather than another shape (for example, in one embodiment, an arc) which reduces the absorbing surface's area for a given aperture width. This reduces the area that can re-radiate heat energy away from the heat absorbing element. The heat absorbing element is supported so that its distance relative to the parabolic collector does not change as the heat absorbing element expands upon heating and contracts upon cooling.

Methods for the production of 3-0-deactivated-4'-monophosphoryl lipid a (3d-mla)

Airborne alerting system

Child-resistant zipper closure system and rockable slider device and methods

【課題】従来技術を改良する、対小児安全スライダおよびクロージャシステムを提供する。【解決手段】ジッパクロージャ用のスライダは、セパレータプラウを含み、このセパレータプラウは、プラウを連結クロージャ間に位置決めするようにスライダの開口端部を切欠きに向かう方向に枢動させることによって、ジッパクロージャを開口するようにジッパクロージャの連結トラック間に位置決め可能である。スライダは、プラウが連結トラックの外側にあるように、スライダを枢動させることによって脱係合することができる。【選択図】図５

A process to avoid inhibition of acetogens by co

Miniature high performance solenoid valve

A solenoid valve assembly (10) includes an armature (34) having a longitudinal axis (Y) and an ovular cross-section, the armature being moveable along the longitudinal axis from a first position to a second position, and a bobbin including a solenoid coil (36) configured to electromagnetically move the armature when energised. The bobbin defines a recess (62) also having an ovular cross section for receiving the armature and restricting lateral movement of the armature, thereby providing a linear actuation path for the armature along the longitudinal axis. A flux coupler (38) and a flux bracket (40) form a magnetic circuit with the bobbin to electromagnetically move the armature. The flux bracket has a pole piece (42) with a commensurate ovular cross-section that limits the movement of the armature along the longitudinal axis, thereby determining a stroke length of the armature. During manufacture, the flux bracket, and therefore the pole piece, are moved relative to the flux coupler to set the stroke length.

Electrical connector module for a high density electrical connector

This invention relates to the field of high density connectors for connecting circuit board edges to other connectors. A modular design is provided which has modules that fit into a frame to form the connector. Each module consists of a housing having a base and a cover which receives the circuit card edge. The cover is designed to insulate between adjacent contacts and to maintain contact tail spacing. This cover also eliminates the need for additional potting material between contact tails and reduces the overall height of the connector.

Previews of electronic notes

Embodiments include notes application features including notes page preview and other features, but the embodiments are not so limited. In an embodiment, a computer-based method can be configured to generate a notes page preview based on a source notes page, wherein the notes page preview includes one or more of a title, a thumbnail, and/or a snippet generated from the source notes page. A handheld device of an embodiment includes a notes application interface configured in part to display and dynamically update one or more notes page previews, wherein each notes page preview includes a plurality of preview display areas including a title display area, a thumbnail display area, and/or a snippet display area. Other embodiments are included.

Production procedures of 4'-monophosphoryl lipid A 3-O-deacylated (3D-MLA)

Un procedimiento de producción de una composición de lipopolisacárido (LPS) que comprende: (a) Cultivar un cultivo de una cepa bacteriana mutante rugosa profunda en un medio; (b) Mantener el cultivo en fase estacionaria durante al menos 5 h; (c) Recoger células del cultivo; y (d) Extraer LPS de las células A method of producing a lipopolysaccharide (LPS) composition comprising: (a) Cultivating a culture of a deep rough mutant bacterial strain in a medium; (b) Maintain the stationary phase culture for at least 5 h; (c) Collect cells from the culture; and (d) Extract LPS from cells

Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid A (3D-MLA)

Calling attention to a section of shared data

Technologies are disclosed that enable a computing system to provide a computationally efficient interface for collaborative viewing and/or editing of shared content. Individual users may separately edit (e.g., create, modify, etc.) content in a particular section (e.g., area, region, page, etc.) of a shared data unit such as a file. A result of this separate editing may cause sections of the shared data unit to be off-screen from a perspective of a user and/or a computing device being used by the user. The disclosed techniques provide an effective way for an individual user, of a multi-user sharing session, to request that other users view content being edited by the individual user in a section that is "off-screen" for the other users. Based on the request, a selectable user interface element can be displayed enabling efficient access to the content to be viewed by the other users.

Systems and methods to incorporate master navigation system resets during transfer alignment

Systems and methods to incorporate master navigation system resets during transfer alignment are provided. In one embodiment, a system comprises: a set of local inertial sensors; a local navigation processor coupled to local inertial sensors, the local navigation processor receiving inertial navigation data from local inertial sensors and converting the data into a navigation solution; a local Kalman filter (LKF) coupled to the local navigation processor and a master Kalman filter (MKF), the LKF receiving the navigation solution. The LKF receives from the MKF a Precision Transfer Alignment Message (PTAM) that includes at least one navigation aid measurement. The LKF inputs the navigation aid measurement into a measurement formation algorithm and calculates a measurement residual. The LKF receives from the MKF a Reset Transfer Alignment Message (RTAM) that includes a bias correction. The LKF inputs the bias correction into a state propagation algorithm to add to a navigation state.

Airborne alerting system

Systems, methods and protocol for assuring separation of aircraft during parallel approaches. The systems, methods and protocol function in cooperation with existing TCAS to facilitate approaches of multiple aircraft on closely-spaced parallel runways. The systems, methods and protocol utilize data transmissions from equipped aircraft to obtain tracking information which is used in separation algorithms to generate alerts to an observer of possible threats. The systems, methods and protocol facilitate parallel approaches to closely-spaced parallel runways under Instrument Approach Procedure.

Method and navigation system for initialization with inertial data compensation

Process to control CO concentrations in fermentations

A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

Synthesis of sulfamidates

A regio- and stereoselective two-stage synthesis of β-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this approach is underscored by the considerable number and variety of substrates which display high levels of selectivity in the process. As such, this method provides facile access to compounds for use in myriad applications, whether as chiral ligands to perform asymmetric synthesis or as molecular probes to explore problems in chemical biology.

Smoothed navigation solution using filtered resets

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Mirror collector for parabolic solar trough

A concentrated solar power system that is actuated to track a solar light source. A plurality of curved mirrors for a solar energy collector each having a mirrored surface, a curvature, and a support system that maintains the desired curvature under gravitational and wind loading conditions. In various configurations, the mirror is supported by support structures constructed with support masts and cable arrangements. The support structures are designed to be less expensive than conventional support structures by use of less material and by employing simplified manufacturing methods. The plurality of curved mirrors can track the solar light source individually or in multiple numbers (e.g., synchronously).

Methods for the production of 3-o-deactivated-4-monophosphoryl lipid a (3d-mla) 3-o--4- a(3d-mla)

Generating and adapting an agenda for a communication session

Technologies are disclosed that enable a computing system to adapt an agenda for a communication session so the agenda more accurately reflects the actual course of discussion during the communication session. A graphical user interface is configured to display aspects of the agenda so that participants of the communication session are aware of topics being discussed or to be discussed, as well as the time initially assigned to discuss the topics. The agenda can adapt depending on the course of discussion during the communication session. That is, agenda items can be removed, reordered, added, extended, shortened, etc. based on an analysis of actual topics being discussed during the communication session and the timing of such discussions. The agenda can additionally or alternatively encourage participation and inclusivity. For instance, the agenda can inform participants of behavior-related goals associated with participation and inclusivity.

Automated retail system control and method

Provided is a system and method for controlling a plurality of automated retail systems, comprising a controller in communication with a plurality of automated retail systems, wherein the controller is configured to receive real-time information from the automated retail systems in order to determine routing, queueing, and production of order messages.

Controlling disclosure of identities in communication sessions

Technologies are disclosed for a computing system that allows users to control the disclosure of their identities during communication sessions. Users can control the disclosure of their identities with respect to certain types of shared content. In one mode of operation, a user can share content anonymously. In another mode of operation, identity may be revealed when certain conditions are met or revealed to only certain other users. For example, the identity of a user who shared a comment anonymously may be revealed if multiple other users agree with that comment. In another mode of operation, the user's identity is revealed to all other users such as in a live video stream. The computing system can control display of users' identities based on user instructions or based on triggering conditions. A user interface (UI) can show content items that identify a user together with content items that are shared anonymously.

Controlling disclosure of identities in communication sessions

Technologies are disclosed for a computing system that allows users to control the disclosure of their identities during communication sessions. Users can control the disclosure of their identities with respect to certain types of shared content. In one mode of operation, a user can share content anonymously. In another mode of operation, identity may be revealed when certain conditions are met or revealed to only certain other users. For example, the identity of a user who shared a comment anonymously may be revealed if multiple other users agree with that comment. In another mode of operation, the user's identity is revealed to all other users such as in a live video stream. The computing system can control display of users' identities based on user instructions or based on triggering conditions. A user interface (UI) can show content items that identify a user together with content items that are shared anonymously.

Kollisionswarnsystem für flugzeuge

Synthesis of resveratrol-based compounds

A compound having the structure: bond α is present or absent, wherein when bond α is absent, then R 1 is =0 or S(CH 2 ) 1-3 -phenyl and when bond α is present, then R 1 is H, wherein the phenyl is substituted or unsubstituted; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are independently H or OR 11 wherein each occurrence of R 11 is independently H, methyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, phosphate, sulfate, sulfonic ester, or ester; when α is absent and R 1 is =0, then R 10 is other than OH; and when α is absent and R 1 is S(CH 2 ) 1-3 -phenyl, then R 10 is other thanOCH 3 , or a salt thereof.

Genetic method for diagnosis and treatment of pre and post coronavirus infections

The present invention is directed to management of coronavirus exposure and/or infection by analyzing a patients 21 SNPs of the patients AGT, renin, AT1R, ACE, ADRB1 and ACE2 genes arnd use of the analysis to determine which pharmaceutical compound(s) associated with treatment of the RAAS system issues should be administered and/or discontinued, if any, to ameliorate the potential for coronavirus infection and/or the severity of coronavirus infection. Typical coronaviruses to be treated include SARS coronavirus, MERS coronavirus and/or Covid-19 coronavirus. Co-administration of anti-viral, quinoline-like and/or quinone-like drugs and ACE2 agonists are also disclosed.

Viscoelastic foam

Recovery time and/or airflow of flexible polyurethane foam is increased by including certain tackifiers in the foam formulation. The tackifiers are characterized in being incompatible with polyol or polyol mixture used to make the foam, having a viscosity of at least 10,000 centipoise at 25°C, having a glass transition temperature of at most 15°C and being inert to other components of the foam formulation.

Método para produzir uma espuma flexível de poliuretano, espuma de poliuretano e espuma flexível de poliuretano

O tempo de recuperação e/ou fluxo de ar da espuma flexível de poliuretano é aumentado incluindo determinados acentuadores de pegajosidade na formulação da espuma. Os acentuadores de pegajosidade são caracterizados por serem incompatíveis com o poliol ou a mistura de poliol usada para produzir a espuma, tendo uma viscosidade de pelo menos 10 Pa^s (10.000 centipoises) a 25 °C, tendo uma temperatura de transição vítrea de no máximo 15 °C e sendo inerte aos outros componentes da formulação da espuma.

Synthesis of sulfamidates

A regio- and stereoselective two-stage synthesis of β-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this approach is underscored by the considerable number and variety of substrates which display high levels of selectivity in the process. As such, this method provides facile access to compounds for use in myriad applications, whether as chiral ligands to perform asymmetric synthesis or as molecular probes to explore problems in chemical biology.

Machine assay and analysis for selecting antihypertensive drugs

The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension.

Earphone for sound reproduction

In an aspect of the invention, a sealed earphone is provided with a nozzle (40), the earphone configured to be positioned in a user's ear so that the nozzle extends toward the ear canal of the user. The earphone includes a driver (30) mounted within a housing (10) of the earphone, the driver including a sound port (35) acoustically sealed to the nozzle. In an embodiment, the driver may include an acoustic port that directs sound into an acoustic enclosure so as to modify the frequency response of the earphone. The earphone may include a fastener that removably mounts the nozzle to the housing so that the nozzle may be readily removed and cleaned or replaced.

Genetic method for diagnosis and treatment of pre and post coronavirus infections

Controlling disclosure of identities in communication sessions

Technologies are disclosed for a computing system that allows users to control the disclosure of their identities during communication sessions. Users can control the disclosure of their identities with respect to certain types of shared content. In one mode of operation, a user can share content anonymously. In another mode of operation, identity may be revealed when certain conditions are met or revealed to only certain other users. For example, the identity of a user who shared a comment anonymously may be revealed if multiple other users agree with that comment. In another mode of operation, the user's identity is revealed to all other users such as in a live video stream. The computing system can control display of users' identities based on user instructions or based on triggering conditions. A user interface (UI) can show content items that identify a user together with content items that are shared anonymously.

Catheter device having bendable extension legs

Catheter devices can have bendable extension legs. The extension legs may be designed to include armature wire that enables the extension legs to be bent into and to retain a variety of orientations. As a result, a clinician can easily position the luers of the extension legs into positions that are suitable for a particular patient and/or the clinician.

Structured arrangements for tracking content items on a shared user interface

Technologies are disclosed that enable a computing system to present a structured arrangement for tracking content items on a shared user interface (UI) during a communication session. The structured arrangement is a list that is displayed in a specific region of the shared UI. Inclusion of content items in the list makes it easier for users to locate and interact with those content items throughout the communication session. The ability to create and manipulate the list may be limited to only certain users such as a moderator. Use of this list can promote inclusivity and fairness. For instance, inclusion in the list may prevent content items from being forgotten or ignored. Additionally, the names of users who contributed the content items may be shown in the list thereby providing recognition for those users.

Structured arrangements for tracking content items on a shared user interface

Technologies are disclosed that enable a computing system to present a structured arrangement for tracking content items on a shared user interface (UI) during a communication session. The structured arrangement is a list that is displayed in a specific region of the shared UI. Inclusion of content items in the list makes it easier for users to locate and interact with those content items throughout the communication session. The ability to create and manipulate the list may be limited to only certain users such as a moderator. Use of this list can promote inclusivity and fairness. For instance, inclusion in the list may prevent content items from being forgotten or ignored. Additionally, the names of users who contributed the content items may be shown in the list thereby providing recognition for those users.

Structured arrangements for tracking content items on a shared user interface

Technologies are disclosed that enable a computing system to present a structured arrangement for tracking content items on a shared user interface (UI) during a communication session. The structured arrangement is a list that is displayed in a specific region of the shared UI. Inclusion of content items in the list makes it easier for users to locate and interact with those content items throughout the communication session. The ability to create and manipulate the list may be limited to only certain users such as a moderator. Use of this list can promote inclusivity and fairness. For instance, inclusion in the list may prevent content items from being forgotten or ignored. Additionally, the names of users who contributed the content items may be shown in the list thereby providing recognition for those users.

Controlling disclosure of identities in communication sessions

Technologies are disclosed for a computing system that allows users to control the disclosure of their identities during communication sessions. Users can control the disclosure of their identities with respect to certain types of shared content. In one mode of operation, a user can share content anonymously. In another mode of operation, identity may be revealed when certain conditions are met or revealed to only certain other users. For example, the identity of a user who shared a comment anonymously may be revealed if multiple other users agree with that comment. In another mode of operation, the user's identity is revealed to all other users such as in a live video stream. The computing system can control display of users' identities based on user instructions or based on triggering conditions. A user interface (UI) can show content items that identify a user together with content items that are shared anonymously.

Synthesis of resveratrol-based compounds

A compound having the structure: bond α is present or absent, wherein when bond α is absent, then R 1 is =0 or S(CH 2 ) 1-3 -phenyl and when bond α is present, then R 1 is H, wherein the phenyl is substituted or unsubstituted; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are independently H or OR 11 wherein each occurrence of R 11 is independently H, methyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, phosphate, sulfate, sulfonic ester, or ester; when α is absent and R 1 is =0, then R 10 is other than OH; and when α is absent and R 1 is S(CH 2 ) 1-3 -phenyl, then R 10 is other thanOCH 3 , or a salt thereof.