27-07-2001 дата публикации
Номер: NZ335892A
A compound of the Formula (IA) are gram-positive antibacterial agents useful for the treatment of diseases caused by methicillin-resistant Staphylococcus aureus. Wherein; X is halogen; Y is hydrogen or halogen; A is CO2H, PO3H2, SO3H or tetrazolyl; L1 is a furylene group, a thienylene group, a C2-10alkylene group, or a C2-10alkylene group interrupted by one or more groups independently selected from vinyl, S, SO, SO2, SO2NH, Formula (II) or Formula (III); n is 0 or 1; R3 and R4 are each independently selected from hydrogen or C1-6alkyl; R2 is hydrogen, NH2, pyrrolidinyl, C3-6cycloalkyl, C1-6alkyl, C2-6alkyl substituted by one or more substituents independently selected from OH, NR5R6 in which R5 and R6 are each independently hydrogen or C1-6alkyl, CO2H, morpholinyl, morpholinyl quaternized by a C1-6alkyl group, oxo, halogen, SO3H, PO3H2, imidazolyl, imidazolyl substituted by 1-2 C1-6alkyl groups, tetrazolyl, tetrazolyl substituted by 1-2 C1-6alkyl groups or N=CR7 in which R7 is a furan or thiophene ring optionally substituted by either -CO2H or -SO3H, phenyl or phenyl substituted by 1-3 substituents independently selected from OH, NR5R6, CO2H, morpholinyl, morpholinyl quaternized by C1-6alkyl group, oxo, halogen, SO3H, PO3H2, imidazolyl, imidazolyl substituted by 1-2 C1-6alkyl groups, tetrazolyl, tetrazolyl substituted by 1-2 C1-6alkyl groups or N=CR7; M is hydrogen, a carboxyl-protecting group or a negative charge; XÈ is a counter anion; and M is 0 or an integer selected so as to make the molecule as a whole electrically neutral.
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