MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE AND DIFFERENTIATION

Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed. 1. An implantable medical device comprising a multiple layer coating matrix attached to at least a portion of said medical device , wherein said matrix promotes the capture and growth of endothelial cells or endothelial progenitor in vivo.2. The implantable medical device of claim 1 , wherein the medical device is selected from the group consisting of a stent claim 1 , a stent graft claim 1 , a synthetic vascular graft claim 1 , a heart valve claim 1 , a catheter claim 1 , a vascular prosthetic filter claim 1 , a pacemaker claim 1 , a pacemaker lead claim 1 , a defibrillator claim 1 , a patent foramen oval septal closure device claim 1 , a vascular clip claim 1 , a vascular aneurysm occluder claim 1 , a hemodialysis graft claim 1 , a hemodialysis catheter claim 1 , an atrioventricular shunt claim 1 , an aortic aneurysm graft device claim 1 , a venous valve claim 1 , a suture claim 1 , a vascular anastomosis clip claim 1 , an indwelling venous catheter claim 1 , an indwelling arterial catheter claim 1 , a vascular sheath and a drug delivery port.3. The implantable medical device of claim 1 , wherein the ...

PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis. 1. An implantable medical device having a luminal surface and a coating; wherein the coating comprises one or more layers of a non-polymer matrix; one or more pharmaceutical substances , and a ligand attached to said matrix and configured to capture circulating progenitor cells on the luminal surface of said device after implantation of said medical device into a patient.2. The implantable medical device of claim 1 , wherein the medical device is a stent claim 1 , a vascular graft claim 1 , a synthetic graft claim 1 , a heart valve claim 1 , a catheter claim 1 , a vascular prosthetic filter claim 1 , a pacemaker claim 1 , a pacemaker lead claim 1 , a defibrillator claim 1 , a patent foramen ovate (PFO) septal closure device claim 1 , a vascular clip claim 1 , a vascular aneurysm occluder claim 1 , a hemodialysis graft claim 1 , a hemodialysis catheter claim 1 , an atrioventricular shunt claim 1 , an aortic aneurysm graft device or components claim 1 , a venous valve claim 1 , a sensor claim 1 , a suture claim 1 , a vascular anastomosis clip claim 1 , an indwelling venous or arterial catheter claim 1 , a vascular sheath and a drug delivery port.3. The implantable medical device of claim 1 , wherein ...

Progenitor endothelial cell capturing with a drug eluting implantable medical device

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis. 1. An artificial heart valve , having a coating , wherein the coating comprises a plurality of antibodies , antibody fragments or combinations thereof , wherein the coating further comprises a pharmaceutical substance that inhibits smooth muscle cell migration and/or proliferation , wherein the plurality of antibodies , antibody fragments or combinations thereof specifically bind to a cell surface antigen of endothelial progenitor cells or endothelial cells.2. The artificial heart valve of claim 1 , wherein the cell surface antigen is CD133 claim 1 , CD34 claim 1 , CDw90 claim 1 , CD117 claim 1 , HLA-DR claim 1 , VEGFR-1 claim 1 , VEGFR-2 claim 1 , VEGFR-3 claim 1 , Muc-18 (CD146) claim 1 , Thy-1 claim 1 , Thy-2 claim 1 , CD130 claim 1 , CD30 claim 1 , stem cell antigen (Sca-1) claim 1 , stem cell factor 1 (SCF/c-Kit ligand) claim 1 , Tie-1 claim 1 , Tie-2 claim 1 , VE-cadherin claim 1 , P1H12 claim 1 , TEK claim 1 , CD31 claim 1 , Ang-1 claim 1 , Ang-2 claim 1 , HAD-DR claim 1 , CD45 claim 1 , or E-selectin.3. The artificial heart valve of claim 1 , wherein the plurality of antibodies claim 1 , antibody fragments or combinations thereof are monoclonal.4. The artificial heart valve of claim 1 , wherein the plurality of antibodies claim 1 , antibody fragments or ...

Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis. 1. An implantable medical device having a luminal surface , an abluminal surface and a coating; the coating comprising one or more layers of a matrix; one or more pharmaceutical substances at least on the abluminal surface , and a ligand attached to said matrix and configured to capture circulating progenitor cells on at least the luminal surface of said device after implantation of said medical device into a patient.2. The implantable medical device of claim 1 , wherein the medical device is a stent claim 1 , a vascular graft claim 1 , a synthetic graft claim 1 , a heart valve claim 1 , a catheter claim 1 , a vascular prosthetic filter claim 1 , a pacemaker claim 1 , a pacemaker lead claim 1 , a defibrillator claim 1 , a patent foramen ovale (PFO) septal closure device claim 1 , a vascular clip claim 1 , a vascular aneurysm occluder claim 1 , a hemodialysis graft claim 1 , a hemodialysis catheter claim 1 , an atrioventricular shunt claim 1 , an aortic aneurysm graft device or components claim 1 , a venous valve claim 1 , a sensor claim 1 , a suture claim 1 , a vascular anastomosis clip claim 1 , an indwelling venous or arterial catheter claim 1 , a vascular sheath and a drug delivery port.3. The ...

Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents

A treatment for metallic surfaces and devices having metallic surfaces is described. A film of heptafluorobutylmethacrylate (HFBMA) is applied to a surface by radiofrequency (RF) plasma deposition and subsequently treated with a biologically active agent. A water vapor RF plasma treatment of the HFBMA coating provides reactive groups thereon which can covalently bond to the biologically active agent. Alternatively, a spacer group can be bonded to the activated HFBMA and the biologically active agent can then be bonded to the spacer group. Devices coated according to the invention possess enhanced biocompatibility and the HFBMA coatings are durable even under severe crimping and expansion conditions.

Biocompatible metal surfaces

Metallic surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The surfaces are prepared by a two-step procedure including covalently linking an organosilane having amine reactive sites with the surface of the metallic member, typically through a metal oxide thereof. Thereafter, a biologically active agent is covalently linked to the organosilane coating. The two-step process is particularly advantageous for preparing medical devices in the form of stents which need to be bent and flexed during implantation procedures.

Electro-osmotic infusion catheter

An infusion catheter is provided for delivering treatment fluids including medicaments, drugs, pharmaceuticals, cancer treatment agents and the like directly to a location within a living body such as within a vessel or body cavity. Electro-osmotic infusion is carried out by iontophoretic and/or iontohydrokinesis procedures. The infusion catheter includes both an internal electrode and an integral electrode, both of which are components of or closely associated with a distal portion of the catheter itself. When electrically joined to an EMF source, the electrodes are oppositely charged. The treatment fluid or components of the treatment fluid have an electrical charge which is the same as the internal electrode, as a result of which the medicament moves away from the internal electrode and to the body component being treated.

Medical device with coating for capturing genetically-altered cells and methods for using same

Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.

Medical device with coating that promotes endothelial cell adherence and differentiation

Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting th progenitor endothelial cell to accelerate adhere nce, growth and differentiation of the bound cells into matureand functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vas cular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.

Radiation measuring catheter apparatus and method

An apparatus for measuring radiation at a region of interest inside a body is disclosed. The apparatus comprises a fiber optic equipped-catheter having a distal portion adapted to be inserted in a blood vessel. The apparatus further includes a luminescent scintillation material coupled to the fiber optic light pipe. The scintillation material is disposed in a distal portion of a lumen of the catheter and generates pulses of electromagnetic radiation in response to excitation by radiation rays. The apparatus further includes an index matching material disposed between the scintillation crystal and the fiber optic light pipe facilitating transmission of the pulses of electromagnetic radiation produced by the scintillation material to the fiber optic light pipe. A measuring assembly is coupled to the fiber optic light pipe to convert the pulses of radiation traversing the fiber optic light pipe to a measure of radiation in the region of interest. A method of measuring radiation using the radiation measuring apparatus of the present invention is also disclosed. The steps of the method comprise: providing a catheter having a fiber optic light pipe coupled to a scintillation material supported by a distal portion of the catheter; inserting the distal portion of the catheter through an opening in the body; maneuvering the catheter to position the distal portion of the catheter within the region of interest; and converting the pulses of electromagnetic radiation transmitted along the fiber optic light pipe into a measure of radiation.

Medical device with coating for capturing genetically-altered cells and methods for using same

Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.

Progenitor endothelial cell capturing with a drug eluting implantable medical device

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

Medical device with coating for capturing genetically-altered cells and methods of using same

Medical device with coating that promotes endothelial cell adherence and differentiation

Radiation measuring catheter apparatus and method

An apparatus for measuring radiation at a region of interest inside a body is disclosed. The apparatus comprises a fiber optic equipped-catheter having a distal portion adapted to be inserted in a blood vessel. The apparatus further includes a luminescent scintillation material coupled to the fiber optic light pipe. The scintillation material is disposed in a distal portion of a lumen of the catheter and generates pulses of electromagnetic radiation in response to excitation by radiation rays. The apparatus further includes an index matching material disposed between the scintillation crystal and the fiber optic light pipe facilitating transmission of the pulses of electromagnetic radiation produced by the scintillation material to the fiber optic light pipe. A measuring assembly is coupled to the fiber optic light pipe to convert the pulses of radiation traversing the fiber optic light pipe to a measure of radiation in the region of interest. A method of measuring radiation using the radiation measuring apparatus of the present invention is also disclosed. The steps of the method comprise: providing a catheter having a fiber optic light pipe coupled to a scintillation material supported by a distal portion of the catheter; inserting the distal portion of the catheter through an opening in the body; maneuvering the catheter to position the distal portion of the catheter within the region of interest; and converting the pulses of electromagnetic radiation transmitted along the fiber optic light pipe into a measure of radiation.

Progenitor endothelial cell capturing with a drug eluting implantable medical device

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

Medical device with coating for capturing genetically-altered cells and methods of using same

Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.