FLUGGASTBRÜCKE AND PROCEDURE FOR THE IMPROVEMENT OF THE STABILITY OF A FLUGGASTBRÜCKE

Kinase inhibitors for the treatment of disease

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.

Process for producing biochemical raw material of spore powder of glossy ganoderma

Dust cup structure and cleaning equipment

The invention relates to a dust cup structure and cleaning equipment. The dust cup structure comprises a dust cup cylinder, a separator and a dust cup cleaning structure, a mounting cavity is formed in the dust cup cylinder; the separator is arranged in the mounting cavity, and a filtering outer cavity is formed between the outer wall surface of the separator and the inner wall surface of the mounting cavity; the dust cup cleaning structure comprises at least one cutting piece arranged on the dust cup cylinder, the cutting piece is located in the filtering outer cavity, and the cutting end face of the cutting piece faces and is close to the outer wall face of the separator. The problem that the user experience and the equipment performance are affected due to the fact that the hair wound on the separator of the dust cup is difficult to clean in the prior art can be solved.

KINASE INHIBITORS FOR THE TREATMENT OF DISEASE

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described. 5. The compound of claim 1 , wherein Xis hydrogen or halogen.6. The compound of claim 1 , wherein Xis hydrogen.7. The compound of claim 1 , wherein n is 0 or 1.8. The compound of claim 1 , wherein n is 0.9. The compound of claim 1 , wherein Q is phenyl or 5- or 6-membered heteroaryl.10. The compound of claim 1 , wherein Q is phenyl.11. The compound of claim 1 , wherein Q is substituted with four R.12. The compound of claim 11 , wherein each Ris independently methoxy or chloro.13. The compound of claim 1 , wherein Xis substituted phenyl or methyl.14. The compound of claim 13 , wherein Xis phenyl substituted methylpiperazinyl.15. The compound of claim 1 , wherein Xis substituted phenyl or methyl.17. A pharmaceutical composition comprising a compound of or a pharmaceutically acceptable salt thereof and a pharmaceutical carrier claim 1 , diluent claim 1 , or excipient.18. A pharmaceutical composition comprising a compound of or a pharmaceutically acceptable salt thereof and a pharmaceutical carrier claim 16 , diluent claim 16 , or excipient.19. A method of treating and/or preventing a disease in a subject comprising administering to the subject in need thereof a compound of or a pharmaceutically acceptable salt thereof.20. A method of treating and/or preventing a disease in a subject comprising administering to the subject in need thereof a compound of or a pharmaceutically acceptable salt thereof. This application is a continuation of U.S. application Ser. No. 15/696,309, filed Sep. 6, 2017 (now allowed), which is a continuation of U.S. application Ser. No. 14/903,650, filed Jan. 8, 2016, now U.S. Pat. No. 9,783,504, which is a U.S. National Phase application, filed under 35 U.S.C. § 371, of ...

Manufacturing method of thin film transistor array substrate

The invention relates to a manufacturing method of a thin film transistor array substrate. The manufacturing method respectively adopts three photomasks for a first metal layer, a second metal layer and a third metal layer to form photoresist layers with different heights; and the third metal layer is directly formed on the second metal layer firstly, and then deposition is carried out to form a passivating layer, thus a photomask procedure is omitted. The manufacturing method can simplifies manufacturing process, reduce cost and improve yield.

Transmission belt type carrying device

The invention discloses a transmission belt type carrying device, which is used for carrying and transporting vehicles in a garage. The transmission belt type carrying device comprises an active transmission mechanism, a passive transmission mechanism and a power coupling mechanism, wherein the active transmission mechanism comprises an active transmission table and an active transmission assembly; the active transmission table is arranged in a lifting machine or moving equipment of the garage; the active transmission assembly is arranged on the active transmission table; the passive transmission mechanism comprises a base and a passive transmission assembly; the base is arranged at a parking position of the garage; the passive transmission assembly is arranged on the base; the power coupling mechanism is arranged on at least one end of the active transmission assembly, has a coupling position which is coupled with the passive transmission assembly, and is used for driving the passive transmission ...

Medical waste temporary storage system and method based on artificial intelligence and related equipment

The invention provides a medical waste temporary storage system and method based on artificial intelligence and related equipment. The system comprises a code scanning module used for obtaining identification codes of medical wastes, and the identification codes are used for distinguishing the types of the medical wastes; the controller is used for identifying the authority of the identification code so as to generate a corresponding control signal; the throwing opening is used for responding to the control signal to be opened so as to temporarily store the medical waste into the corresponding temporary storage box, automation of the temporary storage and throwing process of the medical waste is achieved, and the situation that the medical waste is wrongly stored due to misjudgment and negligence operation of an operator is avoided; and the disease transmission risk caused by misplacement of the medical waste is effectively reduced.

Systems and methods for providing image perspective adjustment and automatic fitting

Systems, methods, and non-transitory computer-readable media can provide one or more options to adjust, in a virtual three-dimensional space, an image in an initial perspective. At least a first command, provided based on the one or more options, to adjust the image from the initial perspective into an adjusted perspective can be detected. The image can be adjusted, based on at least the first command, into the adjusted perspective in the virtual three-dimensional space to produce an adjusted image. A second command to modify a viewable area of the adjusted image can be detected. At least a portion of the adjusted image can be automatically fitted, when the second command has ceased, within a specified display area while one or more empty regions can be minimized in the specified display area.

DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

... or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for protein kinases (e.g., Bcr-Abl). The present application also relates to methods for the targeted degradation of one or more protein kinases through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to one or more protein kinases which can be utilized in the treatment of disorders modulated by protein kinases.

HIGH-QUALITY SEAWATER SPIRULINA STRAIN OBTAINED BY SPACE-BREEDING AND USE THEREOF

A space-bred seawater Spirulina H11 strain. The strain exhibits high growth rate, capacity of simultaneously accumulating high contents of phycocyanin, Spirulina polysaccharides and β-carotene, and excellent adaptability to outdoor environment, thus can be used to produce high-quality Spirulina powders, phycocyanin, Spirulina polysaccharides, and β-carotene-rich Spirulina oil.

Methods to treat lymphoplasmacytic lymphoma

The present invention provides compounds of any one of Formulae (I) to (V) ...

HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES

Methods of treatment of conditions or diseases associated with myeloid differentiation primary response (MYD88) protein using a selective HCK inhibitor are provided herein.

Preparation method of nickel-cobalt hydroxide with controllable appearance

The invention discloses a preparation method of nickel-cobalt hydroxide with controllable appearance, belonging to the technical field of chemical engineering and new materials. The preparation method comprises the following steps of: firstly adding an ethylene amine chelating agent into mixed solution of soluble nickel salt and cobalt salt to form metal amine chelating agent solution, fully chelating metal ions and the chelating agent by stirring, then adding alkali metal hydroxide solution into a reaction system, and obtaining hydroxide precipitate by controlling the reaction temperature; and filtering, cleaning and drying the obtained hydroxide precipitate and obtaining the nickel-cobalt hydroxide with a spherical structure or a three-dimensional sisal-shaped structure. The preparation method has the advantages that 1, a new appearance of the nickel-cobalt hydroxide is provided; 2, for the nickel-cobalt hydroxide prepared by using the method provided by the invention, the control for ...

Transportwagen und Parksystem unter Verwendung des Transportwagens

Die vorliegende Erfindung betrifft einen Transportwagen und ein Parksystem unter Verwendung des Transportwagens zum Transport von Fahrzeugen und Ähnlichem. Der vorliegende Transportwagen umfasst einen zur Bewegung geeigneten Hauptkörper und ein Klammermittel, das mindestens erste und zweite bewegliche Platten aufweist, und mindestens ein Paar Klammerklauen. Das vorliegende Parksystem umfasst einen Ladetisch, einen relativ zum Ladetisch beweglichen Differentialtisch, ein relativ zum Differentialtisch beweglichen Transportwagen, eine Längsantriebsvorrichtung, einen Antriebsleitungsübertragungsmechanismus, eine Antriebsventilstation und ein elektrisches Steuersystem dafür. Der erfindungsgemäße Transportwagen ist einfach im Aufbau, realisiert leicht eine flexible und automatische Positionierung, ist geeignet zum Klammern und Heben von Fahrzeugen oder Chassis mit unterschiedlichen Achsabständen und ist geeignet zum bidirektionalen Transport und zum Deponieren und Zurückholen von Fahrzeugen.

Quinoline or quinazoline compound and application thereof

The present invention relates to quinoline or a quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.

Method for preparing multilevel porous carbon base composite phase change material

The invention provides a method for preparing a multilevel porous carbon base composite phase change material, and belongs to the field of composite phase change materials. The method comprises the following steps: at first, preparing an organic metal skeleton material by using such methods as a solution method, a solvothermal method or a stirring synthesis method; with the organic metal skeleton material as a template, high temperature carbonizing under the protection of an inert gas, and changing the carbonizing temperature and the post treatment manner to obtain a multilevel porous carbon material with a super-large specific surface area and a super-large pore volume; selecting proper solvents according to different kinds of phase change core materials, preparing the phase change core materials to a solution, dispersing the porous carbon material into the solution, removing the solvent by such manners as heating, and meanwhile the phase change core materials are adsorbed and limited ...

Use of Erythrina bark extract in preparing antineoplastic medicine

The invention discloses a new use of erythrina bark extract and particularly relates to the application of erythrina bark extract in preparation of antineoplastic drugs. The extract is prepared according to the following method: the erythrina bark extract is extracted from erythrina bark with water and/or an organic solvent as an extractant. The erythrina bark extract provided by the invention is very important for the preparation of antineoplastic medicaments, in particular anti-liver cancer medicaments, anti-lung cancer medicaments, and anti-colon cancer medicaments.

Loading device for testing damping ratio of damper

The invention relates to a loading device for testing a damping ratio of a damper, which belongs to the technical field of space application equipment. The device comprises a loading pulley, a steel cable, small pulleys, a large pulley, a positioning plate, a positioning handle, a loading weight, a support, limit bolts and a limit rod, wherein the positioning plate is fixed on the large pulley; the large pulley is connected with a rotating shaft through a key; the rotating shaft is fixed to the support through a bearing block; both sides of the large pulley are respectively provided with the three pulleys; the positioning plate is positioned at the top end and on the left side of the large pulley; the loading pulley is connected with the small pulleys through the steel cable; the loading weight is connected with the loading pulley through a lifting hook; the positioning handle is positioned in a positioning plate groove of the large pulley; the limit rod is fixed on the rotating shaft of ...

POLYCRYSTALLINE DISPLAY SUBSTRATE AND MANUFACTURING METHOD THEREOF

The present invention relates to a polycrystalline silicon display substrate manufacturing method. The method includes the steps of: providing a substrate including an active device region and a capacitance region; forming a polycrystalline silicon layer over the active device region; forming an insulating layer covering the polycrystalline silicon layer; forming a first conductive layer including a lower electrode arranged on the capacitance region and a gate arranged on the active device region on top of the insulating layer; forming a first high-density doping area and a second high-density doping area on top of the polycrystalline silicon layer; forming a dielectric layer covering the first conductive layer; patterning the dielectric layer and the insulating layer; forming a second conductive later which includes a first source electrode, a first drain electrode, and an upper electrode while enabling the upper and lower electrodes to form a storage capacitor on top of the dielectric ...

Optical system and projector

DEVICE AND METHOD FOR BRIGHTNESS COMPENSATION, MEMORY

A device and a method for brightness compensation and a memory are provided. The method includes: collecting grayscale images corresponding to each of the N grayscales; obtaining brightness values of M pixel points of each of the N grayscale images; grouping the M pixel points according to the brightness values of each of the M pixel points under N grayscales to obtain a plurality of pixel groups; calculating a brightness compensation factor of the pixel group under each grayscale according to an average brightness value of each pixel group under each grayscale to obtain the brightness compensation factors of each pixel group under N grayscales respectively; and building a lookup table of the brightness compensation factor according to the brightness compensation factors. The brightness compensation method provided in the disclosure improves the brightness evenness and the display effect of the display, and saves the storage space of the display.

METHOD AND APPARATUS FOR ANIMATING TRANSITION AMONG DYNAMIC GRAPH SERIES

A method and an apparatus for animating transition among a dynamic graph series including a preceding graph and a succeeding graph which are temporally sequentially displayed. The method includes: selecting an unchanged node which is the nearest to a removed node and merging through animation the removed node with the unchanged node, thereby animating removal of the removed node; and selecting an unchanged node which is the nearest to an added node and splitting through animation the added node from the unchanged node, thereby animating addition of the added node. During the animation, the moving distances of the nodes can be shortened, and the crossing of movement paths and the crossing of graph edges can be prevented during the movement of the nodes, thereby visualizing smoothly and clearly transition among dynamic graph series.

METHOD AND APPARATUS OF ANIMATION PLANNING FOR A DYNAMIC GRAPH

A method and apparatus of animation planning for a dynamic graph is provided. A first method includes grouping changed nodes into atomic partitions according to the relationships between the changed nodes and existing nodes. The next step is clustering the atomic partitions according to clustering distances between the atomic partitions to generate a running list for planning animation of node changes in the dynamic graph. The running list includes elements selected from the group consisting of clusters of atomic partitions and atomic partitions. The present invention is able to plan a multi-stage animation demonstration of changes of a dynamic graph and has a improved readability and animation speed.

Pharmaceutical composition and application replacing quinolone derivative, pharmaceutical acceptable salt, or stereoisomer

Provided are a pharmaceutical composition, as indicated by Formula (I), and an application thereof in preparing a tumor prevention drug, replacing a quinolone derivative or a pharmaceutical acceptable salt, and a prodrug molecule. The quinolone derivative, salt, prodrug and pharmaceutical composition thereof can serve as a protein kinase inhibitor, effectively inhibiting AXL protein kinase activity and cell growth, migration and invasion of a plurality of tumor cells, and being applicable to preparing a tumor prevention drug, and specifically, to a drug treating an excessive proliferative disease such as a tumor for human being and other mammals.

Methods to treat lymphoplasmacytic lymphoma

The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) ( ...

Upper jaw central incisor turns up and rescues ware

The utility model belongs to the technical field of be used for correcting the tooth device, concretely relates to upper jaw central incisor turns up and rescues ware, including holding in the palm cell body and magnetism apron, ask the cell body to be the cuboid structure, the bottom surface of holding in the palm the cell body is connected with the tooth surface, rectangle arch wire groove that the front interlude runs through in being provided with closely far, the front of holding in the palm the cell body is provided with the spout, the spout includes two magnetism slides of buckling, two magnetism slide symmetries of buckling set up in rectangle arch wire groove both sides, insert in the magnetism of the buckling slide the magnetism apron. The utility model discloses an upper jaw central incisor turns up and rescues ware, structural design is reasonable, installs smallly, bonds on the tooth surface, can not upset and go up the palate mucous membrane, can not oppress the gum mucous ...

Processing method for heavy oil

A processing method for heavy oil comprises: (1) mixing a solvent and heavy oil, and then separating the solvent and heavy oil to obtain an oil phase and a solvent phase, wherein the solvent contains 10m%-100m% of a composition A and 0-90m% of water, the composition A is one or more of C2-C4 polyols and polyhydroxy ethers prepared by performing condensation on two or three C2-C4 polyols, and the solvent accounts for 1%-30% by volume of heavy oil; and (2) performing desalination and/or dewatering processing on the oil phase. The method used for performing desalination and/or dewatering processing on heavy oil has relatively good effect.

Application of stephania tetrandra extract in preparing anti-tumor medicaments

The invention discloses a new use of the extract of radix stephaniae tetrandrae. The new use is the application of the extract of radix stephaniae tetrandrae for preparing antineoplastic drugs. The extract is prepared according to the following method: the root of the radix stephaniae tetrandrae is used as raw material, and the extract is obtained by extracting in water or organic solvent. The new use of the extract of the radix stephaniae tetrandrae of the invention has important significance to prepare the antineoplastic drugs, especially the medicine for resisting liver cancer, colon cancer or lung cancer.

Water quality monitoring device convenient to remove in pasture and water

The utility model discloses a water quality monitoring device convenient to remove in pasture and water, including the monitoring box, be provided with the water quality monitoring system that can stretch into to the aquatic in the monitoring box, the front end of monitoring box is provided with coniform head, and the rear end is provided with the screw, the screw overcoat is equipped with the pasture and water protection casing of surperficial trompil, it is used for the drive still to be provided with in the monitoring box the motor of screw and with the storage battery that motor electricalconnects. Can be in the continuous removal in pasture and water flourish's waters, the water quality monitoring of long -time different positions carries out to preserve the data of monitoring in real time, realized full -automatic working, overcome artifical on -the -spot data collection's defect.

Central base station, integrated system and control method of central base station

The invention discloses a central base station, an integrated system and a control method of the central base station. The central base station comprises: a base station body; the dust collection mechanism is arranged on the base station body and at least comprises a dust collection cavity and a dust collection impeller communicated with the dust collection cavity; the purification mechanism is arranged on the base station body, and the purification mechanism at least comprises a purification impeller; the driving mechanism can be switched between a dust collection state and a purification state, and in the dust collection state, the driving mechanism is used for driving the dust collection impeller to rotate relative to the base station body; and in the purification state, the driving mechanism is used for driving the purification impeller to rotate. According to the technical scheme provided by the invention, the functions of the central base station are more diversified, the structure ...

Methods to treat lymphoplasmacytic lymphoma

The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase.

Quinoline or quinazoline compound and application thereof

The present invention relates to quinoline or a quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.

QUINOLINE OR QUINAZOLINE COMPOUND AND APPLICATION THEREOF

The present invention relates to quinoline or a quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase.

KINASE INHIBITORS FOR THE TREATMENT OF DISEASE

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.

SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals. 7. The substituted quinolone derivative claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof according to claim 1 , characterized in being one of the following compounds:N-(3-fluoro-4-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)-1,2,6-trimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide6-chloro-N-(3-fluoro-4-((3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamideN-(4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-3-fluorophenyl)-6-chloro-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide6-chloro-N-(3-fluoro-4-((5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamideN-(3-fluoro-4-((5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide7-chloro-N-(3-fluoro-4-((5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide5-chloro-N-(3-fluoro-4-((5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)-1,2-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamideN-(3-fluoro-4-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)-1,2-dimethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide6-fluoro-N-(3-fluoro-4-((5-phenyl-7H- ...

An auxiliary supporting device for an air passenger bridge and an air passenger bridge with the auxiliary supporting device and the method of control the air passenger bridge

Raisin tree seed extract and preparation method and use thereof in preparing anti-tumor medicine

The invention discloses an extract from raisin tree seed and a preparing method thereof as well as the application in antineoplastic medicine preparation. The method takes water and/or organic solvent as the extraction agent and obtains the extract from the raisin tree seed; wherein, the organic solvent is carbinol, ethanol, petroleum ether, chloroform, methylene dichloride, ethyl acetate, normal butanol, benzene or toluene. The circumfluence extraction temperature is between 60 and 100 DEG C; the extraction time is at least one; and the extracting time for each is between 1 and 4 hours. The method has the advantages of simple technique and low cost, the extract effectively restrains the growth of the tumour cells such as liver cancer cell, colon cancer cell and lung cancer cell. The raisin tree seed extract provided by the invention has great significance on preparing the tumour medicine, in particular to medicine resisting liver cancer and colon cancer.

Intelligent check anti-maloperation method based on real-time trend

The invention relates to an intelligent check anti-maloperation method based on a real-time trend. By taking an electric power system model, a figure and real-time operation mode data as a basis, an intelligent anti-maloperation check program, before a dispatcher performs power network control, according to a current power network model and a running state, rapidly and automatically carries out a series of checks including a basis operation rule check, a dispatcher trend calculation check and a backup automatic switching rule check, wherein the basis operation rule check covers five universal protection rules and a topology check rule, and can carry out anti-maloperation check on equipment, an interval, a whole station and even a whole network; the dispatcher trend calculation check, through dynamic trend calculation, monitors the voltage and current values of a transformer, a bus and a line and gives a prompt about operation leading to off-limit; and the backup automatic switching rule ...

Centralized treatment device for water hyacinth in river

The invention belongs to the technical field of water hyacinth centralized treatment devices, and discloses a river water hyacinth centralized treatment device which comprises a ship body and protective shells, the front face of the ship body is fixedly connected with a salvage conveying device, and the protective shells are fixedly connected to the two sides of the ship body. After water hyacinths are crushed through the cutter assembly, the crushed water hyacinths are stacked at the bottom of the cutting mechanism, and at the moment, when the second shaft rod and the cutting mechanism are driven by the movable rod sleeve to retreat, the water hyacinths are separated from the water hyacinths. One side of a second shaft rod is movably meshed with a first gear to drive a first shaft rod, the first shaft rod is pushed in a chute at the bottom of the ship body, and when the first shaft rod is pushed, a pinch roller mechanism at the bottom of the ship body rolls the crushed water hyacinth, ...

Inspection data processing method and device, computer equipment and storage medium

The invention relates to an inspection data processing method and device, computer equipment, a storage medium and a computer program product. According to the method, the model parameters of the neural network model can be analyzed based on the trained neural network model to obtain the target model data, and the inspection data is processed and analyzed by using the target model data, so that the processing efficiency of the inspection data is improved. Besides, the target model data and the to-be-processed inspection data are input into the processor with the accelerated deep learning algorithm, so that the processor can quickly obtain the data and execute the operation of reasoning calculation, and output the inspection identification information obtained after the reasoning calculation is executed, and the processing efficiency of the inspection data is further improved.

Concrete precast slab construction manufacturing device

The invention belongs to the technical field of precast slabs, and discloses a concrete precast slab construction manufacturing device which comprises a plate making tool, a protective shell and a photographing device, the protective shell is fixedly connected to one side of the plate making tool, a sliding groove is formed in the top of the protective shell, and a supporting pipe fitting is vertically arranged in the sliding groove in the top of the protective shell in a bent mode; when a second internal and external tooth belt pulley rotates clockwise, a rotating crankshaft part is driven to rotate simultaneously, and when the rotating crankshaft part rotates, a telescopic vibration part is driven to pulse the bottom of a partition plate part through up-and-down stretching of a return spring, so that the central area of the partition plate part vibrates, and concrete at the top of the partition plate part is uniformly and tightly vibrated; the problems that a large amount of physical ...

TROLLEY AND PARKING SYSTEM USING THE SAME

The present invention relates to a trolley and parking system using the same for transporting cars and the like. The present trolley includes a main body, capable of moving; and a clamping means, having at least a first and a second moving plates and at least a pair of clamping claws. The present parking system includes a loading table, a differential table moving relative to the loading table, a trolley moving relative to the differential table, a longitudinal driving device, a power tube line transmission mechanism, and a power valve station and an electric control system thereof. The trolley of the present invention is simple in structure, easy to realize flexible and automatic positioning, capable of clamping and lifting cars or car chassis of different wheelbase, and capable of realizing bidirectional transporting and depositing or retrieving cars. © KIPO & WIPO 2007 ...

High-quality seawater Spirulina strain obtained by space-breeding and use thereof

A space-bred seawater Spirulina H11 strain. The strain exhibits high growth rate, capacity of simultaneously accumulating high contents of phycocyanin, Spirulina polysaccharides and β-carotene, and excellent adaptability to outdoor environment, thus can be used to produce high-quality Spirulina powders, phycocyanin, Spirulina polysaccharides, and β-carotene-rich Spirulina oil.

LAYOUT METHOD AND SYSTEM IN A DISPLAY AREA FOR DISCONNECTED DYNAMIC NETWORKS

A layout method in a display area for multiple graph components in a dynamic network. The multiple graph components are sorted according to their importance into a first subset S1 and a second subset S2 according to the order of their importance. The first subset S1 is divided into an upper subset Cp including only the most important graph component and a lower subset Cm. The display area is divided into display portions S1 and S2 proportionally according to the importance values of the first subset S1 and the second subset S2. Display portion S1 is divided into display portions Cp and Cm proportionally according to the importance values of the upper subset Cp and the lower subset Cm. The first division and the second division and the corresponding division of the display area are executed iteratively until the aspect ratio of display portion Cp is close to 1.

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-l) to (1-9)), and methods for treating Waldenstrom' s macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin- 1 receptor- associated kinase 1 (IRAKI), interleukin- 1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase- 1 (TAK1), and/or a Src family kinase.

Biological oral liquid

The biological oral liquid for improving immunity, suppressing tumor and bacteria, increasing functions of liver, kidney, stomach and intestine, and curing neurasthenia with obvious effect contains tonic Chinese-medicinal components such as astragalus root, ginseng, pilose asiabell root, siberian solomonseal rhizome, honey, etc. and useful living bacteria such as lactobacillus, difidobacteria, etc.

Method and device for conversing sampling rate

The invention relates to a method and a device for conversing sampling rate. An up and down conversing sample method is used for at least one time in order to converse an input signal from an input sampling rate to a transitional sampling rate, wherein in the simplest integer ratio of the transitional sampling rate and the input sampling rate, the numerator and the denominator are all the smallest integer as far as possible. The input signal is conversed from the transitional sampling rate to the target sampling rate by using the interpolation method for at least one time. The invention combines the advantages of interpolation method and the up and down conversing sample method, wherein the relative small value of the numerator and denominator of the simplest integer ratio is beneficial to greatly decrease the arithmetic complexity by using the up and down conversing sample method and the property has no obvious loss.

Alternating ring-opening metathesis polymerization

The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization.

HYDROPHOBICALLY TAGGED JANUS KINASE INHIBITORS AND USES THEREOF

The present invention provides Janus kinase inhibitors, such as compounds of Formula (I) and Formula (II) wherein Rand Rcomprise a tagged hydrophobic moiety R. The compounds may covalently or non-covalently bind a kinase (e.g., Janus kinase 3 (JAK3)). The hydrophobic moiety Rmay signal to the intracellular protein homeostasis machinery to induce degradation of the targeted kinase. Also provided are pharmaceutical compositions, kits, methods, and uses that involve the compounds for reducing the activity of a kinase and/or treating and/or preventing a condition associated with aberrant activity of a kinase (e.g., a proliferative disease, inflammatory disorder, autoimmune disorder, painful condition, and/or viral infection). 315-. (canceled)16. The compound of claim 1 , wherein both Rand Rare hydrogen.1719-. (canceled)20. The compound of claim 1 , wherein a is 1 or 2 and at least one instance of Ris halogen.21. The compound of claim 1 , wherein each of R claim 1 , R claim 1 , and Ris hydrogen.2223-. (canceled)29. (canceled)3233-. (canceled)3637-. (canceled)39. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable excipient.40. A method of reducing the activity of a kinase in a subject in need thereof claim 1 , the method comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , in an amount sufficient to reduce the activity of the kinase.41. A method of treating a condition associated with aberrant activity of a kinase in a subject in need thereof claim 1 , the method comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , in an amount sufficient to treat the condition.4250-. (canceled)51. The method of claim 41 , wherein the condition is a proliferative disease claim 41 , inflammatory disorder claim 41 , autoimmune disorder claim 41 , painful ...

HCK degraders and uses thereof

Provided herein are bifunctional compounds with a moiety ( ...

Cough relieving traditional Chinese medicine composition and preparation method thereof

The invention provides a cough relieving traditional Chinese medicine composition and a preparation method thereof. The cough relieving traditional Chinese medicine composition is composed of the raw materials including bryozoatum, honeysuckle, commelina diffusa, liquorice, loquat leaves, pericarpium citri reticulatae, fructus perillae, houttuynia cordata, platycodon grandiflorum, white granulated sugar, radix scutellariae, asarum, ginger, roxburgh rose roots and semen plantaginis. The cough relieving traditional Chinese medicine composition provided by the invention is capable of effectively treating cough through bryozoatum, honeysuckle, commelina diffusa, liquorice, loquat leaves, pericarpium citri reticulatae and the like; and furthermore, the cough relieving traditional Chinese medicine composition is rapid to take effect, short in treatment course and difficult to relapse.

Mix sand gravel skip

The utility model discloses a mix sand gravel skip, through set up support (2) on car hopper (1), be equipped with hopper (3) of terminal surface for the V -arrangement on support (2), be equipped with feed inlet (4) in the upper end of hopper, lower extreme at the hopper is equipped with discharge gate (5), be equipped with on support (2) of discharge gate (5) lower extreme band conveyer (7), one end at band conveyer is equipped with ejection of compact elbow (8), and simultaneously, it prevents the putty device to be equipped with on hopper (3), can cooperate the sand spreader to lay, compared with the prior art, the utility model discloses can play the effect of similar ordinary merchant's concrete car, be used for transporting and carry mix gravel building stones, can improve the efficiency of laying of the mix bed of material that the rubble is young and the grit is formed and the steady bed of material of water greatly, it is very convenient that the use is got up to that lays is ...

Optical fiber ceramic core automatic grinder and automatic grinding method

The invention relates to an automatic grinder for an optical fiber ceramic insert core and an automatic grinding method. The grinder comprises a stander, a power system arranged on the stander, a grinding system extended out of the stander and driven by the power system, a lifting system arranged on the stand, a pressure system driven by the lifting system to move up and down and a control system, wherein the pressure system and the grinding system are arranged oppositely. The automatic grinding method is as follows: an optical fiber ceramic insert core to be processed is arranged on the grinding system, and the lifting system is controlled to drive the pressure system to compress the fiber ceramic insert core to be processed; the grinding system begins working to grind the lower end face of the fiber ceramic insert core to be processed; and through monitoring pressure change of the pressure system, the control system controls ascending or descending of the lifting system according to the ...

Organic composition of ultrafine sheet copper powder and preparation method of organic composition

The invention discloses an organic composition of ultrafine sheet copper powder and a preparation method of the organic composition. The method includes the steps of firstly, complexing a copper sulfate solution, and conducting adjustment to make the PH of the solution range from 12 to 14; secondly, adding an organic composition composed of polyvinylpyrrolidone and tetrahydroglyoxaline type ampholytic surfactant, making the organic composition automatically form a micelle soft template in the solution, and inducing copper ion reduction; thirdly, adding a reducing agent solution, conducting reaction for 30 minutes to 180 minutes under the ultrasonic condition, and taking sediment on the lower layer to be washed, centrifuged and dried to obtain dry ultrafine sheet copper powder. The method overcomes the defects of the preparation process for preparing copper through the chemical reduction on the aspects of the preparation process and product performance, the ultrafine sheet copper powder ...

Method capable of improving density of sintering type metal binding agent grinding apparatus

The invention discloses a sintering metal binding agent grinding apparatus, and a method for machining the sintering metal binding agent grinding apparatus. The sintering metal binding agent grinding apparatus comprises a grinding material, first-level metal powder and second-level metal powder. The median diameter D50 of the first-level metal powder ranges from 150 micrometers to 20 micrometers, and the median diameter D50 of the second-level metal powder ranges from 0.2 micrometer to 15 micrometers. The sintering metal binding agent grinding apparatus has the advantages of being low in voidage, high in density and holding force, and long in service life under the heavy loads.

Manufacturing method of thin film transistor array substrate

The invention relates to a manufacturing method of a thin film transistor array substrate, comprising the steps of: firstly forming a pixel electrode and a grid electrode; then forming a grid electrode insulation layer and a semiconductor channel by different heights of photoetching adhesive layers; and finally forming a thin passivation layer film though a stripping method. The pixel electrode is connected with a drain electrode without penetrating the thin passivation layer film, thus a photomask process is omitted. The invention simplifies the manufacturing process, reduces the cost and enhances the output.

Thin film transistor manufacturing method

The invention provides a thin film transistor manufacturing method which includes the steps: providing a substrate; forming a gate metal layer on the substrate; patterning the gate metal layer to form gate electrodes; sequentially forming a gate oxide layer, a semiconductor layer and an ohmic contact layer on gate lines; forming a laminated conducting film on a gate insulating layer and the ohmic contact layer; patterning the laminated conducting film to form drain electrodes and source electrodes serving as data lines. The laminated conducting film is provided with a first Mo metal layer, an Ag metal layer and a second Mo metal layer which are sequentially laminated. Compared with the prior art, the thin film transistor manufacturing method has the advantages that the manufactured drain electrodes and the manufactured source electrodes are of Mo/Ag/Mo laminated structures, current etching liquid can be directly used for finishing etching procedures when the requirement of a large-sized ...

Loading device for testing damping ratio of damper

The invention relates to a loading device for testing a damping ratio of a damper, which belongs to the technical field of space application equipment. The device comprises a loading pulley, a steel cable, small pulleys, a large pulley, a positioning plate, a positioning handle, a loading weight, a support, limit bolts and a limit rod, wherein the positioning plate is fixed on the large pulley; the large pulley is connected with a rotating shaft through a key; the rotating shaft is fixed to the support through a bearing block; both sides of the large pulley are respectively provided with the three pulleys; the positioning plate is positioned at the top end and on the left side of the large pulley; the loading pulley is connected with the small pulleys through the steel cable; the loading weight is connected with the loading pulley through a lifting hook; the positioning handle is positioned in a positioning plate groove of the large pulley; the limit rod is fixed on the rotating shaftof ...

Methods of creating patterns on substrates and articles of manufacture resulting therefrom

Methods of creating patterns on substrates are presented, and articles of manufacture resulting therefrom. One method comprises applying a first surface energy modifier to an applicator to form a coating on the applicator; contacting the coating with a receiving member, the receiving member having a topography, the coating only contacting and remaining on at least some protrusions; exposing the first modified receiving member to a second surface energy modifier, thereby forming a second modified receiving member having surface modified recesses; applying a composition comprising a polymeric material to the second modified receiving member, the composition substantially conforming to the topography of the surface modified protrusions and the surface modified recesses; and contacting the composition-coated, surface modified protrusions with a substrate for a time and under conditions sufficient to transfer the polymeric material on protrusions to the substrate. Because the surface energy ...

AMOLED display device

The present disclosure provides an AMOLED display device, which comprises a main control processor, a driving integrated chip (IC), a power management chip, and a pulse control line. The power management chip generates a voltage signal, after receiving the digital signal. The power management chip comprises an identification (ID) generation module. The ID generation module comprises a control protocol of the power management chip. The ID generation module is configured to generate an ID signal of the power management chip according to the control protocol of the power management chip.

HCK as a therapeutic target in MYD88 mutated diseases

Methods of treatment of conditions or diseases associated with myeloid differentiation primary response (MYD88) protein using a selective HCK inhibitor are provided herein.

Methods to treat lymphoplasmacytic lymphoma

The present invention provides compounds of any one of Formulae (I) to (V) ...

Continuous fermentation device

The utility model relates to a continuous fermentation device, including tower reactor and circulating pump, tower reactor includes exocoel and inner chamber, and there is the feed inlet inner chamber bottom, inner chamber top and solid water gas separat chamber intercommunication, gu the both sides in water gas separat chamber have discharge gate and circulation discharge gate respectively, the discharge gate is higher than the circulation discharge gate, gu there is the gas vent at water gas separat chamber top, gu the water gas separat intracavity is equipped with the baffle of slope, the side of baffle and the interior wall connection in solid water gas separat chamber, the top and the bottom of baffle are all gapped with solid -liquid separation intracavity wall, and the bottom of baffle lies in discharge gate homonymy below, and the top of baffle lies in circulation discharge gate homonymy top, exocoel lower part one side is equipped with the water inlet, and exocoel upper portion ...

QUICK AND ACCURATE INTEREST-CALCULATING TABLE

Electrostatic discharge current suppression circuit, display and equipment terminal

The invention relates to an electrostatic discharge current suppression circuit, an OLED display and a device terminal.The suppression circuit comprises an electrostatic discharge clamping unit used for conducting first-stage attenuation on electrostatic discharge current of an input power source; the decoupling unit is used for performing second-stage attenuation on the output current of the electrostatic discharge clamping unit, the decoupling unit comprises a plurality of decoupling subunits which are connected in parallel, each decoupling subunit comprises a switching tube capacitor and a protective resistor which are connected in series, one end of the protective resistor is connected with the output end of the electrostatic discharge clamping unit, and the other end of the protective resistor is connected with the output end of the electrostatic discharge clamping unit. According to the suppression circuit, the gate control end of each switch tube capacitor is independently connected ...

Compound resveratrol anti-inflammatory and itching relieving medicament combination and purpose thereof

The invention provides a pure traditional Chinese medicine compound preparation for external use (such as ointment, film agent, gel and tincture), which is used for treating pruritus caused by eczema-dermatitis and mosquito biting and does not contain hormonal. The compound is prepared from resveratrol, glycyrrhizic acid or physiologically acceptable salts of glycyrrhizic acid or glycyrrhetinic acid or physiologically acceptable salts of glycyrrhetinic acid, ginghaosu and derivates thereof, menthol or borneol composition. Proved by experiments and clinical tests, the compound resveratrol anti-inflammatory and itching relieving medicament combination has the functions of resisting inflammation, restraining bacteria and relieving itching aiming at the characteristics of pruritus caused by eczema-dermatitis and mosquito biting and has specific curative effect for pruritus caused by eczema-dermatitis and mosquito biting. The invention has the advantages of nontoxic raw materials, low price ...

Use of ormosia seed extract in preparing anti-tumor medicament

The invention discloses a novel application of coralhead plant seed extract, pertaining to the application of coralhead plant seed extract in the preparation of anti-tumor medicines. The extract is prepared by the following method that: coralhead plant seeds are taken as raw materials and extracted with water and/or organic solvent to obtain the extract. The coralhead plant seed extract provided in the invention has great significance for the preparation of anti-tumor medicines, especially the medicines for treating liver cancer, lung cancer and colon cancer.

System and methods for using limit-use encrypted code to transfer values securely among users

A system and method for facilitating a secured value transfer. A first user and the system obtain a pair of encryption and decryption apparatuses. The first user creates a request including his unique identifier and a value to be transferred. The first user encrypts the request using the encryption apparatus and sends it to the second user. The second user sends to the system the request and the second user's unique identifier. The system uses the decryption apparatus to decrypt the request. The system checks the usage of the request against a threshold limit. After a successful usage check, the system then transfers the value from the first user to the second user. The system may comprise (a) a plurality of system server for exchanging data with users' personal computing devices, registering users, and conducting transactions, and (b) data storages storing user accounts and other persistent data.

METHOD OF MANUFACTURING AN LTPS ARRAY SUBSTRATE

The present disclosure discloses a method of manufacturing the LTPS array substrate, comprising: depositing a polysilicon layer and an amorphous silicon layer on the substrate successively and crystallizing the amorphous silicon layer to form the polysilicon layer by laser annealing; coating a photoresist layer covering the PMOS area, NMOS area and TFT area of the polysilicon layer; forming a polysilicon pattern and a channel by dry etching the polysilicon layer, then removing the regions of the photoresist layer which are thinner and covering the NMOS area and the TFT area by ashing, the region of the photoresist layer covering the PMOS area is remained. The present disclosure saves the cost of the equipment, improves the yield, reduces the design defect and the process difficulty of the conventional process using 8 photomasks. 1. A method of manufacturing an LTPS array substrate , comprising:(a) providing an LTPS pre-structure with a polysilicon layer surface; wherein an NMOS area, a PMOS area and a TFT area are predefined in the LTPS pre-structure;(b) forming a photoresist layer covering the PMOS area, the NMOS area and the TFT area; wherein a region of the photoresist layer covering the PMOS area is thicker than those covering the NMOS and TFT area;(c) exposing the surface of the NMOS area and TFT area in the LTPS pre-structure; and(d) implanting ions into the NMOS area and TFT area.2. The method as claimed in further comprising the steps of:screening the P-type channel of the NMOS area, the P-type channel of the PMOS area and the P-type TFT area and performing the ion implantation process to form an N-type source area, an N-type drain area and an N-type TFT area;depositing a gate electrode, forming a first metal layer, and defining the gates;screening the N-type channel of the NMOS area and the N-type TFT area and performing the ion implantation process to form the P-type source area, the N-type drain area;forming contact holes on the source, drain, gate of the ...

Pharmaceutical composition and application replacing quinolone derivative, pharmaceutical acceptable salt, or stereoisomer

Provided are a pharmaceutical composition, as indicated by Formula (I), and an application thereof in preparing a tumor prevention drug, replacing a quinolone derivative or a pharmaceutical acceptable salt, and a prodrug molecule. The quinolone derivative, salt, prodrug and pharmaceutical composition thereof can serve as a protein kinase inhibitor, effectively inhibiting AXL protein kinase activity and cell growth, migration and invasion of a plurality of tumor cells, and being applicable to preparing a tumor prevention drug, and specifically, to a drug treating an excessive proliferative disease such as a tumor for human being and other mammals.

Use of heaven tree extract in preparing antineoplastic medicine

The invention discloses a new use of heaven tree extract. The new use lies in that the heaven tree extract is used for preparing antineoplastic drugs; the heaven tree extract is prepared according to the following method: heaven tree skin is used as raw material which is then extracted by water and/or an organic solvent to obtain the extract. The heaven tree extract provided by the invention is of significance in preparing antineoplastic drugs, especially drugs for resisting liver cancer, lung cancer and colon cancer.

Applications of fructus psoraleae extractive on preparing antitumor medicines

The invention discloses a new usage of a psoralea fruit extract, in particular to an application of the psoralea fruit extract in preparing antitumor medicines. The extract is prepared by the method containing the following steps: water and/or organic solvent are used as extractant, and the psoralea fruit extract is extracted and obtained from the seeds of psoralea fruit. The new usage of psoralea fruit extract provided by the invention has important significance for preparing antitumor medicines and especially for hepatic cancer resistance medicines.

Method for manufacturing basal plate of film transistor array

The invention relates to a method for manufacturing a basal plate of a film transistor array, which comprises the following steps: after a grid electrode and an insulation layer of the grid electrodeare formed, a pixel electrode is firstly formed, a semiconductor layer and a drain electrode metal layer are secondly formed by using different heights of photo-resist layers and a stripping method, and a film of a passivation layer is formed at last. A pixel electrode does not need to penetrate the film of the passivation layer to be connected with the drain electrode, thus, the invention saves alight shield procedure, simplifies the production process, reduces the cost and increases the output.

Method for optimizing state of aluminum conductor of overhead insulated distribution line

The invention relates to an overhead insulation distribution line aluminum conductor state optimization method comprising the following steps: S1, obtaining structure data and environment data of an overhead insulation distribution line, and determining analysis requirements; s2, establishing a heat balance equation of the temperature of the aluminum conductor of the overhead insulated distribution line based on the structural data and the environmental data, and calculating the temperature of the aluminum conductor in the conductor when current transition does not occur by using the heat balance equation; and S3, acquiring a transition current, obtaining an analysis result according to an analysis requirement and the temperature of the aluminum conductor in the wire when current transition does not occur, and optimizing the operation state of the wire based on the analysis result. Compared with the prior art, the method has the advantages of accurate calculation of the internal conductor ...

Method and apparatus of animation planning for a dynamic graph

METHOD FOR JUDGMENT OF CHEDDAR GRADE BASED ON IDENTIFICATION CHARACTERISTIC FLAVOR COMPOSITION

The present invention discloses a method for judgment of cheddar cheese grade based on identification characteristic flavor compounds, comprising the following steps: selecting cheddar cheese of different grades as standard product, and extracting volatile flavor compounds from the standard product; using gas phase-sniffing device to screen out characteristic flavor compounds with higher flavor intensity from the volatile flavor compounds through aroma extract dilution analysis; proceeding with clustering of characteristic flavor compounds as screened out to obtain identification characteristic flavor compounds of cheddar cheese; measuring the concentration of identification characteristic flavor composition of cheddar cheese of known grade, and establish the training set for training of support vector machine; measuring the concentration of identification characteristic flavor composition of cheddar cheese to be tested, and inputting it into the support vector machine trained to judge the grade of cheddar cheese to be tested. The present invention aims to obtain the model of identification characteristic flavor compounds of cheddar cheese through statistical analysis, which is available for accurate judgment of cheddar cheese quality grade on this basis. 1. A method for judgment of cheddar cheese grade based on identification characteristic flavor compounds , characterized in that the method comprises the following steps:(1) selecting cheddar cheeses of different grades as standard products, and extracting volatile flavor compounds from the standard products;(2) using a gas phase-sniffing device to screen out characteristic flavor compounds with higher flavor intensity from the volatile flavor compounds through aroma extract dilution analysis;(3) proceeding with clustering of characteristic flavor compounds as screened out in the step (2) to obtain the identification characteristic flavor compounds of cheddar cheeses;(4) measuring concentrations of the ...

Kinase inhibitors for the treatment of disease

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.

Methods to treat lymphoplasmacytic lymphoma

The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) ( ...

Donkey hide gelatin injection plasma substitutes and preparation method thereof

The invention relates to a donkey-hide glue injection plasma substitute. The invention is prepared by the following raw materials by weight: 2-5 parts of donkey-hide glue, 0.6-1 part of sodium chloride for injection and 100 parts of distilled water for injection. The preparation method is shown as follows: the donkey is cleaned, killed and skinned, and after the hair and the adipose layer on the hide are removed, the hide is sterilized, disinfected, washed and decocted into gelatin. The gelatin is degraded at high temperature, filtered, refined, condensed, frozen, dried, ground and screened to prepare donkey-hide dry powder. Then, donkey-hide dry powder, sodium chloride for injection and distilled water for injection are weighed according to the weight proportion mentioned above, and stirred evenly with a vacuum mixing machine, filtered and packaged to prepare the donkey-hide glue injection plasma substitute. The invention has the advantage that the invention provides a donkey-hide glue ...

Preparation method of multilevel-structure titanium dioxide based composite phase-change material

The invention discloses a preparation method of a multilevel-structure titanium dioxide based composite phase-change material. The method comprises the following steps of preparing monodispersed silicon dioxide microspheres; preparing composite microspheres with silicon dioxide/titanium dioxide core-shell structures; preparing multilevel-structure titanium dioxide microspheres; preparing the multilevel-structure titanium dioxide based composite phase-change material. The preparation method of the multilevel-structure titanium dioxide based composite phase-change material belongs to the technical field of energy-saving and energy-storage materials. A loading type composite phase-change material is prepared by loading a phase-change material with excellent properties of high energy-storage density, high heat conductivity and the like on a multilevel-structure titanium dioxide, and the combination properties of the solid loading ability, the cyclical stability and the like of the phase-change ...

Distributed simulation method and system for multiple unmanned systems

The invention discloses a distributed simulation method and system for multiple unmanned systems. The method comprises the steps that distributed simulation tasks of the multiple unmanned systems are decomposed into a distributed virtual simulation network, a perception control sub-network and a DDS-based cooperative communication service network according to three logic concepts of virtual simulation, control perception and task cooperation; a virtual simulation task with multiple unmanned system task collaboration is deployed on distributed nodes; rule arbitration judgment, map scene management, real-time state synchronization, multi-point session management, intelligent simulation and real-time situation sharing services are provided through a comprehensive server of the distributed virtual simulation network. A client of a distributed virtual simulation network is used for providing local computing functions including dynamics, collision interaction, damage simulation and graphic rendering ...

ADVERTISER PREDICTION SYSTEM

Disclosed is a method for supporting online services in providing content items to users of an online system. A request for loading a webpage of an online system is received from a client device. A plurality of content items eligible for being presented to the user is received. For each of the received content items, a trained model is identified based on characteristics of the content item, and a score is determined using the identified trained model and based on characteristics of the user. One or more content items is selected based on the determined scores. The selected one or more content items are sent to the client device for presentation to the user. 1. A method comprising:receiving a request, from a client device, for loading a webpage of an online system, the request including an identification of a user of the online system;receiving a plurality of content items eligible for being presented to the user, the user associated with a page in the online system, the page having content available for viewing by other users of the online system; identifying a trained model based at least in part on a type of the content item,', 'determining a score for the content item using the identified trained model, and based at least in part on characteristics of the user;, 'for each of the content itemsselecting one or more content item based on the determined scores; andsending the selected one or more content items to the client device for presentation to user.2. The method of claim 1 , further comprising:receiving feedback from the client device regarding an interaction of the user with a first content item sent for presentation to the user;identifying a trained model based at least in part on a type of the first content item; andupdating the trained model based on the received feedback.3. The method of claim 2 , wherein the feedback is one of the user clicking a link associated with the first content item claim 2 , the user performing an action associated with the ...

An auxiliary supporting device for an air passenger bridge and an air passenger bridge with the auxiliary supporting device and the method of control the air passenger bridge

Comprehensive utilization method of PTA production waste water

The invention provides a method for comprehensively utilizing PTA production wastewater. The method comprises the following steps: the PTA production wastewater is used as injecting water for desalting crude oil, the PTA production wastewater is fully mixed with hydrocarbon raw materials and a demulsifier, which ensures that metals in the hydrocarbon raw materials can generate water soluble complexes that can change from oil phase into water phase, part of organic substances in the PTA production wastewater are changed from water phase to oil phase, and then the oil and the water are separated, thus achieving the purpose of removing metals from hydrocarbon oil, and the organic substances in the PTA production wastewater are dissolved into the hydrocarbon oil, thus achieving the purposes of reducing COD in the drained water, and lightening the burden of the subsequent wastewater treatment.

Method for purifying dermatan sulfate from heparin byproduct

The invention discloses a method for purifying dermatan sulfate from a heparin byproduct. The method comprises the following steps of: using the heparin byproduct as a raw material; dissolving the heparin byproduct, and then adding potassium acetate into the dissolved heparin byproduct; adjusting the pH value of solution by using acetic acid to generate a deposit, wherein clear solution is sulfate polysaccharide solution; adding a Ban's agent and saturated sodium hydroxide solution into the sulfate polysaccharide solution; centrifugally collecting the deposit; performing re-precipitation; dissolving the deposit again; washing away copper ions by using a chromatography column with anion exchange properties and sodium chloride solution; performing linear gradient elution by using the sodiumchloride solution; collecting eluant; and evaporating and concentrating the eluant, and depositing the eluant by using ethanol to obtain high-purity dermatan sulfate. The method has the advantages ofsimple ...

Process for producing biochemical raw material of spore powder of glossy ganoderma

The method for producing biochemical raw material with glossy ganoderme spore powder includes such technological steps as boiling said spore powder, cooling to 60 deg.C, addition of enzyme, further cooling, inoculating saccharomycetes, fermentation and repeating cooling-boiling-laying aside at normal temp. several times. The nucleic acid, amino acids and active matter to directly kill cancer cells are released from spore powder, and used to produce medicine, food, cosmetics, drink and daily-use articles.

Audio coding and decoding method and apparatus

The invention discloses an audio encoding method and a corresponding decoding method, which help transient audio signals to avoid preliminary echoes and minimize the distortion of the transient audio signals. The invention adopts the technical proposal that: the transient signals inputted into the audio are processed with time domain treatment; the sampling points x1, x2,,,xN of the inputted frame are divided into L segments; wherein N is the length of the inputted frame and L is any natural number less than N; the energy Ei of each segment is calculated, wherein i is a natural number from 1 to L; the average energy E0 of the segments of the inputted frame is calculated; the multiplicative coefficient corresponding to each segment is calculated: (Lambada)i = r(bitrate)*E0/Ei, wherein i is a natural number from 1 to L, and r(bitrate) is a function correlative with bit rate; sampling points of all the segments of the inputted frame are multiplied by corresponding multiplicative coefficients ...

Trapezoid coil-type permanent-magnetic coreless linear motor

The invention relates to a trapezoid coil-type permanent-magnetic coreless linear motor which comprises a stator basal body, a stator winding, a rotor basal body and a Halbach permanent-magnetic array, the stator is located right above the stator with an air gap, a rotor winding is wound on the stator basal body, the rotor winding is formed by mutually connecting trapezoid coils, the trapezoid coil is a coil of which the sections of two element edges are trapezoid in cross sections, a Halbach permanent-magnetic array is mounted on a lower surface of the rotor basal body, both of the stator basal body and rotor basal body are made of aluminium alloy materials. Thin layer coils of current Halbach permanent-magnetic coreless linear motor are replaced by utilizing the trapezoid coils, 5-time, 9-time pulsing power generated by the motor is greatly reduced, therefore improving power output smoothness of the motor, the motor has a wide application prospect in the superhigh-precision servo field ...

Simply make rounds of wards and use shallow

The utility model provides a simply make rounds of wards and use shallow, which relates to the field of medical instrument, the toughened glass storage apparatus comprises a pedestal, the liftable stand is installed at the top of this base, the bottom of base is equipped with a plurality of casters, wherein, the liftable stand includes stand and lower stand, bottom fixed mounting in the top of base of lower stand, go up the inside of stand top -down activity cartridge stand under in, and the lateral wall cartridge of stand has a control to go up the fixed screw that the stand goes up and down down, can adjust the height of liftable stand as required at any time, it uses to be convenient for medical personnel, two minor faces of platform are buckled downwards respectively and are extended and form a curb plate, hang on every curb plate and are equipped with storage basket. The integrated level is high, has both satisfied the requirement of hospital's information construction, and the health ...

Production method of biological Chakangdan egg

The production method of biological tea disease-resisting health-care egg is characterized by that the tea and animal placenta powder are added into the feed for egg-laying poultry and water, and theisolation feeding process of egg-laying poultry and male poultry is adopted. Said invented egg has good quality and taste, long fresh-keeping time, and possesses the health-care functions of building-up body, raise intelligence, nourishing face, preventing diseases, resisting senility and resisting cancers.

Preparation method of nickel-cobalt hydroxide with controllable appearance

The invention discloses a preparation method of nickel-cobalt hydroxide with controllable appearance, belonging to the technical field of chemical engineering and new materials. The preparation method comprises the following steps of: firstly adding an ethylene amine chelating agent into mixed solution of soluble nickel salt and cobalt salt to form metal amine chelating agent solution, fully chelating metal ions and the chelating agent by stirring, then adding alkali metal hydroxide solution into a reaction system, and obtaining hydroxide precipitate by controlling the reaction temperature; and filtering, cleaning and drying the obtained hydroxide precipitate and obtaining the nickel-cobalt hydroxide with a spherical structure or a three-dimensional sisal-shaped structure. The preparationmethod has the advantages that 1, a new appearance of the nickel-cobalt hydroxide is provided; 2, for the nickel-cobalt hydroxide prepared by using the method provided by the invention, the control for ...

Method for preparing flavobacterium heparinum heparinase I

The invention provides a method for preparing heparinase I. The method for preparing the heparinase I comprises the following steps of: inoculating flavobacterium heparinum serving as a raw material to a seed culture medium for culture; then inoculating the flavobacterium heparinum to a fermentation culture medium; centrifugally collecting precipitate; performing ultrasonication on the precipitate; performing centrifugation again to obtain crude enzyme liquid of the flavobacterium heparinum heparinase I; and performing SP-sepharose FF chromatographic purification on the crude enzyme liquid for three times to obtain the high-purity flavobacterium heparinum heparinase I, wherein the SP-sepharose FF chromatographic purification for three times is protected by calcium chloride in the whole course, so that the yield of pure enzymic activity is greatly increased. The method for preparing the heparinase I has the characteristics of simple process, easy amplification, large preparation amount of ...

Manufacturing method of LTPS array substrate

The invention provides a manufacturing method of LTPS array substrate. The method comprises the following steps: a buffer layer and a non-crystal silicon layer are deposited on the substrate in order, a laser annealing process is conducted to make the non-crystal silicon layer into polycrystalline layer; photoresist is coated respectively on P-channel area, N-channel area and TFT area of the polycrystalline layer, the thickness of the photoresist on P-channel area is more than two times than that of the photoresist on N-channel area or that of the photoresist on TFT area, no photoresist remains on the rest part thereof; polycrystalline pattern and channels are formed by way of dry etching of polycrystalline layer, then the thinner photoresist on N-channel area and TFT area is removed by photoresist ashing treatment and photoresist on P-channel area remains.

Kinase inhibitors for the treatment of disease

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.

Preparation method of quaternary ammonium salt and halogenated lithium-containing fractal aggregate

The invention belongs to the field of material and fractal, in particular to a preparation method of quaternary ammonium salt and halogenated lithium-containing fractal aggregate. The method comprises the steps of: firstly inserting dimethyl diallyl ammonium chloride monomers among montmorillonite layers to obtain dimethyl diallyl ammonium-montmorillonite; dispersing the dimethyl diallyl ammonium-montmorillonite into hydrosolvent to have in situ polymerization so as to obtain poly-dimethyl diallyl ammonium-montmorillonite; dispersing the poly-dimethyl diallyl ammonium-montmorillonite into tetrahydrofuran solvent; extracting poly-dimethyl diallyl ammonium-halogenated lithium with tetrahydrofuran solution of lithium chloride to obtain composite micelle of poly-dimethyl diallyl ammonium-lithium chloride; and dropping the poly-dimethyl diallyl ammonium-lithium chloride onto a cleaning substrate, and naturally volatilizing the solvent in room-temperature air to obtain the aggregate with fractal ...

Technique for glycosylated degradation of white spirit waste lees to prepare fermentalbe sugar

The invention relates to a technique for glycosylated degradation of white spirit waste lees to prepare fermentalbe sugar, which includes the procedures of drying and grinding of the white spirit waste lees, glycosylated degradation, the separation of saccharic acid, and the like. The technique is as follows: mixing ground waste lees with hydrogen chloride with mass fraction of 2% according to mass per unit volume of 1:10 for glycosylated degradation and collecting the filtrate; letting the filtrate pass through a chromatographic column which is filled with anionic resin, eluting through distilled water and collecting the eluate by step; and combining the eluates with sugar content equal to or more than 0.5 to be recovered sugar liquid. The recovered sugar liquid can be used as material for alcohol fermentation or other fermentations after being concentrated, and the used anionic exchange resin can be regenerated through NaOH. The concentration of the reducing sugar in the recovered sugar ...

Use of pepperweed seed extract in preparing anti-tumor medicine

The invention discloses a tansymustard seed extract and the application in the preparation of antitumor medicines. Water and/or organic solvent is adopted as extractant to obtain extract from tansymustard seed; the tansymustard seed extract can effectively inhibit the growth of human tumor cells, such as human liver cancer cells, colon cancer cells or lung cancer cells. Thereby, the tansymustard seed extract has great importance in the preparation of anticancer medicines, in particular to the anticancer medicines for liver cancer, lung cancer and colon cancer.

Method for cultivating sweet wormwood herb with high artemisinin content in flower buds by co-transforming Sps, Hmgr and Dxs genes

The invention discloses a method for cultivating sweet wormwood herb with high artemisinin content in flower buds by co-transforming Sps, Hmgr and Dxs genes, relating to the technical field of biology. The method comprises the following steps: cloning three genes namely Anti-Sps, Anti-Hmgr and Anti-Dxs genes from sweet wormwood herb, constructing a plant expression vector containing three genes namely the Sps, Hmgr and Dxs genes which are combined in pairs, performing mediation by using agrobacterium, transferring the three genes namely the Sps, Hmgr and Dxs genes into sweet wormwood herb, and cultivating and screening regenerated plants to obtain a transgenic sweet wormwood herb plant with increased artemisinin content in the flower buds. When the content of non-transformed comparison sweet wormwood herb is 6.20mg/g of dry weight, the maximum artemisinin content in the flower buds of an obtained gene engineering sweet wormwood herb plant disclosed by the invention is 12.10mg/g of dry weight ...

METHOD OF GENERATING AN INTELLECTUAL PROPERTY BLOCK DESIGN KIT, METHOD OF GENERATING AN INTEGRATED CIRCUIT DESIGN, AND SIMULATION SYSTEM FOR THE INTEGRATED CIRCUIT DESIGN

The present application discloses a method of generating an intellectual property (IP) block design kit including an IP block circuit design and a system-level characteristics table for manufacturing an integrated circuit. According at least one embodiment, the IP block circuit design is generated. The IP block circuit design is simulated based on predetermined configuration sets, and each configuration set has manufacturing options and/or operating conditions. A plurality of system-level models for the predetermined configuration sets are generated based on the simulation of the IP block circuit design. The system-level characteristics table is generated by arranging the predetermined configuration sets and the system-level models in compliance with a system-level characteristics table template of a system-level characteristics modeling device. Then the IP block circuit design and the system-level characteristics table are stored as the IP block design kit. 1. A method of generating an intellectual property (IP) block design kit including an IP block circuit design and a system-level characteristics table for manufacturing an integrated circuit , the method comprising:generating the IP block circuit design;simulating the IP block circuit design based on two or more predetermined configuration sets, each configuration set comprising manufacturing options and/or operating conditions;generating a plurality of system-level models for the predetermined configuration sets based on the simulation of the IP block circuit design;generating the system-level characteristics table by arranging the predetermined configuration sets and the system-level models in compliance with a system-level characteristics table template of a system-level characteristics modeling device; andgenerating the IP block design kit based on the IP block circuit design and the system-level characteristics table.2. The method of claim 1 , wherein the simulation of the IP block circuit design comprising ...

BIAXIALLY ORIENTED POLYPROPYLENE FILM SUBSTRATE FREE FROM PRIMER COATING AND FILM FREE FROM PRIMER COATING

Disclosed is a biaxially oriented polypropylene film substrate free from primer coating, which comprises successively connected affinity layer, core layer and surface layer, said affinity layer comprises 10% to 80% by weight of polypropylene homopolymer, 10% to 80% by weight of polyolefin plastomer and 1% to 10% by weight of anti-adhesion agent; said core layer is polypropylene homopoiymer; said surface layer is the same as the affinity layer or a non-coated surface layer that comprises 90% to 99% by weight of polypropylene homopolymer and 1% to 10% by weight of anti-adhesion agent. A film free from primer coating and its preparing method are also provided. The coated film of this invention does not need the process of primer pre-coating which reduces the relevant equipment costs on one hand and avoids the safety risks when using and restoring solvent type primer on the other. 1. A biaxially oriented polypropylene film substrate which is free from primer , characterized in that it comprises successively connected affinity layer , core layer and surface layer , the affinity layer comprises 10% to 80% by weight of polypropylene homopolymer , 10% to 80% by weight of polyolefin plastomer and 1% to 10% by weight of anti-adhesion agent; the core layer is polypropylene homopolymer; the surface layer is the same as the affinity layer or a non-coated surface layer , said non-coated surface layer comprises 90% to 99% by weight of polypropylene homopolymer and 1% to 10% by weight of anti-adhesion agent.2. The biaxially oriented polypropylene film substrate according to claim 1 , characterized in that the thickness of the affinity layer is 1 μm to 10 μm.3. The biaxially oriented polypropylene film substrate according to claim 1 , characterized in that the thickness of the non-coated surface layer is 1 μm to 10 μm.4. The biaxially oriented polypropylene film substrate according to claim 1 , characterized in that the total thickness of the biaxially oriented polypropylene film ...

Isopeptide Bond Formation in Bacillus Species and Uses Thereof

A mechanism for a unique isopeptide bond formation between polypeptides is disclosed as well as sequence motifs used in such bond formation and methods of using such sequence motifs.

Automatically tuning a transmitter to a resonance frequency of a receiver

Various embodiments of a wirelessly powered local computing environment are described. The wireless powered local computing environment includes at least a near field magnetic resonance (NFMR) power supply arranged to wirelessly provide power to any of a number of suitably configured devices. In the described embodiments, the devices arranged to receive power wirelessly from the NFMR power supply must be located in a region known as the near field that extends no further than a distance of a few times a characteristic size of the NFMR power supply transmission device. Typically, the distance can be on the order of 1 meter or so. The NFMR power supply is used to tune a transmitter in order to maintain a high Q factor.

ELECTRODE TREATMENT PROCESS FOR ORGANIC ELECTRONIC DEVICES

The present invention relates to a process for the treatment of electrodes in organic electronic (OE) devices, in particular organic field effect transistors (OFETs), to devices prepared by such a process, and to materials and formulations used in such a process. 2. Process according to claim 1 , characterized in that in the compounds of formula I Rand R claim 1 , together with each other and with the 5-membered heterocycle to which they are attached claim 1 , form a benzene ring wherein one or two CH groups are optionally replaced by N claim 1 , and wherein said ring is unsubstituted or substituted by 1 claim 1 , 2 claim 1 , 3 or 4 groups R.3. Process according to claim 1 , characterized in that in the compounds of formula I Rand R claim 1 , together with each other and with the 5-membered heterocycle to which they are attached claim 1 , form a benzene claim 1 , pyridine or pyrimidine ring which is unsubstituted or substituted by 1 claim 1 , 2 claim 1 , 3 or 4 non-aromatic groups R.6. Process according to claim 1 , characterized in that in formula I claim 1 , I1 and I11-I15 Ris H claim 1 , SH claim 1 , NH claim 1 , -alkylene-SH claim 1 , wherein alkylene denotes a straight-chain or branched alkylene group with 1 to 18 C atoms claim 1 , or C-Cthiaalkyl claim 1 , and R denotes claim 1 , on each occurrence identically or differently claim 1 , F or C-Cperfluoroalkyl.7. Process according to claim 1 , characterized in that in formula I claim 1 , I1 and I11-I15 at least one group Ror R denotes P-Sp- claim 1 , wherein P and Sp are as defined for the compound of formula I.9. Process according to claim 1 , characterized in that it comprises the following stepsa) depositing source and drain electrodes onto a substrate, or onto a gate insulator layer,b) optionally washing the source and drain electrodes,c) depositing a layer of a compound of formula I, or of a formulation comprising a compound of formula I and optionally one or more solvents, in the area between the source and ...

STYLUS ORIENTATION DETECTION

Stylus orientation detection is disclosed. In an example, the orientation of a stylus relative to a contacting surface, e.g., a touch panel, can be detected by detecting a capacitance at one or more locations on the stylus relative to the surface, and then using the capacitance(s) to determine the orientation of the stylus relative to the surface. In another example, the orientation of a stylus relative to a contacting surface, e.g., a touch panel, can be detected by first detecting the orientation of the stylus relative to a reference, detecting the orientation of the contacting surface relative to the reference, and then calculating the orientation of the stylus relative to the contacting surface using the two detected orientations. 1. A method for detecting an orientation of an input device , comprising:detecting a first capacitance at a first location on the input device;detecting a second capacitance at a second location on the input device;correlating the first and second capacitances; andcalculating the orientation of the input device based on the correlation.2. The method of claim 1 , wherein detecting the first capacitance comprises:capturing an image of the first capacitance on a touch sensitive surface; anddetermining a location of the image of the first capacitance.3. The method of claim 1 , wherein detecting the second capacitance comprises:capturing an image of the second capacitance on a touch sensitive surface; anddetermining a location of the image of the second capacitance.4. The method of claim 1 , wherein correlating the first and second capacitances comprises:determining proximity of the detected first and second capacitances relative to each other in an image; anddetermining relative position of the detected first and second capacitances in the image.5. The method of claim 1 , wherein calculating the orientation of the input device comprises:determining the orientation based on at least one of a proximity or relative position of locations ...

Test Schemes and Apparatus for Passive Interposers

A probe card includes a plurality of probe pins, and a switch network connected to the plurality of probe pins. The switch network is configured to connect the plurality of probe pins in a first pattern, and reconnect the plurality of probe pins in a second pattern different from the first pattern.

FORMULATION AND METHOD FOR PREPARATION OF ORGANIC ELECTRONIC DEVICES

The present invention relates to novel formulations comprising an organic semiconductor (OSC) and one or more organic solvents. The formulation comprises a viscosity at 25° C. of less than 15 mPas and the boiling point of the solvent is at most 400° C. Furthermore, the present invention describes the use of these formulations as inks for the preparation of organic electronic (OE) devices, especially organic photovoltaic (OPV) cells and OLED devices, to methods for preparing OE devices using the novel formulations, and to OE devices, OLED devices and OPV cells prepared from such methods and formulations. 1. Formulation comprising one or more organic semiconducting compounds (OSC) , and one or more organic solvents , characterized in that said formulation comprises a viscosity at 25° C. of less than 15 mPas and the boiling point of the solvent is at most 400° C.2. Formulation according to claim 1 , characterized in that said formulation comprises a viscosity at 25° C. in the range of 0.5 to 9.5 mPas.3. Formulation according to claim 1 , characterized in that said formulation is a solution.4. Formulation according to claim 1 , characterized in that said formulation comprises a surface tension in the range of 22 mN/m to 50 mN/m.5. Formulation according to claim 1 , characterized in that said organic solvent comprises Hansen Solubility parameters of Hin the range of 17.0 to 23.2 MPa claim 1 , Hin the range of 0.2 to 12.5 MPaand Hin the range of 0.0 to 20.0 MPa.6. Formulation according to claim 5 , characterized in that said organic solvent comprises Hansen Solubility parameters of Hin the range of 17.0 to 23.2 MPa claim 5 , Hin the range of 0.2 to 10.5 MPaand Hin the range of 0.0 to 5.0 MPa.7. Formulation according to claim 1 , characterized in that said organic solvent comprises one or more of an aromatic and/or heteroaromatic compound.8. Formulation according to claim 7 , characterized in that said organic solvent comprises of one or more aromatic hydrocarbon compound. ...

PROCESS FOR MODIFYING ELECTRODES IN AN ORGANIC ELECTRONIC DEVICE

The present invention relates to a process for modifying the electrodes in an organic electronic (OE) device, in particular an organic field effect transistor (OFET), and to an OE device prepared by using such a process. 1. Process of modifying electrodes in an organic electronic device , comprising the steps ofa) providing an electrode, or two or more electrodes, comprising a first metal,b) depositing onto said electrode(s) a layer of a second metal having a higher normal electrode potential than the first metal,c) optionally exposing said layer of second metal to a composition comprising an organic compound containing a functional group that interacts with the surface of said second metal, andd) depositing onto the electrode(s), and/or in the area between said electrodes, an organic semiconductor layer.2. Process according to claim 1 , characterized in that the second metal has a higher work function than the first metal.3. Process according to claim 1 , characterized in that the first metal is selected from the group consisting of Cu claim 1 , Al claim 1 , Sn and Zn.4. Process according to claim 1 , characterized in that the second metal is selected from the group consisting of Ag claim 1 , Au claim 1 , Co claim 1 , Cu claim 1 , Ir claim 1 , Ni claim 1 , Pd claim 1 , Pt claim 1 , Rh and Re.5. Process according to claim 1 , characterized in that the layer of the second metal is deposited by electroless plating.6. Process according to claim 1 , characterized in that the layer of the second metal is deposited by an ion exchange process.7. Process according to claim 1 , characterized in that the layer of the second metal is deposited by immersing the electrode in a bath containing ions of the second metal.8. Process according to claim 7 , characterized in that the bath does not contain any reducing agent for the ions of the second metal.9. Process according to claim 7 , characterized in that the bath contains an organic compound containing a functional group that ...

PLANARIZATION LAYER FOR ORGANIC ELECTRONIC DEVICES

The invention relates to organic electronic devices containing polycycloolefin planarization layers between the substrate and a functional layer like a semiconducting layer, dielectric layer or electrode, to the use of polycycloolefins as planarization layer on the substrate of an organic electronic device, and to processes for preparing such polycycloolefin planarization layers and organic electronic devices. 1. An organic electronic device comprising a substrate , and provided on said substrate a functional layer selected from semiconducting layers , dielectric layers and electrodes , wherein a planarization layer is provided between the substrate and the functional layer , wherein said planarization layer comprises a polycycloolefinic polymer.2. The organic electronic device of claim 1 , wherein the polycycloolefinic polymer is a norbornene-type polymer.3. The organic electronic device of claim 1 , wherein the polycycloolefinic polymer comprises two or more distinct types of repeating units.4. The organic electronic device of claim 1 , wherein the polycycloolefinic polymer comprises a first type of repeating unit having a pendant crosslinkable group.5. The organic electronic device of claim 4 , wherein the pendant crosslinkable group is a latent crosslinkable group.6. The organic electronic device of claim 5 , wherein the pendant crosslinkable group comprises a substituted or unsubstituted maleimide portion claim 5 , an epoxide portion claim 5 , a vinyl portion claim 5 , an acetylene portion claim 5 , an indenyl portion claim 5 , a cinnamate portion or a coumarin portion.8. The organic electronic device of claim 4 , wherein the polycycloolefinic polymer comprises a second type of repeating units having a pendant silyl group.14. The organic electronic device of claim 1 , wherein the planarization layer is derived from a polymer composition comprising one or more of a solvent claim 1 , a crosslinking agent claim 1 , an optional reactive solvent claim 1 , a ...

System and methods for using limit-use encrypted code to transfer values securely among users

A system and method for facilitating a secured value transfer. A first user and the system obtain a pair of encryption and decryption apparatuses. The first user creates a request including his unique identifier and a value to be transferred. The first user encrypts the request using the encryption apparatus and sends it to the second user. The second user sends to the system the request and the second user's unique identifier. The system uses the decryption apparatus to decrypt the request. The system checks the usage of the request against a threshold limit. After a successful usage check, the system then transfers the value from the first user to the second user. The system may comprise (a) a plurality of system server for exchanging data with users' personal computing devices, registering users, and conducting transactions, and (b) data storages storing user accounts and other persistent data.

ALKENE ISOMERIZATION AS AN ENTRY TO EFFICIENT ALTERNATING RING-OPEINING METATHESIS POLYMERIZATION (i-AROMP)

This invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. Specifically, the present invention provides a polymer comprising rigorously alternating AB subunits and methods of formation of the AB alternating polymers. In the polymers and process of the invention, the A monomer is derived from a cyclobutene derivative, and the B monomer is derived from a cyclohexene derivative. The polymerization takes place in the presence of an olefin metathesis catalyst. 3. The process according to or , wherein Rand Rare taken together to form a 5- or 6-membered ring , which may optionally contain up to 2 heteroatoms in the ring selected from O or N , and which may be unsubstituted or substituted with up to four substituents selected from halo , CN , NO , oxo , amino , alkyl , cycloalkyl , alkenyl , alkynyl , aralkyl , aryl , and a heterocyclic group.4. The process according to or , wherein Rand Rare taken together to form a cyclohexyl ring , which may be optionally substituted.10. The process according to or , wherein Rand Rare taken together to form a 5- or 6-membered ring , which may optionally contain up to 2 heteroatoms in the ring selected from O or N , and which may be unsubstituted or substituted with up to four substituents selected from halo , CN , NO , oxo , amino , alkyl , cycloalkyl , alkenyl , alkynyl , aralkyl , aryl , and a heterocyclic group.11. The process according to claim 10 , wherein Rand Rare taken together to form a cyclohexyl ring claim 10 , which may be optionally substituted. This application claims priority to U.S. Application No. 62/136,436, filed Mar. 20, 2015, which is incorporated herein by reference in its entirety.This invention was made with government support under grant numbers GM097971, HD38519, and GM74776 awarded by the National Institutes of Health. The government has certain rights in the invention.This invention relates to the field of polymers and olefin ...

FORMULATIONS CONTAINING A MIXTURE OF AT LEAST TWO DIFFERENT SOLVENTS

The present invention relates to formulations for the preparation of organic electronic devices which comprise at least one organic functional material and a mixture of at least two different solvents wherein a first organic solvent exhibits a lower boiling point than a second organic solvent and said first organic solvent exhibits a higher viscosity than said second organic solvent. 119.-. (canceled)20. A formulation comprising at least one organic functional material , and organic solvents , wherein said formulation comprises a mixture of at least two different solvents wherein a first organic solvent exhibits a lower boiling point than a second organic solvent and said first organic solvent exhibits a higher viscosity than said second organic solvent.21. The formulation according to claim 20 , wherein said second solvent exhibits a viscosity in the range of 0.5 to 50 mPas at 25.0° C.22. The formulation according to claim 20 , wherein the difference between the viscosities of said second solvent and said first solvent is in the range of 1 to 50 mPas at 25.0° C.23. The formulation according to claim 20 , wherein said second organic solvent has a boiling point in the range from 100° C. to 350° C. claim 20 , wherein the boiling point is given at 760 mm Hg.24. The formulation according to claim 20 , wherein the difference between the boiling point of said first organic solvent and the boiling point of said second organic solvent is in the range of 5° C. to 100° C.25. The formulation according to claim 20 , wherein the formulation comprises at least 20% of the first and second solvent.26. The formulation according to claim 20 , wherein said first organic solvent comprises parameters of Hin the range of 15.5 to 22.0 MPa claim 20 , Hin the range of 0.0 to 12.5 MPaand Hin the range of 0.0 to 15.0 MPa.27. The formulation according to claim 20 , wherein said second organic solvent comprises Hansen Solubility parameters of Hin the range of 15.5 to 22.0 MPa claim 20 , Hin the ...

SIGNAL TRANSMISSION CIRCUIT

A signal transmission circuit is provided. A tri-state logic circuit includes an enabling terminal, an input terminal and an output terminal, and is conducted and unconducted when the enabling terminal is at a high and a low state respectively. A pull-up circuit pulls up a voltage level of the output terminal. A first and a second multiplexers respectively output an enabling signal and an output signal to the enabling terminal and the input terminal according to a first status of a selection signal and respectively output a high state signal according to a second status of the selection signal. A selection circuit generates the selection signal having the first status when the voltage level is not larger than a first threshold value, having the second status after the voltage level is larger than the first threshold value and having the first status afterwards. 1. A signal transmission circuit , comprising:a tri-state logic circuit comprising an enabling terminal, an input terminal and an output terminal and configured to be conducted when the enabling terminal is at a high state and unconducted when the enabling terminal is at a low state;a pull-up circuit electrically coupled to the output terminal and configured to pull up a voltage level of the output terminal;a first multiplexer and a second multiplexer respectively configured to output an enabling signal to the enabling terminal and output an output signal having a low state to the input terminal according to a first status of a selection signal, and respectively configured to output a high state signal to the enabling terminal and output the high state signal to the input terminal according to a second status of the selection signal opposite to the first status; anda selection circuit configured to generate the selection signal having the first status when the voltage level of the output terminal is not larger than a first threshold value, generate the selection signal having the second status during a ...

METHODS AND REAGENTS FOR ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS

The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications and other nucleic acid sequence interrogations. In some embodiments, provided methods provide non-amplification based targeted enrichment strategies compatible with the use of molecular barcodes for error correction. Other embodiments provide methods for non-amplification based targeted enrichment strategies compatible with direct digital sequencing (DDS) and other sequencing strategies (e.g., single molecule sequencing modalities and interrogations) that do not use molecular barcoding. 1. A method for enriching target nucleic acid material , comprising:providing a nucleic acid material;cutting the nucleic acid material with one or more targeted endonucleases so that a target region of predetermined length is separated from the rest of the nucleic acid material;enzymatically destroying non-targeted nucleic acid material;releasing the target region of predetermined length from the targeted endonuclease; andanalyzing the cut target region.2. The method of claim 1 , wherein enzymatically destroying non-targeted nucleic acid material comprises providing an exonuclease enzyme.3. The method of claim 1 , wherein enzymatically destroying non-targeted nucleic acid material comprises providing one or more of an exonuclease enzyme and an endonuclease enzyme.4. The method of claim 1 , wherein the destroying comprises at least one of enzymatic digestion and enzymatic cleavage.5. The method of any one of - claim 1 , wherein the one or more targeted endonucleases remain bound to the target region during the enzymatically destroying step.6. The method of any one of - claim 1 , wherein at least one targeted endonuclease is a ribonucleoprotein complex comprising a capture label claim 1 , and wherein the target region of predetermined length is physically separated from the rest ...

PATTERNED BANK STRUCTURES ON SUBSTRATES AND FORMATION METHOD

A photolithiographic method for fabricating bank structures with improved non-wetting properties to form well regions on a substrate using a photoresist composition comprising a cresol novolak resin, a photoactive diazonaphthoquinone sulfonic ester of a polyhydroxybenzophenone compound with at least one free hydroxyl group, and a non-ionic urethane polyglycol fluorosurfactant. Inkjet methods can be used to deposit active materials into the well areas. Color filter arrays and optoelectronic devices such as OLED devices can be made by this method. 133.-. (canceled)34. A method for fabricating bank structures that define well regions on a substrate comprising in order , the steps of:a. preparing a solution comprising a cresol novolak resin, a photoactive diazonaphthoquinone sulfonic ester of a polyhydroxybenzophenone compound with at least one free hydroxyl group, and a non-ionic urethane polyglycol fluorosurfactant;b. coating the solution over the substrate to form a film;c. heating the coated substrate to remove any solvent;d. using a radiation source and a photomask to expose the coated substrate in a pattern;e. developing the substrate to remove the thin film in one of the exposed or unexposed regions so that the unremoved material in the other region form banks that define well regions of uncovered substrate; andf. heating the developed substrate.35. The method according to claim 34 , wherein in step a) claim 34 , the concentration of cresol novolak resin in the solution is 30% by weight or less.36. The method according to claim 34 , wherein the non-ionic urethane polyglycol fluorosurfactant contains poly(ethylene glycol) groups.37. The method according to claim 36 , wherein the non-ionic urethane polyglycol fluorosurfactant contains a group derived from a perfluoroalkyl group with a terminal hydroxyl or carboxyl group.38. The method according to claim 34 , wherein the diazonaphthoquinone sulfonic ester of a polyhydroxybenzophenone compound is a 2-diazonaphtho-1- ...

Test Socket With Hook-Like Pin Contact Edge

The present invention provides a test socket adaptable for testing different Integrated Circuit (IC) pad size during an IC testing. The test socket comprising a molded socket having an inner space and a plurality of through-apertures disposed on its surface; and a plurality of contact elements disposed within the inner space of the molded socket, each contact element has a pin contact edge and a pin-end; wherein each pin contact edge extends through the through-apertures of the molded socket; wherein each pin contact edge provides a linear surface area for contact with the DUT's lead; and wherein each pin contact edge provides a large contact area for various DUT's lead size. 1. A test socket adaptable for testing a Device Under Test (DUT) with leads , the test socket comprising:a molded socket having an inner space and a plurality of through-apertures disposed on its surface;a floating nest supported by a plurality of springs on top of the molded socket, Wherein the DUT is placed onto the floating nest during test; anda plurality of contact elements disposed within the inner space of the molded socket, each contact element has a pin contact edge and a pin-end,wherein each pin contact edge extends through the through-apertures of the molded socket for contacting with the DUT during test;wherein each pin contact edge defines a linear surface area for contacting with the DUT's lead; andwherein each pin contact edge provides a large contact area relative to contact top for various DUT's lead size.2. The test socket according to claim 1 , wherein the contact elements are aligned together in pairs in consecutive rows claim 1 , each pair positioned to contact a corresponding DUT's lead.3. The test socket according to claim 2 , wherein each pair of the contact elements are in a mirror image configuration.4. The test socket according to claim 1 , wherein the pin contact edge is alike a sharp arrow angled at least 45° diagonally upwards.5. (canceled)6. (canceled)7. (canceled ...

THIN-FILM TRANSISTORS WITH LOW CONTACT RESISTANCE

Techniques are disclosed for forming thin-film transistors (TFTs) with low contact resistance. As disclosed in the present application, the low contact resistance can be achieved by intentionally thinning one or both of the source/drain (S/D) regions of the thin-film layer of the TFT device. As the TFT layer may have an initial thickness in the range of 20-65 nm, the techniques for thinning the S/D regions of the TFT layer described herein may reduce the thickness in one or both of those S/D regions to a resulting thickness of 3-10 nm, for example. Intentionally thinning one or both of the S/D regions of the TFT layer induces more electrostatic charges inside the thinned S/D region, thereby increasing the effective dopant in that S/D region. The increase in effective dopant in the thinned S/D region helps lower the related contact resistance, thereby leading to enhanced overall device performance. 1. A transistor comprising:a gate electrode including one or more metals;a gate dielectric on the gate electrode;a layer on the gate dielectric, the layer including one or more metals, the layer also including oxygen;a first contact structure on the layer, the first contact structure including one or more metals, a first portion of the layer between the first contact structure and the gate dielectric; anda second contact structure on the layer, the second contact structure including one or more metals, a second portion of the layer between the second contact structure and the gate dielectric, wherein the first portion of the layer has a first thickness, the second portion of the layer has a second thickness, and a third portion of the layer between the first and second portions of the layer has a third thickness, the third thickness greater than the first thickness, and the third thickness the same as the second thickness.2. The transistor of claim 1 , wherein the first contact structure is a source contact structure claim 1 , and the second contact structure is a drain ...

CONTACT ARRANGEMENT, CIRCUIT BOARD, AND ELECTRONIC ASSEMBLY

A contact arrangement, including multiple contacts, is provided. The contacts are staggered. Some of the contacts form at least one contact group. The at least one contact group includes a first contact and six second contacts. The second contacts are arranged around the first contact. When the first contact is a power contact or a ground contact, the second contacts are signal contacts. When the first contact is a signal contact, three of the second contacts are power contacts or ground contacts and are not adjacent to each other. 1. A contact arrangement , comprising:{'claim-text': ['a first contact; and', 'six second contacts, arranged around the first contact, wherein', 'when the first contact is a power contact or a ground contact, the plurality of second contacts are signal contacts, and', 'when the first contact is a signal contact, three of the plurality of second contacts are power contacts or ground contacts and are not adjacent to each other.'], '#text': 'a plurality of contacts, being staggered, wherein a plurality of the plurality of contacts form at least one contact group, and the at least one contact group comprises:'}2. The contact arrangement according to claim 1 , wherein the first contact is equidistant from each of the plurality of second contacts.3. The contact arrangement according to claim 1 , wherein a number of the at least one contact group comprises two claim 1 , and the plurality of contact groups are independent of each other.4. The contact arrangement according to claim 1 , wherein a number of the at least one contact group comprises multiple claim 1 , and the plurality of contact groups share one or two of the plurality of second contacts.5. The contact arrangement according to claim 1 , wherein when the first contact is a signal contact and the other three of the plurality of second contacts are signal contacts claim 1 , the plurality of second contacts as power contacts or ground contacts and the plurality of second contacts as ...

CONTACT ARRANGEMENT, CIRCUIT BOARD, AND ELECTRONIC ASSEMBLY

A contact arrangement, including multiple contacts, is provided. The contacts are staggered. Some of the contacts form at least one contact group. The at least one contact group includes a pair of first contacts and eight second contacts. The pair of first contacts is a pair of differential signal contacts. The second contacts are arranged around the pair of first contacts. Two of the second contacts are arranged along a straight line perpendicular to a connecting line of the pair of first contacts. The position distribution and electrical properties of the other six of the second contacts are symmetrical to each other relative to the straight line. 1. A contact arrangement , comprising:{'claim-text': ['a pair of first contacts, as a pair of differential signal contacts; and', 'eight second contacts, arranged around the pair of first contacts, wherein two of the plurality of second contacts are arranged along a straight line perpendicular to a connecting line of the pair of first contacts, and position distribution and electrical properties of the other six of the plurality of second contacts are symmetrical to each other relative to the straight line.'], '#text': 'a plurality of contacts, being staggered, wherein a plurality of the plurality of contacts form at least one contact group, and the at least one contact group comprises:'}2. The contact arrangement according to claim 1 , wherein one of the pair of first contacts is equidistant from the surrounding plurality of second contacts and the other one of the pair of first contacts.3. The contact arrangement according to claim 1 , wherein a number of the plurality of second contacts as power contacts around one of the pair of first contacts is the same as the number of the plurality of second contacts as power contacts around the other one of the pair of first contacts claim 1 , and a number of the plurality of second contacts as ground contacts around one of the pair of first contacts is the same as the number of ...

JANUS KINASE INHIBITORS AND USES THEREOF

The present invention provides kinase inhibitors, such as compounds of Formula (I) and Formula (II). The compounds may covalently or non-covalently bind a kinase (e.g., Janus kinase 3 (JAK3)). Also provided are pharmaceutical compositions, kits, methods, and uses that involve the compounds for reducing the activity of a kinase and/or treating and/or preventing a condition associated with aberrant activity of a kinase (e.g., a proliferative disease, inflammatory disorder, autoimmune disorder, painful condition, and/or viral infection). (I) (II) 326-. (canceled)3436-. (canceled)39. (canceled)4150-. (canceled)52. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable excipient.53. A method of reducing the activity of a kinase in a subject in need thereof claim 1 , the method comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , in an amount sufficient to reduce the activity of the kinase.54. A method of treating a condition associated with aberrant activity of a kinase in a subject in need thereof claim 1 , the method comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , in an amount sufficient to treat the condition.5563-. (canceled)64. The method of claim 54 , wherein the condition is a proliferative disease claim 54 , inflammatory disorder claim 54 , autoimmune disorder claim 54 , painful condition claim 54 , or viral infection.65. A kit comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a compound of , or a pharmaceutically acceptable salt thereof; and'}instructions for using the kit. The present application claims priority under 35 U.S.C. §119(e) to U.S. provisional patent application, 61/983,175, filed Apr. 23, 2014, which is incorporated herein by reference.Kinase inhibitors are rapidly becoming one of the most validated and ...

FORMULATION OF AN ORGANIC FUNCTIONAL MATERIAL

The present invention relates to formulations containing at least one organic functional material and at least a first organic solvent, wherein said first organic solvent contains at least one norbornene group as well as to electronic devices prepared by using these formulations. 123.-. (canceled)24. A formulation comprising at least one organic functional material and at least a first organic solvent , wherein said first organic solvent contains at least one norbornene group.26. The formulation according to claim 24 , wherein the first organic solvent claim 24 , which contains at least one norbornene group claim 24 , is a solvent according to general formula (I) claim 24 , wherein{'sup': 1', '2', '3, 'R, Rand Rare H;'}{'sub': '2', 'claim-text': {'sup': 5', '5, '—NR—, —CONR—, —O—CO—, —CO—O—, —C═O—, —CH═CH— or —C≡C—;'}, 'Sp is a straight-chain alkyl group having from 1 to 20 carbon atoms or a branched alkyl group having from 3 to 20 in which one or more non-adjacent CHgroups may be replaced by —O—, —S—,'}{'sup': 4', '5, 'Ris H, or a mono- or polycyclic, alicyclic or heterocyclic ring system, which has from 3 to 14 ring atoms, a mono- or polycyclic aromatic ring system, which has from 6 to 14 ring atoms, or a mono- or polycyclic heteroaromatic ring system, which has from 5 to 14 ring atoms, each of these ring systems may be substituted by one or more nonaromatic Rradicals;'}{'sup': 5', '5, 'sub': '2', 'Rare identical or different at each instance, and are a straight-chain alkyl or alkoxy group having from 1 to 20 carbon atoms or a branched or cyclic alkyl or alkoxy group having from 3 to 20 carbon atoms, in which one or more non-adjacent CHgroups may be replaced by —O—, —S—, —CO—O—, —C═O—, —CH═CH— or —C≡C—, and in which one or more hydrogen atoms may be replaced by F, or an aryl or heteroaryl group which has from 4 to 14 carbon atoms and may be substituted by one or more nonaromatic Rradicals.'}27. The formulation according to claim 24 , wherein the first organic ...

HEAT SINK MODULE AND MANUFACTURING METHOD THEREOF

In a heat sink module and a manufacturing method thereof, the method includes steps of: forming a heat dissipation fin set by aluminum extrusion process, wherein the heat dissipation fin set includes a plate, a plurality of fins extending from one side of the plate and being arranged spaced apart from one another, and a joint portion formed on the other side of the plate; placing the plate in a mold; injecting molten metal into the mold; forming a base by die-casting of the molten metal. The plate and the joint portion are wrapped by the base. The joint portion forms a connection structure including a bump and a notch fitted with the bump, so as to connect and fix the base and the heat dissipation fin set. The heat sink module has the strengthened connection structure and the fins with a superior aspect ratio. 1. A heat sink module , comprising:a base;a heat dissipation fin set connected to the base and comprising:a plate; anda plurality of fins, each of the fins extending from one side of the plate to be away from the base and being arranged spaced apart from one another; anda connection structure disposed between the plate and the base for fixing the base and the heat dissipation fin set,wherein the connection structure includes at least one bump and at least one groove fitted with the bump.2. The heat sink module of claim 1 , wherein the bump is a trapezoidal block gradually widening as it protrudes from a surface of the plate toward the base claim 1 , and the groove is a trapezoidal notch denting from a surface of the base.3. The heat sink module of claim 2 , wherein the bump includes a connection depth claim 2 , the connection depth is smaller than a plate thickness of the plate.4. The heat sink module of claim 2 , wherein an aspect ratio of the fin is from 10 to 20.5. The heat sink module of claim 2 , wherein the bump extends from one side edge of the plate to another side edge of the plate.6. The heat sink module of claim 5 , wherein the bump extends in a ...

TOUCH SENSOR EXCITATION USING TRANSFORMER

Input device power consumption can be reduced with a magnetic drive system. In some examples, the input device can include a transformer configured to generate a desired high output voltage from logic-level input pulses. In some examples, the distributed capacitance and associated resonance of the transformer can act as a low-pass filter, and can create a relatively clean output waveform from input logic signal waveforms. In some examples, the transformer can be an autotransformer. In some examples, to stabilize an amplitude of the output by sampling the output of the transformer and adjusting the input to the transformer based on the sampled output. 1. An active stylus , comprising:a first electrode at a distal end of the active stylus;a first transformer circuit coupled to the first electrode, the transformer configured as an autotransformer; andcontrol circuitry coupled to the first transformer circuit capable of applying one or more first signals to the first transformer circuit to generate one or more second signals at the first electrode.2. The active stylus of claim 1 , further comprising:a second electrode at the distal end of the active stylus; anda second transformer circuit coupled to the second electrode and coupled to the control circuitry;wherein the control circuitry is further capable of applying one or more third signals to the second transformer circuit to generate one or more fourth signals at the second electrode.3. The active stylus of claim 1 , wherein the one or more first signals comprise a first logic signal applied to a first tap of the first transformer circuit and a second logic signal applied to a second tap of the first transformer circuit.4. The active stylus of claim 3 , wherein the first logic signal and second logic signal are tuned to reduce power consumption of the active stylus.5. The active stylus of claim 1 , wherein the control circuitry is further capable of adjusting a voltage characteristic of the one or more first signals ...

Selective indication of off-screen object presence

Systems, methods, and media are provided for the selective indication of the presence of off-screen objects in the shared gaming environment of a multiplayer game played on a mobile device. The shared gaming environment can include a game space and a plurality of objects located at various places of the game space. The player may view a portion of the game space via a screen view presented by the mobile device. The screen view can be bordered by a frame area that includes a portion of the game space that is outside of the screen view. Based on a predetermined rule set, the presence of an object that is located within the frame area can be selectively indicated within the screen view by a visual indicator, such as an icon. The visual indicator can be assembled from a library of elements to visually communicate contextually relevant information to the player.

HEAT DISSIPATION ASSEMBLY

A heat dissipation assembly includes a condenser, an evaporator, a vapor conduit, and a liquid conduit. The condenser has a condensing chamber therein. Two ends of the vapor conduit are respectively connected to the condenser and the evaporator. Two ends of the liquid conduit are respectively connected to the condenser and the evaporator. A geometric center of the liquid conduit in the condensing chamber is lower than or equal to a geometric center of the condensing chamber. 1. A heat dissipation assembly , comprising:a condenser having a condensing chamber therein;an evaporator;a vapor conduit, wherein two ends of the vapor conduit are respectively connected to the condenser and the evaporator; anda liquid conduit, wherein two ends of the liquid conduit are respectively connected to the condenser and the evaporator,wherein a geometric center of the liquid conduit in the condensing chamber is lower than or equal to a geometric center of the condensing chamber.2. The heat dissipation assembly of claim 1 , wherein the evaporator has an evaporating chamber claim 1 , and a geometric center of the liquid conduit in the evaporating chamber is lower than or equal to a geometric center of the evaporating chamber.3. The heat dissipation assembly of claim 2 , wherein the evaporating chamber has a first portion and a second portion that communicates with the first portion claim 2 , and the first portion is located at an edge of the second portion.4. The heat dissipation assembly of claim 2 , wherein the liquid conduit has a water outlet in the evaporating chamber claim 2 , and the evaporator comprises:a liquid working fluid, wherein the water outlet of the liquid conduit is lower than a liquid level of the liquid working fluid.5. The heat dissipation assembly of claim 4 , wherein the water outlet of the liquid conduit rotates along an axis of the liquid conduit.6. The heat dissipation assembly of claim 5 , wherein the water outlet rotates from a horizontal direction to an ...

Active stylus ring electrode

A ring electrode to determine the orientation of the stylus relative to the surface. The stylus can include a ring electrode configuration which can improve capacitive coupling between the ring electrode and the touch panel. The ring electrode configuration can include a ring electrode and ground ring, and ground plate. By varying the lengths of ring electrode, ground ring, ground plate, and the distance between these elements, the electric field emanating from the ring electrode can be tuned to optimize the capacitive coupling between the ring electrode and surface. In some examples, the ring electrode can include multiple sub-rings. In some examples, the ring electrode can comprise a crown shape including projections, each having a width that tapers to a minimum width along the length of the ring electrode.

ACTIVE STYLUS PRECISION TIP

An electrode for an input device can be designed to reduce wobble over a range of input device orientations. The electrode can include a spherical portion and a tapered portion. In some examples, the electrode can linearly taper away from the spherical portion. In other examples, the electrode can non-linearly taper away forming an elliptical flare. Additionally or alternatively, the electrode can include a spring-loaded member that can couple the electrode to other circuitry of the input device. Additionally or alternatively, the electrode can include a neck portion coupled to the tapered portion, and part of the neck portion can be shielded. The input device can include a first non-conductive material disposed on part of the spherical portion of the electrode and a second non-conductive material disposed between part of the electrode and the first non-conductive material. 1. An electrode for an active stylus , comprising:a spherical portion; anda spring-loaded contact member configured to couple the electrode to stimulation circuitry.2. The electrode of claim 1 , further comprising:a tapered portion in which the electrode linearly tapers away from the spherical portion toward the spring-loaded contact member.3. The electrode of claim 1 , further comprising:a tapered portion in which the electrode tapers away from the spherical portion toward the spring-loaded contact member forming an elliptical flare.4. The electrode of claim 1 , further comprising a neck portion claim 1 , wherein the spring-loaded contact member extends from the neck portion.5. The electrode of claim 1 , wherein the spring-loaded contact member extends from the spherical portion.6. A removable tip portion for an input device claim 1 , the tip portion comprising:an electrode including a spherical portion facing a tip of the removable tip portion and a tapered portion in which the electrode tapers away from the tip of the removable tip portion;a first non-conductive material disposed on at least ...

SYSTEM AND METHOD FOR MANAGING SPACE IN STORAGE OBJECT STRUCTURES

System and method for managing space in storage object structures stored in a storage system uses an object B tree structure to manage a storage object in a storage object structure in the storage system, which provides virtual physical block addresses for data of the storage object and for metadata of nodes of the object B tree structure. The metadata of the nodes of the object B tree structure is written in the storage object structure using first real physical block addresses, which are translated from the virtual block addresses for the metadata of the nodes of the object B tree structure using a metadata system file B tree structure. The data of the storage object is written in the storage object structure using second real physical block addresses, which are translated from the virtual block addresses for the data of the storage object using a data system file B tree structure. 1. A method for managing space in storage object structures stored in a storage system , the method comprising:using an object B tree structure to manage a storage object in a storage object structure in the storage system, the object B tree structure providing virtual physical block addresses for data of the storage object and for metadata of nodes of the object B tree structure;writing the metadata of the nodes of the object B tree structure in the storage object structure using first real physical block addresses, wherein the first real physical block addresses are translated from the virtual physical block addresses for the metadata of the nodes of the object B tree structure using a metadata system file B tree structure; andwriting the data of the storage object in the storage object structure using second real physical block addresses, wherein the second real physical block addresses are translated from the virtual physical block addresses for the data of the storage object using a data system file B tree structure.2. The method of claim 1 , further comprising using the virtual ...

PLANARIZATION LAYER FOR ORGANIC ELECTRONIC DEVICES

The invention relates to organic electronic devices containing polycycloolefin planarization layers between the substrate and a functional layer such as a semiconducting layer, dielectric layer, or electrode; to the use of polycycloolefins as a planarization layer on the substrate of an organic electronic device; and to processes for preparing such polycycloolefin planarization layers and organic electronic devices. 1. An organic electronic device comprising a substrate having a planarization layer disposed directly on the substrate , and provided on said substrate a functional layer selected from semiconducting layers , dielectric layers , and electrodes , wherein the planarization layer is positioned between the substrate and the functional layer , wherein said planarization layer comprises a polycycloolefinic polymer.2. The organic electronic device of claim 1 , wherein the polycycloolefinic polymer is a norbornene-type polymer.3. The organic electronic device of claim 1 , wherein the polycycloolefinic polymer comprises two or more distinct types of repeating units.4. The organic electronic device of claim 3 , wherein one of the two or more distinct repeating units includes a pendant crosslinkable group.5. The organic electronic device of claim 4 , wherein the pendant crosslinkable group is a latent crosslinkable group.6. The organic electronic device of claim 5 , wherein the pendant crosslinkable group comprises a substituted or unsubstituted maleimide portion claim 5 , an epoxide portion claim 5 , a vinyl portion claim 5 , an acetylene portion claim 5 , an indenyl portion claim 5 , a cinnamate portion or a coumarin portion.8. The organic electronic device of claim 4 , wherein the polycycloolefinic polymer comprises a second type of repeating unit having a pendant silyl group.14. The organic electronic device of claim 1 , wherein the planarization layer is derived from a polymer composition claim 1 , said composition comprising one or more of a solvent claim 1 , ...

QUINOLINE OR QUINAZOLINE COMPOUND AND APPLICATION THEREOF

The present invention relates to quinoline or quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals. 2. The quinoline or quinazoline compound of or a pharmaceutically acceptable salt thereof claim 1 , a stereoisomer thereof claim 1 , a prodrug molecule thereof claim 1 , or a deuterated analog thereof claim 1 , wherein Rand Rare each independently —O(CRR)R;{'sub': 3', '4', '5', '1', '6', '8', '8', '9, 'R, Rand Rare each independently selected from a group consisting of —H, C˜Calkyl, —ORand —NRR;'}{'sub': 8', '9', '1', '6', '8', '9', '10', '10', '1', '6, 'Rand Rare each independently selected from a group consisting of C˜Calkyl, or, Rand Rtogether with N connected thereto form a saturated or unsaturated 5- to 8-membered heterocyclic group; wherein, the saturated or unsaturated 5- to 8-membered heterocyclic group can be independently and optionally substituted with one or more R; wherein Ris selected from a group consisting of C˜Calkyl.'}3. The quinoline or quinazoline compound of or a pharmaceutically acceptable salt thereof claim 2 , a stereoisomer thereof claim 2 , a prodrug molecule thereof claim 2 , or a deuterated analog thereof claim 2 , wherein Ris —O(CH)R;{'sub': 3', '1', '6', '1', '3', '8', '9, 'o is an integer from 0 to 4; Ris selected from a group consisting of —H, C˜Calkyl, C˜Calkoxy and —NRR;'}{'sub': 8', '9', '1', '3', '8', '9', '10', '10', '1', '3, 'Rand Rare each ...

WATER COOLING DEVICE AND COLLECTOR THEREOF

A water cooling device includes a first collector, a second collector and a plurality of tubes. The first collector includes a receiving chamber and a plurality of distribution chamber. The receiving chamber has an inlet for receiving a working fluid. Each of the distribution chambers includes a first wall portion and a second wall portion opposite to the first wall portion. The first wall portion has an opening communicating with the receiving chamber. The second wall portion has an outlet. Each of the tubes is connected to the outlet of one of the distribution chambers on one end, and is connected to the second collector on another end. 1. A water cooling device , comprising:{'claim-text': ['a receiving chamber having an inlet for receiving a working fluid; and', 'a plurality of distribution chambers, each comprising a first wall portion and a second wall portion, the second wall portion being opposite to the first wall portion, wherein the first wall portion has an opening communicating with the receiving chamber, and the second wall portion has an outlet;'], '#text': 'a first collector, comprising:'}a second collector; anda plurality of first tubes, each connected to the outlet of one of the distribution chambers on one end, and connected to the second collector on another end.2. The water cooling device of claim 1 , wherein a size of the opening is positively correlated with a distance from the opening to the inlet of the receiving chamber.3. The water cooling device of claim 1 , wherein at least one of the distribution chambers further comprises a duct claim 1 , and the duct protrudes from the first wall portion towards the second wall portion.4. The water cooling device of claim 3 , wherein the number of the distribution chamber with the duct is two or more than two claim 3 , and two of the ducts have differing diameters claim 3 , cross-sectional areas claim 3 , lengths or inner surface roughness.5. The water cooling device of claim 1 , wherein the receiving ...

DEVICE SYNCHRONIZATION OVER BLUETOOTH

Time synchronization between a central wireless communication device and a peripheral wireless communication device is described. Events associated with an application are time stamped at the central wireless communication device, and one or more link layer messages are sent to the peripheral wireless communication device to provide time stamp information to replicate the event timing at the peripheral wireless communication device. A first link layer message includes information about an internal Bluetooth clock to calibrate a corresponding internal clock value at the peripheral wireless communication device. A second link layer message includes information about a current value for the Bluetooth clock and also a value for an offset that provides a time position at a finer granularity than the Bluetooth clock within a timeslot specified by the Bluetooth clock value. Application layer event synchronization between the central and peripheral wireless communication devices allow for power reduced dormant states between events. 1. A method for providing time synchronization over a low power connection between a central wireless communication device and a peripheral wireless communication device , the method comprising: establishing a connection to the peripheral wireless communication device;', 'obtaining an indication that the peripheral wireless communication device supports time synchronization;', 'providing a clock indication message to the peripheral wireless communication device, the clock indication message including a first clock value for a clock associated with wireless circuitry of the central wireless communication device;', 'obtaining an acknowledgement of the clock indication message from the peripheral wireless communication device; and', 'in response to an application layer event at the central wireless communication device, providing a sync indication message to the peripheral wireless communication device, the sync indication message including a ...

ESTERS CONTAINING AROMATIC GROUPS AS SOLVENTS FOR ORGANIC ELECTRONIC FORMULATIONS

The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise (A) at least one specific ester solvent containing an aromatic group and (B) at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earth metals, lanthanides and actinides. 141.-. (canceled)44. The formulation according to claim 42 ,{'sup': ['4', '5'], 'sub': '3', '#text': 'wherein Ron each occasion is selected independently from the group consisting of hydrogen, straight-chain alkyl or alkoxy groups having from 1 to 6 carbon atoms, straight-chain alkenyl or alkynyl groups having from 2 to 6 carbon atoms, branched-chain alkyl, alkoxy or alkenyl groups having from 3 to 6 carbon atoms, branched-chain alkynyl groups having from 4 to 6 carbon atoms and SiR,'}{'sup': '5', '#text': 'wherein Ron each occasion is selected independently from the group consisting of hydrogen, straight-chain alkyl or alkoxy groups having from 1 to 6 carbon atoms and branched-chain alkyl or alkoxy groups having from 3 to 6 carbon atoms.'}46. The formulation according to claim 42 ,{'sup': ['1', '3', '2', '3', '3'], '#text': 'wherein Ris H or R; Ris H or R; and Ron each occasion is selected independently from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl and their isomers; or'}{'sup': ['1', '2', '3'], 'sub': '2', '#text': 'wherein Rand Rtaken together represent ═CH; and Ris selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl and their isomers.'}47. The formulation according to claim 46 ,{'sup': ['1', '3', '2', '3', '3'], '#text': ' ...

System and method for managing timeseries data

There is described a system and method for managing timeseries data. A timeseries consumer receives timeseries data from multiple devices, provides the timeseries data to a particular partition of a data table based on an insert time of the timeseries data to the data table, and records metadata associated with the timeseries data provided to the particular partition at a track table. A timeseries archiver identifies recent records of the data table based on insert time(s) and archival time(s) of a milestone table, archives the timeseries data of the data table associated with the recent records to an external system, and updates the archival time(s) of the milestone table and the track table. The timeseries purger drops an archived partition of the data table based on determining that all records of the archived partition have been archived.

DETERMINING A RATE FOR SAMPLING INFORMATION DESCRIBING PRESENTATION OF CONTENT BASED ON PREVIOUSLY RECEIVED INFORMATION DESCRIBING PRESENTATION OF CONTENT

An online system logs information describing presentation of content items, such as actions performed with presented content items or descriptions of presentation of content items, and uses the logged information to recommend other content items. Because of a large amount of information describing content item presentation, the online system samples the information and stores the resulting samples. To improve accuracy of the sampling, the online system adapts the sampling rate for different types of information describing presentation of content items based on amounts of the different types of information received during a specific time interval. 1. A method comprising:transmitting descriptions of recommended actions selected by an online system to client devices associated with users of the online system, each recommended action for presentation via one or more channels;receiving information, at the online system, from one or more client devices identifying a description of a recommended action, a channel used to present the recommended action, and an action with the recommended action;retrieving information stored by the online system identifying a number of times the content item was presented by each of one or more channels during a specific time interval;determining a sampling rate for each of the one or more channels based on the number of times the content item was presented by each of one or more channels during the specific time interval;sampling the received information describing presentation of the description of the recommended action by each of one or more channels, information describing presentation of the description of the recommended action by the channel sampled at the sampling rate determined for the channel; andstoring the sampled information describing presentation of the description of the recommended action by each of the one or more channels at the online system.2. The method of claim 1 , wherein the sampling rate determined for the channel ...

Method and apparatus for calculating soc of a battery being charged and battery pack including the apparatus

A method and an apparatus for calculating the SOC of a battery being charged and a battery pack including the apparatus are disclosed in the present disclosure. The method for calculating the SOC includes: obtaining a full charge voltage and a reference charging voltage curve of the battery; taking a voltage value from the approximately linear ascent stage of the reference charging voltage curve as a preset reference voltage, and obtaining a corresponding reference SOC; acquiring a current charging voltage at which a charging voltage curve corresponding to a current charging state of the battery enters into an approximately linear ascent stage; determining a compensation factor according to the preset reference voltage, the full charge voltage, and the current charging voltage; and utilizing the compensation factor and the reference SOC to calculate a current SOC corresponding to the current charging state of the battery.

ORGANIC SEMICONDUCTORS

The invention relates to novel organic semiconducting (OSC) random copolymers containing a halo-substituted 4,8-dithiophenyl-benzodithiophene unit and a benzodithiophene-dione unit, to methods for their preparation and educts or intermediates used therein, to compositions and formulations containing them, to the use of the copolymers and compositions as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, perovskite-based solar cell (PSC) devices, organic photodetectors (OPD), organic field effect transistors (OFET) and organic light emitting diodes (OLED), and to OE devices comprising these copolymers or compositions. 2. The conjugated polymer according to claim 1 , characterized in that in the units of formula I Rand Rare selected from the group consisting of straight-chain or branched alkyl claim 1 , alkoxy or thioalkyl having 1 to 30 C atoms and being optionally fluorinated.9. A composition comprising a conjugated polymer according to and one or more additional compounds having one or more of semiconducting claim 1 , charge transport claim 1 , hole or electron transport claim 1 , hole or electron blocking claim 1 , electrically conducting claim 1 , photoconducting or light emitting properties.10. The composition of claim 9 , further comprising one or more p-type semiconductors claim 9 , and one or more n-type semiconductors.11. The composition of claim 10 , wherein the composition comprising one or more n-type semiconductors selected from small molecules that do not contain a fullerene moiety.12. A bulk heterojunction (BHJ) formed from a composition according to .13. A formulation comprising a conjugated polymer according to claim 1 , and further comprising one or more organic solvents.14. Use of a conjugated polymer according to claim 1 , in an electronic or optoelectronic device claim 1 , or in a component of such a device or in an assembly comprising such a device.15. An ...

SYSTEMS AND METHODS FOR PROVIDING IMAGE PERSPECTIVE ADJUSTMENT AND AUTOMATIC FITTING

Systems, methods, and non-transitory computer-readable media can provide one or more options to adjust, in a virtual three-dimensional space, an image in an initial perspective. At least a first command, provided based on the one or more options, to adjust the image from the initial perspective into an adjusted perspective can be detected. The image can be adjusted, based on at least the first command, into the adjusted perspective in the virtual three-dimensional space to produce an adjusted image. A second command to modify a viewable area of the adjusted image can be detected. At least a portion of the adjusted image can be automatically fitted, when the second command has ceased, within a specified display area while one or more empty regions can be minimized in the specified display area. 1. A computer-implemented method comprising:providing, by a computing system, one or more options to adjust, in a virtual three-dimensional space, a two-dimensional image in an initial perspective, wherein the one or more options to adjust the image include at least one of a first option to adjust the image with respect to a horizontal axis in the virtual three-dimensional space, a second option to adjust the image with respect to a vertical axis in the virtual three-dimensional space, or a third option to adjust the image with respect to a depth axis in the virtual three-dimensional space;detecting, by the computing system, at least a first command, provided based on the one or more options, to adjust the image from the initial perspective into an adjusted perspective;adjusting, by the computing system, based on at least the first command, the image into the adjusted perspective in the virtual three-dimensional space to produce an adjusted image;providing, by the computing system, the adjusted image in a specified display area of a computing device;detecting, by the computing system, a second command to modify a viewable area of the adjusted image within the specified display ...

PROMOTING EFFICIENT CELL USAGE TO BOOST QOR IN AUTOMATED DESIGN

A method of designing integrated circuits includes forming a restricted cell library from a first cell library by selecting only those cells in the first cell library that are most efficient according to predetermined efficiency criteria and executing an integrated circuit design operation in an electronic design automation program while directing the electronic design automation program to make cell selections exclusively from the restricted cell library. The integrated circuit design operation is one that can be directed to make cell selections from any of the cells in the first cell library without changing its essential purpose. The method improves QoR for the resulting circuit design. 15-. (canceled)6. A method of designing an integrated circuit , comprising:forming a first restricted cell library from a first cell library by selecting only those cells in the first cell library that are most efficient according to a first predetermined efficiency criteria; andexecuting an integrated circuit design operation in an electronic design automation program while directing the electronic design automation program to make cell selections exclusively from the first restricted cell library;wherein the integrated circuit design operation is selectively configured to make the cell selections from any of the cells in the first restricted cell library during its execution.7. The method of claim 6 , further comprising executing an incremental optimization of the integrated circuit design operation in the electronic design automation program while directing the electronic design automation program to make cell selections directly from the first cell library.8. The method of claim 6 , further comprising:determining that a circuit design that results from executing the integrated circuit design operation in the electronic design automation program is unsatisfactory;forming a second restricted cell library from the first cell library by selecting only those cells in the first cell ...

THERMOSYPHON HEAT SINK

A heat-dissipating device includes a condenser and an evaporator. The condenser includes a shell and a main capillary wick. The shell has a chamber and a through hole communicating with the chamber. The main capillary wick is disposed in the chamber. The evaporator has an evaporating section, a gas conduit and a liquid conduit. The evaporating section has a gas cavity, and the liquid conduit communicating with the chamber and filling with a liquid. The liquid conduit having a hole communicating with the gas cavity is inserted in the gas conduit and the gas cavity. A stepped area is formed between the liquid conduit and the chamber for gathering the liquid flowing into the liquid conduit. 1. A heat-dissipating device for contacting with a heating element , comprising:a condenser comprising a shell having a chamber and a through hole communicating with the chamber, and a main capillary wick disposed in the chamber; andan evaporator comprising an evaporating section having a gas cavity, a gas conduit communicating with the through hole, and a liquid conduit communicating with the chamber and filling with liquid, wherein the liquid conduit is inserted in the gas conduit and has a hole communicating with the gas cavity, and an outer surface of the evaporating section is contacted with the heating element;wherein a stepped area is formed at a location where the liquid conduit is assembled with the chamber, the liquid flows in the gas cavity and absorbs the heat generated from the heating element to be transformed into gas and flows in the chamber through the gas conduit, the gas is transformed into the liquid, gathered in the stepped area by cooling of the condenser and flows into the liquid conduit.2. The heat-dissipating device according to claim 1 , wherein the evaporator further comprises an auxiliary evaporating section at a side of the evaporating section away from the condenser claim 1 , the evaporating section and the auxiliary evaporating section are arranged in ...

FORMULATION AND METHOD FOR PREPARATION OF ORGANIC ELECTRONIC DEVICES

The present invention relates to novel formulations comprising an organic semiconductor (OSC) and one or more organic solvents. The formulation comprises a viscosity at 25° C. of less than 15 mPas and the boiling point of the solvent is at most 400° C. Furthermore, the present invention describes the use of these formulations as inks for the preparation of organic electronic (OE) devices, especially organic photovoltaic (OPV) cells and OLED devices, to methods for preparing OE devices using the novel formulations, and to OE devices, OLED devices and OPV cells prepared from such methods and formulations. 1. Formulation comprising one or more organic semiconducting compounds (OSC) , and one or more organic solvents , characterized in that said formulation comprises a viscosity at 25° C. of less than 15 mPas and the boiling point of the solvent is at most 400° C.2. Formulation according to claim 1 , characterized in that said formulation comprises a viscosity at 25° C. in the range of 0.5 to 9.5 mPas.3. Formulation according to claim 1 , characterized in that said formulation is a solution.4. Formulation according to claim 1 , characterized in that said formulation comprises a surface tension in the range of 22 mN/m to 50 mN/m.5. Formulation according to claim 1 , characterized in that said organic solvent comprises Hansen Solubility parameters of Hin the range of 17.0 to 23.2 MPa claim 1 , Hin the range of 0.2 to 12.5 MPaand Hin the range of 0.0 to 20.0 MPa.6. Formulation according to claim 5 , characterized in that said organic solvent comprises Hansen Solubility parameters of Hin the range of 17.0 to 23.2 MPa claim 5 , Hin the range of 0.2 to 10.5 MPaand Hin the range of 0.0 to 5.0 MPa.7. Formulation according to claim 1 , characterized in that said organic solvent comprises one or more of an aromatic and/or heteroaromatic compound.8. Formulation according to claim 7 , characterized in that said organic solvent comprises of one or more aromatic hydrocarbon compound. ...

Systems and Methods for Collecting and Accruing Labor Activity Data Under Many-to-Many Employment Relation and with Distributed Access

A system and methods enable distributed users to have controlled and distributed access to labor data, and the labor data are produced as the results of monitoring and accruing labor activities with many-to-many employment relation. One method further comprises: (1) a method of importing data as the result of monitoring labor activities, and resolving the employment relation under which a labor activity is performed; (2) a method of accruing labor activities using input data according to the employment relation identified by method (1), and; (3) a method of enabling controlled access to labor and payroll data for distributed users. Labor monitoring software system (a) accrues labor activities from field-collected labor monitoring data, (b) identifies the employment relation, and (c) prepares payroll report based on the terms defined in the employment relation. Authorized users may access the data in raw or processed format from a variety of Internet-connected devices, including smartphones, tablets, and desktop computers. The system may be used in a variety of applications in which an employee has multiple employers, and distributed access to labor data is needed. 1. A labor monitoring and payroll accounting method comprising the steps of:using a system comprising one or more servers configured to register users, wherein users are employers, employees, and their trusted agents, registration including employment relations between employers and employees and additional information that facilitates payroll computation and other functions of the system;assigning by an employer one or more local identification records (LIRs) to each of his/her employees, an employee's LIR uniquely identifying an employee for a given employer at an instant of time;using a labor monitoring device (LMD) to monitor actual labor activities of an employee, the LMD containing one or more Device Identification Records (DIRs);{'sub': R', 'R', 'R', 'R', 'R', 'R′', 'R', 'R′, 'sup': 'l', ' ...

AMOLED DISPLAY DEVICE

The present disclosure provides an AMOLED display device, which comprises a main control processor, a driving integrated chip (IC), a power management chip, and a pulse control line. The power management chip generates a voltage signal, after receiving the digital signal. The power management chip comprises an identification (ID) generation module. The ID generation module comprises a control protocol of the power management chip. The ID generation module is configured to generate an ID signal of the power management chip according to the control protocol of the power management chip. 1. An active matrix organic light-emitting diode (AMOLED) display device , comprising: a main control processor , a driving integrated chip (IC) , a power management chip , and a pulse control line;the main control processor internally storing at least three protocol control tables, the main control processor configured to send a control signal to the driving IC, to instruct the driving IC to regulate signal voltage of the power management chip;the driving IC is connected with the power management chip through the pulse control line and configured to send a digital signal to the power management chip after receiving the control signal sent by the main control processor;the power management chip generating a voltage signal after receiving the digital signal, the voltage signal comprising a driving voltage of a thin film transistor and a driving voltage of an organic light emitting device;the power management chip comprising an identification (ID) generation module, the ID generation module comprising a control protocol of the power management chip, and the ID generation module configured to generate an ID signal of the power management chip according to the control protocol of the power management chip;wherein the control protocol corresponds to a pulse number of the digital signal and a voltage value of the voltage signal.2. The AMOLED display device according to claim 1 , wherein the ...

MULTISTAGE ANALYSIS OF EMAILS TO IDENTIFY SECURITY THREATS

Conventional email filtering services are not suitable for recognizing sophisticated malicious emails, and therefore may allow sophisticated malicious emails to reach inboxes by mistake. Introduced here are threat detection platforms designed to take an integrative approach to detecting security threats. For example, after receiving input indicative of an approval from an individual to access past email received by employees of an enterprise, a threat detection platform can download past emails to build a machine learning (ML) model that understands the norms of communication with internal contacts (e.g., other employees) and/or external contacts (e.g., vendors). By applying the ML model to incoming email, the threat detection platform can identify security threats in real time in a targeted manner. 1. A system , comprising: receive input indicative of an approval to access emails delivered to an employee of an enterprise;', 'acquire an incoming email addressed to the employee;', 'extract a primary attribute from the incoming email by parsing content of the incoming email and/or metadata associated with the incoming email;', 'derive a secondary attribute based on the primary attribute; and', 'determine whether the incoming email deviates from past email activity by comparing the primary and secondary attributes to a communication profile associated with the employee; and, 'a processor configured toa memory coupled to the processor and configured to provide the processor with instructions.2. The system of claim 1 , wherein the processor is further configured to establish claim 1 , via an application programming interface claim 1 , a connection with an email system employed by the enterprise.3. The system of claim 1 , wherein the communication profile includes primary and secondary attributes of past emails delivered to the employee determined to be representative of safe communications.4. The system of claim 3 , wherein said determining includes discovering whether ...

HYDROGEL MICROPHONE

A device includes a capacitive sensor having a hydrogel structure that includes a first surface and a second surface. A first electrode is provided at the first surface of the hydrogel structure, the first electrode including a network of conductive nanoparticles extending into the hydrogel structure. A second electrode is provided at the second surface of the hydrogel structure. 1. A device comprising: a hydrogel structure comprising a first surface and a second surface;', 'a first electrode at the first surface of the hydrogel structure, the first electrode comprising a network of conductive particles extending into the hydrogel structure; and', 'a second electrode at the second surface of the hydrogel structure., 'a capacitive sensor comprising2. The device of claim 1 , wherein the hydrogel structure comprises a cross-linked and hydrophilic polymer.3. The device of in which the network of conductive particles comprises a network of conductive nanoparticles.4. The device of in which the network of conductive nanoparticles is deformable in response to changes in the hydrogel structure.5. The device of in which the network of conductive nanoparticles comprises at least one of tree-like or dentritic structures that have branches claim 3 , and electric double layers are formed between the branches.6. The device of in which the capacitive sensor has electric double layer capacitances that change as the network of conductive nanoparticles is deformed due to a change in the hydrogel structure.7. The device of claim 3 , wherein the first surface and the second surface of the hydrogel structure define a thickness between 0.1 mm and 5 mm.8. The device of claim 3 , wherein the first electrode comprises a terminal positioned on and extending along the first surface of the hydrogel structure claim 3 , the terminal being electrically coupled to the network of conductive nanoparticles.9. The device of claim 8 , wherein the terminal comprises copper.10. The device of claim 3 , ...

ORGANIC ELECTRONIC DEVICE COMPRISING AN ORGANIC SEMICONDUCTORS FORMULATION

The invention generally relates to organic semiconductor formulations for use in organic semiconductor layers of organic electronic devices, and more specifically in organic field effect transistors, to organic semiconductor layers prepared from such formulations, and to organic electronic devices and organic field effect transistors encompassing such organic semiconductor layers. 5. The organic electronic device according to claim 1 , wherein the organic binder is selected from co-polymers comprising one or more units of formula 1 or its subformulae 1a-c claim 1 , and further comprising one or more additional units selected from arylene and heteroarylene units that are optionally substituted.7. The organic electronic device according to claim 1 , wherein the organic binder is selected from co-polymers comprising one or more units of formula 2 and one or more co-units selected from arylene and heteroarylene units that are optionally substituted.8. The organic electronic device according to claim 1 , wherein the organic binder is selected from polymers comprising one or more units of formula 3 and optionally comprising one or more co-units selected from arylene and heteroarylene units that are optionally substituted.11. The organic electronic device according to claim 1 , wherein the organic binder is selected from co-polymers comprising one or more repeating units selected from one of formulae 1 claim 1 , 2 and 3 claim 1 , and one or more repeating units selected from another one of formulae 1 claim 1 , 2 and 3.13. The organic electronic device according to claim 1 , wherein R is alkyl with 1 to 5 C atoms claim 1 , and Rand Rdenote claim 1 , independently of each other claim 1 , straight-chain or branched alkyl with 1 to 20 C atoms claim 1 , or aryl with 5 to 12 C atoms that is optionally substituted with Calkyl or Calkoxy.14. The organic electronic device according to claim 1 , wherein the organic semiconductor comprises a small molecule.15. The organic electronic ...

LIVE-WORKING ROBOT

The present invention discloses a live-working robot, comprising: a telescopic arm and a working hopper, wherein the working hopper and the telescopic arm are slidably connected along a vertical direction and the telescopic arm is provided with the drive component for driving the working hopper to reciprocate along a vertical direction. The live-working robot provided in the present invention achieves a movement of the working hopper along the vertical direction by slidably connecting the working hopper and the telescopic arm along the vertical direction and providing the telescopic arm with the drive component for driving the working hopper to reciprocate along the vertical direction. Since the working hopper is directly and slidably connected with the telescopic arm, there is no need to set a fly jib, which, as compared to the prior art, effectively improves the rigidity and stability of the working arm; which also effectively reduces the length of the working arm, thus reducing the size of the entire live-working robot and reducing the occupied space; and which can meanwhile increase strokes of the working hopper in the vertical direction and thus improve service performance. 1677667. A live-working robot , comprising: a telescopic arm () and a working hopper () , characterized in that said working hopper () and said telescopic arm () are slidably connected along a vertical direction and said telescopic arm () is provided with a drive component for driving said working hopper () to reciprocate along a vertical direction.26768. The live-working robot as recited in claim 1 , characterized in that an end of said telescopic arm () is provided with a slider claim 1 , and a side plate connecting said working hopper () with said telescopic arm () is provided with a slide rail () matching with said slider.3887. The live-working robot as recited in claim 2 , characterized in that it further comprises: a mounting plate perpendicularly connected to said slide rail () claim ...

EFFICIENT GLOBAL CACHE PARTITION AND DYNAMIC SIZING FOR SHARED STORAGE WORKLOADS

A shared cache memory can be logically partitioned among different workloads to provide isolation between workloads and avoid excessive resource contention. Each logical partition is apportioned a share of the cache memory, and is exclusive to a respective one of the workloads. Each partition has an initial size allocation. Historical data can be collected and processed for each partition and used to periodically update its size allocation. 1. A method comprising:a computer system accessing a data object stored on a disk storage system to read data from and write data to the data object;the computer system associating a partition size with the data object, the partition size representing an amount of cache storage in a cache memory for caching read and write operations with the data object;the computer system caching input/output (I/O) operations for reading data from and writing data to the data object, including limiting data associated with the I/O operations that are cached in the cache memory to an amount based on the partition size associated with the data object;the computer system collecting a history of data associated with the data object that have been cached in the cache memory; andthe computer system determining, based on the collected history, a revised partition size and updating the partition size associated with the data object based on the revised partition size,wherein the amount of data that is cached in the cache memory for input/output (I/O) operations on the data object made subsequent to updating the partition size associated with the data object is limited to the updated partition size.2. The method of claim 1 , further comprising evicting data associated with the data object from the cache memory when the amount of data associated with the data object that is cached in the cache memory reaches the partition size associated with the data object.3. The method of claim 1 , further comprising evicting data associated with the data object from ...

ALTERNATING RING-OPENING METATHESIS POLYMERIZATION

The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization. 2. The method of claim 1 , further comprising combining a polymer block comprising repeating units (Ia) claim 1 , (Ib) or (Ic) into a block copolymer.5. The method of claim 3 , wherein L is pyridine or substituted pyridine.6. The method of claim 4 , wherein L is 3-bromopyridyl claim 4 , 3-chloropyridyl or pyridine.7. The method of claim 3 , wherein L′ is an imidazolin-2-ylidine carbene and Ar is selected from the group consisting of phenyl claim 3 , mesityl claim 3 , 2-methylphenyl claim 3 , 2-ethylphenyl claim 3 , 2-i sopropylphenyl claim 3 , 2 claim 3 ,3-diisopropylphenyl claim 3 , 2 claim 3 ,6-difluorophenyl claim 3 , and 3 claim 3 ,5-di-t-butylphenyl.8. The method of or claim 3 , wherein the catalyst is a molybdenum or tungsten metathesis catalyst.10. The polymer of claim 9 , wherein the polymer comprising the repeating unit (Ia) claim 9 , (Ib) or (Ic) is a cyclic polymer.11. The polymer of claim 9 , wherein polymer comprising the repeating unit (Ia) claim 9 , (Ib) or (Ic) is a block in a block copolymer.12. A method of inhibiting microbial growth or inhibiting biofilm formation on a surface comprising the step of contacting one or more microbes with a polymer of .13. A method of preparing a therapeutic agent for delivery to a subject comprising combining the therapeutic agent with a polymer of .14. The method of claim 13 , wherein the therapeutic agent is conjugated to the polymer.15. The method of claim 13 , wherein the therapeutic agent is contained in a micelle comprising the polymer. This application claims priority to U.S. Application No. 61/857,189, filed Jul. 22, 2013, and U.S. Application No. 61/858,811, filed Jul. 26, 2013 ...

ALTERNATING RING-OPENING METATHESIS POLYMERIZATION

The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization. 2. The polymer of claim 1 , wherein the polymer comprising the repeating unit (Ia) claim 1 , (Ib) or (Ic) is a cyclic polymer.3. The polymer of claim 1 , wherein polymer comprising the repeating unit (Ia) claim 1 , (Ib) or (Ic) is a block in a block copolymer.4. A method of inhibiting microbial growth or inhibiting biofilm formation on a surface comprising the step of contacting one or more microbes with a polymer of .5. A method of preparing a therapeutic agent for delivery to a subject comprising combining the therapeutic agent with a polymer of .6. The method of claim 5 , wherein the therapeutic agent is conjugated to the polymer.7. The method of claim 5 , wherein the therapeutic agent is contained in a micelle comprising the polymer. This application is a divisional of U.S. application Ser. No. 14/906,834, filed Jan. 21, 2016, which is a 371 of International patent application number PCT/US2014/047674 filed Jul. 22, 2014; which claims the benefit of priority to U.S. Application No. 61/857,189, filed Jul. 22, 2013, and U.S. Application No. 61/858,811, filed Jul. 26, 2013, which are incorporated herein by reference in their entireties.This invention was made with government support under grant numbers HD038519 and GM097971 awarded by the National Institutes of Health and grant number DBI1039771 awarded by the National Science Foundation. The government has certain rights in the invention.The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization.Copolymers are employed in a wide range of materials, ranging from bulk plastics to specialized coatings, pharmaceutical ...

TEMPERATURE PLATE DEVICE

A temperature plate device includes a plate body and a bent supporting structure. The plate body includes a first plate and a second plate. A chamber is defined by the first plate and the second plate. The first plate has a first step section. The second plate has a second step section corresponding to the first step section. The bent supporting structure is connected to and traverses the first step section between the first step section and the second step section. 1. A temperature plate device , comprising:a plate body comprising a first plate and a second plate, wherein a chamber is defined by the first plate and the second plate, the first plate has a first step section (A1), the second plate has a second step section corresponding to the first step section; anda bent supporting structure connected to and traversing the first step section between the first step section and the second step section.2. The temperature plate device of claim 1 , wherein a gap is between the bent supporting structure and the second step section.3. The temperature plate device of claim 1 , wherein the first plate comprises two flat sections at different levels claim 1 , and the first step section is connected with the two flat sections of the first plate claim 1 , wherein the second plate comprises two flat sections at different levels claim 1 , and the second step section is connected with the two flat sections of the second plate.4. The temperature plate device of claim 1 , wherein the first step section has a slope line portion between the two flat sections of the first plate claim 1 , and two ends of the first step section are bent and respectively connected with the two flat sections of the first plate claim 1 , wherein the second step section has a slope line portion between the two flat sections of the second plate claim 1 , and two ends of the second step section are bent and respectively connected with the two flat sections of the second plate.5. The temperature plate device ...

SYSTEMS AND METHODS FOR PROVIDING IMAGE PERSPECTIVE ADJUSTMENT AND AUTOMATIC FITTING

Systems, methods, and non-transitory computer-readable media can provide one or more options to adjust, in a virtual three-dimensional space, an image in an initial perspective. At least a first command, provided based on the one or more options, to adjust the image from the initial perspective into an adjusted perspective can be detected. The image can be adjusted, based on at least the first command, into the adjusted perspective in the virtual three-dimensional space to produce an adjusted image. A second command to modify a viewable area of the adjusted image can be detected. At least a portion of the adjusted image can be automatically fitted, when the second command has ceased, within a specified display area while one or more empty regions can be minimized in the specified display area. 1. A computer-implemented method comprising:adjusting, by a computing system, an image in a display area to produce an adjusted image, wherein the adjusting reveals one or more empty regions indicated by at least one edge of the adjusted image that is not parallel to at least one edge of the display area;determining, by the computing system, a minimum amount of zooming or moving to apply to the adjusted image to fill the display area and minimize the one or more empty regions and the at least one edge of the adjusted image; andbased on the determining, automatically fitting, by the computing system, at least a portion of the adjusted image to fill the display area while generating an animation of zooming or moving the adjusted image.2. The computer-implemented method of claim 1 , further comprising:providing, by the computing system, one or more options to adjust the image in a virtual three-dimensional space;detecting, by the computing system, a command to adjust the image; andwherein the adjusted image is produced based at least in part on the command.3. The computer-implemented method of claim 2 , wherein the one or more options to adjust the image comprises at least one of ...

METHODS AND SYSTEMS FOR GENERATION OF A TRANSLATABLE SENTENCE SYNTAX IN A SOCIAL NETWORKING SYSTEM

Sentence internationalization methods and systems are disclosed. The method may include: providing a developer interface to define an internationalized sentence syntax for an application on a social networking system, the internationalized sentence syntax for translating a natural language expression of a social graph edge of the social networking system; providing a sentence option on the developer interface to define grammar of the internationalized sentence syntax; generating a token structure including a language token to assist translation of the internationalized sentence syntax into a preferred language indicated by the language token, the token structure customizable via the developer interface to configure translation options; associating a social graph attribute with a first token of the token structure; and storing the sentence option and the token structure with the internationalized sentence syntax to facilitate run-time translation of the internationalized sentence syntax into the natural language expression in the preferred language. 1. A method comprising:providing a developer interface for the developer to define an internationalized sentence syntax for an application on a social networking system, the internationalized sentence syntax for translating a natural language expression of a social graph edge of the social networking system;providing a sentence option on the developer interface to define grammar of the internationalized sentence syntax;generating a token structure including a language token to assist translation of the internationalized sentence syntax into a preferred language indicated by the language token, the token structure customizable via the developer interface to configure translation options of the internationalized sentence syntax;associating a social graph attribute with a first token of the token structure; andstoring the sentence option and the token structure with the internationalized sentence syntax to facilitate run- ...

Kinase inhibitors for the treatment of disease

The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.

Heat sink assembly and clip thereof

A clip for fixing a heat sink on a retaining bracket includes an elastic supporter, an operating member, a movable fastener and a fixing bar. Two ends of the elastic supporter have a connecting portion and a first buckle portion, respectively. The operating member has a resisting portion, a pivot portion and an operating bar. The pivot portion pivots to the connecting portion. The movable fastener installs on the resisting portion and the connecting portion, and includes two sliding slots, a resisting surface and a second buckle portion. The resisting portion has an arc surface for resisting against the resisting surface. The distance between the apex of the arc surface and the pivot portion is the largest distance between the arc surface and the pivot portion. When the clip is locked, the junction of the resisting portion and the resisting surface excludes the apex of the arc surface.

SILICA COATING ON NANOPARTICLES

This invention relates to a method for synthesizing a SiO2-coated nanoparticle, the method comprising the step of reacting a hydroxyl-functionalised silane with a nanoparticle in a substantially aqueous phase under conditions to induce silanization of the nanoparticle. The method enables silanization of the nanoparticle in aqueous phase that is substantially free of organic solvents. 1. A method for synthesizing a SiO-coated nanoparticle , the method comprising steps of: [{'br': None, '[Math. 1]'}, {'br': None, 'sup': '1', 'sub': 2', 'n', '3, 'R—(CH)—Si(OH)\u2003\u2003Formula (I)'}], 'reacting a hydroxyl-functionalised silane having the following formula (I)'}{'sup': '1', 'wherein Ris selected from the group consisting of amino, glycidyl, mercapto and any mixture thereof; and'}n is an integer from 1 to 10;with a nanoparticle in a substantially aqueous phase and subsequently adding an aqueous ammonia solution under conditions to induce silanization of the nanoparticle.2. The method according to claim 1 , wherein the substantially aqueous phase comprises less than 5% (v/v) organic solvent or is substantially free of organic solvent.3. (canceled)4. The method according to claim 1 , wherein the substantially aqueous phase is substantially water.5. (canceled)6. The method according to claim 1 , wherein Ris mercapto.7. The method according to claim 1 , wherein n is 3.8. The method according to claim 1 , wherein the hydroxyl-functionalised silane is formed by the hydrolysis of a silane precursor.9. The method according to claim 8 , wherein the hydrolysis is performed by mixing the silane precursor with substantially water to form the hydroxyl-functionalised silane.10. The method according to claim 8 , wherein the silane precursor has the following formula (II):{'br': None, '[Math. 2]'}{'br': None, 'sup': 1', '2, 'sub': 2', 'n', '3, 'R—(CH)—Si(OR)\u2003\u2003Formula (II)'}{'sup': '1', 'wherein Ris selected from the group consisting of amino, glycidyl, mercapto and mixture ...

METHOD AND APPARATUS FOR CORRECTING STATE OF CHARGE

The present application provides a method and apparatus for correcting a state of charge. The method for correcting a state of charge comprises: determining an operating state of a battery cell, wherein the operating state comprises a discharging state or a charging state; and determining a corrected state of charge of the battery cell according to an acquired current open circuit voltage of the battery cell, an acquired current accumulative capacity of the battery cell, an accumulative capacity correspondence relationship corresponding to the operating state of the battery cell, and an open circuit voltage curve corresponding to a limit initial state of charge, wherein the accumulative capacity correspondence relationship comprises a correspondence relationship between a pre-measured open circuit voltage and an accumulative capacity threshold. A technical solution of the present application can be used to improve the accuracy of calculation of a state of charge. 1. A method for correcting a state of charge , comprising:determining an operating state of a battery cell, wherein the operating state comprises a charging state;acquiring a current open circuit voltage of the battery cell;acquiring a current accumulative charging capacity and a current accumulative discharging capacity of the battery cell; andusing, as a corrected state of charge of the battery cell, a state of charge corresponding to the current open circuit voltage in a charging open circuit voltage curve with an initial state of charge being 0% when the current accumulative discharging capacity is less than a maximum allowed accumulative discharging capacity corresponding to the current open circuit voltage, and the current accumulative charging capacity is greater than a minimum required accumulative charging capacity corresponding to the current open circuit voltage.2. The method for correcting a state of charge according to claim 1 , wherein the method for correcting a state of charge further ...

SYSTEM AND METHODS FOR USING LIMIT-USE ENCRYPTED CODE TO TRANSFER VALUES SECURELY AMONG USERS

A system and method for facilitating a secured value transfer. A first user and the system obtain a pair of encryption and decryption apparatuses. The first user creates a request including his unique identifier and a value to be transferred. The first user encrypts the request using the encryption apparatus and sends it to the second user. The second user sends to the system the request and the second user's unique identifier. The system uses the decryption apparatus to decrypt the request. The system checks the usage of the request against a threshold limit. After a successful usage check, the system then transfers the value from the first user to the second user. The system may comprise (a) a plurality of system server for exchanging data with users' personal computing devices, registering users, and conducting transactions, and (b) data storages storing user accounts and other persistent data. 1. A method of facilitating secured value transfer among users using limit-use code , comprising:creating, by a first device of a provider, an encryption apparatus and a decryption apparatus that is capable of decrypting data encrypted by the encryption apparatus;transmitting, by the first device of the provider, a first unique identifier of the provider and the decryption apparatus to a server;storing by the server, the decryption apparatus in association with the first unique identifier of the provider;creating, by the first device of the provider, a request containing at least a reference to value to be transferred to a recipient;encrypting, by the provider device, the request using the encryption apparatus;attaching, by the provider device, the first unique identifier of the provider to the encrypted request;transmitting the encrypted request and the attached first unique identifier of the provider to a second device of the recipient;transmitting, by the second device of the recipient to the server, the encrypted request and the attached first unique identifier of the ...

ELECTRONIC DEVICE WITH BANK STRUCTURES

Electronic device and associated methods with multiple well areas located on a common substrate, where each well area is defined by at least three bank structures that form the side walls of the well area. Within each well area, there are at least two electrode segments where the electrode segments are separated laterally by at least one insulating bank where the insulating bank(s) are thicker than the electrode segments. There is at least one charge transporting layer completely filling the well area in direct contact and overlying both the electrode segments and the insulating bank(s). The well areas are filled using solution methods such as inkjet. Such devices have improved uniformity across the active areas. 1. An electronic device with multiple well areas located on a common substrate , where:each well area is defined by at least three bank structures that form the side walls of the well area;at least two electrode segments located in the well area, the electrode segments being separated laterally by at least one insulating bank where the insulating bank(s) are thicker than the electrode segments; andat least one charge transporting layer completely filling the well area in direct contact and overlying both the electrode segments and the insulating bank(s).2. The electronic device according to where overlying the charge transporting layer are one or more active layer(s) and a counter electrode.3. The electronic device according to which is an OLED.4. The electronic device according to where the electrode segment is an anode and the charge transporting layer is a hole transporting layer.5. The electronic device according to where the electrode segment is an anode and the charge transporting layer is a hole-injection layer adjacent to the anode and a hole-transporting layer over the hole-injection layer.6. The electronic device according to where the electrode segment is a transparent metal oxide.7. The electronic device according to where the electrode segment ...

TREE STRUCTURE AWARE CACHE EVICTION POLICY

Nodes in tree data structure can be cached in a cache memory. When the cache memory becomes full, an eviction policy selects cached nodes based on their location in the tree data structure. The eviction policy selects cached nodes that correspond to leaf nodes in the tree data structure as candidates for eviction. The eviction policy selects cached nodes that correspond to internal (non-leaf) nodes from the lowest level possible for eviction, only if there are no cached leaf nodes. 1. A method comprising:receiving data to be stored in a tree data structure, the data to be stored in either a root node of the tree data structure, an internal node of the tree data structure, or a leaf node of the tree data structure;caching the received data in a cache memory; andevicting cached data cached in the cache memory, including selecting data to be evicted based on whether the cached data is stored in an internal node of the tree data structure or a leaf node of the tree data structure.2. The method of claim 1 , wherein claim 1 , when the cache memory includes cached data that is stored in one or more leaf nodes of the tree data structure claim 1 , then selecting cached data stored in one of the leaf nodes as the data to be evicted.3. The method of claim 1 , wherein claim 1 , when the cache memory includes cached data that is stored in one or more leaf nodes of the tree data structure claim 1 , then selecting least recently used data among the cached data stored in one of the leaf nodes as the data to be evicted.4. The method of claim 1 , wherein claim 1 , when the cache memory does not include any cached data that is stored in a leaf node in the tree data structure claim 1 , then selecting cached data that is stored in an internal node of the tree data structure as the data to be evicted.5. The method of claim 4 , wherein the internal node is at a lowest level in the tree data structure among internal nodes of the tree data structure.6. The method of claim 1 , wherein the ...

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase. 12. The compound of any of - , and , wherein Ris R.13. The compound of claim 12 , wherein Ris a Michael acceptor.15. The compound of any of - claim 12 , wherein Ris substituted or unsubstituted Calkyl.16. The compound of claim 15 , wherein Ris methyl.17. The compound of any of - claim 15 , wherein l is 1.18. The compound of claim 17 , wherein Ris meta to the point of attachment of the amide linker claim 17 , U.19. The compound of any of - claim 17 , wherein l is 2.20. The compound of claim 19 , wherein two Rgroups are meta to the point of attachment of the amide linker claim 19 , U.21. The compound of claim 19 , wherein one Rgroup is meta to the point of attachment of the amide linker claim 19 , U; and the second Rgroup is para to the point of attachment of the amide linker claim 19 , U.22. The compound of any of - claim 19 , wherein one Rgroup is substituted or unsubstituted Calkyl.23. The compound of claim 22 , wherein claim 22 , one Rgroup is Calkyl substituted with one —CN group.25. The compound of any of - claim 22 , wherein one Rgroup is substituted or unsubstituted —CH-(piperazinyl).27. The compound of any of - claim 22 , wherein claim 22 , one Rgroup is haloalkyl.28. The compound of claim 27 , wherein one Rgroup is ...

STORAGE APPARATUS, MOBILE TERMINAL AND IMAGE PROCESSING METHOD THEREOF

Disclosed are a storage apparatus, a mobile terminal and an image processing method thereof. The image processing method comprises the following steps: acquiring a feature index parameter of each image; acquiring an operation instruction, and classifying images according to the operation instruction; determining, according to the classification of the images, whether a user is satisfied with an image; and if it is determined that the user is satisfied with the image, correcting a photographing parameter of a camera of a mobile terminal according to a feature index parameter of the satisfactory image, such that an image photographed thereby better conforms to the requirements of the user. Therefore, the present invention can directly obtain an image that a user is satisfied with, thereby saving on the screening time for a user, and thus improving the user experience. 1. A storage device storing program instructions executable by a processor to perform operations of:obtaining a characteristic indication parameter of each of images;obtaining an operation instruction and classifying the images according to the operation instruction;determining whether a user satisfies with the images according to classifications of the images;if determining that the user satisfies with the images, then adjusting an imaging parameter of a camera of the mobile terminal according to the characteristic indication parameters of the images such that the camera is capable of generating images that meet the user's demands.2. The storage device of claim 1 , wherein the characteristic indication parameter comprises a peak signal-to-noise ratio (PSNR) claim 1 , a dynamic range claim 1 , a resolution claim 1 , a color accuracy claim 1 , and an auto white balance error (AWB error).3. The storage device of claim 1 , wherein the program instructions is executable by the processor to further perform operations of:classifying the image into uploaded images, deleted images, satisfying images or ...

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase. 57-. (canceled)1012-. (canceled)15. (canceled)17. The compound of claim 1 , wherein Ris substituted or unsubstituted Calkyl.18. (canceled)19. The compound of claim 1 , wherein l is 1.2023-. (canceled)24. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted Calkyl.2526-. (canceled)27. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted —CH-(piperazinyl).28. (canceled)29. The compound of claim 1 , wherein claim 1 , one Rgroup is haloalkyl.30. (canceled)31. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted imidazoyl.32. (canceled)33. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted piperazinyl.34. (canceled)35. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted morpholine.3639-. (canceled)4245-. (canceled)4756-. (canceled)58. (canceled) The present application claims priority under 35 U.S.C. § 119(e) to U.S. provisional patent applications, U.S. Ser. No. 62/036,934, filed Aug. 13, 2014 and U.S. Ser. No. 61/915,684, filed Dec. 13, 2013, the entire contents of which are incorporated herein by reference.This invention was made with U.S. Government support under grants 5R01CA130876-05, 5P50CA090578- ...

ORGANIC ELECTRONIC DEVICES WITH FLUOROPOLYMER BANK STRUCTURES

An electronic device and methods for its preparation comprising an active area between first and second conductive layers on a substrate; the active area is in a well whose bottom is a patterned first conductive layer on the substrate, the sides of the well are bank structures comprising a non-radiative active fluoropolymer which overlap the edges of the first conductive layer and which are in contact with the substrate. The well contains active materials, preferably introduced by a solution method such as ink-jet. The second conductive layer is located over the top of the well. 127.-. (canceled)28. An electronic device comprising a well area defined by:a common substrate with an overlying conductive first layer that is patterned into separate sections, each section having an upper surface, at least 3 edges and a distance between each of the edges;at least three bank structures, each separated by a minimum distance, each in direct contact with both the substrate and at least one first conductive layer sections, each bank structure having a maximum thickness greater than the thickness of the first conductive layer sections, and together form the sides of the well;all of the edges of at least one first conductive layer section are partially overlapped by a bank structure such that the distances between the edges of the first conductive layer section are all greater than the minimum distances between all of the bank structures so that the exposed upper surface of the conductive layer section forms the bottom of the well;at least one active layer is located in the well on the exposed first conductive layer section and between the bank structures;a second conductive layer is located on the active layer(s); andthe bank structures comprise a non-radiative active fluoropolymer.29. The electronic device according to claim 28 , wherein the device is an organic thin-film transistor (OTFT) where at least one active layer is an organic semiconducting or charge-carrying material. ...

THREAT DETECTION PLATFORMS FOR DETECTING, CHARACTERIZING, AND REMEDIATING EMAIL-BASED THREATS IN REAL TIME

Conventional email filtering services are not suitable for recognizing sophisticated malicious emails, and therefore may allow sophisticated malicious emails to reach inboxes by mistake. Introduced here are threat detection platforms designed to take an integrative approach to detecting security threats. For example, after receiving input indicative of an approval from an individual to access past email received by employees of an enterprise, a threat detection platform can download past emails to build a machine learning (ML) model that understands the norms of communication with internal contacts (e.g., other employees) and/or external contacts (e.g., vendors). By applying the ML model to incoming email, the threat detection platform can identify security threats in real time in a targeted manner. 1. A computer-implemented method comprising:establishing, via an application programming interface, a connection with a storage medium that includes a series of past communications received by an employee of an enterprise;downloading, via the application programming interface, a first portion of the series of past communications corresponding to a first interval of time into a local processing environment;building a machine learning (ML) model for the employee by providing the first portion of the series of past communications to the ML model as training data;receiving, via the application programming interface, a communication addressed to the employee; andestablishing whether the communication represents a security risk by applying the ML model to the communication.2. The computer-implemented method of claim 1 , further comprising:receiving input indicative of an approval from an administrator associated with the enterprise to access the series of past communications;wherein said establishing is performed in response to receiving the input.3. The computer-implemented method of claim 1 , wherein the series of past communications includes multiple emails that were ...

HEAT DISSIPATION ASSEMBLY

A heat dissipation assembly includes a condenser, an evaporator, a vapor conduit, and a liquid conduit. The condenser has a condensing chamber therein. Two ends of the vapor conduit are respectively connected to the condenser and the evaporator. Two ends of the liquid conduit are respectively connected to the condenser and the evaporator. A geometric center of the liquid conduit in the condensing chamber is lower than or equal to a geometric center of the condensing chamber. 1. A heat dissipation assembly , comprising:a condenser having a condensing chamber, a first oblique surface and a second oblique surface therein, wherein the first oblique surface is between a sidewall of the condensing chamber and the second oblique surface, and a length of the first oblique surface is shorter than a length of the second oblique surface;an evaporator;a vapor conduit, wherein a first end of the vapor conduit is connected to the condenser, and a second end of the vapor conduit is connected to the evaporator; anda liquid conduit, wherein a first end of the liquid conduit is connected to the condenser, and a second end of the liquid conduit is connected to the evaporator,wherein a geometric center of the liquid conduit in the condensing chamber is lower than or equal to a geometric center of the condensing chamber, the second oblique surface is located between the first end of the vapor conduit in the condensing chamber and the first end of the liquid conduit in the condensing chamber, and the first end of the liquid conduit in the condensing chamber is on the second oblique surface.2. The heat dissipation assembly of claim 1 , wherein the evaporator has an evaporating chamber claim 1 , and a geometric center of the liquid conduit in the evaporating chamber is lower than or equal to a geometric center of the evaporating chamber.3. The heat dissipation assembly of claim 2 , wherein the evaporating chamber has a first portion and a second portion that communicates with the first ...

Isopeptide Bond Formation in Bacillus Species and Uses Thereof

A mechanism for a unique isopeptide bond formation between polypeptides is disclosed as well as sequence motifs used in such bond formation and methods of using such sequence motifs. 1Bacillus. A fusion protein , said fusion protein containing at least one donor sequence derived from a species and a second polypeptide.2. The fusion protein of claim 1 , wherein the donor sequence is polypeptide sequence from a BclA claim 1 , CotY claim 1 , ExsY or ExsB polypeptide.3. The fusion protein of claim 1 , wherein the donor sequence is polypeptide sequence from a BclA polypeptide.4. The fusion protein of claim 1 , wherein the donor sequence is a full length BclA claim 1 , CotY claim 1 , ExsY or ExsB polypeptide.5. The fusion protein of claim 1 , wherein the donor sequence is a fragment of a full length BclA claim 1 , CotY claim 1 , ExsY or ExsB polypeptide.6. The fusion protein of claim 1 , wherein the donor sequence is a fragment of a full length BclA claim 1 , CotY claim 1 , ExsY or ExsB polypeptide claim 1 , the fragment selected from the group consisting of: the first 40 amino acid residues claim 1 , the first 38 amino acid residues claim 1 , the first 20 amino acid residues claim 1 , the first 10 amino acid residues claim 1 , amino acid residues 2-40 claim 1 , amino acid residues 2-38 and amino acid residues 20-38 claim 1 , of the foregoing polypeptides.7. The fusion protein of claim 1 , wherein the second polypeptide of the fusion protein is taken from a polypeptide that is different from the polypeptide from which the donor sequence is derived.8Bacillus. A fusion protein claim 1 , said fusion protein containing at least one acceptor sequence derived from a species and a second polypeptide.9. The fusion protein of claim 8 , wherein the acceptor sequence is polypeptide sequence from a BxpB claim 8 , CotE claim 8 , CotY or ExsY polypeptide.10. The fusion protein of claim 8 , wherein the acceptor sequence is polypeptide sequence from a BxpB polypeptide.11. The fusion ...

FORMULATION OF AN ORGANIC FUNCTIONAL MATERIAL COMPRISING AN EPOXY GROUP CONTAINING SOLVENT

The present invention relates to formulations containing at least one organic functional material and at least a first organic solvent, wherein said first organic solvent contains at least one epoxy-group as well as to electronic devices prepared by using these formulations. 123.-. (canceled)24. A formulation containing at least one organic functional material and at least a first organic solvent , wherein said first organic solvent contains at least one epoxy-group.30. The formulation according to claim 24 , wherein the first solvent has a surface tension of ≥25 mN/m.31. The formulation according to claim 24 , wherein the content of the first solvent is in the range from 50 to 100 vol.-% claim 24 , based on the total amount of solvents in the formulation.32. The formulation according to claim 24 , wherein the first solvent has a boiling point in the range from 100 to 400° C.33. The formulation according to claim 24 , wherein the formulation comprises at least one second solvent which is different from the first solvent.34. The formulation according to claim 33 , wherein the second solvent has a boiling point in the range from 100 to 400° C.35. The formulation according to claim 24 , wherein the at least one organic functional material has a solubility in the first as well as in the second solvent in the range from 1 to 250 g/l.36. The formulation according to claim 24 , wherein the formulation has a surface tension in the range from 1 to 70 mN/m.37. The formulation according to claim 24 , wherein the formulation has a viscosity in the range from 1 to 50 mPa s.38. The formulation according to claim 24 , wherein the content of the at least one organic functional material in the formulation is in the range from 0.001 to 20 weight-% claim 24 , based on the total weight of the formulation.39. The formulation according to claim 24 , wherein the at least one organic functional material is selected from the group consisting of organic conductors claim 24 , organic ...

ORGANIC SEMICONDUCTOR FORMULATIONS

Embodiments in accordance with the present invention relate generally to formulations for use in organic semiconductor layers of organic electronic devices, and more specifically in organic field effect transistors, to organic semiconductor layers prepared from such formulations, and to organic electronic devices and organic field effect transistors encompassing such organic semiconductor layers. 1. A formulation comprising an organic semiconductor (OSC) and a polycycloolefinic polymer comprising one or more pendant reactive groups.2. The formulation according to claim 1 , wherein the reactive group comprises a hydroxyl portion or an olefinic portion.323-. (canceled)30. The formulation according to claim 1 , wherein the OSC comprises a small molecule.31. The formulation according to claim 30 , wherein the OSC comprises an oligoacene that is optionally substituted with two or more alkylsilylethynyl groups.32. The formulation according to claim 1 , further comprising one or more organic solvents.33. The formulation according to claim 32 , wherein the organic solvent is selected from cyclohexylene claim 32 , mesitylene claim 32 , xylene claim 32 , diethylbenzene claim 32 , indane and tetralin.34. An OSC layer obtained through the use of a formulation according to .35. A process of preparing an OSC layer claim 1 , comprising depositing a formulation according to onto a substrate and claim 1 , in case the formulation comprises a solvent claim 1 , removing the solvent.36. An organic electronic (OE) device comprising an OSC layer being obtained through the use of a formulation according to claim 1 , said OE device further comprising a dielectric or passivation layer obtained by vapor deposition of a p-xylylene onto said OSC layer.37. A process of prepring an OE device according to claim 36 , comprising providing a dielectric or passivation layer obtained by vapor deposition of a p-xylylene onto said OSC layer.38. A process of preparing an OE device according to claim 36 , ...

QUININE AND ITS USE TO GENERATE INNATE IMMUNE RESPONSE

The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production. 1. A method of treating a viral infection in a subject having an upper respiratory infection , comprising:dispersing as particulate a formulation of a bitter taste receptor agonist;applying the dispersed formulation onto the mucosal surface of an upper respiratory cavity of the subject; andgenerating NO production or stimulating antimicrobial peptide production, or both, through the stimulation of bitter taste receptors.2. The method of claim 1 , wherein the bitter taste receptor agonist is an agonist that causes bitter taste receptor signaling resulting in NO production or stimulating antimicrobial peptide production claim 1 , or a combination thereof.3. The method of claim 2 , wherein the bitter taste receptor agonist is selected from the group consisting of: denatonium claim 2 , phenylthiocarbamide (PTC) claim 2 , a homoserine lactone claim 2 , sodium thiocyanate (NaSCN) claim 2 , 6-n-propylthio uracil (PROP or PTU) claim 2 , parthenolide claim 2 , amarogentin claim 2 , antidesma (including its extracts) claim 2 , colchicine claim 2 , dapsone claim 2 , salicin claim 2 , chrysin claim 2 , apigenin claim 2 , quinine claim 2 , and quinine salts.4. The method of claim 1 , wherein the viral infection is an infection resulting from a virus selected from the group consisting of: SARS; SARS-CoV-2; MERS-CoV; SARS-CoV; influenza A claim 1 , influenza B; parainfluenza virus; rhinovirus; adenovirus; human metapneumovirus; respiratory syncytial virus; and non-pathogenic coronaviruses.5. The method of claim 1 , wherein the dispersing and applying steps are repeated three times per ...

METHODS AND SYSTEMS FOR GENERATION OF A TRANSLATABLE SENTENCE SYNTAX IN A SOCIAL NETWORKING SYSTEM

Sentence internationalization methods and systems are disclosed. The method may include: providing a developer interface to define an internationalized sentence syntax for an application on a social networking system, the internationalized sentence syntax for translating a natural language expression of a social graph edge of the social networking system; providing a sentence option on the developer interface to define grammar of the internationalized sentence syntax; generating a token structure including a language token to assist translation of the internationalized sentence syntax into a preferred language indicated by the language token, the token structure customizable via the developer interface to configure translation options; associating a social graph attribute with a first token of the token structure; and storing the sentence option and the token structure with the internationalized sentence syntax to facilitate run-time translation of the internationalized sentence syntax into the natural language expression in the preferred language. 1. A method comprising:providing a developer interface for the developer to define an internationalized sentence syntax for an application on a social networking system, the internationalized sentence syntax for translating a natural language expression of a social graph edge of the social networking system;providing a sentence option on the developer interface to define grammar of the internationalized sentence syntax;generating a token structure including a language token to assist translation of the internationalized sentence syntax into a preferred language indicated by the language token, the token structure customizable via the developer interface to configure translation options of the internationalized sentence syntax;associating a social graph attribute with a first token of the token structure; andstoring the sentence option and the token structure with the internationalized sentence syntax to facilitate run- ...

SELF-ALIGNED CONTACTS FOR THIN FILM TRANSISTORS

Embodiments herein describe techniques for a semiconductor device, which may include a substrate, and a U-shaped channel above the substrate. The U-shaped channel may include a channel bottom, a first channel wall and a second channel wall parallel to each other, a source area, and a drain area. A gate dielectric layer may be above the substrate and in contact with the channel bottom. A gate electrode may be above the substrate and in contact with the gate dielectric layer. A source electrode may be coupled to the source area, and a drain electrode may be coupled to the drain area. Other embodiments may be described and/or claimed. 1. A semiconductor device , comprising:a substrate;a U-shaped channel above the substrate, wherein the U-shaped channel includes a channel bottom, a first channel wall and a second channel wall parallel to each other, a source area, and a drain area, the first channel wall intersects with the channel bottom at a first end and intersects with the source area at a second end, and the second channel wall intersects with the channel bottom at a first end and intersects with the drain area at a second end;a gate dielectric layer above the substrate and in contact with the channel bottom;a gate electrode above the substrate and in contact with the gate dielectric layer; anda source electrode coupled to the source area, and a drain electrode coupled to the drain area.2. The semiconductor device of claim 1 , further comprising:a first spacer next to the first channel wall, the source area, and the source electrode; anda second spacer next to the second channel wall, the drain area, and the drain electrode.3. The semiconductor device of claim 1 , wherein the gate electrode is a bottom gate electrode between the substrate and the channel bottom claim 1 , the gate dielectric layer is between the gate electrode and the channel bottom claim 1 , and the semiconductor device further includes a passivation layer between the first channel wall and the ...

THIN-FILM TRANSISTORS WITH LOW CONTACT RESISTANCE

Techniques are disclosed for forming thin-film transistors (TFTs) with low contact resistance. As disclosed in the present application, the low contact resistance can be achieved by intentionally thinning one or both of the source/drain (S/D) regions of the thin-film layer of the TFT device. As the TFT layer may have an initial thickness in the range of 20-65 nm, the techniques for thinning the S/D regions of the TFT layer described herein may reduce the thickness in one or both of those S/D regions to a resulting thickness of 3-10 nm, for example. Intentionally thinning one or both of the S/D regions of the TFT layer induces more electrostatic charges inside the thinned S/D region, thereby increasing the effective dopant in that S/D region. The increase in effective dopant in the thinned S/D region helps lower the related contact resistance, thereby leading to enhanced overall device performance. 1. An integrated circuit (IC) structure comprising:a top semiconductor fin extending in a length direction;a bottom semiconductor fin extending in the length direction, the bottom semiconductor fin being under and vertically aligned with the top semiconductor fin;a top gate structure in contact with a portion of the top semiconductor fin;a top source region and a top drain region each adjacent to the portion of the top semiconductor fin, such that the portion of the top semiconductor fin is between the top source region and the top drain region;a bottom gate structure in contact with a portion of the bottom semiconductor fin; anda bottom source region and a bottom drain region each adjacent to the portion of the bottom semiconductor fin, such that the portion of the bottom semiconductor fin is between the bottom source region and the bottom drain region,wherein heights, widths, or both the heights and widths of the portions of the top and bottom semiconductor fins are different.2. The IC structure of claim 1 , wherein one or both of the height and width of the top ...

DISABLING STYLUS TO PREVENT WORN TIP PERFORMANCE DEGRADATION AND SCREEN DAMAGE

A level of wear of a stylus tip can be estimated and in accordance with a determination that the level of wear of the stylus tip exceeds a threshold, the stylus input functionality of an electronic device can be disabled. The threshold can be set such that the stylus can be disabled before the stylus sensing performance degrades to a degree perceptible to a human and/or before exposing internal portions of the stylus that can scratch a touch screen. Additionally or alternatively, a notification can be provided to indicate to a user that the stylus tip should be replaced. In some examples, the estimated level of wear can also be used to provide warning notifications. Stylus tip wear can be estimated, for example, based on a detected total signal strength or based on an estimated total distance traversed by the stylus tip across a surface. 1. A system comprising:a touch sensor panel; and tracking a parameter representative of an amount of tip wear of a tip portion of an active stylus, the parameter updated based on an input received at the touch sensor panel from the active stylus;', 'in accordance with a determination that the parameter does not exceed a first threshold, performing an action associated with the input from the active stylus; and', 'in accordance with a determination that the parameter exceeds the first threshold, rejecting the input from the active stylus., 'a processor coupled to the touch sensor panel and capable of2. The system of claim 1 , the processor further capable of:in accordance with the determination that the parameter exceeds the first threshold, displaying a notification to replace the tip portion of the active stylus.3. The system of claim 1 , the processor further capable of:in accordance with a determination that the parameter does not exceed the first threshold and that the parameter exceeds a second threshold, displaying a warning notification.4. The system of claim 1 , wherein the parameter is a measure of a total signal strength ...

PRINT MEDIA AMOUNT DETERMINATION

The present subject matter describes determination of amount of print media present in an input tray of a printing system. In an example implementation of the present subject matter, a current operating torque of a motor that moves a pick arm for drawing print media from the input tray is monitored. The current operating torque is monitored while the pick arm is moved between a rest position and a pick-ready position. Based on the monitored operating torque, it is determined whether amount of print media present in the input tray is one of below and above a predefined amount of print media. 1. A method comprising:monitoring a current operating torque of a motor that moves a pick arm for drawing print media from an input tray of a printing system, wherein the current operating torque is monitored while the pick arm is moved between a rest position and a pick-ready position; anddetermining, based on the monitored operating torque, whether amount of print media present in the input tray is one of below and above a predefined amount of print media.2. The method as claimed in claim 1 , wherein the current operating torque is monitored after a specific number of rotations of the motor from a time instance when the motor starts to move the pick arm from the rest position claim 1 , wherein the monitoring comprises:determining whether the motor has completed the specific number of rotations; andupon determining that the motor has completed the specific number of rotations, comparing the current operating torque of the motor with a torque threshold, wherein the torque threshold is a predetermined torque value of the motor to lift the pick arm from the pick-ready position, wherein at the pick-ready position the pick arm rests on the predefined amount of print media.3. The method as claimed in claim 2 , wherein determining whether amount of print media present in the input tray is one of below and above the predefined amount of print media comprises:when magnitude of the ...

MEDIA DETECTORS

A printing apparatus determines a change in torque of a motor that moves a pick arm for translating print media, determines based on the change in torque whether a media in present adjacent to the pick arm. 1. An apparatus comprising:a processor; anda memory on which is stored machine readable instructions that are executable by the processor to:determine a change in torque of a motor, the motor to power a pick arm for translating media;determine whether the change in torque is within a torque threshold; andin response to the change in torque being within the torque threshold, determine that a media is present adjacent to a pick arm.2. The apparatus of claim 1 , wherein the instructions are further to cause the processor to:determine whether a level of media in a media bin is less than a low media threshold;in response to a determination that the media in the media bin is less than the low media threshold, lower the pick arm from a rest position to a pick ready position; andtranslate the media on the media bin until the media buckles against a buckling surface opposite the pick arm.3. The apparatus of claim 1 , wherein the instructions are further to cause the processor to:determine whether a level of the media in a media bin is less than a low media threshold; andin response to a determination that the media in the media bin is less than the low media threshold, control the pick roller to buckle the media in the media bin between the pick arm and a buckling surface opposite a pick arm.4. The apparatus of claim 1 , wherein the instructions are further to cause the processor to:determine, based on the determined change in torque, a stiffness value of media on a media bin; anddetermine, based on the stiffness value of the media, a type of media on the media bin.5. The apparatus of claim 1 , wherein the instructions are further to cause the processor to:determine, based on the determined change in torque, whether an accessory is present.6. The apparatus of claim 1 , ...

PROJECTION DEVICE AND FABRICATION METHOD OF A POLARIZATION GRATING

A projection device including a light source, a reflective spatial polarization modulator, a polarization grating, and a projection lens is provided. The light source is configured to provide a light beam. The reflective spatial polarization modulator is disposed on a path of the light beam and configured to reflect the light beam and modulate a polarization state of the light beam. The polarization grating is disposed on the path of the light beam between the light source and the reflective spatial polarization modulator, wherein the reflective spatial polarization modulator reflects the light beam from the reflective spatial polarization modulator back to the polarization grating. The projection lens is disposed on the path of the light beam from the reflective spatial polarization modulator, wherein the polarization grating is disposed on the path of the light beam between the reflective spatial polarization modulator and the projection lens. 1. A projection device comprising:a light source configured to provide a light beam;a reflective spatial polarization modulator disposed on a path of the light beam and configured to reflect the light beam and modulate a polarization state of the light beam;a polarization grating disposed on the path of the light beam between the light source and the reflective spatial polarization modulator, wherein the reflective spatial polarization modulator reflects the light beam from the reflective spatial polarization modulator back to the polarization grating; anda projection lens disposed on the path of the light beam from the reflective spatial polarization modulator, wherein the polarization grating is disposed on the path of the light beam between the reflective spatial polarization modulator and the projection lens.2. The projection device according to claim 1 , wherein the reflective spatial polarization modulator is a liquid-crystal-on-silicon (LCOS) panel.3. The projection device according to claim 2 , wherein the LCOS panel ...

METHOD FOR PRODUCING ORGANIC ELECTRONIC DEVICES WITH BANK STRUCTURES, BANK STRUCTURES AND ELECTRONIC DEVICES PRODUCED THEREWITH

The present invention relates to a process for producing an organic electronic device, wherein a layer is selectively swelled with a swelling solvent so as to form bank structures allowing the deposition of the semiconductor material in a specific and well-defined area. The present invention further relates to bank structures, organic electronic devices and products or assemblies produced by said process. 1. A process for preparing an electronic device , wherein a layer is selectively swelled with a swelling solvent , thereby forming bank structures , which define a well.2. A process according to claim 1 , said process comprising the following steps:a) depositing a material comprising a polycycloolefinic polymer on a substrate to form a layer; andb) selectively swelling said layer with a swelling solvent, thereby forming bank structures, which define a well.3. A process according to claim 1 , said process comprising the following steps:a′) depositing a material comprising a polycycloolefinic polymer on a substrate to form a layer;b′) exposing a part of the surface of said layer to actinic radiation; andc′) selectively swelling said layer with a swelling solvent, thereby forming bank structures, which define a well.4. A process according to claim 1 , said process comprising the following steps:{'b': '1', 'I-a) providing a substrate ();'}{'b': 2', '1, 'I-b) forming a gate electrode () on said substrate ();'}{'b': 2', '1', '3, 'I-c) depositing a dielectric material comprising a polycycloolefinic polymer on said gate electrode () and said substrate () to form a dielectric layer ();'}{'b': 5', '3', '5', '6', '5, 'I-d) forming source and drain electrodes () on said dielectric layer (), such that said source and drain electrodes () are spaced apart with a channel region () located between said source and drain electrodes ();'}{'b': 3', '6, 'I-e) exposing a part of the surface of said dielectric layer () to actinic radiation such that the exposed part extends at least over ...

FABRICATION METHOD OF A POLARIZATION GRATING

A fabrication method of a polarization grating is provided. The method includes providing a polarization-sensitive material; and causing two orthogonally polarized lights to scan the polarization-sensitive material and to meet on the polarization-sensitive material. 1. A fabrication method of a polarization grating comprising:providing a polarization-sensitive material; andcausing two orthogonally polarized lights to scan the polarization-sensitive material and to meet on the polarization-sensitive material, so as to form the polarization grating.2. The fabrication method of the polarization grating according to claim 1 , wherein an included angle is formed between the two orthogonally polarized lights and at an incident position of the two orthogonally polarized lights incident on the polarization-sensitive material.3. The fabrication method of the polarization grating according to further comprising:emitting an original light; andsplitting the original light into the two orthogonally polarized lights.4. The fabrication method of the polarization grating according to claim 3 , wherein the original light is a laser light.5. The fabrication method of the polarization grating according to claim 3 , wherein the method of splitting the original light into the two orthogonally polarized lights comprises disposing a polarizing beam splitter on a path of the original light to split the original light into the two orthogonally polarized lights.6. The fabrication method of the polarization grating according to claim 1 , wherein the polarization-sensitive material is a liquid crystal material. This application is a divisional application of and claims the priority benefit of U.S. application Ser. No. 14/205,382, filed on Mar. 12, 2014, now allowed. The entirety of the above-mentioned patent application is hereby incorporated by reference herein and made a part of this specification.1. Field of the InventionThe invention generally relates to a display device and a fabrication ...

METHOD OF MANUFACTURING HEAT SINK MODULE

In a heat sink module and a manufacturing method thereof, the method includes steps of: forming a heat dissipation fin set by aluminum extrusion process, wherein the heat dissipation fin set includes a plate, a plurality of fins extending from one side of the plate and being arranged spaced apart from one another, and a joint portion formed on the other side of the plate; placing the plate in a mold; injecting molten metal into the mold; forming a base by die-casting of the molten metal. The plate and the joint portion are wrapped by the base. The joint portion forms a connection structure including a bump and a notch fitted with the bump, so as to connect and fix the base and the heat dissipation fin set. The heat sink module has the strengthened connection structure and the fins with a superior aspect ratio. 1. A method of manufacturing heat sink module , comprising steps of:forming a heat dissipation fin set by an aluminum extrusion process, wherein the heat dissipation fin set comprises a plate, a plurality of fins extending from one side of the plate and being arranged spaced from one another, and a joint portion formed on the other side of the plate;placing the plate in a mold;injecting molten metal into the mold; andforming a base by die-casting of the molten metal, wherein the plate and the joint portion are wrapped by the base;wherein the joint portion forms a connection structure, and the connection structure comprises at least one bump and at least one notch fitted with the bump, so as to connect and fix the base and the heat dissipation fin set.2. The method of claim 1 , wherein the bump is a trapezoidal block gradually widening as it protrudes from a surface of the plate toward the base claim 1 , and the groove is a trapezoidal notch denting from a surface of the base.3. The method of claim 2 , wherein the bump includes a connection depth claim 2 , the connection depth is smaller than a plate thickness of the plate.4. The method of claim 2 , wherein an ...

METHOD OF DESIGNING A CIRCUIT AND SYSTEM FOR IMPLEMENTING THE METHOD

A method of designing a circuit includes receiving a circuit design, and determining a temperature change of at least on back end of line (BEOL) element of the circuit design. The method further includes identifying at least one isothermal region within the circuit design; and determining, using a processor, a temperature increase of at least one front end of line (FEOL) device within the at least one isothermal region. The method further includes combining the temperature change of the at least one BEOL element with the temperature change of the at least one FEOL device, and comparing the combined temperature change with a threshold value. 1. A method of designing a circuit , the method comprising:determining a temperature change of at least one back end of line (BEOL) element of a circuit design;identifying at least one isothermal region within the circuit design;determining, using a processor, a temperature increase of at least one front end of line (FEOL) device within the at least one isothermal region;combining the temperature change of the at least one BEOL element with the temperature change of the at least one FEOL device; andcomparing the combined temperature change with a threshold value.2. The method of claim 1 , wherein determining the temperature change of the at least one FEOL device comprises determining a temperature change of each FEOL device of a plurality of FEOL devices.3. The method of claim 2 , wherein combining the temperature change of the at least one BEOL element with the temperature change of the at least one FEOL device comprises:comparing the temperature change of each FEOL device of the plurality of FEOL devices;determining a maximum temperature change based on the comparison; andcombining the temperature change of the at least one BEOL element with the maximum temperature change.4. The method of claim 2 , wherein combining the temperature change of the at least one BEOL element with the temperature change of the at least one FEOL ...

Transgenic plants and methods of using same

Provided herein are plants having altered expression of a coding region encoding a hydroxyproline-rich glycoprotein. In some embodiments the expression is decreased, and the resulting plant has decreased recalcitrance, increased growth, or a combination thereof. In some embodiments the expression is increased, and the resulting plant has decreased growth, biomass that is more cross-linked, biomass that is more dense, or a combination thereof. Also provided are methods for making and using such plants.

METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT

A method, an apparatus and a computer program product are disclosed. The method includes determining a current working state and configuration of a device, detecting information, controlling the device to a second working state, and configuring the device. The apparatus includes a housing and a processor that determines a current working state and configuration, detects information, controls the apparatus to a second working state, and configures the apparatus. The computer program product includes code to perform determination of a current working state and configuration, detection of information, control of the device to adjust to a second working state, and configuration of the device. 1. A method , comprisingdetermining a current working state of a deformable electronic device to be a first working state;determining a current configuration of the deformable electronic device to be a first configuration corresponding to the first working state;detecting information;controlling the deformable electronic device to be adjusted from the first working state to a second working state as a result of determining that the information satisfies a preset condition; andconfiguring the deformable electronic device.2. The method of claim 1 , wherein configuring the deformable electronic device comprisesconfiguring the deformable electronic device from the first configuration to a second configuration corresponding to the second working state as a result of determining that the information satisfies the preset condition.3. The method of claim 1 , wherein configuring the deformable electronic device comprisesconfiguring the deformable electronic device from the first configuration to a second configuration corresponding to the second working state in response to receiving an external force applied to the deformable electronic device.4. The method of claim 1 , whereinthe information comprises physiological parameters of a user,the information satisfies the preset condition if the ...

System and Method for Providing Category-Based User Management Notifications

The present application provides systems and methods for providing category-based user management notifications. The server provides at least one processor; and at least one memory including computer program code. The at least one memory and the computer program code are configured to, with the at least one processor, cause the server at least to: retrieve historical transaction data, the historical transaction data relating to a plurality of historical transactions that have been conducted using a plurality of accounts linked to an account identifier; classify the plurality of historical transactions into a plurality of categories of transactions based on a respective merchant identifier associated with each of the plurality of historical transactions; and provide a category-based user communication in regard to the historical transactions pertaining to one or more of the plurality of categories of transactions. 1. A server for providing category-based user management notifications , the server comprising:at least one processor; and retrieve historical transaction data, the historical transaction data relating to a plurality of historical transactions that have been conducted using a plurality of accounts linked to an account identifier;', 'classify the plurality of historical transactions into a plurality of categories of transactions based on a respective merchant identifier associated with each of the plurality of historical transactions; and', 'provide a category-based user communication in regard to the historical transactions pertaining to one or more of the plurality of categories of transactions., 'at least one memory in communication with the at least one processor, the at least one memory including computer program code, which when executed by the at least one processor, causes the server to2. The server according to claim 1 , wherein the computer program code claim 1 , when executed by the at least one processor claim 1 , further causes the server to ...

AIR GAP FOR THIN FILM TRANSISTORS

Embodiments herein describe techniques for a thin-film transistor (TFT), which may include a gate electrode above a substrate and a channel layer above the gate electrode. A source electrode may be above the channel layer and adjacent to a source area of the channel layer, and a drain electrode may be above the channel layer and adjacent to a drain area of the channel layer. A passivation layer may be above the channel layer and between the source electrode and the drain electrode, and a top dielectric layer may be above the gate electrode, the channel layer, the source electrode, the drain electrode, and the passivation layer. In addition, an air gap may be above the passivation layer and below the top dielectric layer, and between the source electrode and the drain electrode. Other embodiments may be described and/or claimed. 1. A thin film transistor (TFT) , comprising:a gate electrode above a substrate;a channel layer above the gate electrode;a source electrode above the channel layer and adjacent to a source area of the channel layer;a drain electrode above the channel layer and adjacent to a drain area of the channel layer;a passivation layer above the channel layer and between the source electrode and the drain electrode;a top dielectric layer above the gate electrode, the channel layer, the source electrode, the drain electrode, and the passivation layer; andan air gap above the passivation layer and below the top dielectric layer, and between the source electrode and the drain electrode.2. The TFT of claim 1 , wherein the air gap has a thickness between the passivation layer and the top dielectric layer in a range of about 0.5 nanometers (nm) to about 20 nm.3. The TFT of claim 1 , wherein the channel layer includes indium doped zinc oxide (IZO) claim 1 , zinc tin oxide (ZTO) claim 1 , amorphous silicon (a-Si) claim 1 , amorphous germanium (a-Ge) claim 1 , low-temperature polycrystalline silicon (LTPS) claim 1 , transition metal dichalcogenide (TMD) claim 1 ...

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase. 67-. (canceled)1011-. (canceled)12. The compound of claim 1 , wherein Ris R.13. (canceled)15. The compound of claim 1 , wherein Ris substituted or unsubstituted Calkyl.16. (canceled)17. The compound of claim 1 , wherein l is 1 or 2.1821-. (canceled)22. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted Calkyl.2324-. (canceled)25. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted —CH-(piperazinyl).26. (canceled)27. The compound of claim 1 , wherein claim 1 , one Rgroup is haloalkyl.28. (canceled)29. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted imidazoyl.30. (canceled)31. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted piperazinyl.32. (canceled)33. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted morpholine.3437-. (canceled)39. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and optionally a pharmaceutically acceptable excipient.4043-. (canceled)44. A method of treating a B cell neoplasm in a subject comprising administering an effective amount of a compound of to the subject.4554-. (canceled)55. A kit comprising a ...

Display module, display device and working method thereof

A display module, a display device and a working method are provided. The display module includes a display panel; a grating structure, arranged on the light-emitting side of the display panel; a deformation unit, located between the display panel and the grating structure; a control circuit, configured to control the deformation unit to adjust a thickness of the deformation unit in a direction from the display panel to the grating structure to change a distance between the display panel and the grating structure.

METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA

The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplasm in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase. 57-. (canceled)1012-. (canceled)15. (canceled)17. The compound of claim 1 , wherein Ris substituted or unsubstituted Calkyl.18. (canceled)19. The compound of claim 1 , wherein l is 1.2023-. (canceled)24. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted Calkyl.2526-. (canceled)27. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted —CH-(piperazinyl).28. (canceled)29. The compound of claim 1 , wherein claim 1 , one Rgroup is haloalkyl.30. (canceled)31. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted imidazoyl.32. (canceled)33. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted piperazinyl.34. (canceled)35. The compound of claim 1 , wherein one Rgroup is substituted or unsubstituted morpholine.3639-. (canceled)41. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and optionally a pharmaceutically acceptable excipient.4245-. (canceled)46. A method of treating a B cell neoplasm in a subject comprising administering an effective amount of a compound of to the subject.4756-. (canceled)57. A kit comprising a container claim 1 , a compound of claim 1 , ...

HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES

Methods of treatment of conditions or diseases associated with myeloid differentiation primary response (MYD88) protein using a selective HCK inhibitor are provided herein. 2. The method of claim 1 , wherein the compound blocks ATP binding to HCK at a concentration at least 30-fold lower than the concentration at which it blocks ATP binding to BTK under equivalent conditions.3. The method of claim 1 , wherein the blocking of ATP binding to HCK and BTK is tested in a native protein kinase activity profiling assay performed under conditions described in Example 1.4. The method of claim 3 , wherein the compound blocks ATP binding to HCK at a concentration of 1 μM as determined by absence of a detectable band in the native protein kinase activity profiling assay performed under conditions described in Example 1.5. The method of claim 3 , wherein the compound does not block ATP binding to BTK at a concentration of 1 μM as determined by presence of a detectable band in the native protein kinase activity profiling assay performed under conditions described in Example 1.6. The method of claim 1 , wherein the pharmaceutical composition comprising the compound further blocks ATP binding to LYN at a concentration at least 10-fold lower than the concentration at which it blocks ATP binding to BTK under equivalent conditions.7. (canceled)8. The method of claim 6 , wherein the blocking of ATP binding to LYN and BTK is tested in a native protein kinase activity profiling assay performed under conditions described in Example 1.9. The method of claim 8 , wherein the compound blocks ATP binding to LYN at a concentration of 1 μM as determined by absence of a detectable band in the native protein kinase activity profiling assay performed under conditions described in Example 1.10. The method of claim 8 , wherein the compound does not block ATP binding to BTK at a concentration of 1 μm as determined by presence of a detectable band in the native protein kinase activity profiling assay ...

Vibratory treatment apparatus

Vibratory treatment apparatus including a first receptacle arranged to receive media for vibratory treatment of the article, the first receptacle defining a first aperture; and a first valve positioned at the first aperture of the first receptacle, the first valve being arranged to allow passage of the article there through and to prevent the flow of media through the first aperture.

THERMOSYPHON HEAT SINK

A heat-dissipating device includes a condenser and an evaporator. The condenser includes a shell and a main capillary wick. The shell has a chamber and a through hole communicating with the chamber. The main capillary wick is disposed in the chamber. The evaporator has an evaporating section, a gas conduit and a liquid conduit. The evaporating section has a gas cavity, and the liquid conduit communicating with the chamber and filling with a liquid. The liquid conduit having a hole communicating with the gas cavity is inserted in the gas conduit and the gas cavity. A stepped area is formed between the liquid conduit and the chamber for gathering the liquid flowing into the liquid conduit. 1. A heat-dissipating device for contacting with a heating element , comprising:a condenser comprising a shell having a chamber and a through hole communicating with the chamber, and a main capillary wick disposed in an inner surface of the chamber;an evaporator comprising an evaporating section having a gas cavity, a gas conduit communicating with the through hole, a liquid conduit having an end communicating with the chamber and filling with liquid, wherein the liquid conduit is inserted in the gas conduit and has a hole on a side facing the heating element for communicating with the gas cavity, and an outer surface of the evaporating section is contacted with the heating element, and a side of the liquid conduit is connected with an inner surface of the gas conduit, wherein the end of the liquid conduit communicating with the chamber is positioned in the through hole; andthe condenser and the evaporator are configured such that the liquid flows into the gas cavity and absorbs the heat generated from the heating element to be transformed into gas, the gas flows into the gas chamber through the gas conduit, the gas is transformed into the liquid; andwherein the evaporating section further include an auxiliary capillary wick, and the auxiliary capillary wick is connected with the ...

Use of Inhibitors of Acid Sphingomyelinase to Treat Acquired and Inherited Retinal Degenerations

A method of treating retinal diseases is disclosed that includes the step of administering an effective amount of a composition including an ASMase inhibitor to a retinal disease patient, wherein at least one disease symptom is either lessened or progression of the symptom is delayed. 1. A method of treating retinal diseases , comprising the step of:administering an effective amount of a composition comprising an ASMase inhibitor to a retinal disease patient,wherein at least one of a retinal disease symptom is lessened or progression of the symptom is delayed.2. The method of claim 1 , wherein the disease is associated with an abnormal accumulation of lipofuscin.3. The method of claim 1 , wherein the disease is selected from the group including age-related macular degeneration (AMD) claim 1 , Stargardt macular dystrophies claim 1 , Best vitelliform macular dystrophy claim 1 , and neuronal ceroid lipofuscinoses (NCLs).4. The method of claim 1 , wherein the ASMase inhibitor is desipramine.5. The method of claim 1 , wherein the composition is applied topically to the affected eye or eyes.6. The method of claim 1 , wherein the composition is applied in the following dose range: oral dose of between 10-100 mg/day or topical doses of between 0.1 mg and 1 mg/day.7. The method of claim 1 , wherein the progression of the following symptoms is delayed: accumulation of soft claim 1 , large drusen; fundus autofluorescence; and dark adaptation.8. A method of treating macular degeneration in a subject in need thereof claim 1 , comprising the steps of:identifying a subject with macular degeneration; andadministering to the subject a therapeutically effective amount of a composition comprising an inhibitor of acid sphingomyelinase activity.9. The method of claim 8 , wherein the macular degeneration is age-related macular degeneration.10. The method of claim 1 , wherein the ASMase inhibitor is selected from the group consisting of desipramine claim 1 , amitriptyline claim 1 , ...

MANUFACTURING METHOD OF HEAT CONDUCTING DEVICE

A manufacturing method of a heat conducting device includes following steps: providing a first plate, which includes a plate body and at least a heat conducting element, wherein the plate body has at least an inserting end disposed corresponding to the heat conducting element and defining a tube, and the heat conducting element is mounted at the tube; providing a second plate, which has a first opening end; disposing a first wick structure on an internal wall of the heat conducting element and a bottom surface of the plate body; disposing a second wick structure on an internal wall of the second plate; and connecting the plate body to the first opening end so as to connect the first plate and the second plate to form a chamber. Accordingly, the heat conducting device has a higher heat conducting efficiency. 1. A manufacturing method of a heat conducting device , comprising steps of:providing a first plate, wherein the first plate comprises a plate body and at least a heat conducting element, the plate body has at least an inserting end disposed corresponding to the heat conducting element and defining a tube, and the heat conducting element is mounted at the tube;providing a second plate, wherein the second plate has a first opening end;disposing a first wick structure on an internal wall of the heat conducting element and a bottom surface of the plate body;disposing a second wick structure on an internal wall of the second plate; andconnecting the plate body to the first opening end so as to connect the first plate and the second plate to form a chamber.2. The manufacturing method of claim 1 , wherein the heat conducting element is a heat pipe or a temperature plate.3. The manufacturing method of claim 1 , wherein the first plate is integrally formed as one piece.4. The manufacturing method of claim 1 , wherein the heat conducting element has a second opening end claim 1 , and the manufacturing method further comprises a step of:inserting the second opening end of ...