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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 6. Отображено 6.
19-08-2015 дата публикации

Tryptanthrin bromo derivative with antineoplastic activity and synthetic method therefor

Номер: CN104844607A
Автор: TAN MINGXIONG
Принадлежит:

The invention discloses a tryptanthrin bromo derivative with antineoplastic activity and a preparation method therefor. The tryptanthrin bromo derivation is 2,8-dibromo-tryptanthrin. The preparation method comprises the following steps: using tryptanthrin as a raw material, adding trifluoroacetic acid as a solvent, adding concentrated sulfuric acid as a catalyst after the tryptanthrin is dissolved, adding N-bromo-succinimide for reaction, reacting for 40-50 hours while controlling temperature to be 35-45 DEG C, cooling, standing, removing the trifluoroacetic acid, pouring reaction liquid into ice water to separate out light yellow solid, neutralizing, carrying out suction filtration, washing the light yellow solid with water, carrying out acetone washing, and drying, to obtain the 2,8-dibromo-tryptanthrin. The product has excellent antineoplastic activity, and can be applied to anti-lung cancer and anti-stomach cancer drugs.

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Номер записи: 1
08-09-2010 дата публикации

Metal complex using plumbagin as ligand, synthesizing method and usage thereof

Номер: CN0101037447B
Автор: YANG BIN, LIU HUAGANG, CHEN ZHENFENG, TAN MINGXIONG, LIANG HONG, WANG HENGSHAN, BIN YANG, HUAGANG LIU, ZHENFENG CHEN, MINGXIONG TAN, HONG LIANG, HENGSHAN WANG
Принадлежит:

The invention discloses a metal chelate which takes plumbagin as ligand, and the synthesis method and application thereof. The metal chelate is represented by the right formula, wherein, M represents the metal ion able to accept lone pair electrons can be main group matel ion, or transition metal ion, or rare earth metal ion such as Ca(II), Mg(II), Sn(IV), Cu(II), Co(II), Ni(II), Zn(II), Fe(II), Mn(II), Ag(I), Mo(VI), Pd(II), Ru(III), W(VI), Pt(II), Y(III), La(III), Nd(III), Sm(III), Eu(III), Er(III). The invention synthesizes a series of metal chelate which takes plumbagin as ligand and reacts with the metal salt. The produced chelate has an inhibition to a plurality of tumor line. The result indicates a plurality of chelate having a more remarkable anti-tumor activity than the plumbaginand have a higher medicine value and can be used for the preparation of different anti-tumor medicine.

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Номер записи: 2
18-02-2015 дата публикации

Preparation method of p-hydroxybenzaldehyde condensed isoniazide and application thereof

Номер: CN104356062A
Автор: DENG XU, LI DONGQING, TAN MINGXIONG, DENG PING, XIN GUIYU
Принадлежит:

The invention discloses a preparation method of p-hydroxybenzaldehyde condensed isoniazide and application thereof, and belongs to the field of plant disease control. According to the method, p-hydroxybenzaldehyde condensed isoniazide is utilized to research the inhibitory effect on cucumber damping-off fungi and phyricularia grisea by p-hydroxybenzaldehyde condensed isoniazide through a mycelial growth rate method. Agent concentration is set to be five gradients which are 1 microgram/ml, 2 microgram/ml, 4 microgram/ml, 6 microgram/ml and 8 microgram/ml to perform tests, the bacterial colony inhibitory effect is measured through the growth rate method, and the median lethal concentration EC50 and inhibition ratio of germs are obtained by processing diameter data of the bacterial colony. Being contrasted from the point of the EC50 value, the sensitive degree of germs on p-hydroxybenzaldehyde condensed isoniazide is cucumber damping-off fungi and phyricularia grisea. Experimental results ...

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Номер записи: 3
11-03-2015 дата публикации

Synthesis method for p-hydroxybenzaldehyde semicarbazone, and application of p-hydroxybenzaldehyde semicarbazone in plant disease control

Номер: CN104402771A
Автор: LI DONGQING, DENG XU, TAN MINGXIONG, LUO XUJIAN, GU YUNQIONG
Принадлежит:

The invention belongs to the field of plant disease control, and discloses a synthesis method for p-hydroxybenzaldehyde semicarbazone, and an application of the p-hydroxybenzaldehyde semicarbazone in plant disease control. The new medicament p-hydroxybenzaldehyde semicarbazone is prepared through semicarbazide hydrochloride and p-hydroxy benzaldehyde. Experiments of the invention prove that the newly synthesized medicament p-hydroxybenzaldehyde semicarbazone has remarkable inhibiting effect on corresponding pathogenic bacteria of rice blast and cucumber damping-off, and particularly has the best inhibiting effect on pathogenic bacteria of rice blast. The p-hydroxybenzaldehyde semicarbazone prepared through the invention can be well applied to the control of rice blast and cucumber damping-off.

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Номер записи: 4
09-06-2023 дата публикации

2-amino-8-hydroxyquinoline nickel complex for resisting drug-resistant ovarian cancer and preparation method of 2-amino-8-hydroxyquinoline nickel complex

Номер: CN116239635A
Автор: ZHOU ZHEN, DU LINGQI, QIN QIPIN, ZHU LIGANG, TAN MINGXIONG, MO DONGYIN, HUANG YAN, QIN FUQIONG, WANG XIAOBIN, MENG XIAOXIN
Принадлежит:

The invention discloses a 2-amino-8-hydroxyquinoline nickel complex for resisting drug-resistant ovarian cancer and a preparation method of the 2-amino-8-hydroxyquinoline nickel complex. According to the preparation method, 2-amino-8-hydroxyquinoline is taken as a first ligand, and 4, 7-dichloro-1, 10-phenanthroline, 5 '-dimethyl-2, 2'-dipyridyl, 5-chloro phenanthroline, 4, 4 '-dimethoxy-2, 2'-dipyridyl, 1, 10-phenanthroline-5-amino, 1, 10-phenanthroline, 2, 9-dimethyl phenanthroline (L7) and 4, 7-diphenyl-1, 10-phenanthroline are respectively taken as auxiliary ligands, so that the compound is prepared. According to the present invention, 8 novel 2-amino-8-hydroxyquinoline nickel complexes Ni-1-Ni-8 used for treating ovarian cancer drug-resistant strain cells are synthesized by using 2-amino-8-hydroxyquinoline as the raw material, and the experimental results show that Ni-1-Ni-8 has good inhibition effect on ovarian cancer drug-resistant strain cells SK-OV-3/DDP, has much less toxicity ...

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Номер записи: 5
25-02-2015 дата публикации

Preparation method and application of N, N'-bispyridine-4-formaldehydeazine

Номер: CN104370803A
Автор: LI DONGQING, DENG XU, TAN MINGXIONG, LUO XUJIAN, GU YUNQIONG
Принадлежит:

The invention discloses a preparation method and an application of N, N'-bispyridine-4-formaldehydeazine and belongs to the field of prevention and treatment of plant diseases. By N, N'-bispyridine-4-formaldehydeazine and a mycelial growth rate method, the inhibitory effects of N, N'-bispyridine-4-formaldehydeazine on cucumber damping-off pathogenic bacteria and pyricularia grisea are studied. The concentrations of chemical agent are set at five gradients, namely, 0, 2 mu g/ml, 4 mu g/ml, 6 mu g/ml, and 8mu g/ml for experiments, the inhibitory effects of bacterial colonies are measured by the growth rate method and the median lethal concentrations EC50 and the inhibition rates are obtained by processing the data of diameters of the bacterial colonies. Compared with angles of EC50 values, the reagent N, N'-bis-4-pyridineformaldehydeazine sequentially has greater bactericidal virulence on pyricularia grisea than cucumber damping-off pathogenic bacteria. Experimental results show that N, N ...

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Номер записи: 6