PHOSPHORYLATION MEANS, PROCEDURE FOR ITS PRODUCTION, PROCEDURE FOR THE PHOSPHORYLATION OF AN ORGANIC HYDROXYL OR AMINE CONNECTION.

PHOSPHORYLATING AGENTS AND PROCESS FOR PHOSPHORYLATING AN ORGANIC HYDROXYL OR AMINE COMPOUND

PHOSPHORYLATING AGENTS AND PROCESS FOR PHOSPHORYLATING AN ORGANIC HYDROXYL OR AMINE COMPOUND

NEW ACTH-ACTIVE PEPTIDES AND PROCESS FOR THEIR MANUFACTURE

Methods of determining endogenous thrombin potential (ETP) and thrombin substrates for use in said methods

A method for determining the endogenous thrombin potential of a sample having a total anticoagulant activity of or equivalent to at least 0.07 U ISH/ml, includes using a thrombin substrate or a salt thereof that is soluble in the sample to determine the ETP of the sample. Suitable thrombin substrate include those of the formula P-Val-Xaa-S, in which P is an amino protective group, that is non-aromatic and polar, Val is a valine residue attached via a peptide bond to Xaa, Xaa is an amino acid residue comprising a terminal guanidino group or ureido group separated by at least 2 carbon atoms from the peptide backbond the amino acid residue is attached to S and S is a signal group such as a chromophore that can be enzymatically hydrolyzed. Other substrates include substrates comprising the structure Zaa-Pipecolyl-Yaa-S or Zaa-Pro-Yaa-S, wherein Zaa represents D-Phenylalanine, D-Tryptophan or D-Tyrosine, Pro represents proline, Yaa is an amino acid residue other than arginine and S is a signal ...

PHOSPHORYLATING AGENT; A PROCESS FOR THE PREPARATION THEREOF; A PROCESS FOR PHOSPHORYLATING AN ORGANIC HYDROXYL OR AMINE COMPOUND