THERMOPLASTIC POLYURETHANE COMPOSITE MATERIAL COMPOSITION, THERMOPLASTIC POLYURETHANE COMPOSITE MATERIAL AND MANUFACTURING METHOD THEREOF, SHOE MATERIAL AND WEARABLE APPARATUS

A thermoplastic polyurethane composite material composition includes a plastic base material and a curing agent, the plastic base material includes a thermoplastic polyurethane and a silicone gum including at least two alkenyl groups in each of molecules thereof, wherein the thermoplastic polyurethane and the silicone gum are uniformly mixed, and a weight ratio of the thermoplastic polyurethane and the silicone gum is ranging from 95.01:4.99 to 99.5:0.5. The curing agent is uniformly mixed with the plastic base material, wherein the curing agent has an adding amount enabling the silicone gum to crosslink to form a silicone rubber. 1. A thermoplastic polyurethane composite material composition , comprising: a thermoplastic polyurethane; and', 'a silicone gum comprising at least two alkenyl groups in each of molecules thereof,', 'wherein the thermoplastic polyurethane and the silicone gum are uniformly mixed, and a weight ratio of the thermoplastic polyurethane and the silicone gum is ranging from 95.01:4.99 to 99.5:0.5; and, 'a plastic base material, comprisinga curing agent uniformly mixed with the plastic base material, wherein the curing agent has an adding amount enabling the silicone gum to crosslink to form a silicone rubber.2. The thermoplastic polyurethane composite material composition of claim 1 , wherein the curing agent is a peroxide.3. The thermoplastic polyurethane composite material composition of claim 1 , wherein the curing agent is a compound containing at least one silicon hydrogen bond.4. The thermoplastic polyurethane composite material composition of claim 1 , further comprising a platinum catalyst.5. The thermoplastic polyurethane composite material composition of claim 1 , further comprising a filler.6. A method for manufacturing a thermoplastic polyurethane composite material claim 1 , comprising:providing a mixing step, wherein a plastic base material and a curing agent are uniformly mixed, the plastic base material comprises a thermoplastic ...

Method for Providing a Side-Chain Dendrimer Vesicle

A method for making a side-chain dendrimer vesicle includes the following steps. At first, there is provided a random copolymer with a narrow distribution of molecular weights by active polymerization and chemical modification. Then, chemical modification is executed to graft various generations of dendrimers to the random copolymer to provide a side-chain dendritic random copolymer with various generations. Two steps of emulsification are taken to induce macromolecular self-assembling of the side-chain dendritic random copolymer solution to form the macromolecular vesicle. The side-chain dendrimer includes C 10 ˜C 18 hydrophobic alkyl chains.

Electrophoretic fluid

The present invention is directed to a display fluid comprising charged composite pigment particles dispersed in a solvent. The composite pigment particles have a density which matches to the density of the solvent in which they are dispersed. A display fluid comprising the composite pigment particles provides improved display performance.

METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM

The disclosure relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and/or the regulation of eyeball size. These drugs are potential candidates for treating myopia and/or keratoconus disease. 1. A method for treating a disease mediated by expression of lumican and/or collagen fibrillogenesis , and/or treating myopia and/or keratoconus disease , comprising administering to the subject a therapeutically effective amount of a MMP inhibitor.6. The method of claim 5 , wherein the compound is CL-82198 claim 5 , Marimastat claim 5 , or Batimastat.8. The method of claim 7 , wherein Ris H; Ris H claim 7 , —CH-pyrrolyl claim 7 , —CH—NH—CH—CH—CH—CH—CH(NH2)-COOH; Ris H or oxo; Ris H or OH; Ris H or OH and Ris NH claim 7 , N(CH)or halogen.10. The method of claim 9 , wherein the compound is Minocycline claim 9 , Tetracycline or doxycycline.17. A method for treating a disease medicated by expression of lumican and/or collagen fibrillogenesis claim 9 , and/or treating myopia and/or keratoconus disease claim 9 , comprising administering to the subject a therapeutically effective amount of a TGF-beta inhibitor.19. The method of claim 18 , wherein the TGF-beta inhibitor is Losartan claim 18 , N-acetylcysteine claim 18 , Propofol and Captopril.20. The method of claim 1 , wherein the method is for treating myopia.21. The method of claim 17 , wherein the method is for treating myopia. This application claims priority to U.S. Provisional Patent Application No. 61/649,611, filed on May 21, 2012, the disclosure of ...

COMPOSITION FOR EX VIVO CULTURING OF A CORNEAL ENDOTHELIAL CELL AND A METHOD FOR USING THE COMPOSITION

A composition for ex vivo culture of corneal endothelial cell and a method for used the composition are disclosed. The composition or the method is applied to ex vitro culture of the corneal endothelial cell to maintain the corneal endothelial cell in a hexagonal phenotype, and to prevent the corneal endothelial cell from endothelial-mesenchymal transformation (EnMT). Therefore, the corneal endothelial cell can maintain normal phenotype and function and can be used in the further application. The composition at least comprises an effective concentrated matrix metalloproteinase inhibitor (MMPI). 1. A growth regulator for ex vivo culturing of a corneal endothelial cell , at least comprises an effective concentrated matrix metalloproteinase inhibitor (MMPI). The regulator is added in the culture medium to maintain the phenotype and function of corneal endothelial cells and prevent the cells from endothelial-mesenchymal transformating and loss of function.2. The growth regulator as claimed in claim 1 , wherein the concentration of the MMPI is at least 1 uM.3. An inhibitor for preventing an ex vivo cultured corneal endothelial cell form endothelial-mesenchymal transformation claim 1 , at least comprises an effective matrix metalloproteinase inhibitor (MMPI). The inhibitor is added in the culture medium to maintain the phenotype and function of corneal endothelial cells and prevent the cells from endothelial-mesenchymal transformating and loss of function.4. The growth regulator as claimed in claim 3 , wherein the concentration of the MMPI is at least 1 uM.5. A method to prevent a corneal endothelial cells from endothelial-mesenchymal transformation comprising:obtaining the corneal endothelial cell from a donor;incubating the corneal endothelial cell in a corneal endothelial cell culture medium; andadding an effective concentration of matrix metalloproteinase inhibitor in a specific time point.6. The method as claimed in claim 5 , wherein the concentration of the MMPI is ...

DISPLAY MEDIUM AND MANUFACTURING METHOD THEREOF AND ELECTROPHORETIC DISPLAY THEREWITH

A display medium adapted for an electrophoretic display is provided. The display medium includes at least one particle and a random copolymer bonded with the particle, wherein the random copolymer has a structural unit originated from a first monomer and a second monomer. The first monomer is selected from at least one or a combination of a group of specific compounds consisting of 2-ethylhexyl acrylate, lauryl methacrylate and octadecyl acrylate etc. and the second monomer is selected from at least one kind of a group of specific compounds composed of 2,2,2 trifluoroethyl acrylate, 2,2,3,3 tetrafluoropropyl methacrylate and 1,1,1,3,3,3-hexafluoroisopropyl acrylate. A method of manufacturing the display medium and an electrophoretic display with the display medium are also provided. 1. A display medium , adapted for an electrophoretic display , the display medium comprising:at least one particle; anda random copolymer, bonded with the at least one particle, wherein the random copolymer includes a structural unit originated from a first monomer and a second monomer, wherein the first monomer is selected from at least one group consisting of 2-ethylhexyl acrylate (EHA), 2-ethylhexyl methacrylate (EHMA), 2-methylhexyl acrylate (MHA), 2-methylhexyl methacrylate (MHMA), lauryl methacrylate, lauryl acrylate, tetradecyl methacrylate, tetradecyl acrylate, hexadecyl methacrylate, hexadecyl acrylate, octadecyl mechacrylate, and octadecyl acrylate, and the second monomer is selected from at least one group consisting of 2,2,2 trifluoroethyl acrylate, 2,2,3,3 tetrafluoropropyl methacrylate, 1,1,1,3,3,3-hexafluoroisopropyl acrylate, 1,1,1,3,3,3-hexafluoroisopropyl methacrylate, 2,2,3,3,3-pentafluoropropyl acrylate, 2,2,3,3-tetrafluoropropyl acrylate, 2,2,3,4,4,4-hexafluorobutyl methacrylate, 2,2,3,3,4,4,4-heptafluorobutyl methacrylate, 2,2,3,3,4,4,5,5-octafluoropentyl acrylate, 2,2,3,3,4,4,5,5-octafluoropentyl methacrylate, 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl acrylate, ...

Timing control method and system applied on the network simulator platform

A timing control method and system applied on the network simulator platform are disclosed. When at least one subprocess calls a system call to enter a blocking I/O, a marking operation is performed, the kernel issues a first notification event to a network simulator, to request the network simulator to pause until the subprocess leaves from the blocking I/O. when the kernel detects that the subprocess leaves from the blocking I/O already, the kernel issues a second notification event to the network simulator, so that the network simulator continues to simulate. The present invention can control the subprocess to not continuously occupy resource, and first and second notification events can prevent a simulator timer from continuously running during the subprocess execution period, to cause an abnormal timing of a simulation result.

DISPLAY

A display includes a display medium layer and a dielectric layer disposed at a side of the display medium layer. The composition of the dielectric layer includes at least a humectant for decreasing the electric resistivity of the dielectric layer and stabilizing the electric performance of the display.

Method for Providing a Side-Chain Dendrimer Vesicle

A method disclosed for making a side-chain dendrimer vesicle. The method includes the steps of: At first, there is provided a random copolymer with a narrow distribution of molecular weights by active polymerization and chemical modification. Then, chemical modification is executed to graft various generations of dendrimers to the random copolymer to provide a side-chain dendritic random copolymer with various generations. Two steps of emulsification are taken to induce macromolecular self-assembling of the side-chain dendritic random copolymer solution to form the macromolecular vesicle. The side-chain dendrimer includes C 10 ˜C 18 hydrophobic alkyl chains.

ELECTROPHORETIC FLUID

A red particle for an electrophoretic display. The particle includes a core of a diketopyrrolopyrrole pigment, a shell around the core comprising a methacrylate, and steric siloxane molecules extending from the shell. 1. A particle comprising:a core comprising a diketopyrrolopyrrole pigment;a shell substantially surrounding the core and comprising a methacrylate polymer; andsteric polymers comprising a polysiloxane coupled to or absorbed by the shell,wherein the combined weight of the methacrylate and the polysiloxane is between 30% and 70% of the total weight of the particle.2. The particle of claim 1 , wherein the diketopyrrolopyrrole pigment is 3 claim 1 ,6-Bis(4-chlorophenyl)pyrrolo[3 claim 1 ,4-c]pyrrole-1 claim 1 ,4(2H claim 1 , 5H)-dione.3. The particle of claim 1 , wherein the methacrylate poly comprises methyl methacrylate.4. The particle of claim 1 , wherein the polysiloxane comprises dimethylsiloxane.5. The particle of claim 1 , wherein the combined weight of the methacrylate and the polysiloxane is between 40% and 60% of the total weight of the particle.6. A display fluid comprising a particle of . This application is a continuation-in-part of U.S. patent application Ser. No. 15/163.926, filed May 25, 2016, which is a continuation of U.S. patent application Ser. No. 13/549,028, filed Jul. 13, 2012; now U.S. Pat. No. 9,372,380, which is a continuation-in-part of U.S. patent application Ser. No. 13/363,741, filed Feb. 1, 2012; now U.S. Pat. No. 9,366,935, which claims priority to U.S. Provisional Application No. 61/439,302, filed Feb. 3, 2011; the contents of the above applications are incorporated herein by reference in their entireties.The present invention is directed to the preparation of composite pigment particles that can be used to form an electrophoretic fluid and the resulting display fluid.An electrophoretic display (EPD) is a non-emissive device based on the electrophoresis phenomenon influencing charged pigment particles dispersed in a ...

Electrophoretic fluid

The present invention is directed to a display fluid comprising charged composite pigment particles dispersed in a solvent. The composite pigment particles have a density which matches to the density of the solvent in which they are dispersed. A display fluid comprising the composite pigment particles provides improved display performance.

Methods for drug screen using zebrafish model and the compounds screened therefrom

本發明係關於一種以斑馬魚近視實驗篩選治療及/或預防近視及錐狀角膜疾病之候選藥物之平台。本發明主要係以透明蛋白(Lumican)、數種富含白氨基酸小多醣蛋白家族(small leucine-rich proteoglycan,SLRP)之一為基礎，其係於膠原纖維生成或影響斑馬魚眼球軸長之基因之調控上扮演重要角色，另外，亦於臨床近視上扮演重要角色。據此，本發明係採用所建立之斑馬魚近視實驗模組，進一步鑑定影響透明蛋白及膠原蛋白原纖維生成之表現之藥物、及/或影響眼球軸長及/或錐狀角膜疾病之調控之藥物。該等藥物係治療近視及/或錐狀角膜疾病之具潛力之候選藥物。

Thermoplastoc polyurethane composite material, shoe material, head-mounted display and smart watch

A thermoplastic polyurethane composite material composition includes a plastic base material and a curing agent, the plastic base material includes a thermoplastic polyurethane and a silicone gum including at least two alkenyl groups in each of molecules thereof, wherein the thermoplastic polyurethane and the silicone gum are uniformly mixed, and a weight ratio of the thermoplastic polyurethane and the silicone gum is ranging from 95.01:4.99 to 99.5:0.5. The curing agent is uniformly mixed with the plastic base material, wherein the curing agent has an adding amount enabling the silicone gum to crosslink to form a silicone rubber.

Display medium and fabricating method thereof and electrophoretic display therewith

一種顯示介質，適用於一電泳顯示器中，此顯示介質包含至少一粒子以及一與粒子鍵結之無規共聚物，其中無規共聚物具有為來源於一第一單體以及一第二單體的結構單元。第一單體選自於丙烯酸-2-乙基己酯、甲基丙烯酸月桂酯以及丙烯酸十八烷基酯等特定化合物所組成之群組中的至少一種，且第二單體選自於2,2,2-丙烯酸三氟乙酯、2,2,3,3-四氟丙基酯以及1,1,1,3,3,3-丙烯酸六氟異丙基酯等特定化合物所組成之群組中的至少一種。一種上述顯示介質的製造方法以及其所適用之電泳顯示器亦被提出。

Honeycomb-like polymeric films base on dendritic side-chain polyurethane

Method for providing a side-chain dendrimer vesicle

A method disclosed for making a side-chain dendrimer vesicle. The method includes the steps of: At first, there is provided a random copolymer with a narrow distribution of molecular weights by active polymerization and chemical modification. Then, chemical modification is executed to graft various generations of dendrimers to the random copolymer to provide a side-chain dendritic random copolymer with various generations. Two steps of emulsification are taken to induce macromolecular self-assembling of the side-chain dendritic random copolymer solution to form the macromolecular vesicle. The side-chain dendrimer includes C 10 ˜C 18 hydrophobic alkyl chains.

Dendron, polyurethane with side-chain regular dendron, and producing methods thereof

A dendron with hydrophobic functional of end group, a polyurethane with the dendron, and producing methods thereof are disclosed. The dendron with hydrophobic functional of end group in the polyurethane systems, and the honeycomb-like structure thin films were obtained by a breath-figure process. The structures of dendron and dendritic side-chain polyurethanes are respectively expressed in the following. Therein, the end-groups (R) of the dendron are long alkyl chains or perfluoroalkyl derivatives.

Electrophoretic fluid

The present invention is directed to a display fluid comprising charged composite pigment particles dispersed in a solvent. The composite pigment particles have a density which matches to the density of the solvent in which they are dispersed. A display fluid comprising the composite pigment particles provides improved display performance.