Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

Use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range. 1. A method of predicting heat exhaustion or heat stroke in an ambulatory mammal , comprising:at least periodically measuring sound emanating from an airflow through the mammal's trachea with an acoustic measurement device, the acoustic measurement device including a housing including a sound transducer and a temperature sensor;correlating the measured sound into a measurement of the mammal's respiratory rate and tidal volume;assigning a first value of a likelihood of at least one of heat exhaustion and heat stroke to the measured respiratory rate and a second value to the likelihood of at least one of heat exhaustion and heat stroke to tidal volume;at least periodically measuring the mammal's temperature;assigning a third value of a likelihood of at least one of heat exhaustion and heat stroke to the measured temperature; andgenerating at least one from the group consisting of an alert and an alarm if a comparison of the first value, second value, and third value exceeds a predetermined range.2. The method of claim 1 , further comprising multiplying at least one from the group consisting of the first value claim 1 , the second value claim 1 , and the third value by a predetermined weighting value.3. The method of claim 1 , wherein the housing of the acoustic measurement device has a width between 0.5 cm and 2.5 cm.4. The method of claim 1 , wherein the housing defines an opening claim 1 , and wherein positioning the acoustic measurement device on the skin of the mammal includes pressing the opening of the ...

Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range. 1. A method of predicting an opioid overdose with an acoustic measurement device , the acoustic measurement device having a sound transducer , the sound transducer configured to measure sound associated with airflow through a mammalian trachea , the method comprising:correlating the measured sound into a measurement of tidal volume; andgenerating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range, the at least one of the alert and the alarm indicating a likelihood of an opioid overdose.2. The method of claim 1 , wherein the measurement of sound associated with airflow through the trachea occurs at least periodically.3. The method of claim 1 , wherein the acoustic measurement device includes a housing claim 1 , and wherein the sound transducer is suspended within the housing.4. The method of claim 3 , wherein the housing of the acoustic measurement device has a width between 0.5 cm and 2.5 cm.5. The method of claim 3 , wherein the housing defines an opening claim 3 , and wherein the sound transducer is disposed on an end of the housing opposite the opening.6. The method of claim 3 , wherein the housing is configured to releasably couple to skin of the mammalian trachea.7. The method of claim 6 , wherein the housing includes a diaphragm configured to vibrate in response to sound.8. The method of claim 7 , wherein the housing is configured to engage coupling component releasably adhered to the skin claim 7 , and wherein the ...

USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. 5. The pharmaceutical composition of claim 1 , wherein the composition is formulated for oral administration claim 1 , intravenous administration claim 1 , or intramuscular injection.6. The pharmaceutical composition of claim 1 , wherein the composition is a solution and contains from about 0.05 mg/ml to about 0.5 mg/ml.7. The pharmaceutical composition of claim 1 , wherein the composition is formulated as an oral dosage form containing about 0.2 mg to about 500 mg of the compound.11. A compound or salt of claim 9 , wherein{'sub': '1', 'Ris hydrogen or hydroxyl;'}{'sub': '3', 'Ris hydrogen or methyl;'}{'sub': 4', '5', '1', '2', '1', '2, 'Rand Rare each 0 to 2 substituents independently chosen from halogen, hydroxyl, amino, C-Calkyl, and C-Calkyl; and'}{'sub': '6', 'Ris hydrogen or methyl.'}12. A compound or salt of claim 11 , wherein{'sub': 2', '2', '2', '2', '2', '6', '6', '2', '1', '6', '2', '4', '0', '2', '3', '7', '0', '4', '0', '2', '0', '2', '2', '1', '4', '1', '4', '1', '6', '1', '4', '1', '2', '1', '2, 'Ris -ABwhere Ais a bond, —(C═O)O—, —S(O)—, —(S═O)NR—, or —(C═O)NR—, Bis C-Calkyl, C-Calkanoyl, (phenyl)C-Calkyl, (C-Ccycloalkyl)C-Calkyl, (heterocycloalkyl)C-Calkyl, (5- or 6-membered heteroaryl)C-Calkyl, or an amino acid covalently bound to Aby its C-terminus, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C-Calkyl, C-Calkoxy, C-Calkylester, mono- and di-(C-Calkyl)amino, C-Chaloalkyl, and C-Chaloalkoxy.'}13. A compound or salt of claim 12 , wherein{'sub': 2', '2', '2, 'Ais a bond and Bis an amino acid covalently bound to Aby its C-terminus.'}15. A compound or salt of claim 11 , where{'sub': 2', '2', '2', '6', '2', '3', '7', '0', '4', '1', '4', '1', '4', '1', '4, 'Ais a bond or —(C═O)O— and Bis C- ...

THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment. 57-. (canceled)11. A compound or salt of claim 9 , wherein{'sub': '1', 'Ris hydrogen or hydroxyl;'}{'sub': '3', 'Ris hydrogen or methyl;'}{'sub': 4', '5', '1', '2', '1', '2, 'Rand Rare each 0 to 2 substituents independently chosen from halogen, hydroxyl, amino, C-Calkyl, and C-Calkyl; and'}{'sub': '6', 'Ris hydrogen or methyl.'}12. A compound or salt of claim 11 , wherein{'sub': 2', '2', '2', '2', '2', '6', '6', '2', '1', '6', '2', '4', '0', '2', '3', '7', '0', '4', '0', '2', '0', '2', '2', '1', '4', '1', '4', '1', '6', '1', '4', '1', '2', '1', '2, 'Ris -ABwhere Ais a bond, —(C═O)O—, —S(O)—, —(S═O)NR—, or —(C═O)NR—, Bis C-Calkyl, C-Calkanoyl, (phenyl)C-Calkyl, (C-Ccycloalkyl)C-Calkyl, (heterocycloalkyl)C-Calkyl, (5- or 6-membered heteroaryl)C-Calkyl, or an amino acid covalently bound to Aby its C-terminus, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C-Calkyl, C-Calkoxy, C-Calkylester, mono- and di-(C-Calkyl)amino, C-Chaloalkyl, and C-Chaloalkoxy.'}1314-. (canceled)15. A compound or salt of claim 11 , where{'sub': 2', '2', '2', '6', '0', '2', '3', '7', '0', '4', '1', '4', '1', '4', '1', '4, 'Ais a bond or —(C═O)O— and Bis C-Calkyl, (phenyl)C-Calkyl, or (C-Calkyl)C-Calkyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C-Calkyl, C-Calkoxy, and mono- ...

ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range. 1. A method of predicting heat exhaustion or heat stroke in an ambulatory mammal , comprising:periodically measuring sound emanating from an airflow through the mammal's trachea with an acoustic measurement device, the acoustic measurement device including a housing including a sound transducer and a temperature sensor;correlating the measured sound into a measurement of the mammal's respiratory rate and tidal volume;assigning a first value of a likelihood of at least one of heat exhaustion and heat stroke to the measured respiratory rate and a second value to the likelihood of at least one of heat exhaustion and heat stroke to tidal volume;periodically measuring the mammal's temperature;assigning a third value of a likelihood of at least one of heat exhaustion and heat stroke to the measured temperature; andgenerating at least one from the group consisting of an alert and an alarm if a comparison of the first value, second value, and third value exceeds a predetermined range.2. The method of claim 1 , further comprising multiplying at least one from the group consisting of the first value claim 1 , the second value claim 1 , and the third value by a predetermined weighting value.3. The method of claim 1 , wherein the housing of the acoustic measurement device has a width between 0.5 cm and 2.5 cm.4. The method of claim 1 , wherein the housing defines an opening claim 1 , and wherein positioning the acoustic measurement device on the skin of the mammal includes pressing the opening of the housing against the ...

Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range. 1. A method of determining acute respiratory distress with an acoustic measurement device , the acoustic measurement device including a sound transducer , the sound transducer being configured to measure sound emanating from an airflow through a mammalian trachea , the method comprising:correlating the measured sound into a measurement of the mammals' respiratory rate and tidal volume;calculating a minute ventilation based on the measured respiratory rate and tidal volume;measuring the mammal's heart rate, blood oxygen saturation, and temperature;comparing the calculated minute ventilation and measured heart rate, blood oxygen saturation, and temperature against respective predetermined thresholds;assigning a respective risk score for acute respiratory distress to each of the calculated minute ventilation and measured heart rate, blood oxygen saturation, and temperature based on the comparison;calculating a total risk score based on a sum of the respective risk scores; andgenerating at least one alert if the total risk score deviates from at least one predetermined total risk threshold for acute respiratory distress.2. The method of claim 1 , wherein the predetermined threshold for minute ventilation is whether the calculated minute ventilation is within a predetermined normal range.3. The method of claim 1 , wherein the predetermined threshold for heart rate is less than 50 beats per minute or greater than 100 beats per minute.4. The method of claim 1 , wherein the predetermined threshold for temperature is ...

Use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)-ketamine in the treatment of depression and neuropathic pain

The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

Non-Invasive Method and System of Signaling a Hyper or Hypoglycemic State

A method and system for determining a hyper or hypoglycemic state in a diabetic patient using acetone concentration in exhaled breath by means of a nasal device containing an acetone sensor. When a hyper or hypoglycemic state is detected, an alarm is issued. The alarm can be audible and/or can be sent wirelessly to a local or remote computer system.

Implantable drug delivery catheter system with capillary interface

The present invention relates to a drug delivery device which is implantable within a mammal and adapted for long-term efficient drug delivery to surrounding tissue. The drug delivery device is part of a drug delivery system that includes a catheter and a drug feed system. The drug delivery device includes a support structure that defines a drug reservoir and a capillary interface which facilitates vascular ingrowth while inhibiting blockage of drug delivery openings in the reservoir.

Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

Acoustic sensor and ventilation monitoring system

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

The use of (2r, 6r)-hydroxynorketamine and other stereoisomeric hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain

The use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Use of (2R, 6R)-hydroxynorketamine, (S)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (R,S)-ketamine in the treatment of depression and neuropathic pain

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Use of (2R, 6R)-hydroxynorketamine, (S)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (R,S)-ketamine in the treatment of depression and neuropathic pain

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.