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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 961. Отображено 100.
16-02-2012 дата публикации

Water resistant cementitious article and method for preparing same

Номер: US20120040168A1
Принадлежит: United States Gypsum Co

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

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26-07-2012 дата публикации

Pharmaceutical compositions based on anticholinergics and corticosteroids

Номер: US20120189556A1

A pharmaceutical composition comprising an anticholinergic and a steroid, optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the steroid optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of respiratory tract diseases.

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04-04-2013 дата публикации

Automatically generating a business process flow gui using a symbolic annotation language

Номер: US20130086491A1
Принадлежит: Oracle International Corp

A method, system, and computer program product for displaying an automatically generated graphical display of a business process flow to facilitate user interaction with enterprise software applications. A compact symbolic annotation language is used in conjunction with a flow generator to automatically generate a computer renderable description of the business process flow. The method commences by defining symbols to form an alphabet to be used in the symbolic annotation language. The compact symbolic language is capable of representing rich semantics including process operations, fork operations, and join operations. Once an agent (e.g., a person, a computer agent) has captured a particular business process flow using symbols of the compact symbolic annotation language, then a computer process performs a mapping of the symbols to a markup language. The markup language can be rendered in a graphical display. The markup language can be HTML/CSS, SVG, UML, or another markup language.

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25-07-2013 дата публикации

Combinations of medicaments for the treatment of respiratory diseases

Номер: US20130189194A1
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R 1 is hydrogen, halogen, C 1-4 -alkyl, or O—C 1-4 -alkyl; R 2 is hydrogen, halogen, C 1-4 -alkyl, or O—C 1-4 -alkyl; and R 3 is hydrogen, C 1-4 -alkyl, OH, halogen, O—C 1-4 -alkyl, O—C 1-4 -alkylene-COOH, or O—C 1-4 -alkylene-COO—C 1-4 -alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

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06-02-2014 дата публикации

Enhanced partially-aminated metal-organic frameworks

Номер: US20140033920A1
Принадлежит: Dow Global Technologies LLC

Described is an enhanced partially-aminated metal-organic framework comprising, or prepared from, metal cations and a synergistically effective ratio of a multi-carboxylic acid and an amino-substituted derivative of the multi-carboxylic acid, or the acceptable salts thereof, or any combination thereof; a manufactured article comprising the enhanced partially-aminated metal-organic framework; a method of preparing the enhanced partially-aminated metal-organic framework, and a method of using the enhanced partially-aminated metal-organic framework for separating carbon dioxide gas or other acid gas from an ad rem gas mixture.

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10-01-2019 дата публикации

Fixation for implantable medical devices

Номер: US20190009078A1
Принадлежит: MEDTRONIC INC

A tine portion of an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from a distal end of the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, for example, defined by a single radius, preferably tapers from a first width thereof, in proximity to a proximal end thereof, to a smaller, second width thereof, in proximity to the distal end thereof, wherein the tip has a width that is greater than the second width of the hook segment. Alternately, the tine portion may include a hook segment that is defined by two radii and a straight section extending therebetween.

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15-02-2018 дата публикации

Medical product and method for eliminating symptoms of nicotine withdrawal

Номер: US20180042912A1
Принадлежит: Individual

In essence, the present invention relates to a medical product including between about 94% and about 98% of a saline solution, preferably a normal saline solution containing about 0.9% sodium chloride dissolved in water, about ⅛ th of 1 milligram of relatively pure nicotine and about 3 milligrams of relatively pure nicotine. The medical product also includes about 1% and 3% of one or more flavors selected from the group consisting of citrus, tobacco, apple, cherry, maple, menthol, hazelnut, peach, lemon, vanilla and chocolate and 1% citric acid for taste. In addition, the medical product includes about 1% to 2% of ethyl alcohol for cleaning a micron mesh grid that generates particles of pure nicotine of from 2 to 5 microns that are drawn through an entrainment port, through a capsule containing the medical product through the micron mesh grid and into the individual's lungs and into their bloodstream.

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15-02-2018 дата публикации

Biaryl compositions and methods for modulating a kinase cascade

Номер: US20180042934A1
Принадлежит: Athenex Inc

The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

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13-02-2020 дата публикации

Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy

Номер: US20200046740A1
Принадлежит: Lunella Biotech Inc

The present disclosure relates to inhibitors of mitochondrial function. Methods of treating hypoxic cancer cells using anti-angiogenic agents and mitochondrial biogenesis inhibitors are disclosed. Tetracyclines, such as doxycycline, may serve as mitochondrial biogenesis inhibitors. Also described are methods of sensitizing hypoxic cancer cells to one or more chemotherapies by administering a mitochondrial biogenesis inhibitor with the chemotherapy.

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21-02-2019 дата публикации

Replacement heart valve commissure assembly

Номер: US20190053896A1
Принадлежит: Boston Scientific Scimed Inc

A replacement heart valve commissure assembly may include a locking mechanism including a first locking portion spaced apart from a second locking portion in a delivery configuration and configured to engage with the second locking portion in a deployed configuration, wherein the first locking portion is longitudinally actuatable relative to the second locking portion between the delivery and deployed configurations. The commissure assembly may include a first valve leaflet and a second valve leaflet each secured to the first locking portion. A first sleeve portion of the first valve leaflet may be fixedly attached to a first fabric sleeve wrapped around a first leg of the first locking portion by a first filament, and a second sleeve portion of the second valve leaflet may be fixedly attached to a second fabric sleeve wrapped around a second leg of the first locking portion by a second filament.

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02-03-2017 дата публикации

User-Configured Restrictions for Accessing Online Accounts Via Different Access Methods

Номер: US20170063925A1
Принадлежит: Bank of America Corp

According to one embodiment, a system includes a memory comprising instructions, an interface, and a processor communicatively coupled to the memory and the interface. The interface is configured to receive one or more account access rules, the account access rules comprising restrictions on accessing an online account through one or more access methods, and receive, via a first access method, a request to access the online account. The processor is configured, when executing the instructions, to determine, based on the account access rules, whether the online account may be accessed using the first access method.

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17-03-2016 дата публикации

Caveolin-1 related methods for treating glioblastoma with temozolomide

Номер: US20160074389A1
Автор: Michael P. Lisanti
Принадлежит: THOMAS JEFFERSON UNIVERSITY

This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temoxolomide to be glioblastoma multiforme-afflicted subject, wherein the subject's glioblastoma multiforme cells are known to be caveolin-1-positive. This invention also provides a method for determining whether a subject afflicted with glioblastoma multiforme is likely to progress therapeutically in response to a therapeutically effective regimen of temoxolomide comprising determining whether the subject's glioblastoma multiforme cells are caveolin-1-positive, whereby if the subject's glioblastoma multiforme cells are caveolin-1-positive, the subject is likely to progress therapeutically in response to a therapeutically effective regimen of temozolomide.

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12-05-2022 дата публикации

Systems and Temporal Alignment Methods for Evaluation of Gestational Age and Time to Delivery

Номер: US20220142477A1
Принадлежит: Leland Stanford Junior University

Methods to compute gestational age and time to delivery utilizing temporal alignment methods and applications thereof are described. Generally, systems utilize analyte measurements collected at one or more time points to determine a gestational age and time to delivery, which can be used as a basis to perform interventions and treat individuals. Computational models trained utilizing temporal alignment of analyte measurements can be used to determine gestational age and time to delivery.

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02-06-2022 дата публикации

Materials that Resist Fouling and Methods for Identifying Same

Номер: US20220169865A1
Принадлежит: Massachusetts Institute of Technology

In general, the present invention is directed to materials that when in use resist fouling on their surfaces. Such materials may be used in the construction of various process equipment having surfaces exposed to a given fluid that contains a foulant or chemical substance that may deposit on, or adhere to, the surface and thereafter continue to grow on the surface resulting in deteriorated performance of the equipment and process. The materials are specifically selected using a method that takes into account the dielectric spectra of the fluid to which the surface is exposed and the surface itself. It has been unexpectedly found that if the dielectric spectra of the surface and the fluid are matched to within relative agreement, there should be no adhesion of the foulant on the surface. In some embodiments, the dielectric spectra to be matched include the intrinsic indexes of refraction.

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29-04-2021 дата публикации

Composite based leading edge kit for a pool and/or spa cover system

Номер: US20210123254A1
Автор: Michael P. Prior
Принадлежит: Priority Electric Inc

Provided is a pool and/or spa cover leading edge kit for use with a pool and/or spa cover system. The kit includes at least two annular shaped fiber reinforced polymer composite segments capable of being axially aligned and interconnected at their abutting ends with each annular shaped fiber reinforced polymer composite segment having an axial length of from 3 feet to 20 feet. The kit also includes at least one joiner capable of interconnecting together a pair of abutting axially aligned annular shaped fiber reinforced polymer composite segments at their axial ends to form a segmented leading edge with an overall axial length of from 6 feet to 50 feet that is capable of being coupled to a pool and/or spa cover. The at least two annular shaped fiber reinforced polymer composite segments of the segmented leading edge include at least one of continuous fibers or discontinuous fibers oriented at least partially in the axial direction and encapsulated by a thermoset or thermoplastic resin matrix. After installation on the pool or spa, the segmented leading edge provides a deflection across the width of the pool or spa of from 0 to less than or equal to 0.10 inches per 10 feet of width of the pool or spa, and has a linear weight per foot of from 4 to 14 ounces per foot of axial length.

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02-05-2019 дата публикации

Biaryl compositions and methods for modulating a kinase cascade

Номер: US20190125754A1
Принадлежит: Athenex Inc

The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

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07-08-2014 дата публикации

Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm

Номер: US20140221496A1
Принадлежит: THOMAS JEFFERSON UNIVERSITY

The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.

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24-06-2021 дата публикации

Gait data collection and analytics system and methods for operating unweighting training systems

Номер: US20210187347A1
Принадлежит: AlterG Inc

Described herein are fields of exercise or therapy systems in particular exercise or therapy systems that controllably generate and maintain an unweighted environment using a mechanical system or a differential air pressure (DAP) envelope about a user so as to at least partially or completely unweight the user. This application also relates to improved control systems for pressure chambers for use in differential air pressure (DAP) systems including data collection and utilization for general fitness use, athletic use, or medical use treadmills and related software, control and analytics systems, especially as related to obtaining gait data from load cells provided in the system.

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30-07-2015 дата публикации

System and method for cardiac valve repair and replacement

Номер: US20150209139A1
Принадлежит: Cephea Valve Technologies Inc

A prosthetic mitral valve comprising an expandable anchor comprising a first anchor, a central portion and a second anchor; wherein the first anchor comprises a first outer frame and a second outer frame, the first outer frame comprising a plurality of first arcs joined together, and the second outer frame comprising a plurality of second arcs joined together, wherein the plurality of first arcs are out of phase relative to the plurality of second arcs when the first anchor is viewed in an end view from the first anchor to the second anchor; and a plurality of replacement leaflets secured to the expandable anchor.

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19-07-2018 дата публикации

Industrial vehicle armrest

Номер: US20180201165A1
Принадлежит: Crown Equipment Corp

An armrest includes an upper support section having one or more ventilation and drainage apertures that couple an upper surface of the upper support section to a lower portion of the armrest to facilitate airflow and drainage between the upper surface of the upper support section and the lower portion of the armrest. The armrest also includes one or more control implements and an arm pad removably coupled to the upper support section. The arm pad includes one or more pad apertures formed therein that communicate with the ventilation and drainage apertures to allow ventilation and drainage between an upper surface of the arm pad and the lower portion of the armrest.

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04-07-2019 дата публикации

System and method for cardiac valve repair and replacement

Номер: US20190201196A1
Принадлежит: Cephea Valve Technologies Inc

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

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27-08-2015 дата публикации

Msf reprograms myofibroblasts toward lactate production and fuel anaerboic tumor growth

Номер: US20150240240A1
Автор: Michael P. Lisanti
Принадлежит: THOMAS JEFFERSON UNIVERSITY

Presented herein is a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an agent that inhibits the MSF/Cdc42/NFkB cascade in the subject's tumor-associated fibroblasts.

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09-09-2021 дата публикации

Azithromycin and roxithromycin derivtives as senolytic drugs

Номер: US20210275560A1
Принадлежит: Lunella Biotech Inc

This disclosure describes the use of azithromycin, roxithromycin, and telithromycin, including derivatives thereof, as senolytic drugs. BrdU was used to induce senescence in model human fibroblast cell lines. Also disclosed are methods for screening compounds for senolytic activity. The SRB assay was used to measure cell viability through protein content. Azithromycin roxithromycin, and telithromycin, clinically-approved pharmaceuticals, were found to be senolytic drugs. However, the closely-related parent compound, erythromycin, showed no senolytic activity. Azithromycin strongly induced both aerobic glycolysis and autophagy in human fibroblasts, but showed bi-phasic effects including on mitochondrial oxygen consumption rates with inhibitory activity at 50 μM and stimulatory activity at 100 μM. The xCELLigence real-time assay system showed that azithromycin preferentially targets senescent cells, removing approximately 97% (nearly a 25-fold reduction in senescent cells).

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13-08-2020 дата публикации

Companion diagnostics for mitochondrial inhibitors

Номер: US20200255902A1
Принадлежит: Lunella Biotech Inc

The present disclosure relates to methods of identifying patients that may be responsive to mitochondrial inhibitor therapies to target and eradicate cancer stem cells. Also described are diagnostic kits that may be used to identify patients responsive to mitochondrial inhibitor therapies.

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11-11-2021 дата публикации

Biaryl piperidine amide compounds and methods of use thereof

Номер: US20210347763A1
Принадлежит: Athenex Inc

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

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01-11-2018 дата публикации

Replacement heart valve implant with invertible leaflets

Номер: US20180311036A1
Принадлежит: Boston Scientific Scimed Inc

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

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14-12-2017 дата публикации

Method and apparatus for limiting access to data by process or computer function with stateless encryption

Номер: US20170357786A1
Принадлежит: PULSELOCKER Inc

Systems and methods related to DRM content usage mechanisms for both online and offline usage of content are disclosed, including systems providing secure access to data regardless of network state or connectivity state to the networked access control mechanism. An access control mechanism having a secondary offline access control mechanism is presented, further including multiple implementations for data encapsulation, as well as providing a method for writes to files and to the filesystem itself by externally created applications with no API or modification to their operation.

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22-12-2016 дата публикации

Method and apparatus for limiting access to data by process or computer function with stateless encryption

Номер: US20160371472A1
Принадлежит: PULSELOCKER Inc

Systems and methods related to DRM content usage mechanisms for both online and offline usage of content are disclosed, including systems providing secure access to data regardless of network state or connectivity state to the networked access control mechanism. An access control mechanism having a secondary offline access control mechanism is presented, further including multiple implementations for data encapsulation, as well as providing a method for writes to files and to the filesystem itself by externally created applications with no API or modification to their operation.

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03-12-2020 дата публикации

Triphenylphosphonium-derivative compounds for eradicating cancer stem cells

Номер: US20200376008A1
Принадлежит: Lunella Biotech Inc

Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signaling in living cells. TPP-related compounds may be utilized to target mitochondria in cancer stem cells (CSCs), and may be used for treating and/or preventing tumor recurrence, metastasis, drug resistance, and/or radiotherapy resistance, as well as for anti-cancer therapies. Various TPP-related compounds validated for oxygen consumption inhibition (OCR), were non-toxic, and had little or no effect on ATP production in normal human fibroblasts. Yet these compounds selectively target adherent “bulk” cancer cells. These compounds also inhibit the propagation of CSCs in suspension. TPP-related compounds provide a novel chemical strategy for effectively targeting both i) “bulk” cancer cells and ii) CSCs, while specifically minimizing or avoiding off-target side-effects in normal cells, among other useful therapies.

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04-12-2018 дата публикации

Devices, systems and methods including magnetic structures

Номер: US10145906B2
Принадлежит: Analog Devices Global ULC

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

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17-07-1997 дата публикации

Antithrombotic diamines

Номер: WO1997025033A1
Принадлежит: ELI LILLY AND COMPANY

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula (I).

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13-07-2021 дата публикации

Magnetic device with magnetic structure and micro-fluidic structure

Номер: US11061086B2
Принадлежит: Analog Devices Global ULC

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

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30-05-2002 дата публикации

Stylus input device utilizing a permanent magnet

Номер: CA2429612A1
Принадлежит: Individual

A stylus (30) that operates utilizing magnetic fields, wherein a permanent magnet (32) is disposed within a passive stylus that is detectable by a plurality of magnetic sensors (10, 12) that remove the magnetic field of the stylus from the earth's relative magnetic field to thereby obtain vectors that are used in a triangulation equation to determine the location of the stylus (30) in two or three dimensions, depending upon the number of magnetic sensors (10, 12) that are used, wherein one set of magnetic sensors can be used as a reference for earth's magnetic field, and wherein each of the magnetic sensors includes a polarizing coil to change direction of sensitivity (14), a null coil (42) and a flipping coil (44).

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22-06-2017 дата публикации

Devices, systems and methods with magnetic structures

Номер: DE102016124651A1
Принадлежит: Analog Devices Global ULC

Eine magnetische Vorrichtung kann eine magnetische Struktur, eine Vorrichtungsstruktur und eine zugehörige Schaltung aufweisen. Die magnetische Struktur kann eine strukturierte Materialschicht mit einer vorbestimmten magnetischen Eigenschaft aufweisen. Die strukturierte Schicht kann dazu konfiguriert sein, z. B. ein Magnetfeld zu schaffen, ein Magnetfeld zu erfassen, einen Magnetfluss zu lenken oder zu konzentrieren, eine Komponente vor einem Magnetfeld abzuschirmen oder eine magnetisch betätigte Bewegung zu schaffen usw. Die Vorrichtungsstruktur kann eine andere Struktur der Vorrichtung sein, die mit der magnetischen Struktur physikalisch verbunden oder relativ zu dieser angeordnet ist, z. B. um die magnetische Struktur strukturell abzustützen, deren Betrieb zu ermöglichen oder anderweitig diese in die magnetische Vorrichtung zu integrieren usw. Die zugehörige Schaltung kann mit der magnetischen Struktur elektrisch verbunden sein, um Signale der magnetischen Struktur zu empfangen, zu liefern, aufzubereiten oder zu verarbeiten. A magnetic device may include a magnetic structure, a device structure, and associated circuitry. The magnetic structure may include a patterned material layer having a predetermined magnetic property. The structured layer may be configured to e.g. For example, to create a magnetic field, detect a magnetic field, direct or concentrate a magnetic flux, shield a component from a magnetic field, or provide magnetically-actuated movement, etc. The device structure may be another structure of the device that has the magnetic structure is physically connected or arranged relative to this, z. For example, to structurally support the magnetic structure, enable it to operate, or otherwise integrate it into the magnetic device, etc. The associated circuitry may be electrically connected to the magnetic structure to receive, deliver, condition, or access signals of the magnetic structure to process.

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01-10-2019 дата публикации

Modules and methods including magnetic sensing structures

Номер: US10429456B2
Принадлежит: Analog Devices Global ULC

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

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30-12-2021 дата публикации

Devices, systems and methods including magnetic structures

Номер: US20210405130A1
Принадлежит: Analog Devices Global ULC

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

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25-06-2020 дата публикации

Combined microscope objective and microwave wire for optically detected magnetic resonance imaging

Номер: WO2020132186A1
Принадлежит: Massachusetts Institute of Technology

A microscope objective is disclosed comprising: a lens; a housing; a lens holder that is arranged to couple the lens to the housing; a first conductor and a second conductor, the first conductor and the second conductor extending along a sidewall of the housing, the first conductor and the second conductor being arranged to form at least one loop that is that is disposed about at least a portion of a perimeter of a field of view of the lens.

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06-04-2004 дата публикации

Method for solid state genome analysis

Номер: US6716578B1
Принадлежит: Bioforce Nanosciences Inc

The invention is a solid state process for analyzing genomes by visualizing sequence specific markers (e.g., proteins that bind a defined DNA sequence elements) by scanning probe microscopy. The method includes linear display of the nucleic acid on a solid surface, image acquisition by the scanning probe microscope, and digital data analysis. The acts of the method result in a bar code type display of each fragment of the DNA sample. These bar codes are then used to place the fragments in the order they appear on the original DNA sample.

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14-02-2006 дата публикации

Method and apparatus for solid state molecular analysis

Номер: US6998228B2
Принадлежит: Bioforce Nanosciences Inc

The invention is a method for the formation and analysis of novel miniature deposition domains. These deposition domains are placed on a surface to form a molecular array. The molecular array is scanned with an AFM to analyze molecular recognition events and the effect of introduced agents on defined molecular interactions. This approach can be carried out in a high throughput format, allowing rapid screening of thousands of molecular species in a solid state array. The procedures described here have the added benefit of allowing the measurement of changes in molecular binding events resulting from changes in the analysis environment or introduction of additional effector molecules to the assay system. The processes described herein are extremely useful in the search for compounds such as new drugs for treatment of undesirable physiological conditions. The method and apparatus of the present invention does not require the labeling of the deposition material or the target sample and may also be used to deposit large size molecules without harming the same.

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22-12-2022 дата публикации

Systems and Methods to Identify Metabolic Subphenotypes and Uses Thereof

Номер: US20220406400A1
Принадлежит: Leland Stanford Junior University

Systems and methods to assess metabolic dysregulation are described. Metabolic dysregulation refers to elevated glycemia or insulin resistance. The systems and methods assess metabolic dysregulation by determining which subphenotypes or underlying pathologies are contributing to the metabolic dysregulation. In some instances, a trained computational model utilizes an individual's glucose time series curve to determine the contribution of various metabolic dysregulation subphenotypes to the individual's metabolic dysregulation. Various applications or treatments can be performed based on the determination of metabolic dysregulation subphenotypes.

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16-05-1995 дата публикации

Implantable limb lengthening nail driven by a shape memory alloy

Номер: US5415660A
Принадлежит: University of Minnesota

An implantable intramedullary bone lengthening device for correction of limb length deficiencies without a need for transcutaneous connections. The implantable intramedullary bone lengthening nail has an implantable housing, an adjustment mechanism attached to the telescoping cylinder housing, and a drive assembly attached to the housing and the adjustment mechanism for transmitting an expansion force to the adjustment mechanism. The implantable housing may be sealed, encapsulating the unit. The intramedullary bone lengthening nail is inserted into the intramedullary cavity of a bone, which may have been enlarged by reaming. The implantable housing of the intramedullary nail is formed from two telescoping cylinders and is affixed at either end to the bone using pins. The adjustment mechanism is attached to both cylinders of the housing and includes a mechanism for expanding the nail and a ratcheting mechanism for regulating the expansion. The drive assembly includes a shape memory alloy to provide an expansion force. The drive mechanism transmits the expansion force in response to an external signal to the adjustment mechanism.

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01-04-2010 дата публикации

Method and apparatus for uniformly adding particulates to a coating on comestibles, and products produced thereby

Номер: US20100077956A1
Принадлежит: Wm Wrigley Jr Co

A process for applying particulates to a large number of comestible cores during the production of comestible cores so as to have a generally uniform application of particulates on each coated core involves the steps of placing a batch of comestible cores in a coating apparatus; applying aliquots of coating syrup while the cores are tumbled in the coating apparatus to build up a coating on the cores; dividing a predetermined total amount of the particulates to be applied to the coated cores into at least three portions of approximately equal size; and applying each of the portions of particulates to the coated cores simultaneously from multiple, spaced apart, particulate distributors in the coating apparatus while the coated cores are being tumbled. Preferably the particulate applicator comprises a number of venturi eductors equal to the number of particulate distributors; a pneumatic hose connected between each venturi eductor and each particulate distributor; and a vibratory pan for holding a quantity of particulates and causing the particulates to vibrate and flow at a uniform rate into each venturi eductor. The process is particularly were suited to uniformly apply speckle particulates to produce coated chewing gum or other confectionery cores with a uniform number of speckles on each core.

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30-05-2007 дата публикации

Method and apparatus for uniformly adding particulates to a coating on comestibles, and products produced thereby

Номер: EP1788888A1
Принадлежит: Wm Wrigley Jr Co

A process for applying particulates to a large number of comestible cores during the production of comestible cores so as to have a generally uniform application of particulates on each coated core involves the steps of placing a batch of comestible cores in a coating apparatus; applying aliquots of coating syrup while the cores are tumbled in the coating apparatus to build up a coating on the cores; dividing a predetermined total amount of the particulates to be applied to the coated cores into at least three portions of approximately equal size; and applying each of the portions of particulates to the coated cores simultaneously from multiple, spaced apart, particulate distributors in the coating apparatus while the coated cores are being tumbled. Preferably the particulate applicator comprises a number of venturi eductors equal to the number of particulate distributors; a pneumatic hose connected between each venturi eductor and each particulate distributor; and a vibratory pan for holding a quantity of particulates and causing the particulates to vibrate and flow at a uniform rate into each venturi eductor. The process is particularly were suited to uniformly apply speckle particulates to produce coated chewing gum or other confectionery cores with a uniform number of speckles on each core.

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30-12-2003 дата публикации

Reduced side-effect hemoglobin compositions

Номер: US6670323B1

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

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01-05-2007 дата публикации

Reduced side-effect hemoglobin compositions

Номер: US7211560B2

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

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06-12-2011 дата публикации

Water resistant cementitious article and method for preparing same

Номер: US8070895B2
Принадлежит: United States Gypsum Co

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

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29-01-2009 дата публикации

Mat-faced gypsum board and method of making thereof

Номер: US20090029141A1
Принадлежит: United States Gypsum Co

A mat-faced gypsum board and method of making thereof is provided having a particulate matter applied on an inner surface of the facer mat and extending partially into the mat from the inner surface thereof. The particulate matter, which is preferably a hydratable powder such as calcium sulfate hemihydrate, minimizes and, preferably, prevents bleed through of a gypsum slurry during formation of the gypsum board.

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11-12-2012 дата публикации

Cementitious article and method for preparing the same

Номер: US8329308B2
Принадлежит: United States Gypsum Co

A cementitious article and a method of making a cementitious article are disclosed. The cementitious article comprises a cementitious component that comprises a polyvinyl acetate type polymer, a monobasic phosphate, and optionally boric acid. Cementitious articles, such as board, are prepared such that the polyvinyl acetate type polymer, the monobasic phosphate, and optionally boric acid can be present in the cementitious core, and/or in dense layers if present. The concentration of the polyvinyl acetate type polymer, monobasic phosphate, and optionally boric acid in the cementitious article can increase from a central region A to peripheral regions B and C, respectively. In some embodiments, the polyvinyl acetate type polymer is a polyvinyl alcohol and the monobasic phosphate is monoammonium phosphate.

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29-10-2013 дата публикации

Water resistant cementitious article and method for preparing same

Номер: US8568544B2
Принадлежит: United States Gypsum Co

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

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08-08-1995 дата публикации

Reprogrammable subscriber terminal

Номер: US5440632A
Принадлежит: Scientific Atlanta LLC

A reprogrammable subscriber terminal of a subscription television service which can have the control program code of its control processor modified by downloading new program code from the headend. The control processor stores a boot program in an internal read only memory. Upon start up and resets, the boot program determines whether the control program should be changed from a command sent from the headend. The command, termed a parameters transactions, includes the number of expected download program code transactions required to complete the control code modification, the memory space areas where the code is to be loaded, and the channel over which the download program code transactions are to be transmitted. The channel is tuned and when the boot program receives all the download program code transactions accurately and stores them, the boot program will cause the control program to be restarted at a selected address of the new or modified control program code which has been downloaded. The boot program may download code to different configurations of subscriber terminals including those with Flash EPROM or extended memories from plug-in expansion modules.

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22-03-1994 дата публикации

Method of enantioselectively inserting a carbene

Номер: US5296595A
Автор: Michael P. Doyle
Принадлежит: Research Corp Technologies Inc

A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes a two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation.

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01-10-2019 дата публикации

Low profile valve locking mechanism and commissure assembly

Номер: US10426617B2
Принадлежит: Boston Scientific Scimed Inc

A replacement heart valve locking mechanism may include a buckle member fixedly attached to a tubular anchor member defining a central longitudinal axis, a post member axially translatable relative to the buckle member, and an actuator member releasably connected to the post member at an attachment point. The post member may include a latch portion configured to engage a catch formed in the buckle member such that movement of the post member distally relative to the buckle member is prevented. The attachment point may be disposed proximal of the latch portion. Circumferential translation of the latch portion about the central longitudinal axis may disengage the latch portion from the catch.

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10-03-2020 дата публикации

Medical device handle

Номер: US10583005B2
Принадлежит: Boston Scientific Scimed Inc

A medical device handle may include a handle housing including a cavity disposed within the handle housing. The medical device handle may include a carriage assembly disposed within the cavity and operatively connected to the tubular member and the medical implant, the carriage assembly being longitudinally movable between a distal position and a proximal position by rotation of a control knob with respect to the handle housing, the control knob being disposed around a proximal end of the handle housing. The carriage assembly may include a carriage member, a first sliding member, a second sliding member, and a locking element configured to releasably fix the first sliding member and the second sliding member relative to the carriage member. The locking element may be rotatable relative to the handle housing.

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12-02-2019 дата публикации

Replacement heart valve implant with invertible leaflets

Номер: US10201416B2
Принадлежит: Boston Scientific Scimed Inc

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

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13-12-2018 дата публикации

Heart valve implant commissure support structure

Номер: WO2018226915A1
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

A replacement heart valve implant defining a central longitudinal axis extending from an upstream end to a downstream end may include an expandable anchor member configured to shift between a delivery configuration and a deployed configuration, a circumferential support member distinct from and attached to the expandable anchor member, at least a portion of the circumferential support member extending downstream of the expandable anchor member, and a plurality of valve leaflets secured to the expandable anchor member. The plurality of valve leaflets may include a valve leaflet commissure movable from a first longitudinal position relative to the downstream end in the delivery configuration to a second longitudinal position relative to the downstream end in the deployed configuration.

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07-02-2019 дата публикации

Medical implant locking mechanism

Номер: WO2019028161A1
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

A medical device system may include a replacement heart valve implant including an expandable anchor member reversibly actuatable between a delivery configuration and a deployed configuration, wherein the replacement heart valve implant includes at least one locking mechanism configured to lock the expandable anchor member in the deployed configuration, and at least one actuator element configured to releasably engage the at least one locking mechanism and actuate the expandable anchor member between the delivery configuration and the deployed configuration. The at least one actuator element may include external threads on a distal portion of each actuator element and a ramp disposed proximal of the external threads.

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09-03-2021 дата публикации

Replacement heart valve commissure assembly

Номер: US10939996B2
Принадлежит: Boston Scientific Scimed Inc

A replacement heart valve commissure assembly may include a locking mechanism including a first locking portion spaced apart from a second locking portion in a delivery configuration and configured to engage with the second locking portion in a deployed configuration, wherein the first locking portion is longitudinally actuatable relative to the second locking portion between the delivery and deployed configurations. The commissure assembly may include a first valve leaflet and a second valve leaflet each secured to the first locking portion. A first sleeve portion of the first valve leaflet may be fixedly attached to a first fabric sleeve wrapped around a first leg of the first locking portion by a first filament, and a second sleeve portion of the second valve leaflet may be fixedly attached to a second fabric sleeve wrapped around a second leg of the first locking portion by a second filament.

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28-10-2014 дата публикации

System and method for cardiac valve repair and replacement

Номер: US8870948B1
Принадлежит: Cephea Valve Technologies Inc

A prosthetic mitral valve includes a proximal anchor, a distal anchor, and a central portion therebetween. The proximal and distal anchors each include a first outer frame and a second outer frame. The first outer frame includes a plurality of first arcs joined together, and the second outer frame includes a plurality of second arcs joined together. The plurality of first arcs are out of phase relative to the plurality of second arcs.

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22-09-2020 дата публикации

Medical device handle

Номер: US10779940B2
Принадлежит: Boston Scientific Scimed Inc

A medical device handle for percutaneous delivery of a medical device implant may include an elongated handle housing having a proximal end, a distal end, and a longitudinal axis extending from the proximal end to the distal end; a rotatable collar disposed about the proximal end of the handle housing; and a rotatable control knob disposed about a proximal portion of the rotatable collar. The rotatable collar may include a first internally-facing longitudinal slot extending less than a full length of the rotatable collar and terminating proximally at a distally-facing wall of an internally-facing circumferentially-oriented slot. The rotatable control knob may be configured to actuate the medical device implant between a delivery configuration, a deployed configuration, and a released configuration.

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02-04-2019 дата публикации

Containment vessel with implant sheathing guide

Номер: US10245136B2
Принадлежит: Boston Scientific Scimed Inc

A containment vessel for storing and rinsing a medical implant coupled to a delivery system having an outer sheath may include a hollow element having a wall, a proximal end, a distal end, and a lumen extending between the proximal end and the distal end, the lumen of the hollow element being configured and adapted to contain a medical implant in a partially-deployed configuration during storage and rinsing of the medical implant and a proximal end cap including a secondary proximal end cap removably secured to the proximal end cap and configured to reversibly seal the proximal end cap to the outer sheath, thereby establishing a closed fluid connection between the lumen of the hollow element and a lumen of the outer sheath. The proximal end cap may include a sheathing guide configured and adapted to direct the medical implant into the lumen of the outer sheath.

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18-12-2018 дата публикации

System and method for cardiac valve repair and replacement

Номер: US10154906B2
Принадлежит: Cephea Valve Technologies Inc

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

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07-02-2017 дата публикации

System and method for cardiac valve repair and replacement

Номер: US9561103B2
Принадлежит: Cephea Valve Technologies Inc

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

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21-04-2020 дата публикации

System and method for cardiac valve repair and replacement

Номер: US10624742B2
Принадлежит: Cephea Valve Technologies Inc

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

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11-12-2018 дата публикации

System and method for cardiac valve repair and replacement

Номер: US10149761B2
Принадлежит: Cephea Valve Technologies Inc

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

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31-01-2017 дата публикации

System and method for cardiac valve repair and replacement

Номер: US9554899B2
Принадлежит: Cephea Valve Technologies Inc

A prosthetic mitral valve comprising an expandable anchor comprising a first anchor, a central portion and a second anchor; wherein the first anchor comprises a first outer frame and a second outer frame, the first outer frame comprising a plurality of first arcs joined together, and the second outer frame comprising a plurality of second arcs joined together, wherein the plurality of first arcs are out of phase relative to the plurality of second arcs when the first anchor is viewed in an end view from the first anchor to the second anchor; and a plurality of replacement leaflets secured to the expandable anchor.

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22-12-2020 дата публикации

Replacement cardiac valves and methods of use and manufacture

Номер: US10869755B2
Принадлежит: Cephea Valve Technologies Inc

Prosthetic mitral valves and their methods of manufacture and use.

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12-07-2022 дата публикации

Medical device handle

Номер: US11382742B2
Принадлежит: Boston Scientific Scimed Inc

A medical device handle may include a handle housing including a cavity disposed within the handle housing. The medical device handle may include a carriage assembly disposed within the cavity and operatively connected to the tubular member and the medical implant, the carriage assembly being longitudinally movable between a distal position and a proximal position by rotation of a control knob with respect to the handle housing, the control knob being disposed around a proximal end of the handle housing. The carriage assembly may include a carriage member, a first sliding member, a second sliding member, and a locking element configured to releasably fix the first sliding member and the second sliding member relative to the carriage member. The locking element may be rotatable relative to the handle housing.

Подробнее
14-07-2020 дата публикации

Replacement heart valve implant with invertible leaflets

Номер: US10709552B2
Принадлежит: Boston Scientific Scimed Inc

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

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14-05-1991 дата публикации

Electronic filters, hearing aids and methods

Номер: US5016280A
Принадлежит: Central Institute For The Deaf

An electronic filter for an electroacoustic system. The system has a microphone for generating an electrical output from external sounds and an electrically driven transducer for emitting sound. Some of the sound emitted by the transducer returns to the microphone means to add a feedback contribution to its electical output. The electronic filter includes a first circuit for electronic processing of the electrical output of the microphone to produce a filtered signal. An adaptive filter, interconnected with the first circuit, performs electronic processing of the filtered signal to produce an adaptive output to the first circuit to substantially offset the feedback contribution in the electrical output of the microphone, and the adaptive filter includes means for adapting only in response to polarities of signals supplied to and from the first circuit. Other electronic filters for hearing aids, public address systems and other electroacoustic systems, as well as such systems, and methods of operating them are also disclosed.

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03-09-2002 дата публикации

Caffeine coated chewing gum product and process of making

Номер: US6444241B1
Принадлежит: Wm Wrigley Jr Co

A method for producing a chewing gum with a controlled release of caffeine, as well as the chewing gum so produced, is obtained by physically modifying caffeine's properties by coating and drying. Caffeine is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated caffeine is then preferably co-dried and particle sized to produce a release-modified caffeine for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. Also disclosed is a chewing gum pellet having a coating including caffeine or a caffeine salt compound.

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04-11-1986 дата публикации

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

Номер: US4620865A
Принадлежит: Eli Lilly and Co

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.

Подробнее
05-06-2001 дата публикации

Preparation of biopolymer arrays

Номер: US6242266B1
Принадлежит: AGILENT TECHNOLOGIES INC

A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.

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22-06-2000 дата публикации

Chewing gum containing medicament active agents

Номер: WO2000035298A1
Принадлежит: WM. WRIGLEY JR. COMPANY

A method for producing a chewing gum with a controlled release active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the active agent by coating and drying. The active agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated active agent is preferably then co-dried and particle sized to produce a release-modified active agent for use in chewing gum. The active agent may also be used in a coating on a chewing gum product, as part of a rolling compound applied to the chewing gum product, or as a part of the liquid in a liquid-center chewing gum product.

Подробнее
03-09-2002 дата публикации

Quantum dot thermoelectric materials and devices

Номер: US6444896B1
Принадлежит: Massachusetts Institute of Technology

Quantum-dot superlattice (QLSL) structures having improved thermoelectric properties are described. In one embodiment, PbSe x Te 1−x /PbTe QDSLs are provided having enhanced values of Seebeck coefficient and thermoelectric figure of merit (ZT) relative to bulk values.

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12-08-2003 дата публикации

Nanostructured thermoelectric materials and devices

Номер: US6605772B2
Принадлежит: Massachusetts Institute of Technology

Quantum-dot superlattice (QLSL) structures having improved thermoelectric properties are described. In one embodiment, PbSe x Te 1-x /PbTe QDSLs are provided having enhanced values of Seebeck coefficient and thermoelectric figure of merit (ZT) relative to bulk values. The structures can be combined into multi-chip devices to provide additional thermoelectric performance.

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01-11-2005 дата публикации

Laminated sheets for use in a fully retrievable occlusion device

Номер: US6960224B2
Принадлежит: Cardia Inc

An occlusion device having laminated polyvinyl alcohol sheets for occluding a defect. The laminated polyvinyl alcohol sheets provide an increased tear strength to the sheets that allows the device to be fully retrievable through the same catheter used to deploy it. The laminated sheets are created by obtaining thin sheets of polyvinyl alcohol foam, arranging the sheets on one another, and applying heat and pressure to laminate the sheets together.

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30-09-2003 дата публикации

Method of producing active agent coated chewing gum products

Номер: US6627234B1
Принадлежит: Wm Wrigley Jr Co

A method for producing a chewing gum with an improved release of active agent, as well as the chewing gum so produced, is obtained by adding an active agent to a chewing gum coating. The active agent is added to the coating in a coating solution or premixed with a flavor or solvent. The coating solution may contain sweetener or other transdermal enhancing agents to obtain increased transmucosal absorption. An active agent may also be used in the gum core.

Подробнее
06-01-1998 дата публикации

Adaptive gain and filtering circuit for a sound reproduction system

Номер: US5706352A
Принадлежит: K/S Himpp

Adaptive compressive gain and level dependent spectral shaping circuitry for a hearing aid include a microphone to produce an input signal and a plurality of channels connected to a common circuit output. Each channel has a preset frequency response. Each channel includes a filter with a preset frequency response to receive the input signal and to produce a filtered signal, a channel amplifier to amplify the filtered signal to produce a channel output signal, a threshold register to establish a channel threshold level, and a gain circuit. The gain circuit increases the gain of the channel amplifier when the channel output signal falls below the channel threshold level and decreases the gain of the channel amplifier when the channel output signal rises above the channel threshold level. A transducer produces sound in response to the signal passed by the common circuit output.

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16-12-2009 дата публикации

Adaptive gain and filtering circuit for a sound reproduction system

Номер: EP1175125B1
Принадлежит: K S HIMPP, K/S Himpp

Подробнее
05-11-2019 дата публикации

Personalized event detection methods and related devices and systems

Номер: US10463297B2
Принадлежит: Medtronic Minimed Inc

Medical devices and related patient management systems and event detection methods are provided. An exemplary method of detecting events pertaining to operation of a medical device, such as an infusion device, involves obtaining measurements indicative of a condition in a body of a patient, determining statistics for an analysis interval based on the measurements, and determining an event probability associated with the analysis interval based on historical event data associated with the patient. An event detection model associated with the patient is obtained and applied to the statistics and the event probability to identify occurrence of the event using the event detection model, and in response, an indication of the event associated with the analysis interval is provided, for example, by tagging or marking data in a database, displaying graphical indicia of the event, or the like.

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15-12-2020 дата публикации

Data analytics and insight delivery for the management and control of diabetes

Номер: US10867012B2
Принадлежит: Medtronic Minimed Inc

A computer-implemented system and related method of managing use of a diabetes management device are presented here. An embodiment of the method obtains input data for a user of the diabetes management device, and compares the input data against historical event/outcome combinations maintained for the user. Each of the event/outcome combinations includes insight event data indicative of a glycemic event and a glycemic outcome corresponding to the insight event data. The method determines, based on the comparing, a correlation between the input data and a glycemic outcome. The method continues by generating a glycemic insight message for delivery to the user, wherein the glycemic insight message includes information regarding a relationship between at least some of the input data and the glycemic outcome.

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22-01-2002 дата публикации

Matrices with memories

Номер: US6340588B1
Принадлежит: Discovery Partners International Inc

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, sensors and drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided. Sensors containing a memory in combination with a matrix are also provided.

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18-12-2007 дата публикации

Electric gear motor drive for switching valve

Номер: US7308904B2
Принадлежит: Megtec Systems Inc

Electric drive for a switching valve, the switching valve having such a drive, and a regenerative thermal oxidizer including the switching valve and drive system. The electric drive system allows for the starting and stopping of the rotation of a rotary valve with accurate positioning. The stopping of the valve includes dissipation of the kinetic energy of the valve by electric means. The valve is allowed to move vertically and oscillating rotary motion is possible. The drive system preferably includes a gear, gearbox, variable speed drive and at least one positioning sensor. Valve acceleration and deceleration can be carried out in a controlled fashion and with repeatability, so that the final end position of the valve is consistent. The accommodation of vertical movement of the valve is also within the scope of the present invention.

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22-06-2000 дата публикации

Improved release of medicament active agents from a chewing gum coating

Номер: WO2000035296A1
Принадлежит: WM. WRIGLEY JR. COMPANY

A method for producing a chewing gum with an improved release of active agent, as well as the chewing gum so produced, is obtained by adding an active agent to a chewing gum coating. The active agent is added to the coating in a coating solution or premixed with a flavor or solvent. The coating solution may contain sweetener or other transdermal enhancing agents to obtain increased transmucosal absorption. An active agent may also be used in the gum core.

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10-02-2004 дата публикации

Method and apparatus for liquid transfer

Номер: US6689323B2
Принадлежит: AGILENT TECHNOLOGIES INC

Liquids are transferred from a plurality of wells or depots having openings arranged in a selected format to one or more receptacles, by displacing liquid contained in each well so that a convex meniscus swells from the opening, and contacting the receptacle with the swollen meniscus to draw a portion of the liquid into the receptacle. According to the invention, the liquid transfer is effected directly from the depot to the corresponding receptacle without contact between depots and receptacles, and without interposition of any transfer device between depots and receptacles. Apparatus for carrying out the method includes a depot member having a plurality of wells having openings supported in a selected format, and a receiving member defining at least one receptacle and usually a plurality of receptacles in a corresponding or complementary format; a device for displacing liquid contained within the wells toward and through the openings; and a device for bringing at least one selected well opening into proximity with at least one selected receptacle. In some embodiments the liquid is displaced by inwardly deforming portions of the walls of the wells; in other embodiments the liquid is displaced by introducing a displacing fluid into the wells at a point away from the openings. The inventions is particularly useful in transferring a multiplicities of liquids from preparative or storage depots to receptacles formed in planar members such as planar microfluidics devices or printing devices adapted for deposition of materials in microarrays.

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11-12-2001 дата публикации

Automated sorting system for matrices with memory

Номер: US6329139B1
Принадлежит: Discovery Partners International Inc

Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.

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01-11-2005 дата публикации

Hoop design for occlusion device

Номер: US6960220B2
Принадлежит: Cardia Inc

The present invention is an occlusion device having a support hoop. The support hoop increases the ability of the occlusion device to form a seal around the defect and adds additional structural strength to the device by allowing distribution of pressure along a 360° continuum.

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19-08-2008 дата публикации

Flexible medical device

Номер: US7413563B2
Принадлежит: Cardia Inc

This invention relates to flexible medical device. The flexible medical device may comprise interlocking portions formed of a continuous channel. When formed of a continuous channel, the medical device comprises interconnected interlocking portions, rather than independent interlocking portions. The flexible medical device may also be designed so that different portions of the device have different flexibility characteristics.

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26-07-2005 дата публикации

Flexible delivery device

Номер: US6921397B2
Принадлежит: Cardia Inc

This invention relates to catheter delivery systems, and more specifically, to a tubular device with improved torque and flexure characteristics. The present invention is a tubular device having improved torque and flexure characteristics which uses a series of permanently interlocking independent segments to provide the necessary torque and flexure characteristics.

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24-04-2001 дата публикации

Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids

Номер: US6221653B1
Принадлежит: AGILENT TECHNOLOGIES INC

Methods are provided for depositing a quantity of fluid onto the surface of an array. In the subject methods, a thermal inkjet head loaded with the fluid is positioned in opposing relationship to, e.g. over, the array surface. Actuation of the thermal inkjet results in the expulsion of a quantity of fluid onto the array surface. The subject methods find particular use in array-based binding assays in which an array of binding agents is employed for the detection of an analyte(s), particularly array-based hybridization assays.

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02-10-2007 дата публикации

Methods of fabricating an addressable array of biopolymer probes

Номер: US7276336B1
Принадлежит: AGILENT TECHNOLOGIES INC

A method of fabricating an addressable array of biopolymer probes on a substrate according to a target array pattern using a deposition apparatus, and a deposition apparatus which can execute the method and computer program products for the apparatus. The deposition apparatus which, when operated according to a target drive pattern based on nominal operating parameters of the apparatus, provides the probes on the substrate in the target array pattern. The method includes examining at least one operating parameter for an error from a nominal value which error will result in use of the target drive pattern producing a discrepancy between the target array pattern and an actual array pattern deposited. When an error is detected deriving, based on the error, a corrected drive pattern different from the target drive pattern such that use of the corrected drive pattern results in a reduced discrepancy between the target and actual array patterns.

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16-10-2003 дата публикации

New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors

Номер: WO2003084539A2

The present invention relates to novel pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.

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03-11-2005 дата публикации

Pharmaceutical combinations containing benzoxazine for treating respiratory diseases

Номер: WO2005102349A1

The invention relates to novel pharmaceutical combinations containing at least one active ingredient (2) in addition to at least one, preferably one, compound of general formula (1) wherein the radicals R1, R2 and R3 have the designations cited in the patent claims and in the description. The invention also relates to a method for producing said combinations and to the use thereof as medicaments.

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01-02-2006 дата публикации

Composition comprising a steroid and an anticholinergic agent

Номер: EP1621197A2

New medicaments contain a quaternized 2,2-diphenylpropionic acid scopine ester anticholinergic agent (I) and a beta -mimetic agent (II). New medicaments contain: (a) a scopine derivative anticholinergic agent of formula (I); (b) at least one beta -mimetic agent (II) (optionally in the form of enantiomers, enantiomer mixtures, racemates, solvates or hydrates); and optionally (c) pharmaceutical auxiliaries. [Image] X ->monovalent anion, preferably chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulfonate. ACTIVITY : Antiinflammatory; Antiasthmatic. MECHANISM OF ACTION : Anticholinergic; Synergist.

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04-10-2006 дата публикации

Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases

Номер: EP1707205A2

The present invention relates to novel pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.

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19-04-2007 дата публикации

Novel pharmaceutical combinations for the treatment of respiratory disorders

Номер: WO2007042467A1

The present invention relates to novel pharmaceutical combinations which, besides one or more, preferably one, compound of the general formula (1) in which the radicals R1, R2 and R3 have the meanings stated in the claims and in the description, comprise at least one further active ingredient 2, method for the manufacture thereof, and the use thereof as pharmaceutical.

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04-07-2007 дата публикации

Medicaments for inhalation comprising betamimetics and an anticholinergic

Номер: EP1803469A2

The present invention relates to novel pharmaceutical compositions based on beta 2 agonists and salts of an anticholinergic, processes for preparing them and their use in the treatment of respiratory complaints.

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29-02-2012 дата публикации

New medicine combinations for treating respiratory diseases

Номер: EP2422786A1

A composition comprises at least one 6-hydroxy-4H-benzo[1,4]oxazin-3-one derivative and at least one other active substance. A composition comprises at least one 6-hydroxy-4H-benzo[1,4]oxazin-3-one compounds of formula (I) and at least one other active substance. n : 1 or 2; R 1 and R 2 : H, halo, 1-4C alkyl or -O-1-4C alkyl;and R 3 : 1-4C alkyl, OH, halo, -O-1-4C alkyl, -O-1-4C alkylene-COOH or -O-1-4C alkylene-CO-O-1-4C alkyl. [Image] ACTIVITY : Antiinflammatory; Respiratory-Gen.; Antiasthmatic; Dermatological; Immunosuppressive; Antiallergic; Cardiant; Vasotropic. MECHANISM OF ACTION : None given.

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01-06-2006 дата публикации

Inhalation medicament containing a novel anticholinesterase drug, formoterol and a steroid

Номер: WO2006056526A1
Автор: Michael P. Pieper

The invention relates to novel medicament compositions based on a novel anticholinesterase drug, formoterol salts and on a corticosteroid, to a method for the production thereof and to their use for treating respiratory disorders.

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05-10-1999 дата публикации

Matrices with memories and uses thereof

Номер: US5961923A
Принадлежит: Irori Inc

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

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