Water resistant cementitious article and method for preparing same

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

Pharmaceutical compositions based on anticholinergics and corticosteroids

A pharmaceutical composition comprising an anticholinergic and a steroid, optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the steroid optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of respiratory tract diseases.

Automatically generating a business process flow gui using a symbolic annotation language

A method, system, and computer program product for displaying an automatically generated graphical display of a business process flow to facilitate user interaction with enterprise software applications. A compact symbolic annotation language is used in conjunction with a flow generator to automatically generate a computer renderable description of the business process flow. The method commences by defining symbols to form an alphabet to be used in the symbolic annotation language. The compact symbolic language is capable of representing rich semantics including process operations, fork operations, and join operations. Once an agent (e.g., a person, a computer agent) has captured a particular business process flow using symbols of the compact symbolic annotation language, then a computer process performs a mapping of the symbols to a markup language. The markup language can be rendered in a graphical display. The markup language can be HTML/CSS, SVG, UML, or another markup language.

Combinations of medicaments for the treatment of respiratory diseases

A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R 1 is hydrogen, halogen, C 1-4 -alkyl, or O—C 1-4 -alkyl; R 2 is hydrogen, halogen, C 1-4 -alkyl, or O—C 1-4 -alkyl; and R 3 is hydrogen, C 1-4 -alkyl, OH, halogen, O—C 1-4 -alkyl, O—C 1-4 -alkylene-COOH, or O—C 1-4 -alkylene-COO—C 1-4 -alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

Enhanced partially-aminated metal-organic frameworks

Described is an enhanced partially-aminated metal-organic framework comprising, or prepared from, metal cations and a synergistically effective ratio of a multi-carboxylic acid and an amino-substituted derivative of the multi-carboxylic acid, or the acceptable salts thereof, or any combination thereof; a manufactured article comprising the enhanced partially-aminated metal-organic framework; a method of preparing the enhanced partially-aminated metal-organic framework, and a method of using the enhanced partially-aminated metal-organic framework for separating carbon dioxide gas or other acid gas from an ad rem gas mixture.

Fixation for implantable medical devices

A tine portion of an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from a distal end of the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, for example, defined by a single radius, preferably tapers from a first width thereof, in proximity to a proximal end thereof, to a smaller, second width thereof, in proximity to the distal end thereof, wherein the tip has a width that is greater than the second width of the hook segment. Alternately, the tine portion may include a hook segment that is defined by two radii and a straight section extending therebetween.

Medical product and method for eliminating symptoms of nicotine withdrawal

In essence, the present invention relates to a medical product including between about 94% and about 98% of a saline solution, preferably a normal saline solution containing about 0.9% sodium chloride dissolved in water, about ⅛ th of 1 milligram of relatively pure nicotine and about 3 milligrams of relatively pure nicotine. The medical product also includes about 1% and 3% of one or more flavors selected from the group consisting of citrus, tobacco, apple, cherry, maple, menthol, hazelnut, peach, lemon, vanilla and chocolate and 1% citric acid for taste. In addition, the medical product includes about 1% to 2% of ethyl alcohol for cleaning a micron mesh grid that generates particles of pure nicotine of from 2 to 5 microns that are drawn through an entrainment port, through a capsule containing the medical product through the micron mesh grid and into the individual's lungs and into their bloodstream.

Biaryl compositions and methods for modulating a kinase cascade

The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy

The present disclosure relates to inhibitors of mitochondrial function. Methods of treating hypoxic cancer cells using anti-angiogenic agents and mitochondrial biogenesis inhibitors are disclosed. Tetracyclines, such as doxycycline, may serve as mitochondrial biogenesis inhibitors. Also described are methods of sensitizing hypoxic cancer cells to one or more chemotherapies by administering a mitochondrial biogenesis inhibitor with the chemotherapy.

Replacement heart valve commissure assembly

A replacement heart valve commissure assembly may include a locking mechanism including a first locking portion spaced apart from a second locking portion in a delivery configuration and configured to engage with the second locking portion in a deployed configuration, wherein the first locking portion is longitudinally actuatable relative to the second locking portion between the delivery and deployed configurations. The commissure assembly may include a first valve leaflet and a second valve leaflet each secured to the first locking portion. A first sleeve portion of the first valve leaflet may be fixedly attached to a first fabric sleeve wrapped around a first leg of the first locking portion by a first filament, and a second sleeve portion of the second valve leaflet may be fixedly attached to a second fabric sleeve wrapped around a second leg of the first locking portion by a second filament.

User-Configured Restrictions for Accessing Online Accounts Via Different Access Methods

According to one embodiment, a system includes a memory comprising instructions, an interface, and a processor communicatively coupled to the memory and the interface. The interface is configured to receive one or more account access rules, the account access rules comprising restrictions on accessing an online account through one or more access methods, and receive, via a first access method, a request to access the online account. The processor is configured, when executing the instructions, to determine, based on the account access rules, whether the online account may be accessed using the first access method.

Caveolin-1 related methods for treating glioblastoma with temozolomide

This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temoxolomide to be glioblastoma multiforme-afflicted subject, wherein the subject's glioblastoma multiforme cells are known to be caveolin-1-positive. This invention also provides a method for determining whether a subject afflicted with glioblastoma multiforme is likely to progress therapeutically in response to a therapeutically effective regimen of temoxolomide comprising determining whether the subject's glioblastoma multiforme cells are caveolin-1-positive, whereby if the subject's glioblastoma multiforme cells are caveolin-1-positive, the subject is likely to progress therapeutically in response to a therapeutically effective regimen of temozolomide.

Systems and Temporal Alignment Methods for Evaluation of Gestational Age and Time to Delivery

Methods to compute gestational age and time to delivery utilizing temporal alignment methods and applications thereof are described. Generally, systems utilize analyte measurements collected at one or more time points to determine a gestational age and time to delivery, which can be used as a basis to perform interventions and treat individuals. Computational models trained utilizing temporal alignment of analyte measurements can be used to determine gestational age and time to delivery.

Materials that Resist Fouling and Methods for Identifying Same

In general, the present invention is directed to materials that when in use resist fouling on their surfaces. Such materials may be used in the construction of various process equipment having surfaces exposed to a given fluid that contains a foulant or chemical substance that may deposit on, or adhere to, the surface and thereafter continue to grow on the surface resulting in deteriorated performance of the equipment and process. The materials are specifically selected using a method that takes into account the dielectric spectra of the fluid to which the surface is exposed and the surface itself. It has been unexpectedly found that if the dielectric spectra of the surface and the fluid are matched to within relative agreement, there should be no adhesion of the foulant on the surface. In some embodiments, the dielectric spectra to be matched include the intrinsic indexes of refraction.

Composite based leading edge kit for a pool and/or spa cover system

Provided is a pool and/or spa cover leading edge kit for use with a pool and/or spa cover system. The kit includes at least two annular shaped fiber reinforced polymer composite segments capable of being axially aligned and interconnected at their abutting ends with each annular shaped fiber reinforced polymer composite segment having an axial length of from 3 feet to 20 feet. The kit also includes at least one joiner capable of interconnecting together a pair of abutting axially aligned annular shaped fiber reinforced polymer composite segments at their axial ends to form a segmented leading edge with an overall axial length of from 6 feet to 50 feet that is capable of being coupled to a pool and/or spa cover. The at least two annular shaped fiber reinforced polymer composite segments of the segmented leading edge include at least one of continuous fibers or discontinuous fibers oriented at least partially in the axial direction and encapsulated by a thermoset or thermoplastic resin matrix. After installation on the pool or spa, the segmented leading edge provides a deflection across the width of the pool or spa of from 0 to less than or equal to 0.10 inches per 10 feet of width of the pool or spa, and has a linear weight per foot of from 4 to 14 ounces per foot of axial length.

Biaryl compositions and methods for modulating a kinase cascade

The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm

The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.

Gait data collection and analytics system and methods for operating unweighting training systems

Described herein are fields of exercise or therapy systems in particular exercise or therapy systems that controllably generate and maintain an unweighted environment using a mechanical system or a differential air pressure (DAP) envelope about a user so as to at least partially or completely unweight the user. This application also relates to improved control systems for pressure chambers for use in differential air pressure (DAP) systems including data collection and utilization for general fitness use, athletic use, or medical use treadmills and related software, control and analytics systems, especially as related to obtaining gait data from load cells provided in the system.

System and method for cardiac valve repair and replacement

A prosthetic mitral valve comprising an expandable anchor comprising a first anchor, a central portion and a second anchor; wherein the first anchor comprises a first outer frame and a second outer frame, the first outer frame comprising a plurality of first arcs joined together, and the second outer frame comprising a plurality of second arcs joined together, wherein the plurality of first arcs are out of phase relative to the plurality of second arcs when the first anchor is viewed in an end view from the first anchor to the second anchor; and a plurality of replacement leaflets secured to the expandable anchor.

Industrial vehicle armrest

An armrest includes an upper support section having one or more ventilation and drainage apertures that couple an upper surface of the upper support section to a lower portion of the armrest to facilitate airflow and drainage between the upper surface of the upper support section and the lower portion of the armrest. The armrest also includes one or more control implements and an arm pad removably coupled to the upper support section. The arm pad includes one or more pad apertures formed therein that communicate with the ventilation and drainage apertures to allow ventilation and drainage between an upper surface of the arm pad and the lower portion of the armrest.

System and method for cardiac valve repair and replacement

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

Msf reprograms myofibroblasts toward lactate production and fuel anaerboic tumor growth

Presented herein is a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an agent that inhibits the MSF/Cdc42/NFkB cascade in the subject's tumor-associated fibroblasts.

Azithromycin and roxithromycin derivtives as senolytic drugs

This disclosure describes the use of azithromycin, roxithromycin, and telithromycin, including derivatives thereof, as senolytic drugs. BrdU was used to induce senescence in model human fibroblast cell lines. Also disclosed are methods for screening compounds for senolytic activity. The SRB assay was used to measure cell viability through protein content. Azithromycin roxithromycin, and telithromycin, clinically-approved pharmaceuticals, were found to be senolytic drugs. However, the closely-related parent compound, erythromycin, showed no senolytic activity. Azithromycin strongly induced both aerobic glycolysis and autophagy in human fibroblasts, but showed bi-phasic effects including on mitochondrial oxygen consumption rates with inhibitory activity at 50 μM and stimulatory activity at 100 μM. The xCELLigence real-time assay system showed that azithromycin preferentially targets senescent cells, removing approximately 97% (nearly a 25-fold reduction in senescent cells).

Companion diagnostics for mitochondrial inhibitors

The present disclosure relates to methods of identifying patients that may be responsive to mitochondrial inhibitor therapies to target and eradicate cancer stem cells. Also described are diagnostic kits that may be used to identify patients responsive to mitochondrial inhibitor therapies.

Biaryl piperidine amide compounds and methods of use thereof

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

Replacement heart valve implant with invertible leaflets

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

Method and apparatus for limiting access to data by process or computer function with stateless encryption

Systems and methods related to DRM content usage mechanisms for both online and offline usage of content are disclosed, including systems providing secure access to data regardless of network state or connectivity state to the networked access control mechanism. An access control mechanism having a secondary offline access control mechanism is presented, further including multiple implementations for data encapsulation, as well as providing a method for writes to files and to the filesystem itself by externally created applications with no API or modification to their operation.

Method and apparatus for limiting access to data by process or computer function with stateless encryption

Systems and methods related to DRM content usage mechanisms for both online and offline usage of content are disclosed, including systems providing secure access to data regardless of network state or connectivity state to the networked access control mechanism. An access control mechanism having a secondary offline access control mechanism is presented, further including multiple implementations for data encapsulation, as well as providing a method for writes to files and to the filesystem itself by externally created applications with no API or modification to their operation.

Triphenylphosphonium-derivative compounds for eradicating cancer stem cells

Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signaling in living cells. TPP-related compounds may be utilized to target mitochondria in cancer stem cells (CSCs), and may be used for treating and/or preventing tumor recurrence, metastasis, drug resistance, and/or radiotherapy resistance, as well as for anti-cancer therapies. Various TPP-related compounds validated for oxygen consumption inhibition (OCR), were non-toxic, and had little or no effect on ATP production in normal human fibroblasts. Yet these compounds selectively target adherent “bulk” cancer cells. These compounds also inhibit the propagation of CSCs in suspension. TPP-related compounds provide a novel chemical strategy for effectively targeting both i) “bulk” cancer cells and ii) CSCs, while specifically minimizing or avoiding off-target side-effects in normal cells, among other useful therapies.

Devices, systems and methods including magnetic structures

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

Antithrombotic diamines

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula (I).

Magnetic device with magnetic structure and micro-fluidic structure

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

Stylus input device utilizing a permanent magnet

A stylus (30) that operates utilizing magnetic fields, wherein a permanent magnet (32) is disposed within a passive stylus that is detectable by a plurality of magnetic sensors (10, 12) that remove the magnetic field of the stylus from the earth's relative magnetic field to thereby obtain vectors that are used in a triangulation equation to determine the location of the stylus (30) in two or three dimensions, depending upon the number of magnetic sensors (10, 12) that are used, wherein one set of magnetic sensors can be used as a reference for earth's magnetic field, and wherein each of the magnetic sensors includes a polarizing coil to change direction of sensitivity (14), a null coil (42) and a flipping coil (44).

Devices, systems and methods with magnetic structures

Eine magnetische Vorrichtung kann eine magnetische Struktur, eine Vorrichtungsstruktur und eine zugehörige Schaltung aufweisen. Die magnetische Struktur kann eine strukturierte Materialschicht mit einer vorbestimmten magnetischen Eigenschaft aufweisen. Die strukturierte Schicht kann dazu konfiguriert sein, z. B. ein Magnetfeld zu schaffen, ein Magnetfeld zu erfassen, einen Magnetfluss zu lenken oder zu konzentrieren, eine Komponente vor einem Magnetfeld abzuschirmen oder eine magnetisch betätigte Bewegung zu schaffen usw. Die Vorrichtungsstruktur kann eine andere Struktur der Vorrichtung sein, die mit der magnetischen Struktur physikalisch verbunden oder relativ zu dieser angeordnet ist, z. B. um die magnetische Struktur strukturell abzustützen, deren Betrieb zu ermöglichen oder anderweitig diese in die magnetische Vorrichtung zu integrieren usw. Die zugehörige Schaltung kann mit der magnetischen Struktur elektrisch verbunden sein, um Signale der magnetischen Struktur zu empfangen, zu liefern, aufzubereiten oder zu verarbeiten. A magnetic device may include a magnetic structure, a device structure, and associated circuitry. The magnetic structure may include a patterned material layer having a predetermined magnetic property. The structured layer may be configured to e.g. For example, to create a magnetic field, detect a magnetic field, direct or concentrate a magnetic flux, shield a component from a magnetic field, or provide magnetically-actuated movement, etc. The device structure may be another structure of the device that has the magnetic structure is physically connected or arranged relative to this, z. For example, to structurally support the magnetic structure, enable it to operate, or otherwise integrate it into the magnetic device, etc. The associated circuitry may be electrically connected to the magnetic structure to receive, deliver, condition, or access signals of the magnetic structure to process.

Modules and methods including magnetic sensing structures

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

Devices, systems and methods including magnetic structures

A magnetic device may include a magnetic structure, a device structure, and an associated circuit. The magnetic structure may include a patterned layer of material having a predetermined magnetic property. The patterned layer may be configured to, e.g., provide a magnetic field, sense a magnetic field, channel or concentrate magnetic flux, shield a component from a magnetic field, or provide magnetically actuated motion, etc. The device structure may be another structure of the device that is physically connected to or arranged relative to the magnetic structure to, e.g., structurally support, enable operation of, or otherwise incorporate the magnetic structure into the magnetic device, etc. The associated circuit may be electrically connected to the magnetic structure to receive, provide, condition or process of signals of the magnetic device.

Combined microscope objective and microwave wire for optically detected magnetic resonance imaging

A microscope objective is disclosed comprising: a lens; a housing; a lens holder that is arranged to couple the lens to the housing; a first conductor and a second conductor, the first conductor and the second conductor extending along a sidewall of the housing, the first conductor and the second conductor being arranged to form at least one loop that is that is disposed about at least a portion of a perimeter of a field of view of the lens.

Method for solid state genome analysis

The invention is a solid state process for analyzing genomes by visualizing sequence specific markers (e.g., proteins that bind a defined DNA sequence elements) by scanning probe microscopy. The method includes linear display of the nucleic acid on a solid surface, image acquisition by the scanning probe microscope, and digital data analysis. The acts of the method result in a bar code type display of each fragment of the DNA sample. These bar codes are then used to place the fragments in the order they appear on the original DNA sample.

Method and apparatus for solid state molecular analysis

The invention is a method for the formation and analysis of novel miniature deposition domains. These deposition domains are placed on a surface to form a molecular array. The molecular array is scanned with an AFM to analyze molecular recognition events and the effect of introduced agents on defined molecular interactions. This approach can be carried out in a high throughput format, allowing rapid screening of thousands of molecular species in a solid state array. The procedures described here have the added benefit of allowing the measurement of changes in molecular binding events resulting from changes in the analysis environment or introduction of additional effector molecules to the assay system. The processes described herein are extremely useful in the search for compounds such as new drugs for treatment of undesirable physiological conditions. The method and apparatus of the present invention does not require the labeling of the deposition material or the target sample and may also be used to deposit large size molecules without harming the same.

Systems and Methods to Identify Metabolic Subphenotypes and Uses Thereof

Systems and methods to assess metabolic dysregulation are described. Metabolic dysregulation refers to elevated glycemia or insulin resistance. The systems and methods assess metabolic dysregulation by determining which subphenotypes or underlying pathologies are contributing to the metabolic dysregulation. In some instances, a trained computational model utilizes an individual's glucose time series curve to determine the contribution of various metabolic dysregulation subphenotypes to the individual's metabolic dysregulation. Various applications or treatments can be performed based on the determination of metabolic dysregulation subphenotypes.

Implantable limb lengthening nail driven by a shape memory alloy

An implantable intramedullary bone lengthening device for correction of limb length deficiencies without a need for transcutaneous connections. The implantable intramedullary bone lengthening nail has an implantable housing, an adjustment mechanism attached to the telescoping cylinder housing, and a drive assembly attached to the housing and the adjustment mechanism for transmitting an expansion force to the adjustment mechanism. The implantable housing may be sealed, encapsulating the unit. The intramedullary bone lengthening nail is inserted into the intramedullary cavity of a bone, which may have been enlarged by reaming. The implantable housing of the intramedullary nail is formed from two telescoping cylinders and is affixed at either end to the bone using pins. The adjustment mechanism is attached to both cylinders of the housing and includes a mechanism for expanding the nail and a ratcheting mechanism for regulating the expansion. The drive assembly includes a shape memory alloy to provide an expansion force. The drive mechanism transmits the expansion force in response to an external signal to the adjustment mechanism.

Method and apparatus for uniformly adding particulates to a coating on comestibles, and products produced thereby

A process for applying particulates to a large number of comestible cores during the production of comestible cores so as to have a generally uniform application of particulates on each coated core involves the steps of placing a batch of comestible cores in a coating apparatus; applying aliquots of coating syrup while the cores are tumbled in the coating apparatus to build up a coating on the cores; dividing a predetermined total amount of the particulates to be applied to the coated cores into at least three portions of approximately equal size; and applying each of the portions of particulates to the coated cores simultaneously from multiple, spaced apart, particulate distributors in the coating apparatus while the coated cores are being tumbled. Preferably the particulate applicator comprises a number of venturi eductors equal to the number of particulate distributors; a pneumatic hose connected between each venturi eductor and each particulate distributor; and a vibratory pan for holding a quantity of particulates and causing the particulates to vibrate and flow at a uniform rate into each venturi eductor. The process is particularly were suited to uniformly apply speckle particulates to produce coated chewing gum or other confectionery cores with a uniform number of speckles on each core.

Method and apparatus for uniformly adding particulates to a coating on comestibles, and products produced thereby

A process for applying particulates to a large number of comestible cores during the production of comestible cores so as to have a generally uniform application of particulates on each coated core involves the steps of placing a batch of comestible cores in a coating apparatus; applying aliquots of coating syrup while the cores are tumbled in the coating apparatus to build up a coating on the cores; dividing a predetermined total amount of the particulates to be applied to the coated cores into at least three portions of approximately equal size; and applying each of the portions of particulates to the coated cores simultaneously from multiple, spaced apart, particulate distributors in the coating apparatus while the coated cores are being tumbled. Preferably the particulate applicator comprises a number of venturi eductors equal to the number of particulate distributors; a pneumatic hose connected between each venturi eductor and each particulate distributor; and a vibratory pan for holding a quantity of particulates and causing the particulates to vibrate and flow at a uniform rate into each venturi eductor. The process is particularly were suited to uniformly apply speckle particulates to produce coated chewing gum or other confectionery cores with a uniform number of speckles on each core.

Reduced side-effect hemoglobin compositions

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Reduced side-effect hemoglobin compositions

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Water resistant cementitious article and method for preparing same

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

Mat-faced gypsum board and method of making thereof

A mat-faced gypsum board and method of making thereof is provided having a particulate matter applied on an inner surface of the facer mat and extending partially into the mat from the inner surface thereof. The particulate matter, which is preferably a hydratable powder such as calcium sulfate hemihydrate, minimizes and, preferably, prevents bleed through of a gypsum slurry during formation of the gypsum board.

Cementitious article and method for preparing the same

A cementitious article and a method of making a cementitious article are disclosed. The cementitious article comprises a cementitious component that comprises a polyvinyl acetate type polymer, a monobasic phosphate, and optionally boric acid. Cementitious articles, such as board, are prepared such that the polyvinyl acetate type polymer, the monobasic phosphate, and optionally boric acid can be present in the cementitious core, and/or in dense layers if present. The concentration of the polyvinyl acetate type polymer, monobasic phosphate, and optionally boric acid in the cementitious article can increase from a central region A to peripheral regions B and C, respectively. In some embodiments, the polyvinyl acetate type polymer is a polyvinyl alcohol and the monobasic phosphate is monoammonium phosphate.

Water resistant cementitious article and method for preparing same

A fibrous mat-faced cementitious article comprising (a) a cementitious core, and (b) a first fibrous mat comprising polymer or mineral fibers and a hydrophobic finish on at least one surface thereof, wherein the hydrophobic finish is in contact with the cementitious core, and a method of preparing a fibrous mat-faced cementitious article, as well as a method of preparing a water-resistant cementitious article comprising (a) preparing an aqueous siloxane dispersion, wherein the dispersion comprises about 4 wt. % to about 8 wt. % siloxane, (b) combining the siloxane dispersion with a cementitious mixture to provide a cementitious slurry, (c) depositing the cementitious slurry onto a substrate, and (d) allowing the cementitious slurry to harden, thereby providing a cementitious article.

Reprogrammable subscriber terminal

A reprogrammable subscriber terminal of a subscription television service which can have the control program code of its control processor modified by downloading new program code from the headend. The control processor stores a boot program in an internal read only memory. Upon start up and resets, the boot program determines whether the control program should be changed from a command sent from the headend. The command, termed a parameters transactions, includes the number of expected download program code transactions required to complete the control code modification, the memory space areas where the code is to be loaded, and the channel over which the download program code transactions are to be transmitted. The channel is tuned and when the boot program receives all the download program code transactions accurately and stores them, the boot program will cause the control program to be restarted at a selected address of the new or modified control program code which has been downloaded. The boot program may download code to different configurations of subscriber terminals including those with Flash EPROM or extended memories from plug-in expansion modules.

Method of enantioselectively inserting a carbene

A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes a two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation.

Low profile valve locking mechanism and commissure assembly

A replacement heart valve locking mechanism may include a buckle member fixedly attached to a tubular anchor member defining a central longitudinal axis, a post member axially translatable relative to the buckle member, and an actuator member releasably connected to the post member at an attachment point. The post member may include a latch portion configured to engage a catch formed in the buckle member such that movement of the post member distally relative to the buckle member is prevented. The attachment point may be disposed proximal of the latch portion. Circumferential translation of the latch portion about the central longitudinal axis may disengage the latch portion from the catch.

Medical device handle

A medical device handle may include a handle housing including a cavity disposed within the handle housing. The medical device handle may include a carriage assembly disposed within the cavity and operatively connected to the tubular member and the medical implant, the carriage assembly being longitudinally movable between a distal position and a proximal position by rotation of a control knob with respect to the handle housing, the control knob being disposed around a proximal end of the handle housing. The carriage assembly may include a carriage member, a first sliding member, a second sliding member, and a locking element configured to releasably fix the first sliding member and the second sliding member relative to the carriage member. The locking element may be rotatable relative to the handle housing.

Replacement heart valve implant with invertible leaflets

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

Heart valve implant commissure support structure

A replacement heart valve implant defining a central longitudinal axis extending from an upstream end to a downstream end may include an expandable anchor member configured to shift between a delivery configuration and a deployed configuration, a circumferential support member distinct from and attached to the expandable anchor member, at least a portion of the circumferential support member extending downstream of the expandable anchor member, and a plurality of valve leaflets secured to the expandable anchor member. The plurality of valve leaflets may include a valve leaflet commissure movable from a first longitudinal position relative to the downstream end in the delivery configuration to a second longitudinal position relative to the downstream end in the deployed configuration.

Medical implant locking mechanism

A medical device system may include a replacement heart valve implant including an expandable anchor member reversibly actuatable between a delivery configuration and a deployed configuration, wherein the replacement heart valve implant includes at least one locking mechanism configured to lock the expandable anchor member in the deployed configuration, and at least one actuator element configured to releasably engage the at least one locking mechanism and actuate the expandable anchor member between the delivery configuration and the deployed configuration. The at least one actuator element may include external threads on a distal portion of each actuator element and a ramp disposed proximal of the external threads.

Replacement heart valve commissure assembly

A replacement heart valve commissure assembly may include a locking mechanism including a first locking portion spaced apart from a second locking portion in a delivery configuration and configured to engage with the second locking portion in a deployed configuration, wherein the first locking portion is longitudinally actuatable relative to the second locking portion between the delivery and deployed configurations. The commissure assembly may include a first valve leaflet and a second valve leaflet each secured to the first locking portion. A first sleeve portion of the first valve leaflet may be fixedly attached to a first fabric sleeve wrapped around a first leg of the first locking portion by a first filament, and a second sleeve portion of the second valve leaflet may be fixedly attached to a second fabric sleeve wrapped around a second leg of the first locking portion by a second filament.

System and method for cardiac valve repair and replacement

A prosthetic mitral valve includes a proximal anchor, a distal anchor, and a central portion therebetween. The proximal and distal anchors each include a first outer frame and a second outer frame. The first outer frame includes a plurality of first arcs joined together, and the second outer frame includes a plurality of second arcs joined together. The plurality of first arcs are out of phase relative to the plurality of second arcs.

Medical device handle

A medical device handle for percutaneous delivery of a medical device implant may include an elongated handle housing having a proximal end, a distal end, and a longitudinal axis extending from the proximal end to the distal end; a rotatable collar disposed about the proximal end of the handle housing; and a rotatable control knob disposed about a proximal portion of the rotatable collar. The rotatable collar may include a first internally-facing longitudinal slot extending less than a full length of the rotatable collar and terminating proximally at a distally-facing wall of an internally-facing circumferentially-oriented slot. The rotatable control knob may be configured to actuate the medical device implant between a delivery configuration, a deployed configuration, and a released configuration.

Containment vessel with implant sheathing guide

A containment vessel for storing and rinsing a medical implant coupled to a delivery system having an outer sheath may include a hollow element having a wall, a proximal end, a distal end, and a lumen extending between the proximal end and the distal end, the lumen of the hollow element being configured and adapted to contain a medical implant in a partially-deployed configuration during storage and rinsing of the medical implant and a proximal end cap including a secondary proximal end cap removably secured to the proximal end cap and configured to reversibly seal the proximal end cap to the outer sheath, thereby establishing a closed fluid connection between the lumen of the hollow element and a lumen of the outer sheath. The proximal end cap may include a sheathing guide configured and adapted to direct the medical implant into the lumen of the outer sheath.

System and method for cardiac valve repair and replacement

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

System and method for cardiac valve repair and replacement

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

System and method for cardiac valve repair and replacement

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

System and method for cardiac valve repair and replacement

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

System and method for cardiac valve repair and replacement

A prosthetic mitral valve comprising an expandable anchor comprising a first anchor, a central portion and a second anchor; wherein the first anchor comprises a first outer frame and a second outer frame, the first outer frame comprising a plurality of first arcs joined together, and the second outer frame comprising a plurality of second arcs joined together, wherein the plurality of first arcs are out of phase relative to the plurality of second arcs when the first anchor is viewed in an end view from the first anchor to the second anchor; and a plurality of replacement leaflets secured to the expandable anchor.

Replacement cardiac valves and methods of use and manufacture

Prosthetic mitral valves and their methods of manufacture and use.

Medical device handle

A medical device handle may include a handle housing including a cavity disposed within the handle housing. The medical device handle may include a carriage assembly disposed within the cavity and operatively connected to the tubular member and the medical implant, the carriage assembly being longitudinally movable between a distal position and a proximal position by rotation of a control knob with respect to the handle housing, the control knob being disposed around a proximal end of the handle housing. The carriage assembly may include a carriage member, a first sliding member, a second sliding member, and a locking element configured to releasably fix the first sliding member and the second sliding member relative to the carriage member. The locking element may be rotatable relative to the handle housing.

Replacement heart valve implant with invertible leaflets

A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.

Electronic filters, hearing aids and methods

An electronic filter for an electroacoustic system. The system has a microphone for generating an electrical output from external sounds and an electrically driven transducer for emitting sound. Some of the sound emitted by the transducer returns to the microphone means to add a feedback contribution to its electical output. The electronic filter includes a first circuit for electronic processing of the electrical output of the microphone to produce a filtered signal. An adaptive filter, interconnected with the first circuit, performs electronic processing of the filtered signal to produce an adaptive output to the first circuit to substantially offset the feedback contribution in the electrical output of the microphone, and the adaptive filter includes means for adapting only in response to polarities of signals supplied to and from the first circuit. Other electronic filters for hearing aids, public address systems and other electroacoustic systems, as well as such systems, and methods of operating them are also disclosed.

Caffeine coated chewing gum product and process of making

A method for producing a chewing gum with a controlled release of caffeine, as well as the chewing gum so produced, is obtained by physically modifying caffeine's properties by coating and drying. Caffeine is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated caffeine is then preferably co-dried and particle sized to produce a release-modified caffeine for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. Also disclosed is a chewing gum pellet having a coating including caffeine or a caffeine salt compound.

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.

Preparation of biopolymer arrays

A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.

Chewing gum containing medicament active agents

A method for producing a chewing gum with a controlled release active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the active agent by coating and drying. The active agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated active agent is preferably then co-dried and particle sized to produce a release-modified active agent for use in chewing gum. The active agent may also be used in a coating on a chewing gum product, as part of a rolling compound applied to the chewing gum product, or as a part of the liquid in a liquid-center chewing gum product.

Quantum dot thermoelectric materials and devices

Quantum-dot superlattice (QLSL) structures having improved thermoelectric properties are described. In one embodiment, PbSe x Te 1−x /PbTe QDSLs are provided having enhanced values of Seebeck coefficient and thermoelectric figure of merit (ZT) relative to bulk values.

Nanostructured thermoelectric materials and devices

Quantum-dot superlattice (QLSL) structures having improved thermoelectric properties are described. In one embodiment, PbSe x Te 1-x /PbTe QDSLs are provided having enhanced values of Seebeck coefficient and thermoelectric figure of merit (ZT) relative to bulk values. The structures can be combined into multi-chip devices to provide additional thermoelectric performance.

Laminated sheets for use in a fully retrievable occlusion device

An occlusion device having laminated polyvinyl alcohol sheets for occluding a defect. The laminated polyvinyl alcohol sheets provide an increased tear strength to the sheets that allows the device to be fully retrievable through the same catheter used to deploy it. The laminated sheets are created by obtaining thin sheets of polyvinyl alcohol foam, arranging the sheets on one another, and applying heat and pressure to laminate the sheets together.

Method of producing active agent coated chewing gum products

A method for producing a chewing gum with an improved release of active agent, as well as the chewing gum so produced, is obtained by adding an active agent to a chewing gum coating. The active agent is added to the coating in a coating solution or premixed with a flavor or solvent. The coating solution may contain sweetener or other transdermal enhancing agents to obtain increased transmucosal absorption. An active agent may also be used in the gum core.

Adaptive gain and filtering circuit for a sound reproduction system

Adaptive compressive gain and level dependent spectral shaping circuitry for a hearing aid include a microphone to produce an input signal and a plurality of channels connected to a common circuit output. Each channel has a preset frequency response. Each channel includes a filter with a preset frequency response to receive the input signal and to produce a filtered signal, a channel amplifier to amplify the filtered signal to produce a channel output signal, a threshold register to establish a channel threshold level, and a gain circuit. The gain circuit increases the gain of the channel amplifier when the channel output signal falls below the channel threshold level and decreases the gain of the channel amplifier when the channel output signal rises above the channel threshold level. A transducer produces sound in response to the signal passed by the common circuit output.

Adaptive gain and filtering circuit for a sound reproduction system

Personalized event detection methods and related devices and systems

Medical devices and related patient management systems and event detection methods are provided. An exemplary method of detecting events pertaining to operation of a medical device, such as an infusion device, involves obtaining measurements indicative of a condition in a body of a patient, determining statistics for an analysis interval based on the measurements, and determining an event probability associated with the analysis interval based on historical event data associated with the patient. An event detection model associated with the patient is obtained and applied to the statistics and the event probability to identify occurrence of the event using the event detection model, and in response, an indication of the event associated with the analysis interval is provided, for example, by tagging or marking data in a database, displaying graphical indicia of the event, or the like.

Data analytics and insight delivery for the management and control of diabetes

A computer-implemented system and related method of managing use of a diabetes management device are presented here. An embodiment of the method obtains input data for a user of the diabetes management device, and compares the input data against historical event/outcome combinations maintained for the user. Each of the event/outcome combinations includes insight event data indicative of a glycemic event and a glycemic outcome corresponding to the insight event data. The method determines, based on the comparing, a correlation between the input data and a glycemic outcome. The method continues by generating a glycemic insight message for delivery to the user, wherein the glycemic insight message includes information regarding a relationship between at least some of the input data and the glycemic outcome.

Matrices with memories

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, sensors and drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided. Sensors containing a memory in combination with a matrix are also provided.

Electric gear motor drive for switching valve

Electric drive for a switching valve, the switching valve having such a drive, and a regenerative thermal oxidizer including the switching valve and drive system. The electric drive system allows for the starting and stopping of the rotation of a rotary valve with accurate positioning. The stopping of the valve includes dissipation of the kinetic energy of the valve by electric means. The valve is allowed to move vertically and oscillating rotary motion is possible. The drive system preferably includes a gear, gearbox, variable speed drive and at least one positioning sensor. Valve acceleration and deceleration can be carried out in a controlled fashion and with repeatability, so that the final end position of the valve is consistent. The accommodation of vertical movement of the valve is also within the scope of the present invention.

Improved release of medicament active agents from a chewing gum coating

A method for producing a chewing gum with an improved release of active agent, as well as the chewing gum so produced, is obtained by adding an active agent to a chewing gum coating. The active agent is added to the coating in a coating solution or premixed with a flavor or solvent. The coating solution may contain sweetener or other transdermal enhancing agents to obtain increased transmucosal absorption. An active agent may also be used in the gum core.

Method and apparatus for liquid transfer

Liquids are transferred from a plurality of wells or depots having openings arranged in a selected format to one or more receptacles, by displacing liquid contained in each well so that a convex meniscus swells from the opening, and contacting the receptacle with the swollen meniscus to draw a portion of the liquid into the receptacle. According to the invention, the liquid transfer is effected directly from the depot to the corresponding receptacle without contact between depots and receptacles, and without interposition of any transfer device between depots and receptacles. Apparatus for carrying out the method includes a depot member having a plurality of wells having openings supported in a selected format, and a receiving member defining at least one receptacle and usually a plurality of receptacles in a corresponding or complementary format; a device for displacing liquid contained within the wells toward and through the openings; and a device for bringing at least one selected well opening into proximity with at least one selected receptacle. In some embodiments the liquid is displaced by inwardly deforming portions of the walls of the wells; in other embodiments the liquid is displaced by introducing a displacing fluid into the wells at a point away from the openings. The inventions is particularly useful in transferring a multiplicities of liquids from preparative or storage depots to receptacles formed in planar members such as planar microfluidics devices or printing devices adapted for deposition of materials in microarrays.

Automated sorting system for matrices with memory

Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.

Hoop design for occlusion device

The present invention is an occlusion device having a support hoop. The support hoop increases the ability of the occlusion device to form a seal around the defect and adds additional structural strength to the device by allowing distribution of pressure along a 360° continuum.

Flexible medical device

This invention relates to flexible medical device. The flexible medical device may comprise interlocking portions formed of a continuous channel. When formed of a continuous channel, the medical device comprises interconnected interlocking portions, rather than independent interlocking portions. The flexible medical device may also be designed so that different portions of the device have different flexibility characteristics.

Flexible delivery device

This invention relates to catheter delivery systems, and more specifically, to a tubular device with improved torque and flexure characteristics. The present invention is a tubular device having improved torque and flexure characteristics which uses a series of permanently interlocking independent segments to provide the necessary torque and flexure characteristics.

Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids

Methods are provided for depositing a quantity of fluid onto the surface of an array. In the subject methods, a thermal inkjet head loaded with the fluid is positioned in opposing relationship to, e.g. over, the array surface. Actuation of the thermal inkjet results in the expulsion of a quantity of fluid onto the array surface. The subject methods find particular use in array-based binding assays in which an array of binding agents is employed for the detection of an analyte(s), particularly array-based hybridization assays.

Methods of fabricating an addressable array of biopolymer probes

A method of fabricating an addressable array of biopolymer probes on a substrate according to a target array pattern using a deposition apparatus, and a deposition apparatus which can execute the method and computer program products for the apparatus. The deposition apparatus which, when operated according to a target drive pattern based on nominal operating parameters of the apparatus, provides the probes on the substrate in the target array pattern. The method includes examining at least one operating parameter for an error from a nominal value which error will result in use of the target drive pattern producing a discrepancy between the target array pattern and an actual array pattern deposited. When an error is detected deriving, based on the error, a corrected drive pattern different from the target drive pattern such that use of the corrected drive pattern results in a reduced discrepancy between the target and actual array patterns.

New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors

The present invention relates to novel pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.

Pharmaceutical combinations containing benzoxazine for treating respiratory diseases

The invention relates to novel pharmaceutical combinations containing at least one active ingredient (2) in addition to at least one, preferably one, compound of general formula (1) wherein the radicals R1, R2 and R3 have the designations cited in the patent claims and in the description. The invention also relates to a method for producing said combinations and to the use thereof as medicaments.

Composition comprising a steroid and an anticholinergic agent

New medicaments contain a quaternized 2,2-diphenylpropionic acid scopine ester anticholinergic agent (I) and a beta -mimetic agent (II). New medicaments contain: (a) a scopine derivative anticholinergic agent of formula (I); (b) at least one beta -mimetic agent (II) (optionally in the form of enantiomers, enantiomer mixtures, racemates, solvates or hydrates); and optionally (c) pharmaceutical auxiliaries. [Image] X ->monovalent anion, preferably chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulfonate. ACTIVITY : Antiinflammatory; Antiasthmatic. MECHANISM OF ACTION : Anticholinergic; Synergist.

Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases

The present invention relates to novel pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.

Novel pharmaceutical combinations for the treatment of respiratory disorders

The present invention relates to novel pharmaceutical combinations which, besides one or more, preferably one, compound of the general formula (1) in which the radicals R1, R2 and R3 have the meanings stated in the claims and in the description, comprise at least one further active ingredient 2, method for the manufacture thereof, and the use thereof as pharmaceutical.

Medicaments for inhalation comprising betamimetics and an anticholinergic

The present invention relates to novel pharmaceutical compositions based on beta 2 agonists and salts of an anticholinergic, processes for preparing them and their use in the treatment of respiratory complaints.

New medicine combinations for treating respiratory diseases

A composition comprises at least one 6-hydroxy-4H-benzo[1,4]oxazin-3-one derivative and at least one other active substance. A composition comprises at least one 6-hydroxy-4H-benzo[1,4]oxazin-3-one compounds of formula (I) and at least one other active substance. n : 1 or 2; R 1 and R 2 : H, halo, 1-4C alkyl or -O-1-4C alkyl;and R 3 : 1-4C alkyl, OH, halo, -O-1-4C alkyl, -O-1-4C alkylene-COOH or -O-1-4C alkylene-CO-O-1-4C alkyl. [Image] ACTIVITY : Antiinflammatory; Respiratory-Gen.; Antiasthmatic; Dermatological; Immunosuppressive; Antiallergic; Cardiant; Vasotropic. MECHANISM OF ACTION : None given.

Inhalation medicament containing a novel anticholinesterase drug, formoterol and a steroid

The invention relates to novel medicament compositions based on a novel anticholinesterase drug, formoterol salts and on a corticosteroid, to a method for the production thereof and to their use for treating respiratory disorders.

Matrices with memories and uses thereof

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.