27-12-2018 дата публикации
Номер: US20180369163A1
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including , methicillin-resistant and . The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics. 1. A method for treating or preventing a bacterial infection , comprising administering to a subject in need thereof an effective amount of a compound comprising an S-heterosubstituted disulfide having formula (I):{'sub': 1', '2, 'XSSX(I)'}{'sub': 1', '2', '1', '2, 'wherein each Xand Xare concurrently S—Ror N—R;'}{'sub': '1', 'wherein Ris isopropyl, butyl, s-butyl, or phenyl; and'}{'sub': '2', 'wherein Ris s-butyl.'}2. The method of claim 1 , further comprising a pharmaceutically acceptable carrier.3. The method of claim 1 , wherein Xand Xare S—R.4. The method of claim 3 , wherein Ris phenyl.5Staphylococcus aureus.. The method of claim 1 , wherein the bacteria is6Staphylococcus aureus.. The method of claim 5 , wherein the bacteria is methicillin-resistant7Francisella tularensis.. The method of claim 1 , wherein the bacteria is This application is a continuation of and claims priority to currently pending U.S. Nonprovisional application Ser. No. 15/349,475, entitled “Antibacterial S-Heterosubstituted Disulfides”, filed Nov. 11, 2016, which is a continuation of and claims priority to U.S. Nonprovisional application Ser. No. 12/765,272, entitled, “Antibacterial S-Heterosubstituted Disulfides”, filed Apr. 22, 2010, now U.S. Pat. No. 9,512,160, which is a continuation of and claims priority to International Application Number PCT/US2008/081125, entitled, “Antibacterial S-Heterosubstituted Disulfides”, filed Oct. 24, 2008, which claims priority to U.S. Provisional Patent Application No. 60/982,403 entitled, “Antibacterial S-Heterosubstituted Disulfides”, filed Oct. 24, ...
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