17-11-2016 дата публикации
Номер: US20160332999A1
The present invention provides a compound represented by the formula (I): 4. The compound or pharmaceutically acceptable salt according to claim 3 , whereinQ is ═O;{'sub': 4', '1-6, 'Ris hydrogen or a Calkyl group;'}{'sub': 5', '1-6, 'Ris hydrogen or a Calkyl group;'}{'sub': 4', '5, 'provided that Rand Rare not joined to form cycloalkane; and'}X is hydrogen,-Cy,{'sub': x1', 'x2, '—C(RR)-Cy,'}{'sub': x1', 'x2', 'x3', 'x4, '—C(RR)—C(RR)-Cy,'}{'sub': x1', 'x2, '—C(R)═C(R)-Cy,'}—O-Cy,{'sub': x1', 'x2, '—O—C(RR)-Cy,'}{'sub': x1', 'x2, '—C(RR)—O-Cy,'}—S(O)n-Cy,{'sub': x1', 'x2, '—S(O)n-C(RR)-Cy,'}{'sub': x1', 'x2, '—C(RR)—S(O)n-Cy,'}{'sub': 'x5', '—N(R)-Cy,'}{'sub': x5', 'x1', 'x2, '—N(R)—C(RR)-Cy,'}{'sub': x1', 'x2', 'x5, '—C(RR)—N(R)-Cy,'}{'sub': x5', 'x6, '—N(R)—N(R)-Cy,'}{'sub': 'x5', '—O—N(R)-Cy,'}{'sub': 'x5', '—N(R)—O-Cy,'}{'sub': 'x5', '—C(O)—N(R)-Cy,'}{'sub': 'x5', '—N(R)—C(O)-Cy,'}{'sub': 'x5', '—S(O) m-N(R)-Cy, or'}{'sub': 'x5', '—N(R)—S(O)m-Cy.'}5. The compound or pharmaceutically acceptable salt according to claim 2 , wherein Ris hydrogen claim 2 , Ris a Calkyl group claim 2 , and Ris hydrogen.6. The compound or pharmaceutically acceptable salt according to claim 4 , wherein Y is —CH— claim 4 , Z is —CH— claim 4 , W is a bond claim 4 , and Ris hydrogen.7. The compound or pharmaceutically acceptable salt according to claim 4 , wherein Y is —CH— claim 4 , Z is a bond claim 4 , W is a bond claim 4 , and Ris hydrogen.9. The compound or pharmaceutically acceptable salt according to claim 8 , wherein Ris hydrogen.10. The compound or pharmaceutically acceptable salt according to claim 9 , wherein Rand Rare both hydrogen.11. The compound or pharmaceutically acceptable salt according to claim 9 , wherein ring A is a 6-membered monocyclic aromatic ring or a 6-membered monocyclic heteroaromatic ring.12. The compound or pharmaceutically acceptable salt according to claim 9 , wherein ring A is benzene claim 9 , pyridine claim 9 , or pyrimidine.14. The compound or ...
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