14-05-2015 дата публикации
Номер: US20150133326A1
Принадлежит:
Disclosed herein is a method for determining recovered heart function in a subject based in the biomarker ceruloplasmin in patient samples. Also disclosed are computer systems, kits and software. 13.-. (canceled)4. A method for determining recovered heart function a subject , comprising:obtaining a first dataset associated with a first sample obtained from a subject before treatment, wherein the first dataset comprises at least one marker selected from Table 1;obtaining a second dataset associated with a second sample obtained from the subject after treatment, wherein the second dataset comprises at least one marker selected from Table 1;analyzing the first and second datasets to determine data for the markers, wherein the data is positively correlated or negatively correlated with recovered heart function in the subject.5. The method of claim 4 , wherein the first dataset comprises data for at least two claim 4 , three claim 4 , four claim 4 , five claim 4 , six claim 4 , seven claim 4 , eight claim 4 , nine claim 4 , ten claim 4 , eleven claim 4 , twelve claim 4 , thirteen claim 4 , fourteen claim 4 , fifteen claim 4 , sixteen claim 4 , seventeen claim 4 , eighteen claim 4 , nineteen claim 4 , twenty or more markers selected from Table 1 claim 4 ,and wherein the second dataset comprises data for at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen, sixteen, seventeen, eighteen, nineteen, twenty or more markers selected from Table 1;and further comprising analyzing the first and second datasets to determine the expression level of the at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen, sixteen, seventeen, eighteen, nineteen, twenty or more markers selected from Table 1.6. The method of claim 5 , further comprising determining recovered heart function in the subject according to the relative number of positively correlated and negatively correlated marker ...
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