Wrappable sterile radiation shield drape, combination of a radiation shield and sterile drape therefor and method of providing a sterile drape about a radiation shield

A wrappable sterile radiation shield drape, a wrappable sterile radiation shield drape in combination with a radiation shield, and a method of providing a sterile surface about a suspended radiation shield is provided. The drape includes a flexible wall having a sterilized outer surface. The wall has opposite side edges extending between upper and lower ends. The upper end has an everted portion providing an inverted pocket. The wall includes an upper fastener adjacent its upper end. The upper fastener is configured to releasably fix the upper end of the wall relative to the radiation shield. The wall further includes an edge fastener adjacent at least one of its side edges. The edge fastener is configured for releasable attachment adjacent the opposite side edge to releasably maintain the wall in a wrapped configuration about the radiation shield with the side edges being releasably maintained in overlapping relation with one another.

Master/slave arrangement of an electronic engine control device with engine identification module

A master/slave arrangement of an electronic engine control device with an engine identification module. The electronic engine control device controls and regulates the internal combustion machine. The engine identification module includes at least one microprocessor and a memory building block for storing an engine identification as well as engine specifics. The electronic engine control device and the engine identification module exchange data through an engine cable harness. The engine identification module is arranged inseparably at the crank housing of the internal combustion machine. The engine identification module can be removed from the crank housing as well as from the engine cable harness only by being destroyed.

FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS

Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.

PRODUCTION OF POLYUNSATURATED FATTY ACIDS BY COEXPRESSION OF ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES AND PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASES

Acyl-CoA:lysophosphatidylcholine acyltransferase [“LPCAT”] having the ability to convert acyl-CoA+1-acyl-sn-glycero-3-phosphocholine to CoA+1,2-diacyl-sn-glycero-3-phosphocholine (EC 2.3.1.23) is disclosed herein to be over-expressed along with the over-expression of phospholipid:diacylglycerol acyltransferase [“PDAT”] having the ability to transfer a fatty acyl group from the sn-2 position of a phospholipid (e.g., phosphatidylcholine) to the sn-3 position of 1,2-diacylglycerol [E.C.2.3.1.158], thus resulting in a lysophospholipid and TAG. Co-expression of these enzymes in a recombinant microbial host cell resulted in increased production of long chain polyunsaturated fatty acids [“PUFAs”].

MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES

Mutant acyl-CoA:lysophosphatidylcholine acyltransferases [“LPCATs”] having the ability to convert acyl-CoA+1-acyl-sn-glycero-3-phosphocholine to CoA+1,2-diacyl-sn-glycero-3-phosphocholine (EC 2.3.1.23) are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant LPCATs, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant LPCATs in oleaginous yeast, are also disclosed.

Network-related performance for gpus

Techniques for improved networking performance in systems where a graphics processing unit or other highly parallel non-central-processing-unit (referred to as an accelerated processing device or “APD” herein) has the ability to directly issue commands to a networking device such as a network interface controller (“NIC”) are disclosed. According to a first technique, the latency associated with loading certain metadata into NIC hardware memory is reduced or eliminated by pre-fetching network command queue metadata into hardware network command queue metadata slots of the NIC, thereby reducing the latency associated with fetching that metadata at a later time. A second technique involves reducing latency by prioritizing work on an APD when it is known that certain network traffic is soon to arrive over the network via a NIC.

Furan based polyamides

Disclosed herein are compositions and article made therefrom and processes of making them. The composition comprises a polymer, the polymer comprising a repeat unit of formula shown below: wherein the polymer is derived from an aromatic diamine comprising m-phenylene diamine, and an aromatic diacid or a derivative thereof comprising furan dicarboxylic acid or derivative thereof.

Method for operating an internal combustion engine, internal combustion engine and maintenance system for an internal combustion engine, self-executable computer program product and non-volatile storage medium

A method for operating an internal combustion engine having a hardware structure including an engine control unit and a maintenance unit, an electronic engine identification module and an engine control program, the method having the steps: providing a computer program product via a network by which an engine identification and engine data are loaded together and are exchanged, wherein the computer program product is designed for uploading and/or downloading a maintenance software module by which the engine identification and the engine data are compiled; loading the computer program product onto a non-volatile storage medium; coupling the non-volatile storage medium to the maintenance unit of the hardware structure and executing the computer program product; exchanging the maintenance software module between the non-volatile storage medium and the maintenance unit; identifying the engine and compiling engine data by the maintenance software module and a hardware component of the hardware structure.

Wrappable sterile radiation shield drape, combination of a radiation shield and sterile drape therefor and method of providing a sterile drape about a radiation shield

A wrappable sterile radiation shield drape, a wrappable sterile radiation shield drape in combination with a radiation shield, and a method of providing a sterile surface about a suspended radiation shield is provided. The drape includes a flexible wall having a sterilized outer surface. The wall has opposite side edges extending between upper and lower ends and an upper fastener adjacent its upper end. The upper fastener is configured to releasably fix the upper end of the wall relative to the radiation shield. The wall further includes an edge fastener adjacent at least one of its side edges. The edge fastener is configured to releasably maintain the wall in a wrapped configuration about the radiation shield. The wall further includes at least one flap attached adjacent the upper end, wherein the flap includes a pocket configured to receive a shoulder extension portion of the radiation shield.

Methods of Suppressing Rheumatoid Arthritis Using an Anti-IL-6 Antibody

Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

System and method for consistent paper movement

A system and method for consistent paper movement includes a pick/feed motor configured to rotate a pick/feed roller of a print engine to deliver a sheet of paper to the registration nip of a registration roller. A first sensor and a second sensor disposed in the paper path between the pick/feed roller and the registration roller detect the leading edge of the paper. A controller receives sensor data from the first and second sensors and compares the sensor data with expected times for receiving the sensor data. When the received sensor data indicates that the paper is lagging or leading, the controller calculates a period of time to drive the drive the pick/feed motor at a higher or lower speed to compensate for the lagging or leading of the paper.

Methods for expressing polypeptides in hyperthermophiles

Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (T opt ) of the genetically engineered archaeon. Also provided herein are methods for using genetically engineered archaea and cell-free extracts of such genetically engineered archaea. In one embodiment, the methods include culturing a genetically engineered archaeon at a temperature that is at least 20° C. below the T opt of the genetically engineered archaeon, such that the activity in the genetically engineered archaeon of a polypeptide encoded by the coding region is increased compared to the activity in the genetically engineered archaeon of the polypeptide during growth at a second temperature that is at or near the T opt of the genetically engineered archaeon.

Angled ridges on electrostatic process unit shafts

A system and method for urging stray toner away from sealing areas on rotating shafts in electrostatic process units includes a shaft that is associated with a rotating component of the electrostatic process unit such as a toner mixer, a waste auger, a developer, or a photoconductive drum. The shaft includes sealing areas at either end of the shaft that are configured to prevent toner leakage through the sealing areas, and protruding ridges in the sealing areas that encircle the shaft. The protruding ridges are angled relative to the axis of the shaft such that rotation of the shaft causes the protruding ridges to urge stray toner away from the sealing areas. The protruding ridges substantially reduce toner leakage through the sealing areas of rotating shafts of electrostatic process units.

Genetically engineered microbes and methods for converting organic acids to alcohols

Disclosed herein are genetically engineered microbes. In one embodiment, a genetically engineered microbe includes a metabolic pathway for the production of an alcohol from an organic acid. For instance, a genetically engineered microbe converts acetate, butyrate, propionate, isobutyrate, valerate, isovalerate, caproate, or phenylacetate, to Ethanol, Butanol, Propanol, Isobutanol, 1-Pentanol, Isoamylalcohol, 1-Hexanol, Phenylethanol, respectively. Also provided herein are methods of using the microbes.

Print manager system and method for printer selection

A system and method for monitoring and managing printers includes receiving printer status data associated with a user print job from two or more networked multifunction peripherals. Print job data is compared to the received printer status data. A multifunction peripheral for executing the user's print job is identified in accordance with the comparison. Data identifying the multifunction peripheral includes a subset of the printer status data associated with the identified multifunction peripheral.

Grip tape for a sports implement

A grip for use with a sports implement extending about a longitudinal axis. The grip includes a flexible strip defining a length defining a major dimension and width defining a minor dimension. The strip has a butt end region, a primary region and a throat end region. The throat end region defines at least one guideline. The guideline extends along an outer surface of the strip at an angle with respect to a line that is parallel to the major dimension of the strip. The angle is arranged such that when the grip is wrapped about the sports implement, the guideline extends in a direction that is generally perpendicular to the longitudinal axis.

Zirconocene-titanocene catalyst system

A zirconocene-titanocene catalyst system comprising a zirconocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

Hafnocene-titanocene catalyst system

A hafnocene-titanocene catalyst system comprising a hafnocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

Zirconocene-titanocene catalyst system

A zirconocene-titanocene catalyst system comprising a zirconocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

Zirconocene-titanocene catalyst system

A zirconocene-titanocene catalyst system comprising a zirconocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

Catalyst composition for ethylene polymerization

Control of resin split in single-reactor manufacture of bimodal polyolefins

Bimodal resin products are produced in a single reactor by using two bicomponent catalyst compositions, each having a high molecular weight and a low molecular weight component, in different ratios. The HMW/LMW split of the final resin product is controlled accurately by controlling the ratio of the feed of the two bicomponent catalyst compositions. Bimodal or polymodal effects are also achieved for properties or characteristics other than molecular weight. More complex results can be achieved with more than two components. The invention is applicable to a wide variety of polymer products, particularly polyolefins and polyethylene.

Gas-phase polymerization process having multiple flow regimes

The present invention relates to an improvement for gas phase olefin polymerization process under two or more different flow regimes. The process involves adding a mixed electron donor system to a reactor having two or more different flow regimes, wherein the mixed electron donor system comprises at least one selectivity control agent and at least one activity limiting agent. The invention is particularly well suited for reactor systems which include a regime characterized by having a low-velocity or high-solid holdup, which have been reported to have operational problems such as particle agglomeration and formation of polymer "chunks".

Gas-phase polymerization process having multiple flow regimes

The present invention relates to an improvement for gas phase olefin polymerization process under two or more different flow regimes. The process involves adding a mixed electron donor system to a reactor having two or more different flow regimes, wherein the mixed electron donor system comprises at least one selectivity control agent and at least one activity limiting agent. The invention is particularly well suited for reactor systems which include a regime characterized by having a low-velocity or high-solid holdup, which have been reported to have operational problems such as particle agglomeration and formation of polymer “chunks”.

Gas-phase polymerization process having multiple flow regimes

The present invention relates to an improvement for gas phase olefin polymerization process under two or more different flow regimes. The process involves adding a mixed electron donor system to a reactor having two or more different flow regimes, wherein the mixed electron donor system comprises at least one selectivity control agent and at least one activity limiting agent. The invention is particularly well suited for reactor systems which include a regime characterized by having a low-velocity or high-solid holdup, which have been reported to have operational problems such as particle agglomeration and formation of polymer "chunks".

Gas-phase polymerization process having multiple flow regimes

The present invention relates to an improvement for gas phase olefin polymerization process under two or more different flow regimes. The process involves adding a mixed electron donor system to a reactor having two or more different flow regimes, wherein the mixed electron donor system comprises at least one selectivity control agent and at least one activity limiting agent. The invention is particularly well suited for reactor systems which include a regime characterized by having a low-velocity or high-solid holdup, which have been reported to have operational problems such as particle agglomeration and formation of polymer “chunks”.

Catalyst composition for ethylene polymerization

A process for the polymerization of olefin monomers comprising contacting ethylene or a mixture of ethylene and one or more C4-8 α olefins with a catalyst composition comprising one or more Group 3-10 transition metal containing, Ziegler-Natta, procatalyst compounds; one or more alkylaluminum cocatalyts; and one or more polymerization control agents, said process being characterized in that at least one such polymerization control agent is an alkyl or aryl. ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

Catalyst composition for ethylene polymerization

A process for the polymerization of olefin monomers comprising contacting ethylene or a mixture of ethylene and one or more C 4-8 α olefins with a catalyst composition comprising one or more Group 3-10 transition metal containing, Ziegler-Natta, procatalyst compounds; one or more alkylaluminum cocatalyts; and one or more polymerization control agents, said process being characterized in that at least one such polymerization control agent is an alkyl or aryl, ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

Ethylene polymerization using ziegler-natta catalyst compositions

Olefin monomers comprising contacting ethylene or a mixture of ethylene and one or more C 4-8 α-olefins are polymerized with a catalyst composition comprising one or more Group 3-10 transition metal containing, Ziegler-Natta, procatalyst compounds; one or more alkylaluminum cocatalyts; and at least one polymerization control agent that is an alkyl or aryl ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

Process of producing ethylene polymer blends in gas phase

A gas phase process for the production of a polyethylene blend comprising contacting ethylene and at least one alpha-olefin comonomer having 3 to 8 carbon atoms with a magnesium/titanium based catalyst system including an activator and a cocatalyst in each of two fluidized bed reactors connected in series, under polymerization conditions, with the provisos that: (a) the mixture of ethylene copolymer matrix and active catalyst formed in the first reactor in the series is transferred to the second reactor in the series; (b) other than the active catalyst referred to in proviso (a) and the cocatalyst referred to in proviso (e), no additional catalyst is introduced into the second reactor; (c) in the first reactor in which a low melt index copolymer is made: (1) the alpha-olefin is present in a ratio of about 0.01 to about 0.4 mole of alpha-olefin per mole of ethylene; (2) optionally, hydrogen is present in a ratio of about 0.001 to about 0.3 moles of hydrogen per mole of ethylene; and (3) the ethylene partial pressure is at least about 40 pounds per square inch; and (d) in the second reactor in which a high melt index copolymer is made: (1) the alpha-olefin is present in a ratio of about 0.01 to about 0.6 mole of alpha-olefin per mole of ethylene; (2) hydrogen is present in a ratio of about 1 to about 2.5 moles of hydrogen per mole of ethylene; and (3) diethyl zinc is added in an amount of about 2 to about 40 moles of diethyl zinc per mole of titanium; and (e) additional hydrocarbyl aluminum cocatalyst is introduced into the second reactor in an amount sufficient to restore the level of activity of the catalyst transferred from the first reactor to about the initial level of activity in the first reactor.

Energy-activated room temperature-pumpable polymer compositions and devices for activating and dispensing the same

Gas-phase polymerization process having multiple flow regimes

THE PRESENT INVENTION RELATES TO AN IMPROVEMENT FOR GAS PHASE OLEFIN POLYMERIZATION PROCESS UNDER TWO OR MORE DIFFERENT FLOW REGIMES. THE PROCESS INVOLVES ADDING A MIXED ELECTRON DONOR SYSTEM TO A REACTOR HAVING TWO OR MORE DIFFERENT FLOW REGIMES, WHEREIN THE MIXED ELECTRON DONOR SYSTEM COMPRISES AT LEAST ONE SELECTIVITY CONTROL AGENT AND AT LEAST ONE ACTIVITY LIMITING AGENT. THE INVENTION IS PARTICULARLY WELL SUITED FOR REACTOR SYSTEMS WHICH INCLUDE A REGIME CHARACTERIZED BY HAVING A LOW-VELOCITY OR HIGH-SOLID HOLDUP, WHICH HAVE BEEN REPORTED TO HAVE OPERATIONAL PROBLEMS SUCH AS PARTICLE AGGLOMERATION AND FORMATION OF POLYMER ?CHUNKS?. (NO SUITABLE

Bispecific molecules with clinical application

sistema de catalisador de hafnoceno-titanoceno

Um sistema de catalisador de hafnoceno-titanoceno compreendendo um catalisador de hafnoceno e um catalisador de titanoceno; poliolefinas; métodos de fazer e usar as mesmas; e artigos contendo as mesmas.

Process to visbreak propylene-based polymers with c-c initiators

The invention provides a process to prepare a second propylene-based polymer from a first propylene-based polymer, each propylene-based polymer having a melt flow rate (MFR; 2.16kg/230°C) with the MFR of the second propylene-based polymer greater than the MFR of the first propylene-based polymer, the process comprising the step of contacting under visbreaking conditions the first propylene-based polymer with at least one carbon-carbon (C-C) free-radical initiator of Structure (I): (Structure (I)) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each, independently, a hydrocarbyl group or a substituted hydrocarbyl group, and wherein, optionally, two or more R groups (R 1 , R 2 , R 3 , R 4 , R 5 and R 6 ) form a ring structure.

Ethylene polymerization using ziegler-natta catalyst compositions

process for gas polymerization of ethylene

PROCESSO PARA A POLIMERIZAÇÃO DE MONÔMEROS OLEFÍNICOS. Processo para a polimerização de monômeros olefínicos compreendendo contatar etileno ou uma mistura de etileno e uma ou mais ?-olefinas de C4-8 com uma composição de catalisador compreendendo compostos procatalisadores Ziegler-Natta contendo um ou mais metais de transição de Grupo 3-10; um ou mais co-catalisadores de alquilalumínio; e um ou mais agentes controladores de polimerização, caracterizado pelo fato de pelo menos um de tais agentes controladores ser um alquil ou aril éster de um ácido (poli)carboxílico alifático ou aromático contendo opcionalmente um ou mais substituintes compreendendo um heteroátomo de Grupo 13, 14, 15 ou 16. PROCESS FOR THE POLYMERIZATION OF OLEPHINE MONOMERS. A process for the polymerization of olefinic monomers comprising contacting ethylene or a mixture of ethylene and one or more C4-8? -Olefins with a catalyst composition comprising Ziegler-Natta procatalizing compounds containing one or more Group 3-10 transition metals; one or more alkyl aluminum co-catalysts; and one or more polymerization controlling agents, characterized in that at least one of such controlling agents is an alkyl or aryl ester of an aliphatic or aromatic (poly) carboxylic acid optionally containing one or more substituents comprising a Group 13 heteroatom , 15 or 16.

Control of resin split in single-reactor manufacture of bimodal polyolefins

zirconocene-titanocene catalyst system

Um sistema de catalisador de zirconoceno-titanoceno compreendendo um catalisador de zirconoceno e um catalisador de titanoceno; poliolefinas; métodos de fazer e usar as mesmas; e artigos contendo as mesmas. A zirconocene-titanocene catalyst system comprising a zirconocene catalyst and a titanocene catalyst; polyolefins; methods of making and using them; and articles containing them.

Hafnocene-titanocene catalyst system

A hafnocene-titanocene catalyst system comprising a hafnocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

Hafnocene-titanocene catalyst system

A hafnocene-titanocene catalyst system comprising a hafnocene catalyst and a titanocene catalyst; polyolefins; methods of making and using same; and articles containing same.

High strength polyethylene film

A blend comprises two ethylene alpha -olefin copolymers. The blend has: (i) a flow index (FI) the range of about 5 to about 50 g \ 10 minutes; (ii) a melt flow ratio (MFR) = 10 to about 50; (iii) density = 0.900 to 0.940 g cm -3; (iv) a weight average molecular weight (MW) = 98,000 to about 190.000; (v) and an Mw/Mn = 2 to about 8. Each copolymer being a copolymer of ethylene and an alpha -olefin of 3C to 8C. The first copolymer has: (i) FI = 5 to about 75 g \ 10 minutes; (ii) MFR 10 to about 50; (iii) a density = 0.860 to 0.930 g cm-3;(iv) a weight average MW = 87,000 to about 190.000; and (v) an Mw/Mn ratio = 2 to about 4 and the second copolymer has (i) FI = 5 to about 75 g \ 10 minutes; (ii) MFR = 10 to about 50; (iii) a density = 0.935 to 0.970 g cm-3; (iv) MW = 87,000 to about 190,000; and (v) Mw/Mn ratio = 2 to about 4, the weight ratio of the first copolymer to the second copolymer = 70:30 to about 30:70. Also claimed is the preparation of the blend.

Control of resin split in single-reactor manufacture of bimodal polyolefins

Bimodal resin products are produced in a single reactor by using two bicomponent catalyst compositions, each having a high molecular weight and a low molecular weight component, in different ratios. The HMW/LMW split of the final resin product is controlled accurately by controlling the ratio of the feed of the two bicomponent catalyst compositions. Bimodal or polymodal effects are also achieved for properties or characteristics other than molecular weight. More complex results can be achieved with more than two components. The invention is applicable to a wide variety of polymer products, particularly polyolefins and polyethylene.

Catalyst composition for ethylene polymerization

The invention relates to a process for polymerizing an olefin monomer comprising: (i) contacting, in a reactor, the olefin monomer consisting of ethylene, with a catalyst composition comprising one or more Group 3-10 transition metal containing Ziegler-Natta procatalyst compounds; and one or more alkylaluminum cocatalysts; (ii) providing to the reactor one or more polymerization control agents, wherein at least one such polymerization control agent is an alkyl or aryl ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom and the polymerization control agents is or are provided at a polymerization control agent to co-catalyst ratio from 1:1 to 1:100 such that the polymerization control agent stops the polymerization reaction at a temperature greater than 100°C.; (iii) gas phase polymerizing at a reactor temperature of greater than 80°C. to form a polymer; and (iv) extracting the polymer from the reactor.

High strength polyethylene film

A blend comprising a mixture of two ethylene/alpha-olefin copolymers, said blend having a flow index in the range of about 5 to about 50 grams per 10 minutes; a melt flow ratio in the range of about 10 to about 50; a density in the range of 0.900 to 0.940 gram per cubic centimeter; a molecular weight in the range of about 98,000 to about 190,000; and an Mw/Mn ratio in the range of about 2 to about 8, said blend having been prepared by mixing first and second copolymers having about equal molecular weights, each copolymer being a copolymer of ethylene and an alpha-olefin having 3 to 8 carbon atoms, the first copolymer having a flow index in the range of about 6 to about 75 grams per 10 minutes; a melt flow ratio in the range of about 10 to about 60; a density in the range of 0.860 to 0.930 gram per cubic centimeter; a molecular weight in the range of about 87,000 to about 190,000; and an Mw/Mn ratio in the range of about 2 to about 4 and the second copolymer having a flow index in the range of about 5 to about 75 grams per 10 minutes; a melt flow ration in the range of about 10 to about 50; a density in the range of 0.935 to 0.970 gram per cubic centimeter; a molecular weight in the range of about 87,000 to about 190,000; and an Mw/Mn ratio in the range of about 2 to about 4, the weight ratio of the first copolymer to the second copolymer being in the range of about 70:30 to about 30:70.

Proceso de polimerizacion de face gaseosa que tienen multiples regimenes de flujo.

La presente invención se refiere a una mejora para el proceso de polimerización de olefinas de fase gaseosa bajo dos o más regímenes de flujo diferentes. El proceso consiste en añadir un sistema mixto de donador de electrones a un reactor que tiene dos o más regímenes de flujo diferentes, en donde el sistema mixto de donador de electrones comprende al menos un agente de control de selectividad y al menos un agente limitante de actividad. La invención es particularmente adecuada para sistemas de reactor los cuales incluyen un régimen caracterizado por tener una alta retención de sólidos o de baja velocidad, la cual ha presentado problemas operativos tales como aglomeración de partículas y formación de "trozos" de polímeros.

Catalyst composition for ethylene polymerization

Catalyst composition for ethylene polymerization

A process for the polymerization of olefin monomers comprising contacting ethylene or a mixture of ethylene and one or more C4-8 α olefins with a catalyst composition comprising one or more Group 3-10 transition metal containing, Ziegler-Natta, procatalyst compounds; one or more alkylaluminum cocatalyts; and one or more polymerization control agents, said process being characterized in that at least one such polymerization control agent is an alkyl or aryl. ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

process for the polymerization of gas ethylene

PROCESSO PARA A POLIMERIZAÇÃO DE MONÔMEROS OLEFÍNICOS". Processo para a polimerização de monômeros olefínicos compreendendo contatar etileno ou uma mistura de etileno e uma ou mais 244>olefinas de C~ 4-8~ com uma composição de catalisador compreendendo compostos procatalisadores Ziegler-Natta contendo um ou mais metais de transição de Grupo 3-10; um ou mais co-catalisadores de alquilalumínio; e um ou mais agentes controladores de polimerização, caracterizado pelo fato de pelo menos um de tais agentes controladores ser um alquil ou aril éster de um ácido (poli)carboxílico alifático ou aromático contendo opcionalmente um ou mais substituintes compreendendo um heteroátomo de Grupo 13, 14, 15, ou 16. PROCESS FOR THE POLYMERIZATION OF OLEFINIC MONOMERS ". Process for the polymerization of olefinic monomers comprising contacting ethylene or a mixture of ethylene and one or more 244> C ~ 4-8 ~ olefins with a catalyst composition comprising Ziegler-Natta procatalyser compounds containing one or more transition metals of Group 3-10; one or more alkyl aluminum co-catalysts; and one or more polymerization controlling agents, characterized in that at least one of such controlling agents is an alkyl or aryl ester of an acid aliphatic or aromatic (poly) carboxylic optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

Catalyst composition for ethylene polymerization

Un procedimiento para la polimerización en fase gas de etileno, que comprende poner en contacto etileno con una composición de catalizador que comprende uno o varios compuestos procatalizadores de Ziegler-Natta que comprenden un metal de transición del Grupo-3-10; uno o varios cocatalizadores alquilaluminio; y uno o varios agentes de control de la polimerización (PCA) de los que al menos uno es un éster de alquilo o un éster de arilo de un ácido (poli)carboxílico ailfático o aromático que opcionalmente contiene uno o varios sustituyentes que comprenden un heteroátomo del Grupo 13, 14, 15 o 16, en el que la temperatura de polimerización es mayor que 80ºC y el PCA está presente en una relación molar de PCA:cocatalizador(es) de 1:1 a 1:100. A process for gas phase polymerization of ethylene, comprising contacting ethylene with a catalyst composition comprising one or more Ziegler-Natta procatalyst compounds comprising a Group-3-10 transition metal; one or more aluminum alkyl cocatalysts; and one or more polymerization control agents (PCAs) of which at least one is an alkyl ester or an aryl ester of an aromatic or aromatic (poly) carboxylic acid optionally containing one or more substituents comprising a heteroatom from Group 13, 14, 15 or 16, in which the polymerization temperature is greater than 80 ° C and the PCA is present in a molar ratio of PCA: cocatalyst (s) of 1: 1 to 1: 100.

Catalyst composition for ethylene polymerization

A PROCESS FOR THE POLYMERIZATION OF OLEFIN MONOMERS COMPRISING CONTACTING ETHYLENE OR A MIXTURE OF ETHYLENE AND ONE OR MORE C4-8 (a)-OLEFINS WITH A CATALYST COMPOSITION COMPRISING ONE OR MORE GROUP 3-10 TRANSITION METAL CONTAINING, ZIEGLER-NATTA, PROCATALYST COMPOUNDS; ONE OR MORE ALKYLALUMINUM COCATALYST; AND ONE OR MORE POLYMERIZATION CONTROL AGENTS, SAID PROCESS BEING CHARACTERIZED IN THAT AT LEAST ONE SUCH POLYMERIZATION CONTROL AGENTS IS AN ALKYL OR ARYL ESTER OF AN ALIPHATIC OR AROMATIC (POLY)CARBOXYLIC ACID OPTIONALLY CONTAINING ONE OR MORE SUBSTITUENTS COMPRISING A GROUP 13, 14, 15, OR 16 HETEROATOM.

Polimerización de polietileno usando composiciones de catalizador de Ziegler-Natta

Un procedimiento para la polimerización en fase gas de etileno, que comprende poner en contacto etileno con una composición de catalizador que comprende uno o varios compuestos procatalizadores de Ziegler-Natta que comprenden un metal de transición del Grupo 3-10; uno o varios cocatalizadores alquilaluminio; y uno o varios agentes de control de la polimerización (PCA) seleccionados de derivados alquil C1-10 monoéter de ésteres de alquilo C1-10 de ácido benzoico, derivados alquil C1-10 monoéter de ésteres de dialquilo C1-10 de ácido ftálico y derivados alquil C1-10 monoéter de ésteres de dialquilo C1-10 de ácido tereftálico, en donde la temperatura de polimerización es mayor que 85 ºC y el PCA está presente a una relación molar PCA:cocatalizador(es) de 1:1 a 1:100.

Catalyst composition for ethylene polymerization

Catalyst composition for ethylene polymerization

A process for the polymerization of olefin monomers comprising contacting ethylene or a mixture of ethylene and one or more C4-8 .alpha. olefins with a catalyst composition comprising one or more Group 3-10 transition metal containing, Ziegler-Natta, procatalyst compounds; one or more alkylaluminum cocatalyts; and one or more polymerization control agents, said process being characterized in that at least one such polymerization control agent is an alkyl or aryl. ester of an aliphatic or aromatic (poly)carboxylic acid optionally containing one or more substituents comprising a Group 13, 14, 15, or 16 heteroatom.

Control of resin split in single-reactor manufacture of bimodal polyolefins

Bimodal resin products are produced in a single reactor by using two bicomponent catalyst compositions, each having a high molecular weight and a low molecular weight component, in different ratios. The HMW/LMW split of the final resin product is controlled accurately by controlling the ratio of the feed of the two bicomponent catalyst compositions. Bimodal or polymodal effects are also achieved for properties or characteristics other than molecular weight. More complex results can be achieved with more than two components. The invention is applicable to a wide variety of polymer products, particularly polyolefins and polyethylene.

Control of resin split in single-reactor manufacture of bimodal polyolefins

Bimodal resin products are produced in a single reactor by using two bicomponent catalyst compositions, each having a high molecular weight and a low molecular weight component, in different ratios. The HMW/LMW split of th e final resin product is controlled accurately by controlling the ratio of the feed of the two bicomponent catalyst compositions. Bimodal or polymodal effects are also achieved for properties or characteristics other than molecular weight. More complex results can be achieved with more than two components. The invention is applicable to a wide variety of polymer product s, particularly polyolefins and polyethylene.

Control of resin split in single-reactor manufacture of bimodal polyolefins

Gas-phase polymerization process having multiple flow regimes

Gas-phase polymerization process having multiple flow regimes

The present invention relates to an improvement for gas phase olefin polymerization process under two or more different flow regimes. The process involves adding a mixed electron donor system to a reactor having two or more different flow regimes, wherein the mixed electron donor system comprises at least one selectivity control agent and at least one activity limiting agent. The invention is particularly well suited for reactor systems which include a regime characterized by having a low-velocity or high-solid holdup, which have been reported to have operational problems such as particle agglomeration and formation of polymer "chunks".

Ethylene-based polymer composition with multifunctional branching agent and process for producing same

The present disclosure provides a process. In an embodiment, the process includes providing a multifunctional branching agent (MFBA). The MFBA has A) three or more carbon- carbon double bonds with the provisos (1) that the MFBA is not a polymer of butadiene, and (2) the MFBA does not contain an acrylate group or a methacrylate group. The MFBA has B) a total reactivity, R, greater than 3 and less than 40, (3<R<40) wherein R is determined with the following formula (I): wherein j = index of summation, p = the number of different types of carbon-carbon double bonds j in the molecule, n j = the number of each carbon-carbon double bond of type j in the molecule, and r 1,j = the relative reactivity ratio (RRR) of ethylene to the carbon-carbon double bond j. The process includes reacting the MFBA with ethylene under polymerization conditions and forming an ethylene-based polymer composition composed of units of ethylene and units of the MFBA. The present disclosure also provides the ethylene-based polymer composition resulting from the process.

High strength polyethylene film

Process to visbreak propylene-based polymers with c-c initiators

Process to visbreak propylene-based polymers with C—C initiators

The invention provides a process to prepare a second propylene-based polymer from a first propylene-based polymer, each propylene-based polymer having a melt flow rate (MFR; 2.16 kg/230° C.) with the MFR of the second propylene-based polymer greater than the MFR of the first propylene-based polymer, the process comprising the step of contacting under visbreaking conditions the first propylene-based polymer with at least one carbon-carbon (C—C) free-radical initiator of Structure (I): (Structure (I)) wherein R1, R2, R3, R4, R5 and R6 are each, independently, a hydrocarbyl group or a substituted hydrocarbyl group, and wherein, optionally, two or more R groups (R1, R2, R3, R4, R5 and R6) form a ring structure.

High strength polyethylene film

(57)【要約】 （修正有） 【課題】 ポリエチレン共重合体のブレンドから押し出 された高強度ポリエチレンフィルムを提供する。 【解決手段】 ２種のエチレン／α−オレフィン共重合 体の混合物からなるブレンドであって、 ・該ブレンドが約５〜５０ｇ／１０分間の範囲のフロー インデックス、約１０〜５０の範囲のメルトフロー比、 ０．９００〜０．９４０ｇ／ｃｍ 3 の密度、約９８，０ ００〜１９０，０００の範囲の分子量及び約２〜８の範 囲のＭｗ／Ｍｎ比を有し、 ・該ブレンドがほぼ等しい分子量を有する第一共重合体 と第二共重合体を混合することによって製造されたもの であり、 ・各共重合体はエチレンと３〜８個の炭素原子を有する α−オレフィンとの共重合体で、上記特性値が所定範囲 のものを使う。

Method and apparatus for identifying, classifying, or quantifying dna sequences in a sample without sequencing

This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Several alternative embodiments are described which are capable of increased discrimination and which use TypeIIS restriction endonucleases, various capture moieties, or samples of specially synthesized cDNA. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information.

Active agent combination, useful e.g. as an active substance against bacteria, fungus and virus and as deodorant or antiperspirant, comprises epsilon-polylysine and aromatic esters with terpene structure

Active agent combination comprises epsilon -polylysine and one or more aromatic esters with terpene structure. ACTIVITY : Antibacterial; Fungicide; Virucide. MECHANISM OF ACTION : None given.

Soy polysaccharide ethers

Soy polysaccharide ether compounds are disclosed herein comprising uncharged, anionic, and/or cationic organic groups. The degree of substitution of one or more ether compounds is about 0.0025 to about 3.0. Also disclosed are methods of producing these soy polysaccharide ether compounds, as well as methods of their use for increasing the viscosity of aqueous compositions. Compositions comprising ether compounds are also disclosed.

Microprocessor with integrated CPU, RAM, timer, bus arbiter data for communication system

A microprocessor device used as an adapter for a communications loop of the closed-ring, token-passing, local area network type. Each station on the ring has a host processor with a host CPU, a main memory, and a system bus. The microprocessor device, operating relatively independent of the host CPU, is coupled to the main memory by the system bus and includes a local CPU, a local read/write memory, an on-chip timer, a local bus and a bus arbiter. A transmit/receive controller is connected between the ring and the microprocessor device. This controller is coupled to the local bus to directly access the local read/write memory, also under control of the bus arbiter. The local CPU executes instructions fetched from a ROM accessed by the local bus, so the local CPU instruction fetch, the direct memory access from the transmit/receive controller for transmitting or receiving data frames, and the access from the host CPU for copying transmitted or received message frames, all contend for the local bus. Bus arbitration with appropriate priorities is used to control access to the local bus. The on-chip timer accessed by the local bus provides the time period used to monitor and control the communications protocol.

Two-piece funnel with long, ribbed spout

Anti-IL-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Sequestration of carbon dioxide with hydrogen to useful products

Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydoxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4- hydoxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.

Solid supports for nucleic acid hybridization assays

Compositions and methods for covalently immobilizing an oligonucleotide onto a polymer-coated solid support or similar structure are provided. Specifically, the polymer-coated support, such as a bead, possesses a large number of activatable moieties, preferably primary and secondary amines. An oligonucleotide is activated with a monofunctional or multifunctional reagent, preferably the homotrifunctional reagent cyanuric chloride. The resultant covalently immobilized oligonucleotides on the support serve as nucleic acid probes, and hybridization assays can be conducted wherein specific target nucleic acids are detected in complex biological samples. The beads or similar structures can be employed free in solution, such as in a microtiter well format; in a flow-through format, such as in a column; or in a dipstick. Additionally, dichlorotriazine oligonucleotides and processes for activating oligonucleotides by treatment with cyanuric chloride and derivatives are included in the present invention.

Peptide linkers for improved oligonucleotide delivery

A covalently linked conjugate of an oligonucleotide (ODN) with a peptide and a carrier or targeting ligand (ODN-peptide-carrier) includes a therapeutic oligonucleotide which is capable of selectively binding to a target sequence of DNA, RNA or protein inside a target cell. The ODN is covalently linked to a peptide which is capable of being cleaved by proteolytic enzymes inside the target cell. The peptide, in turn is covalently linked to a carrier or targeting ligand moiety which facilitates delivery of the entire ODN-peptide-carrier conjugate into the cell, and preferably into a specific target tissue type. Inside the cell, the peptide is cleaved, releasing the ODN which, by binding to the target DNA, RNA or protein sequence, brings about a beneficial result.

Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids

Mutant delta 5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b 5 -like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta 5 desaturases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"], are also disclosed.

MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES

Mutant acyl-CoA:lysophosphatidylcholine acyltransferases ["LPCATs"] having the ability to convert acyl-CoA + 1-acyl- sn -glycero-3-phosphocholine to CoA + 1,2-diacyl- sn -glycero-3-phosphocholine (EC 2.3.1.23) are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant LPCATs, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"] using these mutant LPCATs in oleaginous yeast, are also disclosed.

Bispecific reagents for AIDS treatment

Anti-il-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibody nucleic acid molecules and methods

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Methods of treating conditions using anti-IL-6 antibodies

Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

Anti-IL-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Pen-injector device containing anti-IL-6 antibodies

A pen-injector device comprising an anti-IL-6 antibody with a liquid formulation have applications in diagnostic and/or therapeutic compositions, methods and devices.

Methods of suppressing rheumatoid arthritis using an anti-IL-6 antibody

Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

Anti-il-6 antibodies, compositions, methods and uses

Anti-IL-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

ISOLATED IL-6 ANTIBODY, ISOLATED NUCLEIC ACID MOLECULE AND VECTOR, TRANSGENIC MICRO-ORGANISM HOST CELL, METHOD FOR PRODUCING AN IL-6 ANTIBODY, COMPOSITION INCLUDING ISOLATED IL-6 ANTIBODY, AND AN IL-6 ANTIBODY COMPRISING A MEDICAL DEVICE FOR PHARMACEUTICAL OR HUMAN DIAGNOSTIC USE

anticorpo il-6 isolado, anticorpo humano isolado projetado, anticorpo humano isolado ou humano projetado, molécula e vetor de ácido nucléico isolado, método para a produção de um anticorpo il-6, composição compreendendo o anticorpo il-6 isolado, anticorpo ou fragmento antiidiótipo, uso do referido anticorpo, dispositivo médico que compreende um anticorpo il-6 e artigo fabricado para uso farmacêutico ou diagnóstico humano. a presente invenção se refere a um anticorpo anti-il-6, incluindo ácidos nucléicos isolados que codificam pelo menos um anticorpo anti-il-6, vetores, células hospedeiras, animais ou plantas transgênicas e métodos de fabricação e utilização destes têm aplicações em composições, métodos e dispositivos diagnósticos e/ou terapêuticos. isolated IL-6 antibody, isolated designed human antibody, isolated human or designed human antibody, isolated nucleic acid molecule and vector, method for producing an IL-6 antibody, composition comprising the isolated IL-6 antibody, antibody or anti-idiotype fragment , use of said antibody, medical device comprising a IL-6 antibody, and article of manufacture for human pharmaceutical or diagnostic use. the present invention relates to an anti-il-6 antibody, including isolated nucleic acids encoding at least one anti-il-6 antibody, vectors, host cells, transgenic animals or plants and methods of making and using these have applications in compositions , diagnostic and/or therapeutic methods and devices.

Anti-il-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies, compounds methods and uses

Un anticuerpo IL-6 aislado que incluye: (i) Una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: 101 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 103; (ii) Una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: 124 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 126; (iii) Una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: l16 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 118; (iv) Una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: 120 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 122; (v) Una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: 128 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 130; o (vi) una secuencia de aminoácido de región variable de cadena ligera con Nº DE ID DE SEC: 97 y una secuencia de aminoácido de región variable de cadena pesada con Nº DE ID DE SEC: 99. An isolated IL-6 antibody that includes: (i) A light chain variable region amino acid sequence with SEQ ID NO: 101 and a heavy chain variable region amino acid sequence with SEQ ID NO: 103; (ii) A light chain variable region amino acid sequence with SEQ ID NO: 124 and a heavy chain variable region amino acid sequence with SEQ ID NO: 126; (iii) A light chain variable region amino acid sequence with SEQ ID NO: 11 and a heavy chain variable region amino acid sequence with SEQ ID NO: 118; (iv) A light chain variable region amino acid sequence with SEQ ID NO: 120 and a heavy chain variable region amino acid sequence with SEQ ID NO: 122; (v) A light chain variable region amino acid sequence with SEQ ID NO: 128 and a heavy chain variable region amino acid sequence with SEQ ID NO: 130; or (vi) a light chain variable region amino acid ...

Anti-il-6 antibodies, compositions, methods and uses

Humanized anti-IL-6 antibodies, compositions, methods and uses

Anti-il-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-il-6 antibodies, compositions, methods and uses

Anti-il-6 antibodies, compositions, methods and uses

Izolovano anti-IL-6 antitelo koje sadrži: (i) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu Identifikacionim brojem sekvence (SEQ ID NO): 101 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 103; (ii) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu kao SEQ ID NO: 124 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 126; (iii) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu kao SEQ ID NO: 116 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 118; (iv) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu kao SEQ ID NO: 120 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 122; (v) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu kao SEQ ID NO: 128 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 130; ili (vi) aminokiselinsku sekvencu varijabilnog regiona lakog lanca označenu kao SEQ ID NO: 97 i aminokiselinsku sekvencu varijabilnog regiona teškog lanca označenu kao SEQ ID NO: 99. Prijava sadrži još 20 patentnih zahteva. Isolated anti-IL-6 antibody comprising: (i) the amino acid sequence of the light chain variable region labeled Sequence Identification Number (SEQ ID NO): 101 and the amino acid sequence of the heavy chain variable region designated SEQ ID NO: 103; (ii) the amino acid sequence of the light chain variable region designated SEQ ID NO: 124 and the amino acid sequence of the heavy chain variable region designated SEQ ID NO: 126; (iii) the amino acid sequence of the light chain variable region designated SEQ ID NO: 116 and the amino acid sequence of the heavy chain variable region designated SEQ ID NO: 118; (iv) the amino acid sequence of the light chain variable region designated SEQ ID NO: 120 and the amino acid sequence of the heavy chain variable region designated SEQ ID NO: 122; (v) the ...

Anti-il-6 antibodies, compositions, methods and uses

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Humanized anti-IL-6 antibodies, compositions, methods and uses

Humanized anti-IL-6 antibodies, compositions, methods and uses

Humanized anti-IL-6 antibodies, compositions, methods and uses

Un anticuerpo anti IL-6 aislado, con regiones marco y constantes completamente humanas, que comprende: (i) una región variable de cadena ligera, que comprende una secuencia de aminoácidos de la cadena ligera de la región determinante de la complementariedad 1 (CDRL1) de la SEC ID Nº:3, una secuencia de aminoácidos de la CDRL2 de la SEC ID Nº:21, una secuencia de aminoácidos de la CDRL3 de la SEC ID Nº:29, y una región variable de la cadena pesada, que comprende una secuencia de aminoácidos de la cadena pesada de la región determinante de la complementariedad 1 (CDRH1) de la SEC ID Nº:39, una secuencia de aminoácidos de la CDRH2 de la SEC ID Nº:59, y una secuencia de aminoácidos de la CDRH3 de la SEC ID Nº:89; o (ii) una región variable de cadena ligera, en la que la CDRL1 comprende la secuencia de aminoácidos de la de la SEC ID Nº:3, la CDRL2 comprende la secuencia de aminoácidos de la de la SEC ID Nº:21, la CDRL3 comprende la secuencia de aminoácidos de la SEC ID Nº:29, y una región variable de la cadena pesada en la que la CDRH1 comprende la secuencia de aminoácidos de la SEC ID Nº:41, la CDRH2 comprende la secuencia de aminoácidos de la SEC ID Nº:75, y la CDRH3 comprende la secuencia de aminoácidos de la SEC ID Nº:89; o iii) una región variable de cadena ligera, en la que la CDRL1 comprende la secuencia de aminoácidos de la de la SEC ID Nº:15, la CDRL2 comprende la secuencia de aminoácidos de la de la SEC ID Nº:27, la CDRL3 comprende la secuencia de aminoácidos de la SEC ID Nº:35, y una región variable de la cadena pesada en la que la CDRH1 comprende la secuencia de aminoácidos de la SEC ID Nº:47, la CDRH2 comprende la secuencia de aminoácidos de la SEC ID Nº:57, y la CDRH3 comprende la secuencia de aminoácidos de la SEC ID Nº:91; o iv) una región variable de cadena ligera, en la que la CDRL1 comprende la secuencia de aminoácidos de la de la SEC ID Nº:15, la CDRL2 comprende la secuencia de aminoácidos de la de la SEC ID Nº:17, la CDRL3 comprende la secuencia de ...

Humanized anti-il-6 antibodies, compositions, methods and uses