Method for preparing 2-(N-substituted)-amino-benzimidazole derivatives

A method for preparing 2-(N-substituted)-amino-benzimidazole derivatives is provided, which comprises the following steps: (1) reacting a compound of 2-(N-protecting group)-O-aryl diamine with a compound of N-phenoxycarbonyl monosubstituted amine to obtain a compound of 2-(N-protecting group)-amino aryl urea; (2) in a suitable organic solvent, performing dehydrating cyclization reaction of the compound of 2-(N-protecting group)-amino aryl urea in the presence of an organic base and dichloro triphenylphosphine prepared by triphenylphosphine oxide with oxalyl chloride or diphosgene or triphosgene, or dibromo triphenylphosphine prepared by triphenylphosphine oxide with bromine, to produce a compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole; (3) deprotecting the resulting compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole to obtain the compound 2-(N-substituted)-amino-benzimidazole.

Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture

The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (PNIPAM)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.

Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture

The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (PNIPAM)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.

Synthesis, uses and compositions of crystal hydrogels

A method is disclosed for creating hydrogels with ordered crystalline structures that exhibit a characteristic colored opalescence. In addition to the unique optical properties, these materials contain a large amount of water in their crosslinked networks. The manufacturing processes include synthesizing monodispersed hydrogel nanoparticles containing specific reactive functional groups, self-assembly of these particles to form a crystalline structure, and subsequent crosslinking neighboring spheres to stabilize the entire network. Polymerizing a hydrogel monomeric composition around the crystalline structure can enhance the mechanical strength. The resulting network is dimensionally and thermodynamically stabile under various pH and temperature conditions. The color and volume of these crystalline hydrogel networks can reversibly change in response to external stimuli such as temperature, pH and other environmental conditions. These new materials may lead to a variety of technological ...

Preparation method of high-optical purity N2-[1 -(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine

Disclosed is a preparation method of high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine. The method includes: adding crude N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine to one or more organic solvents, and then reacting with an organic acid to form a salt, which is precipitated, thereby achieving the purpose of separation and purification; next, adding the obtained solid or mother concentrate into deionized water, and then adding an inorganic base or an organic base for basification, so as to adjust the pH value, removing the organic acid, filtering, washing and drying, to obtain the high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine, where the molar ratio of 1S-isomer to 1R-isomer is equal to or greater than 99:1.

MONODISPERSE THERMO-RESPONSIVE MICROGELS OF POLY(ETHYLENE GLYCOL) ANALOGUE-BASED BIOPOLYMERS, THEIR MANUFACTURE, AND THEIR APPLICATIONS

Composition, processes, techniques, and apparatus for synthesizing monodisperse microgels based on poly(ethylene glycol) (PEG) derivative polymers by using precipitation polymerization. These microgels are hydrophilic and have the adjustable volume phase transition temperature in aqueous environment. Microgels can be added with various functional groups. These microgels in water can self-assemble into various phases, including a crystalline phase. Hydrogel films with iridescent colors were formed using these microgels as crosslinkers to connect poly(ethylene glycol) chains. The colors of these hydrogel films change with changes of environment such temperature, pH, salt concentration, etc.

PREPARATION METHOD OF HIGH-OPTICAL PURITY N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6-TRIFLUOROACETYL-L-LYSINE

Disclosed is a preparation method of high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine. The method includes: adding crude N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine to one or more organic solvents, and then reacting with an organic acid to form a salt, which is precipitated, thereby achieving the purpose of separation and purification; next, adding the obtained solid or mother concentrate into deionized water, and then adding an inorganic base or an organic base for basification, so as to adjust the pH value, removing the organic acid, filtering, washing and drying, to obtain the high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine, where the molar ratio of 1S-isomer to 1R-isomer is equal to or greater than 99:1.

2-substituted-2H-1, 2, 3-triazole derivative and its preparation method

Disclosed is a 2-substituted-2H-1,2,3-triazole derivative, a compound as represented by formula I or II. Also disclosed is a preparation method of the compound as represented by formula I or II, in particular to a preparation method of 2-substituted-4-bromo-5-chloro-1H-1,2,3-triazole, 2-substituted-4-bromo-5-iodo-1H-1,2,3-triazole, and 2-substituted-5-chloro-1H-1,2,3-triazole-4-carboxylic acid. The preparation methods of the present invention are simple and feasible, and has high yield of the obtained compounds.

Synthesis, uses and compositions of crystal hydrogels

A method is disclosed for creating hydrogels with ordered crystalline structures that exhibit a characteristic colored opalescence. In addition to the unique optical properties, these materials contain a large amount of water in their crosslinked networks. The manufacturing processes include synthesizing monodispersed hydrogel nanoparticles containing specific reactive functional groups, self-assembly of these particles to form a crystalline structure, and subsequent crosslinking neighboring spheres to stabilize the entire network. Polymerizing a hydrogel monomeric composition around the crystalline structure can enhance the mechanical strength. The resulting network is dimensionally and thermodynamically stabile under various pH and temperature conditions. The color and volume of these crystalline hydrogel networks can reversibly change in response to external stimuli such as temperature, pH and other environmental conditions. These new materials may lead to a variety of technological ...

Method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation

Provided is a method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation. The methoduses 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with air as an oxidizing agent, to obtain 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The method employs a mild, safe and clean reaction, and is suitable for industrial mass production.

TUNABLE POLYMER-BASED SONIC STRUCTURES

Tunable polymer-based sonic structures (“TuPSS”) are made up of sonic structures and polymers. The TuPSS has three general requirements: a) The sonic structure is composed of one or materials engineered to behave as a lens, filter, cloak, or dampener; b) Stimulus sensitive polymer is incorporated into the sonic structure; and c) The actuation of the polymer tunes the acoustic behavior of the structure in a predictable manner. The tunable polymer-based sonic structures utilize stimuli-driven physical properties of the polymers in these acoustic structures to produce a stimulus driven, or tunable, sonic structure or device. The sonic structures actively modulate mechanical vibrations that propagate through the structures, but are passive in that they do not produce mechanical vibrations. The stimuli for the structures include electric, magnetic, electromagnetic, chemical, thermal, and shaking/orientation.

Tunable polymer-based sonic structures

Tunable polymer-based sonic structures (TuPSS) are made up of sonic structures and polymers. The TuPSS has three general requirements: a) The sonic structure is composed of one or materials engineered to behave as a lens, filter, cloak, or dampener; b) Stimulus sensitive polymer is incorporated into the sonic structure; and c) The actuation of the polymer tunes the acoustic behavior of the structure in a predictable manner. The tunable polymer-based sonic structures utilize stimuli-driven physical properties of the polymers in these acoustic structures to produce a stimulus driven, or tunable, sonic structure or device. The sonic structures actively modulate mechanical vibrations that propagate through the structures, but are passive in that they do not produce mechanical vibrations. The stimuli for the structures include electric, magnetic, electromagnetic, chemical, thermal, and shaking/orientation.

Preparation method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid

Provided is a preparation method for 1-substituted-1H-1, 2, 3-triazole-4-carboxylic acid. 1-Substituted-4, 5-dibromo-1H-1,2,3-triazole is added to an isopropylmagnesium chloride to obtain 1-substituted-4-bromo-1H-1,2,3-triazole by a reaction; then an isopropylmagnesium chloride-lithium chloride composite is added directly to obtain a mixture of 1-substituted-1H-1,2,3-triazole-4-carboxylic acid and 1-substituted-4-bromo-1H-1,2,3-triazole-5-carboxylic acid; secondly, to the mixture, a base and iodomethane are added to obtain 1-substituted-4-bromo-1H-1,2,3-triazole-5-carboxylic acid methyl ester by a reaction; the aqueous layer is adjusted with hydrochloric acid to pH=1-5, extracted with an organic solvent and dried; then 1-substituted-1H-1,2,3-triazole-4-carboxylic acid is obtained by concentration and crystallization. The method is suitable for industrialized production and has a greater application value.

2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD

Disclosed is a 2-substituted-2H-1,2,3-triazole derivative, a compound as represented by formula I or II. Also disclosed is a preparation method of the compound as represented by formula I or II, in particular to a preparation method of 2-substituted-4-bromo-5-chloro-1H-1,2,3-triazole, 2-substituted-4-bromo-5-iodo-1H-1,2,3-triazole, and 2-substituted-5-chloro-1H-1,2,3-triazole-4-carboxylic acid. The preparation methods of the present invention are simple and feasible, and has high yield of the obtained compounds.

Photoresponsive Hydrogels

Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.

method for preparing 2-(N-substituted)-amino-benzimidazole derivatives

A method for preparing 2-(N-substituted)-amino-benzimidazole derivatives is provided, which comprises the following steps: (1) reacting a compound of 2-(N-protecting group)-O-aryl diamine with a compound of N-phenoxycarbonyl monosubstituted amine to obtain a compound of 2-(N-protecting group)-amino aryl urea; (2) in a suitable organic solvent, performing dehydrating cyclization reaction of the compound of 2-(N-protecting group)-amino aryl urea in the presence of an organic base and dichloro triphenylphosphine prepared by triphenylphosphine oxide with oxalyl chloride or diphosgene or triphosgene, or dibromo triphenylphosphine prepared by triphenylphosphine oxide with bromine, to produce a compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole; (3) deprotecting the resulting compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole to obtain the compound 2-(N-substituted)-amino-benzimidazole.

Preparation Method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid

Provided is a preparation method for 1-substituted-1H-1, 2, 3-triazole-4-carboxylic acid. 1-Substituted-4, 5-dibromo-1H-1,2,3-triazole is added to an isopropylmagnesium chloride to obtain 1-substituted-4-bromo-1H-1,2,3-triazole by a reaction; then an isopropylmagnesium chloride-lithium chloride composite is added directly to obtain a mixture of 1-substituted-1H-1,2,3-triazole-4-carboxylic acid and 1-substituted-4-bromo-1H-1,2,3-triazole-5-carboxylic acid; secondly, to the mixture, a base and iodomethane are added to obtain 1-substituted-4-bromo-1H-1,2,3-triazole-5-carboxylic acid methyl ester by a reaction; the aqueous layer is adjusted with hydrochloric acid to pH=1-5, extracted with an organic solvent and dried; then 1-substituted-1H-1,2,3-triazole-4-carboxylic acid is obtained by concentration and crystallization. The method is suitable for industrialized production and has a greater application value.

A method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation

Provided is a method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation. The methoduses 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with air as an oxidizing agent, to obtain 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The method employs a mild, safe and clean reaction, and is suitable for industrial mass production.

Photoresponsive hydrogels

Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.

Non-woven protective clothing against blood and viruses

A non-woven protective clothing against blood and viruses, which is composed from: a non-woven fabric layer, which has two surfaces; and a high waterproof moisture-permeable layer, which is a porous film that is laminated to one of the surfaces of the non-woven fabric layer; and an elastic pore filling layer, which is a hydrophilic polyurethane. The elastic pore filling layer is coated or printed onto the surface of the high waterproof moisture-permeable layer, and the thickness of the elastic pore filling layer is thinner than that of the high waterproof moisture-permeable layer. The synthetic blood permeability of the non-woven protective clothing against blood and viruses can resist a pressure of 2.0 psi for one minute, and the Phi-X174 bacteriophage penetrability thereof can resist a pressure of 2.0 psi for one minute.

N-(2-chloromethyl-1-methyl-1h-benzimidazole-5-acyl)-n-(pyridine-2-yl)-3-aminopropanoic acid ethyl ester preparation method

Pressure control device and grinding device and concentric wire drawing machine using the same

Waterproof, moisture-permeable composite non-woven fabric able to block viruses and blood

The present invention provides a waterproof, moisture-permeable composite non-woven fabric able to block viruses and blood, and consists of a non-woven fabric, which is provided with two surfaces and has a basic weight of ≤70 g/m 2 ; and a multi-layer breathable membrane, which is at least a three-layer co-extruded membrane. The basic weight of the multi-layer breathable membrane lies between 5˜30 g/m 2 and is attached to one of the surfaces of the non-woven fabric. A powder in the multi-layer breathable membrane has a percentage by weight of 40˜60% and an extension ratio ≤300%. The present invention has characteristics including a synthetic blood permeability able to resist pressure of 2.0 psi sustainable for at least one minute, a Phi-X17 bacteriophage penetrability able to resist pressure of 2.0 psi sustainable for at least one minute, and a moisture capacity ≥1500 g/m 2 ·24 hr.

Copper or palladium-copper wire package process and structure thereof

Method for recycling chiral 1-benzyl-3-hydroxypiperidine by racemization

Method for recycling chiral 1-benzyl-3-hydroxypiperidine by racemization

Improved structure for water flange

Non-woven protective clothing against blood and viruses

A non-woven protective clothing against blood and viruses is composed from a non-woven fabric layer, which has two surfaces; and a moisture-permeable layer, which is a porous film that is laminated to one of the surfaces of the non-woven fabric layer; and an elastic pore filling layer, which is a hydrophilic polyurethane. The elastic pore filling layer is coated or printed onto the surface of the moisture-permeable layer, and the thickness of the elastic pore filling layer is thinner than that of the moisture-permeable layer. The synthetic blood permeability of the non-woven protective clothing against blood and viruses can resist a pressure of 2.0 psi for one minute, and the Phi-X174 bacteriophage penetrability thereof can resist a pressure of 2.0 psi for one minute.

Adhesive binder and method for making same

一种基于超构表面的任意波形产生器

基于超构表面的任意波形产生器，包括：表面单元为变形H形结构，变形H形结构指H的两竖成为两个圆弧形，变形H形的单元为具有上下两个缺口即开口的圆形；单元中变形H形结构中：变形H形结构的横与y轴夹角β从0°‑45°变化，单元开口大小：单元中央为角心，H形的横与开口处形成的角度α从87°变化到37°时；包含两个金属层和一个介质层，底层为全金属结构，上层表面单元为变形“H”贴片即变形H形结构，介质层采用介电常数为2.65且厚度为3mm的聚四氟乙烯玻璃布板。

Modified structure of a service shelf

燒刻板之結構