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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 55. Отображено 55.
03-04-2007 дата публикации

Chimeric interleukin-6 soluble receptor/ligand proteins

Номер: US0007198781B1

Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.

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05-03-2002 дата публикации

Chimeric mammals with human hematopoietic cells

Номер: US0006353150B1

There is disclosed a chimeric mammal having a stable bone marrow graft of human hematopoietic cells capable of differentiating into multiple lineages of human mature cells, wherein at least 30% of the hematopoietic cells in the mammal's bone marrow are of human origin. The inventive method comprises sublethally irradiating an immunodeficient mammal, infusing human hematopoietic cells into the mammal and administering an effective amount of human mast cell growth factor (MGF) and a human granulocyte macrophage colony stimulating factor/interleukin-3 fusion protein (GM-CSF/IL-3 FP) to promote engraftment of human cells within the chimeric mammal's bone marrow.

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23-02-2012 дата публикации

SHORT BETA-DEFENSIN-DERIVED PEPTIDES

Номер: US20120045411A1
Принадлежит: Yeda Research and Development Co., Ltd.

The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. 1. A cyclized peptide selected from the group consisting of:(a) 1,10-cyclo[RGRKCCRRKK], (cTL-1, SEQ ID NO: 3), wherein arginine at position 1 is linked through a peptide bond to the lysine at position 10; and(b) a cyclized homolog of SEQ ID NO: 3 having at least 70% sequence homology to SEQ ID NO: 3 and at least 70% identity with regard to the overall positive charge density of SEQ ID NO: 3, wherein the N-terminus and the C-terminus of the peptide are linked through a covalent bond, and wherein the two adjacent cysteines at positions 5 and 6 of SEQ ID NO: 3 are retained.2. The peptide of claim 1 , wherein the homolog has at least 70% of the hydrophilicity/hydrophobicity characteristics of SEQ ID NO: 3.3. A pharmaceutical composition containing an effective amount of the peptide of claim 1 , and one or more pharmaceutically accepted carriers claim 1 , excipients or diluents.4. A pharmaceutical composition containing an effective amount of an isolated peptide having an N-terminus and a C-terminus selected from the group consisting of:(a) RGRKCCRRKK (TL-1, SEQ ID NO: 1);(b) SGRKCCRKKK (AK-1, SEQ ID NO: 2); and(c) a homolog of TL-1, having at least 70% sequence homology to SEQ ID NO: 1, at least 70% identity with regard to the overall positive charge density of SEQ ID NO: 1, wherein the cysteines at positions 5 and 6 of SEQ ID NO: 1 are retained, and wherein said homolog induces or enhances mobilization of hematopoietic progenitor and/or stem cells;and one or more pharmaceutically accepted carriers, excipients or diluents, said composition further comprising at ...

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04-10-2011 дата публикации

Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same

Номер: US0008029780B2

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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30-07-2009 дата публикации

Catecholamine Receptor Modulation

Номер: US20090191162A1
Принадлежит: Yeda Research And Development Co., Ltd.

The invention relates to receptors of catecholamines and their role in stem cell development and function.

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20-05-2008 дата публикации

Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof

Номер: US0007374912B2

Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.

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17-09-2009 дата публикации

Elastase inhibitor and acute leukemia

Номер: US20090232793A1

The invention relates to the use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia, preferably acute leukemia and more preferably for the treatment of AML ...

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28-08-2012 дата публикации

Stem cells having increased sensitivity to SDF-1 and methods of generating and using same

Номер: US0008252588B2

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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14-08-2008 дата публикации

MIGRATION OF HEMATOPOIETIC STEM CELLS AND PROGENITOR CELLS TO THE LIVER

Номер: US20080193426A1
Автор: Orit KOLLET, Tsvee Lapidot
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.

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14-02-2017 дата публикации

Short beta-defensin-derived peptides

Номер: US0009567371B2

The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.

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26-07-2007 дата публикации

Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same

Номер: US20070172464A1
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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26-07-2007 дата публикации

Chimeric Interleukin-6 Soluble Receptor/Ligand Protein, Analogs Thereof and Uses Thereof

Номер: US20070172455A1
Принадлежит: Yeda Research and Development Co., Ltd.

Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.

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31-01-2008 дата публикации

Stem Cells Suitable for Transplantation, their Preparation and Pharmaceutical Compositions Comprising Them

Номер: US20080025957A1
Автор: Tsvee Lapidot, Joy Kahn

The present invention relates to stem cells suitable for transplantation and to methods for their preparation.

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04-01-2007 дата публикации

Stem cells having increased sensitivity to sdf-1 and methods of generating and using same

Номер: US20070003540A1
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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05-09-2006 дата публикации

Hematopoietic cell composition for use in transplantation

Номер: US0007101708B1

Cell compositions consisting essentially of mammalian hematopoietic CXCR4+ stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4-/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. The composition consists preferably of human CD38-/low CXCR44 cells.

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11-12-2008 дата публикации

Use of Protease or a Protease Inhibitor for the Manufacture of Medicaments

Номер: US20080305097A1
Автор: Tsvee Lapidot, Orit Kollet
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

The invention relates to the use of a cathepsin K inhibitor (CTKI) or CTK, a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative, a salt or inducer thereof in the manufacture of a medicament for treating a disease in which SDF-1 activity and/or concentration is involved with the development and/or course of the disease.

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03-11-2011 дата публикации

Stem Cells Suitable for Transplantation, Their Preparation and Pharmaceutical Compositions Comprising Them

Номер: US20110268712A1
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

The present invention relates to stem cells suitable for transplantation and to methods for their preparation.

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13-10-2015 дата публикации

Short beta-defensin-derived peptides

Номер: US0009155780B2

The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells.

Подробнее
09-11-2006 дата публикации

Migration of hematopoietic stem cells and progenitor cells to the liver

Номер: US20060251616A1
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.

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05-02-2013 дата публикации

Stem cells suitable for transplantation, their preparation and pharmaceutical compositions comprising them

Номер: US0008367057B2

The present invention relates to stem cells suitable for transplantation and to methods for their preparation.

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05-05-2016 дата публикации

SHORT BETA-DEFENSIN-DERIVED PEPTIDES

Номер: US20160122391A1
Принадлежит: Yeda Research and Development Co. Ltd.

The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer. 1. A cyclized peptide selected from the group consisting of:(a) 1,10-cyclo[RGRKCCRRKK], (cTL-1, SEQ ID NO: 3), wherein the arginine at position 1 is linked through a peptide bond to the lysine at position 10; and(b) a cyclized homolog of SEQ ID NO: 3 having at least 70% sequence homology to SEQ ID NO: 3 and at least 70% identity with regard to the overall positive charge density of SEQ ID NO: 3, wherein the N-terminus and the C-terminus of the peptide are linked through a covalent bond, and wherein the two adjacent cysteines at positions 5 and 6 of SEQ ID NO: 3 are retained.2. The peptide of claim 1 , wherein the homolog has at least 70% of the hydrophilicity/hydrophobicity characteristics of SEQ ID NO: 3.3. The peptide of claim 1 , wherein the peptide is cTL-1 (SEQ ID NO: 3).4. A pharmaceutical composition containing an effective amount of the peptide of claim 1 , and one or more pharmaceutically accepted carriers claim 1 , excipients or diluents.5. A method for reducing or inhibiting cancer metastasis in a subject in need thereof claim 1 , comprising administering to the subject an effective amount of a peptide as set forth in .6. The method of claim 5 , wherein the subject is afflicted with a tumor characterized by CXCR5 expression of at least a portion of the tumor cells.7. The method of claim 6 , wherein the tumor is of hematopoietic origin.8. The method of claim 6 , wherein the tumor is leukemia.9. The method of claim 5 , wherein the homolog has at least 70% of the hydrophilicity/hydrophobicity characteristics of SEQ ID NO: 3.10. ...

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04-05-2017 дата публикации

Short beta-defensin-derived peptides

Номер: US20170119847A1
Принадлежит: Yeda Research and Development Co Ltd

The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.

Подробнее
27-12-2007 дата публикации

Catecholamine receptor modulation

Номер: CA2655807A1

The invention relates to receptors of catecholamines and their role in stem cell development and function.

Подробнее
05-02-2013 дата публикации

Stem cells having increased sensitivity to sdf-1 and methods of generating and using same

Номер: CA2520023C
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Yeda Research and Development Co Ltd

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

Подробнее
26-05-2009 дата публикации

Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof

Номер: CA2295936C
Принадлежит: Yeda Research and Development Co Ltd

Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.

Подробнее
14-12-1994 дата публикации

Chimeric mammals with human hematopoietic cells.

Номер: EP0625907A4
Принадлежит: Immunex Corp

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31-08-2006 дата публикации

The use of a protease or a protease inhibitor for the manufacture of medicaments

Номер: WO2006048862A3
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Orit Kollet, Tsvee Lapidot, Yeda Res & Dev

The invention relates the use of a cathepsin K inhibitor (CTKI) or CTK, a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative, a salt or inducer thereof in the manufacture of a medicament for treating a disease in which SDF-1 activity and/or concentration is involved with the development and/or course of the disease.

Подробнее
21-10-2004 дата публикации

Stem cells having increased sensitivity to sdf-1 and methods of generating and using same

Номер: CA2520023A1
Автор: Orit Kollet, Tsvee Lapidot

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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30-11-1994 дата публикации

Chimeric mammals with human hematopoietic cells

Номер: EP0625907A1
Принадлежит: Immunex Corp

L'invention concerne un mammifère chimérique ayant une greffe de moelle osseuse stable de cellules hématopoïétiques humaines capables d'effectuer une différentiation dans des lignées multiples de cellules matures humaines, au moins 30 % des cellules hématopoïétiques de la moelle osseuse du mammifère étant d'origine humaine. Le procédé de l'invention consiste à irradier de manière subléthale un mammifère immunodéficient, à introduire par perfusion les cellules hématopoïétiques humaines dans le mammifère et à administrer une quantité efficace d'un facteur de croissance de mastocytes humaines (MGF) et une protéine de fusion d'interleukine-3/facteur de stimulation d'une colonie de macrophages de granulocytes humains (GM-CSF/IL-3 FP) pour favoriser la greffe de cellules humaines dans la moelle osseuse de mammifères chimériques. The invention relates to a chimeric mammal having a stable bone marrow transplant of human hematopoietic cells capable of differentiating into multiple lines of mature human cells, at least 30% of the hematopoietic cells of the mammalian bone marrow being of origin. human. The method of the invention includes sublethally irradiating an immunodeficient mammal, infusing human hematopoietic cells into the mammal, and administering an effective amount of human mast cell growth factor (MGF) and a fusion protein. interleukin-3 / stimulating factor of a colony of macrophages of human granulocytes (GM-CSF / IL-3 FP) to promote the transplantation of human cells into the bone marrow of chimeric mammals.

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21-12-2011 дата публикации

Short beta-defensin-derived peptides

Номер: EP2396023A2
Принадлежит: Yeda Research and Development Co Ltd

The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells.

Подробнее
26-05-2005 дата публикации

Stem cells suitable for transplantation, their preparation and pharmaceutical compositions comprising them

Номер: CA2545409A1
Автор: Joy Kahn, Tsvee Lapidot

The present invention relates to stem cells suitable for transplantation and to methods for their preparation.

Подробнее
11-05-2006 дата публикации

The use of a protease or a protease inhibitor for the manufacture of medicaments

Номер: CA2586033A1
Автор: Orit Kollet, Tsvee Lapidot

The invention relates the use of a cathepsin K inhibitor (CTKI) or CTK, a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative, a salt or inducer thereof in the manufacture of a medicament for treating a disease in which SDF-1 activity and/or concentration is involved with the development and/or course of the disease.

Подробнее
12-05-2005 дата публикации

Stem cells having increased sensitivity to sdf-1 and methods of generating and using same

Номер: WO2004090120A3
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Orit Kollet, Tsvee Lapidot, Yeda Res & Dev

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

Подробнее
27-12-2007 дата публикации

Catecholamine receptor modulation

Номер: AU2007262382A1
Принадлежит: Yeda Research and Development Co Ltd

Подробнее
02-07-2013 дата публикации

Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same

Номер: CA2519975C
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Yeda Research and Development Co Ltd

The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

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15-04-2012 дата публикации

Elastasehemmer bei leukämie

Номер: ATE552888T1
Принадлежит: Yeda Res & Dev

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02-02-2011 дата публикации

Χιμαιρικη πρωτεϊνη διαλυτου υποδοχεα/συνδετη ιντepλευκινης-6, αναλογα και αυτης και χρησεις αυτης

Номер: CY1105895T1

Παρέχονται χιμαιρικές πρωτεΐνες κατασκευασμένες από την σύντηξη της φυσικά απαντώμενης μορφής του διαλυτού υποδοχέα IL-6 και της IL-6 οι οποίες είναι χρήσιμες στην θεραπευτική αγωγή καρκίνου και ηπατικών ανωμαλιών, στην ενίσχυση μεταμόσχευσης μυελού οστών, και σε θεραπευτική αγωγή άλλων σχετιζόμενων με IL-6 καταστάσεων.

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16-02-2006 дата публикации

Elastase inhibitor in leukemia

Номер: AU2005270821A1
Принадлежит: Yeda Research and Development Co Ltd

The invention relates to the use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia, preferably acute leukemia and more preferably for the treatment of AML

Подробнее
30-12-2010 дата публикации

Use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia

Номер: IL181183A

The invention relates to the use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia, preferably acute leukemia and more preferably for the treatment of AML

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24-09-2008 дата публикации

Inhibition of cxcr4 and/or cell motility by phenylalanine, cysteine or peptides containing said aminoacids

Номер: EP1971356A2
Принадлежит: Yeda Research and Development Co Ltd

The invention relates to phenylalanine, cysteine, derivatives of said amino acids, peptides comprising them, and to their use in diseases disorders or conditions whose pathology is caused by or associated with CXCR4 activity and/or cell motility.

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12-03-2007 дата публикации

Enzyminhibitor i leukemi

Номер: NO20071330L
Принадлежит: Yeda Res & Dev

Oppfinnelsen angår anvendelse av en elastaseinhibitor til fremstilling av et medikament for behandling av leukemi, fortrirmsvis akutt leukemi og mer fortrirmsvis behandling av AML.

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17-06-2003 дата публикации

Migration of hematopoietic stem cells and progenitor cells to the liver

Номер: AU2002358950A1
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Yeda Research and Development Co Ltd

Подробнее
08-09-2004 дата публикации

Migration of hematopoietic stem cells and progenitor cells to th e liver

Номер: EP1453533A1
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Yeda Research and Development Co Ltd

The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.

Подробнее
17-04-2008 дата публикации

Migration of hematopoietic stem cells and progenitor cells to the liver

Номер: AU2002358950B2
Автор: Orit Kollet, Tsvee Lapidot
Принадлежит: Yeda Research and Development Co Ltd

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