Fungicidal 2-imidazolein-5-one derivatives.

The invention relates ...

FUNGICIDES WITH HYDROXIMIC AND HYDRAZONIC GROUPS

Composés fongicides, et les compositions les contenant, de formule générale (I), dans laquelle G est choisi parmi les groupes G1 à G9, dans lesquels les divers symboles représentent des groupes organiques variés. Procédé de traitement des végétaux par application de ces composés.

5-imino derivatives 2-imidazolines fungicides

Novel imidazoline derivatives of formula (I) in which A = O or S; R1 and R2 which are the same or different are H, provided that one of the two groups is different from H, alkyl or haloalkyl(C1-C6), vinyl or allyl, alkoxyalkyl, alkylthioalkyl, alkylsulfonylalkyl; R3 is alkyl(C1-C6), cycloalkyl(C3-C6), alkoxyalkyl, alkylthioalkyl, alkenyl or alkynyl, (C2-C6), dialkylaminoalkyl, a N,N group, arylalkyl, optionally substituted by 1-3 R7; R4 is a hydrogen atom, R5 is a phenyl optionally substituted by 1-3 halogen atoms or alkyl or alkyoxy radicals with 1-3 carbon atoms; R6 is an alkylsulfonyl or a phenylsulfonyl, alkyl(C1-C20)carbonyl, phenylcarbonyl, vinylcarbonyl, alkyloxycarbonyl, phenyloxycarbonyl, alkyloxyalkylcarbonyl. The derivates of the invention are useful as agricultural fungicides.

Fungicidal 5-imino-2-imidazoline derivatives

Fungicides with hydroximic and hydrazonic groups

FUNGICIDE 2-IMIDAZOLINE-5-ONES DERIVATIVES

L'invention concerne des dérivés de 2-imidazoline-5-ones, de formule générale (I): <IMG> dans laquelle: - R1 est H, ou un groupe vinyle ou allyle, ou un radical alkyle ou haloalkyle, -n = 0u 1; Y est O ou S; - R2 est un groupe alkyle ou haloalkyle, ou le groupe cyclopropyle; - R3 est un radical aryle ou hétéroaryle, éventuellement substitué, comprenant notamment phényle, naphtyle, - R4 est un atome d'hydrogène et divers radicaux dont un radical formyle ou aroyle, un radical acyle de 2 à 6 atomes de carbone, - R5 est notamment H ou le groupe hydroxy, mercapto, nitro, cyano, thiocyanato ou azido; ou un radical alkyle ou cycloalkyle éventuellement subsitué, -W est O,S ou SO; - Ar1 est un radical divalent, éventuellement substitué, qui dérive d'un radicalaryle ou hétéroaryle comprenant, notamment, les radicaux phényle, naphtyle, thiényle, - Ar2 est un système mono ou bicyclique de 5 à 10 atomes, éventuellement substitué, qui est aromatique, saturé ou insaturé, et qui est soit un système carbocyclique, soit un système hétérocyclique contenant de 1 à 4 hétéroatomes choisis parmi O, S, ou N, - X est notamment -C(O)NH-, -NHC(O)NH-, -SO2NH-, -CH2O-, -CH2NH-, CH2-. L'invention concerne également la préparation de ces composés et leur utilisation comme fongicide à spectre large.

FUNGAL TRIAZOLE AND IMIDAZOLE DERIVATIVES

L'invention concerne de nouveaux composés à groupement triazole ou imidazole à usage phytosanitaire de formule générale: dans laquelle: W est N ou CH; E est CH2 ou 0; X est un halogène ou un radical alkyle; n est un entier de 0 à 5; R1 est un alkyle, un cycloalkyle ou un aryle; R2 est un alkyle ou un perfluoroalkyle. L'invention concerne également la préparation de ces composés et leur utilisation comme fongicides à spectre large.

New derivatives triazole and imidazol fungicides

L'invention concerne de nouveaux composés à groupement triazole ou imidazole à usage phytosanitaire de formule générale: (CF DESSIN DANS BOPI) dans laquelle: W est N ou CH; E est CH2 ou O; X est un halogène ou un radical alkyle; n est un entier de 0 à 5; R1 est un alkyle, un cycloalkyle ou un aryle; R2 est un alkyle ou un perfluoroalkyle. L'invention concerne également la préparation de ces composés et leur utilisation comme fongicides à spectre large. The invention relates to novel compounds containing a triazole or imidazole group for phytosanitary use of general formula: (CF DRAWING IN BOPI) in which: W is N or CH; E is CH2 or O; X is halogen or an alkyl radical; n is an integer of 0 to 5; R1 is alkyl, cycloalkyl or aryl; R2 is alkyl or perfluoroalkyl. The invention also relates to the preparation of these compounds and their use as broad spectrum fungicides.

Fungicidal 2-imidazolin-5-one derivatives

New fungicidal triazole and imidazole derivatives

Fungicides with hydroximic and hydrazonic groups

AMIDE DERIVATIVES; METHOD FOR THEIR MANUFACTURE AND FUNGICIDAL PREPARATIONS CONTAINING THEM

FUNGICIDES HAS GROUPS HYDROXIMIQUES AND HYDRAZONIQUES

The invention concerns fungicidal compounds, and compositions containing them, of general formula (I) in which G is selected from the groups G1 to G9: (a) in which the different symbols represent various organic groups. The invention also concerns a method for treating plants using these compounds.

NEW FUNGICIDAL TRIAZOLE AND IMIDAZOLE DERIVATIVE

PURPOSE: To obtain a new compound effective as a fungicide, especially against plant disease caused by fungi. CONSTITUTION: This new compound is a compound of formula I [wherein R1 is a 1-4C alkyl, 3-6C cycloalkyl or the like; R2 is a 1-4C alkyl, F or the like when E is other than O; R1 and R2 together form -(CH2)n- (wherein n is from 3 to 5); W is CH or N; E is O or CH; X is F, Cl, Br, a 1-4C alkyl, 1-4C alkoxy, phenoxy, CN or the like; and n is 1 to 5], e.g. 1-(4-chlorophenyl)-2-methyl-2-(2- methyl-1-hydroxy-1-(1,2,4-triazol-1-ylmethyl)-1-propyl)cyclopropane. The compound of formula I is obtained by allowing an oxirane of formula II to react with a nitrogen heterocyclic ring in the presence of a base in a solvent at from 25°C to the reflux temperature of the solvent. The obtained compound is especially effective for treating stalk diseases, leaf diseases or diseases caused by pathogenic fungi in crops such as cereals, grape, rise, corn, soybean, etc. COPYRIGHT: (C)1995,JPO ...

FUNGICIDES HAVING HYDROXIMIC AND HYDRAZONIC GROUPS

PURPOSE: Fungicidal compounds of formula(I), compositions containing them and a method for treating plants using these compounds are provided. CONSTITUTION: Novel compounds of formula(I) having hydroximic and hydrazonic groups (in which G is selected from the groups G1 to G9 and the different symbols represent various organic groups), salts and chelates thereof exhibit extensive activities for fungi and crops-pathogenic bacteria. Fungicidal compositions contain 0.05 through 95wt.% compounds of formula(I) as their active ingredient, and further contain agricultural solid or liquid supporter and/or agricultural detergent. Spreading the compounds or the fungicidal compositions to soil preventively or therapeutically exterminates the pathogenic bacteria from the crops. Additionally, coating the farm products with the compounds or the compositions prevents or treats the products and plants generated therefrom from noso-mycosis. COPYRIGHT 2000 KIPO ...

Hidroksimik ve hidrazonik gruplu fungisidler.

Mevcut bulus, G'nin G1 ila G9 gruplarindan seçilen, sözkonusu gruplarda (a)farkli sembollerin degisik organik gruplari ifade ettigi genel formül (I)'e göre olan fungisidal bilesikler ve bunlari içeren kompozisyonlarla ilgilidir. Bulus ayrica bu bilesiklerin kullanildigi bitki tedavisi için bir yöntem ile ilgilidir. The present invention relates to the fungicidal compounds according to the general formula (I) in which G is selected from the G1 to G9 groups, where (a) different symbols refer to different organic groups, and compositions containing them. The invention also relates to a method for the treatment of plants using these compounds.

DERIVES AMIDES, PROCEDE POUR LEUR FABRICATION ET COMPOSITIONS FONGICIDES LES CONTENANT

... * UN ATOME D'HYDROGENE OU D'HALOGENE, L'UN AU MOINS DE CES RADICAUX R3, R4 ET R5 ETANT AUTRE QU'UN ATOME D'HYDROGENE OU D'HALOGENE. * UN GROUPE AMINO EVENTUELLEMENT SUBSTITUE * UN GROUPE ALKYLE OU ALKOXY OU ALKYL ALKOXY OU ALKYLTHIO, EVENTUELLEMENT HALOGENE OU HYDROXYLE. * R3 ET R4 (EN POSITION META ET PARA) PEUVENT FORMER ENSEMBLE UN RADICAL UNIQUE DIVALENT A 3 OU 4 CHAINONS COMPRENANT 1 OU 2 ATOMES D'OXYGENE NON VICINAUX. LES COMPOSITIONS CONTENANT CES COMPOSES ET LEUR UTILISATION COMME FONGICIDES ...

DERIVES AMIDES PROCEDE POUR LEUR FABRICATION ET COMPOSITIONS FONGICIDES LES CONTENANT.

COMPOSES UTILISABLES NOTAMMENT POUR LE TRAITEMENT DES ATTEINTES DES PLANTES, CARACTERISES EN CE QU'ILS ONT LA FORMULE ( I) DANS LAQUELLE: LE SIGNE CYCLE ENTOURE D'UN DEMI-CERCLE REPRESENTE AVEC LES DEUX ATOMES DE CARBONE AUQUELS CE DEMI-CERCLE EST RELIE, UN CYCLE CARBONE OU HETEROCYCLIQUE COMPORTANT AU MOINS UNE LIAISON INSATUREE A CARACTERE ETHYLENIQUE OU AROMATIQUE ENTRE LES 2 ATOMES DE CARBONE PORTEURS DU GROUPE -C =Y ET DU GROUPE PHENYLE, Y EST UN ATOME D'OXYGENE OU DE SOUFRE. Z EST UN GROUPE NR1 R2. R1 ET R2 IDENTIQUES OU DIFFERENTS REPRESENTENR: UN RADICAL ALKYLE OU ALKOXY, OU CYCLOALKYLE, CES RADICAUX ETANT EVENTUELLEMENT SUSTITUES. UN RADICAL ALKENYLE OU ALKYNYLE. OU BIEN R1 ET R2 FORMENT ENSEMBLE, AVEC L'ATOME D'AZOTE AUQUEL ILS SONT RATTACHES, UN HETEROCYCLE, SATURE OU INSATURE. R3, R4 ET R 5 IDENTIQUES OU DIFFERENTS, REPRESENTENT : - UN ATOME D'HYDROGENE OU D'HALOGENE, L'UN AU MOINS DE CES RADICAUX R3 R4 ET R5 ETANT AUTRE QU'UN ATOME D'HYDROGENE OU D'HALOGENE. UN GROUPE AMINO ...

FUNGICIDAL 2-IMIDAZOLIN-5-ONE DERIVATIVE

PURPOSE: To provide fungicidal 2-imidazolin-5-ones with improved properties for treating fungal diseases of crops. CONSTITUTION: The objective 2-imidazolin-5-one derivatives are represented by formula I [wherein R1 is H, vinyl, allyl or a 1-3C (halo)alkyl; or R1 and Ar2-X-Ar1, jointly with the C linked with the imidazolinone ring to which they are linked, form a group of formula II (wherein m is 2-4); n is 0 or 1; Y is O or S; R2 is H when n is 0 or a 1-3C (halo)alkyl or cyclopropyl; R3 is phenyl, naphthyl, pyridyl, pyrimidyl, thiazolyl, benzothienyl or the like; R4 is H, formyl, an aroyl, 2-6C acyl, arylsufonyl or the like; W is O, S or SO; Ar1 is a divalent group to be derived from phenyl, naphthyl, thienyl, furyl or the like; Ar2 is a monocyclic or bicyclic system having 5-10 atoms; and X is a group of formula III] and include, e.g. (4RS)-4-methyl-2-methylthio-4-(4-phenylthiophenyl)-1- phenylamino-2-imidazolin-5-one. COPYRIGHT: (C)1995,JPO ...

NEW FUNGICIDES - DERIVATIVES OF TRIAZOL AND IMIDAZOLE

ANTIFUNGAL AGENT BASED ON AMIDE CONTAINING PHENYL GROUP

NEW MATERIAL: A compound of formula I [wherein the symbol CYCLE together with the C atoms bonded to the semicircle is a four- or seven-membered carbocyclic or heterocyclic ring having an ethylenic or aromatic unsaturation between the two C atoms; Y is O or S; and Z is NR1R2 (wherein R1 and R2 are each a lower alkyl, a lower alkoxyl, a 3-7C cycloalkyl or the like); and R3 to R5 are each H, a halogen, amino or the like]. EXAMPLE: 2-(4-Morpholinocarbonyl)-5-iodo-3-(3,4-dimethoxyphenyl)benzothiophene. USE: An antifungal agent or an intermediate thereof. PREPARATION: A benzophenone of formula II [wherein R13 to R15 are the same as R3 to R5; R16 to R19 are each the same as R6 (R6 is H, a halogen, cyano or the like); and A1 is a halogen or nitro] is reacted with a compound of formula III [wherein K10 is O, oxo or the like; and Z1 is NR11R12 (wherein R11 and R12 are the same as R1 and R2) to obtain a compound such as of formula IV. COPYRIGHT: (C)1990,JPO ...

NEW FUNGICIDAL TRIAZOLE AND IMIDAZOLE DERIVATIVES

USE OF ISATUXIMAB FOR THE TREATMENT OF MULTIPLE MYELOMA

The present disclosure provides methods for treating multiple myeloma that comprise administering isatuximab to the individual at a dose of 10 mg/kg on Days 1, 8, 15, and 22 of a first 28-day cycle; administering the isatuximab at a dose of 10 mg/kg on Days 1 and 15 of a 28-day cycle, e.g., for at least 11 cycles, or e.g., until the individual achieves or is determined to achieve at least Very Good Partial Response (VGPR) to treatment; and administering the isatuximab at a dose of 10 mg/kg once every 28 days of one or more additional 28-day cycles.

(hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them

FUNGICIDES WITH HYDROXIMIC AND HYDRAZONIC GROUPS

Fungicidal 2-imidazolin-5-one derivatives

2-IMIDAZOLINE-5-ONAS FUNGICIDE DERIVATIVE COMPOUNDS AND THEIR PROCESS FOR OBTAINING

LA INVENCION SE REFIERE A DERIVADOS DE 2-IMIDAZO- LINA-5-ONAS, DE FORMULA GENERAL 1; EN LA CUAL: -R1 ES H, O UN GRUPO VINILO O ALILO, O UN RADICAL ALQUILO O HALOALQUILO, -n = 0 o 1; Y ES 0 o S; -R2 ES UN GRUPO ALQUILO O HALOALQUILO, O EL GRUPO CICLOPROPILO; -R3 ES UN RADICAL ARILO O HETEROARILO, EVENTUAL- MENTE SUSTITUIDO, QUE COMPRENDE PARTICULARMENTE FENILO, NAFTILO, -R4 ES UN ATOMO DE HIDROGENO Y DIVERSOS RADICALES ENTRE LOS CUALES UN RADICAL FORMILO O AROILO, UN RADICAL ACILO DE 2 A 6 ATOMOS DE CARBONO, -R5 ES PARTICULARMENTE H O EL GRUPO HIDROXI, MER- CAPTO, NITRO, CIANO, TIOCIANATO O AZIDO; O UN RA- DICAL ALQUILO O CICLOALQUILO EVENTUALMENTE SUSTI- TUIDO, -W ES O, S o SO; -Ar1 ES UN RADICAL DIVALENTE, EVENTUALMENTE SUSTI- TUIDO, QUE SE DERIVA DE UN RADICAL ARILO O HETERO- ARILO QUE COMPRENDE, PARTICULARMENTE, LOS RADICA- LES FENILO, NAFTILO, TIENILO, -Ar2 ES UN SISTEMA MONO O BICICLO DE 5 A 10 ATO- MOS, EVENTUALMENTE SUSTITUIDO QUE ES AROMATICO, SATURADO O INSATURADO Y QUE ES O BIEN UN SISTEMA CARBOCICLICO, O BIEN UN SISTEMA HETEROCICLICO QUE CONTIENE DE 1 A 4 HETEROATOMOS SELECCIONADOS ENTRE O, S, o N, -X ES PARTICULARMENT -C(O)NH-, -NHC(O)NH-, -SO2NH- -CH2O-, -CH2NH-, -CH2-. LA INVENCION SE REFIERE IGUALMENTE A LA PREPARA- CION DE ESTOS COMPUESTOS Y SU UTILIZACION COMO FUNGICIDA DE AMPLIO ESPECTRO. FIGURA 1 THE INVENTION REFERS TO DERIVATIVES OF 2-IMIDAZO-LINA-5-ONAS, IN GENERAL FORMULA 1; WHERE: -R1 IS H, OR A VINYL OR ALYLUS GROUP, OR A RADICAL ALKYL OR HALOALKYL, -n = 0 or 1; Y IS 0 or S; -R2 IS AN ALKYL OR HALOALKYL GROUP, OR THE CYCLOPROPILE GROUP; -R3 IS A RADICAL ARYL OR HETEROARYL, EVENTUAL- MENTALLY SUBSTITUTED, WHICH INCLUDES PARTICULARLY PHENYL, NAPHTHYL, -R4 IS AN ATOM OF HYDROGEN AND VARIOUS RADICALS WHICH IS A RADICAL FORMYL OR AROYL 2-ACID AT AIL 2 , -R5 IS PARTICULARLY HO THE GRUPO HIDROXI, MER- CAPTO, NITRO, CIANO, TIOCIANATO OR AZIDO; OR A ROAD RENTAL OR CYCLLOALKYL EVENTUALLY SUBSTITUTED, -W IS O, S or SO; -Ar1 IS A DIVALENT RADICAL, ...

COMPOUNDS, COMPOSITIONS AND PROCESS TO FIGHT AGAINST FUNGIC ATTACKS AND PROCESS TO PREPARE COMPOUNDS

Fungicidal 5-imino-2-imidazoline derivatives

AMIDDERIVAT, DERAS FRAMSTAELLNINGSFOERFARANDE SAMT FUNGISIDA SAMMANSAETTNINGAR INNEHAOLLANDE DEM.

Derivatives of 2-imidazoline-5-ones fungicides.

L'invention concerne des dérivés de 2-imidazoline-5-ones, de formule générale (I): (CF DESSIN DANS BOPI) dans laquelle: - R1 est H, ou un groupe vinyle ou allyle, ou un radical alkyle ou haloalkyle, - n = 0 ou 1; Y est O ou S; - R2 est un groupe alkyle ou haloalkyle, ou le groupe cyclopropyle; - R3 est un radical aryle ou hétéroaryle, éventuellement substitué, comprenant notamment phényle, naphtyle, - R4 est un atome d'hydrogène et divers radicaux dont un radical formyle ou aroyle, un radical acyle de 2 à 6 atomes de carbone, - R5 est notamment H ou le groupe hydroxy, mercapto, nitro, cyano, thiocyanato ou azido; ou un radical alkyle ou cycloalkyle éventuellement subsitué, - W est O, S ou SO; - Ar1 est un radical divalent, éventuellement substitué, qui dérive d'un radical aryle ou hétéroaryle comprenant, notamment, les radicaux phényle, naphtyle, thiényle, - Ar2 est un système mono ou bicyclique de 5 à 10 atomes, éventuellement substitué, qui est aromatique, saturé ou insaturé, et qui est soit un système carbocyclique, soit un système hétérocyclique contenant de 1 à 4 hétéroatomes choisis parmi O, S, ou N, - X est notamment -C(O)NH-, -NHC(O)NH-, -SO2 NH-, -CH2 O-, -CH2 NH-, CH2 -. L'invention concerne également la préparation de ces composés et leur utilisation comme fongicide à spectre large. The invention relates to derivatives of 2-imidazolin-5-ones, of general formula (I): (CF DRAWING IN BOPI) in which: - R1 is H, or a vinyl or allyl group, or an alkyl or haloalkyl radical, - n = 0 or 1; Y is O or S; - R2 is an alkyl or haloalkyl group, or the cyclopropyl group; - R3 is an aryl or heteroaryl radical, optionally substituted, comprising in particular phenyl, naphthyl, - R4 is a hydrogen atom and various radicals including a formyl or aroyl radical, an acyl radical of 2 to 6 carbon atoms, - R5 is in particular H or the hydroxy, mercapto, nitro, cyano, thiocyanato or azido group; or an optionally substituted alkyl or cycloalkyl radical, - W is O, S ...

Novel fungicidal derivatives of triazoles and imidazoles

NYA FUNGICIDA TRIAZOL- OCH IMIDAZOLDERIVAT

Use of isatuximab for the treatment of multiple myeloma

The present disclosure provides methods for treating multiple myeloma that comprise administering isatuximab to the individual at a dose of 10 mg/kg on Days 1, 8, 15, and 22 of a first 28-day cycle; administering the isatuximab at a dose of 10 mg/kg on Days 1 and 15 of a 28- day cycle, e.g., for at least 11 cycles, or e.g., until the individual achieves or is determined to achieve at least Very Good Partial Response (VGPR) to treatment; and administering the isatuximab at a dose of 10 mg/kg once every 28 days of one or more additional 28-day cycles.

Use of isatuximab for the treatment of multiple myeloma

The present disclosure provides methods for treating multiple myeloma that comprise administering isatuximab to the individual at a dose of 10 mg/kg on Days 1, 8, 15, and 22 of a first 28-day cycle; administering the isatuximab at a dose of 10 mg/kg on Days 1 and 15 of a 28- day cycle, e.g., for at least 11 cycles, or e.g., until the individual achieves or is determined to achieve at least Very Good Partial Response (VGPR) to treatment; and administering the isatuximab at a dose of 10 mg/kg once every 28 days of one or more additional 28-day cycles.