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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 74. Отображено 74.
25-07-2023 дата публикации

Non-real-time relay communication method based on improved store-and-forward protocol

Номер: CN116488712A
Принадлежит:

The invention relates to the technical field of satellite communication, and discloses a non-real-time relay communication method based on an improved store-and-forward protocol, which is characterized by comprising the following steps: a source satellite ground station sends a message to a network management server; a relay forwarding processing module of the network management server enters an improved store-and-forward protocol process, and the processed message enters a to-be-sent state; when the target satellite ground station of the message successfully accesses the network, the message is sent to the target satellite ground station; judging whether the source satellite ground station is online; if the source satellite ground station is online, automatically establishing a link for communication; if the source satellite ground station is offline, the message replied by the target satellite ground station is processed in a relay mode; the relay module of the network management server ...

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13-04-2021 дата публикации

Temporary dust storage device for building material production line

Номер: CN212952675U

The utility model discloses a temporary dust storage device for a building material production line, which relates to auxiliary equipment in the building material production industry and comprises a horizontal spiral conveyor, a 45-degree spiral conveyor, a storage tank and a sealed ton bag, and the horizontal spiral conveyor is arranged below a dust collecting device and used for conveying collected dust. The tail end of the horizontal spiral conveyor is connected with the bottom end of the 45-degree spiral conveyor, the top end of the 45-degree spiral conveyor is connected with a feeding port of the storage tank, the storage tank is arranged in a closed dust storage chamber, and a discharging port in the bottom of the storage tank is connected with a sealed ton bag and used for storing dust and is transported out of the dust storage chamber. According to the utility model, the overflow of dust is effectively controlled, the harm of dust to the environment and personnel is reduced, and ...

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01-04-2015 дата публикации

Glass fiber reinforced polypropylene pipe production device and glass fiber reinforced polypropylene pipe production process

Номер: CN104476788A
Принадлежит:

The invention provides a glass fiber reinforced polypropylene pipe production device and a glass fiber reinforced polypropylene pipe production process and belongs to the technical field of the production of glass fiber reinforced polypropylene pipes. The glass fiber reinforced polypropylene pipe production device comprises an extruder, a vacuum feeder, a setting table, a cooling table, a cutter and a stacking rack and is characterized in that the vacuum feeder, the stacking rack, the extruder, the cooling table, a drawing unit and the cutter are orderly connected by use of a conveyor; the device is further provided with a ring stiffness detector. Due to the technical improvements, the glass fiber reinforced polypropylene pipe production device has the beneficial effects of 1, long service life, 2, excellent corrosion resistance, 3, excellent abrasion resistance, 4, excellent hygiene, 5, heat resistance, thermal insulation and energy conservation, 6, reliable connection property, 7, excellent ...

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08-08-2023 дата публикации

Electric energy meter field calibration method based on satellite high and low orbit system time service

Номер: CN116559767A
Принадлежит:

The invention belongs to the technical field of electric power overhaul, and particularly relates to an electric energy meter field calibration method based on satellite high and low orbit system time service. An alternating current signal generated by a standard signal source is converted into a frequency signal corresponding to the alternating current signal through a voltage-frequency conversion module, and then electrical parameters such as voltage, current, active power and reactive power of the alternating current signal are measured by using a high-precision clock signal provided by a satellite navigation system; and comparing the electrical parameter with the measured electrical parameter of the to-be-calibrated electric energy meter, calculating the metering error of the to-be-measured electric energy meter, and finally completing the calibration of the electric energy meter according to the metering error.

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20-05-2021 дата публикации

Simulation system and experiment method for whole evolution process of submarine slides based on a transparent clay rotating flume

Номер: AU2019436654A1
Принадлежит: Dalian University of Technology

A simulation system and an experiment method for a whole evolution process of submarine slides based on a transparent clay rotating flume belong to the technical field of marine geological disasters and geotechnical engineering experiments. The simulation system comprises a rotating flume system, a transparent clay simulation system and a control and data collection system. The rotating flume system drives the flume to rotate by controlling a motor to provide different velocities for samples. The uninterrupted ring structure of a U-shaped section rotating flume is used to meet the requirement that a sliding distance is unlimited. The transparent clay simulation system prepares transparent clay samples with tracer stains and ambient fluids with tracer stains, both of them having similar physical and mechanical properties as real marine clays and seawater, and achieves full three-dimensional visualization of the interior, exterior and fluid-clay interfaces of the whole evolution process of the sample. The control and data connection system achieves quantification monitoring and data extraction of the whole evolution process through a three-dimensional laser slicing technology and a digital image collection method. The simulation system provided by the present invention has the controlled scale, visual evolution process, measurable image data and can solve the problems of difficulty in conducting a long-distance evolution experiment, difficult data collection and unclear monitoring figure.

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03-06-2021 дата публикации

Simulation system and experiment method for whole evolution process of submarine slides based on a transparent clay rotating flume

Номер: AU2019436654B2
Принадлежит: Dalian University of Technology

A simulation system and an experiment method for a whole evolution process of submarine slides based on a transparent clay rotating flume belong to the technical field of marine geological disasters and geotechnical engineering experiments. The simulation system comprises a rotating flume system, a transparent clay simulation system and a control and data collection system. The rotating flume system drives the flume to rotate by controlling a motor to provide different velocities for samples. The uninterrupted ring structure of a U-shaped section rotating flume is used to meet the requirement that a sliding distance is unlimited. The transparent clay simulation system prepares transparent clay samples with tracer stains and ambient fluids with tracer stains, both of them having similar physical and mechanical properties as real marine clays and seawater, and achieves full three-dimensional visualization of the interior, exterior and fluid-clay interfaces of the whole evolution process of the sample. The control and data connection system achieves quantification monitoring and data extraction of the whole evolution process through a three-dimensional laser slicing technology and a digital image collection method. The simulation system provided by the present invention has the controlled scale, visual evolution process, measurable image data and can solve the problems of difficulty in conducting a long-distance evolution experiment, difficult data collection and unclear monitoring figure.

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08-09-2010 дата публикации

Ancitabine dimyristate acid ester liposome and preparation method thereof

Номер: CN0101822639A
Принадлежит:

The invention relates to an ancitabine dimyristate acid ester liposome and a preparation method thereof, belonging to the technical field of medicines. The invention overcomes the defects of difficult administration and absorption, caused by the poor water solubility of ancitabine dimyristate acid ester, and improves the treatment effect of the ancitabine dimyristate acid ester. In the invention, the liposome is prepared from 3',5'-ancitabine dimyristate acid ester which is an esterified derivative of ancitabine and auxiliary materials comprising natural adjunct lecithin, cholesterol and a stabilizer which is 2-octadecanoyl phosphatidylcholine by using a reverse phase evaporation method. The prepared liposome is an innovated novel ancitabine derivative slow-release targeting preparation and has the advantages of high encapsulation efficiency of (82.5 +/-3.2)%, even size distribution and high stability. The invention has the advantages of simple preparation process, easily controlled main ...

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12-02-2014 дата публикации

Negative polyene liquid crystal compound and mixture thereof

Номер: CN103570511A
Принадлежит:

The invention relates to a compound shown in a formula (I) and a mixture thereof. The compound shown in the formula (I) has a negative dielectric constant; in the formula (I), R1 and R2 represent hydrogen atoms or a linear alkyl group with 1 to 4 carbon atoms or a linear alkenyl group with 2 to 4 carbon atoms respectively, or R1 represents an alkoxy group or an alkenoxy group formed by substituting one or two nonadjacent CH2 in the linear alkyl group or linear alkenyl group with oxygen atoms, and 0 to 4 hydrogen atoms in the group can be substituted with fluorine or chlorine; A represents a benzene ring or a 1,4-disubstituted cyclohexane ring, and if A represents the benzene ring, 0 to 4 hydrogen atoms on the benzene ring can be substituted with fluorine; X1, X2 and X3 independently represent -CH2CH2-, -CH=CH-, -CH(CH3)CH2-, -CH2CH(CH3)-, -CH(CH3)CH(CH3)-, -CF2CF2-, -CF=CF-, -CH2O-, -OCH2-, -OCH(CH3)-, -CH(CH3)O-, -CF2O-, -OCF2-, -COO-, -OCO-, -COS-, -SCO-, -(CH2)3O-, -O(CH2)3-, -(CH2)4 ...

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26-01-2011 дата публикации

3', 5'-cyclocytidine dilaurate ether lipsome and preparation method thereof

Номер: CN0101953786A
Принадлежит:

The invention discloses a lipsome preparation of a new cyclocytidine derivative for treating leucocythemia, malignant lymphoma and some entity tumors and a preparation method thereof, belonging to the technical field of medicament. The inventor modifies the molecular structure of cyclocytidine to prepare the esterified derivative of 3', 5'-cyclocytidine dilaurate ether of the cyclocytidine and adopts a reversed-phase evaporation method to prepare the lipsome by utilizing 3', 5'-cyclocytidine dilaurate ether and the auxiliary materials of natural lecithin, cholesterol and a stabilizer of distearic acyl phosphatidyl choline. The prepared lipsome is an original slow release targeting preparation of the new cyclocytidine derivative, not only has high entrapment efficiency (86.8+/-2.4 percent) but also has the characteristics of uniform grain fineness distribution and high stability, enhances the treatment effect of drugs and overcomes the defects of difficult drug administration and difficult ...

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18-05-2011 дата публикации

Automatic vegetable cutting machine

Номер: CN0102059713A
Принадлежит:

The invention discloses an automatic vegetable cutting machine. The machine consists of an electric motor, a round wheel, shafts, a spherical hinge, a connecting bar, a blade, a bracket with a chute and a flat panel pedestal, wherein the electric motor is directly connected with the round wheel; one shaft is vertically connected to a position of one third of the radius from the edge of the round wheel to a circle center on a circular surface, and is vertically connected with the connecting bar by the spherical hinge; the connecting bar is movably connected to the middle part of the other shaft; the blade is fixedly connected with the second shaft; the two ends of the second shaft are put in the chute of the bracket with the chute; and the bracket and a conveyor belt are fixed on the flat panel pedestal.

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02-09-2015 дата публикации

Self-coordinated transverse micromotion loading device for micromotion fatigue testing

Номер: CN104880362A
Принадлежит:

The invention relates to a self-coordinated transverse micromotion loading device for micromotion fatigue testing. The self-coordinated transverse micromotion loading device comprises a fixed base and two cantilever beams which are arranged side by side; the middle parts of two cantilever beams are testing stations for placing a tubular product to be tested, a bearing is fixed at one end of one of the cantilever beams and is arranged at the outer side of the cantilever beam relative to the other cantilever beam, the bearing can be rotationally arranged on a rotating shaft which is located on the fixed base, and a loading mechanism is arranged at the free ends of the two cantilever beams and is used for adjusting a distance between two cantilever beams and for micromotion loading. The self-coordinated transverse micromotion loading device for micromotion fatigue testing has good stability, high reliability and high precision, and has a loading self-coordination function.

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06-01-2016 дата публикации

A sampling device for confined reaction vessel or storage tank

Номер: CN0204944885U
Принадлежит:

The utility model discloses a sampling device for confined reaction vessel or storage tank, looking the legendary venomous insect and taking a sample the tubular column including vertical setting, the upper end of looking the legendary venomous insect with the lower extreme detachable of sample tubular column links together and feeds through each other, transversely be provided with the spool in the sample tubular column the lateral wall of sample tubular column corresponds wire winding the shaft position is provided with and connects through the connecting piece the crank of spool one end rotates the crank drives the spool and is in the axial is rotated in the sample tubular column, the winding has the sample line on the spool, the one end of sample line is connected the spool, the other end stretches into downwards look in the legendary venomous insect and be connected with and follow the sampling bottle of displacement about the spool rotates, the upper end shutoff of sample tubular ...

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20-11-2002 дата публикации

Electronic light-controlling or sound-controlling music instrument 'Bayinqin'

Номер: CN0001380643A
Принадлежит:

The invention relates to 'eight-tones' music instrument with the light and tones being controlled by the electric circuit. The instrument includes the fixed seat, triggering lead, the fixed mount, the upper contact piece, lower contact piece and the outside end cover of the sound tube etc. The outside end cover of the sound tube includes the ring and the non-metallic end cover. There are metallicconductive contacts with distance between each other on the ring. The dentations on the ring cover up the excircle surface of the non-metallic end cover. When the instrument is rotating, the outside end cover of the sound tube follows, the heads of the upper contact piece, lower contact piece keep contact with the ring, making the control circuit turn on. Then, the program starts running to shineor phonate.

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26-03-2014 дата публикации

Multi-tune eight-tone musical instrument

Номер: CN103680482A
Принадлежит:

The invention discloses a multi-tune eight-tone musical instrument which comprises a driving mechanism, a transmission gear, a tone barrel component, a connecting gear, tablets, a damping gear and a speed regulating component. The multi-tune eight-tone musical instrument further comprises a multi-tune mechanism, a braking mechanism and a tune exchanging mechanism. The eight-tone musical instrument is braked through the braking mechanism, and multiple tunes are played and exchanged through the multi-tune mechanism and the tune exchanging mechanism. The multi-tune eight-tone musical instrument has the advantages that the multiple tunes can be played through one eight-tone musical instrument mechanism, particularly a single circle of rotation of the tone barrel component, compact integration of the multiple tunes is realized in combination with the tune exchanging mechanism, and therefore the structure is compact; a wind on a rocking crank is shaken and shifted with the right hand to provide ...

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04-08-2010 дата публикации

Method and system for processing information data

Номер: CN0101794297A
Принадлежит:

The invention discloses a method and a system for processing information data. The method comprises the following steps of: firstly, saving corresponding PSDR data in a PSDR file according to a user number segment; secondly, receiving user UDR data and dividing the UDR data according to the user number segment and saving the UDR data in the UDR file; and finally, loading the PSDR file needed to be updated in an internal memory, determining the PSDR data in the PSDR file, reading the UDR data which corresponds to the PSDR data and belongs to the same user number segment as the PSDR data, and updating the PSDR file. According to the method and the system for processing the information data, the PSDR data of a user number is saved in the PSDR file in a hard disk; and when update is needed, the PSDR file is mapped into the internal memory and then the information data is updated, so not only the use of the internal memory space is reduced, but also the update efficiency of the information data ...

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18-05-2011 дата публикации

Automatic temperature- control smoke-abatement moxibustion device

Номер: CN0102058475A
Принадлежит:

The invention relates to an automatic temperature-control smoke-abatement moxibustion device which comprises a cylinder, a gear guide rail, a gear, a moxa stick clip, a filter screen with activated carbon, an ash removal cover, a medicament clip, a temperature sensor and a fixing strap, wherein the gear guide rail is arranged at one side of the cylinder with a through hole; the gear and the gear guide rail are meshed; the gear and a motor are connected; the motor is connected with a singlechip; the moxa stick clip is sleeved on the gear; the lower part of the interior of the cylinder is provided with the ash removal cover; the cover is installed below the medicament clip; and the temperature sensor is placed at one side of the medicament clip. A patient send signals to the singlechip through a remote controller; the motor is controlled through the singlechip to drive the gear and the moxa stick clip to move up and down along the gear guide rail, so that the distance between a moxa stick ...

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26-08-2015 дата публикации

Porphyra seedling culture method and culture pond body

Номер: CN104855268A
Автор: WANG JIBO
Принадлежит:

The invention provides a porphyra seedling culture method. According to the method, porphyra seedlings are inoculated on a carrier shell, and suspended type porphyra seedling culture is carried out in a shell suspension manner. The invention further discloses a culture pond body used by the culture method. The culture pond body comprises a basket-shaped pond main body made of a transparent material; a plurality of supporting rods are arranged on the basket-shaped pond main body; the supporting rods are arranged on the upper edge of the basket-shaped pond main body in an erection manner or arranged on the basket-shaped pond main body in a fixed connection manner. According to the invention, culture is carried out by adopting the carrier shell suspension manner, so that the method is a safe and efficient porphyra seedling culture method; the culture space is used fully and the culture area can be increased by 10 times or above as compared with that of a pond bottom paving manner, so that ...

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25-07-2012 дата публикации

Method and system for processing information data

Номер: CN0101794297B
Принадлежит:

The invention discloses a method and a system for processing information data. The method comprises the following steps of: firstly, saving corresponding PSDR data in a PSDR file according to a user number segment; secondly, receiving user UDR data and dividing the UDR data according to the user number segment and saving the UDR data in the UDR file; and finally, loading the PSDR file needed to be updated in an internal memory, determining the PSDR data in the PSDR file, reading the UDR data which corresponds to the PSDR data and belongs to the same user number segment as the PSDR data, and updating the PSDR file. According to the method and the system for processing the information data, the PSDR data of a user number is saved in the PSDR file in a hard disk; and when update is needed, the PSDR file is mapped into the internal memory and then the information data is updated, so not only the use of the internal memory space is reduced, but also the update efficiency of the informationdata ...

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18-05-2011 дата публикации

Self-cleaning dining table

Номер: CN0102058244A
Принадлежит:

The invention provides a self-cleaning dining table which comprises a dining table, a controllable circuit, axles, a table cloth wiper and rotatable table cloth, wherein the controllable circuit is positioned in the dining table; two sides of the dining table are provided with the two axles, the axles are connected with a motor, the motor is connected with the controllable circuit, and the controllable circuit is connected with a switch button arranged on a leg of the dining table; the movable table cloth is wound on the top of the dining table and the exteriors of the axles; and the table cloth wiper is arranged on the lower part of the top of the dining table. By using the self-cleaning dining table, the problem of low cleaning efficiency as a result of the fact that the dining table can not be cleaned timely under the condition that many persons have meals in a restaurant is solved, thereby reducing the workload of cleaners, and improving the cleaning efficiency of the dining table.

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04-03-2015 дата публикации

Cloth inspection machine current and voltage type double-roller synchronization controller

Номер: CN104393796A
Принадлежит:

The invention relates to a synchronization controller, and particularly relates to a cloth inspection machine current and voltage type double-roller synchronization controller. The invention provides the cloth inspection machine current and voltage type double-roller synchronization controller by aiming at defects in the prior art that a control circuit structure is complex, failure rate is high and synchronization adjusting is inconvenient so as not to be adaptive to the requirement of mass production. The cloth inspection machine current and voltage type double-roller synchronization controller comprises a cloth-winding roller frequency converter BP1, a cloth-winding roller motor M1, a cloth-loading roller frequency converter BP2, a cloth-loading roller motor M2, a potentiometer RP and three stages of operational amplification circuits. The cloth-winding roller frequency converter BP1 is a driving controller, and the cloth-loading roller frequency converter BP2 is a driven controller.

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10-08-2011 дата публикации

Ginger and clove composition, preparation method of ginger and clove composition and use of ginger and clove composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy

Номер: CN0102145158A
Принадлежит:

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and clove, gingerol, clove ethanol extract and eugenol based on the proportion of 3 to 6: 2 to 5: 3 to 5: 2 to 9, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

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18-05-2011 дата публикации

Device for automatically cleaning chewing gum on floor

Номер: CN0102058354A
Принадлежит:

The invention relates to a device for automatically cleaning chewing gum on a floor. The device comprises a controllable container in which dry ice is filled, a dry ice control button, a cutter button, a grab handle, a cutter, a rubber eraser and a straight bar with a circuit, wherein the lower end of the cutter consists of a rotatable blade which can be controlled to be opened or closed; the straight bar is provided with the dry ice control button and the cutter button; the dry ice control button is connected with the container in which the dry ice is filled through a line to control releasing of the dry ice and stopping of the releasing; the cutter button of the cutter is connected with a controller, namely the cutter, of the rotatable blade to control the rotatable closing and opening of the rotatable blade and the stopping of the rotatable closing and rotatable opening; the rubber eraser is fixed above the rotatable blade; and when the rotatable blade is opened by rotating, the chewing ...

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18-05-2011 дата публикации

Automatic seal machine

Номер: CN0102059862A
Принадлежит:

The invention provides an automatic seal machine which comprises a scanner, a paper feeding system and an automatic seal system, wherein the scanner is connected with the paper feeding system, the paper feeding system is connected to a conveyor belt of the automatic seal system, a manual sliding guide rail is arranged on the conveyor belt, an automatic seal arm is arranged on the manual sliding guide rail, the automatic seal arm is connected to a gear through a pulley with an electrical machine, and an inkpad groove is connected to one side of the conveyor belt. The scanner is connected with a computer, the sealed file is sent to a computer after scanned by the scanner, then the computer sends data, thus automatic seal is realized through setting the speed of the conveyor belt and the slipping manner of the seal arm along the guide rail. According to the invention, the problem of time and energy waste in a process of sealing a large number of same files is mainly solved, and a seal task ...

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24-09-2014 дата публикации

Four-station forging die for pull rod of railway turnout opening

Номер: CN104057008A
Принадлежит:

The invention discloses a four-station forging die for a pull rod of a railway turnout opening, belongs to the technical field of forging, and particularly relates to machining equipment for railway turnouts. The forging die comprises an upper die, a lower die and a four-station puncher chip, the appearance of the upper die and the lower die is a rectangular cube, and the lower die is located under the upper die. Four semicircular insert grooves are evenly formed in the upper end face of the lower die in sequence, and an insert is arranged in each insert groove. The upper die is located over the lower die, four semicircular insert grooves are evenly formed in the lower end face of the upper die in sequence, and an insert is arranged in each insert groove. After the upper die and the lower die are closed, a closed cavity for material collecting, pre-forging, finish forging and edge cutting is formed. The four-station forging die is used in cooperation with forging equipment, a four-station ...

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04-08-2004 дата публикации

电子控灯或控声八音琴

Номер: CN0001160695C
Принадлежит:

... 本发明涉及一种电子控灯或控声的八音琴它包含有固定座(1)、与带电子控制电路的印刷板相连的触发导线(2)、(2’)、固定架(3)、上触片(4)、下触片(5)及音筒外侧端盖(6)等组成。音筒外侧端盖(6)包含有配以带金属间隔导电块的圈状物(61)、音筒非金属的端盖(62)组成;其特征在于:所述的配以带金属间隔导电触点的圈状物(61)的齿状凸起包住非金属的端盖(62)的外圆表面,同时与非金属的端盖(62)之间呈相同间隔的形状分布,并嵌合成一个整体。当八音琴运转时,外侧端盖(6)随八音琴的音筒部件(7)转动,上触片(4)与下触片(5)的头部同时与配以带金属间隔导电块的圈状物(61)保持接触,使电子控制电路导通,并按内部设置的程序开始发光或发声;所述的音筒外侧端盖(6)呈圆环形,并随八音琴的音筒部件(7)转动,上触片(4)与下触片(5)的头部与音筒外侧端盖(6)的环形圆周表面保持持续的弹性接触,且其工作状态中两者间的距离明显加大,即使该装置在振动的环境中,也不易引起弹性上、下触片(4、5)的误触发,从而提高了发光体或喇叭动作功能的可靠性。 ...

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20-01-2016 дата публикации

Heavy -calibre breaker

Номер: CN0204974084U
Принадлежит:

The utility model provides a heavy -calibre breaker, belongs to the technical field of plastic tubing production, is configure by inside parcel operator axle of box and main shaft, and the main shaft frame is connected with dividing the arbor, as the utility model discloses a further improvement divides the arbor to be connected with dividing the pedestal, the main shaft frame is the axial symmetry, equidistance between every support, and prismatic frame is connected with the main shaft frame. Through the above technical improvement, the utility model, reached following beneficial effect: not needing great power just can reach crushing effect during the use, only needing less engine, the power consumption is low, and output is high, the energy saving, and the crushing efficiency that has wherein divided the great improvement of the use of pedestal, crushing effect has had very big promotion.

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23-06-2010 дата публикации

Anode preparation method for producing solid oxide fuel cell of acrylic acid

Номер: CN0101752584A
Принадлежит:

The invention relates to an anode preparation method for producing a solid oxide fuel cell of acrylic acid. Electrolyte of the cell is Bi4Cu0.2V1.8O11-delta, and cathode materials are Ag-Bi4Cu0.2V1.8O11-delta with the weight ratio: Ag:Bi4Cu0.2V1.8O11-delta =(0.5-1):(0.2-1); anode materials adopted by the cell are Mo-V-Te(Sb)-Nb-O and concretely comprise Mo element and at least one element of V, Te, Sb and Nb; and the mol ratio among Mo, V, Te, Sb and Nb is 1:(0-0.5):(0-0.4):(0-0.3):(0-0.3). The invention has the advantages of high reaction conversion rate, low reaction temperature and high selectivity, always keeps the selectivity of the acrylic acid at about 72.8 percent, and can simultaneously produce power and the acrylic acid.

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31-08-2011 дата публикации

Ginger and long pepper composition as well as preparation method and application thereof in preparation of toxicity reducing and efficacy enhancing medicament in radiotherapy and chemotherapy of cancer

Номер: CN0102166335A
Принадлежит:

The invention relates to a natural medicine composition as well as a preparation method and application thereof in preparation of a toxicity reducing and efficacy enhancing medicament in radiotherapy and chemotherapy of cancer. The natural medicine composition is prepared from a ginger and long pepper decorated concentrated extract, gingerol, a long pepper ethanol extract and piperine at a ratio of (2-8):(1-4):(2-4):(3-9). The composition has an extremely good efficacy for vomiting and other side effects caused by radiotherapy and chemotherapy of cancer, and simultaneously plays a role in suppression of tumors.

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06-02-2008 дата публикации

Composite material and musical movements baseboard

Номер: CN0101117439A
Принадлежит:

A composite material comprises of the following percentage by weight compositions of components: 35 percent to 50 percent of polyphenylene sulfide, 35 percent to 45 percent of ataple glass fiber (GFR), 2 percent to 5 percent of ordinary (AS) carbon fiber, 3 percent to 8 percent of silicane coupling agent (KH-560), 3 percent to 6 percent of alumina crystal whisker, 1.5 percent to 3.5 percent of graphite powder, 3 percent to 7 percent of FUKKOL solvent and 0 percent to 5 percent of pure iron powder. The invention has the advantages that: the composite material which has excellent performances such as high rigidity, high mechanical strength, chemical corrosion resistance, abrasion resistance and self lubrication can replace metal and non-ferrous alloy material to reduce the consumption of metal and non-ferrous alloy material, thereby increasing competitive power of product; meanwhile, eight-tone musical instrument assembled by the bottom board made from the composite material possesses the ...

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24-09-2014 дата публикации

Combined frog with core rail and wing rail embedding blocks adopting forged high manganese steel

Номер: CN104060503A
Принадлежит:

The invention provides a combined frog with a core rail and wing rail embedding blocks adopting forged high manganese steel, and belongs to the technical field of railway turnout manufacturing. The combined frog adopts a splicing combined structure, a wing rail adopts an embedding block type structure and consists of main wing rails and wing rail embedding blocks through embedding, the core rail is arranged in the center of the combined frog, the two sides of the core rail are provided with the two main wing rails symmetrical along the center axial line of the core rail, and two symmetrical wing rail embedding blocks are embedded in the inner sides of throat space positions of the two main wing rails. Two separation iron blocks are embedded in the front ends and the middle positions of the wing rail embedding blocks, and two pairs of symmetrical trapezoidal separation iron blocks are arranged at the inner sides of the back ends of the two symmetrical wing rail embedding blocks, the two ...

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19-12-2012 дата публикации

Automatic sealing machine

Номер: CN0102059864B
Принадлежит:

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25-07-2012 дата публикации

Composite material and musical movements baseboard

Номер: CN0101117439B
Принадлежит:

A composite material comprises of the following percentage by weight compositions of components: 35 percent to 50 percent of polyphenylene sulfide, 35 percent to 45 percent of ataple glass fiber (GFR), 2 percent to 5 percent of ordinary (AS) carbon fiber, 3 percent to 8 percent of silicane coupling agent (KH-560), 3 percent to 6 percent of alumina crystal whisker, 1.5 percent to 3.5 percent of graphite powder, 3 percent to 7 percent of FUKKOL solvent and 0 percent to 5 percent of pure iron powder. The invention has the advantages that: the composite material which has excellent performances such as high rigidity, high mechanical strength, chemical corrosion resistance, abrasion resistance and self lubrication can replace metal and non-ferrous alloy material to reduce the consumption of metal and non-ferrous alloy material, thereby increasing competitive power of product; meanwhile, eight-tone musical instrument assembled by the bottom board made from the composite material possesses the ...

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18-05-2011 дата публикации

Automatic sealing machine

Номер: CN0102059864A
Принадлежит:

The invention relates to an automatic sealing machine which mainly comprises a base, a master gear, an auxiliary gear, two gear grooves, a rubber conveying belt connecting the master gear and the auxiliary gear, an electromagnet, a motor, a miniature robotic arm, a robotic arm bracket, two singlechips which respectively control the motor and the miniature robotic arm, two direct current power supplies, a slideable objective table and relevant circuits. For the device, firstly the two gear grooves are fixed on a base plate; then the two gears are fixed on the gear grooves; then two gears are connected through the conveying belt; a gear shaft is connected with the motor; the motor is connected with the singlechip I; the singlechip I and the power supply I are connected; the movable objective table is fixed on a fixed bracket; the robotic arm bracket is fixed on the movable objective table; the robotic arm is connected to the singlechip II; and the singlechip II is connected with the power ...

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16-09-2015 дата публикации

Horizontal fine motion loading device of self tuning mode fine motion fatigue test

Номер: CN0204649527U
Принадлежит:

The utility model provides a horizontal fine motion loading device of self tuning mode fine motion fatigue test, includes unable adjustment base, horizontal fine motion loading device also includes two cantilever beams, and two cantilever beams arrange side by side, and the middle part of two cantilever beams is for being used for placing the experimental station of treating experimental tubular product, the one end fixing bearing of cantilever beam, the bearing is located the outside of a cantilever beam for another cantilever beam, the bearing is rotationally installed in the shaft, the shaft is located unable adjustment base, the free end installation of two cantilever beams is used for adjusting distance and the loaded load mechanism of fine motion between two cantilever beams. The utility model provides a dough stability is good, good reliability, precision are high, have the horizontal fine motion loading device of self tuning mode fine motion fatigue test of load from the coordinative ...

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02-01-2008 дата публикации

Music box

Номер: CN0101097712A
Принадлежит:

Eight-tone lyre, especially relates to a kind of Eight-tone lyre made by eight-tone soleplate made of multiplex material made of colophony, which includes eight-tone soleplate with bracket of rest pin, clockwork spring box, and voice canister, and through hole is mounted on said soleplate, and the fixing pin is mounted on the corresponding clockwork spring box, and the fixing pin is fixed by ultrasonic rivet pass the through hole. The advantages of invention are that: because the fixing pin is mounted on clockwork spring box and the through hole is mounted on the soleplate, and the voice box and soleplate can be riveted on the rear face of soleplate, and there is big space which is convenient to rivet, it can improve the manufacturing efficiency for eight-tone lyre, and also improve the quality and the percent of pass of eight-tone lyre.

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18-05-2011 дата публикации

Skin moxibustion device

Номер: CN0102058474A
Принадлежит:

The invention relates to a moxibustion device capable of automatically controlling temperature and removing smoke, comprising three different-sized regular three-square bodies with through holes, fixing ropes, filter screens in which activated carbon is embedded, and the like. A patient puts a litten moxa into a corresponding container according to the size of the litten moxa and then puts the container on a corresponding acupuncture point; and in addition, the patient can cap the filter screens in which the activated carbon is embedded on the container to remove smoke smell according to personal needs. Fixing bands at the two sides of the moxibustion device can be used for bonding the moxibustion device to the acupuncture point in need of treatment, so that the patient can normally move and work when receiving the treatment.

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21-01-2009 дата публикации

Use of indole-2,3-diketone in preparing external-use preparation for treating gynecology colpitis

Номер: CN0101347426A
Принадлежит:

The invention relates to an application of indole-2, 3-dione in preparing an external preparation for treating gynecological vaginitis. The indole-2, 3-dione is a natural product or an artificially synthesized product, which has low toxicity, little side effect and no irritation to vagina as well as has good effect in alleviating the vaginitis. The indole-2, 3-dione is a reliable and safe medicine for treating gynecological vaginitis.

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30-05-2012 дата публикации

Ginger and clove composition, preparation method of ginger and clove composition and use of ginger and clove composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy

Номер: CN0102145158B
Принадлежит:

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and clove, gingerol, clove ethanol extract and eugenol based on the proportion of 3 to 6: 2 to 5: 3 to 5: 2 to 9, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

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27-10-2010 дата публикации

Mixed conducting oxygen-permeable membrane and preparation method and application thereof

Номер: CN0101869809A
Принадлежит:

The invention provides a mixed conducting oxygen-permeable membrane and a preparation method and application thereof. The oxygen-permeable membrane comprises a plurality of elements selected from Mo, V, Te, Sb, Bi, Nb and O, the relative molar ratio of Mo is more than 0.25 and less than 1, the relative molar ratio of V is more than 0.003 and less than 0.5, the relative molar ratio of Te is more than 0 and less than 0.5, the relative molar ratio of Sb is more than 0 and less than 0.5, the relative molar ratio of Bi is more than 0 and less than 0.5, the relative molar ratio of Nb is more than 0and less than 0.5, and the relative molar ratio of O is more than 3 and less than 6. The preparation method comprises the following steps: weighing, mixing and grinding the raw materials, pre-treating in the air atmosphere, roasting in the protective atmosphere, raising the temperature to 200-300 DEG C from the room temperature at a rate of 1-5 DEG C per minute, and keeping the temperature for 1-3 hour ...

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17-06-2015 дата публикации

Traditional Chinese medicine composite for treating spleen deficiency and dampness-heat type hyperlipidemia

Номер: CN104706962A
Автор: WANG JIBO
Принадлежит:

The invention relates to a traditional Chinese medicine composite for treating spleen deficiency and dampness-heat type hyperlipidemia, which consists of the following traditional Chinese medicinal materials: 5-10g asparagus officinalis, 10-20g silkworm chrysalis, 5-15g bauhinia championii, 3-8g kadsura longipedunculata finet et gagn, 5-18g conic gymnadenia tuber, 3-8g diversifolious pimpinella herb, 2-5g himalayan eriosema roots, 3-15g medicinal fermented mass, 5-10g illicium verum, 10-20g hyacinth-bean flowers, 10-15g beechey fig roots, 5-10g flaccid knotweed herb and 10-25g Chinese angelica. The traditional Chinese medicine composite has the efficacies of regulating qi, strengthening a spleen, warming yang and removing dampness, has an obvious curative effect on spleen deficiency and dampness-heat type hyperlipidemia, takes effect rapidly, and has high efficiency and no toxic or side effect.

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11-11-2015 дата публикации

Breed cell body of laver seed

Номер: CN0204742120U
Автор: WANG JIBO
Принадлежит:

The utility model relates to a breed cell body of laver seed should breed the basket pond body that the cell body includes that transparent material makes, was equipped with a plurality of bracing pieces on the body of basket pond, the bracing piece to adopt the mode erect to establish on the body of basket pond the edge last, perhaps adopt fixed connection's mode to establish on the body of basket pond. The utility model discloses probably be applicable to and adopt the mode that hangs the carrier shell to carry out the laver seed, make the cultivation safe, high -efficient, utilized the breed space widely, compare bottom of the pool tiling mode, can improve the cultured area and reach more than 10 times, improved the output of unit cultured area widely, practiced thrift the manual work, also be difficult to take place the infectiousness disease. This breeds cell body simple structure, and reasonable in design is visual strong, can carry out audio -visual breed and observe.

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01-08-2023 дата публикации

Method for quickly reinforcing steel bars of bridge raw material

Номер: CN116522637A
Принадлежит:

The invention relates to the technical field of bridge construction, in particular to a method for rapidly reinforcing steel bars of a bridge raw material. Comprising the following steps that s1, a BIM steel bar model is imported; s2, introducing the component and endowing the component with a lap joint attribute; s3, automatically distributing reinforcing steel bar raw materials for collocation; s4, analyzing steel bar distribution optimization statistics; and s5, exporting the allocated matching scheme, and transferring to a processing plant for production. On the premise that relevant standards and design requirements are met, according to the specifications and component types of reinforcing steel bar raw materials, reinforcing steel bar lap joint schemes are automatically calculated and distributed, reasonable matching is achieved, the situations of waste, waste and the like of reinforcing steel bars are avoided, the loss rate of the reinforcing steel bars is remarkably reduced, the ...

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16-07-2014 дата публикации

One-die two-piece forging die for railway track gauge block

Номер: CN103920840A
Принадлежит:

The invention relates to a forging die, in particular to machining, installing and using of a one-die two-piece forging die for a railway track gauge block. The die comprises an upper die body and a lower die body. The upper die body and the lower die body are of rectangular cube shapes. The upper die body is arranged on the lower die body, and the lower die body is arranged under the upper die body. According to the design structure of the die, the upper die body and the lower die body are provided with locating key grooves, locking buckles and dovetails. When the die is used cooperatively with punching equipment, automatic centering of a cavity can be achieved by buckling the upper die body and the lower die body, then an upper locating key and a lower locating key are installed, the die can be used after being directly connected with the equipment through inclined iron, and the one-die two-piece railway track gauge block forging task can be finished conveniently and fast. Compared with ...

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25-10-1995 дата публикации

Drive structure of musical box

Номер: CN0001110621A
Принадлежит:

The outward driving structure for music box has a supporter parallel to its base plane. A power output axle vertically arranged to the supporter is connected to drive unit from clockwork spring at its lower end and the external body (for example, doll) connected to its top end. If it is connected with crank connecting mechanism, a swing rotation output with speed regulation is realized.

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31-01-2024 дата публикации

Terapeútica con arn novedosos y usos de estos

Номер: ECSP23096460A
Принадлежит: Lilly Co Eli

La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8.

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29-12-2022 дата публикации

Novel rna therapeutics and uses thereof

Номер: CA3224145A1
Принадлежит: Eli Lilly and Co

The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression.

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29-02-2024 дата публикации

Terapeútica con arn novedosos y usos de estos

Номер: DOP2023000283A
Принадлежит: Lilly Co Eli

La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8.

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10-05-2024 дата публикации

Terapeútica con arn novedosos y usos de estos

Номер: CO2023018345A2
Принадлежит: Lilly Co Eli

La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos 5 opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8

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01-05-2024 дата публикации

Novel rna therapeutics and uses thereof

Номер: EP4359530A1
Принадлежит: Eli Lilly and Co

The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression.

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27-09-2023 дата публикации

Nuevos tratamientos de arn y usos de estos

Номер: AR126206A1
Принадлежит: Lilly Co Eli

La presente descripción se refiere a nuevos agentes de ARNi diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un conector. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8. Reivindicación 1: Un agente de ARN de interferencia (ARNi) que comprende un resto de administración de fórmula (1), en donde R comprende una cadena sentido y una cadena antisentido, en donde la cadena antisentido comprende al menos 15 nucleótidos contiguos de una secuencia seleccionada del grupo que consiste en SEQ ID Nº 405 - 525, y en donde la cadena sentido y la cadena antisentido forman una región de complementariedad de al menos 15 nucleótidos, y en donde la cadena sentido y la cadena antisentido tienen cada una independientemente de 18 a 23 nucleótidos de longitud, y opcionalmente en donde la cadena sentido y la cadena antisentido comprenden cada una independientemente uno o más nucleótidos modificados, y opcionalmente en donde la cadena sentido y la cadena antisentido comprenden cada una independientemente uno o más enlaces internucleotídicos modificados, y en donde R está opcionalmente conjugado con la fórmula (1) a través de un conector. Reivindicación 6: El agente de ARNi de una cualquiera de las reivindicaciones 1 a 5, en donde la cadena antisentido se selecciona del grupo que consiste en SEQ ID Nº 231 - 361, o una secuencia que tiene al menos 90% de identidad de secuencia con estas. Reivindicación 7: El agente de ARNi de una cualquiera de las reivindicaciones 1 a 6, en donde la cadena sentido se selecciona del grupo que consiste en SEQ ID Nº 124 - 230, o una secuencia que tiene al menos 90% de identidad de secuencia con estas. Reivindicación 8: El agente de ARNi de una cualquiera de las reivindicaciones 1 a 7, en donde, en la región de complementariedad, comprende 0, 1, 2 o 3 ...

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13-03-2024 дата публикации

Agentes de interferencia de arn de mapt

Номер: AR127942A1
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de ARNi de MAPT y composiciones que comprenden un agente de ARNi de MAPT. En la presente descripción también se proporcionan métodos para usar los agentes de ARNi de MAPT o composiciones que comprenden un agente de ARNi de MAPT para reducir la expresión de MAPT y/o tratar una tauopatía en un sujeto.

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12-03-2024 дата публикации

MAPT RNA interference agents

Номер: US11926827B2
Принадлежит: Eli Lilly and Co

Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

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27-06-2024 дата публикации

Novel rna therapeutics and uses thereof

Номер: WO2024138111A1
Принадлежит: ELI LILLY AND COMPANY

The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.

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27-06-2024 дата публикации

NOVEL FAS RNAi THERAPEUTICS AND USES THEREOF

Номер: WO2024137729A1
Принадлежит: ELI LILLY AND COMPANY

The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the FAS receptor (expressed by the FAS gene), thereby decreasing expression of FAS mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of FAS expression and function, such as autoimmune hepatitis.

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26-10-2023 дата публикации

Mapt rna interference agents

Номер: US20230340482A1
Принадлежит: Eli Lilly and Co

Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

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22-06-2023 дата публикации

Mapt rna interference agents

Номер: CA3240999A1
Принадлежит: Eli Lilly and Co

Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Подробнее
13-06-2024 дата публикации

Mapt rna interference agents

Номер: AU2022410845A1
Принадлежит: Eli Lilly and Co

Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Подробнее
27-06-2024 дата публикации

Novel rna therapeutics and uses thereof

Номер: WO2024138105A1
Принадлежит: ELI LILLY AND COMPANY

The present disclosure relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the HMGCR receptor (expressed by the HMGCR gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases and disorders involving the regulation of HMGCR expression and function, such as diseases and disorders that are risk factors for ASCVD (such as, dyslipidemia, such as hypercholesteremia).

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30-12-2021 дата публикации

Led bulb

Номер: US20210404618A1
Принадлежит: Zhejiang Yankon Mega Lighting Co Ltd

An LED bulb includes an LED photoelectric module having at least two branches of LED beads with different color temperatures connected in parallel, a control switch connected with one of the branches of LED beads, and an adjustment ring. A total voltage of one branch of LED beads is less than that of each of the other branches of LED beads. The control switch has a ball, the adjustment ring has a magnet, and when the adjustment ring rotates, the magnet draws the ball to roll to switch on or off the control switch. When the control switch is on, the branch of LED beads connected with the control switch is lighted up, and when the control switch is off, the branch of LED beads connected with the control switch is not lighted up.

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13-06-2024 дата публикации

Modified oligonucleotides

Номер: WO2024123646A2
Принадлежит: ELI LILLY AND COMPANY

Aspects of the disclosure relate to compositions and methods for modulating levels, function, and/or activity one or more RNA transcripts (e.g., mRNA transcripts) or the proteins in a cell or subject. The disclosure is based, in part, on chemically modified inhibitory nucleic acids that are capable of target RNA knockdown with high specificity and low off-target effects.

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18-07-2024 дата публикации

Agentes de interferencia de arn de mapt

Номер: CO2024007285A2
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de iARN de MAPT y composiciones que comprenden un agente de iARN de MAPT. En la presente descripción también se proporcionan métodos para usar los agentes de iARN de MAPT o composiciones que comprenden un agente de iARN de MAPT para reducir la expresión de MAPT y/o tratar una tauopatía en un sujeto.

Подробнее
25-07-2024 дата публикации

Modified oligonucleotides

Номер: WO2024123646A3
Принадлежит: ELI LILLY AND COMPANY

Aspects of the disclosure relate to compositions and methods for modulating levels, function, and/or activity one or more RNA transcripts (e.g., mRNA transcripts) or the proteins in a cell or subject. The disclosure is based, in part, on chemically modified inhibitory nucleic acids that are capable of target RNA knockdown with high specificity and low off-target effects.

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17-07-2024 дата публикации

Agentes de interferencia de arn de mapt

Номер: PE20241479A1
Принадлежит: Lilly Co Eli

Referido a un agente de interferencia de ARN (iARN) de MAPT que tiene una cadena codificante y una cadena no codificante, en donde la cadena codificante y la cadena no codificante forman un hibrido, en donde la cadena codificante y la cadena no codificante comprenden un par de secuencias de acido nucleico seleccionadas del grupo que consiste en: (a) la cadena codificante comprende una primera secuencia de acido nucleico que tiene al menos 95 % de identidad de secuencia con la SEQ ID NO: 15, y la cadena no codificante comprende una segunda secuencia de acido nucleico que tiene al menos 95 % de identidad de secuencia con la SEQ ID NO: 16; (b) la cadena codificante comprende una primera secuencia de acido nucleico que tiene al menos 95 % de identidad de secuencia con la SEQ ID NO: 1, y la cadena no codificante comprende una segunda secuencia de acido nucleico que tiene al menos 95 % de identidad de secuencia con la SEQ ID NO: 2; entre otros; en donde opcionalmente uno o mas nucleotidos de la cadena codificante y la cadena no codificante son nucleotidos modificados independientemente, y en donde opcionalmente uno o mas enlaces internucleotidicos de la cadena codificante y la cadena no codificante son enlaces internucleotidicos modificados. Tambien se refiere a una composicion farmaceutica que comprende el agente de iARN de MAPT para reducir la expresion de MAPT y/o tratar una tauopatia.

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31-07-2024 дата публикации

Agentes de interferencia de arn de mapt

Номер: ECSP24045476A
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de iARN de MAPT y composiciones que comprenden un agente de iARN de MAPT. En la presente descripción también se proporcionan métodos para usar los agentes de iARN de MAPT o composiciones que comprenden un agente de iARN de MAPT para reducir la expresión de MAPT y/o tratar una tauopatía en un sujeto.

Подробнее
21-09-2023 дата публикации

Sarm1 rna interference agents

Номер: WO2023177972A1
Принадлежит: ELI LILLY AND COMPANY

Provided herein are SARM1 RNAi agents and compositions comprising a SARM1 RNAi agent. Also provided herein are methods of using the SARM1 RNAi agents or compositions comprising a SARM1 RNAi agent for reducing SARM1 expression, reducing axon degeneration, and/or treating SARM1-mediated neurological disease in a subject.

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12-06-2024 дата публикации

Agentes de interferencia de arn de sarm1

Номер: AR128784A1
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de ARNi de SARM1 y composiciones que comprenden un agente de ARNi de SARM1. También se proporcionan en este documento métodos para usar los agentes de ARNi de SARM1 o composiciones que comprenden un agente de ARNi de SARM1 para reducir la expresión de SARM1, reducir la degeneración de axones y/o tratar enfermedades neurológicas mediadas por SARM1 en un sujeto.

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18-01-2024 дата публикации

Terapeutica con arn novedosos y usos de estos.

Номер: MX2024000085A
Принадлежит: Lilly Co Eli

La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8.

Подробнее
24-06-2024 дата публикации

Agentes de interferencia de arn de mapt.

Номер: MX2024007056A
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de iARN de MAPT y composiciones que comprenden un agente de iARN de MAPT. En la presente descripción también se proporcionan métodos para usar los agentes de iARN de MAPT o composiciones que comprenden un agente de iARN de MAPT para reducir la expresión de MAPT y/o tratar una tauopatía en un sujeto.

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25-04-2024 дата публикации

Terapeútica con arn novedosos y usos de estos

Номер: CR20230615A
Принадлежит: Lilly Co Eli

La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8.

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22-07-2024 дата публикации

Agentes de interferencia de arn de mapt

Номер: CR20240237A
Принадлежит: Lilly Co Eli

En la presente descripción se proporcionan agentes de iARN de MAPT y composiciones que comprenden un agente de iARN de MAPT. En la presente descripción también se proporcionan métodos para usar los agentes de iARN de MAPT o composiciones que comprenden un agente de iARN de MAPT para reducir la expresión de MAPT y/o tratar una tauopatía en un sujeto.

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24-10-2024 дата публикации

Sarm1 rna interference agents.

Номер: AU2023236166A1
Принадлежит: Eli Lilly and Co

Provided herein are SARM1 RNAi agents and compositions comprising a SARM1 RNAi agent. Also provided herein are methods of using the SARM1 RNAi agents or compositions comprising a SARM1 RNAi agent for reducing SARM1 expression, reducing axon degeneration, and/or treating SARM1-mediated neurological disease in a subject.

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