Biological adhesive microsphere with nuclear shell structure and preparation method of microsphere

The invention relates to a biological adhesive microsphere with a nuclear shell double-layer structure and a preparation method of the microsphere. By taking Zujin pill total alkaloids as a model medicine, taking natural high-molecular polymers such as chitosan, sodium alga acid and gelatin as carrier materials, an intelligent hydrogel medicine release system with biological adhesiveness is constructed. Due to the biological adhesive microsphere with the nuclear shell structure, detention time of the medicine in stomach is prolonged, medicine absorption is increased, and the biological availability of oral medicine for treating gastrohelcosis is improved. The biological adhesive microsphere is a reasonable and effective novel dosage form of gastrohelcosis-resisting medicine developed by using ancient prescription into a modern research method. The invention further illuminates in-vitro medicine release performance of the microsphere and in-vitro biological adhesion effect of the microsphere ...

High-voltage resistant casting copper alloy

The present invention is one kind of high pressure cast copper alloy, and belongs to the field of non-ferrous metal material technology. The alloy has the chemical composition of ZCuSn3Zn8Pb6Ni1 added with Fe and Co, and consists of Sn 2.0-4.0 wt%, Zn 6.0-9.0 wt%, Pb 4.0-7.0 wt%, Ni 0.5-2.5 wt%, Fe 0.1-7.0 wt%, Co 0.5-7.0 wt% and Cu for the rest. Its smelting and casting process includes the following steps: feeding electrolytic copper or returned copper material, Pb and Sn into the furnace, adding protective cover and heating, adding Fe, Co and Ni after reaching 1200 deg.c, adding Zn after reaching 1250 deg.c and maintaining for0.5 hr, maintaining at 1250 deg.c for one other 10-15 min, skimming and casting at 1200 deg.c, cooling the casting to room temperature, heating to 800-1000 deg.c and maintaining of 3-5 hr, and water cooling and solid solution treatment. The cast copper alloy has refined crystal grain structure and high tensile strength.

Connecting method of variable cross-section phononic crystal elastic material

The invention belongs to the field of functional materials and particularly provides a connecting method of a variable cross-section phononic crystal elastic material. The connecting method is characterized in that the variable cross-section phononic crystal elastic material consists of a copper block and a rubber column, the copper block and the rubber column are firstly bonded by using glue, then a copper pressure piece is added, and a bolt is further used for fixation, wherein the thickness of the copper pressure piece is 0.5mm-1mm, the outer diameter is 0.2mm smaller than a groove of the copper block, and the inner diameter is 0.2mm bigger than the rubber column. The connecting method adopts the glue bonding and simultaneously utilizes the pressure piece and the bolt to strengthen the bonding strength. Therefore, the bonding strength in the material is far larger than that of the traditional glue bonding method, thereby leading a phononic crystal to be capable of being applied in a ...

High-voltage resistant casting copper alloy and its manufacture method

Nanometer-temperature-sensitive assembled gel for nasal delivery, preparation method and application of nanometer-temperature-sensitive assembled gel

The invention discloses nano-temperature-sensitive assembled gel for nasal delivery, a preparation method and application of the nano-temperature-sensitive assembled gel, namely mitochondrial targeted puerarin nanoparticles and temperature-sensitive gel, and a preparation method and application of the mitochondrial targeted puerarin nanoparticles and the temperature-sensitive gel. According to the nano-temperature-sensitive assembled gel for nasal delivery, chitosan modified by SS-31 peptide with mitochondrial targeting and transmembrane characteristics is used as a carrier material, puerarin-loaded nanoparticles are prepared from chitosan modified by reactive oxygen species (ROS)-sensitive thioketal cross-linking agent in a cross-linking manner, and puerarin-loaded nanoparticles are prepared through a poloxamer temperature-sensitive gel system. According to the application of the nanoparticle-entrapped temperature-sensitive nanogel drug reservoir in preparation of drugs for treating nervous ...

High-strength high-elasticity Cu-Ni-Mn alloy and its preparation method

The invention relates to a high-strength high-elasticity Cu-Ni-Mn alloy and its preparation method. The alloy mainly comprises 46-73wt% of Cu, 13-26wt% of Ni, 13-26wt% of Mn, 0.5-1.0wt% of Zr, and 0.5-1.0wt% of Co, wherein a ratio of Ni to Mn is 0.8-1.2. The refinement of age-precipitated phases, the improvement of the distribution of the age-precipitated phases and reduction of discontinuous precipitated phases on a crystal boundary are realized by adding Zr, Co and other microalloy elements and controlling the Ni/Mn ratio in a range of 0.8-1.2 in order to obtain the high-strength high-elasticity Cu-Ni-Mn alloy. The yield strength, the tensile strength and the elastic modulus of the alloy are 1000-1200MPa, 1100-1500MPa and 132-140GPa respectively.

Output transmission for efficiently and smoothly operated electric actuator

The present invention belongs to motors transmission field and relates to an output transmission for efficiently and smoothly operated electric actuator. The output transmission is composed of four parts: output shaft (1), upper bearing (2), worm wheel (3) and lower thrust bearing (4) connected from top to bottom in sequence, and the upper bearing (2) together with the lower thrust bearing (4) forms dual pivots. The design of the dual pivots provides the output shaft with balanced and stable force, and reduces friction between the output shaft and the lower case body that improves transmission efficiency and prolongs service life of members.

Aligning sliding bearing for efficient air valve of subway

The invention belongs to the field of machine parts, and relates to an aligning sliding bearing for an efficient air valve of a subway. The aligning sliding bearing comprises a bearing block body (1), a sliding bearing (2), a bolt hole (3), a demounting hole (4) and an oil hole (5), wherein the bearing block body is fixed with an air valve framework by bolts; the sliding bearing is connected witha blade shaft; the demounting hole is arranged in a square shape along the radial direction of an inner hole of a bearing block; and a position which is in the radial direction of the inner hole of the bearing block and is vertical to the length direction of the bearing block is provided with the oil hole. The spherical contact surface of the sliding bearing is matched with the spherical contact surface on the bearing block, so a sliding ball is difficult to slide off in the bearing block and runs more stably, and the spherical surface assembling mode can automatically adjust the concentricity of ...

Accumulative roll bonding and heat treatment method for improving stress relaxation resistance of copper alloy

The invention relates to an accumulative roll bonding and heat treatment method for improving the stress relaxation resistance of a copper alloy. The method adopting a solid solution treated elastic copper alloy sheet with the thickness of 1-5mm as a raw material comprises the following steps: 1, stitching the surfaces of two cleaned copper alloy sheets together, and welding and bonding the peripheries of the stitched sheets; 2, putting the welded two copper alloy sheets in an argon or hydrogen protected heating furnace, heating to 800-880DEG C, carrying out heat insulation for 0.5h, and carrying out air cooling to room temperature; 3, carrying out one pass rolling deformation until the press quantity is 50%; 4, carrying out 2-8 time circular roll bonding operation by repeating step 1-3 to prepare a 4-256 layer copper alloy sheet with the thickness of 1-5mm, or carrying out cold rolling deformation until the pass deformation is 30-60% to prepare the copper alloy sheet with the thickness ...

High-strength and overpressure resistant casting copper alloy

The invention belongs to the nonferrous metal filed, in particular to a high strength pressureproof casting copper alloy, the grain structure of which is thinned. The invention is characterized in that based on chemical components of ZCuSn10Zn2 alloy regulated in technical conditions of the casting copper alloy in the National Standard GB1176-1987, iron and cobalt are added, and contents of other alloy elements are unchanged; compared with the developed pinetree structure of the cast structure of the ZCuSn10Zn2 tin bronze without adding iron and cobalt, crystal grains of the high strength pressureproof casting copper alloy are obviously thinned, and the average size of the crystal grains is approximately 40 to 100 mu m; the thinned grain structure facilitates the improvement of strength of materials, the achievement of the excellent plasticity and the improvement of the compactness and the pressureproof performance of the alloy; moreover, the copper alloy has the tensile strength obviously ...

Magnetized platelet drug delivery system and preparation method and application thereof

The invention discloses a magnetized platelet drug delivery system, a preparation method and application. The magnetized platelet drug delivery system comprises platelets, magnetic nanoparticles and drug nanoparticles, the magnetic nanoparticles and the drug nanoparticles are encapsulated in the cytoplasm of the blood platelets. According to the magnetized platelet drug delivery system disclosed by the invention, the platelet is utilized to load the magnetic nanoparticles, so that the magnetized platelet drug delivery system has good magnetic migration capability, tumor targeted delivery of the magnetized platelet is realized under the tumor trend of the platelet and the guidance of an external magnetic field, and the concentration of the drug delivery system at a focus part is improved; the magnetized platelet-loaded microenvironment active oxygen and photo-thermal dual response drug nanoparticles avoid premature release of the drug, reduce toxic and side effects of the drug, improve drug ...

Preparation of nano dispersed phase reinforced copper alloy

The invention relates to a preparation method of a nanometer dispersion phase strengthening copper alloy, which belongs to the field of nonferrous metals, in particular relates to the preparation method of the nanometer dispersion phase strengthening copper alloy. The method is characterized in that strengthening elements are added into the copper alloy, and then measures that can increase the forced convection, such as centrifuging, electromagnetic stirring, mechanical stirring or vibrating are taken to decrease the temperature gradient caused by the releasing of the latent heat from the precipitated phase crystal around the precipitated phase, so that the growth rate of the precipitated phase is decreased and the growth of the precipitated phase is restricted; the strengthening elements that are added into the copper alloy can be chosen one or more from Ti, Co, P, Ni, Mg, Cr, Zr, Be and Fe, the adding amount of the strengthening elements is 0.1 percent to 15 percent of the weight of the ...

High-temperature gas damper

The invention relates to a high-temperature gas damper, which belongs to the filed of gas combustion. The damper is a necessary device used in the flue systems of a power plant, an incinerator, a blast furnace and the like, aiming at the regulation of gas volume, the pressure control in a combustion system and the personnel safety of personnel maintaining various devices connected with air channels. The structural design of the damper is characterized in that a damper blade is connected with a rack-structured vane framework; a geometrical rack structure made according to transformation rule ofmaterials is reasonably jointed and reinforced with a vane blade, thus effectively solving the transformation problem due to heat expansion; expansion and contraction deviations of damper vanes and r ack-structured vane framework are equalized, thus ensuring the minimum malformed transformation due to transformation differences of different parts; and the cooled vanes has uniform transformation and ...

High-strength B10 cupronickel alloy material resistant to S2-environmental seawater corrosion and preparation method of high-strength B10 cupronickel alloy material

The invention discloses a high-strength B10 cupronickel alloy material resistant to S2-environment seawater corrosion. The high-strength B10 cupronickel alloy material comprises, by mass, 9.5%-10.5% of nickel, 1.2%-2.0% of iron, 0.4%-1.2% of manganese, 0.1%-2.0% of aluminum and the balance copper. The preparation method comprises the following steps: 1, preparing materials: taking T2 pure copper, pure nickel, Cu-40Fe intermediate alloy, pure manganese and pure aluminum according to a mass ratio; 2, smelting: putting the materials in a crucible, putting the crucible in the center of a high-frequency induction coil, firstly vacuumizing a furnace body, then introducing argon, repeating twice, heating to 1200-1300 DEG C, preserving heat for 5-10 minutes, cooling to 1050-1080 DEG C after metal is completely melted, and casting and molding in a casting mold; the mechanical property of the prepared B10 cupronickel alloy material is higher than that of a traditional B10 alloy and the S2-seawater ...

Aligning sliding bearing for efficient air valve of subway

The invention belongs to the field of machine parts, and relates to an aligning sliding bearing for an efficient air valve of a subway. The aligning sliding bearing comprises a bearing block body (1),a sliding bearing (2), a bolt hole (3), a demounting hole (4) and an oil hole (5), wherein the bearing block body is fixed with an air valve framework by bolts; the sliding bearing is connected witha blade shaft; the demounting hole is arranged in a square shape along the radial direction of an inner hole of a bearing block; and a position which is in the radial direction of the inner hole of the bearing block and is vertical to the length direction of the bearing block is provided with the oil hole. The spherical contact surface of the sliding bearing is matched with the spherical contact surface on the bearing block, so a sliding ball is difficult to slide off in the bearing block and runs more stably, and the spherical surface assembling mode can automatically adjust the concentricityof ...

Damping copper alloy material and preparation method thereof

The damping copper alloy material comprises the following components in percentage by mass: 1.0-6.0% of iron; 0.5 to 6.5 percent of nickel; 40%-70% of manganese; 0.5 to 6.5 percent of aluminum; the copper alloy comprises the following components in percentage by weight: 0.5 to 3.5 percent of zinc, 0.5 to 1.5 percent of phosphorus and the balance of copper and inevitable The preparation method comprises the following steps: preparing materials (pure Cu, Cu-Fe intermediate alloy, pure nickel, pure zinc and pure manganese), melting, preserving heat, cooling, melting Cu-P intermediate alloy and pure aluminum, preserving heat and casting and molding. By adding strengthening elements such as iron, phosphorus, nickel and the like, high strength and high elongation of the material are maintained, excellent damping vibration attenuation effect can be maintained, and the material is suitable for vibration attenuation components in the fields of machinery, equipment, spaceflight, traffic and the like ...

Development method of phonon crystal vibration reduction initial frequency of which is not higher than 200 Hz

The invention relates to a vibration reducing and sound insulating material, in particular to a development method of a phonon crystal the vibration reduction initial frequency of which is not higher than 200 Hz. The invention comprises the following steps. Metal material with 10e10 elastic modulus magnitude order and large density and rubber material with 10e6 elastic modulus magnitude order are chosen. The period size of the phonon crystal is 0.04m according to the stability condition. According to a transfer matrix method, equivalent density is obtained through calculation. The equivalent density method is adopted and when the vibration reduction initial frequency is lower than 200Hz, the height ratio the metal material and the rubber material is approximate to 1 to 1. The sectional areas of the metal material and the rubber material are calculated. The metal material and the rubber material are spliced periodically and then the phonon crystal the vibration reduction frequency of which ...

Application of tetrandrine in preparation of drug for prevention and/or treatment of depression

The invention discloses novel application of tetrandrine in preparation of a drug for prevention, alleviation and/or treatment of depression. A result of a test shows that tetrandrine has obvious anti-depression curative effects, can produce effects fast and has few toxic and side effects, and thus is a safe, efficient and stable anti-depression drug of which a preparation process is simple. Therefore, tetrandrine is suitable for industrialized production and is easy to be popularized. The invention provides a novel drug source for prevention and treatment of depression and its concurrent diseases, disorder or illnesses.