USE OF L-CITRULLINE IN MEDICINE ORTHOMOLECULAIRE FOR LAVASOPROTECTION, TONICITY RELAXATIF OF THE SMOOTH MUSCLES AND PROTECTION CELLULAR

Method and Apparatus for Obtaining Aromatics from Diverse Feedstock

The process relates to the use of any naphtha-range stream containing a portion of C8+ aromatics combined with benzene, toluene, and other non-aromatics in the same boiling range to produce toluene. By feeding the A8+ containing stream to a dealkylation/transalkylation/cracking reactor to increase the concentration of toluene in the stream, a more suitable feedstock for the methylation reaction can be produced. This stream can be obtained from a variety of sources, including the pygas stream from a steam cracker, “cat naphtha” from a fluid catalytic cracker, or the heavier portion of reformate.

ACETABULAR CUP ASSEMBLY FOR MULTIPLE BEARING MATERIALS

A modular acetabular cup assembly () for use with multiple bearing liners () is disclosed. The acetabular cup assembly includes a shell () having a tapered inner wall () and two circumferential grooves (). The shell () may be used with polyethylene, ceramic, metal, and other types of liners. 123-. (canceled)24. An acetabular cup assembly , comprising:a. a shell, the shell having a generally concave inner surface, an outer surface, a face, and an apex, said inner surface further comprising a first groove, a second groove, and a protrusion, the protrusion located between the first groove and the second groove, the second groove being closer to the apex of said generally concave inner surface; andb. a liner adapted to fit within said inner surface of said shell, the liner comprising an inner portion and a generally convex outer portion, said outer portion including a first bump and a second bump, said second bump being closer to the apex of said generally convex outer surface; andc. wherein a central axis extends through the apex, a line extends from where the inner surface meets the lower groove to where the central axis meets a planar surface defined by a plane extending through the face of the shell, the central axis and the line defining an angle, and wherein the angle ranges from about ten degrees to about eighty degrees.2538. The acetabular cup assembly according to claim , wherein the liner is selected from the group consisting of cross-linked polyethylene and conventional polyethylene.2638. The acetabular cup assembly of claim , wherein the liner includes anti-rotation tabs and the shell includes at least one scallop.2738. The acetabular cup assembly of claim , wherein the shell includes an insertion tool hole.2838. The acetabular cup assembly of claim wherein the inner surface of the shell is highly polished.2938. The acetabular cup assembly of claim , further comprising an inner wall with a taper.3038. The acetabular cup assembly of claim , wherein the liner ...

Methods and compositions for targeting treg cells

The antibody NEO-201 is shown to bind to Treg cells, and its use in targeting Treg cells is described. NEO-201 may be used for isolation, detection, or purification of active Treg cells and also to kill Treg cells. Therapeutic methods and combination therapies using NEO-201 optionally in combination with another agent are described.

ACETABULAR CUP ASSEMBLY FOR MULTIPLE BEARING MATERIALS

A modular acetabular cup assembly for use with multiple bearing liners is disclosed. The acetabular cup assembly includes a shell having a tapered inner wall and two circumferential grooves. The shell may be used with polyethylene, ceramic, metal, and other types of liners. 123.-. (canceled)24. An acetabular cup system , comprising:a shell having a generally concave inner surface, an outer surface, an end face formed at an upper end of the shell, an apex formed at a lower end of the shell, and a central axis extending through the apex, wherein the inner surface comprises an inwardly-facing scallop positioned adjacent the end face, an upper wall defining a taper with respect to the central axis and extending below the scallop, a lower wall located below the upper wall, a protrusion located below the lower wall, and a lower groove located below the protrusion;a first liner comprising generally convex first outer portion, the first outer portion including an outwardly-extending tab and a lower hump, wherein the first liner is formed of a polymer material; anda second liner comprising a generally convex second outer portion, the second outer portion including a tapered outer wall, wherein the second liner is formed of a metallic material;wherein the shell is configured to receive each of the first liner and the second liner;wherein when the first liner is seated in the shell, the tab is received in the scallop, the lower bump is received in the lower groove and engaged with a lower side of the protrusion, and an interference fit is formed between the first liner and the shell, the interference fit including at least engagement of the lower bump with the lower groove; andwherein when the second liner is seated in the shell, the tapered outer wall is engaged with the upper wall of the shell, and the second liner is retained in the shell by engagement between the tapered outer wall and the upper wall.25. The system of claim 24 , further comprising a third liner including a ...

Spreader roller for additive manufacturing

In one example, a temperature control system for a spreader roller in an additive manufacturing machine includes: a first duct to carry air to an air passage through the roller; a second duct to carry air away from the air passage through the roller; a fan to move air through the ducts; a temperature sensor to sense a temperature of the roller; and a controller to control a flow of air through the ducts based on a temperature sensed by the sensor.

Mixing powdered build material for additive manufacturing

In one example, a group of interchangeable supply modules to hold powdered build material for additive manufacturing. Each supply module in the group includes an exterior sized and shaped to fit into a mixer; an interior defining a non-circular mixing chamber, and an outlet through which powdered build material may leave the mixing chamber.

Steerable laser probe

A steerable laser probe may include a handle having a handle distal end and a handle proximal end, an actuation control of the handle, a housing tube having a housing tube distal end and a housing tube proximal end, a first housing tube portion having a first stiffness, a second housing tube portion having a second stiffness, an optic fiber disposed within an inner portion of the handle and the housing tube, and a cable disposed within the housing tube and the actuation control. A rotation of the actuation control may be configured to gradually curve the housing tube and the optic fiber. A rotation of the actuation control may be configured to gradually straighten the housing tube and the optic fiber.

ACETABULAR CUP ASSEMBLY FOR MULTIPLE BEARING MATERIALS

A modular acetabular cup assembly () for use with multiple bearing liners () is disclosed. The acetabular cup assembly includes a shell () having a tapered inner wall () and two circumferential grooves (). The shell () may be used with polyethylene, ceramic, metal, and other types of liners. 1. An acetabular cup assembly comprising:a. a shell, the shell having an inner surface and an outer surface, said inner surface further comprising a first groove, a second groove, and a tapered inner wall;b. a liner adapted to fit within said inner surface of said shell;c. wherein the liner is selected from the group consisting of a polymer liner, a ceramic liner, and a metal liner; andd. wherein the polyethylene liner comprises an inner portion and an outer portion, said outer portion including a first bump and a second bump, the ceramic liner further comprises a band, and the metal liner further comprising a tapered outer portion.2. The acetabular cup assembly according to claim 1 , wherein the polymer liner is selected from the group consisting of cross-linked polyethylene and conventional polyethylene.32. The acetabular cup assembly of any of - claims 1 , wherein the liner includes anti-rotation tabs and the shell includes at least one scallop.43. The acetabular cup assembly of any of - claims 1 , wherein the shell includes an insertion tool hole.54. The acetabular cup assembly of any of - claims 1 , wherein the inner surface of the shell is highly polished.65. The acetabular cup assembly of any of - claims 1 , wherein the shell is made from a material selected from the group consisting of titanium claims 1 , cobalt chromium claims 1 , and stainless steel.76. The acetabular cup assembly of any of - claims 1 , wherein the shell further comprises at least one fixation hole.87. The acetabular cup assembly of any of - claims 1 , wherein the shell further comprises a porous coating on said outer surface.98. The acetabular cup assembly of any of - claims 1 , wherein said band has ...

Compositions and methods comprising 2-(acylamino)imidazoles

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

Peptide-based inhibitors of growth hormone action and methods of use thereof

Compositions and methods for the inhibiting human growth hormone (hGH), and treating or preventing hGH-mediated disorders, using a S1H peptide having the amino acid sequence of [SEQ ID NO: 1], or a variant thereof, are described.

Build material recovery for a three-dimensional (3d) printer

A build material recovery system for a three-dimensional (3D) printer can include a selective solidification device to create a 3D object using build material, a build processing device to separate the 3D object from unfused build material, a material separating and conditioning device to condition the unfused build material, and a material storage device to store the conditioned build material.

Tire having a conductivity path

A tire includes a body ply sheet having a rubber core defined by a top surface having a length and a width, a bottom surface having substantially the same length and width, and side surfaces having a common height. The rubber core is further defined by a top rubber layer and a bottom rubber layer. The body ply sheet includes reinforcement cords disposed between the top rubber layer and the bottom rubber layer. The reinforcement cords are spaced 0.1-4.0 mm apart from each other and span the width of the body ply sheet. Bleeder cords are disposed on the body ply sheet and spaced 8-12 cm apart from each other. Conductive cords are also disposed on the body ply and spaced 20-80 cm apart from each other.

Different mixtures of build materials deliverable during a three dimensional print operation

Example implementations relate to different mixtures of build materials deliverable during a three dimensional (3D) print operation. In some examples, a 3D print apparatus may include a delivery hopper to deliver build material to a print zone of the 3D print apparatus and a plurality of build material hoppers to which the delivery hopper is connected for receipt of at least one of a corresponding plurality of build materials. A controller of the 3D print apparatus may direct that variable proportions of a first build material relative to a second build material are receivable by the delivery hopper from the plurality of build material hoppers during the 3D print operation, where different mixtures of the variable proportions of the first build material and the second build material are deliverable to the delivery hopper during the 3D print operation.

De-agglomerating sieve with de-ionization

A device to de-ionize a build material, a method to de-ionize, and a 3D printer system including the device are disclosed. The device includes a housing having an outlet port and an enclosed sieve within the housing. An inlet port is coupled to a first end the enclosed sieve to provide the build material. A drive actuator is coupled to a second end of the enclosed sieve. The housing and the enclosed sieve may be made of a polymer selected from the build material and a chemically-similar polymer to the build material.

Removal of excess build material in additive manufacturing

A three-dimensional (3D) printer and method of additive manufacture are disclosed. The method includes building a three-dimensional (3D) object via a 3D printing process. After the 3D printing process, the 3D object is contained within a cake comprising the 3D object and partially fused excess build material. The method further includes vibrating the cake to loosen the excess build material. The frequency of the vibration is swept across a predetermined range of frequencies over a predetermined sweep interval.

Sorghum maternal haploid inducing lines smhi01 and smhi02

Two sorghum maternal haploid inducer lines SMHI01 and SMHI02 are provided including seed, plants and plant parts thereof. Methods for producing sorghum haploid embryos using SMHI01 and SMHI02 are also provided. The sorghum haploid embryos produced as a result of the use of either maternal haploid inducer line SMHI01 or SMHI02 may be doubled to produce doubled haploid embryos, seeds, and plants as part of a sorghum breeding program.

Chimeric peptides for antisense deliver

Provided herein are oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates described herein.

Tire puncture feedback system

The present disclosure is directed to a smart tire puncture feedback system having a camera capable of observing foreign objects embedded in a tire, a proximity sensor, and a processor that can determine how long a foreign object has been embedded in the tire and alert a user after a predetermined period.

Bicyclic peptide oligonucleotide conjugates

Provided herein are oligonucleotides, bicyclic peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

Valves for air flow control in printers

An example three-dimensional printer includes a humidity source, a build material reservoir, a conduit between the humidity source and the build material reservoir, an air source to transfer air from the humidity source through the conduit towards the build material reservoir, and a valve assembly connected to the conduit to control a flow of the air in the conduit while the printer enters an inactive mode of operation. The air source is to remain in an active mode of operation. The air source is controlled to transmit the air in the conduit until the air in the conduit adjacent to the build material reservoir reaches a temperature and relative humidity threshold.

Filamentous organism-derived carbon-based materials, and methods of making and using same

The invention provides filamentous organism-derived carbonaceous materials doped with organic and/or inorganic compounds, and methods of making the same. In certain embodiments, these carbonaceous materials are used as electrodes in solid state batteries and/or lithium-ion batteries. In another aspect, these carbonaceous materials are used as a catalyst, catalyst support, adsorbent, filter and/or other carbon-based material or adsorbent. In yet another aspect, the invention provides battery devices incorporating the carbonaceous electrode materials.

ACETABULAR CUP ASSEMBLY FOR MULTIPLE BEARING MATERIALS

A modular acetabular cup assembly for use with multiple bearing liners is disclosed. The acetabular cup assembly includes a shell having a tapered inner wall and two circumferential grooves. The shell may be used with polyethylene, ceramic, metal, and other types of liners. 1. An acetabular cup system , comprising:a shell having a generally concave inner surface, an outer surface, an end face formed at an upper end of the shell, an apex formed at a lower end of the shell, and a central axis extending through the apex, wherein the inner surface comprises an inwardly-facing scallop positioned adjacent the end face, an upper wall defining a taper with respect to the central axis and extending below the scallop, a lower wall located below the upper wall, a protrusion located below the lower wall, and a lower groove located below the protrusion;a first liner comprising generally convex first outer portion, the first outer portion including an outwardly-extending tab and a lower hump, wherein the first liner is formed of a polymer material; anda second liner comprising a generally convex second outer portion, the second outer portion including a tapered outer wall, wherein the second liner is formed of a metallic material;wherein the shell is configured to receive each of the first liner and the second liner;wherein when the first liner is seated in the shell, the tab is received in the scallop, the lower bump is received in the lower groove and engaged with a lower side of the protrusion, and an interference fit is formed between the first liner and the shell, the interference fit including at least engagement of the lower bump with the lower groove; andwherein when the second liner is seated in the shell, the tapered outer wall is engaged with the upper wall of the shell, and the second liner is retained in the shell by engagement between the tapered outer wall and the upper wall.2. The system of claim 1 , further comprising a third liner including a generally convex ...

Printer ink supply system

An ink supply station for use with a first ink supply and a second ink supply includes a first module and a second module releasably coupled to the first module. The first module includes a first chassis and a first movable member supported by the chassis, wherein movement of the member causes flow of ink from the first ink supply. The second module includes a second chassis and a second movable member supported by the second chassis. Movement of the second member causes flow of ink from the second ink supply.

Method and apparatus for obtaining aromatics from diverse feedstock

The process relates to the use of any naphtha-range stream containing a portion of C8+ aromatics combined with benzene, toluene, and other non-aromatics in the same boiling range to produce toluene. By feeding the A8+ containing stream to a dealkylation/transalkylation/cracking reactor to increase the concentration of toluene in the stream, a more suitable feedstock for the methylation reaction can be produced. This stream can be obtained from a variety of sources, including the pygas stream from a steam cracker, "cat naphtha" from a fluid catalytic cracker, or the heavier portion of reformate.

Foam compositions comprising polylactic acid polymer, polyvinyl acetate polymer and plasticizer, articles, and methods of making and using same

Foam compositions are provided including a polylactic acid polymer; second (e.g., polyvinyl acetate) polymer having a glass transition temperature (T g ) of at least 25° C.; and plasticizer. Also described are articles comprising the foam compositions, such as a sheet or hearing protection article. Methods of making and using the foam compositions are further described herein.

Method and apparatus for biometric authentication

A biometric authentication method and system may be implemented in a client server architecture to provide substantial access control security and ease of administration. Users are enrolled in the system by providing multiple biometric measurements which are stored in a database as part of the user's biometric profile. Upon attempted access of a computer, the biometric authentication engine determines which biometrics are required and what the biometric matching criteria are based on the location of the computer, time of day and other security conditions. If the user is determined not to be authentic, a security policy may cause an action to occur such as revoking the user's access privileges or causing the login attempt to appear to be successful while the authorities are summoned.

Anti-factor d antibodies and conjugates

The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

Binding molecules for the treatment of cancer

This invention relates to binding molecules that bind specifically to CD137 and FAP and their use in medicine, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Agonistic trkb binding molecules for the treatment of eye diseases

The invention relates to agonistic TrkB binding molecules, methods for improving agonistic TrkB binders, their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Anti-factor D antibodies

The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Anti-factor D antibody variant conjugates and uses thereof

The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Anti-factor D antibody variant conjugates and uses thereof

The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Anti-factor D antibodies and conjugates

The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

Binding molecules for the treatment of cancer

This invention relates to binding molecules that bind specifically to CD137 and FAP and their use in medicine, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Retention Wire For Self-Expanding Stent

A delivery system for self-expanding stents is provided. The delivery system includes a wire releasably attached to a portion of the self-expanding stent. The wire restrains movement of the stent when the stent is released from the delivery system. Thus, more accurate placement of the stent may be possible.

Retention wire for self-expanding stent

A delivery system for self-expanding stents is provided. The delivery system includes a wire releasably attached to a portion of the self-expanding stent. The wire restrains movement of the stent when the stent is released from the delivery system. Thus, more accurate placement of the stent may be possible.

Multi-specific binding proteins for cancer treatment

The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Bispecific anti-vegf and anti-trkb binding molecules for the treatment of eye diseases

This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Extrahepatic delivery

One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.

Cyclic-disulfide modified phosphate based oligonucleotide prodrugs

This invention relates to a compound comprising a structure of formula (I): cyclic disulfide moiety — phosphorus coupling group (I). The cyclic disulfide moiety has the structure of (C-I), (C-II), or (C-III). This invention also relates to an oligonucleotide comprising one or more compounds that comprise the structure of formula (I), wherein at least one phosphorus coupling group contains a nucleoside or oligonucleotide. The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein.

System and method for managing presence based on relationship

A system and method for managing presence information based on a specified presence level between a user and other parties. An interface is provided that allows a user to specify a presence level between the user and one or more other parties. Once a user specifies a presence level, the specified level dictates how an incoming communication request is to be managed in the event that the user is not available to receive the communication. The specified presence level may determine the amount of information disclosed to the other party, the presence that is projected to the other party, and the decision on whether to interrupt the user. In some embodiments, the presence level between the user and other parties is automatically inferred by a relationship engine.

Relationship-based processing

A relationship engine provides for the management of relationship information between entities. The relationship information indicates the level (or degree) of relationship between an entity and another entity or entities. The relationship engine allows applications to access the relationship information that is being managed by the relationship engine. For example, when an application needs to process an interaction between one entity and another entity, the application can query the relationship engine for the relationship between the entities. The application can then base its processing behavior at least in part on the relationship information obtained from the relationship engine.

Managing presence based on relationship

A system and method for managing presence information based on a specified presence level between a user and other parties. An interface is provided that allows a user to specify a presence level between the user and one or more other parties. Once a user specifies a presence level, the specified level dictates how an incoming communication request is to be managed in the event that the user is not available to receive the communication. The specified presence level may determine the amount of information disclosed to the other party, the presence that is projected to the other party, and the decision on whether to interrupt the user. In some embodiments, the presence level between the user and other parties is automatically inferred by a relationship engine.

Relationship-based processing

A relationship engine provides for the management of relationship information between entities. The relationship information indicates the level (or degree) of relationship between an entity and another entity or entities. The relationship engine allows applications to access the relationship information that is being managed by the relationship engine. For example, when an application needs to process an interaction between one entity and another entity, the application can query the relationship engine for the relationship between the entities. The application can then base its processing behavior at least in part on the relationship information obtained from the relationship engine.

Patient healthcare record templates

A system for automatically expediting charting for an emergency medical services event includes databases with a pre-configured ePCR form including fillable fields and a first and a second ePCR template, the first and second templates specifying pre-determined values for first and second fillable field subsets and a computing device, configured to communicatively couple to the databases, that includes a user interface, a memory, and a processor configured to receive a request to generate an ePCR, access the pre-configured ePCR form, receive selections of the first and second ePCR templates, automatically populate at least portions of the fillable fields based on the templates by identifying non-overlapping fields and overlapping fields in the subsets of fillable fields, populating the non-overlapping fields with the pre-determined values, and populating the overlapping fields with the pre-determined values according to selection rules, and generate the ePCR based on the automatic population of the fillable fields.

Improved pressure sensitive adhesive compositions

The present disclosure generally relates to adhesive compositions, adhesive articles including the adhesive compositions, methods of making the adhesive compositions and articles, and methods of using the adhesive compositions and articles. The adhesive compositions of the present disclosure include a thermoplastic phenolic resin made from the reaction of (1) alkyl phenol (e.g., butyl- or octyl- or -nonyl) and formaldehyde; or (2) alkyl phenol

Improved pressure sensitive adhesive compositions

The present disclosure generally relates to adhesive compositions, adhesive articles including the adhesive compositions, methods of making the adhesive compositions and articles, and methods of using the adhesive compositions and articles. The adhesive compositions of the present disclosure include a thermoplastic phenolic resin made from the reaction of (1) alkyl phenol (e.g., butyl- or octyl- or -nonyl) and formaldehyde; or (2) alkyl phenol (e.g., butyl- or octyl-) and acetaldehyde; or (3) alkyl phenol (e.g., butyl- or octyl-) and acetylene. The present disclosure also generally relates to adhesive articles including these adhesive compositions. The inventors of the present disclosure found that such adhesive articles exhibit excellent adhesion to architectural coatings with including low or no VOCs, deep base formulations, and/or formulations including primer in various conditions, including, for example, high humidity.

Systems and methods for providing nonlinear journaling

In one embodiment, systems and methods are provided for nonlinear journaling. In one embodiment, groups of data designated for storage in a data storage unit are journaled into persistent storage. In one embodiment, the journal data is recorded nonlinearly. In one embodiment, a linked data structure records data and data descriptors in persistent storage.

Electrically controlled racing game with information and control center

A system for racing an electrically powered toy vehicle over a defined course under operator control comprises a continuous track having at least one lane (24, 26) with a pit stop segment (39) and an electrical path (30, 32) extending along the lane for providing electrical power to the vehicle. A control unit (18, 20) is operably connected to the electrical path and has at least a first manual control mechanism (96, 108) used to vary a speed of the electrical vehicle and another (97, 98) to perform at least either a tire change or a vehicle refueling pit stop function. A display unit (16), operably connected to the control unit via a microprocessor (54), displays a progression of the pit stop function in response to actuations of the other control mechanism. The display further includes a changing animated display area (154) as well as other dedicated display areas (156, 158, 160, 162, 164, 166).

High shear swirler with recessed fuel filmer for a gas turbine engine

An assembly is provided for a turbine engine. This assembly includes a swirler and a fuel nozzle. The swirler is configured with an outer wall, an inner wall, an outer passage and an inner passage. The outer wall circumscribes the inner wall and extends axially along an axis to a distal outer wall end. The inner wall extends axially along the axis to a distal inner wall end that is axially recessed within the swirler from the distal outer wall end. The outer passage is formed by and radially between the inner wall and the outer wall. The inner passage is formed by and radially within the inner wall. The fuel nozzle projects into the inner passage. The fuel nozzle is configured with a plurality of orifices axially aligned with the inner wall and arranged circumferentially about the axis.

Inhalation system and method

A system includes but is not limited to at least one manifold; an inhalant dissemination device coupled to the at least one manifold; an inhalant characterization device coupled to the at least one manifold; and a control module operably coupled to the inhalant dissemination device and the inhalant characterization device, said control module configured to (a) determine an inhalant concentration in a manifold, and (b) calculate at least one of a retrospective and a prospective inhaled dose in response to the inhalant concentration, and (c) start and stop a flow through the manifold until the at least one of the retrospective and the prospective inhaled dose is greater than or equal to a specified dose. A method includes but is not limited to starting a flow of an inhalant through a manifold; determining an inhalant concentration of the inhalant in the manifold; and stopping the flow of the inhalant through the manifold when the inhalant concentration is in a first specified inhalant-concentration range.

Systems and methods for providing nonlinear journaling

In one embodiment, systems and methods are provided for nonlinear journaling. In one embodiment, groups of data designated for storage in a data storage unit are journaled into persistent storage. In one embodiment, the journal data is recorded nonlinearly. In one embodiment, a linked data structure records data and data descriptors in persistent storage.

Liquid containing and dispensing device

Binding molecules for the treatment of cancer

This invention relates to binding molecules that bind specifically to CD137 and FAP and their use in medicine, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Printhead priming

Printhead priming can, in various examples, employ a conduit and a divider such that a predetermined portion of a pressurized gas in the conduit is provided to an environment surrounding the divider and a remaining portion of the pressurized gas in the conduit is provided to a printhead at a pressure sufficient to prime an ink supply.

Extrahepatic delivery

One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.

Anti-factor d antibody variants and uses thereof

The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Bispecific anti-vegf and anti-trkb binding molecules for the treatment of eye diseases

This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Golf club set providing improved distance gapping adjustability

A set of golf clubs having a degree of adjustability to provide improved distance gapping across the transition from a curved face golf club head to a flat face golf club head.

Automated inhalation toxicology exposure system

Amusement ride with rider-selected integrated audio

A personalized audio system for an amusement ride includes an audio selection system, a guest identification system and a ride vehicle enabled to reproduce audio selections made using the selection system in a specific seat of the ride vehicle corresponding to the seat occupied by the guest who selected the audio during that guest's ride on the amusement ride.

A method for determining total iron in aqueous solutions

A composition and an assay solution for the determination of dissolved iron concentration comprising an α-diimine compound and a reducing agent are described. The α-diimine compound acts as a colorimetric iron sensor. The α-diimine compound coordinates to ferrous ions in solution to give a colored diimine-iron complex. The absorbance of the resulting diimine-iron solution is measured and is a function of the analyte's iron concentration. The iron concentration of a solution can be determined by treating the solution with the present composition, measuring the absorbance, and comparing the absorbance to the absorbance of assay standards of known concentration.

Venous infusion catheter and methods for its use

A venous infusion catheter includes an elongated and hollow body defining an internal cavity and extending longitudinally between a proximal open end and a distal end, the elongated and hollow body being provided with a lateral port, the proximal open end being fluidly connectable to a source of fluid to be delivered; and an external balloon secured to an external face of the elongated and hollow body, the lateral port being located between the external balloon and the proximal end of the elongated and hollow body, the external balloon being modifiable between an inflated configuration and a deflated configuration, and the external balloon being fluidly connectable to a source of inflation fluid for inflating the external balloon.

Dynamic speed control for pump motor

Systems and methods of controlling the speed of a pump configured to move liquid through a pump system are described. The actual motor speed of the pump motor is controlled by adjusting a current applied to the motor based on the difference between the actual motor speed and the target motor speed according to a gain setting. A first gain value is applied as the gain setting when the difference between the actual motor speed and the target motor speed does not exceed a first threshold. However, a second, higher gain value is applied when the difference between the actual motor speed and the target motor speed exceeds the first threshold.

Tire tread

Systems and methods of quota accounting

Embodiments of the invention relate generally to incremental computing. Specifically, embodiments of the invention include systems and methods that provide for the concurrent processing of multiple, incremental changes to a data value while at the same time monitoring and/or enforcing threshold values for that data value. For example, a method is provided that implements domain quotas within a data storage system.

Parallelogram arm vehicle lift

A lift for transferring a user to and from a vehicle, the lift including a lift platform for receiving the user, the lift platform being arcuately movable between a first position and a second position; a vertical arm coupled to the lift platform, the vertical arm having a profile that is progressively convex along the entire length of the vertical arm; and a pair of parallel arms extending from the vertical arm, wherein each of the parallel arms is pivotally coupled to a bracket mounted to the vehicle; wherein the vertical arm has a generally U-shaped cross-section that forms a channel configured to receive at least a portion of the pair of parallel arms.

Removal of excess build material in additive manufacturing

A three-dimensional (3D) printer and method of additive manufacture are disclosed. The method includes building a three-dimensional (3D) object via a 3D printing process. After the 3D printing process, the 3D object is contained within a cake comprising the 3D object and partially fused excess build material. The method further includes vibrating the cake to loosen the excess build material. The frequency of the vibration is swept across a predetermined range of frequencies over a predetermined sweep interval.

Tire puncture feedback system

The present disclosure is directed to a smart tire puncture feedback system having a camera capable of observing foreign objects embedded in a tire, a proximity sensor, and a processor that can determine how long a foreign object has been embedded in the tire and alert a user after a predetermined period.

Fuel injector assembly

An assembly is provided for a turbine engine. This assembly includes a swirler (64) and a fuel nozzle (154). The swirler (64) is configured with an outer wall (80), an inner wall (82), an outer passage (86) and an inner passage (84). The outer wall (80) circumscribes the inner wall (82) and extends axially along an axis (70) to a distal outer wall end (138). The inner wall (82) extends axially along the axis (70) to a distal inner wall end (118) that is axially recessed within the swirler (64) from the distal outer wall end (138). The outer passage (86) is formed by and radially between the inner wall (82) and the outer wall (80). The inner passage (84) is formed by and radially within the inner wall (82). The fuel nozzle (154) projects into the inner passage (84). The fuel nozzle (154) is configured with a plurality of orifices (158) axially aligned with the inner wall (82) and arranged circumferentially about the axis (70).

Bivalent bromodomain inhibitors and uses thereof

The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Low power portable ultrasonic diagnostic instrument

A portable ultrasonic diagnostic instrument including an array transducer (1 ), a beam former (3), signal processing, imaging circuitry (4), and a display ( 5) for the processed echo signals operates on no more than 25 watts of electric al power. Circuit functions can be select attend depending on mode of operation of the instrument to thereby reduce power consumption. Further, a power monitor and control (6) can monitor electrical current from a battery power source. When power consumption reaches a predetermined level the power monit or and control further alters one or more functional units in the instrument including display mode of operation, clock frequency for analog to digital conversion, signal processing, color signal processing, and 3D signal processing. Power consumption can be monitored against two or more predetermined levels wherein instrument functional units or mode of operatio n are altered depending on which level of power consumption has been reached. In an instrument with an analog beam former, power consumption can be limited t o 10 watts, whereas in a digital beam former instrument power consumption can be limited to no more than 25 watts.

Bivalent bromodomain inhibtors and uses thereof

The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BDl and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Systems and methods for providing nonlinear journaling

In one embodiment, systems and methods are provided for nonlinear journaling. In one embodiment, groups of data designated for storage in a data storage unit are journaled into persistent storage. In one embodiment, the journal data is recorded nonlinearly. In one embodiment, a linked data structure records data and data descriptors in persistent storage.

Acetabular cup set for multiple support materials

Un conjunto de copa acetabular (10, 100, 200, 300) que comprende: a. una carcasa (12), la carcasa tiene una superficie interior (14) y una superficie exterior, dicha superficieinterior comprende además un primer surco (24), y una pared interior estrechada (28); b. un forro (32, 110, 212, 310, 354) adaptado para encajar dentro de dicha superficie interior (14) de dichacarcasa; c. en donde el forro (32, 110, 212, 310, 354) es un forro de polímero, un forro cerámico o un forro de metal; y d. en donde el forro de polímero comprende una parte interior y una parte exterior (216), dicha parte exteriorincluye un primer bulto (34) caracterizado porque la superficie interior (14) de la carcasa comprende además un segundo surco (26), y la parteexterior incluye un segundo bulto (36) y el forro cerámico comprende además una banda (112), y el forro de metalcomprende además una parte exterior estrechada (216). An acetabular cup assembly (10, 100, 200, 300) comprising: a. a carcass (12), the carcass has an inner surface (14) and an outer surface, said inner surface further comprises a first groove (24), and a narrowed inner wall (28); b. a liner (32, 110, 212, 310, 354) adapted to fit within said inner surface (14) of said housing; C. wherein the lining (32, 110, 212, 310, 354) is a polymer lining, a ceramic lining or a metal lining; and d. wherein the polymer lining comprises an inner part and an outer part (216), said outer part includes a first bulge (34) characterized in that the inner surface (14) of the housing further comprises a second groove (26), and the outer part it includes a second package (36) and the ceramic lining further comprises a band (112), and the metal lining further comprises a narrowed outer part (216).

Extracting 3d objects

Automated inhalation toxicology exposure system

A method to exposing an animal to an inhalant; acquiring near real time measurement of at least respiration during said exposing; and calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing. The method further includes to automatically controlling an environment of an inhalant chamber; automatically controlling a concentration of an inhalant in the inhalant chamber, and displaying near real time measurement data related to an animal in an inhalant chamber.

Multi-specific binding proteins for cancer treatment

The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Tire puncture feedback system

The present disclosure is directed to a smart tire puncture feedback system having a camera capable of observing foreign objects embedded in a tire, a proximity sensor, and a processor that can determine how long a foreign object has been embedded in the tire and alert a user after a predetermined period.

Extracting 3d objects

In an example implementation, a method of extracting three-dimensional (3D) objects includes forming on a vibratory extraction platform, a build cake comprising a fused 3D object encased within build material and vibrating the extraction platform to break apart the build material and sift it through openings in the extraction platform.

Air-cooled electric machine and method of assembling the same

An electric machine comprises a motor housing and an electronics enclosure coupled to the motor housing. The electronics enclosure defines an air passage between the electronics enclosure and the motor housing. The electronics enclosure further defines at least one air intake connected to said air passage. The electric machine also includes a fan configured to draw air through the at least one air intake and into the air passage.

Build material extraction using vibration and airflow

In one example in accordance with the present disclosure, an additive manufacturing platform is described. The additive manufacturing platform includes a vibrating bed on which a volume of build material is to be disposed. The bed is to vibrate to remove excess build material and operates in at least two extraction modes during a build material extraction period. The additive manufacturing platform also includes a non-vibrating frame to support the vibrating bed.

Automated Inhalation Toxicology Exposure System

Three-dimensional printer

A three-dimensional (3D) printer includes a selective solidification module to selectively solidify portions of successive layers of a build material on a build platform. The 3D printer also includes a cartridge receiver to hold a removable material cartridge that accepts material from the 3D printer and makes material available to the 3D printer for printing of the 3D object.

Mixing powdered build material for additive manufacturing

In one example, a build material supply system for additive manufacturing includes a mixer to aperiodically rotate a non-circular mixing chamber containing powdered build material to form mixed powdered build material.

Cooling of build material in three dimensional printing system

Automated inhalation toxicology exposure system

A system includes but is not limited to at least one manifold; an inhalant dissemination device coupled to the at least one manifold; an inhalant characterization device coupled to the at least one manifold; and a control module operably coupled to the inhalant dissemination device and the inhalant characterization device, said control module configured to (a) determine an inhalant concentration in a manifold and (b) calculate at least one of a retrospective and a prospective inhaled dose in response to the inhalant concentration, and (c) start and stop a flow through the manifold until the at least one of the retrospective and the prospective inhaled dose is greater than or equal to a specified dose. A method includes but is not limited to starting a flow of an inhalant through a manifold; determining an inhalant concentration of the inhalant in the manifold; and stopping the flow of the inhalant through the manifold when the inhalant concentration is in a first specified inhalant-concentration range.

Acetabular cup assembly for multiple bearing materials

A modular acetabular cup assembly (10, 100, 200, 300, 350) for use with multiple bearing liners (32, 110, 212, 310, 354) is disclosed. The acetabular cup assembly includes a shell (12) having a tapered inner wall (28) and two circumferential grooves (24, 26). The shell (12) may be used with polyethylene, ceramic, metal, and other types of liners.

Display for immersive window effect

Mixing powdered build material for additive manufacturing

In one example, a group of interchangeable supply modules to hold powdered build material for additive manufacturing. Each supply module in the group includes an exterior sized and shaped to fit into a mixer; an interior defining a non-circular mixing chamber, and an outlet through which powdered build material may leave the mixing chamber.

Multi-specific binding proteins for cancer treatment

The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Toy vehicle

A toy vehicle (10) has front and rear chassis portions (100, 200) and a flipping mechanism (400) which allows the front chassis portion to rotate 36 0 degrees with respect to the rear chassis portion about a longitudinal axis (434). The flipping mechanism includes a triggering mechanism (410), a rotational drive mechanism (430) and a mechanism (460) to prevent damage to a main spring (440) which drives the rotational motion of the front chassis relative to the rear chassis. The toy vehicle may be remote controlled, and include a remote control transmitter (500). One remote control transmitter includes a left hand (510) and a right hand portion (520), with the two portions being pivotable with respect to one another to activate a control switch (540).

Off-axis printhead assembly attachable to a carriage

An off-axis printhead assembly includes a printhead body that has an engagement element removably attachable to an attachment mechanism of a carriage of a printing system, the attachment mechanism of the carriage removably attachable to an on-axis printhead assembly. A fluid conduit interconnect is removably attached to the printhead body, the fluid conduit interconnect to connect to a fluid conduit to communicate printing fluid from at least one off-axis printing fluid supply through the fluid conduit interconnect to the printhead body.

Acetabular cup assembly for multiple bearing materials

Electrically controlled racing game with information and control center

A system for racing an electrically powered toy vehicle over a defined course under operator control comprises a continuous track having at least one lane (24, 26) with a pit stop segment (39) and an electrical path (30, 32) extending along the lane for providing electrical power to the vehicle. A control unit (18, 20) is operably connected to the electrical path and has at least a first manual control mechanism (96, 108) used to vary a speed of the electrical vehicle and another (97, 98) to perform at least either a tire change or a vehicle refueling pit stop function. A display unit (16), operably connected to the control unit via a microprocessor (54), displays a progression of the pit stop function in response to actuations of the other control mechanism. The display further includes a changing animated display area (154) as well as other dedicated display areas (156, 158, 160, 162, 164, 166).

Mounting device

Examples of a mounting device and method are disclosed herein. An example of the mounting device includes a carriage to hold a printhead assembly and an interconnect assembly to supply printing composition to the printhead assembly. The mounting device also includes a first latching assembly having an engaged condition to lock the interconnect assembly to a manifold of the printhead assembly and a disengaged condition to unlock the interconnect assembly from the manifold of the printhead assembly. The mounting device additionally includes a second latching assembly having an engaged condition to lock the printhead assembly to the carriage and a disengaged condition to unlock the printhead assembly from the carriage. In this example of the mounting device, the second latching assembly cannot be moved from the engaged condition to the disengaged condition unless the fast latching assembly is in the disengaged condition.

System and method for sensing harvested crop levels within an agricultural harvester

A system for sensing harvested crop levels within an agricultural harvester may include a crop tank configured to receive harvested crop. The system may further include a sensor configured to emit a sensor beam into the crop tank for reflection off of the top surface of the harvested crop. Additionally, the system may include a reflection panel positioned at a minimum detectable crop level within the crop tank. The reflection panel may be configured to reflect the sensor beam when the current crop level is vertically below the minimum detectable crop level. A center of the reflection panel may be positioned closer to the sensor than an outer edge of the reflection panel such that the reflection panel diffuses the sensor beam as it reflects off of the reflection panel.

Fried pizza product and process for preparing same

A fried pizza crust and a complete pizza product are produced with a method in which perforations are formed in a pizza dough sheet by removing small plugs of dough. Each perforated dough piece is then submerged in a hot oil bath until the crust is fried. The fried crust is removed from the oil and drained, after which it is topped with sauce. The sauce flows into funnel shaped depressions formed over each perforation, some of the sauce flowing through the perforations before congealing. Other topping materials are then applied to the sauce covered crust. The finally topped pizza includes small pools of sauce and flavor enhanced crust areas.

Systems and methods for providing nonlinear journaling

In one embodiment, systems and methods are provided for nonlinear journaling. In one embodiment, groups of data designated for storage in a data storage unit are journaled into persistent storage. In one embodiment, the journal data is recorded nonlinearly. In one embodiment, a linked data structure records data and data descriptors in persistent storage.

Inhalant system

In one embodiment, a method includes but is not limited to: conditioning an inhalant environment; exposing a first organism to the inhalant environment for a first-organism duration of time; and exposing a second organism to the inhalant environment for a second-organism duration of time. In one embodiment, a method includes but is not limited to: conditioning an inhalant environment; exposing a first organism to the inhalant environment until a calculated first-organism delivered dosage meets or exceeds a predefined first-organism target dosage; and exposing a second organism to the inhalant environment until a calculated second-organism delivered dosage meets or exceeds a predefined second-organism target dosage. In one embodiment, a method includes but is not limited to: detecting a first organism via a first-organism biochip device implanted in the first organism; and controlling a first-organism dosage in response to the first-organism biochip device. In addition to the foregoing, other method embodiments are described in the claims, drawings, and text forming a part of the present application. In one or more various embodiments, related systems include but are not limited to circuitry and/or programming for effecting the foregoing-referenced method embodiments; the circuitry and/or programming can be virtually any combination of hardware, software, and/or firmware configured to effect the foregoing- referenced method embodiments depending upon the design choices of the system designer. In one embodiment, a system includes but is not limited to: an inhalant manifold; a first independently-controllable exposure unit coupled to said inhalant manifold; a second independently-controllable exposure unit coupled to said inhalant manifold; and an exposure control system operably coupled to either or both said first independently-controllable exposure unit and said second independently-controllable exposure unit.