Packet-based mobile network

A telecommunications system uses a packet switched network to provide communications capabilities to mobile devices. Base transceiver stations (BTSs) on the network communicate with mobile devices in their respective coverage areas. User media exchanged between the mobile devices and the BTSs are encoded in the mobile devices' native formats. The BTSs encapsulate the user media in a packet-based representation and send it to the other endpoint of the session via the network. A media gateway interfaces with telephone networks and converts media between the native formats of the mobile devices and the native formats of the telephone networks. A softswitch provides session processing and media connection signaling and switching via control signals encoded in a packet-based representation and sent to the BTSs and/or media gateways via the packet switched network.

METHODS AND APPARATUS FOR ADJUSTING BLOOD CIRCULATION

Embodiments of the invention include a method and a device for increasing blood flow and controlling the temperature of a mammal by applying a desired pressure to extremities of a mammal. The device generally includes a pliant body element that is adapted to receive a portion of an extremity of the mammal therein, and then apply a pressure to a portion of the extremity when a pressure is provided to a region in which the extremity is positioned within the pliant body element. By evacuating the region in which the extremity is enclosed, a contact surface area between the extremity of a mammal and the pliant body element is increased, due to the external atmospheric pressure acting on the pliant body element against the skin of the extremity of the mammal. The application of pressure assures that sufficient contact and thermal heat transfer (heating or cooling) is provided to the extremity of the mammal.

METHODS AND APPARATUS FOR ADJUSTING BLOOD CIRCULATION

Embodiments of the invention include a method and a device for increasing blood flow and controlling the temperature of a mammal by applying a desired pressure to extremities of a mammal. The device generally includes a pliant body element that is adapted to receive a portion of an extremity of the mammal therein, and then apply a pressure to a portion of the extremity when a pressure is provided to a region in which the extremity is positioned within the pliant body element. By evacuating the region in which the extremity is enclosed, a contact surface area between the extremity of a mammal and the pliant body element is increased, due to the external atmospheric pressure acting on the pliant body element against the skin of the extremity of the mammal. The application of pressure assures that sufficient contact and thermal heat transfer (heating or cooling) is provided to the extremity of the mammal. 1. A method of preventing and/or reducing a risk of deep vein thrombosis (DVT) in an appendage of a mammal , comprising: one or more first flexible walls of the flexible body at least partially enclose the internal region, and', 'the flexible body defines an outermost surface of a portion of the device, and the portion of the device is configured to be disposed over a portion of the appendage of the mammal when the portion of the appendage is disposed within the internal region through an opening that is formed within flexible body, and, 'cyclically varying pressure within an internal region of a flexible body of a device, wherein'} (a) adjusting the pressure within the internal region to a first pressure level that is below atmospheric pressure, wherein the adjusted pressure causes the one or more first flexible walls to collapse against the portion of the appendage that is disposed within the internal region, and the flexible body is configured to substantially conform to the shape of the portion of the appendage when the first pressure level is achieved within the ...

Methods of Determining Patient Response by Measurement of HER-3

The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3. 1. A method of measuring and/or quantifying the presence and/or amount of Her-3 or Her-3 in a complex in a sample from a subject , the method comprising providing a sample and determining the presence and/or quantity of Her-3 and/or Her-3 in a complex in the sample using a Her-3 antibody that specifically binds to a polypeptide sequence set forth in one of SEQ ID NOs:1-8.2. The method of claim 1 , wherein the Her-3 antibody specifically binds to a polypeptide sequence set forth in SEQ ID NO:6.3. The method of claim 1 , wherein the Her-3 antibody is at least one of a monoclonal antibody comprising (a) a light chain variable region comprising CDR1 claim 1 , CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:13 claim 1 , 14 and 15 claim 1 , respectively claim 1 , and (b) a heavy chain variable region comprising CDR1 claim 1 , CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:16 claim 1 , 17 and 18 claim 1 , respectively; or a monoclonal antibody comprising (a) a light chain variable region comprising CDR1 claim 1 , CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:19 claim 1 , 20 and 21 claim 1 , respectively claim 1 , and (b) a heavy chain variable region comprising CDR1 claim 1 , CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:22 claim 1 , 23 and 24 claim 1 , respectively.4. The method of claim 1 , wherein the Her-3 antibody is at least one antibody comprising an amino acid sequence set forth in SEQ ID NOs:9 and 11 for the light and heavy chains claim 1 , respectively claim 1 , or SEQ ID NOs:10 and 12 as set forth in Table 1 for the light and heavy chains claim 1 , respectively.5. The method of claim 1 , wherein the method comprises mixing the sample with the Her-3 antibody and determining the presence and/or quantity of the Her-3 antibody ...

METHODS AND APPARATUS FOR ADJUSTING BLOOD CIRCULATION

Embodiments of the invention include methods and devices for increasing blood flow and controlling the temperature of a mammal. The device generally includes collapsible and pliant body elements, capable of expanding from a first volume into an expanded second volume so which can then be reduced from the expanded second volume into a pressurized third volume. One or more thermal exchange units can be positioned in the one or more collapsible and pliant body elements. Accordingly, the temperature of the extremity of a mammal can be regulated by providing heating or cooling to the one or more thermal exchange units. 1. A device for increasing blood flow and/or controlling body temperature in a mammal , comprising:a flexible body having one or more first flexible walls that enclose at least a portion of an internal region;an opening formed in the flexible body that is configured to receive an extremity of a mammal and allow a portion of the extremity to be positioned within the internal region;one or more second flexible walls sealably coupled to at least a portion of the one or more first flexible walls to form an enclosed fluid plenum region therebetween; anda first pump fluidly coupled to the internal region and configured to create a pressure below atmospheric pressure within the internal region to cause the one or more first flexible walls to collapse against the portion of the extremity disposed in the internal region.2. The device of claim 1 , wherein the one or more flexible walls are configured to conform to the shape of the portion of the extremity when the first pump creates a pressure below atmospheric pressure within the internal region.3. The device of claim 1 , wherein the one or more first flexible walls and the one or more second flexible walls comprise urethane claim 1 , polyurethane or poly(vinyl chloride) claim 1 , and the one or more second flexible walls are sealably coupled to the at least a portion of the one or more first flexible walls by RF ...

MONITORING GEOSPATIAL CONTEXT OF A MOBILE DEVICE

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions. 1. A computer-implemented method of assessing whether a mobile device is in a geospatial area , the method comprising:causing storage of a representation of a non-circular geospatial zone in a memory of the mobile device;determining, based at least in part on the geospatial zone, an outer circular boundary entirely encompassing the geospatial zone, wherein the outer circular boundary is defined by at least a centroid of the geospatial zone and a maximum radius;determining, based at least in part on the geospatial zone, an inner circular boundary entirely encompassed within the geospatial zone, wherein the inner circular boundary is defined by at least the centroid of the geospatial zone and a minimum radius;computing a current distance of the mobile device from the centroid of the geospatial zone; andin response to a determination that the computed current distance both exceeds the minimum radius and does not exceed the maximum radius, utilizing the geospatial zone to determine a context of the mobile device.2. The computer-implemented method of further comprising:computing an updated current distance of the mobile device from the centroid of the geospatial zone; andin response to a ...

MONITORING MOBILE DEVICE CONTEXT

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions. 1. A power-efficient method of assessing a context of a mobile device , the method comprising:maintaining state data indicative of a current context of a mobile device, wherein the state data defines whether the mobile device is available to establish communication with a third party device;determining, at the mobile device, a transition of the mobile device from the current context to an updated context, wherein the determination is based at least in part on information obtained by the mobile device during each interval of a set of intervals, wherein the obtained information is not transmitted from the mobile device, and wherein the set of intervals is based at least in part on an anticipated variance of the obtained information; modifying the state data based at least in part on the determined transition, wherein the state data is indicative of the updated context, and wherein modification of the state data occurs only in response to a determination of a transition, and', 'modifying, without interaction with an external device, the set of intervals based at least in part on the updated context, wherein the modified set of intervals are defined by the updated context and correspond to ...

Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis

The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans. 1. A method of separating and detecting nucleic acid fragments , comprising: wherein each set of the one or more sets of dye-labeled nucleic acid fragments produced from one or more samples is labeled with a plurality of spectrally resolvable fluorescent dyes and is produced from a different sample, and', 'wherein each set of dye-labeled nucleic acid fragments produced from a different sample is separated in a different separation channel;, 'separating one or more sets of dye-labeled nucleic acid fragments produced from one or more samples using an electrophoresis system comprising one or more separation channels,'} wherein each of the plurality of dyes is excited, and', 'wherein light emitted by each of the plurality of light sources is spatially separated from light emitted by any of the other light source(s) at any given time; and, 'exciting the plurality of spectrally resolvable fluorescent dyes in each ...

EFFICIENT DETECTION OF MOVEMENT USING SATELLITE POSITIONING SYSTEMS

The management of GPS sensor data in a mobile communication device. In one embodiment, a mobile device can implement a GPS sensor data sampling framework to minimize the number of GPS satellite fixes required to determine location or movement assessments. Additionally, in another embodiment, the mobile device can implement a heuristic-based processing routine to determine whether sampled GPS data is indicative of GPS signal reflections. 1. A computer-implemented method , comprising:collecting a set of positioning signals over a defined period of time, the set of positioning signals corresponding to a maximum number of positioning signals;processing the set of positioning signals; determining first velocity information based a current positioning signal;', 'determining second velocity information based on a calculation of velocity from two successive location coordinates;', 'performing a first determination regarding validity of the current positioning signal based, at least in part, on a comparison of the first velocity information and the second velocity information;, 'for each positioning signal in the set of positioning signals,'}performing an updating determination regarding validity of each positioning signal in the set of positioning signals based on a second comparison of the first and second velocity information for the set of positioning signals; andmodifying at least one positioning signal in the set of positioning signals based on the updated determination regarding validity of each positioning signal in the set of positioning signals.2. The computer-implemented method as recited in claim 1 , wherein the set of positioning signals correspond to global positioning system signals.3. The computer-implemented method as recited in claim 1 , wherein the maximum number of positioning signals in the set of positioning signals corresponds to three positioning signals.4. The computer-implemented method as recited in claim 1 , wherein processing the set of ...

MOBILE DEVICE CONTEXT INCORPORATING NEAR FIELD COMMUNICATIONS

A communication environment includes of one or more subscriber terminals capable of receiving and transmitting data over a communication network via a communication management system. The communication management system receives mobile communication device context information based on near-field sensor information and mobile communication device identification information from the mobile communication device. The communication management system then processes the mobile communication device profile. 1. A computer-implemented method , comprising:receiving context change notification messages transmitted by a mobile communications device, at least some of said context change notification messages based on context assessments performed by the mobile communications device based on interaction with one or more near-field sensors;maintaining state data in computer storage based, at least in part, on the received context change notification messages, wherein the state data is maintained and updated in said computer storage at least during time periods in which the mobile communications device is not being used by the user, said computer storage being separate from the mobile communications device;receiving updated context change notification messages corresponding to the mobile communications device, the updated context change notification messages transmitted by the mobile communications device solely when a change in context is determined based on interaction with additional near-field sensors;associating the mobile communications device with updated state data; anddetermining at least one of a direction or movement vector based on processing of the context change notification message and updated context change notification messages.2. The computer-implemented method as recited in claim 1 , wherein receiving updated context change notification messages corresponding to the mobile communications device includes receiving updated context change notification messages ...

Methods and apparatus for adjusting blood circulation

Embodiments of the invention include a method and a device for increasing blood flow and controlling the temperature of a mammal by applying a desired pressure to extremities of a mammal. The device generally includes a pliant body element that is adapted to receive a portion of an extremity of the mammal therein, and then apply a pressure to a portion of the extremity when a pressure is provided to a region in which the extremity is positioned within the pliant body element. By evacuating the region in which the extremity is enclosed, a contact surface area between the extremity of a mammal and the pliant body element is increased, due to the external atmospheric pressure acting on the pliant body element against the skin of the extremity of the mammal. The application of pressure assures that sufficient contact and thermal heat transfer (heating or cooling) is provided to the extremity of the mammal.

SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS

This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module. 1. A cartridge comprising:a first chamber containing a first solution that comprises one or more pairs of forward and reverse primers for amplifying one or more selected nucleotide sequences; anda second chamber containing a second solution that comprises a polymerase.2. The cartridge of claim 1 , wherein:the first chamber and the second chamber are part of a receptacle, or are separate receptacles, removably attached to the cartridge; orthe first chamber and the second chamber are contained in the cartridge.3. The cartridge of or claim 1 , further comprising a reaction chamber for nucleic acid amplification.4. A method of performing nucleic acid amplification claim 1 , comprising:delivering a polynucleotide to a reaction chamber;delivering a first solution comprising one or more pairs of forward and reverse primers for amplifying one or more selected nucleotide sequences from a first chamber to the reaction chamber;delivering a second solution comprising a polymerase from a second chamber to the reaction chamber; andamplifying the one or more selected nucleotide sequences of the polynucleotide;wherein ...

Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients

The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Methods of Determining Patient Response by Measurement of HER-3

The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3. 130-. (canceled)31. A method for quantifying Her-3 and p95 levels in a sample from a subject that has a cancer , comprising:(a) obtaining a sample from the subject's cancer;(b) measuring the amount of Her-3 and p95 in the sample using a Her-3 antibody that specifically binds to a polypeptide sequence set forth in one of SEQ ID NOs 6-8 and a p95 antibody that specifically binds to a p95 protein having a first amino acid corresponding to methionine 611 of HER2 protein; and(c) quantifying the amount of Her-3 and p95 in the subject's sample.32. The method of claim 31 , further comprising determining whether the amount of Her-3 and p95 in the subject's sample is above a Her-3 cutoff and whether the p95 in the subject's sample is above a p95 cutoff.33. The method of claim 32 , further comprising indicating that the subject is at least one of:(i) more likely to respond to a Her family targeted agent, more likely to have a long time course during treatment with a Her family targeted agent, and/or less likely to have a significant event during treatment with a Her family targeted agent if the amount of Her-3 and the amount of p95 are below the Her-3 cutoff and the p95 cutoff, respectively, as compared to if the amount of Her-3 is above the Her-3 cutoff, the amount of p95 is above the p95 cutoff, or the amount of Her-3 and the amount of p95 are above the Her-3 cutoff and the p95 cutoff, respectively;(ii) more likely to respond to a Her family targeted agent, more likely to have a long time course during treatment with a Her family targeted agent, and/or less likely to have a significant event during treatment with a Her family targeted agent if the amount of Her-3 is above the Her-3 cutoff and the amount of p95 is below the p95 cutoff, or the amount of Her-3 is below the Her-3 ...

RESTRICTING FUNCTIONALITY OF PROTECTED DEVICES

Systems, methods and interfaces are disclosed for restricting functionality of protected mobile communication devices. Protected mobile communication devices may generally include mobile communication devices that do not allow applications to directly restrict the mobile communication device's functionalities, such as call reception or access to a standard user interface. Specifically, a mobile application can monitor the context of the mobile communication device to determine whether the device is in one of three states: inactive; active and locked; or active and under the application's control. When the device enters the active and locked state, the mobile application can ensure that unlocking the device places the device under the application's control. Further, when the device is under the application's control, the mobile application can ensure that leaving the application's control places the device in a locked state. The device can therefore be restricted to functionality provided under these three states. 1. A computer-implemented method of restricting functionality on a protected mobile communication device , the method comprising:detecting set of conditions under which functionality of the protected mobile communication device is to be restricted;displaying a restricted interface on the protected mobile communication device, wherein the restricted interface at least partially limits functionality of the protected mobile communication device that is accessible to a user;detecting that the restricted interface is no longer a primary interface of the protected mobile communication device; and locking the protected mobile communication device; and', 'generating a notification on the protected mobile communication device associated with the restricted interface, wherein the protected mobile communication device is configured to, on unlocking by the user, display an interface associated with a most recently generated notification., 'in response to detecting that ...

Methods of Determining Patient Response by Measurement of HER-2 Expression

Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples, the probable time to progression can be determined by first determining HER2 positive patients and then further stratifying by using the presence or the absence of a second biomarker (e.g, HER3 markers). In addition, the data can be used to track a patient's response to a treatment regimen, assessing the expected success of treating a patient using a particular regiment, determining the effects of a treatment regiment or for categorizing a patient in order to create a homogenous group for a clinical trial. 1. A method to correlate the relative levels of the amount of at least one of Her-2 or Her-2 homodimers in a biological sample from a subject with a prognosis for the likelihood that the subject will respond to treatment with a Her-2 acting agent comprising:(a) detecting in a biological sample from the subject's cancer the amount of at least one of Her-2 or Her-2 homodimers; and(b) correlating the amount of Her-2 or Her-2 homodimers to a prognosis for the likelihood that the subject will respond to treatment with a Her-2 acting agent.2. The method of claim 1 , wherein the cancer is at least one of metastatic or primary early stage (i.e. claim 1 , adjuvant) breast cancer.3. The method of claim 1 , wherein if the amount of the at least one of the Her-2 or Her-2 homodimers is equal to or above a first threshold level claim 1 , the subject's prognosis is to be likely to respond to the Her-2 acting agent.4. The method of claim 1 , wherein if the amount of the at least one of the Her-2 or Her-2 homodimers is equal to or above a second threshold level higher than the first threshold level claim 1 , the subject's prognosis is to be unlikely to respond to the ...

CONTEXT-BASED MANAGEMENT OF MOBILE DEVICES

Systems, methods and interfaces are disclosed for managing communications associated with a mobile device. Mobile devices process environmental inputs and transmit context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. A management system uses the context information, optionally in combination with communication device profiles, to determine how to manage requests for communication with the mobile device. Mobile device users may also be inhibited from initiating communications. 1. A method comprising:determining, at a mobile device, a first context of the mobile device based at least in part on sensor data of the mobile device;generating, at the mobile device and prior to a requested communication session including the mobile device, a context notification message based at least in part on the determined first context, wherein management of the requested communication session by a remote call processing device is defined by the context notification message; andtransmitting the context notification message from the mobile device to the remote call processing device to enable the remote call processing device to process the requested communication session based on the management defined by the context notification message.2. The method of further comprising initiating claim 1 , at the mobile device claim 1 , the requested communication session subsequent to allowance of the requested communication session by the remote call processing device.3. The method of further comprising receiving claim 1 , at the mobile device claim 1 , a notification that the requested communication session has been disallowed by the remote call processing device based on the management defined by the context notification message.4. The method of further comprising:determining ...

BYPASSING ENHANCED SERVICES

A communication environment includes of one or more subscriber terminals capable of initiating emergency voice calls over a telephony network. The subscriber terminal further send messages over either a data network or a telephony signaling network to a communication management system. The communication management system receives messages from a subscriber terminal, either via a data network or a telephony signaling network. It also consists of one or more telephony switching nodes capable of querying the emergency context node for a called party emergency context. It also consists of one or more servers that provide advanced call control services. 1receiving a first context message identifying a first context state of a mobile device, wherein the first context state is one of a plurality of defined potential context states, each of the plurality of defined potential context states corresponding to a range of potential sensor information regarding an environment of the mobile device, and wherein an availability of the mobile device to establish communication is defined as a function of a previously received context state of the mobile device, independent of specific sensor information on which the previously received context state is based;independent of processing the specific sensor information on which the first context state is based, processing the first context state to determine that the availability of the mobile device corresponds to providing enhanced communication services to the mobile device, wherein the enhanced communication services disallow at least one request for communication including the mobile device;receiving a second context message identifying a second context state of the mobile device, wherein the second context state is one of the plurality of defined potential context states;independent of processing the specific sensor information on which the second context state is based, processing the second context state to determine that the ...

ENCODING CONTEXT WITHIN SERVICES DATA

Systems and methods are provided enabling context information, such as a current speed of travel, to be transmitted between a context source, such as a vehicle, and a mobile device. Illustratively, the mobile device may be configured to utilize context information to enforce context-based restrictions on the mobile device, such as to restrict non-emergency functionality of the device when travelling above a threshold speed. Specifically, embodiments of the present application enable context information to be encoded within service data, and transmitted to the mobile device without requiring an established connection (e.g., a “pairing”) between the mobile device and the context source. For example, specific context information may be encoded into a service identifier, and transmitted within a service record to the mobile device. The mobile device may then decode the context information from the service identifier to determine a context, e.g., for use in context-based policy enforcement. 1. A system for transmitting context information independent of an established communication channel , the system comprising:one or more sensors configured to determine information regarding a mobile device environment; and obtain sensor data from the one or more sensors;', 'determine, based at least in part on the sensor data, context information of the mobile device environment;', 'receive, from a mobile device within the mobile device environment, a request for service data, wherein the request for service data is transmitted independent of an established connection between the one or more processors and the mobile device, and in accordance with a protocol enabling the service data to reflect services available to the mobile device;', 'encode within generated service data the determined context information; and', 'transmit, independent of an established connection between the one or more processors and the mobile device, the encoded service data to the mobile device as a response ...

MANAGEMENT OF MOBILE DEVICE COMMUNICATION SESSIONS TO REDUCE USER DISTRACTION

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions. 1. A computer-implemented method , comprising:receiving a context message identifying a context state of a mobile device, wherein the identified context state is one of a plurality of defined potential context states, each of the plurality of defined potential context states corresponding to a range of potential sensor information regarding an environment of the mobile device, and wherein an availability of the mobile device to establish communication is defined as a function of a previously received mobile device context state independent of specific sensor information on which the context state is based;independent of processing the specific sensor information on which the context state is based, processing the received context message to determine the availability of the mobile device, wherein the availability is determined based at least in part on the identified context state;receiving a request for communication with the mobile device;determining whether to allow the request for communication based at least in part on the availability of the mobile device; andbased at least in part on a determination that the request for communication is allowed, establishing the communication ...

MOBILE DEVICE MANAGEMENT

Aspects of the present disclosure correspond to the utilization of criteria for distinguishing between temporary changes to mobile communication device movement state in determining whether a mobile communication device context has changed. A mobile communication device can be configured to manage one or more aspects of functionality of the mobile communication device based on a mobile communication device context. At some point, the mobile communication device can determine a transition to a substantially stationary state. Rather than immediately transitioning the mobile communication device context, the mobile communication device can define a period of time in which additional changes to the mobile communication device movement state can be detected. Accordingly, if the mobile communication device movement state transitions again to a non-stationary movement state within the guard period, the mobile communication device context remains in the non-stationary movement state and never transitions. 1. A computer-implemented method for managing content , comprising:associating a movement state context to a mobile device reflective of a determined movement state of the mobile device corresponding to a non-stationary state;subsequently determining a first modification of the determined movement state of the mobile device indicative of a transition of the movement state to a substantially stationary state, wherein the determination of the modification does not cause a modification of the movement state context;causing initiation of a first guard period to determine whether the movement state is further modified;determining a second modification of the determined movement state of the mobile device indicative of a transition of the movement state to a non-stationary state prior to expiration of the first guard period;subsequently determining a third modification of the determined movement state of the mobile device indicative of a transition of the movement state to a ...

Methods of Determining Patient Response by Measurement of HER-3

The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3. 130-. (canceled)31. A method for determining whether a subject with a HER2 positive cancer is likely to respond to treatment with a HER2 targeted agent , comprising:(a) obtaining a biological sample from of the subject's cancer;(b) measuring the amount of HER3 in the biological sample;(c) determining that the subject is more likely to respond to the HER2 targeted agent, more likely to have a long time course, less likely to have a significant event in the time course of disease during the treatment with the HER2 targeted agent if the amount of HER3 in the subject's sample is below a statistically significant HER3 cutoff, the HER3 cutoff having been determined by positional scanning analysis of a cohort of subjects having HER2 positive cancer of the same kind as the subject.321. The method of claim , wherein the cutoff is a median of HER3 levels in the cohort of subjects having HER2 positive cancer of the same kind as the subject.331. The method of claim , wherein measuring the amount of HER3 in the biological sample comprises measuring at least one of total HER3 protein , HER3 homodimers , or HER3 heterodimers.341. The method of claim , wherein measuring the amount of HER3 in the biological sample comprises using immunohistochemistry to quantitate the amount of HER3.351. The method of claim , wherein measuring the amount of HER3 in the biological sample comprises the steps of:a) contacting the biological sample with a HER3 antibody;b) contacting the HER3 antibody with a tagged binding composition, wherein the tagged binding composition comprises a molecular tag attached thereto via a cleavable linkage, and wherein the tagged binding composition specifically binds to the HER3 antibody;c) cleaving the cleavable linker of the tagged binding composition, thereby releasing the ...

Sample Preparation, Processing and Analysis Systems

This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module. 1. (canceled)2. A microfluidic device , comprising:a reaction chamber;a microfluidic channel in fluidic communication with the reaction chamber; and (i) a compartment;', '(ii) an exit port disposed at a bottom of the reagent vial;', '(iii) a first movable object that seals a top of the compartment opposite the exit port; and', '(iv) a second movable object that seals the exit port;', 'wherein the compartment the is configured to hold a fluid composition between the first movable object and the second movable object; and', 'wherein the reagent vial is configured such that force applied on the first movable object in the direction of the second moveable object actuates the second movable object to unseal the exit port, thereby providing a fluid flow path between the compartment and the microfluidic channel., 'a reagent vial connected to the microfluidic channel, the reagent vial comprising3. A system , comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'the microfluidic device of ; and'} a receptacle configured to receive the microfluidic device; and', 'an actuation device configured to apply a ...

Methods of Determining Patient Response by Measurement of HER-2 Expression

Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples, the probable time to progression can be determined by first determining HER2 positive patients and then further stratifying by using the presence or the absence of a second biomarker (e.g, HER3 markers). In addition, the data can be used to track a patient's response to a treatment regimen, assessing the expected success of treating a patient using a particular regiment, determining the effects of a treatment regiment or for categorizing a patient in order to create a homogenous group for a clinical trial. 1. A method to correlate the relative levels of the amount of at least one of Her-2 or Her-2 homodimers in a biological sample from a subject with a prognosis for the likelihood that the subject will respond to treatment with a Her-2 acting agent comprising:(a) detecting in a biological sample from the subject's cancer the amount of at least one of Her-2 or Her-2 homodimers; and(b) correlating the amount of Her-2 or Her-2 homodimers to a prognosis for the likelihood that the subject will respond to treatment with a Her-2 acting agent.2. The method of claim 1 , wherein the cancer is at least one of metastatic or primary early stage (i.e. claim 1 , adjuvant) breast cancer.3. The method of claim 1 , wherein if the amount of the at least one of the Her-2 or Her-2 homodimers is equal to or above a first threshold level claim 1 , the subject's prognosis is to be likely to respond to the Her-2 acting agent.4. The method of claim 1 , wherein if the amount of the at least one of the Her-2 or Her-2 homodimers is equal to or above a second threshold level higher than the first threshold level claim 1 , the subject's prognosis is to be unlikely to respond to the ...

Microfluidic method for nucleic acid purification and processing

Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid flows away from said main electrophoretic flowpath through a discharge outlet. The subject devices find use in a variety of electrophoretic applications, including clinical assays, high throughput screening for genomics and pharmaceutical applications, point-or-care in vitro diagnostics, molecular genetic analysis and nucleic acid diagnostics, cell separations, and bioresearch generally.

Sample preparation, processing and analysis systems

This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

Microfluidic method for nucleic acid purification and processing

Integrated microfluidic devices comprising at least an enrichment channel ( 10 ) and a main electrophoretic flowpath ( 12 ) are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid flows away from said main electrophoretic flowpath through a discharge outlet ( 6 ). The subject devices find use in a variety of electrophoretic applications, including clinical assays, high throughput screening for genomics and pharmaceutical applications, point-or-care in vitro diagnostics, molecular genetic analysis and nucleic acid diagnostics, cell separations, and bioresearch generally.

Bypassing enhanced services

A communication environment includes of one or more subscriber terminals capable of initiating emergency voice calls over a telephony network. The subscriber terminal further send messages over either a data network or a telephony signaling network to a communication management system. The communication management system receives messages from a subscriber terminal, either via a data network or a telephony signaling network. It also consists of one or more telephony switching nodes capable of querying the emergency context node for a called party emergency context. It also consists of one or more servers that provide advanced call control services.

Mobile device context incorporating near field communications

A communication environment includes of one or more subscriber terminals capable of receiving and transmitting data over a communication network via a communication management system. The communication management system receives mobile communication device context information based on near-field sensor information and mobile communication device identification information from the mobile communication device. The communication management system then processes the mobile communication device profile.

Apparatus for treating prostate cancer and method for same

A medical device for photodynamically treating cancerous tissue, such as prostate cancer, comprising a body, a needle extendable from the body and at least one light-emitting (e.g., laser) diode mounted on the needle. The body is sized and configured for introduction into the urethra of a patient. The needle is movable between a retracted position housed substantially within the cylindrical body, and a deployed position in which the needle extends from the cylindrical body to enable it to penetrate into prostate tissue. The light-emitting diode is adapted to emit light to activate a photosensitizing agent (e.g., porfimer sodium) in or adjacent cancerous tissue in the prostate. Methods of treating cancer and other embodiments of medical devices for cancer treatment are also disclosed.

Methods of determining patient response by measurement of HER-3

The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.

Integrated microfluidic devices

Integrated microfluidic devices comprising at least an enrichment channel (10) and a main electrophoretic flowpath (12) are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid flows away from said main electrophoretic flowpath through a discharge outlet (6). The subject devices find use in a variety of electrophoretic applications, including clinical assays, high throughput screening for genomics and pharmaceutical applications, point-or-care in vitro diagnostics, molecular genetic analysis and nucleic acid diagnostics, cell separations, and bioresearch generally.

Management of mobile device communication sessions to reduce user distraction

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions.

Packet-based mobile network

A telecommunications system uses a packet switched network to provide communications capabilities to mobile devices. Base transceiver stations (BTSs) on the network communicate with mobile devices in their respective coverage areas. User media exchanged between the mobile devices and the BTSs are encoded in the mobile devices' native formats. The BTSs encapsulate the user media in a packet-based representation and send it to the other endpoint of the session via the network. A media gateway interfaces with telephone networks and converts media between the native formats of the mobile devices and the native formats of the telephone networks. A softswitch provides session processing and media connection signaling and switching via control signals encoded in a packet-based representation and sent to the BTSs and/or media gateways via the packet switched network.

Methods of Determining Patient Response By Measurement of HER-2 Expression

Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples, the probable time to progression can be determined by first determining HER2 positive patients and then further stratifying by using the presence or the absence of a second biomarker (e.g, HER3 markers). In addition, the data can be used to track a patient's response to a treatment regimen, assessing the expected success of treating a patient using a particular regiment, determining the effects of a treatment regiment or for categorizing a patient in order to create a homogenous group for a clinical trial.

Restricting functionality of protected devices

Systems, methods and interfaces are disclosed for restricting functionality of protected mobile communication devices. Protected mobile communication devices may generally include mobile communication devices that do not allow applications to directly restrict the mobile communication device's functionalities, such as call reception or access to a standard user interface. Specifically, a mobile application can monitor the context of the mobile communication device to determine whether the device is in one of three states: inactive; active and locked; or active and under the application's control. When the device enters the active and locked state, the mobile application can ensure that unlocking the device places the device under the application's control. Further, when the device is under the application's control, the mobile application can ensure that leaving the application's control places the device in a locked state. The device can therefore be restricted to functionality provided under these three states.

Pack

A pack of tablets has a generally rigid body within which the tablets are retained. There is an elastomeric membrane (12) on one side of the tablets., formed with protuberances (14), and a frangible sheet on the other side of the tablets. The tablets may be in a blister unit, with the tablets in register with the protuberances, The protuberances are pressed to expel the tablets. Two packs , may be joined together by a hinge such that they can be folded against each other, for storage.

Restricting functionality of protected mobile devices

Systems, methods and interfaces are disclosed for restricting functionality of protected mobile communication devices. Protected mobile communication devices may generally include mobile communication devices that do not allow applications to directly restrict the mobile communication device's functionalities, such as call reception or access to a standard user interface. Specifically, a mobile application can monitor the context of the mobile communication device to determine whether the device is in one of three states: inactive; active and locked; or active and under the application's control. When the device enters the active and locked state, the mobile application can ensure that unlocking the device places the device under the application's control. Further, when the device is under the application's control, the mobile application can ensure that leaving the application's control places the device in a locked state. The device can therefore be restricted to functionality provided under these three states.

Folding bicycle

FOLDING BICYCLE ABSTRACT OF THE DISCLOSURE The folding bicycle which includes front and rear wheels and a sprocket and pedal assembly mounted to a frame and a steering column and a seat column mounted to such frame, is provided wherein the seat column and the steering fold into proximity with the frame and substantially in the plane of the frame, while the rear wheel and sprocket assembly pivot around the sprocket axis into proximity with the frame and the front wheel, also in the plane of such frame. The seat column has a bend or goose neck below the seat thereof to permit the seat column when folded toward the steering column, to curve around the base portion of the steering column and permit the steering column to fold thereover in planar proximity. Other features of the planar folding bicycle include foldable handle bars and foldable pedals and a sprocket belt drive which is positioned against the drive gear of the rear wheel by an adjustable nip guide roll. S P E C I F I C A T I O N

High speed loom

Providing and managing bypass of enhanced services

A communication environment includes of one or more subscriber terminals capable of initiating emergency voice calls over a telephony network. The subscriber terminal further send messages over either a data network or a telephony signaling network to a communication management system. The communication management system receives messages from a subscriber terminal, either via a data network or a telephony signaling network. It also consists of one or more telephony switching nodes capable of querying the emergency context node for a called party emergency context. It also consists of one or more servers that provide advanced call control services.

Management of mobile device communication sessions to reduce user distraction

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions.

Tandem isotachophoresis/zone electrophoresis method and system

A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing- edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected, in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charged sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separate by zone electrophoresis.

Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients

The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Management of mobile device communication sessions to reduce user distraction

Systems, methods and interfaces are disclosed for managing communications associated with a mobile communication device. Mobile communication devices process environmental inputs and transmit mobile communication device context information to a communication management system. The context information may, for example, reflect the motion and/or geographic location of the mobile device, and may reflect the risk associated with using the device to handle a call or other communications session. The communication management system uses the context information, optionally in combination with communication device profiles, to determine how to manage incoming and/or ongoing calls or other communication sessions. Mobile device users may also be inhibited from initiating communication sessions.

Apparatus for adjusting blood circulation

Efficient detection of movement using satellite positioning systems

The management of GPS sensor data in a mobile communication device. In one embodiment, a mobile device can implement a GPS sensor data sampling framework to minimize the number of GPS satellite fixes required to determine location or movement assessments. Additionally, in another embodiment, the mobile device can implement a heuristic-based processing routine to determine whether sampled GPS data is indicative of GPS signal reflections.

Mobile device management

Aspects of the present disclosure correspond to the utilization of criteria for distinguishing between temporary changes to mobile communication device movement state in determining whether a mobile communication device context has changed. A mobile communication device can be configured to manage one or more aspects of functionality of the mobile communication device based on a mobile communication device context. At some point, the mobile communication device can determine a transition to a substantially stationary state. Rather than immediately transitioning the mobile communication device context, the mobile communication device can define a period of time in which additional changes to the mobile communication device movement state can be detected. Accordingly, if the mobile communication device movement state transitions again to a non-stationary movement state within the guard period, the mobile communication device context remains in the non-stationary movement state and never transitions.

Improvements in drills orbits for rock-drilling

Verpackung

Improvements in quoits

Method and apparatus for controlling an electric powered assisted steering system using an adaptive blending torque filter

An apparatus and method for controlling an electric steering assist system, which system provides assist in response to a steering control signal, comprising: torque sensor (20) operatively connected to steering wheel (12) for providing a torque signal (Ts) blending filter means connected to the torque sensor for providing a blended filtered torque signal having a first functional characteristic at torque frequencies less than the blending frequency and a second functional characteristic at torque frequencies greater than the blending frequency, including a low pass filter (70) which passes all frequencies below the blending frequency and a high pass filter (71) providing said control signal to the steering assist means in response to the blended filtered torque signal whereby high frequency gain of the steering assist system is arranged to be low from on-centre operation of the hand wheel and relatively higher for off-centre operation.

Metodo y aparato para controlar un sistema electrico de direccion asistida que usa un filtro par de mezcla adaptativo.

Un aparato para controlar un sistema eléctrico de dirección asistida que ofrece asistencia como respuesta a una señal de control de dirección, comprendiendo el aparato: un medio sensor de par motor (20) conectado operativamente al volante de mano de un vehículo (12) para proporcionar una señal de par motor (Ts) indicativa del par motor de dirección aplicado, un medio de filtro de mezclado conectado al medio sensor de par motor (20) para proporcionar una señal de par motor filtrada y mezclada (Tm) que tiene una primera característica funcional a frecuencias de par motor inferiores a las de una frecuencia de mezclado y una segunda característica funcional a frecuencias de par motor superiores a la frecuencia de mezclado, el medio de filtro de mezclado incluyendo un filtro de paso bajo (150) en un circuito de frecuencia baja por el medio de filtro de mezclado, cuyo filtro de paso bajo deja pasar todas las frecuencias inferiores a la frecuencia de mezclado y un filtro de paso alto (152) en un circuito de frecuencia alta por el medio de filtro de mezclado, cuyo filtro de paso alto deja pasar todas las frecuencias superiores a la frecuencia de mezclado, un medio de dirección asistida (90 y 28) que proporciona dirección asistida al volante de mano (12) como respuesta a una señal de control, y un medio de control (90) conectado operativamente al medio de filtro de mezclado para proporcionar dicha señal de control al medio de dirección asistida (28) como respuesta a la señal de par motor filtrada y mezclada (Tm), caracterizándose por el hecho de que facilita otra función de transferencia dependiente de la frecuencia (K(s)) en el filtro de mezclado con el que se provoca la variación de la ganancia del sistema de dirección en función del componente filtrado de frecuencia más baja, de tal manera que la ganancia de frecuencia alta de dirección asistida es baja para una operación centrada del volante de mano y relativamente más alta para una operación descentrada, dicha ...

Method and apparatus for laminating sheets of flexible porous material

Method and apparatus for laminating sheets of flexible porous material

Verfahren und vorrichtung zur regelung einer elektrischen servolenkung mit adaptiv mischendem drehmomentfilter

Tandem isotachophoresis/zone electrophoresis method and system

A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing- edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected, in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charged sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separate by zone electrophoresis.

Tandem isotachophoresis/zone electrophoresis method and system

A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing- edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected, in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charged sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separate by zone electrophoresis.

Puppe mit einstellbarer Haarlänge

Methods of determining patient response by measurement of HER-3 and P95

The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex and the presence and/or amount of p95 in a sample. The invention also provides antibodies specific for Her-3.

Methods and apparatus for adjusting blood circulation

Embodiments of the invention include methods and devices for increasing blood flow and controlling the temperature of a mammal. The device generally includes collapsible and pliant body elements, capable of expanding from a first volume into an expanded second volume which can then be reduced from the expanded second volume into a pressurized third volume. One or more thermal exchange units can be positioned in the one or more collapsible and pliant body elements. Accordingly, the temperature of the extremity of a mammal can be regulated by providing heating or cooling to the one or more thermal exchange units.