Prokineticin 1 receptor

The present invention relates to methods of monitoring the biological activity of the PK1 receptor.

STIMULATION OF SATIETY HORMONE RELEASE

The present invention provides a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. The present invention also provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery. 1. A method of stimulating the release of satiety hormone in a subject comprising: applying a first electrical stimulus to a tissue of the gastrointestinal system of said subject contemporaneously with a contacting of L-cells of the tissue with a nutrient stimulus.2. The method according to wherein the first electrical stimulus is applied to a mucosal tissue of the gastrointestinal system of the subject.3. The method according to wherein said first electrical stimulus is applied to a mucosal tissue of the ileum.4. The method according to wherein said first electrical stimulus is applied to a mucosal tissue of the distal ileum.5. The method according to wherein the first electrical stimulus is applied at a frequency of about 0.1 Hz to about 90 Hz.6. The method according to wherein the first electrical stimulus is applied at a voltage of about 0.5 V to about 25 V.7. The method according to wherein the first electrical stimulus has a pulse duration of about 3 ms to about 500 ms.8. The method ...

MULTI-BURNER HIGH-PRESSURE PORTABLE STOVE HAVING INDEPENDENTLY CONTROLLED REGULATORS

A multi-burner high-pressure portable stove having independently regulated burners is provided. The stove is especially suitable for camping. The stove provides similar functionality as a typical kitchen range by allowing a user to efficiently control the amount of fuel utilized by each individual burner of the stove. The stove further allows the user to independently control varying flame amounts of each burner so as a user may select between, simmer, medium, high or anything in-between for each burner. The regulators have a dual-lead stem thread knob which allows for quick and easy adjustments. The regulators are safely secured within a housing of the stove. In an embodiment, the regulators may be located outside the housing of the stove. 1) A portable stove comprising:a housing have an open top, a bottom, a front, a back, a first side and a second side;a pressurized gas regulator having a housing having an interior channel wherein the pressurized gas regulator is located completely within the housing of the portable stove;a burner secured to the bottom of the housing; anda pressurized gas containment located outside of the housing of the portable stove wherein the pressurized gas containment holds a flammable pressurized gas; anda tube connecting the pressurized gas regulator to the burner wherein the flammable pressurized gas passes through the pressurized gas regulator, through the tube and through the burner prior to the flammable pressurized gas being ignited.2) The portable stove of further comprising:a dual lead stem having a first end, a second end and a generally cylindrical exterior surface wherein the dual lead stem is partially secured within the interior channel of the pressurized gas regulator wherein the dual lead stem has a plurality of independent threads which wrap around exterior surface and wherein the dual lead stem is rotated within the interior channel of the pressurized gas regulator.3) The portable stove of further comprising:a control ...

Adjustable Warming Blanket

An adjustable warming blanket with a smooth, glossy fabric layer and a fabric layer made of a soft napped material, particularly useful for warming the extremities of an individual, the fabric layers forming a two-layer rectangular fabric structure utilizing a zipper arrangement to adjust the configuration and size of the blanket. 1. An adjustable warming blanket comprisinga rectangular fabric outer layer having a width, a length larger than said width, first and second, parallel, opposed longitudinal edges extending along said length of said outer fabric layer, first and second parallel, opposed widthwise edges extending along said width of said outer fabric layer, and a central section extending widthwise between said opposed longitudinal edges;a rectangular fabric inner layer stitched to said outer fabric layer by a series of angled rows of stitches defining triangular sections therebetween, said inner fabric layer being coextensive with said outer fabric layer and having first and second longitudinal edges juxtaposed, respectively, with said first and second longitudinal edges of said outer fabric layer and having first and second widthwise edges juxtaposed, respectively, with said first and second widthwise edges of said outer fabric layer;said outer and inner fabric layers forming a two-layer rectangular fabric structure having opposing first and second longitudinal ends and having widthwise edges joined together by stitching at said first longitudinal end of said fabric structure;a fiber filling disposed between said outer and inner fabric layers to be confined in said triangular sections; anda zipper arrangement extending along said first longitudinal edges of said outer and inner fabric layers and along said widthwise edges at said second end of said fabric structure whereby said first longitudinal edges can be selectively joined and said second widthwise edges can be selectively joined.2. The adjustable warming blanket recited in wherein said outer fabric ...

Stimulation of satiety hormone release

Prokineticin 1 receptor antagonists for the treatment of pain

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A 1 , L 1 , D, and Q are defined herein.

Prokineticin 1 receptor

The present invention relates to methods of monitoring the biological activity of the PK1 receptor.

Methods of treating inflammation using prokineticin 1 receptor antagonists

The present invention relates to prokineticin 1 receptor antagonists and methods of using the same to modulate intestine epithelial functions and to treat inflammation in the intestine in a mammal.

満腹ホルモン放出の刺激

【課題】胃内容物排出後に小腸に入る栄養素に対する自然のホルモン反応を強化し、これにより肥満又は糖尿病患者に治療的価値をもたらす、部位特異的な方法の提供。 【解決手段】被験者において満腹ホルモンの放出を刺激する方法。栄養素刺激で組織のＬ細胞を収縮させるのと同時に、被験者の胃腸系の管腔組織に第一電気刺激を印加することが含まれる。更に、体重減少手術に対する患者反応を予測するための方法。これには、栄養素刺激で組織のＬ細胞を収縮させるのと同時に、該患者の胃腸系の組織に第一電気刺激を印加することと、該患者における電気刺激の影響を評価することと、該影響を、体重減少手術に対する該患者の反応と相互に関連づけることと、が含まれる治療方法。 【選択図】図１

Stimulation of satiety hormone release

The present invention provides, among other things, a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. In another aspect, the present invention provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.