MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. 150-. (canceled)51. An isolated antibody , or antigen binding fragment thereof , that specifically binds to a complex of an IL-12 p40 polypeptide and an IL-B30 polypeptide , wherein:a) the IL-12 p40 polypeptide comprises the mature sequence of SEQ ID NO:20; andb) the IL-B30 polypeptide comprises the mature sequence of SEQ ID NO:2;wherein the antibody, or antigen binding fragment thereof, binds to sequences within the mature sequence of SEQ ID NO:20 and the mature sequence of SEQ ID NO:2; andfurther wherein the antibody, or antigen binding fragment thereof does not bind to either the mature human IL-12p40 polypeptide alone or the mature human IL-B30 polypeptide alone, andyet further wherein the complex of IL-12p40 and IL-B30 is generated by co-expressing nucleic acids encoding the respective polypeptide chains in a mammalian cell and collecting the IL-12p40/IL-B30 complex secreted from the cell.52. The antibody or antigen binding fragment of comprising a monoclonal antibody or antigen binding fragment thereof.53. The antibody or antigen binding fragment of comprising a humanized antibody or antigen binding fragment thereof.54. The antigen binding fragment of comprising an Fv fragment claim 51 , an Fab fragment claim 51 , or an F(ab′)2 fragment.55. A pharmaceutical formulation comprising:{'claim-ref': {'@idref': 'CLM-00051', 'claim 51'}, 'a) the antibody or antigen binding fragment of ; and'}b) a pharmaceutically acceptable carrier.56. An isolated antibody claim 51 , or antigen binding fragment thereof claim 51 , that specifically binds to a complex of an IL-12 p40 polypeptide and an IL-B30 polypeptide claim 51 , wherein:a) the IL-12 p40 polypeptide consists of the mature sequence of SEQ ID NO:20; andb) the IL-B30 ...

Mammalian interleukin-12 P40 and interleukin B30, combinations thereof, antibodies, uses in pharmaceutical compositions

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian interleukin-12 p40 and interleukin b30. combinations thereof. antibodies. uses in pharmaceutical compositions

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian genes; related reagents and methods

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian Cytokines; Related Reagents and Methods

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian cytokines; related reagents and methods

IL-12P40 and IL-B30 polypeptide complex

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.