Suture securement devices

Disclosed herein are exemplary embodiments of suture securement devices that replace the need to tie knots in sutures. Some embodiments comprise an annular outer body and one or more suture engagement tabs extending inwardly from the outer body. The devices can comprise a superelastic and/or shape-memory material and have a generally in-plane initial configuration. The suture engagement portions are deformable out-of-plane to an active configuration with the outer body compressed and the tabs interlocked with each other. The device can be heat-set in the deformed configuration. The interlocked tabs exert a pinching force on sutures passing between them that restricts the sutures from sliding through the opening in one longitudinal direction.

TRANS-SEPTAL CLOSURE AND PORT DEVICE

A septal closure and port device for implantation in the atrial septum of a patient's heart includes an expandable frame having a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further include a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument to be inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart. 1. A septal closure and port device for implantation in an atrial septum of a patient's heart , comprising:an expandable frame comprising a central portion defining a lumen, and first and second opposing end portions extending from opposite ends of the central portion, the frame configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion and can compress the atrial septum therebetween; anda valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame, the valve member configured to permit a medical instrument inserted in the right atrium to pass through the lumen and the valve member and into the left atrium.2. The device of claim 1 , wherein the frame comprises a plurality of metal frame members.3. The device of claim 2 , wherein each of the first and second end portions of the frame ...

Sealing devices and related delivery apparatuses

Embodiments of the present disclosure are directed to implantable sealing devices, delivery apparatuses, and methods of their use, for closing surgical openings or defects in a sidewall of a vessel in a subject. In several embodiments, the disclosed implantable sealing devices, delivery apparatuses, and methods can be used to close a surgical opening in a sidewall of the heart.

SUTURE SECUREMENT DEVICES

Disclosed herein are exemplary embodiments of suture securement devices that replace the need to tie knots in sutures. Some embodiments comprise an annular outer body and one or more suture engagement tabs extending inwardly from the outer body. The devices can comprise a superelastic and/or shape-memory material and have a generally in-plane initial configuration. The suture engagement portions are deformable out-of-plane to an active configuration with the outer body compressed and the tabs interlocked with each other. The device can be heat-set in the deformed configuration. The interlocked tabs exert a pinching force on sutures passing between them that restricts the sutures from sliding through the opening in one longitudinal direction. 1. A device for securing one or more sutures , comprising:a generally disk-shaped body having an annular outer edge;a first tab extending from a first side of the annular outer body and a second tab extending from a second side of the annular outer body;a pair of curved slots passing through the body inward from the outer edge that define sides of the two tabs;a middle slit connecting the curved slots and separating the tabs, the slit and curved slots generally forming a closed H-shaped opening through the body, the slit being sized to receive and hold one or more sutures and opposed edges of the tabs across the slit form suture engagement portions; andwherein the device comprises an elastically resilient material and has a natural configuration when no sutures are positioned in the slit;wherein the suture engagement portions are elastically deformed to an active configuration when one or more sutures are positioned through the opening; andwherein, in the active configuration, the suture engagement portions exert a pinching force on the one or more sutures that restricts the sutures from sliding through the slit in at least one longitudinal direction of the sutures.2. The device of claim 1 , wherein the device has a ...

BICUSPID VALVE DISSECTION DEVICE

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection. 1. A device for bisecting heart valve leaflets , comprising:a steerable catheter shaft;a foot sheath slidingly disposed within the steerable catheter shaft;a foot element at a distal end of the foot sheath, the foot element configured to engage a valve leaflet, the foot element comprising a foot opening;a foot alignment magnet disposed at the foot element;a cutting element sheath slidingly disposed within the steerable catheter, the cutting element sheath comprising a cutting element sheath distal end;a cutting element alignment magnet at the cutting element sheath distal end;a cutting element selectively extendable from the cutting element sheath distal end and into the foot opening.2. The device of claim 1 , wherein the foot element is configured when extended distally from the catheter shaft to extend sideways from the foot sheath.3. The device of claim 1 , wherein the foot element when extended distally from the steerable catheter shaft comprises an overall length of 0.5 to 2 centimeters.4. The device of claim 2 , wherein the foot element comprises nitinol.5. The device of claim 1 , wherein the cutting element comprises a motor-driven rotating rod having an abrasive surface.6. The device of claim 1 , wherein the cutting element comprises an ...

Trans-septal closure and port device

A septal closure and port device for implantation in the atrial septum of a patient's heart comprises an expandable frame can comprise a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further comprise a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart.

SEALING DEVICES, RELATED DELIVERY APPARATUSES, AND USES THEREOF

Embodiments of the present disclosure are directed to implantable sealing devices, delivery apparatuses, and methods of their use, for closing surgical openings or defects in a sidewall of a vessel in a subject. In several embodiments, the disclosed implantable sealing devices, delivery apparatuses, and methods can be used to close a surgical opening in a sidewall of the heart. 1. An implantable sealing device for closing an aperture in a vessel sidewall in a subject , comprising: the proximal and distal fingers extend radially outward from the longitudinal axis when the annular frame is in a non-constrained state; and', 'the distal fingers can be moved to a constrained state pointing in a substantially axial direction for insertion through the aperture in the vessel sidewall and can self-extend to the non-constrained state, thereby pinching the vessel sidewall between the proximal and distal fingers; and, 'an annular puncture frame comprising a longitudinal axis, a plurality of proximal fingers coupled to a proximal end of the frame, and a plurality of distal fingers coupled to a distal end of the frame; wherein'}a tubular sealing member comprising a distal end coupled to the puncture frame, the tubular sealing member comprising an open state that allows access to a lumen of the vessel via the aperture; andwherein the tubular sealing member can be moved to a sealed state to close the aperture in the vessel sidewall.2. The sealing device of claim 1 , further comprising a sealing skirt coupled to the puncture frame.3. The sealing device of claim 1 , wherein the tubular sealing member can be angularly rotated to twist the tubular sealing member to the sealed state to close the aperture in the vessel sidewall.4. The sealing device of claim 3 , wherein a proximal end of the tubular sealing member is coupled to a twisting frame claim 3 , and wherein the twisting frame can be angularly rotated to twist the tubular sealing member to the sealed state to close the aperture ...

MULTIPLE-FIRING SECURING DEVICE AND METHODS FOR USING AND MANUFACTURING SAME

A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location. 1. A multiple-fire securing device , comprising:a plurality of securing structures each defining an inner securing orifice;a hollow outer shaft; longitudinally movable within the outer shaft; and', 'having a distal end shaped to temporarily contact one of the securing structures;, 'a reloadera rail disposed within the reloader and on which the plurality of securing structures are disposed, the rail having an installing location; and moving the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position; and', 'moving the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures., 'a reloader movement assembly2. The device according to claim 1 , wherein the inner clipping orifice is an H-shaped orifice.3. The device according to claim 1 , wherein the rail has an H-shape cross-section.4. The device according to claim ...

Trans-septal closure and port device

A septal closure and port device for implantation in the atrial septum of a patient's heart comprises an expandable frame can comprise a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further comprise a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart.

APICAL PUNCTURE ACCESS AND CLOSURE SYSTEM

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration. 1. A device for providing access through and sealing of a puncture in tissue , comprising:a generally elongated and radially-expandable main body, the main body comprising a distal portion having a distal end and a distal lumen and a proximal portion having a proximal end and a proximal lumen, the distal lumen being sized to receive the proximal lumen, thereby creating a continuous internal lumen through the main body, the main body having an unexpanded configuration having an unexpanded outer diameter, the main body further having an expanded configuration having an expanded outer diameter;a plurality of prongs extending from the distal end of the distal portion of the main body, each of the prongs comprising a proximal end secured to the distal end of the distal portion of the main body, each of the prongs further comprising a distal end, wherein each of the prongs comprises a straight configuration wherein the prong is generally straight and extends generally distally from the main body distal portion such that the distal end of the prong is positioned distally of the main body, each of ...

BICUSPID VALVE DISSECTION DEVICE

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection. 1. A device for bisecting heart valve leaflets , comprising:a steerable catheter shaft;a foot sheath slidingly disposed within the steerable catheter shaft;a foot element at a distal end of the foot sheath, the foot element configured to engage a valve leaflet, the foot element comprising a foot opening;a foot alignment magnet disposed at the foot element;a cutting element sheath slidingly disposed within the steerable catheter, the cutting element sheath comprising a cutting element sheath distal end;a cutting element alignment magnet at the cutting element sheath distal end; anda cutting element selectively extendable from the cutting element sheath distal end and into the foot opening.2. The device of claim 1 , wherein the foot element is configured when extended distally from the catheter shaft to extend sideways from the foot sheath.3. The device of claim 1 , wherein the foot element when extended distally from the steerable catheter shaft comprises an overall length of 0.5 to 2 centimeters.4. The device of claim 2 , wherein the foot element comprises nitinol.5. The device of claim 1 , wherein the cutting element comprises a motor-driven rotating rod having an abrasive surface.6. The device of claim 1 , wherein the cutting element comprises an ...

B titanium compositions and methods of manufacture thereof

A composition comprises about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition. A method for making an article comprises cold-working a shape from a composition comprising about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition; solution heat treating the shape; and cooling the shape.

Method for manufacturing superelastic .beta. titanium articles and the articles derived therefrom

An article is manufactured from a composition comprising about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% chromiu m, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance bein g titanium, wherein the weight percents are based on the total weight of the alloy composition. An article is manufactured by a method comprising forming a shape from a composition comprising about 8 to about 10 wt% molybdenum, abou t 2.8 to about 6 wt% aluminum, up to about 2 wt% chromium, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherei n the weight percents are based on the total weight of the alloy composition; cold working the shape; and heat treating the shape.

Manufacture of metal tubes

The manufacture of seamless tubes in which the process includes providing an assembly having a metal tube blank (1), and an elongate metal core (2) of shape memory effect material which is surrounded and contacted by the tube blank (1) with a minimal gap. The assembly is elongated by mechanical working thereof at an elevated temperature until the tube blank (1) has been converted into a tube of desired dimensions. After the elongation step, the core (12) is subjected to a treatment which results in the core being in a stretched condition throughout its length, and does not substantially stretch the tube (11). The core is removed from the tube, and subsequently subjected to drawing passes over a nondeformable mandrel thereby refining the precision of diametric and wall dimensions with improved ID and OD surface quality. There is also decoring and reinserting to improve final dimensions which results in the ability to fabricate smaller, longer tubes (111).

Titanium compositions and methods of manufacture thereof

A composition comprises about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition. A method for making an article comprises cold working a shape from a composition comprising about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition; solution heat treating the shape; and cooling the shape.

Medical devices having drug eluting properties and methods of manufacture thereof

A medical device comprises a shape memory alloy having a reverse martensitic transformation start temperature of greater than or equal to about 0°C; and a drug coating comprising a polymeric resin and a biologically active agent. A method of manufacturing a stent comprises cold forming a shape memory alloy from a wire; heat treating the cold formed shape memory alloy at a temperatures greater than that at which a martensitic transformation can occur; and coating the stent with a drug coating comprising a biologically active agent.

Apical puncture access and closure system

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration.

Heart valve implantation methods

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

Optical heterodyne scanning type holography device

There is disclosed an optical heterodyne scanning holography device capable of recording and reconstructing a holographic image of an object in real time by optical heterodyne-scanning the object, capturing a scattered wave from the object by a photodetector, and converting a heterodyne output current from the photodetector to a spatial light modulator for coherent processing optically.

Pseudoelastic β titanium eyeglass components

A new eyeglass frame, eyeglass frame component and method for making eyeglass frames or parts thereof of a nickel-free titanium based SMA. A pseudoelastic β titanium alloy is used which has superior fabricating characteristics combined with weldability with pseudoelastic properties over the temperature range of −25° C. to 50° C. making this alloy ideally suited for the manufacture of various eyeglass components. The disclosed eyeglass component alloy is a β titanium alloy contains alloying elements of molybdenum between 10.0 and 12.0 weight percent, aluminum between 2.8 and 4.0 weight percent, chromium and vanadium between 0.0 and 2.0 weight percent, and niobium between 0.0 and 4.0 weight percent. The eyeglass components fabricated from this alloy exhibit a strain recovery of up to 3.5% deformation, a lower stiffness than conventional binary nickel titanium alloys yielding superior wearer comfort.

Suture securement devices

Disclosed herein are exemplary embodiments of suture securement devices that replace the need to tie knots in sutures. Some embodiments comprise an annular outer body and one or more suture engagement tabs extending inwardly from the outer body. The devices can comprise a superelastic and/or shape-memory material and have a generally in-plane initial configuration. The suture engagement portions are deformable out-of-plane to an active configuration with the outer body compressed and the tabs interlocked with each other. The device can be heat-set in the deformed configuration. The interlocked tabs exert a pinching force on sutures passing between them that restricts the sutures from sliding through the opening in one longitudinal direction.

Implantable pressure sensor packaging

An implantable sensor device includes a sensor- support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor- support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Improved radiopacity in implantable medical devices

A method of manufacturing an implantable medical device with radiopaque properties, the method includes converting an ingot of a metal alloy with radiopaque and super elastic properties into a rod. The method also includes drilling the rod to create a hollow tube. The method also includes drawing the tube. The method also includes manufacturing an implantable medical device form from the tube. The method also includes finishing the implantable medical device form to create an implantable medical device.

Bicuspid valve dissection device

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

Biscuspid valve dissection device

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

Dispositivo de disección de válvula bicúspide

La invención es un dispositivo, sistema y método para reparar la función de la válvula cardíaca, que puede incluir dividir las valvas de la válvula nativa para mejorar el despliegue de una válvula cardíaca protésica en el anillo de la válvula nativa. La invención puede incluir un catéter que tiene un eje de elemento de corte con un elemento de corte configurado para perforar una valva de válvula y/o realizar un corte controlado a través de la valva. El dispositivo puede tener un pie extensible configurado para colocarse en un lado opuesto de la valva de la válvula desde el eje del elemento de corte. El dispositivo puede incluir imanes para guiar el elemento de corte y/o el eje del elemento de corte en alineación adecuada con el pie extensible y para mantener los elementos en su lugar durante la bisección de la valva. (Traducción automática con Google Translate, sin valor legal)

Bicuspid valve dissection device

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

METHOD FOR MANUFACTURING SUPERELASTIC β TITANIUM ARTICLES AND THE ARTICLES DERIVED THEREFROM

An article is manufactured from a composition comprising about 8 to about 10 wt% molybedenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% chromium, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition. An article is manufactured by a method comprising forming a shape form a composition comprising about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% chromium, up to about 2 wt% vanadium up to about 4 wt% nobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition; cold working the shape; and heat treating the shape.

二尖弁切離デバイス

【課題】切断要素を有するカテーテルを使用して心臓弁尖を二分するための方法および装置を提供する。【解決手段】本発明は、天然弁輪内における人工心臓弁の展開を改善するために天然弁尖を二分することを含み得る、心臓弁機能を修復するためのデバイス、システム、および方法である。本発明は、弁尖を穿孔するおよび／または弁尖に制御的な切断を行うように構成された切断要素を有する切断要素シャフトを有するカテーテルを含み得る。このデバイスは、切断要素シャフトから弁尖の対向側部上に位置決めされるように構成された延在可能フットを有し得る。デバイスは、延在可能フットとの適切な整列状態に切断要素および／または切断要素シャフトを案内するために、ならびに弁尖の二分中にこれらの要素を定位置に保持するために、磁石を備え得る。【選択図】図７

Empaque de sensor de presión implantable

Un dispositivo sensor implantable que incluye un sustrato de soporte del sensor, un dispositivo sensor de presión de sistemas microelectromecánicos (MEMS) que se monta en el sustrato de soporte del sensor, un medio de transducción que se aplica sobre el dispositivo sensor de presión y una capa de biocompatibilidad que se aplica sobre el medio de transducción.

Implantable pressure sensor packaging

An implantable sensor device includes a sensor-support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor-support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Implantable pressure sensor packaging

An implantable sensor device includes a sensor- support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor- support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Implantable pressure sensor packaging

An implantable sensor device includes a sensor- support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor- support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Implantable pressure sensor packaging

An implantable sensor device includes a sensor- support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor- support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Suture securement devices

Disclosed herein are exemplary embodiments of suture securement devices that replace the need to tie knots in sutures. Some embodiments comprise an annular outer body and one or more suture engagement tabs extending inwardly from the outer body. The devices can comprise a superelastic and/or shape-memory material and have a generally in-plane initial configuration. The suture engagement portions are deformable out-of-plane to an active configuration with the outer body compressed and the tabs interlocked with each other. The device can be heat-set in the deformed configuration. The interlocked tabs exert a pinching force on sutures passing between them that restricts the sutures from sliding through the opening in one longitudinal direction.

Suture securement devices

Empaque de sensor de presion implantable.

Un dispositivo sensor implantable que incluye un sustrato de soporte del sensor, un dispositivo sensor de presión de sistemas microelectromecánicos (MEMS) que se monta en el sustrato de soporte del sensor, un medio de transducción que se aplica sobre el dispositivo sensor de presión y una capa de biocompatibilidad que se aplica sobre el medio de transducción.

Method for manufacturing superelastic beta-titanium articles and the articles derived therefrom

An article is manufactured from a composition comprising about 8 to about 10 wt% molybedenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% chromium, up to about 2 wt% vanadium, up to about 4 wt% niobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition. An article is manufactured by a method comprising forming a shape form a composition comprising about 8 to about 10 wt% molybdenum, about 2.8 to about 6 wt% aluminum, up to about 2 wt% chromium, up to about 2 wt% vanadium up to about 4 wt% nobium, with the balance being titanium, wherein the weight percents are based on the total weight of the alloy composition; cold working the shape; and heat treating the shape.

Manufacture of metal tubes

Bicuspid valve dissection device

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

Heart valve implantation methods

The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.

Trans-septal closure and port device

A septal closure and port device for implantation in the atrial septum of a patient's heart includes an expandable frame with a central portion defining a lumen, and first and second opposing end portions. The frame can expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can also have a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member permits a medical instrument to be inserted through the lumen and into the left atrium, for performing a subsequent medical procedure in the left side of the heart.