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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 4. Отображено 4.
04-07-2023 дата публикации

Noraconitine derivative as well as preparation method and application thereof

Номер: CN116375643A
Автор: WU SHANCHAO, SHENG CHUNQUAN, SU SIJIA, BAI XUEXIN, HUANG YAHUI, DONG GUOQIANG, PAN ZHIZHI, CHEN SHUQIANG, XIA ZHEWEI
Принадлежит:

The invention discloses a noraconitine derivative or a pharmaceutical salt thereof. The structure of the noraconitine derivative is one of the following structures. An in-vitro antibacterial activity test of the noraconitine derivative shows the characteristics of good anti-Fn activity and specificity; the noraconitine derivative has no inhibition effect on common intestinal bacteria such as escherichia coli, salmonella paratyphi B, staphylococcus aureus, faecalis coccus and shigella flexneri, has a specific Fn inhibition effect, and can be used for treating diseases caused by fusobacterium nucleatum.

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Номер записи: 1
23-06-2023 дата публикации

Evodiamine fluorescent probe and application thereof

Номер: CN116283983A
Автор: WU SHANCHAO, SHENG CHUNQUAN, LI KELIANG, DONG GUOQIANG, LI XINGLIN, MA ZONGLIN, SUN YUHANG, CHEN SHUQIANG, XIA ZHEWEI, BAI XUEXIN, CHEN YUPING
Принадлежит:

The invention discloses an evodiamine fluorescent probe or a pharmaceutical salt thereof, the structural general formula of the evodiamine fluorescent probe is shown in the specification, the compound shows good tumor cell inhibition activity, Probe-1, Probe-2 and Probe-4 break under the activation of nitroreductase and generate fluorescence, namely, the evodiamine fluorescent probe has nitroreductase targeting property, and the evodiamine fluorescent probe or the pharmaceutical salt thereof has good tumor cell inhibition activity. According to the present invention, the 3-fluoro-10-hydroxyevodiamine is used as the probe, the probe breaks under the action of nitroreductase to release fluorophores and pharmacophores, the fluorescence property of the probe is optimal, tumor treatment and hypoxia level monitoring are expected to be simultaneously achieved, and in addition, the toxicity of the probe to normal cells is significantly lower than that of the 3-fluoro-10-hydroxyevodiamine.

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Номер записи: 2
04-07-2023 дата публикации

DCLK1 protein degradation targeting chimera and application thereof

Номер: CN116375713A
Автор: SHENG CHUNQUAN, WU SHANCHAO, LI KELIANG, LIU YANG, DONG GUOQIANG, CHEN YUPING, SUN YUHANG, WANG LEI, BAI XUEXIN, XIA ZHEWEI
Принадлежит:

The invention discloses a compound or a pharmaceutical salt thereof, the structural general formula of the compound is shown in the specification, the compound shows good DCLK1 protein degradation activity, and a DCLK1 protein degradation activity test result shows that compounds P-11, P-12 and P-14 taking pomalidomide as an E3 ligase ligand have good degradation activity and are superior to compounds taking VHL as the E3 ligase ligand.

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Номер записи: 3
15-08-2023 дата публикации

Battery repairing device and system of new energy vehicle

Номер: CN116598609A
Автор: XIA ZHEWEI, FENG XINWANG, ZHANG HAISHENG, XIA GUOZHU, XIA GUOHUA
Принадлежит:

The invention relates to the field of new energy vehicle maintenance, and discloses a battery repair device and system for a new energy vehicle, and the device and system have the following beneficial effects: 1, contact probes are arranged at the two sides of a battery, and the contact probes are connected with each battery monomer in sequence in the moving process, so that in-situ detection and repair operation can be conveniently realized, and the repair efficiency is improved; the device is more convenient, manual processing is not needed, meanwhile, the possibility of electric shock caused by manual operation is avoided, connection between the battery and the vehicle and connection between the power supply device and the battery repairing device cannot be conducted synchronously, and mutual interference between the battery and the vehicle and between the power supply device and the battery repairing device is avoided; 2, the whole battery repairing device controls the sliding, overturning ...

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Номер записи: 4