22-02-2018 дата публикации
Номер: US20180051006A1
Принадлежит:
Disclosed are benzimidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure 2. The compound of or a pharmaceutically acceptable salt claim 1 , prodrug or N-oxide thereof claim 1 , or solvate or hydrate thereof claim 1 , wherein{'sup': 1', '2', 'A', 'Ax, 'sub': 3-8', '0-6', '0-6', '0-6', '0-6', '0-6', '3-8', '0-6', '0-6', '0-6', '1-6', '1-6', '1', '6', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'claim-text': {'sup': 'Ax', 'sub': 1-6', '1-6', '1', '6', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'wherein each —Ris independently halogen, cyano, Calkyl, Chaloalkyl, —C-Calkoxy, —OR, —SR, —NR, —C(O)R, —C(O)OR, —C(O)NR, —S(O)NR, —S(O)R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR, —N(R)C(O)OR, —N(R)C(O)NR, —N(R)S(O)R, —OP(O)(OR)or —CH—OP(O)(OR);'}, 'Rand Rtogether with the atoms to which they are attached form ring A, wherein ring A is 5- or 6-membered Het optionally substituted with one or more Rgroups that are each independently CCak(Calkyl), Hca(Calkyl), Ar(Calkyl), Het(Calkyl), —O—Calkyl-CCak, —O—Calkyl-Hca, —O—Calkyl-Ar, —O—Calkyl-Het, halogen, cyano, Calkyl, Chaloalkyl, —C-Calkoxy, —OR, —SR, —NR, —C(O)R, —C(O)OR, —C(O)NR, —S(O)NR, —S(O)R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR, —N(R)C(O)OR, —N(R)C(O)NR, —N(R)S(O)R, —OP(O)(OR)or —CH—OP(O)(OR), wherein each Ar, Het, Cak, Hca, alkyl, alkoxy and haloalkyl group is optionally substituted by one or two —Rgroups,'}{'sup': 1', '2', 'A, 'sub': 1-6', '1-6', '1', '6', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'or one of Rand Ris Ar or Het, wherein Ar and Het are substituted with one or more Rgroups, and the other is hydrogen, halogen, cyano, Calkyl, Chaloalkyl, —C-Calkoxy, —OR, —SR, —NR, —C(O)R, —C(O)OR, —C(O)NR, —S(O)NR, —S(O)R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR, —N(R)C(O)OR, —N(R)C(O)NR, —N(R)S(O)R, —OP(O)(OR)or —CH—OP(O)(OR).'}3. The compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , prodrug or N-oxide ...
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