10-04-2014 дата публикации
Номер: US20140099311A1
Автор:
Chen Yan,
Gardner Debra,
Knight David M.,
Lark Michael W.,
Liang Bailin,
Marquis David M.,
Shealy David J.,
Smith Eric Michael,
Song Xiao-Yu R.,
Stojanovic-Susulic Vedrana,
Sweet Raymond W.,
TAM Susan H.,
Vasserot Alain P.,
Wu Sheng-Jiun,
Yang Jing
Принадлежит:
An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. 1. A lyophilized pharmaceutical formulation of an isolated IL-6 antibody , comprising at least one light chain variable region and one heavy chain variable region , said light chain variable region comprising:{'sub': 1', '2', '3', '4', '5', '1', '2', '3', '4', '5, 'a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:132 comprising the sequence S-X-X-X-X-V-X-Y-M-Y, wherein Xis A or G, Xis S or R, Xis H, I, S, or Y, Xis S or Y, and Xis S or F;'}{'sub': 6', '7', '8', '6', '7', '8, 'a CDRL2 amino acid sequence of SEQ ID NO:133 comprising the sequence D-X-S-X-L-X-S, wherein Xis F, L, M, or T, Xis N or E, and Xis A or T; and'}{'sub': 9', '10', '9', '10, 'a CDRL3 amino acid sequence of SEQ ID NO:134 comprising the sequence X-X-W-S-G-Y-P-Y-T, wherein Xis M, C, or S, and Xis Q or C; said heavy chain variable region comprising{'sub': 11', '12', '13', '14', '11', '12', '13', '14, 'a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:135 comprising the sequence G-F-X-X-S-X-F-A-X-S, wherein Xis T or Q, Xis F, S, or T, Xis S or P, and Xis L or M;'}{'sub': 15', '16', '17', '18', '19', '20', '21', '22', '23', '15', '16', '17', '18', '19', '20', '21', '22', '23, 'a CDRH2 amino acid sequence of SEQ ID NO:136 comprising the sequence K-X-S-X-G-G-S-X-X-Y-X-X-D-T-X-X-X, wherein Xis A or I, Xis S or P, Xis Y or W, Xis T, E, or Y, Xis Y or F, Xis P, S, D, or F, Xis V or D, Xis T or A, and Xis G or P; and'}{'sub': 24', '25', '24', '25, 'a CDRH3 amino acid sequence of SEQ ID NO:137 comprising the sequence Q-L-W-G-X-Y-A-L-D-X, wherein Xis S, Y, T, or N, and Xis Y, T, F, or I.'}2. The lyophilized pharmaceutical formulation of claim 1 , ...
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