01-09-2022 дата публикации
Номер: US20220273642A1
The present disclosure relates to an effect of inhibiting cancer metastasis by treatment of chlorphenesin and hydroxychloroquine alone or in combination. Chlorphenesin or hydroxychloroquine has the effect of inhibiting the metastasis and invasion of cancer cells. In particular, since it was identified that a combination thereof has a synergistic action, it is possible to effectively prevent or treat cancer metastasis by administering chlorphenesin and hydroxychloroquine respectively or in combination thereof. 1. A method for inhibiting metastasis or invasion of cancer , or treating cancer , comprising administering a composition comprising at least one selected from the group consisting of chlorphenesin , chlorphenesin carbamate and hydroxychloroquine , or a pharmaceutically acceptable salt thereof as an active ingredient to a subject in need thereof.2. The method of claim 1 , wherein the composition comprises (i) hydroxychloroquine claim 1 , (ii) chlorphenesin and hydroxychloroquine claim 1 , or (iii) chlorphenesin carbamate and hydroxychloroquine as an active ingredient.3. The method of claim 1 , wherein the cancer is colorectal cancer claim 1 , pancreatic cancer or biliary tract cancer.4. The method of claim 1 , wherein the hydroxychloroquine is included in the form of hydroxychloroquine sulfate. The present application is a continuation-in-part of U.S. patent application Ser. No. 16/484,305, filed Aug. 7, 2019, which is a National Stage of International Application No. PCT/KR2018/001549, filed Feb. 6, 2018, which claims priority to Korean Patent Application No. 10-2017-0016587, filed Feb. 7, 2017 and Korean Patent Application No. 10-2018-0014306, filed Feb. 6, 2018, the above-noted applications incorporated herein by reference in their respective entireties.The present disclosure relates to a composition for inhibiting cancer metastasis, and to an effect of inhibiting cancer metastasis and invasion by treatment of chlorphenesin and hydroxychloroquine alone or in ...
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