Preparation and application of 3,7,10-trimethyl-silatrane Schiff base derivatives

Negative pressure closed drainage device and drainage method

The invention relates to a negative pressure closed drainage device and a drainage method using the same. The device is optimized on the respect of negative pressure, the negative pressure is minus 40mmHg to minus 200mmHg, thereby being especially suitable to treat skin empyrosis and the like. In addition, the invention also relates to an application of the negative pressure in the device for treating the skin empyrosis, a skin grafting method and the like.

Method for preparing the total sennoside in senna

A medical application of the general sennoside extracted from senna leaf in preparing the medicines for treating osteoporosis is disclosed. Its preparing process includes such steps as immersing, seeping, alkaline macroreticular resin adsorption, acidic macroreticular resin adsorption, recovering and drying.

4,6-dimethyl-oxazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione derivative acting on FGF receptor

The invention discloses a 4,6-dimethyl-oxazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione derivative acting on a fibroblast growth factor (FGF) receptor. A target compound is prepared by implementing nitrosation on 1,3-dimethyl pyrimidine-2,4,6(1H,3H,5H)-trione which serves as a starting material through NaNO2, reducing the material through Na2S2O4, implementing a Schiff alkali reaction with aromatic aldehyde, and finally cyclizing through SOCl2. The 4,6-dimethyl-oxazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione derivative disclosed by the invention has a certain inhibiting function on experimental cells and shows a certain antitumor activity. For an H460 cell, IC50 values of compounds N5a, N5g and N5k are less than that of a positive control drug; for a B16F10 cell, IC50 values of compounds N5f, N5h and N5i are less than IC50 value of the positive control drug; for an A549 cell, IC50 value of the positive control is relatively high, and IC50 values of compounds N5f, N5g, N5h and N5l are less than IC50 ...

Method for preparing electrochemical sensor of Nano silver particle, and application

A method for preparing electrochemical transducer of nanosilver particle includes preparing nanosilver sol-solution by reacting on NaBH4 solution with AgNO3 solution, drip-coating obtained sol-solution on silver plate electrode and forming electrochemical transducer of nanosilver particle by drying said electrode with air.

Method for synthesizing 3,4-di-oxygen-[3-benzene alkene propionyl]quinic acid compounds

The invention relates a method for synthesizing 3,4-di-o-[3-phenyl propionyl] quinic acid compounds, which comprises allowing substituted beta-phenylacrylic acid compounds (II) and quinic acid lactones (III) to condensate in the presence of dicyclohexylcarbodiimide (DCC) and analog thereof as condensing agent and organic alkali as catalyst to obtain compounds (IV), and hydrolyzing to obtain compounds (I). The condensation reaction is carried out in organic solvent, and hydrolysis is carried out in diluted acid solution or alkali condition such as sodium methoxide and sodium ethoxide. The method has mild reaction condition, simple operation, short step, simple post treatment, and middle to good yield.

Disubstituted benzene alkene propionyl resorcinol compounds and medical use

The invention relates to a bi-substituted phenyl allyl acyl resorcin compound indicated by Formula (I) and the pharmaceutical application, in particular to a compound in Formula (I) and the medicine salt, as well as a preparation method of the compounds and the pharmaceutical application and a drug composition containing the compound. The compound in Formula (I) and the medicine salt thereof, as well as 1, 3-bi-oxygen-[3-(4-metoxybenzene) allyl acyl]-5-methyl resorcin and the medicine salt thereof, have the function of inhibiting HBsAg and display certain cytotoxicity to four-strain human tumor cells. The compound can be used to prepare the medicine for curing hepatitis B infectious diseases and tumor diseases in anticipation.

2-Amino-8-substituted guanine derivative with IKK-beta as target spot, as well as application and preparation method thereof

The invention discloses a 2-amino-8-substituted guanine derivative with IKK-beta as a target spot, as well as an application and a preparation method thereof. The inhibition ratio of the inhibitory activity, to A549 cells, of the compounds is increased along with the increase of concentrations of drugs; however, the compounds basically have no inhibition effect on cell strains b16-f10, H460 and U251, and the selective inhibition effect is specifically significant when the compounds are taken as specific anti-tumor medicines.

Method for preparing o-dihydroxyflavone-selenium complexes and medical use

The present invention relates to synthesis process and medicinal use of o-dihydroxyflavone-selenium complex. The o-dihydroxyflavone-selenium complex in the structure as shown may be applied in preparing health product, pesticide, plant growth regulator, feed additive, immunomodulator, antitumor medicine, antibacterial medicine, etc.

Pharmaceutical use of dandelion xylogen acid for inhibiting acetylcholine esterase

The present invention relates to lignin acid which is obtained by being separated from taraxacum plant and the strong activity of the compound of inhibiting acetylcholinesterase. Mongolian taraxacum acid A is prepared by being separated and purified from the taraxacum, which is 6, 9, 10-trihydroxy- xanthene-1, 2-dicarboxylic acid that has obvious inhibiting effect towards the acetylcholinesterase, therefore the compound, officinal salt thereof and medicine combination which is made from the medicine excipient or the carrier allowed by the preparation can be expected with a purpose of being used as a drug for remedying the senile dementia.

Method for resolving curcumenol epoxy chirality isomer by ionic liquid

The invention relates to a method for resolving curcumenol epoxy chirality isomer by ionic liquid. Quaternary ammonium salt type ionic liquid containing boron tetrafluoride or phosphorus hexafluoride anion is taken as resolving agent, the principle that complexes formed by two optically pure curcumenol epoxidation enantiomers with ionic liquid has obviously different solubility properties in the ionic liquid is utilized, the two complexes are conveniently separated, decomposition and purification are respectively carried out on the complexes, so as to respectively obtain two high quality and high enantiomeric excess (e. e%) optically pure curcumenol epoxidation enantiomers. The invention has simple post treatment, requires no conventional optically pure chirality compound to be taken as resolving agent, has low ionic liquid consumption, can recycle the ionic liquid and is applicable to mass production.

IKK-beta-targeted 2-acetamido-8-substituted guanine derivative, and application and preparation method thereof

The invention discloses an IKK-beta-targeted 2-acetamido-8-substituted guanine derivative, and an application and a preparation method thereof. The A549 cell inhibition activity of the above compound increases if the administration concentration increases, and the compound basically has no inhibition effect on b16-f10, H460 and U251 cell strains, so the selective inhibition effect is of special significance for being used as a specific antitumor medicine.

Technology for separating glutaric acid in mixed dibasic acid through absorption method by macroporous absorbent resin combined with crystallization method

The invention relates to the separation of glutaric acid in mixed dibasic acid through an absorption method by macroporous absorbent resin combined with a crystallization method so as to obtain a glutaric acid with high purity. The technology comprises the following steps: absorbing the mixed dibasic acid to the macroporous absorbent resin according to a certain proportion; eluting the resin by distilled water and a gradient ethanol aqueous solution to obtain four positions of A, B, C, and D; recovering solvents from eluates of the four positions till the eluates are dry; and performing crystallization process by chloroform to obtain glutaric acid.

Method for synthesizing 3,4-di-oxygen-[3-benzene alkene propionyl]quinic acid compounds

The invention relates a method for synthesizing 3,4-di-o-[3-phenyl propionyl] quinic acid compounds, which comprises allowing substituted beta-phenylacrylic acid compounds (II) and quinic acid lactones (III) to condensate in the presence of dicyclohexylcarbodiimide (DCC) and analog thereof as condensing agent and organic alkali as catalyst to obtain compounds (IV), and hydrolyzing to obtain compounds (I). The condensation reaction is carried out in organic solvent, and hydrolysis is carried out in diluted acid solution or alkali condition such as sodium methoxide and sodium ethoxide. The method has mild reaction condition, simple operation, short step, simple post treatment, and middle to good yield.

Pharmaceutical use of dandelion xylogen acid for inhibiting acetylcholine esterase

The present invention relates to lignin acid which is obtained by being separated from taraxacum plant and the strong activity of the compound of inhibiting acetylcholinesterase. Mongolian taraxacum acid A is prepared by being separated and purified from the taraxacum, which is 6, 9, 10-trihydroxy- xanthene-1, 2-dicarboxylic acid that has obvious inhibiting effect towards the acetylcholinesterase, therefore the compound, officinal salt thereof and medicine combination which is made from the medicine excipient or the carrier allowed by the preparation can be expected with a purpose of being used as a drug for remedying the senile dementia.

Preparation and application of 3,7,10-trimethyl-silatrane Schiff base derivatives

The invention relates to a group of 3,7,10-trimethyl-silatrane Schiff base derivatives, and preparation and application thereof. The preparation method comprises the following steps of: reacting triisopropanolamine with gamma-aminopropyltriethoxysilane to obtain a gamma-amino propyl-3,7,10-trimethyl silatrane intermediate; and then performing a nucleophilic addition reaction of the gamma-amino propyl-3,7,10-trimethyl silatrane intermediate and different substituent-containing aldehyde in benzene solvent to obtain the 3,7,10-trimethyl-silatrane Schiff base derivatives. The 3,7,10-trimethyl-silatrane Schiff base derivatives have high plant growth regulating activity and high anti-inflammatory activity and can be applied to the preparation of a plant growth regulating agent and a cyclooxygenase (COX) inhibitor. The formula is shown as (I) in the specification.

Fire-fighting dispatching management and monitoring method and system

The invention discloses a fire-fighting dispatching management and monitoring method and system, and relates to the technical field of data processing, and the method comprises the steps: collecting basic information of a target region, generating a region duplicated graph, building a dispatching management module comprising a plan decision sub-module and a real-time decision sub-module, receiving alarm receiving event information, and sending the dispatching management module to a cloud server. The plan decision sub-module determines a scheduling decision scheme and a scheduling execution instruction, sends scheduling execution information to a target terminal based on the scheduling decision scheme and the scheduling execution instruction, monitors and coordinates the scheduling decision scheme based on the real-time decision sub-module, generates scheduling adjustment information, and matches the scheduling adjustment information with the target terminal; and performing real-time scheduling ...

Tetrahydrobenzothieno[2,3-d]aminopyrimidine derivatives for FGFR1, and preparation method and application thereof

The invention relates to tetrahydrobenzothieno[2,3-d]aminopyrimidine derivatives acting on FGFR1, and a preparation method and application thereof. The structure of the tetrahydrobenzothieno[2,3-d]aminopyrimidine derivatives is disclosed as Formula (I). The anti-apoptosis experiment research on the three cells H460 (human lung cancer cell), A549 (human lung adenocarcinoma cell) and U251 (glioma cell) indicates that all the detected compounds have certain inhibition activity, and the inhibition activity increases as the concentration increases. Meanwhile, the FGFR1 kinase inhibition activity experiment indicates that the compounds have certain antitumor activity.

3-vinyl-quinoxaline-2(1H)-one derivatives acting on FGFR-1, preparation method and uses thereof

The present invention discloses 3-vinyl-quinoxaline-2(1H)-one derivative acting on FGFR-1, a preparation method and uses thereof, and belongs to the field of pharmaceutical chemistry. According to the present invention, o-phenylenediamine and pyruvic acid are adopted as raw materials and are subjected to cyclization to obtain 3-methyl quinoxaline-2(1H)-one, the 3-methyl quinoxaline-2(1H)-one reacts with different substituted aldehydes to obtain 3-substituted quinoxaline derivatives, and the 3-substituted quinoxaline derivatives are adopted as the intermediate products and are subjected to substitution to obtain other types of the target compounds, wherein the 6 new compounds are prepared; and the 3-vinyl-quinoxaline-2(1H)-one derivatives of the present invention have a certain inhibition effect for experiment cells, show a certain anti-tumor activity, and further have characteristics of cell selectively, good safety, and kinase inhibition activity.

4,6-pyrimidine diamine compound and preparing method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 4,6-pyrimidine diamine compound and a preparing method and an application thereof; the 4,6-pyrimidine diamine compound is an N4,N6-(2,5-dialkoxy phenyl)-pyrimidine diamine compound or an N4-(2,5-dialkoxy phenyl)-N6-(3-alkoxy phenyl)-pyrimidine diamine compound, and in particular, alkoxy can be C1-C4 alkane. The 4,6-pyrimidine diamine compound can be used for broad-spectrum inhibition of the activity of an EGFR kinase and resisting of EGFR expressed tumor cell activity. The EGFR kinase is a wild-type or drug-resistant mutant EGFR kinase, and provides a basis for new drug screening. And the synthesis method of the 4,6-pyrimidine diamine compound provided by the invention is simple in synthesis process and is in favor of industrialized production.

Preparation method and use of piperazine having cytotoxic activity

The invention relates to medicine field, more particularly, a preparation method for piperazine series derivates with body tumour cell cytotoxic activity and the use. By pharmacological activity test, the compounds have substantial inhibition activity for the growth o f 3 tumor cell lines like human prostate cancer cell (PC-3), human nasopharyngeal carcinoma cell (CNE), and human mouth cavity epidermis cancer cell strain, and have antineoplastic pharmaceutical use.