24-05-2012 дата публикации
Номер: US20120129925A1
The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof. 138-. (canceled)40. The compound of claim 39 , wherein Ris methyl claim 39 , ethyl claim 39 , —CHOH claim 39 , or —CHOR′.41. The compound of claim 39 , wherein Ris methyl claim 39 , ethyl claim 39 , —CHOH claim 39 , or —CHOR′.42. The compound of claim 39 , wherein R′ in Ris limited to methyl claim 39 , ethyl claim 39 , propyl or butyl.43. The compound of claim 39 , wherein R′ in Ris limited to methyl claim 39 , ethyl claim 39 , propyl or butyl.44. The compound of claim 39 , wherein R claim 39 , R claim 39 , Rand Rare methyl.45. The compound of claim 39 , wherein Xis H claim 39 , OH claim 39 , R claim 39 , OR claim 39 , —CONH claim 39 , —CONHR′ claim 39 , or —COR′.46. The compound of claim 39 , wherein Xis H claim 39 , OH claim 39 , R claim 39 , OR claim 39 , —CONH claim 39 , —CONHR′ claim 39 , or —COR′.47. The compound of claim 39 , wherein Xis H claim 39 , OH claim 39 , R claim 39 , OR claim 39 , —CONH claim 39 , —CONHR′ claim 39 , or —COR′.48. The compound of claim 39 , wherein R and R′ in one or more of X claim 39 , X claim 39 , and Xare limited to methyl claim 39 , ethyl claim 39 , propyl and butyl.49. The compound of claim 39 , wherein Xis H claim 39 , OH claim 39 , or —OCH.50. The compound of claim 49 , wherein Xis H claim 49 , OH claim 49 , or OCH.51. The compound of claim 44 , wherein Xand Xare independently selected from H and OH.52. The compound of claim 39 , wherein Xis H claim 39 , OH claim 39 , or OCH.53. The compound of claim 39 , wherein Xis H claim 39 , R claim 39 , OH claim 39 , OR claim 39 , COH or COR′.54. compound of claim 51 , wherein Xand Xare independently selected from H claim 51 , methyl claim 51 , ethyl claim 51 , propyl and butyl.55. The compound of claim 51 , wherein Xis H ...
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