Polyester compound

Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.

Method for producing 3-acetylamino-4-hydroxybenzoic acid

The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.

Polyester compound

Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.

THERMOTOLERANT TRANSGLUTAMINASE ORIGINATING IN ACTINOMYCES

The present invention provides transglutaminases with improved heat resistance. Specifically, the present invention provides mutant transglutaminase proteins with improved heat resistance as obtained by introducing appropriate mutations into transglutaminases, which results in the incorporation of a disulfide bond. 1. A protein having transglutaminase activity , and comprising an amino acid sequence selected from the group consisting of:(A) the amino acid sequence of SEQ ID NO: 2, but comprising a mutation at a position selected from the group consisting of the 101-position, 157-position, 250-position, and combinations thereof;(B) the amino acid sequence recited in (A), but comprising a substitution, deletion, addition and/or insertion of one or several residues at a position other than the 101-position, 157-position, and 250-position;(C) the amino acid sequence selected from the group consisting of SEQ ID NO: 4, 6, 8, 10, and 12, but comprising a mutation at a position corresponding to a position in SEQ ID NO: 2 selected from the group consisting of the 101-position, 157-position, 250-position, and combinations thereof;(D) an amino acid sequence which is at least 70% homologous to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, 4, 6, 8, 10, and 12, but comprising a mutation at a position corresponding to a position in SEQ ID NO: 2 selected from the group consisting of the 101-position, 157-position, 250-position, and combinations thereof;(E) the amino acid sequence of (C), but comprising a substitution, deletion, addition and/or insertion of one or several residues at a position corresponding to a position in SEQ ID NO: 2 other than the 101-position, 157-position, and 250-position; and(F) the amino acid sequence of (D), but comprising a substitution, deletion, addition, and/or insertion of one or several residues at a position corresponding to a position in SEQ ID NO: 2 other than the 101-position, 157-position, and 250-position.2. The ...

Polyester compound

Polyester compounds obtained by reaction of a compound represented by formula (1): (defined herein) with a compound represented by formula (2): (defined herein) exhibit high thermal resistance.

POLYESTER COMPOUND

Polyester compounds obtained by reaction of a compound represented by formula (1): 2. A polyester compound according to claim 1 , wherein Xis a phenylene group optionally having a substituent claim 1 , a naphthylene group optionally having a substituent claim 1 , an anthracenylene group optionally having a substituent claim 1 , a furandiyl group optionally having a substituent claim 1 , a pyridinediyl group optionally having a substituent claim 1 , a thiophenediyl group optionally having a substituent claim 1 , or a quinolinediyl group optionally having a substituent.3. A polyester compound according to claim 1 , wherein X is an alkylene group optionally having a substituent claim 1 , a cycloalkylene group optionally having a substituent claim 1 , an alkenylene group optionally having a substituent claim 1 , or an alkynylene group optionally having a substituent.4. A polyester compound according to claim 1 , wherein Z is an alkylene group optionally having a substituent or a single bond.5. A polyester compound according to claim 1 , wherein said compound represented by formula (2) is one or more compounds selected from the group consisting of an alkanediol optionally having a substituent claim 1 , cycloalkanediol optionally having a substituent claim 1 , alkenediol optionally having a substituent claim 1 , alkynediol optionally having a substituent claim 1 , a hydrogenated bisphenol optionally having a substituent claim 1 , polyalkylene glycol optionally having a substituent claim 1 , dialkanolamine optionally having a substituent claim 1 , and an aromatic diol having a hydroxyalkyl group bonded to an aromatic ring and optionally having a substituent.6. A polyester compound according to claim 1 , wherein nis 0 claim 1 , and Xis a phenylene group optionally having a substituent.7. A polyester compound according to claim 1 , whereini) n is 0, X is an alkylene group having 1 to 10 carbon atoms and optionally having a substituent or a cycloalkylene group having 3 to 10 ...

ISOPRENE SYNTHASE AND GENE ENCODING THE SAME, AND METHOD FOR PRODUCING ISOPRENE MONOMER

The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a), (b), or (c): 1. A polynucleotide of the following (a) , (b) , or (c):(a) a polynucleotide comprising (i) the nucleotide sequence represented by SEQ ID NO:1, or (ii) the nucleotide sequence consisting of the nucleotide residues at positions 133 to 1785 in the nucleotide sequence represented by SEQ ID NO:1;(b) a polynucleotide that comprises a nucleotide sequence having 90% or more identity to the nucleotide sequence of (i) or (ii), and encodes a protein having an isoprene synthase activity; or(c) a polynucleotide that hybridizes under a stringent condition with a polynucleotide consisting of the nucleotide sequence complementary to the nucleotide sequence of (i) or (ii), and encodes a protein having an isoprene synthase activity.2Mucuna.. The polynucleotide according to claim 1 , wherein the polynucleotide is derived from3. A protein of the following (A) claim 1 , (B) claim 1 , or (C):(A) a protein comprising (i′) the full length amino acid sequence represented by SEQ ID NO:2, or (ii′) the amino acid sequence consisting of the amino acid residues at positions 45 to 594 in the amino acid sequence represented by SEQ OD NO:2;(B) a protein that comprises an amino acid sequence having 90% or more identity to the amino acid sequence of (i′) or (ii′), and has an isoprene synthase activity; or(C) a protein that comprises an amino acid sequence having a deletion, substitution, addition or insertion of one or several amino acids in the amino acid sequence of (i′) or (ii′), and has an isoprene synthase activity.4. An expression vector comprising the polynucleotide according to .5. A transformant prepared by introducing the expression vector according to into a host.6. The transformant according to claim 5 , wherein the host has an ability to synthesize dimethylallyl diphosphate via a ...

Method for Producing 3-Acetylamino-4-Hydroxybenzoic Acid

The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism. 1. A microorganism that is able to produce 3-amino-4-hydroxybenzoic acid , wherein the microorganism is modified so as to increase formation of 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde , wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity.2. The microorganism according to claim 1 , wherein the N-hydroxyarylamine O-acetyltransferase activity is increased by transformation with a recombinant vector comprising a DNA encoding the NhoA.3. The microorganism according to claim 2 , wherein the NhoA is a protein selected from the group consisting of:(I) a protein comprising the amino acid sequence of SEQ ID NO:2;(II) a protein comprising an amino acid sequence having one or several amino acid substitutions, deletions, insertions or additions in the amino acid sequence of SEQ ID NO:2 and having an N-hydroxyarylamine O-acetyltransferase activity; and(III) a protein comprising an amino acid sequence having 70% or more identity to the amino acid sequence of SEQ ID NO:2 and having an N-hydroxyarylamine O-acetyltransferase activity.4. The microorganism according to claim 2 , wherein the DNA encoding the NhoA is a DNA selected from the group consisting of:(i) a DNA comprising the nucleotide ...

COSMETIC COMPOSITION

A method for perming or coloring hair, in which hair is treated with a cosmetic composition including a protein-glutaminase and not including an alkaline substance. A method of enhancing hair-permeation of an active ingredient included in a cosmetic composition, in which a protein glutaminase is included in the cosmetic composition. The cosmetic composition does not include an alkaline substance, and the active ingredient is at least one of a hair perm agent and a hair coloring agent. 121-. (canceled)22. A method for perming or coloring hair , comprising:treating hair with a cosmetic composition,wherein the cosmetic composition comprises a protein-glutaminase and does not comprise an alkaline substance.23. The method of claim 22 , wherein the cosmetic composition further comprises at least one of a hair perm agent and a hair coloring agent.24. The method of claim 22 , wherein the protein-glutaminase has a molecular weight of 10 kDa to 40 kDa.25. The method of claim 22 , wherein the cosmetic composition comprises 0.00001 to 10 mass % of the protein-glutaminase claim 22 , based on the total mass of the cosmetic composition.26Chryseobacterium.. The method of claim 22 , wherein the protein-glutaminase is derived from a bacterium belonging to the genus27. The method of claim 22 , wherein the cosmetic composition further comprises a transglutaminase.28. The method of claim 27 , wherein the cosmetic composition comprises 0.001 to 2 mass % of the transglutaminase claim 27 , based on the total mass of the composition.29. The method of claim 27 , wherein a mass ratio of the protein-glutaminase to the transglutaminase in the cosmetic composition is from 1:1 to 1:10000.30. The method of claim 22 , wherein the cosmetic composition further comprises a further component selected from the group consisting of an amino acid claim 22 , an acylamino acid claim 22 , an acylamino acid ester claim 22 , an acylamino acid amide claim 22 , a peptide claim 22 , an acylpeptide claim 22 , a ...

RISK-OF-FALLING DETERMINATION APPARATUS, RISK-OF-FALLING DETERMINATION METHOD, RECORDING MEDIUM, AND OUTPUT APPARATUS

A risk-of-falling determination apparatus includes a walk information obtainer that obtains walk information of a user, a myoelectric sensor that measures a first myoelectric potential difference on an anterior surface of a thigh of the user and a second myoelectric potential difference on a posterior surface of the thigh, a control circuit that identifies an interval of a stance phase by using the walk information, calculates a degree of co-contraction at a corresponding leg of the user on the basis of the first and second myoelectric potential differences for the stance phase, and determines whether the degree of co-contraction is greater than or equal to a first threshold, and an outputter that outputs a signal indicating that the user has a high risk of falling if the degree of co-contraction is greater than or equal to the first threshold. 1. A risk-of-falling determination apparatus comprising:a walk information obtainer that obtains walk information of a user for a predetermined time interval;a myoelectric sensor that measures a first myoelectric potential difference by using first electrodes disposed on an anterior surface of a thigh of a leg of the user and measures a second myoelectric potential difference by using second electrodes disposed on a posterior surface of the thigh of the leg of the user, the first myoelectric potential difference being a myoelectric potential difference on the anterior surface of the thigh, the second myoelectric potential difference being a myoelectric potential difference on the posterior surface of the thigh;a control circuit that(i) identifies an interval of a stance phase in the predetermined time interval by using the walk information of the user, the interval of the stance phase being an interval for which a foot of the leg of the user is in contact with ground,(ii) calculates a degree of co-contraction at the leg of the user by using the first myoelectric potential difference for the interval of the stance phase and ...

POLYAMIDE COMPOUND

Polyamide compounds obtained by reacting a compound represented by formula (1): 2. The polyamide compound according to claim 1 , wherein Xis a phenylene group optionally having a substituent claim 1 , a naphthylene group optionally having a substituent claim 1 , an anthracenylene group optionally having a substituent claim 1 , a frandiyl group optionally having a substituent claim 1 , a pyridinediyl group optionally having a substituent claim 1 , a thiophenediyl group optionally having a substituent claim 1 , a quinolinediyl group optionally having a substituent claim 1 , an alkylene group optionally having a substituent claim 1 , a cycloalkylene group optionally having a substituent claim 1 , an alkenylene group optionally having a substituent claim 1 , a cycloalkenylene group optionally having a substituent claim 1 , an alkynylene group optionally having a substituent claim 1 , or a divalent non-aromatic heterocyclic group having an oxygen atom as a heteroatom constituting the heterocyclic ring and optionally having a substituent.3. The polyamide compound according to claim 1 , wherein Xis an alkylene group optionally having a substituent or a cycloalkylene group optionally having a substituent.4. The polyamide compound according to claim 1 , wherein Zis an alkylene group optionally having a substituent claim 1 , a cycloalkylene group optionally having a substituent claim 1 , or a single bond.5. The polyamide compound according to claim 1 , wherein nis 0 claim 1 , and Xis a phenylene group optionally having a substituent.6. The polyamide compound according to claim 1 , wherein:{'sup': Da', 'Da, 'i) nis 0, and Xis an alkylene group having 1 to 15 carbon atoms, and optionally having a substituent, or a cycloalkylene group having 3 to 10 carbon atoms and optionally having a substituent; or'}{'sup': Da', 'Da', 'Da', 'Da, 'ii) nis 1 or 2, Xis an alkylene group, having 1 to 6 carbon atoms, and optionally having a substituent, or a cycloalkylene group, having 3 to 10 ...

COSMETIC COMPOSITION

The problem of the present invention is to provide a protein hydrophilicity-increasing agent capable of effectively increasing water permeability of (swelling) hair, skin and the like while suppressing damages on the hair, skin and the like constituted of the protein. 1. A cosmetic composition , comprising at least one protein-glutaminase.2. A cosmetic composition according to claim 1 , claim 1 , wherein said at least one protein-glutaminase has a molecular weight of 10 to 40 kDa.3. A cosmetic composition according to claim 1 , which comprises said at least one protein-glutaminase in an amount of 0.00001 to 10 mass % claim 1 , based on the total mass of the composition.4. A cosmetic composition according to claim 1 , wherein said at least one protein-glutaminase is derived from a bacterium belonging to the genus Chryseobacterium.5. A cosmetic composition according to claim 1 , further comprising at least one transglutaminase.6. A cosmetic composition according to claim 5 , which comprises said at least one transglutaminase in an amount of 0.001 to 2 mass % claim 5 , based on the total mass of the composition.7. A cosmetic composition according to claim 5 , wherein said at least one protein-glutaminase and said at least one transglutaminase are present in a mass ratio claim 5 , glutaminase:transglutaminase claim 5 , of from 1:1 to 1:10000.8. A cosmetic composition according to claim 1 , further comprising at least one further component selected from the group consisting of an amino acid claim 1 , an acylamino acid claim 1 , an acylamino acid ester claim 1 , an acylamino acid amide claim 1 , a peptide claim 1 , an acylpeptide claim 1 , and a salt thereof.9. A cosmetic composition according to claim 8 , which comprises said at least one further component in an amount of 0.005 to 50 mass % claim 8 , based on the total mass of the composition.10. A cosmetic composition according to claim 1 , further comprising at least one alcohol.11. A cosmetic composition according to ...

Production of alkali metal cyclopentadienylides and production of dihalobis(eta-substituted-cyclopentadienyl) zirconium from alkali metal cyclopentadienylides

process for producing transglutaminase.

非水電解液及び非水電解液二次電池

(57)【要約】 【課題】 安全性が高く、低温特性に優れ、かつ電池充 放電性能の優れた非水電解液および該非水電解液を含む 二次電池を提供すること。 【解決手段】 電解質と、エチレンカーボネート(EC)と プロピレンカーボネート(PC)およびジエチルカーボネー ト(DEC)とを含む混合溶媒とからなり、かつエチレンカ ーボネートとプロピレンカーボネートとの混合体積比率 (EC:PC)が、10:1〜10:8である非水電解液。前記非水電 解液と、リチウムイオンのドープ・脱ドープが可能な炭 素材料を負極活物質として含む負極と、リチウムと遷移 金属の複合酸化物を正極活物質として含む正極と、セパ レータとからなる非水電解液二次電池。

Production of alkali metal cyclopentadienylide and production of dihalobis (η-substituted-cyclopentadienyl) zirconium from alkali metal cyclopentadienylide

A process for producing an alkali metal cyclopentadienylide is disclosed which comprises reacting in a solvent an alkali metal hydride with a disubstituted or trisubstituted 1,3-cyclopentadiene. Further, a process for producing a dihalobis(η-substituted-cyclopentadienyl)zirconium is disclosed which comprises reacting a zirconium halide with the above alkali metal cyclopentadienylide. The former process enables performing the reaction between the disubstituted or trisubstituted 1,3-cyclopentadiene and the alkali metal hydride at an easily controllable temperature of room temperature to about 150° C. and also enables obtaining the alkali metal cyclopentadienylide in high yield. The latter process enables obtaining the dihalobis(η-substituted-cyclopentadienyl)zirconium in high yield.

アルカリ金属シクロペンタジエニリド類の製造方法およびアルカリ金属シクロペンタジエニリド類を用いるジハロビス（η―置換シクロペンタジエニルジルコニウム類の製造方法

(57)【要約】 （修正有） 【解決手段】2または3置換の1,3-シクロヘ゜ンタシ゛エン類と水素 化アルカリ金属とを溶媒中で反応させる一般式IIのアルカリ金属 シクロヘ゜ンタシ゛エニリト゛類の製造方法。また、これとハロケ゛ン化シ゛ル コニウムとを反応させるシ゛ハロヒ゛ス(η- 置換シクロヘ゜ンタシ゛エニル)シ゛ル コニウム類の製造方法。 ［Ｒ １ およびＲ ２ は独立にＣ１〜８のアルキル基、Ｃ６ 〜１０のアリール基、Ｃ２〜８のアルケニル基またはＣ ７〜９のアラルキル基、Ｒ ３ は水素またはＣ１〜３のア ルキル基である］ 【効果】制御し易い室温〜150℃で反応させ、アルカリ金属シ クロヘ゜ンタシ゛エニリト゛類を高収率で得ることができる。

Pyrrolo(2,3-d)pyrimidine derivative

Novel pyrimidine derivative

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Isoprene synthase, polynucleotides encoding the same, and methods for producing isoprene monomer

【課題】優れたイソプレンモノマー生産系の確立に有用な手段の提供。 【解決手段】以下（ａ）、（ｂ）または（ｃ）のポリヌクレオチドなど：（ａ）（ｉ）特定の塩基配列、もしくは（ｉｉ）特定の塩基配列中の１３３〜１７８５番目のヌクレオチド残基からなる塩基配列を含むポリヌクレオチド；（ｂ）前記（ｉ）もしくは（ｉｉ）の塩基配列と９０％以上の同一性を有する塩基配列を含み、かつイソプレンシンターゼ活性を有するタンパク質をコードするポリヌクレオチド；または（ｃ）前記（ｉ）もしくは（ｉｉ）の塩基配列と相補的な塩基配列からなるポリヌクレオチドとストリンジェントな条件下でハイブリダイズし、かつイソプレンシンターゼ活性を有するタンパク質をコードするポリヌクレオチド。 【選択図】なし

Novel alpha-chloroketone derivative and production thereof

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Prepataion of substituted nitrile

Fluorine-substituted cyclic carbonate and electrolytic solution and battery containing the same

Monofluoromethylethylene carbonate, difluoromethylethylene carbonate and trifluoromethylethylene carbonate, each being a novel compound that is chemically and physically stable, has a high permittivity, can well dissolve organic substances, and can be used in a wide temperature range, thus being useful as a solvent. Further these compounds are excellent in withstand voltage and charge-discharge cycle characteristics as a nonaqueous electrolyte solution, have a high flashing point and an excellent safety, and can provide batteries excellent in withstand voltage and charge-discharge cycle characteristics.

Indan derivatives

Discloses indan derivatives represented by the general formula (I): (I) wherein R is a lower alkoxy group, a phenoxy group,

Ionically conductive polymeric gel electrolyte and solid battery containing the same

An ionically conductive polymeric gel electrolyte comprising a polymer matrix, a non-aqueous electrolytic solution and an electrolytic salt, wherein the solvent of the non-aqueous electrolytic solution comprises a halogen-substituted carbonic ester.

Quinazoline derivatives and antihypertensive preparations containing same as effective components

Abstract of the Disclosure Disclosed herein is an antihypertensive preparation containing, as an active component, a novel quinazoline derivative represented by the following general formula or a salt thereof:

Method for the sectetion and production of protein

The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete (secreto-production) an industrially useful heterologous protein. According to the present invention, a genetic construct is used where a gene sequence encoding an intended protein which is ligated to the downstream of a sequence encoding the signal peptide derived from a coryneform bacterium, the gene construct is introduced into a mutant coryneform bacterium which has a capacity of secreting the heterologous protein at least 2-fold higher than the wild type Corynebacterium glutamicum ATCC13869, the mutant coryneform bacterium is cultured and the extracellularly released heterologous protein is recovered.

Cell electrolyte solvent, cell electrolyte comprising the solvent and non-aqueous electrolyte battery comprising the electrolyte

Disclosed are a solvent for cell electrolyte comprising a carbamate represented by the following formula [1]; ##STR1## wherein R 1 , R 2 and R 3 independently represent a linear or branched alkyl group, cell electrolyte and non-aqueous electrolyte battery comprising the solvent. The solvent can provide batteries showing high withstand voltage and excellent charge/discharge efficiency.

Quinazoline derivative and pharmaceutical use

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for the secretion and production of protein

Novel alpha-chloroketone derivative and process for preparation thereof

Disclosed is a novel alpha-chloroketone derivative as a synthesis intermediate of N-cyano-N'methyl-N"-(2-((5-methyl-1H-imidazol-4-yl)-methylthio)ethyl)guanidine (general name: Cimetidine) which shows an action of controlling the secretion of gastric acid and is valuable as a medicine for remedy of a gastric ulcer. This alpha-chloroketone derivative is prepared by reacting a disulphide derivative with sulphuryl chloride and reacting the reaction product with methylvinyl ketone or by reacting a mercapto derivative with 3-chloro-3-buten-2-one.

Novel amines and their use

Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

Processed fiber product, and method for production thereof

A processed fiber product having excellent strength, water-absorbability and washing durability can be produced by attaching a partially hydrolyzed product of a wheat protein to a fiber and then allowing a transglutaminase to act on the fiber.

Mutant transglutaminase from streptoverticillium having modified substrate specificity

The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying MTG on the basis of the three-dimensional structure, and transglutaminase having reactivity on the substrate improved by the method. In the present invention, the binding site of MTG for the substrate is extrapolated based on the three-dimensional structure obtained by X-ray crystal structure analysis of MTG crystals, and the mutant transglutaminases are designed and produced by replacing, inserting or deleting amino acid residues positioned at the substrate-binding site of the transglutaminase.

Novel carbonate compounds, non-aqueous electrolytic solutions and batteries comprising non-aqueous electrolytic solutions

A novel carbonate compound represented by the general formula [I]: R1CH2O-CO-OCH2R2 [I] wherein R1 represents a hydrogen atom, an alkyl group or an alkyl group substituted with one or more halogen atoms, and R2 represent an alkyl group having no hydrogen atom at the .alpha.-position thereof or an alkyl group substituted with one or more halogen atoms having no hydrogen atom at the .alpha.-position thereof, with the proviso that R1 is not identical to R2, which has excellent properties as solvent, is disclosed. A non-aqueous electrolytic solution and a battery utilizing the novel carbonate compound are also disclosed.

Pyrimidines or their pharmaceutically acceptable salts thereof

Compounds of formula <CHEM> where X is -NR<1>R<2> or SR<4>; Y is amino optionally substituted by alkyl; Z is methyl substituted by alkoxy carbonyl or alkoxycarbonyl or Y and Z together may form a divalent group -X-Y- of formula <CHEM> . The compounds are useful in the treatment if neurological diseases of the pheripheral and central nervous systems of animals.

Indan derivatives

Method of producing polysilane compounds

A method of producing a polysilane compound which comprises polymerizing a monomeric silane of general formula <CHEM> wherein each R independently represents hydrogen or a hydrocarbon group provided that both R's are not hydrogen, in the presence of an organometallic complex of, as metal, Ni, Co, Ru, Pd or Ir.

Process for Preparation of Transglutaminase

Non-aqueous electrolytic solutions and non-aqueous electrolyte cells comprising the same

A non-aqueous electrolytic solutions which has self-distinguishing property, low reactivity to metal lithium and high withstand voltage is provided. The non-aqueous electrolytic solutions of the first invention comprise, as electrolyte, lithium salt preferably LiPF6 and, as solvent, phosphoric acid esters of the following general formula [1]; [1] wherein R1, R2 and R3, which may be the same or different, represent an alkyl group or an alkyl group substituted by one or more halogen atoms and at least one of R1, R2, and R3 represents an alkyl group substituted by one or more halogen atoms. The non-aqueous electrolytic solutions of the second invention comprise, as solvents for electrolyte, trimethyl phosphate, one or more linear carbonates represented by the following general formula [3]; [3] (wherein R6 represents methyl or ethyl group and R7 represents a linear or branched alkyl group having 1 to 3 carbon atoms) and one or more cyclic carbonates and, as electrolyte, LiPFe; wherein content of the trymetyl phosphate is 1 to 10 % by volume of the solvents for electrolyte. The non-aqueous electrolytic solution is suitable for a cell using carbon material capable of being doped and dedoped with lithium ions as a negative electrode active material and complexed oxide of lithium and a transition metal as a positive electrode active material.

Information processing system, information processing apparatus, information processing method, recording medium and programm

A CD-R(2) where a key generating program or the like is stored, and a USB memory(4) where a public key(6) is stored are delivered to a supplier(3) from a receiver(1). A common key(7) is generated by the supplier(3). Delivery data which is to be encrypted using the generated common key(7) and a common key(7) which is encrypted using the public key(6) are stored in the CD-R(2) by the supplier(3). The CD-R(2) and the USB memory(4) are delivered to the receiver(1) by the supplier(3). The encrypted common key(7) is decrypted by the receiver(1) using a private key(5). The encrypted delivery data is decrypted by the receiver(1) using the decrypted common key(7).

Process for producing transglutaminase

Water absorbent resin, absorbent body, absorbent article, and production method for water absorbent resin

A water-absorbent resin (21) has a shape in which a plurality of particles (40) having a substantially spherical shape is connected in a chain shape.

Process for producing transglutaminase

Process for Removal of Diol as Impurity in Cyclic Carbonic Acid Ester

A process for removing a diol from a cyclic carbonic acid ester containing the diol as an impurity, which comprises bringing a cyclic carbonic acid ester containing a diol as an impurity into contact with a synthetic zeolite in the presence of a chain carbonic acid ester. According to this process, there can be obtained a mixture of a cyclic carbonic acid ester and a chain carbonic acid ester having a very small content of diol, which is suitable as a solvent for electrolytic solution of a condenser, cell or battery.

Carbonate compounds, non-aqueous electrolyte solutions and batteries containing non-aqueous electrolyte solutions

Method for producing an angiotensin converting enzyme inhibitor-containing composition

Disclosed is a method for producing an angiotensin converting enzyme inhibitor composition from natural materials, which composition is of use as an antihypertensive drug or diet. The method comprises heating a meat in water at a temperature not lower than 50° C. to extract water-soluble protein and hydrolyzing the residue predominantly composed of water-insoluble protein with a protease.

Method of producing microbial transglutaminase

It is intended to provide an actinomyces-origin neutral metalloprotease, which selectively cleaves the pro-structure moiety of a microorganism-origin protransglutaminase, and a gene encoding the same. An activated microorganism-origin transglutaminase from which the pro-structural moiety has been excised can be produced by culturing a microorganism having the gene encoding the above-described actinomyces-origin neutral metalloprotease transferred thereinto, allowing the microorganism to produce the actinomyces-origin neutral metalloprotease and then treating the microorganism-origin protransglutaminase therewith.

Quinazoline derivative, and hypotensor containing said derivative as active component

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for producing microbial transglutaminase

Preparation of 3-(2,4,6-triisopropylbenzoyl)acrylic acid

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Preparation of Alkali Metal Cyclopentendiene Compounds, and Preparation of Zirconocenes with this Compound

Fluorine-substituted cyclic carbonate electrolytic solution and battery containing the same

PCT No. PCT/JP96/01515 Sec. 371 Date Feb. 6, 1997 Sec. 102(e) Date Feb. 6, 1997 PCT Filed Jun. 5, 1996 PCT Pub. No. WO96/41801 PCT Pub. Date Dec. 27, 1996Monofluoromethyl ethylene carbonate, difluoromethyl ethylene carbonate and trifluoromethyl ethylene carbonate are provided as novel compounds. These compounds are very useful as solvents because they are chemically and physically stable, have a high dielectric constant, can dissolve well organic substances and have a wide application temperature range. These compounds are excellent in charge and discharge cycle characteristics, have a high flash point, and are safe as non-aqueous elecytrolytes and hence, batteries using these compounds are excellent in withstand voltage and charge and discharge cycle characteristics.

Isoprene synthase and polynucleotide encoding same, and method for producing isoprene monomer

Method for producing an angiotensin converting enzyme inhibitor-containing composition

A method of producing an angiotensin converting enzyme inhibitor-containing composition, which is of value as an antihypertensive agent or diet, from natural resources. According to the method, proteins are hydrolyzed with a protease elaborated by a microorganism of the genus Bacillus, Aspergillus or Rhizopus or a protease of papaya origin.

Multilayer metallized film capacitor

(57)【要約】 【課題】 従来の積層形メタライズドフィルムコンデン サに比較し、大幅に耐湿性能が向上した積層形メタライ ズドフィルムコンデンサを提供すること。 【解決手段】 複数枚のメタライズドフィルムを積層し た積層体の４面の積層側面の内対向する両積層側面にメ タリコン金属電極１４を形成すると共に、低粘度樹脂を 含浸・硬化させ、更に外表面に粉体樹脂外装２１を施し てなる積層形メタライズドフィルムコンデンサにおい て、積層体のメタリコン金属電極１４を形成した側面を 除く積層側面を多孔質シートを巻回してなる多孔質シー ト巻回層１７で覆い、該多孔質シート巻回層１７及びメ タリコン金属電極１４で覆われた積層体に低粘度樹脂を 含浸・硬化させ、外表面に粉体樹脂外装２１を施した。 これにより積層側面が樹脂の含浸・硬化した多孔質シー ト巻回層１７で覆われることになり、耐湿性能が向上す る。

Method of denaturing protein with enzymes

Thermotolerant transglutaminase originating in actinomyces

Cyanoguanidine derivative and process for preparation thereof

CYANOGUANIDINE DERIVATIVE AND PROCESS FOR PREPARATION THEREOF Abstract Or the Disclosure The present invention provides a cyanoguanidine derivative which is a precursor for the synthesis of N-cyano-N'-methyl-N"-(2-{(5-methyl-1H-imidazol-4-yl)methylthio}ethyl)-guanidine (Cimetidine) or its related compound, which has an action of controlling secretion of acid in the stomach based on the histamine H2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting other cyanoguanidine derivative with a halogenating agent.

Novel allyl ethers, polymers and polymeric solid electrolytes

Method of denaturing protein with enzymes

A method of denaturing a protein by treating the protein with a protein glutaminase and a transglutaminase, a food containing a protein having been denatured with these enzymes, and an enzyme preparation for denaturing a protein which contains these enzymes. A protein is denatured by adding protein glutaminase and transglutaminase to the protein substantially at the same timing, or adding protein glutaminase to the protein before the transglutaminase acts on the protein, or controlling the quantitative ratio of protein glutaminase to transglutaminase, by which a protein is treated, to a definite level.

Isotopic tagging of protein by enzyme

(57)【要約】 【課題】 タンパク質のアミノ酸残基の官能基を同位体 標識する方法を提供すること、および、アミノ酸残基の 官能基が同位体標識されたタンパク質を提供すること。 【解決手段】 酵素の作用によりタンパク質のアミノ酸 残基の官能基を同位体標識化合物に由来する同位体標識 基で置換する。特に、同位体標識化合物の存在下でタン パク質のグルタミン残基にトランスグルタミナーゼを作 用させ、そのグルタミン残基のカルボキシアミド窒素を 同位体標識基で置換する。

Thioxopyridopyrimidine derivative

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for producing transglutaminase

Transglutaminase having an enzymatic activity is produced by subjecting transglutaminase which is in a denatured state to a process involving at lea st the following steps (a) and (b): (a) the step of forming an intermediate structure, which shows the enzymatic activity in an aqueous medium under acidic conditions, of the denatured enzyme in the course of forming the structure; and (b) the step of forming a higher-order structure, which shows the enzyme activity in an aqueous medium at a pH value within the neutral region, of the enzyme having the intermediate structure in the course of forming the structure as described above. Thus, transglutaminase obtained in a denatured state (for example, one produced by a gene recombinant microorganism) can be efficiently refolded and, therefore, highly pure transglutaminase having an enzymatic activity substantially comparable to th e activity of authentic transglutaminase (i.e., transglutaminase activity) can be industrially produced. The intermediate having the intermediate structure in the course of forming the structure as described above.

Method of modifying microorganism-origin transglutaminase

Method of modifying microorganism-origin transglutaminase

A method of designing and constructing a variant transglutaminase originating in Streptoverticillium mobaraense based on the stereo-structure of MTG and the variant MTG thus constructed. Thus, a method of modifying MTG based on its stereo-structure and a transglutaminase having been thus improved in the reactivity with the substrate are provided. In the above method, the variant transglutaminase is designed and constructing by estimating the binding site of MTG to the substrate based on the stereo-structure obtained by X-ray analyzing the crystalline structure of MTG crystals, and substituting, inserting or deleting the amino acid residue located at the substrate-binding site of the transglutaminase.

METHOD FOR MODIFYING A PROTEIN, FOOD, ENZYME PREPARATION FOR MODIFYING A PROTEIN, AND METHOD FOR ESTABLISHING AN OPTIMAL PROTEIN GLUTAMINASE RELATION FOR TRANSGLUTAMINASE

Method of producing microbial transglutaminase

The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.

Process for efficiently producing transglutaminase through DNA recombination

The present invention relates to a process for producing a transglutaminase, which comprises incubating Escherichia coli expressing genes encoding a heat shock protein (DnaJ) and a transglutaminase. The transglutaminase is produced in large quantities, at low cost and has the appropriate stereostructure to render the transglutaminase biologically active. The transglutaminase so produced is useful in the food industry.

Novel carbonate compounds, non-aqueous electrolytic solutions and batteries comprising nonaqueous electrolytic solutions

A carbonate compound of formula (I):         R¹CH₂-O-CO-O-CH₂R²   (I) wherein: R¹ is a hydrogen atom, an alkyl group or an alkyl group substituted with one or more halogen atoms; and R² is an alkyl group having no hydrogen atom at the α-position thereof or an alkyl group substituted with one or more halogen atoms and having no hydrogen atom at the α-position thereof; with the proviso that R¹ is not identical to R².

Process for producing microbial transglutaminase

Disclosed are a protein having a transglutaminase activity, which comprises a sequence ranging from serine residue at the second position to proline residue at the 331st position in an amino acid sequence represented by SEQ ID No. 1 wherein the N-terminal amino acid of the protein corresponds to serine residue at the second position of SEQ ID No. 1, a DNA encoding the protein, a transformant having the DNA, and a process for producing a protein having a transglutaminase activity, which comprises the steps of culturing the transformant in a medium. The protein can be produced in a large amount with the transformant using a host such as E. coli.

Method of denaturing protein with enzymes

PROVIDED ARE: A METHOD OF DENATURING A PROTEIN BY TREATING THE PROTEIN WITH BOTH OF PROTEIN GLUTAMINASE AND TRANSGLUTAMINASE; A FOOD CONTAINING A PROTEIN HAVING BEEN DENATURED WITH THESE ENZYMES; AN ENZYME PREPARATION FOR DENATURING A PROTEIN WHICH COMPRISES THESE ENZYMES; AND A METHOD OF ESTABLISHING AN OPTIMUM QUANTITATIVE RATIO OF PROTEIN GLUTAMINASE TO TRANSGLUTAMINASE BOTH OF WHICH ARE TO BE ADDED TO A PROTEIN. A PROTEIN IS DENATURED BY ADDING PROTEIN GLUTAMINASE AND TRANSGLUTAMINASE TO THE PROTEIN SUBSTANTIALLY AT THE SAME TIMING, OR ADDING PROTEIN GLUTAMINASE TO THE PROTEIN BEFORE THE TRANSGLUTAMINASE ACTS ON THE PROTEIN, OR CONTROLLING THE QUANTITATIVE RATIO OF PROTEIN GLUTAMINASE TO TRANSGLUTAMINASE, BY WHICH A PROTEIN IS TREATED, TO A DEFINITE LEVEL. THE OPTIMUM QUANTITATIVE RATIO OF PROTEIN GLUTAMINASE TO TRANSGLUTAMINASE, BOTH OF WHICH ARE TO BE ADDED TO A PROTEIN, IS DETERMINED BASED ON THE NMR SIGNAL INTENSITY OF THE PROTEIN LABELED WITH ISOTOPE-LABELED AMMONIUM OR THE LIKE.

Method for isotope labeling of protein with enzyme

The present invention provides a method for isotopically labeling a functional group possessed by an amino acid residue of a protein. The present invention also provides a protein whose functional group in an amino acid residue is isotopically labeled. A functional group in an amino acid residue of a protein is substituted with an isotope-labeling group derived from an isotope-labeling compound by making use of the action of an enzyme. In particular, the carboxyamide nitrogen atom in a glutamine residue of a protein is replaced with an isotopically labeled atom by acting a transglutaminase on the glutamine residue.

Therapeutic agent of neurological diseases

ABSTRACT A pharmaceutical composition comprising a pyrimidine represented by the following formula

Verfahren zur sekretion und produktion von protein

Verfahren zur herstellung von transglutaminase

有色飲料排水の脱色方法及び脱色装置

【課題】汚泥を発生させることなく、有色飲料排水を効率的に脱色する。 【解決手段】有色飲料排水に酸化剤を添加して混合することにより有色飲料排水中の有色成分を酸化脱色させた後、触媒で処理することによって脱色を促進させる有色飲料排水の脱色方法。混合手段３１を備える調整槽１１と、調整槽１１に酸化剤を添加する酸化剤添加手段と、調整槽１１からの流出水が導入される触媒塔１３とを備える有色飲料排水の脱色装置。 【選択図】 図１

医薬用組成物

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Carbonizing device, carbonizing system, and carbonizing method

Method for isotope labeling of protein with enzyme

The present invention provides a method for isotopically labeling a functional group possessed by an amino acid residue of a protein. The present invention also provides a protein whose functional group in an amino acid residue is isotopically labeled. A functional group in an amino acid residue of a protein is substituted with an isotope-labeling group derived from an isotope-labeling compound by making use of the action of an enzyme. In particular, the carboxyamide nitrogen atom in a glutamine residue of a protein is replaced with an isotopically labeled atom by acting a transglutaminase on the glutamine residue.

Fremgangsmåde til isotopmærkning af protein med enzym

Enzymatisches Verfahren zur Markierung von Proteinen mit Isotopen

β−アロイルアクリル酸の製法

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Novel polyalkyl-hydroxy-substituted methylindane

向精神薬

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Verfahren zur herstellung mikrobieller transglutaminase

イミダゾ−ル誘導体の製造方法

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

画像処理方法および装置

【課題】画像に二次元コード情報を視認できないように埋込むことができる画像処理方法および画像処理装置を提供する。 【解決手段】画像処理装置（１００）は、二次元コードデータを入力画像サイズ以内の所定領域に拡散させた二次元コード拡散データを生成する二次元コードデータ拡散処理部（１０１）と、二次元コード拡散データを入力画像データの対応ピクセルに埋め込むことで合成画像を生成する合成部（二値化処理部１０２、比較部１０３、画像加工部１０４）と、を有する。 【選択図】図２

Novel (meth)acrylates and methods of producing thereof

The invention provides a (meth)acrylate represented by the general formula (I) wherein X is a single bond or an alkylidene group having the general formula (II) wherein R 3 and R 4 are independently hydrogen atoms or alkyl groups having 1 to 4 carbon atoms, R 1 is a hydrogen atom or a methyl group, R 2 is an alkyl group having 1 to 4 carbon atoms, m is 0 or 1, and when m is 0, n is 3, and when m is 1, n is 0. The (meth)acrylate is obtained by reacting a cycloaliphatic ketone, an organomagnesium halide and a (meth)acrylic acid ester in the presence of an amine under the industrially feasible reaction conditions and operation according to the invention.

リンガー信号検出回路、ループ生成回路、および電話線用信号変換回路

(57)【要約】 【課題】 回路の小形化ならびに低コスト化が可能なリ ンガー信号検出回路とループ生成回路とを提供する。 【解決手段】 リンガー信号検出回路１０において、リ ンガー信号を入力としてその検出結果をＨまたはＬのリ ンガー検出信号ＯＵＴ１として出力する比較機能部を、 既存のＴＴＬまたはＣＭＯＳバッファにより実現する。 またループ生成回路２０において、ループを形成する第 １および第２トランジスタ回路（ＴＲ１〜ＴＲ４）の間 に抵抗Ｒ３０を設け、この両端にループ制御トランジス タＴＲ５を接続し、ループ閉信号ＩＮ１によりこれをオ ン／オフする。

エッジ・ブロードバンド・アクセス中継装置およびブロードバンドネットワークシステム

(57)【要約】 【課題】ブロードバンドネットワークシステムにおける 中継網の負荷を低減することを目的とする。 【解決手段】電気通信事業者（ＩＳＰ）のサーバーに接 続された基幹通信網とユーザ端末が接続している加入者 網とを中継網を介して接続するエッジ・ブロードバンド ・アクセス中継装置において、予めユーザＩＤとパスワ ードとを一意的に設定しておく第一のテーブルと予めＩ ＳＰとＶＬＡＮ（ＶｉｒｔｕａｌＬｏｃａｌ Ａｒｅａ Ｎｅｔｗｏｒｋ）タグ番号とを一意的に設定しておく第 二のテーブルとを有するデータベース部と、ユーザの端 末から送信されるデータからユーザＩＤとパスワードと 送信元イーサネット（登録商標）アドレスとを抽出する 抽出部と、前記パスワードの認証とＩＳＰに対応するＶ ＬＡＮタグ番号の識別とを行う選択部と、該選択部の指 示に基づきイーサネットフレームへのＶＬＡＮタグ付加 ／削除をする操作部と、データを各端末毎に振分けるス イッチ部とを備える。

情報処理装置、情報処理方法及び情報処理プログラム

【課題】事象が異常か否かの判定することが可能な情報処理装置、情報処理方法及び情報処理プログラムを提供する。 【解決手段】情報処理装置は、画像データを受け付ける受付部と、事象の任意の第１状態を学習した第１学習モデルと、受付部によって受け付けた画像データとに基づいて、画像データに記録される事象と第１学習モデルに基づく第１状態との乖離度を取得する取得部と、第１状態とは異なる、少なくとも事象の複数の第２状態を学習した第２学習モデルと、受付部によって受け付けた画像データとに基づいて、画像データに記録される事象を複数の状態に分類に分類する分類部と、取得部によって取得される乖離度と、分類部によって分類された結果とに基づいて、画像データに記録される事象の状態を出力部から出力する出力制御部と、を備える。 【選択図】図１

検出装置、生成装置、検出システム、検出方法及び検出プログラム

【課題】より小規模な符号生成回路でビットエラーの検出を可能にする検出装置等の提供。【解決手段】検出装置は、データ経路を介して第一受信された第一排他的論理和と前記データ経路を介して第二受信された第二情報又は前記第二情報から導かれる情報との第二排他的論理和を生成する受信側排他的論理和生成部と、前記データ経路を介して第三受信された第一情報の前記第二排他的論理和による検査に係る検査結果を出力する出力部と、を備え、前記第一排他的論理和の各データが、前記第三受信に係る送信の前の前記第一情報から生成された冗長コードと、前記第二受信に係る送信の前の前記第二情報又は前記第二受信に係る送信の前の前記第二情報から導かれる情報と、により生成されたものである。【選択図】 図４

Selective molecular excitation method and isotope separation method using the same, isotope analysis method, selective molecular excitation apparatus and isotope separation apparatus

Molecules of a specific species can be selectively excited among molecules of a plurality of species that show only a slight difference of mass. Energy levels can be displayed on a graph where the horizontal axis indicates excitation energy. Assume an instance where an electromagnetic wave showing a comb-shaped spectrum having a plurality of narrow bands as indicated by P 1 through P 14 and tuning with excitation energies corresponding to the rotational levels of molecule X is irradiated onto the molecule X. The molecule X can sequentially make transitions to higher energy levels by using an electromagnetic wave showing such a comb-shaped spectrum. The energy levels of molecule Y are not synchronized with the comb-shaped spectrum. The two ranges of Y 4 through Y 7 and Y 12 through Y 15 operate as gates and the molecule Y cannot make transition from a rotational level to another when a gate is found between them.

Selective molecular excitation method and isotope separation method using the same, isotope analysis method, selective molecular excitation apparatus and isotope separation apparatus

Molecules of a specific species can be selectively excited among molecules of a plurality of species that show only a slight difference of mass. Energy levels can be displayed on a graph where the horizontal axis indicates excitation energy. Assume an instance where an electromagnetic wave showing a comb-shaped spectrum having a plurality of narrow bands as indicated by P 1 through P 14 and tuning with excitation energies corresponding to the rotational levels of molecule X is irradiated onto the molecule X. The molecule X can sequentially make transitions to higher energy levels by using an electromagnetic wave showing such a comb-shaped spectrum. The energy levels of molecule Y are not synchronized with the comb-shaped spectrum. The two ranges of Y 4 through Y 7 and Y 12 through Y 15 operate as gates and the molecule Y cannot make transition from a rotational level to another when a gate is found between them.

方向指示具

【課題】 第１直円柱の側面の少なくとも一部に沿った凸形状の第１外面を有する対象物の第１外面に当接することで、第１直円柱の中心軸である第１軸を含む第１直線に対し垂直な直線である第１基準線の方向を第１外面から遠ざかる方向に示すことができる方向指示具を提供する。【解決手段】第１直円柱の側面の少なくとも一部に沿った凸形状の第１外面を有する対象物の第１外面の周方向に関して異なる少なくとも２の位置である第１当接位置に当接する第１当接部を有する当接部分と、第１当接部が第１当接位置に当接した際、第１直円柱の中心軸である第１軸を含む第１直線に対し垂直な直線である第１基準線に沿い、一端から他端に向かって第１直線から遠ざかる縁又は面である指示部を有する指示部分であって、該他端側が突出するように該一端側が当接部分に取り付けられる指示部分と、を備えてなる、方向指示具である。【選択図】図７

防護管の嵌合解除装置

(57)【要約】 【課題】 小型で、且つ、簡単な操作でポリ管の撤去作 業を行うことができる防護管の嵌合解除装置を得る。 【解決手段】 この嵌合解除装置は、ポリ管駆動機構３ ０と、開口保持装置４０とからなり、ポリ管駆動機構３ ０は、第一防護管Ｐ′の軸方向前方への移動が可能に構 成され、開口保持装置４０は、ポリ管駆動機構３０によ り第一防護管Ｐ′の軸方向の移動が可能となった状態の 第一防護管Ｐ′の雄嵌合部を第二防護管Ｐの雌嵌合部と 対向させて、第二防護管Ｐを保持するとともに、第二防 護管Ｐの雌嵌合部を弾性変形拡張させる。

聚酯化合物

本發明係提供一種耐熱性高的聚酯化合物，一種聚酯化合物，其係藉由使下述式(1)所示之化合物與下述式(2)所示之化合物反應而得到，式(1)所示之化合物： □ (式(1)中，R1係表示羥基、鹵素原子、烷氧基、環烷氧基、芳氧基、式：-OM所示之基、或式：-O-Si(R2)3所示之基，在此，M為金屬原子，R2為烷基；XDc係表示可具有取代基的二價芳香族基；YDc係表示式：-O-所示之基、式：-N=N-所示之基、羰基、可具有取代基的乙烯撐基、或單鍵；nDc係表示0~2之整數；具有的2個R1可為相同或相 異；當XDc具有複數個時，該等可為相同或相異；當YDc具有複數個時，該等可為相同或相異)；式(2)所示之化合物： □ (式(2)中，R4係表示氫原子、醯基、或式：-Si(R5)3所示之基，在此，R5為烷基；X係表示可具有取代基的二價芳香族基；Y係表示可具有取代基的甲烯基、式：-S(=O)2-所示之基、或單鍵；Z係表示可具有取代基的二價芳香族基；n係表示0或1；具有的2個R4可為相同或相異)。

熱交換装置

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

聚酯或聚醯胺之製造方法

本發明係提供一種新穎的聚酯及聚醯胺之製造方法，其係包含下述步驟之聚酯或聚醯胺之製造方法：使多元羧酸化合物或其衍生物、多元醇化合物或其衍生物或多元胺化合物或其衍生物，與下述式(1)所示之化合物(Ah)同時反應之步驟： □[式(1)中，l為1或2；RAh-1表示羥基、鹵素原子、烷氧基、環烷基氧基、芳基氧基、式：-OM所示之基、或式：-O-Si(RAh-4)3所示之基，在此，M為金屬原子、RAh-4為烷基；RAh-2當l=1時，表示式：=C=O所示之基，當l=2時，表示氫原子、醯基、或式：-Si(RAh-5)3所示之基，在此，RAh-5為烷基； RAh-3表示氫原子、醯基、或式：-Si(RAh-6)3所示之基，在此，RAh-6為烷基。RAh-2複數個存在時，該等可相同或相異。]。

Process for producing microbial transglutaminase

Disclosed are a protein having a transglutaminase activity, which comprises a sequence ranging from serine residue at the second position to proline residue at the 331st position in an amino acid sequence represented by SEQ ID No. 1 wherein the N-terminal amino acid of the protein corresponds to serine residue at the second position of SEQ ID No. 1, a DNA encoding the protein, a transformant having the DNA, and a process for producing a protein having a transglutaminase activity, which comprises the steps of culturing the transformant in a medium. The protein can be produced in a large amount with the transformant using a host such as E. coli.