Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 10. Отображено 10.
04-10-2012 дата публикации

SYSTEMS AND METHODS FOR CREATING SHARP FEATURES WITHIN A MOLD

Номер: US20120251790A1
Автор: Cordero Rafael M., Davidson Marc, Harhen Robert P., Young Adam J.
Принадлежит: Nellcor Puritan Bennett LLC

The present disclosure describes systems and methods for creating sharp features within a mold. For example, three or more mold plates may be provided to create a single mold assembly. Each mold plate includes one or more mold cavities, each having one or more surfaces. The provided mold plates may be assembled to form the mold assembly having a combined mold cavity between adjacent mold cavities of the mold plates. Although none of the individual mold cavities of the mold plates include sharp features, when the mold assembly is assembled, a combined mold cavity will include sharp transitions (e.g., angles of less than 180 degrees, right angles, angles of less than 90 degrees, and so forth) between adjacent surfaces of the mold cavities. In certain embodiments, sets of mold plates may be re-aligned to create varying mold cavity geometries. In addition, in certain embodiments, a mold pin may be inserted into an inner volume of a mold plate to both create additional sharp transitions between adjacent surfaces. 1. A mold assembly , comprising:a first mold plate having a first mold cavity with a first surface;a second mold plate having a second mold cavity with a second surface, wherein the first and second mold cavities are disposed adjacent each other to form a combined mold cavity when the first and second mold plates are aligned with each other, wherein a sharp transition is formed between the first and second surfaces when the first and second mold plates are aligned with each other, and wherein the first and second mold plates are configured to remain aligned with each other during multiple cycles of a molding operation; anda third mold plate disposed adjacent to the first and second mold plates to close the combined mold cavity.2. The mold assembly of claim 1 , wherein the sharp transition comprises an angle of less than 180 degrees where the first and second surfaces abut.3. The mold assembly of claim 1 , wherein the sharp transition comprises an angle of less ...

Подробнее
Номер записи: 1
04-10-2012 дата публикации

METHOD AND SYSTEM FOR POSITIONING A SENSOR

Номер: US20120253163A1
Автор: Afanasewicz Elizabeth A., Cordero Rafael M., Harhen Robert P., Young Adam J.
Принадлежит: Nellcor Puritan Bennett LLC

Embodiments of the present disclosure relate to sensor designs or shapes configured to facilitate placement of sensor electrodes and, thus, proper positioning of the sensors on patients. According to certain embodiments, a sensor may include a substrate that includes multiple electrodes, where a first electrode is configured to be placed on a patient's temple and a second electrode is configured to be placed on a patient's forehead directly above a patient's eyebrow. The sensor may include a particular shape and a fixed distance between the first and second electrodes to facilitate proper angling and positioning of the first and second electrodes as well as the other electrodes (e.g., third and fourth electrodes). Other embodiments may include a method for positioning the sensor on the patient, including a monitor with help screens. 1. A sensor comprising:an elongated substrate having a first end portion and a second end portion and having a first electrode disposed on the first end portion and a second electrode disposed on the second end portion, the first electrode and the second electrode being separated from one another by a distance substantially equal to a distance from a patient's temple to a central portion of a patient's forehead, such that the first electrode is adapted to be placed on a patient's temple and the second electrode is adapted to be placed on the central portion of the patient's forehead, the substrate being sufficiently rigid to substantially fix the distance between the first electrode and the second electrode and being sufficiently flexible to facilitate bending of the substrate about a patient's head when the first electrode is placed on the patient's temple and the second electrode is placed on the central portion of the patient's forehead.2. The sensor claim 1 , as set forth in claim 1 , wherein the substrate comprises an adhesive layer to facilitate attachment of the first electrode to the patient's temple and the second electrode to ...

Подробнее
Номер записи: 2
24-01-2013 дата публикации

DEVICE WITH ENCAPSULATED GEL

Номер: US20130023748A1
Автор: Afanasewicz Elizabeth A., Cordero Rafael M., Harhen Robert P., Young Adam J.
Принадлежит: Nellcor Puritan Bennett LLC

Apparatus and techniques are provided for interfacing a device with a surface. The apparatus and techniques provide gel encapsulation and isolation mechanisms to extend the shelf-life of the preparation devices, allow for the use of more effective materials, and improve the quality of the contact between a device and an application surface. Particular embodiments of these apparatus and techniques suitable for use in medical contexts are also provided. 1. A device for preparing a subject , comprising:at least one capsule containing a gel;a contact portion comprising a plurality of tines, positioned above the gel capsule; andan actuation surface, positioned above the contact portion;wherein, when the capsule of the preparation device is in contact with a subject, applying a downward force to the actuation surface causes the contact portion to compress the capsule and release the gel contained therein.2. The device of claim 1 , wherein applying a downward force to the actuation surface causes the contact portion to burst the capsule claim 1 , thereby releasing the gel contained therein.3. The device of claim 1 , wherein applying a downward force to the actuation surface causes the contact portion to pierce the capsule claim 1 , thereby releasing the gel contained therein.4. The device of claim 3 , wherein the capsule is pierced by at least one of the plurality of tines.5. The device of claim 3 , wherein the capsule is pierced by a piercing member of the contact portion.6. The device of claim 1 , wherein the capsule is not in contact with any of the plurality of tines prior to compressing the capsule.7. The device of claim 6 , wherein compressing brings the capsule into contact with at least one of the plurality of tines.8. The device of claim 1 , wherein the capsule is in contact with at least one of the plurality of tines prior to compressing the capsule.9. The device of claim 1 , wherein the actuation surface is concave.10. The device of claim 1 , wherein the capsule ...

Подробнее
Номер записи: 3
24-01-2013 дата публикации

FORCE REGULATING DEVICE APPLICATORS

Номер: US20130023749A1
Автор: Afanasewicz Elizabeth A., Cordero Rafael M., Harhen Robert P., Powers Gerald, Young Adam J.
Принадлежит: Nellcor Puritan Bennett LLC

Disclosed herein are apparatus and techniques for applying a device to a subject. Such apparatus and techniques may provide feedback to an operator and/or regulate the force used to apply the device, yielding an improved result. Particularly useful embodiments include apparatus and techniques for applying a medical device, such as a skin surface electrode or microneedle array, to a patient's tissue. 1. An apparatus for applying a device to a subject , the apparatus comprising:a force regulator capable of interfacing with the device, the force regulator capable of first and second configurations, wherein an operator may actuate a transition of the force regulator from the first configuration to the second configuration and wherein the force regulator automatically transitions to the first configuration when in the second configuration;wherein the force regulator regulates the force with which a contact portion of the device is applied to the subject when the force regulator transitions from the second to the first configuration.2. The apparatus of claim 1 , wherein the contact portion is applied to the subject with a predetermined force regulated by the force regulator.3. The apparatus of claim 2 , wherein the predetermined force comprises a maximum amount of force.4. The apparatus of claim 2 , wherein the predetermined force comprises a minimum amount of force.5. The apparatus of claim 1 , further comprising a feedback mechanism to alert the operator when the force regulator transitions to another configuration from at least one of the first and second configurations.6. The apparatus of claim 5 , wherein the feedback mechanism provides tactile feedback to the operator.7. The apparatus of claim 5 , wherein the feedback mechanism provides auditory feedback to the operator.8. The apparatus of claim 5 , wherein the feedback mechanism provides visual feedback to the operator claim 5 , wherein the visual feedback comprises one or more of a color change and a shape change. ...

Подробнее
Номер записи: 4
05-03-2020 дата публикации

SYSTEMS FOR ALLERGEN DETECTION

Номер: US20200071647A1
Автор: Anthony Joshua Glenn, Fleming Paul, Gilboa-Geffen Adi, Gorham Brett, GRISWOLD Ryan, KINTZ Gregory J., Murphy Patrick, Richardson Bruce, Young Adam J.
Принадлежит:

The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. A detection system for detecting the presence or absence of an allergen in a food sample , comprising(a) a food corer for collecting the food sample suspected of containing said allergen;(b) a disposable test cup configured for processing the food sample and contacting detection agents with said allergen presented in the food sample, the test cup comprising a port for inserting the food corer; and(c) a detection device configured for operating the allergen detection testing and measuring signals from the binding interaction between the detection agents and said allergen and visualizing the detection result, the device having a mate plane for docketing the test cup,wherein the detection device comprises an optical system for measuring said signals that includes excitation and emission optics, scatter optics and/or absorption optics.6. (canceled)7. The detection system of claim 5 , wherein the food corer claim 5 , from the distal end to the proximal end claim 5 , comprises a plunger claim 5 , a skirt and a corer claim 5 , wherein the proximal end of the corer includes a cutting edge for cutting the test sample.8. (canceled)9. (canceled)11. The detection system of claim 10 , wherein the cup body (ii) comprises a plurality of chambers claim 10 , each of which is functionally connected and a fluid can flow from one chamber to another claim 10 , wherein the cup body comprises at least(1) a homogenization chamber, wherein the test sample is homogenized and ...

Подробнее
Номер записи: 5
14-03-2019 дата публикации

SYSTEMS AND METHODS FOR ALLERGEN DETECTION

Номер: US20190079063A1
Автор: Anthony Joshua Glenn, Brown Renuka Babu, Gilboa-Geffen Adi, JACOBS Adam, Kepler John H., Murphy Patrick, Stidham Sarah, Villareal Valerie, Young Adam J.
Принадлежит:

The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample. 1. An allergen detection system comprising:(a) at least one sampler for collecting a test sample suspected of containing one or more allergens of interest;(b) at least one detection vessel for receiving and processing the test sample, and contacting detection agents with said one or more allergens presented in the test sample; and(c) a detection device for detecting the allergen content in the test sample by measuring and visualizing a signal from the binding interaction between the detection agents and the one or more allergens presented in the test sample.2. The detection system of claim 1 , wherein the sampler is a food pickup corer comprising a distal portion provided with a top cap at the distal end claim 1 , a proximal portion provided with a sample collecting tube claim 1 , a grip for handling the corer which is connected to the sample collecting tube claim 1 , and a plunger inside the sample collecting tube which has a distal end connected to the top cap and a plunger tip at the proximal end claim 1 , wherein the proximal plunger tip can protrude out from the sample collecting tube for picking up the test sample.3. (canceled)4. The detection system of claim 2 , wherein the food pickup corer is further provided with a means for weighing the test sample being picked up.5. The ...

Подробнее
Номер записи: 6
19-11-2020 дата публикации

Electrodes for Nitric Oxide Generation

Номер: US20200360649A1
Автор: Apollonio Benjamin, Gillerman Ian J., HALL Gregory W., Miles Christopher, Mohsenian Sina, Ortiz Aubrey, Scholz Wolfgang, Young Adam J.
Принадлежит:

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows. 1. A nitric oxide (NO) generation system , comprising:at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas, the at least one pair of electrodes having a first end and second end with a length therebetween such that a plasma produced is carried by the flow of the reactant gas and glides along the length of the at least one pair of electrodes from the first end towards the second end; anda controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes using one or more parameters as an input to the controller, the one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.2. The nitric oxide (NO) generation system of claim 1 , wherein the at least one pair of electrodes is formed from a material selected from the group consisting of hafnium claim 1 , glassy carbon claim 1 , iridium claim 1 , rhodium claim 1 , platinum claim 1 , graphite claim 1 , ...

Подробнее
Номер записи: 7
21-09-2017 дата публикации

Systems and methods for allergen detection

Номер: CA3013386A1
Автор: Adam J. Young, Adam Jacobs, Adi GILBOA-GEFFEN, John H. Kepler, Joshua Glenn ANTHONY, Patrick Murphy, Renuka Babu Brown, Sarah STIDHAM, Valerie VILLAREAL
Принадлежит: Dots Technology Corp

The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are also provided as allergen detection agents. SPNs have a single open structure, and are probed with a fluorophore. Changes in fluorescence polarization of detection agents upon the binding of allergens are measured to calculate the allergen content in a sample.

Подробнее
Номер записи: 8
02-02-2021 дата публикации

Systems and methods for allergen detection

Номер: US10908139B2
Автор: Adam J. Young, Adam Jacobs, Adi GILBOA-GEFFEN, John H. Kepler, Joshua Glenn ANTHONY, Patrick Murphy, Renuka Babu Brown, Sarah STIDHAM, Valerie VILLAREAL
Принадлежит: Dots Technology Corp

The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

Подробнее
Номер записи: 9
18-05-2023 дата публикации

Electrodes for Nitric Oxide Generation

Номер: US20230149656A1
Автор: Adam J. Young, Aubrey Ortiz, Benjamin Apollonio, Christopher Miles, Gregory W. HALL, Ian J. Gillerman, Sina Mohsenian, Wolfgang Scholz, Ziad F. Elghazzawi
Принадлежит: Third Pole Inc

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Подробнее
Номер записи: 10