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Применить Всего найдено 2. Отображено 2.
17-01-2024 дата публикации

Composition for administration of double-stranded oligonucleotide structures using ultrasonic nebulizer for prevention or treatment of respiratory viral infection including covid-19, pulmonary fibrosis caused by viral infection, or respiratory diseases

Номер: EP4306133A1
Автор: Eun-Ah GOH, Han-Oh Park, Jangseon KIM, Jun-Hong Park, Kang Song, Mi-Sun Lee, OH Seung Kwon, Sang-Kyu Lee, Soon-Ja Choi, Sung-Il YUN, Young-Ho GOH
Принадлежит: Bioneer Corp, Sirnagen Therapeutics Corp

The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. According to the method, the double-stranded oligonucleotide according to the present invention forms self-assembled nanoparticles, which are 90 nm in size and have a neutral charge, and it is possible to deliver the double-stranded oligonucleotide specifically to the nasal cavity and lungs while maintaining not only the same concentration, molecular weight, purity, nanoparticle size, and osmolality as those of the stock material but also the target gene inhibitory activity without cytotoxicity. Thus, the present invention may be useful for the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infection, or respiratory diseases.

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Номер записи: 1
15-09-2022 дата публикации

Composition for administration of double-stranded oligonucleotide structures using ultrasonic nebulizer for prevention or treatment of respiratory viral infection including covid-19, pulmonary fibrosis caused by viral infection, or respiratory disease

Номер: CA3210813A1
Автор: Eun-Ah GOH, Han-Oh Park, Jangseon KIM, Jun-Hong Park, Kang Song, Mi-Sun Lee, OH Seung Kwon, Sang-Kyu Lee, Soon-Ja Choi, Sung-Il YUN, Young-Ho GOH
Принадлежит: Bioneer Corp, Sirnagen Therapeutics Corp

The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. According to the method, the double-stranded oligonucleotide according to the present invention forms self-assembled nanoparticles, which are 90 nm in size and have a neutral charge, and it is possible to deliver the double-stranded oligonucleotide specifically to the nasal cavity and lungs while maintaining not only the same concentration, molecular weight, purity, nanoparticle size, and osmolality as those of the stock material but also the target gene inhibitory activity without cytotoxicity. Thus, the present invention may be useful for the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infection, or respiratory diseases.

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Номер записи: 2