14-05-2014 дата публикации
Номер: CN103784413A
Принадлежит:
The invention relates to the pharmaceutic preparation field and in particular relates to atenolol pH independent sustained-release tablets and a preparation method thereof. The atenolol pH independent sustained-release tablets are characterized by being prepared through the steps of evenly mixing a prescription amount of atenolol, HPMC (Hydroxy propyl methyl cellulose) K15M, eudragit RSPO, high-viscosity PEO (Polyethylene Oxide) and lactose monohydrate in such a manner of progressively increasing by equal amount, next, adding a small quantity of magnesium stearate and aerosil as the lubricant, and then forming the atenolol pH independent sustained-release tablets through a powder vertical-compression process. The pH independent sustained-release tablets are prepared effectively, and the slightly alkaline drug atenolol is provided to have similar release characteristic under different simulated gastrointestinal tract pH conditions. The HPMC stable in slow release performance is taken as ...
Подробнее