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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 4. Отображено 4.
23-05-2023 дата публикации

Olefin and halogenated hydrocarbon reaction method

Номер: CN116143584A
Автор: LI HONGXI, ZHAO YOUHUI, LI HAIYAN
Принадлежит:

The invention discloses a method for reacting olefin and halogenated hydrocarbon, a copper (I) coordination compound [Cu (dmp) (R1R2C3HN2PPh3)] BF4 is used as a catalyst to catalyze an atom transfer radical addition reaction between olefin and halogenated hydrocarbon molecules under visible light irradiation, and the method has the characteristics of high conversion efficiency, wide application range, mild reaction conditions and the like. The functional reaction of the aryl olefin recorded in the invention has the advantages of high conversion efficiency (the yield of the aryl olefin with a simple structure can reach 80%, even more than 90%, and the yield of the heterocyclic olefin can also reach about 80%), wide application range (not only suitable for addition of carbon tetrabromide, but also suitable for addition of other alkyl halides), and wide application range (not only suitable for addition of carbon tetrabromide, but also suitable for addition of other alkyl halides). Different ...

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Номер записи: 1
06-02-2008 дата публикации

Method for preparing steroids and novel intermediate compound used therein

Номер: CN0101117350A
Автор: JINLU LI, GUOFENG ZHAO, YOUHUI ZHAO, ZEBING ZENG, JING LI, BO CHEN, HAO YANG, LI JINLU, ZHAO GUOFENG, ZHAO YOUHUI, ZENG ZEBING, LI JING, CHEN BO, YANG HAO
Принадлежит:

The present invention relates to an improved preparation method of glucocorticoids steroid, in particular to the preparation methods of prednisolone acetate, cortisone, prednisolone or hydrocortisone. The present invention also relates to a new intermediate compound used in the process of preparing the compounds. The present invention provides a new synthetic route of iodo first and opening the ring after, improving the selectivity of final products, reducing the impurity content of the products, and satisfying the color scale of glucocorticoids drugs, thereby conquering the disadvantages of preparing 17 alpha- hydroxyl at first, and then preparing 21-hydroxyl or the derivatives during the process of preparing 17 alpha, 21-hydroxyl steroid or the derivatives of prior art.

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Номер записи: 2
01-04-2009 дата публикации

Preparation of metacortandralone and derivatives thereof

Номер: CN0101397324A
Автор: LI JINLU, LI ZHEN, ZHAO YOUHUI, JINLU LI, ZHEN LI, YOUHUI ZHAO
Принадлежит:

The invention relates to a preparation method of a steroid compound, in particular to the preparation for prednisolone and the derivative thereof, which takes 17-hydroxyl-1, 4, 9-triene- pregna-3, 20-diketone as the initiator and is improved by 9, 11th and 21st to obtain the prednisolone and the derivative thereof, such as prednisolone acetic ester, isoflupredone, and the like. The invention further provides the application of a compound (I) in the preparation of a compound (II). As the production process adopts the existing intermediate of the company as the initiator, the line is concise, the material is easy to obtain, expensive auxiliary materials are saved, and the yield and the cost are obviously superior to the historical synthetic method of the prednisolone and the derivative thereof; in addition, the adoption of the existing intermediate realizes the doubling production of the triamcinolone products and the prednisolone products, thus greatly reducing the production cost and industrial ...

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Номер записи: 3
27-06-2023 дата публикации

Copper (I) coordination compound as well as preparation method and application thereof

Номер: CN116332963A
Автор: LI HONGXI, ZHAO YOUHUI, LI HAIYAN
Принадлежит:

The invention discloses a copper (I) coordination compound as well as a preparation method and application thereof. Specifically, the chemical formula of the copper (I) coordination compound is [Cu (dmp) (R1R2C3HN2PPh3)] BF4, in which dmp is 2, 9-dimethyl-1, 10-phenanthroline, R1R2C3HN2PPh3 (R1 = R2 = H (1a), R1R2C3HN2PPh3 is 2, 9-dimethyl-1, 10-phenanthroline, and R1R2C3HN2PPh3 is 2, 9-dimethyl-1, 10-phenanthroline; r1 is H, and R2 is Me (1b); r1 is H, and R2 is Ph (1c); r1 = R2 = Me (1d)) is an iso-bidentate phosphine pyrazole ligand; the four mononuclear copper (I) complexes [Cu (dmp) (R1R2C3HN2PPh3)] BF4 (R1 = R2 = H (2a) are obtained by modifying R1 and R2 groups on a pyrazole phosphine ligand; r1 = H, R2 = Me (2b); r1 is H, and R2 is Ph (2c); r1 = R2 = Me (2d), and different modification groups can influence the structure, absorption, emission, redox potential and photocatalytic activity of the complex. The coordination compound can catalyze the atom transfer radical addition reaction ...

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Номер записи: 4