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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 518. Отображено 100.
30-03-2017 дата публикации

ELECTRONIC DEVICE INCLUDING AMBIENT LIGHT COMPENSATION CIRCUIT FOR HEART RATE GENERATION AND RELATED METHODS

Номер: US20170086689A1
Автор: Tao SHUI, Dong ZHENG, SHUI TAO, ZHENG DONG, SHUI Tao, ZHENG Dong
Принадлежит:

An electronic device may include an optical source capable of supplying light to an adjacent user's body part having blood flow therein and an optical sensor capable of sensing light from the user's body part. The electronic device may also include at least one gain stage coupled to the optical sensor and a compensation circuit coupled to the at least one gain stage and capable of generating a compensated output signal. The compensation circuit may include a memory capable of storing ambient light compensation data, and a digital-to-analog converter (DAC) coupled to the at least one gain stage and capable of compensating for ambient light based upon the stored ambient light compensation data. The electronic device may also include a processor capable of generating a user's heart rate based upon the compensated output signal. 1. An electronic device comprising:an optical source capable of supplying light to an adjacent user's body part having blood flow therein;an optical sensor capable of sensing light from the user's body part;at least one gain stage coupled to the optical sensor; a memory capable of storing ambient light compensation data, and', 'a digital-to-analog converter (DAC) coupled to the at least one gain stage and capable of compensating for ambient light based upon the stored ambient light compensation data; and, 'a compensation circuit coupled to the at least one gain stage and capable of generating a compensated output signal, the compensation circuit comprising'}a processor capable of generating a user's heart rate based upon the compensated output signal.2. The electronic device of wherein the compensation circuit further comprises a filter coupled to the memory and having at least one filter coefficient based upon a gain of the at least one gain stage.3. The electronic device of wherein the memory is capable of storing ambient light compensation data to account for ambient light interference errors.4. The electronic device of wherein the optical ...

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Номер записи: 1
12-01-2012 дата публикации

Cytotoxic Conjugates Having Neuropeptide Y Receptor Binding Compound

Номер: US20120010154A1
Автор: DEOLIVEIRA Daniel B., Dong Zheng Xin, Zhou Kevin
Принадлежит:

There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition states associated with aberrant or undesirable proliferation of cells that express NPY-Y1 receptors. 2. A compound according to claim 1 , wherein:said cytotoxic agent is selected from the group consisting of anthracycline, camptothecin, a camptothecin derivative, paclitaxel, a paclitaxel derivative, doxorubicin and a doxorubicin derivative;{'sup': '1', 'Bis rvAsp, rvD-Asp, rvCha, rvD-Cha, or rvGly;'}{'sup': '2', 'Bis Suc;'}{'sup': 3', '4, 'sub': m', 'n, 'each of Band Bis, independently for each occurrence, (Doc), (Aepa), or deleted;'}{'sup': 1', '2', '3, 'sub': 2', 'q, 'Ais Tyr or HN—CH((CH)—N(RR))—C(O);'}{'sup': '2', 'Ais Pro;'}{'sup': 3', '2', '3, 'sub': 2', 'q, 'Ais Ser, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 4', '2', '3, 'sub': 2', 'q, 'Ais Lys or HN—CH((CH)—N(RR))—C(O);'}{'sup': '5', 'Ais Pro;'}{'sup': 6', '2', '3, 'sub': 2', 'q, 'Ais Asp, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 7', '2', '3, 'sub': 2', 'q, 'Ais Asn, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': '8', 'Ais Pro;'}{'sup': 9', '2', '3, 'sub': 2', 'q, 'Ais Gly, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 10', '2', '3, 'sub': 2', 'q, 'Ais Glu, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 11', '2', '3, 'sub': 2', 'q, 'Ais Asp, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 12', '2', '3, 'sub': 2', 'q, 'Ais Ala, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': '13', 'Ais Pro;'}{'sup': 14', '2', '3, 'sub': 2', 'q, 'Ais Ala, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 15', '2', '3, 'sub': 2', 'q, 'Ais Glu, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 16', '2', '3, 'sub': 2', 'q, 'Ais Asp, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 17', '2', '3, 'sub': 2', 'q, 'Ais Met, A6c, Aib, Nle, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 18', '2', '3, 'sub': 2', 'q, 'Ais Ala, Aib, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 19', '2', '3, 'sub': 2', 'q, 'Ais Arg or HN—CH(( ...

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Номер записи: 2
16-02-2012 дата публикации

Analogues of Neuropeptide Y Having Proline Substitution At Position 34

Номер: US20120040886A1
Автор: Dong Zheng Xin
Принадлежит:

The present invention relates to novel analogues of neuropeptide Y, pharmaceutical compositions containing the same, pharmaceutical formulations containing the same, and method of treating diseases or conditions mediated by neuropeptide Y-receptor binding. More particularly, the present invention relates to novel analogues of neuropeptide Y having proline substitution at position 34 and other substitution(s) as defined herein that selectively bind to the neuropeptide Y1 receptor subtype compared to the neuropeptide Y2 receptor subtype. 2. A compound according to claim 1 , wherein:{'sup': 1', '4', '5, 'sub': 2', 'n, 'Ais Tyr or HN—CH((CH)—N(RR))—C(O);'}{'sup': '2', 'Ais Pro;'}{'sup': 3', '4', '5, 'sub': 2', 'n, 'Ais Ser or HN—CH((CH)—N(RR))—C(O);'}{'sup': 4', '4', '5, 'sub': 2', 'n, 'Ais Lys or HN—CH((CH)—N(RR))—C(O);'}{'sup': '5', 'Ais Pro;'}{'sup': 6', '4', '5, 'sub': 2', 'n, 'Ais Asp or HN—CH((CH)—N(RR))—C(O);'}{'sup': 7', '4', '5, 'sub': 2', 'n, 'Ais Asn or HN—CH((CH)—N(RR))—C(O);'}{'sup': '8', 'Ais Pro;'}{'sup': 9', '4', '5, 'sub': 2', 'n, 'Ais Gly or HN—CH((CH)—N(RR))—C(O);'}{'sup': 10', '4', '5, 'sub': 2', 'n, 'Ais Glu or HN—CH((CH)—N(RR))—C(O);'}{'sup': 11', '4', '5, 'sub': 2', 'n, 'Ais Asp or HN—CH((CH)—N(RR))—C(O);'}{'sup': 12', '4', '5, 'sub': 2', 'n, 'Ais Ala or HN—CH((CH)—N(RR))—C(O);'}{'sup': '13', 'Ais Pro;'}{'sup': 14', '4', '5, 'sub': 2', 'n, 'Ais Ala or HN—CH((CH)—N(RR))—C(O);'}{'sup': 15', '4', '5, 'sub': 2', 'n, 'Ais Glu or HN—CH((CH)—N(RR))—C(O);'}{'sup': 16', '4', '5, 'sub': 2', 'n, 'Ais Asp or HN—CH((CH)—N(RR))—C(O);'}{'sup': 17', '4', '5, 'sub': 2', 'n, 'Ais Met or HN—CH((CH)—N(RR))—C(O);'}{'sup': 18', '4', '5, 'sub': 2', 'n, 'Ais Ala or HN—CH((CH)—N(RR))—C(O);'}{'sup': 19', '4', '5, 'sub': 2', 'n, 'Ais Arg or HN—CH((CH)—N(RR))—C(O);'}{'sup': 20', '4', '5, 'sub': 2', 'n, 'Ais Tyr or HN—CH((CH)—N(RR))—C(O);'}{'sup': 21', '4', '5, 'sub': 2', 'n, 'ATyr or HN—CH((CH)—N(RR))—C(O);'}{'sup': 22', '4', '5, 'sub': 2', 'n, 'Ais Ser or HN—CH((CH)—N(RR))— ...

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Номер записи: 3
19-04-2012 дата публикации

CONFIGURABLE PHOTO DETECTOR CIRCUIT

Номер: US20120091320A1
Автор: Chamberlain Daryl, ZHENG Dong
Принадлежит: INTERSIL AMERICAS INC.

A configurable photo detector circuit comprises a photo detector array including a plurality of photo detectors coupled to a plurality of amplifiers. A method for programming a detection pattern of the configurable photo detector circuit comprises selecting a first detection pattern for the photo detector array, generating first signals to create the first selected detection pattern, and applying the first generated signals to the photo detector circuit to implement the first selected detection pattern. 1. A method of using a configurable photo detector circuit , comprising:receiving a first input to select a first switch configuration from a plurality of different switch configurations provided by a switching matrix;configuring the switches of the switching matrix to implement the selected first switch configuration from the plurality of different switch configurations provided by the switching matrix;receiving light at a plurality of photo detectors;converting light into a first set of electrical signals at the plurality of photo detectors; andselectively directing the first set of electrical signals to any of a first plurality of amplifiers based on the selected switch configuration.2. The method of claim 1 , wherein receiving the input comprises transferring data to a data transfer controller using an IC interface.3. The method of claim 1 , further comprising:directing a first photo detector output to a first amplifier input; anddirecting a second photo detector output to the first amplifier input.4. The method of claim 1 , further comprising:adjusting at least one of the gain, bandwidth, and offset of the plurality of amplifiers.5. The method of claim 1 , wherein the first switch configuration is configured for a first wavelength of light.6. The method of claim 1 , further comprising:receiving an input to select a second switch configuration from the plurality of different switch configurations provided by the switching matrix;configuring the switches of the ...

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Номер записи: 4
24-05-2012 дата публикации

USE OF A GHRELIN AGONIST TO IMPROVE THE CATABOLIC EFFECTS OF GLUCOCORTICOID TREATMENT

Номер: US20120129767A1
Автор: Culler Michael DeWitt, Dong Zheng Xin, Giustina Andrea, Tulipano Giovanni
Принадлежит:

A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin analogue, for example, [Aib, Glu(NH-hexyl)]hGhrelin(1-28)-NH(SEQ ID NO:2) or other suitable ghrelin agonist, to counteract the catabolic effects of said dexamethasone and other natural glucocorticoids. 1. A method to ameliorate the catabolic effects of excess glucocorticoids in an adult individual in need of such treatment comprising administering to said individual a therapeutically effective amount of a non-native ghrelin agonist.2. A method according to claim 1 , in which said non-native ghrelin agonist is [Aib claim 1 , Glu(NH-hexyl)]hGhrelin(1-28)-NH(SEQ ID NO:2).4. A method according to wherein said excess glucocorticoids are the result of a disease or a condition.5. A method according to wherein said excess glucocorticoids are the result of the long term administration of glucocorticoids to said individual.6. A method according to claim 5 , wherein said administered glucocorticoid is dexamethasone.7. A method according to claim 1 , wherein said glucocorticoid induced catabolic effects are selected from the group consisting of reduction in growth claim 1 , reduction in growth rate claim 1 , reduction in body weight claim 1 , reduction in lean body mass claim 1 , reduction in IGF-1 levels and reduction in bone mass.8. A method according to claim 7 , wherein said amelioration alleviates the reduction in growth in an individual with excess glucocorticoids.9. A method according to claim 7 , wherein said amelioration alleviates the reduction in growth rate in an individual with excess glucocorticoids.10. A method according to claim 7 , wherein said amelioration alleviates the reduction in body weight in said individual with excess glucocorticoids.11. A method according to claim 7 , wherein said reduction in body weight is due in part to a loss in lean body mass.12. A method ...

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Номер записи: 5
26-07-2012 дата публикации

Analogues of Insulin-Like Growth Factor-1 (IGF-1) Having Amino Acid Substitution at Position 59

Номер: US20120190616A1
Автор: Deborah M. Rothman, Jeanne Mary Comstock, Jundong Zhang, Maria L. Ufret, Nicholas C. Prairie, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn 59 )hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.

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Номер записи: 6
06-09-2012 дата публикации

Pharmaceutical Compositions of Melanocortin Receptor Ligands

Номер: US20120225816A1
Автор: Dong Zheng Xin, Zhang Jundong
Принадлежит: IPSEN Pharma, S.A.S.

The present invention relates to improvements in compositions containing peptides that are ligands of one or more of the melanocortin receptors (MC-R), or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NHwhich is a ligand of the melanocortin receptor subtype 4 (MC4-R), and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms a depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol (PEG) with an average molecular weight of lower than 1000. 132-. (canceled)33. A pharmaceutical composition for subcutaneous or intramuscular injection comprising a melanocortin receptor peptide ligand wherein said composition forms an in-situ depot after administration , wherein said depot is slowly dissolved and wherein said peptide is released into the body fluid and bloodstream.34. The pharmaceutical composition according to claim 33 , wherein said composition is a solution claim 33 , a gel claim 33 , a semi-solid or a suspension.35. The pharmaceutical composition according to claim 33 , wherein said composition is a purely aqueous solution claim 33 , a purely organic solution claim 33 , an aqueous solution having an organic component claim 33 , an aqueous solution having an inorganic component claim 33 , or an aqueous solution having both organic and inorganic components.36. The pharmaceutical composition according to claim 33 , wherein said peptide is:{'sub': '2', 'Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'hydantoin(Arg-Gly)-cyclo(Cys-Glu-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-D-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg- ...

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Номер записи: 7
06-09-2012 дата публикации

Process for the Synthesis of Ac-Arg-Cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2

Номер: US20120226018A1
Автор: Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention relates to a novel process for the synthesis of the melanocortin analog, Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH 2 , using solution-phase peptide chemistry.

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Номер записи: 8
01-11-2012 дата публикации

GLP-1 PHARMACEUTICAL COMPOSITIONS

Номер: US20120277151A1
Автор: ALLOZA MIRAVETE Resurreccion, Cherif-Cheikh Roland, CORDERO RIGOL Jose-Antonio, Dong Zheng Xin, LACOMBE Frederic, TOBALINA MAESTRE Maria Dolores
Принадлежит: IPSEN PHARMA S.A.S.

The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues. 163-. (canceled)65. The pharmaceutical composition according to claim 64 , wherein said zinc is present in a concentration from 0.0005 mg/mL to 50 mg/mL.66. The pharmaceutical composition according to claim 65 , wherein said zinc is present in a concentration from 0.01 mg/mL to 0.50 mg/mL.67. The pharmaceutical composition according to claim 64 , wherein said diluent comprises sterile water.68. The pharmaceutical composition according to claim 64 , wherein said pharmaceutical composition comprises an aqueous mixture claim 64 , suspension or solution claim 64 , and wherein said analog of glucagon-like peptide-1 is present at a concentration of approximately 0.5%-30% (w/w).69. The pharmaceutical composition according to claim 68 , wherein the concentration of said analog of glucagon-like peptide-1 in said aqueous mixture claim 68 , suspension or solution is approximately 1% claim 68 , 2% claim 68 , 3% claim 68 , 4% claim 68 , 5% claim 68 , 6% claim 68 , 7% claim 68 , 8% claim 68 , 9% claim 68 , 10% claim 68 , 11% claim 68 , 12% claim 68 , 13% claim 68 , 14% claim 68 , 15% claim 68 , 16% claim 68 , 17% claim 68 , 18% claim 68 , 19% claim 68 , 20% claim 68 , 21% claim 68 , 22% claim 68 , 23% claim 68 , 24% claim 68 , 25% claim 68 , 26% claim 68 , 27% claim 68 , 28% claim 68 , 29% claim 68 , or 30% (w/w).70. The pharmaceutical composition according to claim 69 , wherein the concentration of said analog of glucagon-like peptide-1 in said aqueous solution is approximately 1% claim 69 , 2% claim 69 , 3% claim 69 , 4% claim 69 , 5% claim 69 , 6% claim 69 , 7% claim 69 , 8% claim 69 , 9% claim 69 , 10% claim 69 , 11% claim 69 , 14% claim 69 , 15% claim 69 , 16% claim 69 , 19% claim 69 , 20% claim 69 , 21% claim 69 , 22% ...

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Номер записи: 9
22-11-2012 дата публикации

IMAGE AND VIDEO ENCODING AND DECODING

Номер: US20120294365A1
Автор: Wang Demin, Zhang Liang, ZHENG Dong
Принадлежит:

A method and system for image and video encoding and decoding is disclosed. A plurality of macro-blocks of pixels are defined in the image to be encoded, for subsequent block-by-block encoding and decoding. A node-cell structure of pixels is individually defined for each macro-block. The node pixels are encoded first. Then, the cell pixels are encoded using the decoded node pixels as a reference. This allows increasing macro-block size without a significant degradation of pixel encoding quality. 1. A method for encoding an image , implemented at least in part by a computing device , the method comprising:(a) defining in the image a plurality of macro-blocks of pixels, for subsequent block-by-block encoding; and (i) defining a portion of pixels of the first macro-block as node pixels, and defining the remaining pixels of the first macro-block as cell pixels, wherein the node pixels are disposed in a pre-defined pattern of pixels;', '(ii) encoding values of the node pixels of the first macro-block as node pixel information;', '(iii) reconstructing the values of the node pixels from the node pixel information of step (b)(ii); and', '(iv) encoding values of the cell pixels of the first macro-block as cell pixel information, using the reconstructed values of step (b)(iii)., '(b) for at least a first macro-block of the plurality of macro-blocks of step (a),'}2. The method of claim 1 , wherein in step (b)(i) claim 1 , the node pixels are non-adjacent to each other.3. The method of claim 2 , wherein in step (b)(i) claim 2 , the node pixels are unevenly spaced from each other.4. The method of claim 1 , wherein step (b) is repeated for a second macro-block of the plurality of macro-blocks of step (a) claim 1 , wherein node pixel patterns of the first and second macro-blocks differ from each other.5. The method of claim 1 , wherein in step (b)(i) claim 1 , the node pixels comprise a 2M×2N rectangular array of pixels claim 1 , wherein M and N are integers≧2 claim 1 , wherein ...

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Номер записи: 10
31-01-2013 дата публикации

PROCESS FOR THE SYNTHESIS OF (AIB8,35)HGLP-1(7-36)-NH2

Номер: US20130030148A1
Автор: Dong Zheng Xin, Hurley Fionn, JOHNSON STEVEN R., Loughman Thomas Ciaran
Принадлежит:

The present invention relates to a process for the large-scale synthesis of (Aib)hGLP-1(7-36)-NH2 (SEQ ED NO:2), i.e., His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gb-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 (SEQ ID NO:2), which comprises solid-phase Fmoc-chemistry. 1. A process for the synthesis of (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2) , which comprises stepwise solid-phase Fmoc-chemistry.2. A process for the synthesis of (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2) according to claim 1 , comprising the steps of:{'sup': '8,35', 'sub': '2', '(a) successively coupling Fmoc-amino acids, from the C-terminus to the N-terminus of (Aib)hGLP-1(8-35)-NH(SEQ ID NO:8), with a sidechain-protected Arg resin, wherein the Fmoc group is removed from the N-terminus after each successive coupling step, to yield a sidechain-protected Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg resin (SEQ ID NO:4);'}(b) coupling sidechain-protected Boc-His-OH with the sidechain-protected Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg resin (SEQ ID NO:4) to yield a sidechain-protected Boc-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg resin (SEQ ID NO:5);{'sup': '8,35', 'sub': '2', '(c) treating the sidechain-protected Boc-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg resin (SEQ ID NO:5) with a cleavage cocktail and removing the sidechain-protecting groups and the N-terminus protecting group therefrom to yield crude (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2); and'}{'sup': 8,35', '8,35, 'sub': 2', '2, '(d) isolating and purifying the crude (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2) to yield purified (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2).'}3. A process for the synthesis of (Aib)hGLP-1(7-36)-NH(SEQ ID NO:2) according to claim ...

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Номер записи: 11
28-03-2013 дата публикации

Distributed Light Sensors for Ambient Light Detection

Номер: US20130076712A1
Автор: Land Brian R., ZHENG Dong
Принадлежит:

An electronic device may have a display with a brightness that is adjusted based on ambient light data from multiple ambient light sensors. Sensors that are shadowed can be ignored. A touch sensor array in the display may have electrodes that overlap ambient light sensors. When a touch sensor signal indicates that an external object is covering one of the ambient light sensors, data from that ambient light sensor can be discarded. The ambient light sensors may include a primary ambient light sensor such as a human-eye-response ambient light sensor and may include an array of secondary ambient light sensors such as non-human-eye-response sensors. The secondary ambient light sensors may be formed on a display layer such as a thin-film-transistor layer and may be formed from thin-film materials. An algorithm may be used to dynamically calibrate non-human-eye-response ambient light sensors to the human-eye-response ambient light sensor. 1. An electronic device , comprising:a human-eye-response ambient light sensor; andat least one non-human-eye-response ambient light sensor.2. The electronic device defined in further comprising:storage and processing circuitry configured to process ambient light sensor data from the human-eye-response ambient light sensor and the at least one non-human-eye-response ambient light sensor.3. The electronic device defined in further comprising a display having an adjustable display brightness claim 2 , wherein the storage and processing circuitry is configured to adjust the display brightness in response to the ambient light sensor data.4. The electronic device defined in wherein the display comprises a plurality of layers and wherein the non-human-eye-response ambient light sensor is formed on a given one of the plurality of layers.5. The electronic device defined in wherein the given one of the plurality of layers comprises a thin-film-transistor layer.6. The electronic device defined in further comprising a display claim 1 , wherein the ...

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Номер записи: 12
02-05-2013 дата публикации

PROJECTOR SYSTEMS WITH LIGHT BEAM ALIGNMENT

Номер: US20130107133A1
Автор: Chamberlin Daryl, ZHENG Dong
Принадлежит: INTERSIL AMERICAS INC.

Embodiments of the present invention generally relate to circuits, systems and methods that can be used to detect light beam misalignment, so that compensation for such misalignment can be performed. In accordance with an embodiment, a circuit includes a photo-detector (PD) having a plurality of electrically isolated PD segments. Additionally, the circuit has circuitry, including switches, configured to control how currents indicative of light detected by the plurality of electrically isolated PD segments are arithmetically combined. When the switches are in a first configuration, a signal produced by the circuitry is indicative of vertical light beam alignment. When the switches are in a second configuration, the signal produced by the circuitry is indicative of horizontal light beam alignment. The signals indicative of vertical light beam alignment and horizontal light beam alignment can be used detect light beam misalignment, so that compensation for such misalignment can be performed. 1. A projector system , comprising:a first light emitting element that emits light of a first color;a second light emitting element that emits light of a second color;a third light emitting element that emits light of a third color;a controller configured to produce first, second and third pixel data in dependence on a video signal received from a video source;a driver configured to drive the first, second and third light emitting elements in dependence on the first, second and third pixel data produced by the controller;one or more micro-mirror(s) that project an image in dependence on light beams produced in dependence on the light of the first, second and third colors emitted by the first, second and third light emitting elements; and a plurality of electrically isolated photodetector (PD) segments; and', 'circuitry configured to control how currents indicative of light detected by the plurality of electrically isolated PD segments are arithmetically combined;, 'an opto- ...

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Номер записи: 13
16-05-2013 дата публикации

Growth Hormone Releasing Peptides

Номер: US20130123170A1
Автор: Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: R 1 -A 1 -A 2 -A 3 -A 4 -A 5 -R 2   (I) wherein: A 1 is Aib, Apc or Inp; A 2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A 3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A 4 is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A 5 is Apc, Dab, Dap, Lys, Orn, or deleted; R 1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R 2 is OH or NH 2 ; and pharmaceutical compositions and methods of use thereof.

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Номер записи: 14
15-08-2013 дата публикации

Pharmaceutical Compositions of Growth Hormone Secretagogue Receptor Ligands

Номер: US20130210751A1
Автор: Jundong Zhang, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention relates to improvements in compositions containing peptides that are ligands of the GHS receptor, or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and methods of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of H-Inp-D-Bal-D-Trp-Phe-Apc-NH2, which is a ligand of the GHS receptor and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms an in situ depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol with an average molecular weight of lower than 1000.

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Номер записи: 15
22-08-2013 дата публикации

CONFIGURABLE PHOTO DETECTOR CIRCUIT

Номер: US20130214133A1
Автор: Chamberlain Daryl, ZHENG Dong
Принадлежит: INTERSIL AMERICAS INC.

A configurable photo detector circuit comprises a photo detector array including a plurality of photo detectors coupled to a plurality of amplifiers. A method for programming a detection pattern of the configurable photo detector circuit comprises selecting a first detection pattern for the photo detector array, generating first signals to create the first selected detection pattern, and applying the first generated signals to the photo detector circuit to implement the first selected detection pattern.

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Номер записи: 16
31-10-2013 дата публикации

TOTAL-SKY LIGHTNING EVENT OBSERVATION SYSTEM AND METHOD

Номер: US20130286203A1
Автор: Lv Weitao, Ma Ying, Meng Qing, YANG Jun, Yao Wen, Zhang Yang, Zhang Yijun, ZHENG Dong
Принадлежит: Chinese Academy of Meteorological Sciences

A total-sky lightning event observation system and method may include a photographing device, a housing, a temperature control device, a light shielding device, a control module, a power supply module, a corona current sensor, a data acquisition device, a GPS antenna, a GPS timing module and a processing unit. The photographing device can capture total-sky digital images and transmit the images directly to the processing unit. The processing unit consecutively acquire corona current via the data acquisition device and judges whether there exists thunderstorm activity within the observed range; if there exists thunderstorm activity, the light shielding device is opened so as to enter a lightning observation mode, and the light shielding device is closed after the observation is finished so as to protect the photographing device in non-thunderstorm weather. 1. A total-sky lightning event observation system , comprising:a housing, a top of which has an opening, at which a transparent protective cover is mounted;a photographing device disposed in the housing and at the opening;a sensor for sensing a representative parameter of the thunderstorm activity and producing sensed data;a data acquisition device for acquiring the sensed data from the sensor;a processing unit for receiving the sensed data from the data acquisition device, the processing unit setting the system in a first operational mode and the data acquisition device in a first data acquiring mode when the sensed data indicates there is no thunderstorm activity within a range observed by the system, and the processing unit setting the system in a second operational mode and the data acquisition device in a second data acquiring mode when the sensed data indicates there exists thunderstorm activity within the range observed by the system; anda control module disposed within the housing, the control module receiving a first instruction from the processing unit and shutting down the photographing device based on ...

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Номер записи: 17
05-12-2013 дата публикации

RAPIDLY DEPLOYABLE STRUCTURES BASED UPON NEGATIVE POISSON'S RATIO (NPR) AUXETIC COMPONENTS

Номер: US20130322955A1
Автор: Ma Zheng-Dong
Принадлежит:

Reconfigurable, expandable-collapsible structures based upon negative Poisson's ratio (NPR) auxetic unit cells achieve rapidly deployable apparatus, devices and systems. A plurality of joint bodies, each joint body having a plurality of connection features, are coupled to interconnecting link members with opposing ends, each end including connection features that engage with the connection features of the joint bodies. The link members pivot about different axes relative to the joint bodies, thereby forming an expandable and collapsible structure having a height and a width. The link members form an array of geometric unit cells when the structure is expanded, and the height and the width of the structure when expanded are both greater than the height and the width of the structure when collapsed. In certain embodiments the structures have unit cells based upon triangles or bowtie shapes. 1. An expandable-collapsible structure , comprising:a plurality of joint bodies, each joint body having a plurality of connection features;a plurality of interconnecting link members with opposing ends, each end including connection features that engage with the connection features of the joint bodies such that the link members pivot about different axes relative to the joint bodies, thereby forming an expandable and collapsible structure having a height and a width; andwherein the link members form an array of geometric unit cells when the structure is expanded; andthe height and the width of the structure when expanded are both greater than the height and the width of the structure when collapsed.2. The structure of claim 1 , wherein some of the interconnecting link members form parallel claim 1 , straight lines when the structure is expanded.3. The structure of claim 1 , wherein the unit cells are triangles or bowtie shapes.4. The structure of claim 1 , wherein some of the interconnecting link members form parallel claim 1 , straight lines when the structure is expanded.5. The ...

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Номер записи: 18
09-01-2014 дата публикации

Melanocortin Receptor Ligands Modified with Hydantoin

Номер: US20140011730A1
Автор: COMSTOCK Jeanne Mary, DEOLIVEIRA Daniel B., Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction. 2. A compound according to claim 1 , wherein said compound is a selective melanocortin-4 receptor agonist.7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier or diluent.8. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 2 , and a pharmaceutically acceptable carrier or diluent.9. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 3 , and a pharmaceutically acceptable carrier or diluent.10. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 4 , and a pharmaceutically acceptable carrier or diluent.11. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 5 , and a pharmaceutically acceptable carrier or diluent.12. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof claim 6 , and a pharmaceutically acceptable carrier or diluent.13. A method of treating a disease or medical condition in a subject in need of such treatment claim 2 , comprising administering to said subject a compound according to claim 2 , wherein said disease or condition is selected from the group consisting of:general inflammation, inflammatory bowel disease, brain inflammation, ...

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Номер записи: 19
16-01-2014 дата публикации

BUSHINGS AND BUMPERS BASED UPON NPR (NEGATIVE POISSON'S RATIO) STRUCTURES

Номер: US20140017422A1
Автор: Ma Zheng-Dong
Принадлежит:

NPR (negative Poisson's ratio) components for vehicle and other applications generally assume a tubular structure defining an axis, a length and a cross section. The structure is composed of a plurality of nested, double-V unit cells, each unit cell comprising a pair of side points A and B defining a width, a first pair of tensile members interconnecting points A and B and intersecting at a point C forming a first V shape, a second pair of stuffer members interconnecting points A and B and intersecting at a point D forming a second V shape. The unit cells are connected in a first direction with the point B of one cell being connected to point A of an adjoining cell, and so on, until completing a continuous band. The unit cells are further connected in a second direction with the point D of one cell being connected to point C of an adjoining cell. In one embodiment, the bands are stacked radially outwardly from the axis to form a bushing. In accordance with a second embodiment, the bands are stacked lengthwise along the structure to form a joust bumper. 1. A NPR (negative Poisson's ratio) component , comprising:a tubular structure defining an axis, a length and a cross section;the structure being composed of a plurality of nested, double-V unit cells, each unit cell comprising a pair of side points A and B defining a width, a first pair of tensile members interconnecting points A and B and intersecting at a point C forming a first V shape, a second pair of stuffer members interconnecting points A and B and intersecting at a point D forming a second V shape;the unit cells being connected in a first direction with the point B of one cell being connected to point A of an adjoining cell, and so on, until completing a continuous band;the unit cells being further connected in a second direction with the point D of one cell being connected to point C of an adjoining cell; and wherein:the bands are stacked radially outwardly from the axis to form a bushing; orthe bands are ...

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Номер записи: 20
13-03-2014 дата публикации

Optical Proximity Sensor With Ambient Light and Temperature Compensation

Номер: US20140070078A1
Автор: Land Brian R., ZHENG Dong
Принадлежит:

An electronic device may be provided with a proximity sensor. The proximity sensor may include a light source such as a light-emitting diode and a light detector such as a photodiode. The light-emitting diode may be driven with an alternating current drive signal so that alternating current light is produced. The alternating current light may reflect off of an external object and may be received by the photodiode. The photodiode may receive a direct current light signal associated with the presence of ambient light. The efficiency of the photodiode may be affected by the level of ambient light and the efficiency of the light-emitting diode may be affected by the temperature of the light-emitting diode. Ambient light correction circuitry and temperature correction circuitry may be used to ensure that proximity sensor readings are not adversely affected by changes in operating temperature and ambient lighting conditions. 1. A light-based proximity sensor , comprising:a light source that emits light towards an external object;a photodetector that is configured to measure light from the light source that has reflected off of the external object; andan ambient light correction circuit that corrects signals from the photodetector for photodetector efficiency changes due to changes in how much ambient light is received by the photodetector.2. The light-based proximity sensor defined in further comprising a temperature correction circuit that corrects signals from the photodetector for light-emitting-diode efficiency changes due to changes in temperature.3. The light-based proximity sensor defined in wherein the light source comprises a light-emitting diode that emits an alternating current infrared light signal.4. The light-based proximity sensor defined in further comprising a low pass filter interposed between the photodetector and the ambient light correction circuit.5. The light-based proximity sensor defined in further comprising an efficiency correction factor ...

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Номер записи: 21
07-01-2021 дата публикации

DUDOU-SHAPED TEST BLOCK

Номер: US20210003537A1
Автор: Chen Changhua, Chen Qingyong, DONG Zheng, HA Yao, Liu Xiaolei, XU Zhengmao, ZHANG Hong, Zhang Li
Принадлежит: NANJING DEVELOP ADVANCED MANUFACTURING CO., LTD.

A dudou-shaped test block includes a testing structure, a first beam-path structure, and a second beam-path structure. A first arc-shaped groove and a second arc-shaped groove are provided on one side of the testing structure. The other side of the testing structure is a flat surface. The first beam-path structure and the second beam-path structure are both flat plates. A thickness of the first beam-path structure is less than a thickness of the second beam-path structure. The first beam-path structure and the second beam-path structure are both in contact with the flat surface and arranged parallel to the flat surface. The first arc-shaped groove is arranged corresponding to the first beam-path structure, and the second arc-shaped groove is arranged corresponding to the second beam-path structure. 1. A dudou-shaped test block , comprising a testing structure , a first beam-path structure , and a second beam-path structure , wherein a first arc-shaped groove and a second arc-shaped groove are provided on a first side of the testing structure , a second side of the testing structure is a first flat surface , the first beam-path structure and the second beam-path structure are a first flat plate and a second flat plate , a thickness of the first beam-path structure is less than a thickness of the second beam-path structure , the first beam-path structure and the second beam-path structure are both in contact with the flat surface and arranged parallel to the flat surface , the first arc-shaped groove is arranged corresponding to the first beam-path structure , and the second arc-shaped groove is arranged corresponding to the second beam-path structure.2. The dudou-shaped test block according to claim 1 , wherein the first arc-shaped groove and the second arc-shaped groove are both ¼ arc-shaped grooves.3. The dudou-shaped test block according to claim 2 , wherein a first side where the first arc-shaped groove is closest to the second arc-shaped groove is away from the ...

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Номер записи: 22
07-01-2021 дата публикации

Electronic Devices With Ambient Light Sensors and Emissive Displays

Номер: US20210004053A1
Автор: Aflatooni Koorosh, Dodson Christopher M., Shao Guocheng, Vampola Kenneth J., ZHENG Dong
Принадлежит:

An electronic device may have a display with an array of pixels that display images for a user. The electronic device may have an ambient light sensor for gathering ambient light information. A subset of the pixels in the array of pixels may overlap the ambient light sensor so that ambient light passing through the subset of pixels may be measured. Each pixel may have an emission enable transistor coupled in series with a light-emitting diode. Control circuitry in the electronic device may disable the subset of pixels to reduce stray light during ambient light measurements while enabling remaining pixels in the array of pixels to display an image. Ambient light sensor circuitry may gather ambient light sensor measurements over one or more periods by using transfer transistors to transfer change from the photodetectors to charge storage capacitors formed from floating diffusions in a common substrate. 1. An electronic device comprising:a display having an array of pixels;light measurement circuitry having photodetectors formed in a semiconductor substrate, wherein the photodetectors are configured to gather light measurements on light passing through a subset of the array of pixels overlapping the photodetectors; andcontrol circuitry configured to take action in response to the light measurements gathered by the light measurement circuitry.2. The electronic device of claim 1 , wherein the control circuitry is configured to adjust a content output by the display based on the light measurements gathered by the light measurement circuitry.3. The electronic device of claim 1 , wherein the light measurement circuitry comprises:floating diffusion regions formed in the semiconductor substrate.4. The electronic device of claim 3 , wherein the light measurement circuitry comprises:transistors that are each respectively formed in the semiconductor substrate between one of the photodetectors and one of the floating diffusion regions.5. The electronic device of claim 1 , further ...

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Номер записи: 23
19-01-2017 дата публикации

ULTRALIGHTWEIGHT AIRLESS ATV WHEELS BASED UPON NEGATIVE POISSON RATIO (NPR) AUXETIC STRUCTURES

Номер: US20170015134A1
Автор: Ma Zheng-Dong
Принадлежит:

Improvements are disclosed regarding the way in which vehicle wheels are designed and assembled, including ultralight, airless vehicle wheels adapted for mounting on a rim to receive a tire. One or more flexible ring-shaped tendons are disposed over the rim. A stuffer component is disposed over the tendons, and the wheel is disposed over the stuffer. A cover is bolted onto the rim holding the stuffer and tendons in position. Importantly, the tendons, stuffer and cover are all installed onto the rim from the outside toward the vehicle, thereby easing installation and maintenance. The invention may be adapted for all-terrain vehicles, and the wheel may have diameter on the order of 7 inches, 14 inches, or any other appropriate dimensions. 1. An ultralight , airless vehicle wheel adapted for mounting on a rim to receive a tire , comprising:one or more flexible ring-shaped tendons disposed over the rim;a stuffer component disposed over the tendons;the wheel being disposed over the stuffer; anda cover bolted onto the rim holding the stuffer and tendons in position.2. The ultralight claim 1 , airless vehicle wheel of claim 1 , wherein tendons claim 1 , stuffer and cover are all installed onto the rim from the outside toward the vehicle.3. The ultralight claim 1 , airless vehicle wheel of claim 1 , wherein:the stuffer is constructed from a plurality of components having V-shaped cross sections;the rim includes a plurality of spokes with elongate axial spaced-apart surfaces; andthe tendon(s) are disposed between the V-shaped components of the stuffer and the spaced-apart surfaces to create a negative Poisson ratio (NPR) or auxetic structure whereby the stiffness of the structure in the localized region of loading increases due to terrain contact as the wheel rotates.4. The ultralight claim 1 , airless vehicle wheel of claim 1 , wherein the stuffer is a fiber-reinforced composite claim 1 , magnesium claim 1 , or aluminum.5. The ultralight claim 1 , airless vehicle wheel of ...

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Номер записи: 24
16-01-2020 дата публикации

Growth Hormone Releasing Peptides

Номер: US20200017548A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: 2. A compound according to claim 1 , wherein:{'sup': '1', 'Ais Aib, Apc or H-Inp;'}{'sup': '2', 'Ais D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp;'}{'sup': '3', 'Ais D-Bal, D-Bpa, D-Dip, D-1Nal, D-2Nal, or D-Trp;'}{'sup': '4', 'Ais Orn, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, or Thr(Bzl); and'}{'sup': '5', 'Ais Apc, Lys, or deleted;'}or a pharmaceutically acceptable salt thereof.3. A compound according to claim 2 , wherein:{'sup': '1', 'Ais Apc or H-Inp;'}{'sup': '2', 'Ais D-Bal, D-Bip, D-1Nal, or D-2Nal;'}{'sup': '3', 'Ais D-Bal, D-1Nal, D-2Nal, or D-Trp;'}{'sup': '4', 'Ais 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, or Thr(Bzl); and'}or a pharmaceutically acceptable salt thereof.4. A compound according to claim 1 , wherein said compound is according to the formula:{'sub': '2', 'H-Inp-D-1Nal-D-Trp-3Pal-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-4Pal-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Orn-Lys-NH;'}{'sub': '2', 'H-Inp-D-Bip-D-Trp-Phe-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Thr(Bzl)-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Pff-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-2Thi-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Taz-Lys-NH;'}{'sub': '2', 'H-Inp-D-Dip-D-Trp-Phe-Lys-NH;'}{'sub': '2', 'H-Inp-D-Bpa-D-Trp-Phe-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Bpa-Phe-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-3Pal-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-4Pal-NH;'}{'sub': '2', 'H-Inp-D-1Nal-D-Trp-3Pal-NH;'}{'sub': '2', 'H-Inp-D-Bip-D-Trp-Phe-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Thr(Bzl)-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Pff-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-2Thi-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Taz-NH;'}{'sub': '2', 'H-Inp-D-Dip-D-Trp-Phe-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Dip-Phe-NH;'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-Phe-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Bal-Phe-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-3Pal-Lys-NH;'}H-Inp-D-Trp-D-2Nal(ψ)- ...

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Номер записи: 25
22-01-2015 дата публикации

Cell Selection and Reselection Optimizations Responsive to Mobility State

Номер: US20150024743A1
Автор: Diwan Aniruddha Subhash, Mhetre Vikram Shantveer, Ranjan Rishi, ZHENG Dong
Принадлежит: BROADCOM CORPORATION

User equipment (UE) obtains system information using a foreground or background process. The system information may include cell information that distinguishes femtocells from macrocells. Given this cell information, the UE may avoid tuning to or attempting to connect to cell types that the UE does not support. For instance, the UE may avoid connection attempts to femtocells, when the UE does not support femtocell connections. 1. A method comprising:receiving, in user equipment, system information comprising cell type distinguishing information;determining a cell type that the user equipment does not support; andin scanning for cells to connect to, skipping those cells that the user equipment does not support, based on the cell type distinguishing information.2. The method of claim 1 , where receiving comprises:receiving while tuned to the cell type that the user equipment does not support.3. The method of claim 1 , where receiving comprises:receiving while camped onto a cell type that the user equipment does support.4. The method of claim 1 , where receiving comprises:receiving in the foreground in response to a mobility state determination for the user equipment.5. The method of claim 4 , where receiving in the foreground comprises:obtaining system information while tuned to the cell type that the user equipment does not support, as the user equipment searches for a cell type that the user equipment does support.6. The method of claim 1 , where receiving comprises:receiving in the background in response to a mobility state determination for the user equipment.7. The method of claim 6 , where receiving in the background comprises:obtaining system information while camped to a cell type that the user equipment does support, by tuning while the user equipment is Idle to a cell type that the user equipment does not support.8. The method of claim 1 , where the cell type distinguishing information comprises specific physical cell identities.9. The method of claim 1 , ...

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Номер записи: 26
22-01-2015 дата публикации

Femtocell Fingerprinting

Номер: US20150024760A1
Автор: Abhishek Pandit, Aniruddha Subhash Diwan, DONG Zheng, Mojan Mohajer, Odile Rollinger, Sagar Nargundkar, Sandeep Sarthavalli Ramesh, Soma Majumdar, Sridhar Prakasam, Sudip Alexei Gupta, Sultan Budhwani, Vikram Shantveer Mhetre, YUAN LIU
Принадлежит: Broadcom Corp

User equipment (UE) includes an architecture for handling femtocell fingerprints. The architecture may, as examples, maintain the validity and reliability of fingerprints and coordinate enhancement to existing fingerprints. The architecture also supports fingerprint creation, updating, and deletion.

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Номер записи: 27
29-01-2015 дата публикации

Growth Hormone Releasing Peptides

Номер: US20150031615A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: 1. A compound selected from the group consisting of:{'sub': '2', 'H-Inp-D-Bal-D-Trp-Phe-Apc-NH;'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-Phe-Lys-NH;'}{'sub': '2', 'H-Inp-D-2Nal-D-Trp-Phe-Apc-NH;'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-Taz-Apc-NH;'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-2Thi-Apc-NH; and'}pharmaceutically acceptable salts thereof.2. A compound which is H-Inp-D-Bal-D-Trp-Phe-Apc-NH , or a pharmaceutically acceptable salt thereof.3. A compound which is H-Inp-D-Bal-D-Trp-Phe-Lys-NH , or a pharmaceutically acceptable salt thereof.4. A compound which is H-Inp-D-2Nal-D-Trp-Phe-Apc-NH , or a pharmaceutically acceptable salt thereof.5. A compound which is H-Inp-D-Bal-D-Trp-Taz-Apc-NH , or a pharmaceutically acceptable salt thereof.6. A compound which is H-Inp-D-Bal-D-Trp-2Thi-Apc-NH , or a pharmaceutically acceptable salt thereof.76. A pharmaceutical composition comprising the compound of any one of to claims 1 , and a pharmaceutically acceptable carrier. This application is a continuation application of U.S. Ser. No. 13/734,314, filed Jan. 4, 2013, which is a continuation application of U.S. Ser. No. 12/157,224, filed Jun. 9, 2008, now U.S. Pat. No. 8,377,865, which is a continuation application of U.S. Ser. No. 10/484,473, filed Feb. 4, 2005, now U.S. Pat. No. 7,456,253, which is a United States national filing under 35 U.S.C. §371 of international (PCT) application No. PCT/US2003/024834, filed Aug. 8, 2003, designating the United States, and claiming priority to U.S. provisional application No. 60/402,263, filed Aug. 9, 2002.The material in the text file, “120P_PCT2_US_C_SeqList_ST25.txt”, created Oct. 9, 2014, having the file size of 1 KB, is incorporated herein by reference.The pulsatile release of growth hormone from the pituitary somatotrops is regulated by two hypothalamic neuropeptides: growth hormone-releasing hormone and somatostatin. Growth hormone- ...

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Номер записи: 28
09-02-2017 дата публикации

Composition and Methods for Stimulating Gastrointestinal Motility

Номер: US20170037104A1
Автор: Datta Rakesh, Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient. 1. A method of stimulating the motility of the gastrointestinal system in a patient , said method comprising administering a peptidyl analog of ghrelin , a prodrug thereof , or a pharmaceutically acceptable salt of said analog or said prodrug.2. The method of claim 1 , wherein said patient is experiencing postoperative ileus following gastrointestinal surgery.3. The method of either or claim 1 , wherein said patient is either concurrently being administered or has previously been administered opioid analgesics.4. The method of wherein said peptidyl analog of ghrelin comprises the following formula (I):{'br': None, 'sup': 2', '3', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27', '28', '1, '(RR)-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-R\u2003\u2003(I)'} [{'sup': '1', 'Ais Gly, Aib, Ala, β-Ala, or Acc;'}, {'sup': '2', 'Ais Ser, Aib, Act, Ala, Acc, Abu, Ava, Thr, or Val;'}, {'sup': 3', '4', '8', '9', '14', '10', '11', '6', '7', '5', '12', '13, 'sub': 2', '2', '2', 'n, 'Ais Ser, Ser(C(O)—R), Asp(O—R), Asp(NH—R), Cys(S—R), Dap(S(O)—R), Dab(S(O)—R), Glu(O—R), Glu(NH—R), Thr, Thr(C(O)—R), or HN—CH((CH)—N(RR))—C(O);'}, {'sup': 4', '1', '2', '3', '4', '5, 'Ais Phe, Acc, Aic, Cha, 2-Fua, 1-Nal, 2-Nal, 2-Pal, 3-Pal, 4-Pal, hPhe, (X,X,X,X,X)Phe, Taz, 2-Thi, 3-Thi, Trp, or Tyr;'}, {'sup': '5', 'Ais Leu, Abu, Acc, Aib, Ala, Cha, Ile, hLeu, Nle, Nva, Phe, Tle, or Val;'}, {'sup': '6', 'Ais Ser, Abu, Acc, Act, Aib, Ala, Gly, Thr, or Val;'}, {'sup': '7', 'Ais Pro, Dhp, Dmt, 3-Hyp, 4-Hyp, Inc, Ktp, Oic, Pip, Thz, Tic, or deleted;'}, {'sup': 8', '12', '13, 'sub': ...

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Номер записи: 29
01-05-2014 дата публикации

Somatostatin-Dopamine Chimeric Analogs

Номер: US20140121354A1
Автор: Dong Zheng Xin, KIM Sun Hyuk, SHEN Yeelana
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions. 1. A compound , wherein said compound is:{'sub': '2', 'Dop1-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:4);'}{'sub': '2', 'Dop1-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:5);'}{'sub': '2', 'Dop1-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:6);'}{'sub': '2', 'Dop1-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr) (SEQ ID NO:12);'}{'sub': '2', 'Dop1-Lys(Dop1)-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr) (SEQ ID NO:13);'}{'sub': '2', 'Dop1-Lys(Dop1)-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:14);'}{'sub': 2', '2, 'Dop1(SO)-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:15);'}{'sub': '2', 'Dop1(SO)-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr) (SEQ ID NO:18);'}{'sub': '2', 'Dop1(SO)-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:19);'}{'sub': '2', 'Dop1(SO)-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:20);'}{'sub': '2', 'Dop1(SO)-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:21);'}{'sub': '2', 'Dop 1(SO)-Lys[Dop1(SO)]-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr) (SEQ ID NO:22);'}{'sub': '2', 'Dop 1(SO)-Lys[Dop1(SO)]-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:23);'}{'sub': 2', '2, 'Dop1(SO)-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe) (SEQ ID NO:24);'}{'sub': 2', '2, 'Dop1(SO)-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr) (SEQ ID NO:25);'}{'sub': 2', '2, 'Dop1(SO)-Tyr-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:26);'}{'sub': '2', 'Dop1-psi(CHNH)-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:28);'}Dop1-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe) (SEQ ID NO:29);Dop1-cyclo(DLys-Arg-Phe-4Pal- ...

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Номер записи: 30
26-02-2015 дата публикации

REFLECTIVE RELAY PROCESSING ON LOGICAL PORTS FOR CHANNELIZED LINKS IN EDGE VIRTUAL BRIDGING SYSTEMS

Номер: US20150055658A1
Автор: Abidi Vasmi M., Dong Xiang Hui, Sait Tamanna Z., SUN Yun, Zhu Zheng Dong
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

Embodiments of the invention relate to reflective relay (RR) processing on logical ports for channelized links in edge virtual bridging (EVB) systems. One embodiment includes providing a virtual edge bridge (VEB) mode and a virtual Ethernet port aggregator (VEPA) mode in an EVB system on a same port of a physical switch. RR capability per channel is negotiated between a server and the physical switch in the EVB system. RR per channel is supported on the physical switch of the EVB system using RR setting information per channel. 1. A method comprising:providing a virtual edge bridge (VEB) mode and a virtual Ethernet port aggregator (VEPA) mode in an edge virtual bridging (EVB) system on a same port of a physical switch;negotiating reflective relay (RR) capability per channel between a server and the physical switch in the EVB system; andsupporting RR per channel on the physical switch of the EVB system using RR setting information per channel.2. The method of claim 1 , wherein negotiating RR capability per channel comprises using a service virtual local area network (VLAN) identification (SVID) tag in a link layer discovery protocol (LLDP) packet for exchanging EVB LLDP trace EVB type claim 1 , length and value (TLV) exchange per service channel (S-channel).3. The method of claim 1 , wherein the LLDP packet format includes fields for the SVID tag and fields for LLDP EVB TLV.4. The method of claim 3 , wherein supporting RR per channel on the physical switch comprises supporting RR per S-channel.5. The method of claim 4 , wherein an extended table includes the RR setting information.6. The method of claim 4 , wherein the RR setting information is included in a modified egress VLAN (EGR_VLAN) table for indicating RR setting status for S-channels identified by port and service tag (S-tag).7. The method of claim 6 , further comprising:forwarding traffic to an ingress port of the physical switch;determining if the RR setting status for a particular S-channel that is ...

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Номер записи: 31
15-05-2014 дата публикации

Ambient Light Sensors with Infrared Compensation

Номер: US20140132578A1
Автор: ZHENG Dong
Принадлежит: Apple Inc.

An electronic device may have a display with a brightness that is adjusted based on ambient light data from one or more ambient light sensors. An ambient light sensor may include at least one silicon-based photosensor. The silicon-based photosensor may generate a corresponding raw sensor reading. Processing circuitry associated with the ambient light sensor may analyze the raw sensor reading to determine the type of light source that is present by comparing measurements from at least two different photosensors, by determining the color temperature of the light source, and/or by determining the modulation frequency of the light source. A compensation factor may then be selected by referring to a lookup table. The processing circuitry may compute a compensated sensor reading based on the raw sensor reading and the selected compensation factor. The brightness of the display may be adjusted based on the compensated sensor reading computed in this way. 1. A method of adjusting display brightness for a display in an electronic device that has an ambient light sensor and control circuitry while the electronic device is operated in an environment in which the electronic device is exposed to ambient light , the method comprising:measuring a total ambient light level for the ambient light with the ambient light sensor;processing ambient light data from the ambient light sensor to identify a lighting type associated with the ambient light; andwith the control circuitry, processing the total ambient light level using the identified lighting type to produce a visible light reading indicative of how much visible light is contained in the ambient light.2. The method defined in claim 1 , wherein the ambient light sensor includes a plurality of silicon photosensors claim 1 , and wherein measuring the total ambient light level comprises measuring the total ambient light level for the ambient light using the plurality of silicon photosensors.3. The method defined in claim 2 , further ...

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Номер записи: 32
15-05-2014 дата публикации

Ghrelin Analogs

Номер: US20140135260A1
Автор: Dong Zheng Xin, SHEN Yeelana
Принадлежит: IPSEN PHARMA S.A.S.

The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof. 2. The compound of claim 1 , wherein{'sup': '1', 'Ais Gly or Aib;'}{'sup': '2', 'Ais Ser, Aib, A5c, Act, or Ava;'}{'sup': 3', '4', '6', '7', '10', '11, 'sub': 2', '2, 'Ais Ser(C(O)—R), Glu(O—R), Glu(NH—R), Dap(S(O)—R), or Dab(S(O)—R);'}{'sup': '4', 'Ais Phe;'}{'sup': '5', 'Ais Leu, Acc, Aib, Cha, or hLeu;'}{'sup': '6', 'Ais Ser, Abu, Act, Aib, or Thr;'}{'sup': '7', 'Ais Pro, Dhp, Dmt, 4Hyp, Ktp, Pip, Tic, or Thz;'}{'sup': '8', 'Ais Glu or Aib;'}{'sup': '9', 'Ais His, Aib, Apc, 2Fua, 2Pal, 3Pal, 4Pal, Taz, or 2Thi;'}{'sup': '10', 'Ais Gln or Aib;'}{'sup': '11', 'Ais Arg;'}{'sup': '12', 'Ais Aib, Val or Acc;'}{'sup': '13', 'Ais Gln;'}{'sup': '14', 'Ais Gln;'}{'sup': '15', 'Ais Arg or Orn;'}{'sup': '16', 'Ais Lys or Apc;'}{'sup': '17', 'Ais Glu;'}{'sup': '18', 'Ais Ser;'}{'sup': '19', 'Ais Lys;'}{'sup': '20', 'Ais Lys;'}{'sup': '21', 'Ais Pro;'}{'sup': '22', 'Ais Pro;'}{'sup': '23', 'Ais Ala;'}{'sup': '24', 'Ais Lys;'}{'sup': '25', 'Ais Leu;'}{'sup': '26', 'Ais Gln;'}{'sup': '27', 'Ais Pro; and'}{'sup': '28', 'Ais Arg;'}or a pharmaceutically acceptable salt thereof.3. The compound of claim 2 , wherein{'sup': 2', '3, 'Rand Reach is, independently, H, Acyl, n-butyryl, isobutyryl, or n-octanoyl;'}{'sup': '4', 'Ris octyl;'}{'sup': '6', 'Ris hexyl;'}{'sup': '7', 'Ris hexyl;'}{'sup': '10', 'Ris octyl; and'}{'sup': '11', 'Ris octyl, wherein'}Acc is, independently for each occurrence, A5c or A6c;or a pharmaceutically acceptable salt thereof.4. The compound of claim 3 , selected from:{'sup': '3', 'sub': '2', '(Dap(Octanesulfonyl))hGhrelin(1-28)-NH(SEQ ID NO:4);'}{'sup': 2', '5, 'sub': '2', '(Aib, A6c)hGhrelin(1-28)-NH(SEQ ID NO:5);'}{'sup': '5', 'sub': '2', '(A6c)hGhrelin(1-28)-NH(SEQ ID NO:6);'}{'sup': '2,6', 'sub': '2', '(Aib)hGhrelin(1-28)-NH(SEQ ID NO:7);'}{'sup': 2', '12, 'sub': '2', '(Aib, A5c)hGhrelin(1-28)-NH(SEQ ID NO:8 ...

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Номер записи: 33
05-03-2015 дата публикации

METHODS AND APPARATUSES FOR ADJUSTING MACROBLOCK QUANTIZATION PARAMETERS TO IMPROVE VISUAL QUALITY FOR LOSSY VIDEO ENCODING

Номер: US20150063461A1
Автор: ZHENG Dong
Принадлежит: MAGNUM SEMICONDUCTOR, INC.

A method of encoding is provided. The method includes generating transform coefficients corresponding to macroblocks of video data, at least in part using a transform unit. The method also includes calculating a visual quality importance index for each of the macroblocks, wherein the visual quality importance index reflects a relative importance of the respective macroblock to subjective image quality. The method further includes receiving initial quantization parameters for the macroblocks from a rate control unit; dynamically adjusting the quantization parameters based, at least in part, on the visual quality importance index; and quantizing the transform coefficients using the dynamically adjusted quantization parameters. 1. A method of encoding comprising:generating transform coefficients corresponding to macroblocks of video data, at least in part using a transform unit;calculating a visual quality importance index for each of the macroblocks, wherein the visual quality importance index reflects a relative importance of the respective macroblock to subjective image quality;receiving initial quantization parameters for the macroblocks from a rate control unit;dynamically adjusting the quantization parameters based, at least in part, on the visual quality importance index; andquantizing the transform coefficients using the dynamically adjusted quantization parameters.2. The method of claim 1 , wherein calculating the visual quality importance index comprises calculating content complexity of the macroblocks based claim 1 , at least in part claim 1 , on activity of the macroblocks.3. The method of claim 2 , wherein calculating the visual quality importance index comprises identifying information based claim 2 , at least in part claim 2 , on the content complexity of the macroblocks4. The method of claim 1 , wherein calculating the visual quality importance index comprises calculating a luminance contrast index for each of the macroblocks based claim 1 , at least ...

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Номер записи: 34
28-02-2019 дата публикации

MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN

Номер: US20190062374A1
Автор: COMSTOCK Jeanne Mary, DEOLIVEIRA Daniel B., Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction. 7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of to and a pharmaceutically acceptable carrier or diluent; or a pharmaceutically acceptable salt thereof.8. A pharmaceutical composition according to claim 7 , wherein said compound is a selective melanocortin-4 receptor agonist; or a pharmaceutically acceptable salt thereof.9. A pharmaceutical composition according to claim 8 , wherein said compound is a selective melanocortin-4 receptor agonist with a functional activity characterized by an ECat least 15-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-1 receptor claim 8 , the human melanocortin-3 receptor and the human melanocortin-5 receptor; or a pharmaceutically acceptable salt thereof.10. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 17-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor; or a pharmaceutically acceptable salt thereof.11. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 90-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor; or a pharmaceutically acceptable salt thereof.12. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 200-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor; or a pharmaceutically ...

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Номер записи: 35
09-03-2017 дата публикации

Ambient Light Sensors with Auto Gain Switching Capabilities

Номер: US20170068303A1
Автор: Bommu Venkata Siva Sunil Kumar Reddy, Land Brian R., ZHENG Dong
Принадлежит:

An ambient light sensor that is operable in high gain mode and low gain mode is provided. The high gain mode may help provide satisfactory sensitivity at low light levels but may generate saturated output levels in bright ambient lighting conditions. Low gain mode may therefore be switched into use when bright ambient lighting conditions are detected. The ambient light sensor may be placed in high gain mode by default. An auto-gain switch controller may detect whether the ambient light reading is saturated during as given period of time in response to determining that the ambient light reading is saturated for a programmable number of consecutive time periods, the auto-gain switch controller may reset and switch the ambient light sensor to the low gain mode. The gain state may optionally be embedded into the ambient light sensor output. 1. An electronic device that is exposed to ambient light , comprising:a housing;control circuitry in the housing; and 'a persistency checking module that determines when an ambient light sensor output is saturated during a plurality of consecutive intervals to filter out high intensity pulses, wherein the ambient light sensor switches from a first gain state in the plurality of gain states to a second gain state in the plurality of gain states in response to determining that the ambient light sensor output is saturated during each of the plurality of consecutive intervals.', 'an ambient light sensor in the housing with which the control circuitry measures an ambient light intensity, wherein the ambient light sensor is operable in a plurality of gain states and comprises2. The electronic device defined in claim 1 , wherein the control circuitry selectively enables the ambient light sensor in an auto gain switching mode that allows the ambient light sensor to operate in the plurality of gain states.3. The electronic device defined in claim 1 , wherein the ambient light sensor comprises:an auto gain switching (AGS) control logic that ...

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Номер записи: 36
14-03-2019 дата публикации

Electronic Devices With Ambient Light Sensors

Номер: US20190080668A1
Автор: Holenarsipur Prashanth S., Isikman Serhan O., ZHENG Dong
Принадлежит:

An electronic device may be provided with a display mounted in a housing. The display may have an array of pixels that form an active area and may have an inactive area that runs along an edge of the active area. An opaque layer may be formed on an inner surface of a display cover layer in the inactive area of the display or may be formed on another transparent layer in the electronic device. An optical component window may be formed from the opening and may be aligned with an ambient light sensor such as a color ambient light sensor. The color ambient light sensor may have an infrared-blocking filter to block infrared light such as infrared light emitted by an infrared-light-emitting diode in the device. A light diffuser layer, light guide, and other structures may also be included in the ambient light sensor. 1. An ambient light sensor configured to provide ambient light measurements to control circuitry in an electronic device , the ambient light sensor comprising:a light detector integrated circuit;a light guide configured to guide ambient light to the light detector integrated circuit; andan infrared-blocking filter through which the ambient light passes.2. The ambient light sensor defined in further comprising a light diffuser claim 1 , wherein the light guide is interposed between the light diffuser and the infrared-blocking filter.3. The ambient light sensor defined in wherein the light guide includes a core and a cladding surrounding the core claim 2 , wherein the core has a first index of refraction and wherein the cladding has a second index of refraction that is less than the first index of refraction.4. The ambient light sensor defined in wherein the cladding comprises polymer claim 3 , the ambient light sensor further comprising an opaque support structure surrounding the light detector integrated circuit and the light guide.5. The ambient light sensor defined in wherein the light detector integrated circuit includes a plurality of photodetectors.6. ...

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Номер записи: 37
22-03-2018 дата публикации

TRANSFERRING DATA IN A GATEWAY

Номер: US20180083860A1
Автор: Li Yuan, Tang Gang, Zhu Zheng Dong
Принадлежит:

Transferring data by a gateway that is connected to a network with a SIMM-node. In response to a request to establish multi-MAC address routing information of a SIMM-node, multiple MAC addresses are obtained, corresponding to an IP address of the SIMM-node. The multi-MAC address routing information, including information in a route table, an ARP table, and a NEXT_HOP table, is established by adding to the ARP table corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node. The corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node is added to the NEXT_HOP table. Routing entries of the SIMM-node are established in the route table. In response to receiving a data message sent to the IP address of the SIMM-node, the message is routed by using the established multi-MAC address routing information of the SIMM-node. 1. A method of transferring data by a gateway , the gateway being connected to a network with a SIMM-node , the method comprising: obtaining multiple MAC addresses corresponding to an IP address of the SIMM-node; and', 'establishing the multi-MAC address routing information, comprising information in each of a route table, an ARP table, and a NEXT_HOP table to which a next-hop pointer in the route table points, by:', 'adding to the ARP table corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node;', 'adding to the NEXT_HOP table the corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node; and', 'establishing in the route table routing entries of the SIMM-node; and, 'in response to a request to establish multi-MAC address routing information of a SIMM-nodein response to having received a data message sent to the IP address of the SIMM-node, routing the data message by using the established multi-MAC address routing information of the SIMM-node.2. The method according to claim 1 , wherein routing the data ...

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Номер записи: 38
22-03-2018 дата публикации

TRANSFERRING DATA IN A GATEWAY

Номер: US20180083861A1
Автор: Li Yuan, Tang Gang, Zhu Zheng Dong
Принадлежит:

Transferring data by a gateway, the gateway being connected to a network with a SIMM-node. In response to a request to establish multi-MAC address routing information of a SIMM-node, obtaining multiple MAC addresses corresponding to an IP address of the SIMM-node. The multi-MAC address routing information of the SIMM-node is established at least according to the obtained multiple MAC addresses corresponding to the IP address of the SIMM-node. In response to having received a data message sent to the IP address of the SIMM-node, routing the data message by using the established multi-MAC address routing information of the SIMM-node. 1. A method of transferring data by a gateway , the gateway being connected to a network with a SIMM-node , the method comprising: [ ["sending sufficient multiple ARP request messages in a same subnet by using sufficient multiple reserved IP addresses as respective source IP address, using the gateway's MAC address as a source MAC address, and using the SIMM-node's IP address as a destination IP address; and", 'in response to having received sufficient multiple ARP response messages from the SIMM node, ignoring duplicated destination MAC addresses in the returned multiple ARP response messages;, 'obtaining multiple MAC addresses corresponding to an IP address of the SIMM-node by, 'establishing the multi-MAC address routing information of the SIMM-node at least according to the obtained multiple MAC addresses corresponding to the IP address of the SIMM-node; and, 'in response to a request to establish multi-MAC address routing information of a SIMM-nodein response to having received a data message sent to the IP address of the SIMM-node, routing the data message by using the established multi-MAC address routing information of the SIMM-node.2. The method according to claim 1 , wherein the multi-MAC address routing information at least comprises information in each of a route table claim 1 , an ARP table claim 1 , and a NEXT_HOP table to ...

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Номер записи: 39
23-03-2017 дата публикации

Electronic Device With Ambient Light Sensor Analog-to-Digital Converter

Номер: US20170084251A1
Автор: DONG Zheng
Принадлежит: Apple Inc

An electronic device may be provided with an ambient light sensor. An analog-to-digital converter may be used to digitize ambient light measurements made with the ambient light sensor. Control circuitry in the electronic device may be used to adjust the brightness of a display and take other actions in the electronic device based on the digitized ambient light measurements. The analog-to-digital converter may be a hybrid analog-to-digital converter having a most-significant-bit analog-to-digital converter circuit branch based on an integrating analog-to-digital converter and a least-significant-bit analog-to-digital converter circuit branch based on a successive-approximation-register analog-to-digital converter. The most-significant-bit branch may produce an output based a reset count for an integrator that is reset a number of times during a measurement period. The least-significant-bit branch may produce an output by digitizing an output from the integrator upon termination of the measurement period.

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Номер записи: 40
19-06-2014 дата публикации

Electronic Device With Display and Low-Noise Ambient Light Sensor

Номер: US20140166850A1
Автор: ZHENG Dong
Принадлежит: Apple Inc.

An electronic device may be provided that has a display. The display may produce stray light when producing images for a user. The electronic device may have an ambient light sensor for measuring ambient light levels. Ambient light data may be used in adjusting display brightness. The display may be periodically disabled to prevent the stray light from interfering with the ambient light sensor. An integrating analog-to-digital converter may be used in gathering sensor data from the ambient light sensor. Control circuitry may be configured to remove background signals from ambient light sensor data. The background signals may be associated with leakage current that arises due to offset voltages in an operational amplifier in the integrating analog-to-digital converter. The operational amplifier may have an analog autozeroing capability or control circuitry may be used to subtract background data from ambient light sensor data. 1. A method of gathering ambient light sensor data in an electronic device having a display , an ambient light sensor , and control circuitry with an integrating analog-to-digital converter , wherein the integrating analog-to-digital converter has an integrating input and wherein the control circuitry has transistor circuitry coupled between the integrating input and the ambient light sensor , the method comprising:with the control circuitry, disabling the display for sample periods and enabling the display for hold periods that are interspersed among the sample periods; andduring a first set of the sample periods, providing signals from the ambient light sensor to the integrating input through the transistor circuitry;during a second set of the sample periods, using the transistor circuitry to prevent signals from the ambient light sensor from reaching the integrating input; andwith the control circuitry, producing an ambient light sensor signal using data gathered by the integrating analog-to-digital converter during the second set of sample ...

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Номер записи: 41
25-03-2021 дата публикации

Electronic Devices Having Ambient Light Sensors With Hold Function

Номер: US20210090509A1
Автор: Chamakura Anand K., Motamed Ali, ZHENG Dong
Принадлежит:

An electronic device may have a display with an array of pixels configured to display images for a user. The electronic device may have an ambient light sensor for gathering ambient light information. The ambient light sensor may be at least partially covered by the display. The ambient light sensor may be switched into use during blanking periods when a portion of the display overlapping with the display is temporarily turned off. The ambient light sensor may include a photodetector, a first stage with an amplifier, first and second capacitors selectively coupled across the amplifier, and a second accumulation stage. During blanking time, the first capacitor may integrate photodetector current. During non-blanking, the charge stored in the first capacitor may be transferred to the second accumulation stage while the second capacitor applies an offset voltage to the photodetector to prevent undesired charge injection into the photodetector. 1. An electronic device , comprising:a display having rows of pixels; and a photosensitive element;', 'an integrating stage having an amplifier, a first feedback capacitor selectively coupled across the amplifier, and a second feedback capacitor selectively coupled across the amplifier, wherein the integrating stage is configured to integrate charge generated from the photosensitive element during a blanking period when at least some of the rows in the display overlapping with the ambient light sensor are not emitting light; and', 'an accumulation stage configured to receive signals from the integrating stage., 'an ambient light sensor at least partially overlapping with the display, wherein the ambient light sensor comprises2. The electronic device of claim 1 , wherein the charge integrated at the integrating stage during the blanking period is transferred to the accumulation stage during a non-blanking period when the at least some of the rows in the display overlapping with the ambient light sensor are emitting light.3. The ...

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Номер записи: 42
26-03-2020 дата публикации

Melanocortin Receptor Ligands

Номер: US20200095281A1
Автор: Dong Zheng Xin, MOREAU Jacques-Pierre
Принадлежит: IPSEN PHARMA S.A.S.

The present invention is directed to compounds according to formula, 5. A compound according to claim 4 , wherein said compound is:{'sub': '2', 'Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-β-Ala-Lys)-NH;'}{'sub': '2', 'Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-A6c-Lys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-His-D-Phe-Arg-Trp-Ahx-Cys)-NH;'}{'sub': '2', 'D-Phe-c(Cys-His-D-Phe-Arg-Trp-Ala-D-Cys)-Thr-NH;'}{'sub': '2', 'D-Phe-c(Cys-His-D-Phe-Arg-Trp-β-Ala-D-Cys)-Thr-NH;'}{'sub': '2', 'D-Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-D-Cys)-Thr-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-His-D-Phe-Arg-Trp-Apn-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Apn-Lys)-NH;'}{'sub': '2', 'Ac-A6c-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH;'}{'sub': '2', 'Ac-D-2-Nal-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH;'}{'sub': '2', 'Ac-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH;'}{'sub': '2', 'Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-β-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Gaba-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Aib-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Gly-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-β-Ala-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-Gaba-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-Aib-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-Gly-His-D-Phe-Arg-Trp-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-D-Ala-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-β-Ala-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Gaba-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Aib-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(Cys-Gly-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-Ala-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D-Cys-D-Ala-His-D-Phe-Arg-Trp-D-Cys)-NH;'}{'sub': '2', 'Ac-Nle-c(D ...

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Номер записи: 43
28-03-2019 дата публикации

Electronic Devices Having Ambient Light Sensors With Electrostatic Shields

Номер: US20190098748A1
Автор: Guo Dianbo, ZHENG Dong
Принадлежит:

An electronic device may be provided with a display. An opaque layer may be formed on an inner surface of a display cover layer in an inactive area of the display. An optical component window may be formed from the opening and may be aligned with an ambient light sensor such as a color ambient light sensor. The color ambient light sensor may have photodetectors on a light detector integrated circuit. Electrostatic shielding may be incorporated into the color ambient light sensor to prevent perturbations in the output of the color ambient light sensor due to the presence of electrostatic charge in the vicinity of the optical component window. The shielding may include a grounded shield layer on a surface of an ambient light sensor support structure that faces the display cover layer and may include a transparent shield layer overlapping the photodetectors. 1. An electronic device , comprising:a transparent member having an optical component window;a support structure having a surface facing the transparent member;a light detector integrated circuit coupled to the support structure;an electrostatic shield layer on the surface that is configured to shield the light detector; andoptical components in the support structure between the light detector an the transparent member.2. The electronic device defined in further comprising a signal path that is configured to short the electrostatic shield layer to a fixed potential.3. The electronic device defined in wherein the optical components comprise a light diffuser.4. The electronic device defined in wherein the optical component comprises a visible-light-transmitting-and-infrared-light-blocking filter.5. The electronic device defined in wherein the optical components comprises a light guide interposed between the light diffuser and the visible-light-transmitting and-infrared-light-blocking filter.6. The electronic device defined in wherein the support structure comprises a plastic support having an interior in which the ...

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Номер записи: 44
23-04-2015 дата публикации

METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE

Номер: US20150111823A1
Автор: Culler Michael DeWitt, Datta Rakesh, Dong Zheng Xin, Taylor John E
Принадлежит: IPSEN PHARMA S.A.S.

The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin. 13-. (canceled)4. A method of treating inflammation associated with an inflammatory disease of the gastrointestinal tract in a subject in need thereof which comprises administering to said subject an effective amount of a compound selected from the group consisting of:{'sub': '2', 'H-Inp-D-Bal-D-Trp-Phe-Apc-NH(SEQ ID: 2);'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-Phe-Lys-NH(SEQ ID: 144);'}{'sub': '2', 'H-Inp-D-2-Nal-D-Trp-Phe-Apc-NH(SEQ ID: 2);'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-Taz-Apc-NH(SEQ ID: 163);'}{'sub': '2', 'H-Inp-D-Bal-D-Trp-2-Thi-Apc-NH(SEQ ID: 208);'}{'sub': '2', 'H-Apc-D-1-Nal-D-Trp-2-Thi-Apc-NH(SEQ ID: 209);'}{'sub': '2', 'H-Apc-D-1-Nal-D-Trp-2-Thi-NH(SEQ ID: 159); and'}pharmaceutically acceptable salts thereof.5. The method of claim 4 , wherein said inflammatory disease of the gastrointestinal tract is selected from Crohn's disease claim 4 , inflammatory bowel disease claim 4 , ulcerative colitis claim 4 , and celiac disease.6. The method of claim 4 , wherein said inflammatory disease of the gastrointestinal tract is Crohn's disease.7. The method of claim 4 , wherein said inflammatory disease of the gastrointestinal tract is inflammatory bowel disease.8. The method of claim 4 , wherein said inflammatory disease of the gastrointestinal tract is ulcerative colitis.9. The method of claim 4 , wherein said inflammatory disease of the gastrointestinal tract is celiac disease. This application is a continuation application of U.S. Ser. No. 12/672,681, filed Feb. 8, 2010, which is a United States national stage filing under 35 U.S.C. §371 of international (PCT) application no. PCT/US2008/009494, filed Aug. 7, 2008, and designating the US, ...

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Номер записи: 45
19-04-2018 дата публикации

Melanocortin Receptor Ligands

Номер: US20180105557A1
Автор: Jacques-Pierre Moreau, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention is directed to compounds according to formula, (R 2 R 3 )-A 1 - c (A 2 -A 3 -A 4 -A 5 -A 6 -A 7 -A 8 -A 9 )-A 10 -R 1 , and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.

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Номер записи: 46
03-05-2018 дата публикации

MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN

Номер: US20180118784A1
Автор: COMSTOCK Jeanne Mary, DEOLIVEIRA Daniel B., Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction. 250-. (canceled) This application is a continuation application filed under 35 U.S.C. § 111, claiming priority to U.S. patent application Ser. No. 14/024,961 filed Sep. 12, 2013, which is a divisional application filed under 35 U.S.C. § 111, claiming priority to U.S. patent application Ser. No. 12/602,010 filed Nov. 25, 2009 which issued as U.S. Pat. No. 8,563,000 and claims priority to United States national stage application filed under 35 U.S.C. § 371 of international (PCT) application no. PCT/US08/06675 filed May 23, 2008, and designating the US, which claims priority to U.S. provisional application No. 60/931,784 filed May 25, 2007.The present invention relates to a series of new melanocortin receptor ligands useful in treating diseases responsive to modulation of such receptors. The invention also relates to pharmaceutical compositions comprising such peptide analogs and to their use in the prevention or treatment of conditions affected by such receptors.Melanocortins are a family of regulatory peptides which are formed by post-translational processing of pro-hormone pro-opiomelanocortin (POMC; 131 amino acids in length). POMC is processed into three classes of hormones; the melanocortins, including but not limited to α-MSH (melanocyte stimulating hormone), β-MSH and γ-MSH, adrenocorticotropin hormone (ACTH), various endorphins (e.g. lipotropin) (Cone, R. D. et al., 51:287-317 (1996); and Cone, R. D. et al., 31:342-63 (1993)) and their peptide fragments. Melanocortins have been found in a wide variety of normal human tissues including the brain, adrenal, skin, testis, spleen, kidney, ovary, lung, thyroid, liver, colon, small intestine and pancreas (Tatro, J. B. et al., 121:1900-7 ( ...

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Номер записи: 47
25-08-2022 дата публикации

METHOD OF TRAINING PREDICTION MODEL, PREDICTION METHOD, ELECTRONIC DEVICE AND MEDIUM

Номер: US20220269952A1
Автор: CHENG Yihang, DONG Zheng, Zhang Xi, ZHAO Hongke, ZHU Hengshu
Принадлежит:

Provided are a method of training a prediction model, a prediction method, an electronic device and a medium, which relate to the field of artificial intelligence technology, and in particular, to the field of Big Data. A prediction model includes a main prediction model and an auxiliary prediction model, a training sample set includes a project information sample of a project and an item information sample of an item associated with the project, a project information sample includes a project property information and a project comment information, and an item information sample includes an item comment information. The method includes: inputting the project comment information to the auxiliary prediction model to obtain an initial prediction semantic information; training the main prediction model by using the project property information and the initial prediction semantic information; and training the auxiliary prediction model by using the item comment information. 1. A method of training a prediction model by using a training sample set , wherein the prediction model comprises a main prediction model and an auxiliary prediction model , the training sample set comprises a project information sample of a project and an item information sample of an item associated with the project , the project information sample comprises a project property information and a project comment information , and the item information sample comprises an item comment information , and the method comprises:inputting the project comment information to the auxiliary prediction model to obtain an initial prediction semantic information corresponding to the project comment information;training the main prediction model by using the project property information and the initial prediction semantic information corresponding to the project comment information; andtraining the auxiliary prediction model by using the item comment information.2. The method according to claim 1 , wherein the ...

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Номер записи: 48
03-06-2021 дата публикации

MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN

Номер: US20210163536A1
Автор: COMSTOCK Jeanne Mary, DEOLIVEIRA Daniel B., Dong Zheng Xin
Принадлежит:

The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction. 7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of to and a pharmaceutically acceptable carrier or diluent; or a pharmaceutically acceptable salt thereof.8. A pharmaceutical composition according to claim 7 , wherein said compound is a selective melanocortin-4 receptor agonist; or a pharmaceutically acceptable salt thereof.9. A pharmaceutical composition according to claim 8 , wherein said compound is a selective melanocortin-4 receptor agonist with a functional activity characterized by an ECat least 15-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-1 receptor claim 8 , the human melanocortin-3 receptor and the human melanocortin-5 receptor; or a pharmaceutically acceptable salt thereof.10. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 17-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor; or a pharmaceutically acceptable salt thereof.11. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 90-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor; or a pharmaceutically acceptable salt thereof.12. A pharmaceutical composition according to claim 9 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 200-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor; or a pharmaceutically ...

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Номер записи: 49
28-05-2015 дата публикации

SOMATOSTATIN-DOPAMINE CHIMERIC ANALOGS

Номер: US20150148522A1
Автор: Dong Zheng Xin, SHEN Yeelana
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions. 12-. (canceled)5. The method of claim 3 , wherein said neuroendocrine tumor is a neuroendocrine tumor of the pituitary.6. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is an ACTH-producing tumor.7. The method of claim 6 , wherein the condition of said ACTH-producing tumor is Cushing's disease.8. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is a growth hormone producing tumor.9. The method of claim 8 , wherein the condition of said growth hormone producing tumor is acromegaly.10. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is a prolactin-producing tumor.11. The method of claim 10 , wherein the condition of said prolactin-producing tumor is a prolactinoma.12. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is hyperprolactinemia.13. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is thyroid stimulating hormone secreting tumor.14. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is “nonfunctioning” pituitary adenoma.15. The method of claim 5 , wherein said neuroendocrine tumor of the pituitary is gonadotropinoma.16. The method of claim 3 , wherein the neuroendocrine tumor is carcinoid tumor.17. The method of claim 16 , wherein said carcinoid tumor causes carcinoid syndrome.18. The method of claim 3 , wherein said neuroendocrine tumor is glucagonoma.19. The method of claim 3 , wherein said neuroendocrine tumor is small cell lung carcinoma.20. The method of claim 3 , wherein said neuroendocrine tumor is thyroid medullary carcinoma.21. The method of claim 3 , wherein said neuroendocrine tumor is VIPoma.22. The method of claim 3 , wherein said neuroendocrine tumor is ...

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Номер записи: 50
28-08-2014 дата публикации

PNEUMATIC VEHICLE TIRE

Номер: US20140238573A1
Автор: Bartke Joerg, Herta Katie, ZHENG Dong
Принадлежит: CONTINENTAL REIFEN DEUTSCHLAND GMBH

A pneumatic vehicle tire of a radial type of construction is for heavy trucks and has a four-ply belt (). Each belt ply () contains steel cords as reinforcing elements which run parallel to one another in each belt ply. Not only are the angles (β, γ) that the steel cords in the second and third belt plies () form with the circumferential direction (A-A) approximately equal, but also the angles (α, δ) that the steel cords in the first and fourth belt plies () form with the circumferential direction (A-A) are likewise approximately equal. 1. A pneumatic vehicle tire having a radial configuration for heavy trucks and defining a circumferential direction A-A , the pneumatic vehicle tire comprising:a four ply belt having a radially innermost first belt ply, a second belt ply, a third belt ply and a fourth belt ply;said first, second, third and fourth belt ply each including steel cords configured as reinforcement members;said steel cords of each of said first belt ply, said second belt ply, said third belt ply and said fourth belt ply running parallel to the other steel cords of the same belt ply;said steel cords of said first, second, third and fourth belt plies having a predetermined slope sequence of rightward increasing (R) and leftward increasing (L) slope with respect to the circumferential direction A-A starting with said steel cords of said radially innermost first belt ply;said steel cords of said second belt ply enclosing an angle (β) with the circumferential direction A-A;said steel cords of said third belt ply enclosing an angle (γ) with the circumferential direction A-A;said angle (β) and said angle (γ) being approximately equal;said steel cords of said first belt ply enclosing an angle (β) with the circumferential direction A-A;said steel cords of said fourth belt ply enclosing an angle (δ) with the circumferential direction A-A; and,said angle (β) and said angle (δ) being approximately equal.2. The pneumatic vehicle tire of claim 1 , wherein said angle (β) ...

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Номер записи: 51
18-06-2015 дата публикации

SELECTIVE CARTILAGE THERAPY

Номер: US20150166628A1
Автор: Dong Zheng Xin, Lee Richard T., Loffredo Francesco, Pancoast James, Patwari Parth, Vannelli Todd
Принадлежит:

The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fusion proteins in methods to deliver IGF-1 to the cartilage for the treatment of a cartilage related disease and disorder in a subject. 1. A composition comprising a HB-X fusion protein , wherein HB is a heparin binding peptide having the amino acid sequence (MKRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:1) or (KRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:2) , and X is Insulin-like growth factor 1 (IGF-1) , or functional portion , variant , analog , or derivative thereof.219.-. (canceled)20. The composition of claim 1 , wherein the IGF-1 is a human IGF-1.212. A method of treating a cartilage-related condition comprising administering to a subject an effective amount of a fusion protein of or .22. The method of claim 21 , wherein the cartilage-related condition is a articular cartilage defect including rupture or detachment claim 21 , a meniscal defect including a partial or complete tear claim 21 , Osteoarthritis claim 21 , Traumatic cartilage rupture or detachment claim 21 , Ankylosing spondylitis claim 21 , Capsulitis claim 21 , Psoriatic arthritis claim 21 , Rheumatoid arthritis claim 21 , Systemic lupus erythematosus claim 21 , Juvenile idiopathic arthritis claim 21 , or X-linked hypophosphatemic rickets.23. The composition of claim 1 , wherein the IGF-1 comprises the amino acid sequence of SEQ ID NO: 4 claim 1 , 5 claim 1 , 6 or 7.24. The composition of claim 1 , wherein the IGF-1 comprises the amino acid sequence of SEQ ID NO: 4 claim 1 , 5 claim 1 , 6 or 7.25. The composition of claim 1 , wherein the HB is fused to the N-terminus of IGF-1.26. The composition of claim 1 , wherein the HB is ...

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Номер записи: 52
14-06-2018 дата публикации

Novel Formulations of PTHrP Analogue

Номер: US20180161401A1
Автор: Dong Zheng Xin
Принадлежит:

The present invention provides a non-buffered, neutral pH easily prepared, storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition has a non-buffered neutral pH which avoids injection site reactions and is easy to prepare and storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients. 1. A composition suitable for administration to a subject comprising a PTHrP analogue having the sequence [Glu , Leu , Aib , Lys]hPTHrP(1-34)NH(SEQ ID NO.2) ,wherein the pH of the composition is in a range of about 3.5 to about 8.5;provided that wherein said composition does not contain an effective amount of a pH buffer for maintaining the pH from about 6.0 to about 8.0.2. (canceled)3. A composition according to claim 1 , wherein said pH is about 6.5.4. A composition according to claim 1 , further comprising an effective amount of an antimicrobial agent claim 1 , wherein said antimicrobial agent maintains the stability of said composition for storage prior to use.5. A storage-stable composition according to claim 4 , wherein said anti-microbial agent is phenol.6. A composition according to claim 5 , wherein said phenol is present in a concentration from about 0.25 mg/mL to about 7 mg/mL.7. A composition according to claim 5 , wherein said phenol is present in a concentration of about 5 mg/mL.8. A composition according to claim 1 , wherein said PTHrP analogue is present in a concentration from about 0.1 mg/mL to about 10.0 mg/mL.9. A composition according to claim 1 , wherein said PTHrP analogue is present in a concentration from about 1.0 mg/mL to about 2.0 mg/mL.10. A composition according to claim 1 , further comprising an effective amount of an isotonic agent.11. A ...

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Номер записи: 53
23-06-2016 дата публикации

Melanocortin receptor ligands modified with hydantoin

Номер: US20160176925A1
Автор: Daniel B. Deoliveira, Jeanne Mary Comstock, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.

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Номер записи: 54
29-09-2022 дата публикации

Laser Safety Circuit Providing Frequency-Based Average Current Monitoring

Номер: US20220311211A1
Автор: Sweet Stephen N., ZHENG Dong
Принадлежит:

A method of operating a laser includes generating a first signal having a first frequency, and generating a second signal having a second frequency. The first frequency varies in accord with an amplitude of a drive current provided to a laser. The method further includes incrementing or decrementing a count responsive to a relationship between the first frequency and the second frequency; determining the count satisfies a threshold count; and modifying operation of the laser when the count satisfies the threshold count. 1. A laser safety circuit , comprising:a current-to-frequency converter configured to generate a first signal modulated at a first frequency, the first frequency varying in accord with an amplitude of a drive current provided to a laser;an oscillator configured to generate a second signal having a second frequency;an up/down counter configured to periodically increment or decrement a count responsive to a relationship between the first frequency and the second frequency, and assert an average current trip signal when the count satisfies a threshold count; anda control circuit configured to modify operation of the laser responsive to the assertion of the average current trip signal.2. The laser safety circuit of claim 1 , further comprising:a current source; and a first leg coupled to the current source;', 'a second leg operable to carry the drive current; and', 'a third leg coupled to an input of the current-to-frequency converter., 'a current mirror having,'}3. The laser safety circuit of claim 2 , wherein the current mirror has a programmable gain for mirroring current to the third leg.4. The laser safety circuit of claim 3 , further comprising:a register storing a value that determines the programmable gain for mirroring current to the third leg.5. The laser safety circuit of claim 2 , further comprising:a first multiplexer configured to couple the laser into the second leg of the current mirror, the laser selected from a set of lasers;a set of up ...

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Номер записи: 55
18-09-2014 дата публикации

Ambient Light Sensors with Photodiode Leakage Current Compensation

Номер: US20140267202A1
Автор: ZHENG Dong
Принадлежит: Apple Inc.

An electronic device may have a display with a brightness that is adjusted based on data gathered from one or more ambient light sensors (ALSs). In one suitable arrangement, an ALS may include a photodiode, a temperature sensor, a scaler, an analog-to-digital converter (ADC), and a subtractor. The subtractor may have a first input coupled to the photodiode via the ADC, a second input coupled to the temperature sensor via the scaler, and an output on which a leakage-compensated sensor output is provided. In another suitable arrangement, the ALS may include first and second photodiodes, a light blocking layer formed over the second photodiode, a scaler, and a subtractor. The subtractor may have a first input coupled to the first photodiode, a second input coupled to the second photodiode via the scaler, and an output on which a leakage-compensated sensor output is provided. 1. An electronic device , comprising:an ambient light sensor that includes a photosensitive element and a temperature sensor, wherein the ambient light sensor is configured to generate a leakage-compensated output signal based on information gathered from the photosensitive element and the temperature sensor.2. The electronic device defined in claim 1 , further comprising:a display having an adjustable brightness level, wherein the brightness level of the display is adjusted based on the leakage-compensated output signal.3. The electronic device defined in claim 1 , wherein the photosensitive element comprises a photodiode.4. The electronic device defined in claim 1 , wherein the ambient light sensor further includes:a scaler circuit that receives a temperature sensor output signal from the temperature sensor, wherein the scaler circuit produces a corresponding scaled leakage current signal based on the temperature sensor output signal.5. The electronic device defined in claim 4 , wherein the ambient light sensor further includes:an analog-to-digital converter having an input that is coupled to the ...

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Номер записи: 56
20-06-2019 дата публикации

Solar-powered decorative light system, decorative light apparatus, and a method of controlling a decorative light apparatus

Номер: US20190186704A1
Автор: Fei Qiu, Guo Dong Zheng
Принадлежит: Evergreen Enterprises of Virginia LLC

A solar-powered decorative light system, a decorative light apparatus, and a method of controlling a decorative light apparatus. The solar-powered light system includes kinetic, balancing decorative items having controllable light sources that illuminate to give a “chasing light” visual effect that is automatically illuminated in response to movement of the decorative items. The illumination of the light sources is configured to correlate or is otherwise synchronized in relation to movement of the decorative items.

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Номер записи: 57
21-07-2016 дата публикации

METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE

Номер: US20160206700A1
Автор: John E. Taylor, Michael Dewitt Culler, Rakesh Datta, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin.

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Номер записи: 58
06-08-2015 дата публикации

Composition and Methods for Stimulating Gastrointestinal Motility

Номер: US20150218245A1
Автор: Rakesh Datta, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

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Номер записи: 59
04-08-2016 дата публикации

Pharmaceutical Compositions of Growth Hormone Secretagogue Receptor Ligands

Номер: US20160220637A1
Автор: Dong Zheng Xin, Zhang Jundong
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to improvements in compositions containing peptides that are ligands of the GHS receptor, or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and methods of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of H-Inp-D-Bal-D-Trp-Phe-Apc-NH, which is a ligand of the GHS receptor and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms an in situ depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol with an average molecular weight of lower than 1000. 12-. (canceled)4. The pharmaceutical composition according to claim 3 , wherein said peptide is H-Inp-D-Bal-D-Trp-Phe-Apc-NH.58-. (canceled)9. The pharmaceutical composition according to claim 3 , wherein said PEG has an average molecular weight of from about 200 to about 10 claim 3 ,000.10. (canceled)11. The pharmaceutical composition according to claim 3 , wherein said peptide is dissolved in a PEG200 or PEG400 aqueous solution claim 3 , in which the volume-to-volume ratio of PEG to water is from about 1:9 to about 1:1.12. (canceled)13. The pharmaceutical composition according to claim 3 , wherein the weight-to-volume concentration of said peptide is between about 0.1 mg/mL and about 2000 mg/mL.14. The pharmaceutical composition according to claim 3 , wherein the pH of said composition is between about 3.0 and about 8.0.15. The pharmaceutical composition according to claim 14 , wherein said pamoate salt of H-Inp-D-Bal-D-Trp-Phe-Apc-NHis dissolved in a PEG400/aqueous solution claim 14 , in which the volume-to-volume ratio of PEG400 to water is about 1:1 claim 14 , and in which the weight-to-volume concentration of the peptide is about 200 mg/mL.16. The ...

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Номер записи: 60
11-08-2016 дата публикации

METHODS AND APPARATUS FOR RAPID SWITCHING OF HARDWARE CONFIGURATIONS WITH A SPEED LIMITED BUS

Номер: US20160232124A1
Автор: Bommu Venkata Siva Sunil Kumar Reddy, Colosimo Joseph William, ZHENG Dong
Принадлежит:

Methods and apparatus for enabling rapid transactions over a speed limited bus are disclosed. In one exemplary embodiment of the present disclosure, a host controller and an application specific integrated circuit (ASIC) are connected via an Inter-Integrated Circuit (I2C) Bus that is further adapted to enable a simplified signaling scheme. Unlike traditional I2C bus transactions which are flexible but speed limited, the simplified signaling scheme reduces bus overhead and enables rapid transactions. In an exemplary context, the simplified signaling scheme enables the ASIC to rapidly configure a series of photodiodes with different channel gain parameters so as to, for example, measure heartbeats by visually detecting a pulse within human flesh. 1. A method for enabling rapid transactions over a speed limited bus , comprising:pre-loading a series of parameters into a component;enabling a simplified signaling protocol;causing the component to perform one or more operations with the series of parameters, based on the simplified signaling protocol; andupon completion of the one or more operations, disabling the simplified signaling protocol.2. The method of claim 1 , where the pre-loading is performed according to a first protocol; andwhere the first protocol enables at least one capability that the simplified signaling protocol does not enable.3. The method of claim 2 , where the at least one capability is selected from the group consisting of: addressing claim 2 , flow control claim 2 , bus arbitration claim 2 , acknowledgment/non-acknowledgement claim 2 , and power control.4. The method of claim 2 , where the first and simplified signaling protocols are mutually exclusive.5. The method of claim 2 , where the first and simplified signaling protocols coexist.6. The method of claim 1 , where the one or more operations comprise a mutually-agreed-upon context characterized by a specific purpose.7. The method of claim 6 , where the specific purpose comprises performing a ...

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Номер записи: 61
25-07-2019 дата публикации

Dynamic Bandwidth Allocation for Wireless Mesh Networks

Номер: US20190229994A1
Автор: Efron Adam Joshua, Gopala Praveen Kumar, Nemavat Pradeep Jugraj, ZHENG Dong
Принадлежит:

Apparatuses, methods, and systems for dynamic bandwidth allocation are disclosed. One method includes identifying, by a first distribution node of a wireless mesh network, a communication link with a second distribution node of the wireless mesh network, generating, by the first distribution node, a proposed bandwidth allocation schedule for wireless communication of information between the first distribution node and the second distribution node based on data traffic requirements of the first distribution node, wherein the second distribution node receives the proposed bandwidth allocation schedule, and wherein the second distribution node adjusts the proposed bandwidth allocation schedule based upon data traffic requirements of the second distribution node. The method further includes receiving, by the first distribution node, the adjusted proposed bandwidth allocation schedule from the second distribution node, and communicating, by the first distribution node, information with the second distribution node according to the adjusted proposed bandwidth allocation schedule. 1. A method , comprising:identifying, by a first distribution node of a wireless mesh network, a communication link with a second distribution node of the wireless mesh network;generating, by the first distribution node, a proposed bandwidth allocation schedule for wireless communication of information between the first distribution node and the second distribution node based on data traffic requirements of the first distribution node;wherein the second distribution node receives the proposed bandwidth allocation schedule, and wherein the second distribution node adjusts the proposed bandwidth allocation schedule based upon data traffic requirements of the second distribution node;receiving, by the first distribution node, the adjusted proposed bandwidth allocation schedule from the second distribution node; andcommunicating, by the first distribution node, information with the second ...

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Номер записи: 62
24-08-2017 дата публикации

Melanocortin Receptor Ligands

Номер: US20170240595A1
Автор: Dong Zheng Xin, MOREAU Jacques-Pierre
Принадлежит: IPSEN PHARMA S.A.S.

The present invention is directed to compounds according to formula, 19. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of to , or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier or diluent.20. A pharmaceutical composition according to claim 19 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof.21. A pharmaceutical composition according to claim 20 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof with a functional activity characterized by an ECat least 15-fold more selective for the human melanocortin 4 receptor than for the human melanocortin-1 receptor claim 20 , the human melanocortin-3 receptor and the human melanocortin-5 receptor.22. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 17-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.23. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 90-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.24. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 200-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.25. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 3000-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.26. A pharmaceutical composition according to useful ...

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Номер записи: 63
10-09-2015 дата публикации

AIRLESS AND RUNFLAT TIRE STRUCTURES, COMPONENTS AND ASSEMBLY TECHNIQUES

Номер: US20150251493A1
Автор: Ma Zheng-Dong
Принадлежит:

An auxetic wheel according to the invention comprises a line defining an axis of rotation; and a plurality of concentric rings of unit cells surrounding the axis, each unit cell being constructed of a plurality of members defining a Negative Poisson's Ratio (NPR) structure. The outermost ring of unit cells is arranged to facilitate rolling terrain contact, such that the stiffness of the structure in the localized region of loading due to terrain contact increases as the wheel rotates. A layer of material may be disposed between the concentric rings of unit cells which in preferred embodiments comprise a plurality of nested-V shapes. A cover may be provided over the outermost ring of unit cells forming a tire which may, or may not, be inflated. 1. An airless , run-flat tire structure , comprising:an inner rim having a width and a central axis of rotation;an outer tread structure; anda ring of V-shaped structural members disposed circumferentially between the inner rim and the outer tread structure, each structural member comprising two panels joined at a common edge forming a V-shaped cross section, with the other edge of each panel terminating in a pair opposing edges, each V-shaped structural member having a height defined as the distance between a plane tangent to its opposing edges and its common edge.2. The airless claim 1 , run-flat tire structure of claim 1 , wherein the common edges of the V-shaped structural members are oriented toward the outer tread structure and the opposing edges are oriented toward the inner rim.3. The airless claim 1 , run-flat tire structure of claim 1 , including:two or more concentric rings of V-shaped structural members; anda concentric belt disposed between one or more of the concentric rings of V-shaped structural members.4. The airless claim 1 , run-flat tire structure of claim 1 , wherein the V-shaped structural members are metal or other rigid material.5. The airless claim 2 , run-flat tire structure of claim 2 , including a ...

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Номер записи: 64
10-09-2015 дата публикации

Somatostatin Analogs and Dimers Thereof

Номер: US20150252078A1
Автор: Dong Zheng Xin, Ferrandis Eric
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to novel somatostatin analogs, dimers thereof, and methods of using the same to treat various diseases. Naturally occurring somatostatins (SSTs), which are also known as somatotropin release-inhibiting factors (SRIFs), have diverse biological effects in many cells and organs 10 throughout the body. They are produced by normal endocrine, gastrointestinal, immune and neuronal cells, as well as by certain tumors (Patel, Y. C, Frontiers in Neuroendocrinology, 20(3): 157-198 (1999); Froidevaux, et al., Biopolymers, 66(3): 161-83 (2002)). 1. A compound according to Formula I ,{'br': None, 'sup': 1', '5', '9, 'A-cyclo(DLys-Arg-Phe-A-DTrp-Lys-Thr-A)\u2003\u2003(I)'} [{'sup': '1', 'Ais DTyr, Tyr, DLys, Lys, D2Nal, 2Nal, D1Nal, 1Nal, or absent;'}, {'sup': '5', 'Ais Phe, 2Pal, 3Pal, or 4Pal;'}, {'sup': '9', 'Ais Phe, 2FPhe, 3FPhe, 4FPhe, 3,4FPhe, 3,5FPhe, 2,3,4,5,6FPhe, or Tyr; and'}, {'sup': '1', 'sub': '1-10', 'Ais optionally acylated with RC(O), wherein R is Calkyl;'}], 'whereinor a pharmaceutically acceptable salt thereof.2. The compound according to claim 1 , wherein said compound is:cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe);cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-Phe);cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr);cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe);DTyr-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-Phe);DTyr-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr);DTyr-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe);Tyr-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe);Tyr-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-Phe);Tyr-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr);Tyr-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe);D2Nal-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe);D2Nal-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-Phe);D2Nal-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr);D2Nal-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe);2Nal-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Phe);2Nal-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-Phe);2Nal-cyclo(DLys-Arg-Phe-4Pal-DTrp-Lys-Thr-Tyr);2Nal-cyclo(DLys-Arg-Phe-Phe-DTrp-Lys-Thr-4FPhe); ...

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Номер записи: 65
10-09-2015 дата публикации

ANALOGUES OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE

Номер: US20150252092A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

There is provided a series of glucose-dependent insulinotropic polypeptide analog compounds, pharmaceutical compositions, and the use of the GIP polypeptide analog compounds as GIP-receptor agonists or antagonists for the treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity. 2. A compound according to claim 1 , wherein:{'sup': '1', 'sub': 2', '12', '3, 'Ais Tyr, 4Hppa, or Orn(N—C(O)—(CH)—CH);'}{'sup': '2', 'Ais Ala, A5c, A6c, Aib, D-Ala, Gly, or Ser;'}{'sup': '3', 'Ais Glu, Dhp, 3Hyp, 4Hyp, Pro, hPro, or Tic;'}{'sup': '4', 'Ais Gly or Aib;'}{'sup': '5', 'Ais Thr, A5c, or Aib;'}{'sup': '6', 'Ais Phe or A6c;'}{'sup': '7', 'Ais Ile, A5c, A6c, or Aib;'}{'sup': '8', 'Ais Ser or Aib;'}{'sup': '9', 'Ais Asp or Aib;'}{'sup': '10', 'Ais Tyr;'}{'sup': '11', 'Ais Ser, A5c, A6c, Aib, or Nle;'}{'sup': '12', 'Ais Ile, A5c, or Aib;'}{'sup': '13', 'Ais Ala or Aib;'}{'sup': '14', 'Ais Met, A5c, A6c, or Nle;'}{'sup': '15', 'Ais Asp;'}{'sup': '16', 'Ais Lys;'}{'sup': '17', 'Ais Ile or A6c;'}{'sup': '18', 'Ais His;'}{'sup': '19', 'Ais Gln;'}{'sup': '20', 'Ais Gln;'}{'sup': '21', 'Ais Asp;'}{'sup': '22', 'Ais Phe;'}{'sup': '23', 'Ais Val;'}{'sup': '24', 'Ais Asn;'}{'sup': '25', 'Ais Trp;'}{'sup': '26', 'Ais Leu or A6c;'}{'sup': '27', 'Ais Leu or A6c;'}{'sup': '28', 'Ais Ala or Aib;'}{'sup': '29', 'Ais Gln;'}{'sup': '30', 'Ais Lys;'}{'sup': '31', 'Ais Gly, Aib, Cys(Psu), His, or deleted;'}{'sup': '32', 'Ais Lys, Cys(Psu), or deleted;'}{'sup': '33', 'Ais Lys, Cys(Psu), or deleted;'}{'sup': '34', 'Ais Asn, Cys(Psu), or deleted;'}{'sup': '35', 'Ais Asp, Cys(Psu), or deleted;'}{'sup': '36', 'Ais Trp, Cys(Psu), or deleted;'}{'sup': '37', 'Ais Lys, Cys(Psu), or deleted;'}{'sup': '38', 'Ais His, Cys(Psu), or deleted;'}{'sup': '39', 'Ais Asn, Cys(Psu), or deleted;'}{'sup': '40', 'Ais Ile, A5c, A6c, Cys(Psu), or deleted;'}{'sup': '41', 'Ais Thr, A5c, A6c, Aib, Cys(Psu), or deleted;'}{'sup': '42', 'Ais Gln or deleted;'}{'sup': '43', 'Ais Cys( ...

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Номер записи: 66
10-09-2015 дата публикации

GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGUES

Номер: US20150252093A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide compounds, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP-receptor agonists or antagonists for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity. 2. A compound according to claim 1 , wherein:{'sup': '4', 'Ais Gly;'}{'sup': '5', 'Ais Thr;'}{'sup': '6', 'Ais Phe;'}{'sup': '7', 'Ais Ile or A6c;'}{'sup': '8', 'Ais Ser;'}{'sup': '9', 'Ais Asp;'}{'sup': '10', 'Ais Tyr;'}{'sup': '11', 'Ais Ser, A5c, or A6c;'}{'sup': '12', 'Ais Ile;'}{'sup': '13', 'Ais Ala or Aib;'}{'sup': '14', 'Ais Met, A5c, A6c, or Nle;'}{'sup': '15', 'Ais Asp;'}{'sup': '16', 'Ais Lys;'}{'sup': '17', 'Ais Ile;'}{'sup': '18', 'Ais His;'}{'sup': '19', 'Ais Gln;'}{'sup': '20', 'Ais Gln;'}{'sup': '21', 'Ais Asp;'}{'sup': '22', 'Ais Phe;'}{'sup': '23', 'Ais Val;'}{'sup': '24', 'Ais Asn;'}{'sup': '25', 'Ais Trp;'}{'sup': '26', 'Ais Leu;'}{'sup': '27', 'Ais Leu;'}{'sup': '28', 'Ais Ala;'}{'sup': '29', 'Ais Gln;'}{'sup': '30', 'Ais Lys;'}{'sup': '31', 'sub': 2', '12', '3, 'Ais Gly, His, Orn(N—C(O)—(CH)—CH), or deleted;'}{'sup': '32', 'sub': 2', '11', '3', '2', '15', '3', '2', '10', '3', '2', '14', '3, 'Ais Lys, Cys, Cys(succinimide-N—(CH)—CH), Cys(succinimide-N—(CH)—CH), Orn(N—C(O)—(CH)—CH), Orn(N—C(O)—(CH)—CH), or deleted;'}{'sup': '33', 'sub': 2', '11', '3', '2', '15', '3', '2', '10', '3', '2', '14', '3, 'Ais Lys, Cys, Cys(succinimide-N—(CH)—CH), Cys(succinimide-N—(CH)—CH), Orn(N—C(O)—(CH)—CH), or Orn(N—C(O)—(CH)—CH), or deleted;'}{'sup': '34', 'Ais Asn or deleted;'}{'sup': '35', 'sub': 2', '12', '3, 'Ais Asp, Orn(N—C(O)—(CH)—CH), or deleted;'}{'sup': '36', 'Ais Trp or deleted;'}{'sup': '37', 'Ais Lys or deleted;'}{'sup': '38', 'Ais His or deleted;'}{'sup': '39', 'Ais Asn or deleted;'}{'sup': '40', 'Ais Ile, A5c, A6c, or deleted;'}{'sup': '41', 'Ais Thr, A5c, A6c, or deleted;'}{'sup': '42', 'Ais Gln, Cys(Psu), or ...

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Номер записи: 67
15-08-2019 дата публикации

Composition and Methods for Stimulating Gastrointestinal Motility

Номер: US20190248861A1
Автор: Datta Rakesh, Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient. 137-. (canceled)39. The method of claim 38 , wherein:{'sup': '2', 'Ais Aib, Acc, or Act;'}{'sup': 3', '10', '11, 'sub': 2', '2, 'Ais Dap(S(O)—R), Dab(S(O)—R), Glu(NH-Hexyl), or Cys(S-Decyl);'}{'sup': '5', 'Ais Abu, Acc, Aib, Ala, Cha, Ile, hLeu, Nle, Nva, Phe, Tle, or Val;'}{'sup': '6', 'Ais Abu, Acc, Act, Aib, Ala, Gly, Thr or Val;'}{'sup': '7', 'Ais Dhp, Dmt, 3-Hyp, 4-Hyp, Inc, Ktp, Oic, Pip, Thz or Tic;'}{'sup': 8', '12', '13, 'sub': 2', 'n, 'Ais Acc, Aib, Arg, Asn, Asp, Dab, Dap, Gln, Lys, Orn, or HN—CH((CH)—N(RR))—C(O);'}{'sup': 9', '1', '2', '3', '4', '5, 'Ais Aib, Acc, Apc, 2-Fua, 2-Pal, 3-Pal, 4-Pal, Taz, 2-Thi, 3-Thi, or (X,X,X,X,X)Phe; and'}{'sup': '10', 'Ais Acc, Aib, Asn, Asp, or Glu.'}40. The method of claim 38 , wherein the compound of formula (I) is selected from:{'sup': '3', 'sub': '2', '(Dap(octanesulfonyl))hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, A6c)hGhrelin(1-28)-NH;'}{'sup': '5', 'sub': '2', '(A6c)hGhrelin(1-28)-NH;'}{'sup': '2,6', 'sub': '2', '(Aib)hGhrelin(1-28)-NH;'}{'sup': 2', '12, 'sub': '2', '(Aib, A5c)hGhrelin(1-28)-NH;'}{'sup': 2', '12', '15, 'sub': '2', '(Aib, A5c, Orn)hGhrelin(1-28)-NH;'}{'sup': 2', '12', '16, 'sub': '2', '(Aib, A5c, Apc)hGhrelin(1-28)-NH;'}{'sup': 2', '6, 'sub': '2', '(Aib, Act)hGhrelin(1-28)-NH;'}{'sup': 2', '9, 'sub': '2', '(Aib, 3-Pal)hGhrelin(1-28)-NH;'}{'sup': 2', '7, 'sub': '2', '(Aib, Dmt)hGhrelin(1-28)-NH;'}{'sup': 2', '7, 'sub': '2', '(Aib, Thz)hGhrelin(1-28)-NH; and'}{'sup': '2', 'sub': '2', '(A5c)hGhrelin(1-28)-NH, or a pharmaceutically acceptable salt thereof.'}41. The method of claim 38 , wherein the compound of formula (I) is selected from:{'sup': '2', 'sub': '2', '(Act)hGhrelin(1-28)- ...

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Номер записи: 68
04-12-2014 дата публикации

LINK AGGREGATION BASED ON VIRTUAL INTERFACES OF VLANS

Номер: US20140355445A1
Автор: Dong Xiang Hui, Guo Yuhong, SUN Yun, Zhu Zheng Dong
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A method of managing data transmission based on virtual local area networks includes obtaining a first VLAN property of a first physical interface and a second VLAN property of a second physical interface; in response to determining the first VLAN property and the second VLAN property are at least partially identical, obtaining a first virtual interface corresponding to the first physical interface and a second virtual interface corresponding to the second physical interface; and mapping the first physical interface and the second physical interface to an identical data channel via the first virtual interface and the second virtual interface, wherein the first physical interface and the second physical interface are located in a same processing device. 1. A method of managing data transmission based on virtual local area networks , comprising:obtaining a first VLAN property of a first physical interface and a second VLAN property of a second physical interface;in response to determining that the first VLAN property and the second VLAN property are at least partially identical, obtaining a first virtual interface corresponding to the first physical interface and a second virtual interface corresponding to the second physical interface; andmapping the first physical interface and the second physical interface to an identical data channel via the first virtual interface and the second virtual interface,wherein the first physical interface and the second physical interface are located in a same processing device.2. The method according to claim 1 , wherein the first VLAN property and the second VLAN property at least describe at least one virtual local area network supported by the first physical interface and the second physical interface claim 1 , respectively.3. The method according to claim 1 , wherein obtaining a first VLAN property of a first physical interface and a second VLAN property of a second physical interface comprises:reading from a configuration file in ...

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Номер записи: 69
15-10-2015 дата публикации

Somatostatin-Dopamine Chimeric Analogs

Номер: US20150290330A1
Автор: Dong Zheng Xin, KIM Sun Hyuk, SHEN Yeelana
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions. 1. A compound comprising:at least one moiety which binds to one or more dopamine receptor subtypes; and {'br': None, 'sup': 1', '5', '9, 'A-cyclo(DLys-Arg-Phe-A-DTrp-Lys-Thr-A)\u2003\u2003(I)'}, 'a somatostatin analog moiety according to Formula I (SEQ ID NO:58) [{'sup': '1', 'Ais DTyr, Tyr, DLys, Lys, or absent;'}, {'sup': '5', 'Ais Phe, 2Pal, 3Pal, or 4Pal; and'}, {'sup': '9', 'Ais Phe, 2FPhe, 3FPhe, 4FPhe, 3,4FPhe, 3,5FPhe, 2,3,4,5,6FPhe, or Tyr;'}], 'whereinwherein said at least one moiety which binds to one or more dopamine receptor subtypes is, independently for each occurrence, attached to the N-terminal amine group, or an internal amine or hydroxyl group, of said somatostatin analog moiety according to Formula I;or a pharmaceutically acceptable salt thereof.2. A compound comprising:at least one moiety which binds to one or more dopamine receptor subtypes; and {'br': None, 'sup': 1', '5', '9, 'A-B-cyclo(DLys-Arg-Phe-A-DTrp-Lys-Thr-A)\u2003\u2003(II)'}, 'a somatostatin analog moiety according to Formula II (SEQ ID NO:59) A is DTyr, Tyr, DLys, Lys, or absent;', 'B is a pseudopeptide bond;', {'sup': '5', 'Ais Phe, 2Pal, 3Pal, or 4Pal; and'}, {'sup': '9', 'Ais Phe, 2FPhe, 3FPhe, 4FPhe, 3,4FPhe, 3,5FPhe, 2,3,4,5,6FPhe, or Tyr;'}], 'whereinwherein said at least one moiety which binds to one or more dopamine receptor subtypes is, independently for each occurrence, attached to the N-terminal amine group, or an internal amine or hydroxyl group, of said somatostatin analog moiety according to Formula II;or a pharmaceutically acceptable salt thereof.3. The compound according to claim 2 , wherein said pseudopeptide bond is psi(CHNR) claim 2 , wherein R is H claim 2 , (C)alkyl claim 2 , substituted (C)alkyl claim 2 , (C)heteroalkyl ...

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Номер записи: 70
12-09-2019 дата публикации

Dynamic Bandwidth Allocation for Wireless Mesh Networks

Номер: US20190280934A1
Автор: Efron Adam Joshua, Gopala Praveen Kumar, Nemavat Pradeep Jugraj, ZHENG Dong
Принадлежит:

Apparatuses, methods, and systems for dynamic bandwidth allocation are disclosed. One method includes identifying, by a first distribution node of a wireless mesh network, a communication link with a second distribution node of the wireless mesh network, generating, by the first distribution node, a proposed bandwidth allocation schedule for wireless communication of information between the first distribution node and the second distribution node, wherein the second distribution node receives the proposed bandwidth allocation schedule, and wherein the second distribution node adjusts the proposed bandwidth allocation schedule. The method further includes receiving, by the first distribution node, the adjusted proposed bandwidth allocation schedule from the second distribution node, and communicating, by the first distribution node, information with the second distribution node according to the adjusted proposed bandwidth allocation schedule. 1. A method , comprising:identifying, by a first distribution node of a wireless mesh network, a communication link with a second distribution node of the wireless mesh network;generating, by the first distribution node, a proposed bandwidth allocation schedule for wireless communication of information between the first distribution node and the second distribution node;wherein the second distribution node receives the proposed bandwidth allocation schedule, and wherein the second distribution node adjusts the proposed bandwidth allocation schedule;receiving, by the first distribution node, the adjusted proposed bandwidth allocation schedule from the second distribution node; andcommunicating, by the first distribution node, information with the second distribution node according to the adjusted proposed bandwidth allocation schedule.2. The method of claim 1 , further comprising:allocating, by the first distribution node, at least a portion of available bandwidth allocations of the adjusted proposed bandwidth allocation schedule ...

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Номер записи: 71
12-10-2017 дата публикации

Electronic Device With Obstruction-Sensing Color Ambient Light Sensor

Номер: US20170294173A1
Автор: Bommu Venkata Siva Sunil Kumar Reddy, Isikman Serhan O., Jia Zhang, Land Brian R., Sun Tianbo, ZHENG Dong
Принадлежит:

An electronic device may have a housing in which a display is mounted. The display may have an active area in which images are displayed by an array of pixels and an inactive area that is free of pixels. A color ambient light sensor may make color and luminance measurements on ambient light received through an ambient light sensor window in the inactive area of the display or elsewhere in the electronic device. The color ambient light sensor may have color ambient light sensor elements of different colors. The ambient light sensor elements may extend in a row along an edge of the display or may have other configurations. Analog-to-digital converter circuitry and switching circuitry may gather color ambient light sensor measurements and measurements indicative of whether or not the color ambient light sensor has been obscured by an external object from the light sensor elements. 1. Color ambient light sensor circuitry , comprising:a color ambient light sensor having light sensor elements of at least two different colors;analog-to-digital converter circuits that digitize signals from the light sensor elements; and route signals to the analog-to-digital converter circuits from respective first sets of the light sensor elements when the switching circuitry is operated in an ambient light color measurement mode;', 'route signals to the analog-to-digital converter circuits from respective second sets of the light sensor elements when the switching circuitry is operated in a sensor illumination non-uniformity detection mode., 'switching circuitry coupled between the light sensor elements and the analog-to-digital converter circuits, wherein the switching circuitry is selectively configured to2. The color ambient light sensor circuitry defined in wherein the light sensor elements are arranged in a row in the color ambient light sensor.3. The color ambient light sensor circuitry defined in wherein the light sensor elements include light sensor elements of at least four ...

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Номер записи: 72
11-10-2018 дата публикации

SYSTEMS AND METHODS FOR IDENTIFYING CERTIFICATES

Номер: US20180294978A1
Автор: Camp L. Jean, DONG Zheng
Принадлежит: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

A learning certificate authentication system comprising a certificate downloader configured to obtain a certificate, a feature extractor in communication with the certificate downloader that is configured to (i) parse information associated with the certificate and a pattern of use into actionable features and (ii) calculate a value associated with at least one of the actionable features, a classification extractor configured to process the vector with a learning model based on the pattern of use information, a processor, and a non-transitory memory having instructions that, in response to an execution by the processor, cause the processor to calculate a probability of authenticity based on the processed vector are disclosed. Methods of authenticating certificates are also disclosed. 1. A learning certificate authentication system comprising:a certificate downloader configured to obtain a certificate; (i) parse information associated with the certificate and a pattern of use into actionable features; and', '(ii) calculate a value associated with at least one of the actionable features;, 'a feature extractor in communication with the certificate downloader that is configured to'}a classification extractor configured to process a vector with a learning model based on the pattern of use information;a processor; anda non-transitory memory having instructions that, in response to an execution by the processor, cause the processor to calculate a probability of authenticity based on the processed vector.2. The system of claim 1 , wherein the learning model comprises at least one of: Random Forrest claim 1 , K-Nearest Neighbors claim 1 , C4.5 claim 1 , a decision table claim 1 , a Navie Bayes Tree claim 1 , and Simple Logistic.3. The system of claim 1 , wherein the instructions on the non-transitory memory comprise at least one of: a Random Forrest algorithm and an average probability.4. The system of claim 1 , wherein the system is configured to determine the authenticity ...

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Номер записи: 73
20-10-2016 дата публикации

Distributed Light Sensors for Ambient Light Detection

Номер: US20160307542A1
Автор: Land Brian R., ZHENG Dong
Принадлежит:

An electronic device may have a display with a brightness that is adjusted based on ambient light data from multiple ambient light sensors. Sensors that are shadowed can be ignored. A touch sensor array in the display may have electrodes that overlap ambient light sensors. When a touch sensor signal indicates that an external object is covering one of the ambient light sensors, data from that ambient light sensor can be discarded. The ambient light sensors may include a primary ambient light sensor such as a human-eye-response ambient light sensor and may include an array of secondary ambient light sensors such as non-human-eye-response sensors. The secondary ambient light sensors may be formed on a display layer such as a thin-film-transistor layer and may be formed from thin-film materials. An algorithm may be used to dynamically calibrate non-human-eye-response ambient light sensors to the human-eye-response ambient light sensor. 1. (canceled)2. A display having an active; area and an inactive area , the display comprising:a display cover layer;an opaque masking layer formed on an inner surface of the display cover layer in the inactive area;an array of pixels that emit light through the display cover layer in. the active area; anda touch sensor having a first portion with touch sensor electrodes in the active area of the display and a second portion with at least one additional touch sensor electrode in the inactive area of the display, wherein the second portion of the touch sensor extends under the opaque masking layer.3. The display defined in wherein the: touch sensor electrodes and the at least one additional touch sensor electrode comprise capacitive touch sensor electrodes.4. The display defined in wherein the opaque masking layer has an opening in the inactive area to accommodate an ambient light sensor and wherein the touch sensor detects touches in the inactive area surrounding the ambient light sensor.5. The display defined in wherein the touch sensor ...

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Номер записи: 74
29-10-2015 дата публикации

TRANSFERRING DATA IN A GATEWAY

Номер: US20150312137A1
Автор: Li Yuan, Tang Gang, Zhu Zheng Dong
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

The present invention discloses a gateway and its method of transferring data, the gateway being connected to a network by a SIMM-node. In response to a request to establish multi-MAC address routing information of a SIMM-node, multiple MAC addresses corresponding to an IP address of the SIMM-node are obtained. The multi-MAC address routing information of the SIMM-node is established at least according to the obtained multiple MAC addresses corresponding to the IP address of the SIMM-node. In response to receiving a data message sent to the IP address of the SIMM-node, the data message is routed by using the established multi-MAC address routing information of the SIMM-node. 1. A method of transferring data by a gateway , the gateway being connected to a network with a SIMM-node , the method comprising: obtaining multiple MAC addresses corresponding to an IP address of the SIMM-node; and', 'establishing the multi-MAC address routing information of the SIMM-node at least according to the obtained multiple MAC addresses corresponding to the IP address of the SIMM-node; and, 'in response to a request to establish multi-MAC address routing information of a SIMM-nodein response to having received a data message sent to the IP address of the SIMM-node, routing the data message by using the established multi-MAC address routing information of the SIMM-node.2. The method according to claim 1 , wherein the multi-MAC address routing information at least comprises information in each of a route table claim 1 , an ARP table claim 1 , and a NEXT_HOP table to which a next-hop pointer in the route table points claim 1 , and wherein the establishing the multi-MAC address routing information of the SIMM-node comprises:adding to the ARP table corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node;adding to the NEXT_HOP table the corresponding relationships of the IP address with the multiple MAC addresses of the SIMM-node; andestablishing in ...

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Номер записи: 75
10-09-2020 дата публикации

SYSTEMS AND METHODS FOR BEAMFORMING

Номер: US20200287653A1
Автор: FAN Yuting, Lu Gang, Qu Qi, ZHENG Dong
Принадлежит:

Systems and methods for beamforming include a device including at least one of a head wearable display (HWD) or a console. The device establishes a first connection between an active HWD radio-frequency integrated circuit (RFIC) and an active console RFIC. The device compares a modulation and coding scheme (MCS) of the first connection to an MCS threshold. The device performs MCS measurements for a second connection of at least one of an idle HWD RFIC or an idle console RFIC, while the first connection is maintained, in response to the MCS not satisfying the MCS threshold. The device compares the MCS measurements of the second connection to the MCS threshold. The device switches to the second connection when at least one of the one or more MCS measurements satisfies the MCS threshold and/or above the MCS of the first connection. 1. A method , comprising:establishing, by a device comprising at least one of a head wearable display (HWD) or a console, a first connection between an active HWD radio-frequency integrated circuit (RFIC) and an active console RFIC;comparing, by the device, a modulation and coding scheme (MCS) of the first connection to an MCS threshold;performing, by the device in response to the measured MCS not satisfying the MCS threshold, one or more MCS measurements for a second connection of at least one of an idle HWD RFIC or an idle console RFIC, while the first connection is maintained;comparing, by the device, the one or more MCS measurements of the second connection to the MCS threshold; andswitching, by the device, to the second connection when at least one of the one or more MCS measurements exceeds at least one of: the MCS threshold or the MCS of the first connection.2. The method of claim 1 , comprising switching claim 1 , by the device claim 1 , to the second connection when the at least one MCS measurement of the second connection exceeds a hysteresis component above at least one of: the MCS threshold or the MCS of the first connection.3. ...

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Номер записи: 76
10-09-2020 дата публикации

SECONDARY LINK FOR AR/VR APPLICATIONS

Номер: US20200288360A1
Автор: Abbott William Louis, FAN Yuting, Lu Gang, Qu Qi, ZHENG Dong
Принадлежит:

Disclosed herein a system, a method and a device for selecting between a primary link and a secondary link for AR/VR applications. A console can provide a VR/AR session to a user through a head wearable display. The console can determine that a first measurement of a primary link between the console and a head wearable display is less than a first threshold. The first measurement can include a quality metric of the primary link. The console can activate a secondary link between the console and the head wearable display. The console can determine whether a second measurement of the primary link between the console and the head wearable display is less than a second threshold. The console can transition when the second measurement is less than the second threshold, traffic on the primary link to the activated secondary link. 1. A method comprising:determining, by a console, that a first measurement of a primary link between the console and a head wearable display is less than a first threshold, the first measurement corresponding to a quality metric of the primary link;activating, by the console responsive to the first measurement being less than the first threshold, a secondary link between the console and the head wearable display;determining, by a console, whether a second measurement of the primary link between the console and the head wearable display is less than a second threshold, wherein the second threshold is less than the first threshold; andtransitioning, by the console when the second measurement is less than the second threshold, traffic on the primary link to the activated secondary link.2. The method of claim 1 , wherein the quality metric comprises a signal to noise ratio of the primary link.3. The method of claim 1 , further comprising:maintaining, by the console, the traffic on the primary link when the second measurement is greater than the second threshold.4. The method of claim 1 , further comprising:performing, by the console responsive to the ...

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Номер записи: 77
10-09-2020 дата публикации

SYSTEMS AND METHODS FOR DYNAMIC SCHEDULING

Номер: US20200288492A1
Автор: FAN Yuting, Lu Gang, Qu Qi, ZHENG Dong
Принадлежит:

Disclosed herein a system, a method and a device for dynamic scheduling between a head wearable display and a console is provided. The head wearable display can initiate, at a first time instance, a first downlink transmission to the console. The head wearable display can dynamically indicate, to the console, an end of the first downlink transmission, at a second time instance when transfer of data of the first downlink transmission is complete. The head wearable display can dynamically cause, relative to the second time instance, the console to begin an uplink transmission. The head wearable display can receive an indication to dynamically start a second downlink transmission, at a third time instance when transfer of data of the uplink transmission is complete. 1. A method comprising:initiating, by a head wearable display at a first time instance, a first downlink transmission to a console;dynamically indicating, by the head wearable display to the console, an end of the first downlink transmission, at a second time instance when transfer of data of the first downlink transmission is complete;dynamically causing, by the head wearable display, relative to the second time instance, the console to begin an uplink transmission; andreceiving, by the head wearable display, an indication to dynamically start a second downlink transmission, at a third time instance when transfer of data of the uplink transmission is complete.2. The method of claim 1 , further comprising:estimating an expected duration for a data transmission interval between the head wearable display and the console according to an amount of data to be transferred and properties of a channel between the head wearable display and the console, the data transmission interval including the first downlink transmission and the uplink transmission.3. The method of claim 1 , further comprising:estimating, by the head wearable display, a time period for the first downlink transmission.4. The method of claim 3 , ...

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Номер записи: 78
26-10-2017 дата публикации

METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE

Номер: US20170304403A1
Автор: Culler Michael DeWitt, Datta Rakesh, Dong Zheng Xin, Taylor John E.
Принадлежит: IPSEN PHARMA S.A.S.

The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin. 2. A method of limiting myocardial damage during an acute myocardial infarction in a subject in need thereof according to wherein said analogue or said prodrug thereof is H-Inp-D-Bal-D-Trp-Phe-Apc-NH(SEQ ID: 2) or a pharmaceutically acceptable salt thereof.3. The method of claim 1 , wherein said peptidyl analogue of ghrelin or said prodrug thereof inhibits C-reactive protein.4. The method of wherein said C-reactive protein is synthesized in response to inflammation. This application is a divisional application of U.S. Ser. No. 14/997,678, filed Jan. 18, 2016, which is a is a continuation application of U.S. Ser. No. 14/524,088, filed Oct. 27, 2014, which is a continuation application of U.S. Ser. No. 12/672,681, filed Feb. 8, 2010, which is is a United States national stage filing under 35 U.S.C. §371 of international (PCT) application No. PCT/US2008/009494, filed Aug. 7, 2008, and designating the US, which claims priority to US provisional application No. 60/963,951, filed Aug. 8, 2007, each of which is hereby incorporated by reference in its entirety.The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS—Web, and is hereby incorporated by reference in its entirety. The ASCII copy, is named, “168P_PCT2_US—B_sequence_listing.txt”, created on Jan. 18, 2016, and has the file size of 262,000 bytes.The present invention is directed to methods for attenuating inflammation in a patient which comprises administering peptidyl analogues that possess agonistic ghrelin activity, a prodrug thereof, or a pharmaceutically acceptable salt of said analogues or prodrug.Inflammation is a complex of sequential ...

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Номер записи: 79
27-10-2016 дата публикации

Growth Hormone Releasing Peptides

Номер: US20160311855A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: 2. A compound according to claim 1 , wherein said compound is according to the formula:H-Inp-D-Bal-D-Trp-Phe-Apc-NH2;H-Inp-D-1Nal-D-Trp-3Pal-Lys-NH2;H-Inp-D-2Nal-D-Trp-4Pal-Lys-NH2;H-Inp-D-2Nal-D-Trp-Orn-Lys-NH2;H-Inp-D-Bip-D-Trp-Phe-Lys-NH2;H-Inp-D-2Nal-D-Trp-Thr(Bzl)-Lys-NH2;H-Inp-D-2Nal-D-Trp-Pff-Lys-NH2;H-Inp-D-2Nal-D-Trp-2Thi-Lys-NH2;H-Inp-D-2Nal-D-Trp-Taz-Lys-NH2;H-Inp-D-Dip-D-Trp-Phe-Lys-NH2;H-Inp-D-Bpa-D-Trp-Phe-Lys-NH2;H-Inp-D-2Nal-D-Trp-3Pal-Lys-NH2;H-Inp-D-Bal-D-Trp-2Thi-Lys-NH2;H-Inp-D-Bal-D-Trp-Phe-Lys-NH2;H-Inp-D-1Nal-D-Trp-2Thi-Lys-NH2;H-Inp-D-2Nal-D-Trp-Phe-Apc-NH2;H-Inp-D-1Nal-D-Trp-Phe-Apc-NH2;H-Inp-D-1Nal-D-Trp-Taz-Lys-NH2;H-Inp-D-Bal-D-Trp-Taz-Lys-NH2;H-Inp-D-1Nal-D-Trp-Taz-Apc-NH2;H-Inp-D-Bal-D-Trp-Taz-Apc-NH2;H-Inp-D-1Nal-D-Bal-2Fua-Lys-NH2;H-Inp-D-1Nal-D-Bal-2Thi-Lys-NH2;H-Inp-D-1Nal-D-Bal-3Thi-Lys-NH2;H-Inp-D-1Nal-D-Bal-Pff-Lys-NH2;H-Inp-D-1Nal-D-Bal-Phe-Lys-NH2;H-Inp-D-1Nal-D-Bal-Taz-Lys-NH2;H-Inp-D-1Nal-D-Trp-2Fua-Apc-NH2;H-Inp-D-1Nal-D-Trp-2Fua-Lys-NH2;H-Inp-D-1Nal-D-Trp-3Thi-Apc-NH2;H-Inp-D-1Nal-D-Trp-3Thi-Lys-NH2;H-Inp-D-1Nal-D-Trp-Pff-Apc-NH2;H-Inp-D-1Nal-D-Trp-Pff-Lys-NH2;H-Inp-D-2Nal-D-Trp-2Fua-Apc-NH2;H-Inp-D-2Nal-D-Trp-2Thi-Apc-NH2;H-Inp-D-2Nal-D-Trp-3Thi-Apc-NH2;H-Inp-D-2Nal-D-Trp-3Thi-Lys-NH2;H-Inp-D-2Nal-D-Trp-Pff-Apc-NH2;H-Inp-D-2Nal-D-Trp-Taz-Apc-NH2;H-Inp-D-Bal-D-Bal-2Fua-Lys-NH2;H-Inp-D-Bal-D-Bal-2Thi-Lys-NH2;H-Inp-D-Bal-D-Bal-3Thi-Lys-NH2;H-Inp-D-Bal-D-Bal-Pff-Lys-NH2;H-Inp-D-Bal-D-Bal-Phe-Lys-NH2;H-Inp-D-Bal-D-Bal-Taz-Lys-NH2;H-Inp-D-Bal-D-Trp-2Fua-Apc-NH2;H-Inp-D-Bal-D-Trp-2Fua-Lys-NH2;H-Inp-D-Bal-D-Trp-3Thi-Apc-NH2;H-Inp-D-Bal-D-Trp-3Thi-Lys-NH2;H-Inp-D-Bal-D-Trp-Pff-Apc-NH2;H-Inp-D-Bal-D-Trp-Pff-Lys-NH2;H-Inp-D-Bip-D-Bal-2Fua-Lys-NH2;H-Inp-D-Bip-D-Bal-2Thi-Lys-NH2;H-Inp-D-Bip-D-Bal-3Thi-Lys-NH2;H-Inp-D-Bip-D-Bal-Pff-Lys-NH2;H-Inp-D-Bip-D-Bal-Taz-Lys-NH2;H-Inp-D-Bip-D-Trp-2Fua-Lys-NH2;H-Inp-D-Bip-D-Trp- ...

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Номер записи: 80
26-10-2017 дата публикации

MICROSCOPE AND METHOD FOR OBTAINING A HIGH DYNAMIC RANGE SYNTHESIZED IMAGE OF AN OBJECT

Номер: US20170307869A1
Автор: SCHMID Urs, ZENG Zheng-Dong, ZOU Qing-Song
Принадлежит:

A microscope () for obtaining a high dynamic range synthesized image () of an object () from a plurality of low dynamic range input images () comprises a controller (), an incoherent light source () for illuminating the object () at different light intensity levels, and a recording device () for recording the plurality of low dynamic range input images (), wherein each of the low dynamic range input images () is recorded at a different light intensity level. The controller () is configured to control the recording device () such that during recording of the series of the low dynamic range images the recording parameters for obtaining the plurality of low dynamic range input images () are kept constant. 11021121910. A microscope () for obtaining a high dynamic range synthesized image () of an object () from a plurality of low dynamic range input images () , the microscope () comprising{'b': 16', '12, 'an incoherent light source () for illuminating the object () at different light intensity levels,'}{'b': 18', '28', '26', '19', '19, 'a recording device () comprising an optical imaging system () having an optical aperture and an image sensor () for recording the plurality of low dynamic range input images (), wherein each of the low dynamic range input images () is recorded at a different light intensity level, and'}{'b': 14', '18', '16', '19, 'a controller () which is configured to provide control signals to control the recording device () and the incoherent light source () such that the plurality of low dynamic range input images () at different light intensity levels is captured while at least one of a plurality of recording parameters is kept constant.'}210141819. The microscope () according to claim 1 , characterized in that the controller () is configured to control the recording device () while a frame rate during capturing the plurality of low dynamic range input images () is kept constant.310282619. The microscope () according to claim 1 , characterized in ...

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Номер записи: 81
05-11-2015 дата публикации

Femtocell Fingerprinting

Номер: US20150319679A1
Автор: Budhwani Sultan, Diwan Aniruddha Subhash, Gupta Sudip Alexei, LIU Yuan, Majumdar Soma, Mhetre Vikram Shantveer, Mohajer Mojan, Nargundkar Sagar, Pandit Abhishek, PRAKASAM Sridhar, ROLLINGER Odile, Sarthavalli Ramesh Sandeep, ZHENG Dong
Принадлежит:

User equipment (UE) includes an architecture for handling femtocell fingerprints. The architecture may, as examples, maintain the validity and reliability of fingerprints and coordinate enhancement to existing fingerprints. The architecture also supports fingerprint creation, updating, and deletion. 1. A method comprising:establishing a central fingerprint database operable to store fingerprints for proximity detection, the fingerprints characterizing femtocells; creating the fingerprints, and storing, for the fingerprints, fingerprint components that characterize the femtocells;', 'selectively updating the fingerprint components; and', 'deleting selected fingerprints among the fingerprints; and, 'executing a fingerprint manager in communication with the fingerprint database for obtaining environmental measurements;', 'analyzing the fingerprints to find a matching fingerprint with respect to the environmental measurements; and', 'initiating a cell search for a specific femtocell that corresponds to the matching fingerprint., 'executing a proximity detector in communication with the fingerprint database, and, with the proximity detector2. The method of claim 1 , further comprising:determining a particular femtocell for enhanced fingerprinting, and in response:creating multiple fingerprints in the central fingerprint database for that particular femtocell.3. The method of claim 2 , where determining comprises:determining the particular femtocell responsive to frequency of selection of that particular femtocell.4. The method of claim 2 , where determining comprises:determining the particular femtocell responsive to recency of selection of that particular femtocell.5. The method of claim 1 , further comprising:obtaining at least some of the fingerprint components from radio resource control measurements of neighboring macrocells.6. The method of claim 1 , further comprising:obtaining at least some of the fingerprint components from positioning system measurements of ...

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Номер записи: 82
25-10-2018 дата публикации

Melanocortin Receptor Ligands

Номер: US20180305406A1
Автор: Dong Zheng Xin, MOREAU Jacques-Pierre
Принадлежит: IPSEN PHARMA S.A.S.

The present invention is directed to compounds according to formula, 19. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of to , or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier or diluent.20. A pharmaceutical composition according to claim 19 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof.21. A pharmaceutical composition according to claim 20 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof with a functional activity characterized by an ECat least 15-fold more selective for the human melanocortin 4 receptor than for the human melanocortin-1 receptor claim 20 , the human melanocortin-3 receptor and the human melanocortin-5 receptor.22. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 17-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.23. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 90-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.24. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 200-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.25. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 3000-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.26. A pharmaceutical composition according to useful ...

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Номер записи: 83
16-11-2017 дата публикации

Color Ambient Light Sensor Circuitry For Electronic Devices

Номер: US20170328767A1
Автор: ZHENG Dong
Принадлежит:

An electronic device may be provided with a display mounted in a housing. The display may have an array of pixels that form an active area and may have an inactive area that runs along an edge of the active area. A color ambient light sensor may gather ambient light measurements through a window in an opaque masking layer in the inactive area. The color ambient light sensor may have photodiodes with different spectral sensitivities and may have a dark current photodiode that is insensitive to light. A set of analog-to-digital converters may be used to digitize photodiode signals from the photodiodes. A switch array may be used to distribute signals from the photodiodes to each of the analog-to-digital converters. This allows the output of each photodiode to be averaged over multiple analog-to-digital converters to remove any impact of variations in performance between converters. 1. An electronic device , comprising:a housing;control circuitry in the housing;a color ambient light sensor in the housing having photodiodes of different colors;a plurality of analog-to-digital converters; andan array of switches that is operable to route photodiode signals from each of the photodiodes to each of the analog-to-digital converters, wherein the control circuitry is configured to place the array of switches in a plurality of different switch array configurations and wherein in each of the different switch array configurations the photodiode signal from each of the photodiodes is digitized by a different one of the analog-to-digital converters.2. The electronic device defined in wherein the control circuitry is configured to average the digitized photodiode signals from each of the photodiodes of different colors to produce averaged photodiode signals for each of the different colors.3. The electronic device defined in further comprising a display in the housing claim 2 , wherein the control circuitry is configured to use the averaged photodiode signals for each of the ...

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Номер записи: 84
17-11-2016 дата публикации

Probabilistic Classifiers for Certificates

Номер: US20160337133A1
Автор: DONG Zheng, Kane Kevin, Penta Anthony P., Yiu Kelvin S.
Принадлежит:

Classifiers may be used to analyze a valid certificate received from an unverified entity in an attempt to establish a secure connection with the unverified entity. The classifiers may determine a probability that the certificate is being used improperly by an unauthorized third party. An action may be taken based on the probability, such as allowing the unverified entity to establish a secure connection, blocking the unverified entity from establishing a secure connection, etc. The classifiers may be trained by employing machine learning techniques on a collection of valid, authorized certificates. Additionally, or alternatively, received certificates may be sampled for further analysis based on the probability and/or predefined sampling percentages. 1. A computing device comprising:one or more processors;a display communicatively coupled to the one or more processors and configured to display content;memory communicatively coupled to the one or more processors; receive, from an unverified entity, a request to perform an operation with the unverified entity, the operation relating to communication with the unverified entity over a secure channel; and', 'receive, from the unverified entity, a certificate associated with the unverified entity;, 'a communication module stored in the memory and executable by the one or more processors toa selection module stored in the memory and executable by the one or more processors to determine one or more classifiers to employ based at least in part on one or more characteristics of the certificate; and determine that the certificate is valid and determine a probability that the certificate is being used improperly;', 'cause the certificate to be stored in the memory based at least in part on a sampling percentage associated with the probability that the valid certificate is being used improperly;', 'determine an action to be performed based at least in part on the probability that the certificate is being used improperly; and', ...

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Номер записи: 85
17-10-2019 дата публикации

Color Ambient Light Sensor With Tunable Filter

Номер: US20190317258A1
Автор: Cai Xingxing, Holenarsipur Prashanth S., Isikman Serhan O., Lyngnes Ove, Sun Tianbo, XU Tingjun, Zhao Xianwei, ZHENG Dong
Принадлежит:

An electronic device may be provided with a color ambient light sensor. The color ambient light sensor may be used to measure an ambient light spectrum over a wavelength range of interest. Control circuitry in the electronic device can take actions based on the measured ambient light spectrum such as adjusting the brightness and color cast of content on a display. A display may have a display cover layer. The color ambient light sensor can be mounted under the display cover layer and may receive ambient light through the display cover layer. The color ambient light sensor may have a tunable wavelength filter such as an electrically adjustable Fabry-Perot resonator. A light collimator may be interposed between the display cover layer and the Fabry-Perot resonator to collimate ambient light that is passed to the Fabry-Perot resonator. A light detector measures the light passing through the Fabry-Perot resonator. 1. An electronic device , comprising:a housing;a display in the housing;a color ambient light sensor having a tunable filter and having a photodiode that is configured to receive ambient light passing through the tunable filter; and measure an ambient light spectrum for the ambient light by measuring signals from the photodiode while adjusting the tunable filter; and', 'adjust content on the display based on the measured ambient light spectrum., 'control circuitry in the housing that is configured to2. The electronic device defined in wherein the tunable filter is an electrically adjustable Fabry-Perot resonator with an adjustable passband and wherein the control circuitry is configured to measure the ambient light spectrum by adjusting the Fabry-Perot resonator to sweep the passband over a wavelength range between a first wavelength and a second wavelength.3. The electronic device defined in wherein the control circuitry includes an analog-to-digital converter configured to digitize signals from the photodiode.4. The electronic device defined in wherein the ...

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Номер записи: 86
30-11-2017 дата публикации

Ambient Light Sensors with Auto Gain Switching Capabilities

Номер: US20170344097A1
Автор: Bommu Venkata Siva Sunil Kumar Reddy, Land Brian R., ZHENG Dong
Принадлежит:

An ambient light sensor that is operable in high gain mode and low gain mode is provided. The high gain mode may help provide satisfactory sensitivity at low light levels but may generate saturated output levels in bright ambient lighting conditions. Low gain mode may therefore be switched into use when bright ambient lighting conditions are detected. The ambient light sensor may be placed in high gain mode by default. An auto-gain switch controller may detect whether the ambient light reading is saturated during a given period of time. In response to determining that the ambient light reading is saturated for a programmable number of consecutive time periods, the auto-gain switch controller may reset and switch the ambient light sensor to the low gain mode. The gain state may optionally be embedded into the ambient light sensor output. 1. An electronic device comprising:a housing;an ambient light sensor in the housing that generates an ambient light sensor output and includes an analog-to-digital converter operable in a plurality of gain states; andcontrol circuitry in the housing that measures ambient light intensity using the ambient light sensor output and that switches the analog-to-digital converter from a first gain state in the plurality of gain states to a second gain state in the plurality of gain states in response to the ambient light sensor output.2. The electronic device defined in claim 1 , wherein the control circuitry selectively enables the ambient light sensor in an auto gain switching mode that allows the ambient light sensor to operate in the plurality of gain states.3. The electronic device defined in claim 1 , wherein the ambient light sensor comprises:an auto gain switching (AGS) control logic that places the ambient light sensor in one of the plurality of gain states.4. The electronic device defined in claim 3 , wherein the auto gain switching control logic includes a saturation detection mechanism that detects when the ambient light sensor ...

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Номер записи: 87
29-10-2020 дата публикации

Electronic Devices With Ambient Light Sensors and Emissive Displays

Номер: US20200341512A1
Автор: Aflatooni Koorosh, Dodson Christopher M., Shao Guocheng, Vampola Kenneth J., ZHENG Dong
Принадлежит:

An electronic device may have a display with an array of pixels that display images for a user. The electronic device may have an ambient light sensor for gathering ambient light information. A subset of the pixels in the array of pixels may overlap the ambient light sensor so that ambient light passing through the subset of pixels may be measured. Each pixel may have an emission enable transistor coupled in series with a light-emitting diode. Control circuitry in the electronic device may disable the subset of pixels to reduce stray light during ambient light measurements while enabling remaining pixels in the array of pixels to display an image. Ambient light sensor circuitry may gather ambient light sensor measurements over one or more periods by using transfer transistors to transfer change from the photodetectors to charge storage capacitors formed from floating diffusions in a common substrate. 1. An electronic device , comprising:a housing;a display coupled to the housing that has an array of pixels with adjustable light emission levels; and photodetectors formed in a semiconductor substrate, wherein the photodetectors are configured to gather ambient light measurements on ambient light passing through a subset of the array of pixels overlapping the photodiodes;', 'storage capacitors formed in the semiconductor substrate; and', 'transistors that are each respectively formed in the semiconductor substrate between one of the photodiodes and one of the storage capacitors., 'ambient light measurement circuitry comprising2. The electronic device defined in wherein the ambient light measurement circuitry comprises analog-to-digital converter circuitry configured to receive signals from the storage capacitors.3. The electronic device defined in wherein the storage capacitors comprise floating diffusions in the semiconductor substrate.4. The electronic device defined in wherein the photodetectors are configured to gather color information on the ambient light.5. The ...

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Номер записи: 88
29-10-2020 дата публикации

Latency reduction for artificial reality

Номер: US20200344754A1
Автор: DONG Zheng, Gang Lu, Nicholas Daniel Trail, Qi Qu, William Louis ABBOTT
Принадлежит: Facebook Technologies LLC

Disclosed herein are related to a system and a method of remotely rendering artificial realty. In one approach, a console determines an expected transmission end time of a first session for wireless transmission of image data indicating an image of artificial reality to a head wearable display. In one approach, the console determines an expected process end time of generating additional data associated with the image of the artificial reality. In one approach, the console compares the expected transmission end time and the expected process end time. The console may transmit, to the head wearable display in the first session, the additional data together with the image data, in response to the expected process end time being less than the expected transmission end time.

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Номер записи: 89
22-12-2016 дата публикации

Melanocortin Receptor Ligands

Номер: US20160368962A1
Автор: Dong Zheng Xin, MOREAU Jacques-Pierre
Принадлежит:

The present invention is directed to compounds according to formula, 19. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier or diluent.20. A pharmaceutical composition according to claim 19 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof.21. A pharmaceutical composition according to claim 20 , wherein said compound is a selective melanocortin-4 receptor agonist or a pharmaceutically acceptable salt thereof with a functional activity characterized by an ECat least 15-fold more selective for the human melanocortin 4 receptor than for the human melanocortin-1 receptor claim 20 , the human melanocortin-3 receptor and the human melanocortin-5 receptor.22. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 17-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.23. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 90-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-3 receptor.24. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 200-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.25. A pharmaceutical composition according to claim 21 , wherein the functional activity of the melanocortin-4 receptor agonist is characterized by an ECat least 3000-fold more selective for the human melanocortin-4 receptor than for the human melanocortin-5 receptor.26. A method of eliciting an agonist or antagonist ...

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Номер записи: 90
05-11-2020 дата публикации

Composition and Methods for Stimulating Gastrointestinal Motility

Номер: US20200347110A1
Автор: Datta Rakesh, Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient. 1. A method of stimulating the motility of the gastrointestinal system in a patient , said method comprising administering a peptidyl analog of ghrelin , a prodrug thereof , or a pharmaceutically acceptable salt of said analog or said prodrug.2. The method of claim 1 , wherein said patient is experiencing postoperative ileus following gastrointestinal surgery.3. (canceled)710-. (canceled)11. A method of treating opioid-related bowel dysfunction in a patent claim 1 , said method comprising administering a peptidyl analog of ghrelin claim 1 , a prodrug thereof claim 1 , or a pharmaceutically acceptable salt of said analog or said prodrug.14. A method of wherein said peptidyl ghrelin analog comprises the following formula (III): {'br': None, 'sup': 2', '3', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27', '28', '1, '(RR)-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-A-R\u2003\u2003 (III)'}, 'formula (III) [{'sup': '1', 'Ais Gly, Aib, Ala, B-Ala, Acc or Gly(myristyl);'}, {'sup': '2', 'Ais Ser, Aib, Ala, Acc, Abu, Act, Ava, Thr or Val;'}, {'sup': 3', '4', '8', '9', '14', '10', '11', '6', '7', '5', '12', '13, 'sub': 2', '2', '2', 'n, 'Ais Ser, Ser(C(O)—R), Asp(O—R), Asp(NH—R), Cys(S—R), Dap(S(O)—R) Dab(S(O)—R), Glu(O—R), Glu(NH—R), Thr(C(O)—R) or HN—CH((CH)—N(RR))—C(O);'}, {'sup': 4', '1', '2', '3', '4', '5, 'Ais Phe, Acc, Aic, Cha, 2-Fua, 1-Nal, 2-Nal, 2-Pal, 3-Pal, 4-Pal, hPhe, (X,X,X,X,X)Phe, Taz, 2-Thi, 3-Thi, Trp or Tyr;'}, {'sup': '5', 'Ais Leu, Abu, Acc, Aib, Ala, Cha, Ile, hLeu, Nle, Nva, Phe, Tle or Val;'}, {'sup': '6', 'Ais Ser, Abu, Acc, Act, Aib ...

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Номер записи: 91
21-12-2017 дата публикации

Growth Hormone Releasing Peptides

Номер: US20170362275A1
Автор: Dong Zheng Xin
Принадлежит: IPSEN PHARMA S.A.S.

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: 17. A method of determining a compound's ability to bind to a GHS receptor , said method comprising the step of measuring the ability of a compound to affect binding of a compound according to formula (I) , Group 1 , Group 1A , Group 2 , Group 2A , Group 2B , Group 2B-1 , Group 2B-1a , Group 2B-1b , Group 2B-1c , Group 2B-1d , Group 2B-2 , Group 2B-2a , Group 2C , or Group 2C-1 to said receptor , to a fragment of said receptor , to a polypeptide comprising said fragment of said receptor , or to a derivative of said polypeptide.18. A method for achieving a beneficial affect in a subject in a subject in need thereof , said method comprising the step of administering to said subject an effective amount of a compound according to formula (I) , Group 1 , Group 1A , Group 2 , Group 2A , Group 2B , Group 2B-1 , Group 2B-1a , Group 2B-1b , Group 2B-1c , Group 2B-1d , Group 2B-2 , Group 2B-2a , Group 2C , or Group 2C-1 , or a pharmaceutically acceptable salt thereof , wherein said effective amount is effective for producing a beneficial effect in helping to treat (e.g. , cure or reduce the severity) or prevent (e.g. , reduce the likelihood of onset or severity) a disease or disorder.19. A method for stimulating growth hormone secretion in a subject in need of such stimulation , comprising the step of administering to a subject an effective amount of a ghrelin agonist according to formula (I) , Group 1 , Group 1A , Group 2 , Group 2A , Group 2B , Group 2B-1 , Group 2B-1a , Group 2B-1b , Group 2B-1c , Group 2B-1d , Group 2B-2 , Group 2B-2a , Group 2C , or Group 2C-1 , or a pharmaceutically acceptable salt thereof , wherein said effective amount is at least an amount sufficient to produce a detectable increase in growth hormone secretion and , preferably , is an amount sufficient to achieve a beneficial affect in a patient.20. A method according to wherein said ...

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Номер записи: 92
21-11-2019 дата публикации

HEALTH FILE ACCESS CONTROL SYSTEM AND METHOD IN ELECTRONIC MEDICAL CLOUD

Номер: US20190354714A1
Автор: GUO Rui, LAI Chengzhe, Zhang Yinghui, ZHAO Qinglan, ZHENG Dong
Принадлежит: XI'AN UNIVERSITY OF POSTS AND TELECOMMUNICATIONS

The present invention provides a health file access control system and method in an electronic medical cloud. The system comprises: a medical management center unit configured to generate a system public key and a system private key, and generate a private key for corresponding utilizer's attributes according to the system public key, the system private key, and a set of utilizer's attributes; an electronic medical cloud storage unit configured to receive and store a privacy-protected health file ciphertext; and at least one health file user access unit configured to encrypt the health file according to the system public key to obtain the privacy-protected health file ciphertext, and/or generate the set of utilizer's attribute, and decrypt the privacy-protected health file ciphertext according to the system public key and the private key for utilizer's attributes. The health file access control system and method in the electronic medical cloud provided by the present invention not only ensure the confidentiality of the health file, but also improve the security and calculation efficiency of the health file access. 1. A health file access control system in an electronic medical cloud , comprising:a medical management center unit configured to generate a system public key and a system private key, and generate a private key for corresponding utilizer's attributes according to the system public key, the system private key, and a set of utilizer's attributes sent by the at least one health file user access unit;an electronic medical cloud storage unit configured to receive and store a privacy-protected health file ciphertext sent by the at least one health file user access unit; andat least one health file user access unit configured to encrypt the health file according to the system public key sent by the medical management center unit to obtain the privacy-protected health file ciphertext, and/or generate the set of utilizer's attributes, and decrypt the privacy- ...

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Номер записи: 93
19-11-2020 дата публикации

METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE

Номер: US20200360483A1
Автор: Culler Michael DeWitt, Datta Rakesh, Dong Zheng Xin, Taylor John E.
Принадлежит: IPSEN PHARMA S.A.S.

The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin. 1. A method of treating inflammation in a subject in need thereof which comprises administering to said subject an effective amount of a peptidyl analogue of ghrelin , a prodrug thereof , or a pharmaceutically acceptable salt thereof wherein said analogue or said prodrug thereof is selected from the group consisting of:{'sup': '3', 'sub': '2', '(Dap(octanesulfonyl))hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, A6c)hGhrelin(1-28)-NH;'}{'sub': '2', '(A6c5)hGhrelin(1-28)-NH;'}{'sup': '2,6', 'sub': '2', '(Aib)hGhrelin(1-28)-NH;'}{'sup': 2', '12, 'sub': '2', '(Aib, A5c)hGhrelin(1-28)-NH;'}{'sup': 2', '12', '15, 'sub': '2', '(Aib, A5c, Orn)hGhrelin(1-28)-NH;'}{'sup': 2', '12', '16, 'sub': '2', '(Aib, A5c, Apc)hGhrelin(1-28)-NH;'}{'sup': 2', '6, 'sub': '2', '(Aib, Act)hGhrelin(1-28)-NH;'}{'sup': 2', '9, 'sub': '2', '(Aib, 3-Pal)hGhrelin(1-28)-NH;'}{'sup': 2', '7, 'sub': '2', '(Aib, Dmt)hGhrelin(1-28)-NH;'}{'sup': 2', '7, 'sub': '2', '(Aib, Thz)hGhrelin(1-28)-NH;'}{'sup': '2', 'sub': '2', '(A5c)hGhrelin(1-28)-NH;'}{'sup': '2', 'sub': '2', '(Act)hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, A5c)hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, A6c)hGhrelin(1-28)-NH;'}{'sup': '2,5', 'sub': '2', '(Aib)hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, hLeu)hGhrelin(1-28)-NH;'}{'sup': 2', '5, 'sub': '2', '(Aib, Cha)hGhrelin(1-28)-NH;'}{'sup': '2,6', 'sub': '2', '(Aib)hGhrelin(1-28)-NH;'}{'sup': 2', '6, 'sub': '2', '(Aib, Act)hGhrelin(1-28)-NH;'}{'sup': 2', '6, 'sub': '2', '(Aib, Thr)hGhrelin(1-28)-NH;'}{'sup': 2', '6, 'sub': '2', '(Aib, Abu)hGhrelin(1-28)-NH;'}{'sup': 2', '7, 'sub': '2', '(Aib, 4-Hyp)hGhrelin(1-28)-NH;'}{'sup ...

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Номер записи: 94
26-05-2010 дата публикации

Camptothecin-Somatostatin conjugates

Номер: EP2161037A3
Автор: Jeanne Mary Comstock, Sun H Kim, Yeelana Shen, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.

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Номер записи: 95
12-05-2009 дата публикации

PTH2 receptor selective compounds

Номер: US7531621B1
Автор: Michael Chorev, Michael Rosenblatt, Zheng Xin Dong
Принадлежит: Beth Israel Hospital Association, Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS

This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male infertility; regulation of abnormal blood pressure; and hypothalmic disease.

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Номер записи: 96
21-04-2009 дата публикации

GLP-1 pharmaceutical compositions

Номер: US7521527B2
Автор: Roland Cherif-Cheikh, Zheng Xin Dong
Принадлежит: Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS

The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

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Номер записи: 97
18-04-2012 дата публикации

GLP-1 pharmaceutical compositions

Номер: EP2441460A1
Автор: Frédéric LACOMBE, Jose-Antonio Cordero Rigol, Maria Dolores Tobalina Maestre, Resurreccion Alloza Miravete, Roland Cherif-Cheikh, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.

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Номер записи: 98
25-12-2013 дата публикации

Pharmaceutical compositions of hglp-1, exendin-4 and analogs thereof

Номер: EP2015769A4
Автор: Frédéric LACOMBE, Jose-Antono Cordero-Rigol, Maestre Maria Dolores Tobalina, Roland Cherif-Cheikh, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention is directed to pharmaceutical composition comprising a clear solution or an aqueous mixture, a suspension or a semisolid of at least one peptide compound selected from the group consisting of hGLP-1(7-36)-NH2 and analogs and derivatives thereof, hGLP-1(7-37)-OH and analogs and derivatives thereof and/or exendin-4 and analogs and derivatives thereof, zinc and solvent wherein at least 95% of the said peptide compound is dissolved by the solvent.

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Номер записи: 99
07-08-2012 дата публикации

GLP-1 pharmaceutical compositions

Номер: US8236759B2
Автор: Frédéric LACOMBE, Jose-Antonio Cordero Rigol, Maria Dolores Tobalina Maestre, Resurreccion Alloza Miravete, Roland Cherif-Cheikh, Zheng Xin Dong
Принадлежит: Ipsen Pharma SAS

The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.

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Номер записи: 100