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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 10. Отображено 10.
01-09-2010 дата публикации

Synthesizing method of high-purity 3-methyl-N-[4-(trifluoromethyl) phenyl]-4-isoxazol formamide

Номер: CN0101817797A
Автор: CHEN ZAIXIN, JIANG LONG, JING XIAOYAN, LIN SONG, MA YANQI, SHI HUIZHONG, WANG HANYUAN, XIA ZHENGJUN, YU HONGFEI, ZAIXIN CHEN, LONG JIANG, XIAOYAN JING, SONG LIN, YANQI MA, HUIZHONG SHI, HANYUAN WANG, ZHENGJUN XIA, HONGFEI YU
Принадлежит:

The invention relates to a synthesizing method of high-purity 3-methyl-N-[4-(trifluoromethyl) phenyl]-4-isoxazol formamide. The method can enhance the yield of 3-methyl-N-[4-(trifluoromethyl) phenyl]-4-isoxazol formamide greatly, and the product is easy to purify. Therefore, the method is beneficial to preparing the high-purity 3-methyl-N-[4-(trifluoromethyl) phenyl]-4-isoxazol formamide.

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Номер записи: 1
28-07-2010 дата публикации

Preparation method of 7(S)-Boc-amino-5-azaspiro [2,4] heptane

Номер: CN0101786981A
Автор: ZAIXIN CHEN, LONG JIANG, XIAOYAN JING, SONG LIN, YANQI MA, HUIZHONG SHI, ZHENGJUN XIA, HU YAO, HONGFEI YU, CHEN ZAIXIN, JIANG LONG, JING XIAOYAN, LIN SONG, MA YANQI, SHI HUIZHONG, XIA ZHENGJUN, YAO HU, YU HONGFEI
Принадлежит:

The invention relates to a preparation method of 7(S)-Boc-amino-5-azaspiro [2, 4] heptane which is an intermediate of broad-spectrum medicine sitafloxacin. The preparation method enables the reaction to be more easily controlled, and the optical purity of an obtained chiral isomer is higher.

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Номер записи: 2
01-09-2010 дата публикации

Novel environment-friendly process for preparing leflunomide

Номер: CN0101817798A
Автор: CHEN ZAIXIN, JIANG LONG, JING XIAOYAN, LIN SONG, MA YANQI, SHI HUIZHONG, WANG HANYUAN, XIA ZHENGJUN, YU HONGFEI, ZAIXIN CHEN, LONG JIANG, XIAOYAN JING, SONG LIN, YANQI MA, HUIZHONG SHI, HANYUAN WANG, ZHENGJUN XIA, HONGFEI YU
Принадлежит:

The invention relates to a novel environment-friendly process for preparing leflunomide, which can better control the content of 3-methylisomer and 4-trifluoromethylaniline in the leflunomide, has higher yield and is simpler. The process generates little industrial effluent and exhaust gas, is more environment-friendly and can effectively reduce production cost and corrosion to equipment.

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Номер записи: 3
02-05-2012 дата публикации

Process for producing hydrochloric berberine

Номер: CN0101245064B
Автор: TAO FENG, CHEN ZAIXIN, XIA ZHENGJUN, MA SHAOMING, FENG TAO, ZAIXIN CHEN, ZHENGJUN XIA, SHAOMING MA
Принадлежит:

The invention relates to a preparation method of berberine hydrochloride which is a broad spectrum antibiotic. The method takes 2, 3-dimethoxy benzyl alcohol and homopiperony lamine as raw materials to prepare the berberine hydrochloride by six steps of reaction, namely, alkylation, chloromethylation, cyanidation, alcoholysis, condensation and cyclization. The synthetic technology has easily available materials, high yield but low cost, thus being suitable for industrial production.

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Номер записи: 4
20-08-2008 дата публикации

Novel method for producing 2,4,5-trifluoro benzene acetic acid

Номер: CN0101244994A
Автор: CHEN ZAIXIN, XIA ZHENGJUN, JIANG LONG, TAO FENG, WANG SIQING, ZAIXIN CHEN, ZHENGJUN XIA, LONG JIANG, FENG TAO, SIQING WANG
Принадлежит:

The invention relates to a method for preparing pharmaceutical intermediate 2, 4, 5-trifluoro-benzene ethanoic acid, which adopts 1, 2, 4-trifluoro-benzene as raw material, and obtains the 2, 4, 5-trifluoro-benzene ethanoic acid (the content of final product is more than 99.9 percent) by Friede-crafts acetylating, Willegerodt-Kindler reaction and hydrolyzing. The new synthesis process is simple in technique, high in efficiency, mild in reaction condition, and safe in operation, and is suitable for industrial production.

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Номер записи: 5
28-07-2010 дата публикации

Method for preparing 2, 4-dichloro-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-alcohol

Номер: CN0101786942A
Автор: ZAIXIN CHEN, LONG JIANG, XIAOYAN JING, SONG LIN, HUIZHONG SHI, ZHENGJUN XIA, HU YAO, CHEN ZAIXIN, JIANG LONG, JING XIAOYAN, LIN SONG, SHI HUIZHONG, XIA ZHENGJUN, YAO HU
Принадлежит:

The invention relates to a method for preparing 2, 4-dichloro-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-alcohol which is a medicine of a nitrate eberconazole intermediate with broad spectrum antifungal activity. The method has the advantages of easy obtaining of used raw materials and easier controllable reaction, and is more suitable for industrial production.

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Номер записи: 6
16-09-2009 дата публикации

Splitting method of (+/-)-2-(1,6,7,8-tetrahydro-2H-indeno (5,4-b) furan-8-yl) ethylamine

Номер: CN0101531647A
Автор: CHEN ZAIXIN, JIANG LONG, XIA ZHENGJUN, ZAIXIN CHEN, LONG JIANG, ZHENGJUN XIA
Принадлежит:

The invention relates to a splitting method of (+/-)-2-(1,6,7,8-tetrahydro-2H-indeno (5,4-b) furan-8-yl) ethylamine of a medical and chemical intermediate. The method uses optically pure organic acid which has low price and is easy to obtain in market to split the (+/-)-2-(1,6,7,8-tetrahydro-2H-indeno (5,4-b) furan-8-yl) ethylamine so as to prepare optically pure (S)-2-(1,6,7,8-tetrahydro-2H-indeno (5,4-b) furan-8-yl) ethylamine with high optically purity. The splitting technique has simple and convenient operation and safety and is applicable to industrial production.

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Номер записи: 7
03-08-2011 дата публикации

Green new process for preparing tizanidine hydrochloride

Номер: CN0102140095A
Автор: ZAIXIN CHEN, MINGLIN WANG, ZHENGJUN XIA, LONG JIANG, MINGGUANG ZHANG, HONGFEI YU, YONGJUN WANG, XIAOBING LI, FENG TAO, SHUHANG XU, ZHIMIN ZHANG, CHEN ZAIXIN, WANG MINGLIN, XIA ZHENGJUN, JIANG LONG, ZHANG MINGGUANG, YU HONGFEI, WANG YONGJUN, LI XIAOBING, TAO FENG, XU SHUHANG, ZHANG ZHIMIN
Принадлежит:

The invention relates to a green new process for preparing a bulk pharmaceutical chemical, namely tizanidine hydrochloride. The green new process comprises the following steps: taking 4-chlorine-2-nitraniline as raw material and carrying out catalytic hydrogenation and reduction, cyclization, nitration, catalytic hydrogenation and reduction, condensation and salification on the raw material so as to obtain the tizanidine hydrochloride. The green new process not only has simple post-processing, is simple to operate, greatly reduces pollution to environment and corrosion on device, reduces production cost and is more suitable for industrial production.

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Номер записи: 8
02-06-2010 дата публикации

New method for preparing 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole

Номер: CN0101717370A
Автор: ZAIXIN CHEN, LONG JIANG, XIAOYAN JING, SONG LIN, YANQI MA, HUIZHONG SHI, ZHENGJUN XIA, HONGFEI YU, CHEN ZAIXIN, JIANG LONG, JING XIAOYAN, LIN SONG, MA YANQI, SHI HUIZHONG, XIA ZHENGJUN, YU HONGFEI
Принадлежит:

The invention relates to a new method for preparing 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole for industrialized use.

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Номер записи: 9
20-08-2008 дата публикации

Process for producing hydrochloric berberine

Номер: CN0101245064A
Автор: CHEN ZAIXIN, TAO FENG, XIA ZHENGJUN, MA SHAOMING, ZAIXIN CHEN, FENG TAO, ZHENGJUN XIA, SHAOMING MA
Принадлежит:

The invention relates to a preparation method of berberine hydrochloride which is a broad spectrum antibiotic. The method takes 2, 3-dimethoxy benzyl alcohol and homopiperony lamine as raw materials to prepare the berberine hydrochloride by six steps of reaction, namely, alkylation, chloromethylation, cyanidation, alcoholysis, condensation and cyclization. The synthetic technology has easily available materials, high yield but low cost, thus being suitable for industrial production.

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Номер записи: 10