Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 11. Отображено 11.
06-06-2023 дата публикации

Traditional Chinese medicine composition for treating verruca plana, traditional Chinese medicine preparation and application thereof

Номер: CN116211985A
Автор: WANG BIN, XU JINHUA, LI QUNYI, WU JINFENG, ZHONG MINGKANG, LI ZHONGDONG, XU LUYANG, CHEN HAIFEI, MA CHUNLAI, FU WENHUAN, GAO BO
Принадлежит:

The invention provides a traditional Chinese medicine composition for treating verruca plana, a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition comprises polygonum cuspidatum, oldenlandia diffusa, oyster, radix isatidis, lithospermum erythrorhizon, safflower carthamus, curcuma zedoary, curcuma aromatica and liquorice. The traditional Chinese medicine formula has the advantages that the traditional Chinese medicines are few in medicines, are all common traditional Chinese medicines, are easy to obtain and low in price, can effectively reduce the treatment cost of patients, are arranged in a proper manner and supplement one another, and have the advantages of thorough treatment of flat warts, no relapse, remarkable treatment effect, no obvious adverse reaction and the like, and the traditional Chinese medicine formula is worthy of popularization and application. The traditional Chinese medicine is especially suitable for patients ...

Подробнее
Номер записи: 1
29-04-2009 дата публикации

Method for simultaneously determining mycophenolic acid ester, mycophenolic acid and metabolite thereof in human blood plasma

Номер: CN0101419224A
Автор: YIJUN DAO, ZHENG JIAO, XIAOJIN SHI, ZHONGDONG LI, MINGKANG ZHONG, DAO YIJUN, JIAO ZHENG, SHI XIAOJIN, LI ZHONGDONG, ZHONG MINGKANG
Принадлежит:

The invention belongs to the field of medical test, and relates to a method for analyzing and measuring in vivo drugs, in particular to a method for measuring mycophenolate mofetil, mycophenolic acid and metabolites thereof in human plasma simultaneously. After the pretreatment of a sample to be measured, the method makes use of the characteristic of strong fluorescence absorption of the mycophenolate mofetil and the mycophenolic acid under an alkaline condition, performs derivatization after the analysis of chromatographic column separation, and detects with a fluorescence detector. The method can greatly improve the sensitivity for detecting the mycophenolate mofetil and the mycophenolic acid. The method has the advantages of few samples, simple pretreatment, rapidness, sensitivity, short analysis cycle and low cost, no needs of expensive equipment or reagents, and is suitable for clinical routine monitoring and pharmacokinetic study.

Подробнее
Номер записи: 2
26-02-2014 дата публикации

Method for detecting activation peroid markers of T lymphocyte in human peripheral blood

Номер: CN103604919A
Автор: JIAO ZHENG, FAN LINLIN, QIU XIAOYAN, ZHONG MINGKANG, ZHANG MING
Принадлежит:

The invention belongs to the technical field of medical tests, and relates to a method for simultaneously determining activation markers CD69, CD25 and CD71 of T lymphocyte in human peripheral blood by employing quantitative flow cytometry. The method comprises the following steps: firstly, cultivating and stimulating peripheral blood; then carrying out dyeing treatment on the cultivated and stimulated peripheral blood, and carrying out red blood cell cracking and washing on the dyed sample; and finally carrying out quantitative flow detection on the washed sample. Meanwhile, a standard curve is built according to QuantiBRITE PE microspheres, and specific expression quantity of antigens on each cell surface is calculated through the standard curve. By adopting the method disclosed by the invention, the antigen expression quantity of the CD69, CD25 and CD71 at the surface of the human T lymphocyte can be accurately and sensitively determined, and immunological characteristics of the detected ...

Подробнее
Номер записи: 3
29-04-2009 дата публикации

Method for simultaneously determining mycophenolic acid ester, mycophenolic acid and metabolite thereof in human urine

Номер: CN0101419225A
Автор: ZHENG JIAO, YIJUN DAO, XIAOJIN SHI, ZHONGDONG LI, MINGKANG ZHONG, JIAO ZHENG, DAO YIJUN, SHI XIAOJIN, LI ZHONGDONG, ZHONG MINGKANG
Принадлежит:

The invention belongs to the field of medical test, and relates to a method for analyzing and measuring in vivo drugs, in particular to a method for measuring mycophenolate mofetil, mycophenolic acid and metabolites thereof in urine simultaneously. After the pretreatment of a sample to be measured, the method makes use of the characteristic of strong fluorescence absorption of the mycophenolate mofetil and the mycophenolic acid under an alkaline condition, performs derivatization after the analysis of chromatographic column separation, and detects with a fluorescence detector. The method can greatly improve the sensitivity for detecting the mycophenolate mofetil and the mycophenolic acid. The method has the advantages of few samples, simple pretreatment, rapidness, sensitivity, no needs of expensive equipment or reagents, short analysis cycle and low cost, and is suitable for clinical routine monitoring and pharmacokinetic study.

Подробнее
Номер записи: 4
16-01-2008 дата публикации

Method for determining human plasma antiviral drug concentration

Номер: CN0101105478A
Автор: YIJUN DAO, ZHENG JIAO, MINGKANG ZHONG, DAO YIJUN, JIAO ZHENG, ZHONG MINGKANG
Принадлежит:

The invention belongs to medical detection field, relates to an analysis detection method of drug in the body of a person, and specifically relates to the method that the densities of antiviral drugs in blood plasma of the person such as acyclovir, ganciclovir and penciclovir can be detected at the same time. The method in the invention is characterized in that pilot sample is pretreated; as acyclovir, ganciclovir and penciclovir have the character of strong fluorescence absorption, acyclovir, ganciclovir and penciclovir can be separated from each other in an acidity flowing phase chromatographic column and be detected by a fluorescence detector. The method in the invention has the advantages of little sample, simple, swift and sensitive pretreatment, short analysis period and low cost; furthermore, the invention doesn't need expensive equipment and reagent and is suitable for the detection of clinical conventional blood drug density of acyclovir, ganciclovir and penciclovir.

Подробнее
Номер записи: 5
23-09-2015 дата публикации

Method for simultaneously determining human cyclosporine action target gene polymorphism

Номер: CN104928375A
Автор: QIU XIAOYAN, XU QINXIA, JIAO ZHENG, ZHONG MINGKANG
Принадлежит:

The invention provides a method for simultaneously determining human cyclosporine action target gene polymorphism, namely, a method for simultaneously determining cyclosporine action target pathway series protein coding gene multiple single nucleotide polymorphism (SNP) locus genotypes. Operation is simple and convenient, sequence specific probes are not required, multiple detection of 384 samples can be carried out by one chip, 40 reactions can be realized by each system at most, meanwhile, 40 SNP loci can be detected simultaneously, the flux can be adjusted individually according to requirements, the high flux is realized, the application range is wide, dozens of samples to tens of thousands of samples can be detected, and dozens of loci to hundreds of loci can be detected simultaneously, fluorescence labeling is not required, only common primers are required to be synthesized and the individual analysis cost is low; high flexibility is realized since samples and locus detection matching ...

Подробнее
Номер записи: 6
28-09-2005 дата публикации

Method for detecting drug resistant gene polymorphism of polydrug

Номер: CN0001673391A
Автор: ZHONG MINGKANG, LIANG HUIQI, JIAO ZHENG, MINGKANG ZHONG, HUIQI LIANG, ZHENG JIAO
Принадлежит:

The present invention belongs to the field of medical detection technology, relates to the clinical determination of individual genetype, and is especially the method of detecting multiple drug resistance gene polymorphism. The present invention detects the mononucleotide polymorphism of multiple drug resistance gene C3435T by means of high efficiency denatured liquid phase chromatographic technology and has sensitivity and specificity as high as 96-100 %, obviously higher that of available variation detecting technology, and detection result in accordance completely with that of DNA sequencing method. Compared with direct sequencing method, the method of the present invention has higher sensitivity and precision, faster speed and lower cost, and may be used in predicting the relation between blood drug level after administration and the genetype of the patient.

Подробнее
Номер записи: 7
22-08-2012 дата публикации

Method for simultaneously determining mycophenolic acid ester, mycophenolic acid and metabolite thereof in human blood plasma

Номер: CN0101419224B
Автор: ZHONGDONG LI, XIAOJIN SHI, MINGKANG ZHONG, YIJUN DAO, ZHENG JIAO, LI ZHONGDONG, SHI XIAOJIN, ZHONG MINGKANG, DAO YIJUN, JIAO ZHENG
Принадлежит:

The invention belongs to the field of medical test, and relates to a method for analyzing and measuring in vivo drugs, in particular to a method for measuring mycophenolate mofetil, mycophenolic acid and metabolites thereof in human plasma simultaneously. After the pretreatment of a sample to be measured, the method makes use of the characteristic of strong fluorescence absorption of the mycophenolate mofetil and the mycophenolic acid under an alkaline condition, performs derivatization after the analysis of chromatographic column separation, and detects with a fluorescence detector. The method can greatly improve the sensitivity for detecting the mycophenolate mofetil and the mycophenolic acid. The method has the advantages of few samples, simple pretreatment, rapidness, sensitivity, short analysis cycle and low cost, no needs of expensive equipment or reagents, and is suitable for clinical routine monitoring and pharmacokinetic study.

Подробнее
Номер записи: 8
25-03-2009 дата публикации

Method for simultaneously determining of concentration multi anesthesia medicament in blood plasma

Номер: CN0101393196A
Автор: WEIWEI QIN, ZHENG JIAO, MINGKANG ZHONG, XIAOJIN SHI, ZHONGDONG LI, XUEYAN CUI, QIN WEIWEI, JIAO ZHENG, ZHONG MINGKANG, SHI XIAOJIN, LI ZHONGDONG, CUI XUEYAN
Принадлежит:

The invention belongs to the field of medical examination and relates to a method capable of synchronously determining the concentrations of a plurality of local anesthetic drugs in human plasma. The method adopts a plasma cholineesterase inhibitor to inhibit the activity of plasma cholinesterase under ice bath condition below 3 DEG C, which controls the hydrolysis of totokaine and assures the accuracy of the method; by utilizing characteristics that lidocaine, ropivacaine and bupivacaine have stronger characteristic of ultraviolet absorption at wavelength of 210nm, and procaine and the totokaine have stronger characteristic of ultraviolet absorption at wavelength of 290nm, an ultraviolet dual-wavelength method is used to detect after the separation of an acid mobile phase at a chromatographic column; and the method can ensure that the sensitivity of synchronous determination of the local anesthetic drugs is greatly improved. The method has less sampling from samples and simple, quickand ...

Подробнее
Номер записи: 9
28-04-2023 дата публикации

Application of SLCO1B1 rs2306283 site polymorphism in evaluation of myelosuppression occurrence risk caused by methotrexate

Номер: CN116024346A
Автор: WU ZHUO, QIU XIAOYAN, DING TIANLING, WANG BIN, ZHONG MINGKANG
Принадлежит:

The invention provides an application of a substance for detecting SLCO1B1rs2306283 site polymorphism in preparation of a product for detecting or evaluating the risk that a person has a drug adverse reaction responding to methotrexate. The invention proves that the SLCO1B1rs2306283A/G allele is related to myelosuppression caused by methotrexate, can be used as an independent risk prediction factor for predicting myelosuppression caused by methotrexate of a patient with primary central nervous system lymphoma, and is used for screening high-risk persons with myelosuppression caused by methotrexate before methotrexate is used, so that clinical medication is guided, and clinical application of the methotrexate is promoted. Therefore, the occurrence of myelosuppression caused by methotrexate is reduced.

Подробнее
Номер записи: 10
13-01-2010 дата публикации

Method for determining human plasma antiviral drug concentration

Номер: CN0100580447C
Автор: DAO YIJUN, JIAO ZHENG, ZHONG MINGKANG, YIJUN DAO, ZHENG JIAO, MINGKANG ZHONG
Принадлежит:

The invention belongs to medical detection field, relates to an analysis detection method of drug in the body of a person, and specifically relates to the method that the densities of antiviral drugs in blood plasma of the person such as acyclovir, ganciclovir and penciclovir can be detected at the same time. The method in the invention is characterized in that pilot sample is pretreated; as acyclovir, ganciclovir and penciclovir have the character of strong fluorescence absorption, acyclovir, ganciclovir and penciclovir can be separated from each other in an acidity flowing phase chromatographic column and be detected by a fluorescence detector. The method in the invention has the advantages of little sample, simple, swift and sensitive pretreatment, short analysis period and low cost; furthermore, the invention doesn't need expensive equipment and reagent and is suitable for the detection of clinical conventional blood drug density of acyclovir, ganciclovir and penciclovir.

Подробнее
Номер записи: 11