30-04-2020 дата публикации
Номер: US20200129532A1
Methods are provided for reducing blood glucose, which utilize an agent that increases the biological activity of a vitamin D receptor (VDR) (e.g., a VDR agonist), in combination with an antagonist of bromodomain-containing protein 9 (BRD9). IN some examples, such methods treat type II diabetes. 1. A method of reducing blood glucose in a mammal , comprising:administering a therapeutically effective amount of one or more vitamin D receptor (VDR) agonists to the mammal, andadministering a therapeutically effective amount of one or more bromodomain-containing protein 9 (BRD9) antagonists to the mammal,thereby reducing blood glucose in the mammal.2. A method of treating type 2 diabetes in a mammal , comprising:administering a therapeutically effective amount of one or more vitamin D receptor (VDR) agonists to the mammal, andadministering a therapeutically effective amount of one or more bromodomain-containing protein 9 (BRD9) antagonists to the mammal,thereby treating type 2 diabetes in the mammal.3. A method , comprising:administering a therapeutically effective amount of one or more vitamin D receptor (VDR) agonists to a mammal, andadministering a therapeutically effective amount of one or more bromodomain-containing protein 9 (BRD9) antagonists to the mammal,wherein the method reduces fed and fasting blood glucose, increases insulin sensitivity, increases glucose tolerance, increases insulin secretion, increases beta cell function, increases the size of islets, reduced beta cell death, increases insulin granules, reduces fibrosis, treats an autoimmune disease, or combinations thereof, in the mammal.4. The method of claim 1 , wherein the therapeutically effective amount of the one or more VDR agonists is at least 0.01 mg/kg claim 1 , the therapeutically effective amount of the one or more BRD9 antagonists is at least 0.1 mg/kg claim 1 , or both.5. The method of claim 1 , wherein the administering is subcutaneous claim 1 , intraperitoneal claim 1 , intramuscular claim ...
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