Compound for Photoacid Generator, Resist Composition Using the Same, and Pattern-Forming Method

A sulfonic acid onium salt represented by the following formula (1) useful as a superior radiosensitive acid generator for resist compositions. It is possible to form a good pattern by using a resist composition containing this sulfonic acid onium salt corresponding to the formula (1): 5. A photoacid generator containing a fluorine-containing sulfonic acid onium salt according to .9. A resist composition according to claim 7 , wherein the base resin is a polymer prepared by polymerizing at least one monomer selected from the group consisting of olefins claim 7 , fluorine-containing olefins claim 7 , acrylates claim 7 , methacrylates claim 7 , fluorine-containing acrylates claim 7 , fluorine-containing methacrylates claim 7 , norbornene compounds claim 7 , fluorine-containing norbornene compounds claim 7 , styrene-series compounds claim 7 , fluorine-containing styrene-series compounds claim 7 , vinyl ethers and fluorine-containing vinyl ethers claim 7 , or copolymer prepared by copolymerizing at least two of the above monomers.11. A pattern-forming method characterized in containing the step of applying a resist composition according to on a substrate claim 7 , the step of exposing to a high energy ray having a wavelength of 300 nm or less through a photomask after a heating treatment claim 7 , and the step of developing using a developing solution claim 7 , after a heat treatment according to need.12. A pattern-forming method according to claim 11 , wherein said method is an immersion lithography in which an ArF excimer laser of a wavelength of 193 nm is used claim 11 , and in which water is inserted between wafer and a projector lens.13. Triphenylsulfonium 2-valeryloxy-1 claim 11 ,1-difluoroethanesulfonate. This application is a continuation of co-pending application Ser. No. 12/527,362, which is the US national stage of international application no. PCT/JP2008/052410, filed Feb. 14, 2008, the entire disclosure of which is incorporated herein by reference. Priority ...

DIFUNCTIONAL MONOMER COMPOUNDS CONTAINING CLICKABLE PENDANT FURYL GROUP AND POLYMERS THEREFROM

The present invention discloses novel difunctional monomers compound containing pendant clickable furyl group of formula (I), process for the preparation and polymers prepared there from. 2. The compound as claimed in claim 1 , wherein said difunctional monomer compound of formula (I) is selected froma) Dimethyl 5-((4-(furan-2-yl)butyl)oxy)isophthalate,b) Dimethyl 5-((6-(furan-2- yl)hexyl)oxy)isophthalate,c) 5-((4-(Furan-2-yl)butyl)oxy)isophthalic acid,d) 5-((6-(Furan-2- yl)hexyl)oxy)isophthalic acid,e) 5-((4-(Furan-2-yl)butyl)oxy)isophthaloyl azide,f) 5-((6-(Furan-2-yl)hexyl)oxy)isophthaloyl diazide,g) 2-(4-(3,5-Diisocyanatophenoxy)butyl)furan,h) 5-((4-(Furan-2-yl)butyl)oxy)isophthalohydrazide,i) 5-((6-(Furan-2-yl)hexyl)oxy)isophthalohydrazide,j) (5-((4-(Furan-2-yl)butyl)oxy)-1,3-phenylene)dimethanol,k) (5-((6-(Furan-2-yl)hexyl)oxy)-1,3-phenylene)dimethanol3. A process for the preparation of novel difunctional monomer compound of formula (I) as claimed in claim 1 , wherein said process comprising the steps of:a) reacting 5-hydroxyisophthalic acid with methanol in presence of sulfuric acid followed by heating the reaction at temperature in the range of 55 to 65° C. for the period of 8 to 10 h to afford dimethyl 5-hydroxyisophthalic;b) etherification of the phenolic hydroxyl group of compound of step (a) using α-bromo-ω-furyl alkane at a temperature in the range of 45 to 55° C. for the period of 6 to 9 h to afford intermediate diester;c) stirring the reaction mixture of intermediate diester of step (b) in ethanol and hydrazine hydrate at temperature in the range of 65 to 75° C. for the period in the range of 9 to 12 h to afford 5-((furan-2-yl)alkyl)oxy)isophthalohydrazide;d) subjecting intermediate diester of step (b) for reduction in presence of suitable reducing agent to afford (5-((furan-2-yl)alkyl)oxy-1,3-phenylene)dimethanol;e) hydrolyzing the intermediate diester of step (b) at a temperature in the range of 55 to 65° C. for the period of 10 to 12 h to afford ...

LIPOXYGENASE-CATALYZED PRODUCTION OF UNSATURATED C10-ALDEHYDES FROM POLYUNSATRURATED FATTY ACIDS

Described herein are methods for the lipoxygenase (LOX)-catalyzed production of aliphatic unsaturated C-aldehyde compounds from polyunsaturated fatty acid (PUFA) sources, and the isolation and characterization of novel, preferably bifunctional LOXs from different algae sources and the identification of structurally and/or functionally related LOXs from different bacterial sources. Also described herein are the provision of enzyme mutants derived from the newly identified enzymes, and corresponding coding sequences of the enzymes, recombinant vectors, and recombinant host cells suitable for the production of such LOXs and for performing the novel production methods of aliphatic unsaturated C-aldehyde compounds. Further describes herein is the use of particular aldehydes or aldehyde mixtures as a flavor ingredient or ingredient for food or feed compositions. 4. The method of claim 1 , wherein the polypeptide comprises an amino acid sequence selected froma) SEQ ID NO: 3, 6, 9, 12 or 15;b) SEQ ID NO: 18c) SEQ ID NO: 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, or 50; d) amino acid sequences having at least 40% sequence identity to at least one of the sequences of a), b) or c) and retaining said enzymatic activity of a lipoxygenase; ande) single and multiple mutants of anyone of the polypeptides c) retaining said enzymatic activity of a lipoxygenase.5. The method of claim 1 , wherein the polypeptide comprises the enzymatic activity of a bifunctional lipoxygenase.6. The method of claim 1 , wherein the polypeptide comprises the ability of converting at least one PUFA to at least one mono- or polyunsaturated aliphatic aldehyde.7. The method of claim 6 , wherein said decadienal is selected from 2E claim 6 ,4E-decadienal and 2E claim 6 ,4Z-decadienal and mixtures thereof; and wherein said decatrienal is selected from 2E claim 6 ,4E claim 6 , 7Z-decatrienal and 2E claim 6 ,4Z claim 6 ,7Z-decatrienal and mixtures thereof.8. The method of claim 1 , wherein said ...

NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT

The present disclosure relates to lipid compounds of the general formula (I): (I) wherein Ris selected from a C-Calkyl, a C-Calkenyl having 1-6 double bonds, and a C-Calkynyl having 1-6 triple bonds; Rand Rare the same or different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The disclosure also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area. 286-. (canceled) This application is a continuation of U.S. application Ser. No. 14/263,793, filed Apr. 28, 2014, a continuation of U.S. application Ser. No. 13/054,212, filed Apr. 13, 2011, now U.S. Pat. No. 8,759,558, which is the U.S. national stage application of International Application No. PCT/NO2009/000262, filed Jul. 13, 2009, which claims benefit of priority of U.S. Provisional Application No. 61/080,804 and European Application No. 08160450.6, which were filed Jul. 15, 2008, all of which are incorporated herein by reference.The present invention relates to lipid compounds of the general formula (I):whereinIn those cases were Rand Rare different, the compounds of formula (I) are capable of existing in stereoisomeric forms. It will be understood that the invention encompasses all optical isomers of the compounds of formula (I) and mixtures thereof.The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.Up to date, there has been a lot of research on fatty acid ...

SYNTHESIS OF DERIVATIVES OF DICARBAMATES FROM REDUCTION PRODUCTS OF 2-HYDROXYMETHYL-5-FURUFURAL (HMF)

Dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a non-aqueous solvent, with a miscible acid having a pKa of about 3.7 or less. The dicarbamates of HMF-reduction products can serve as precursor materials from which various derivative compounds can be synthesized. 2. A chemical compound derived from at least one of the precursor chemical compounds according to claim 1 , said derived chemical compound is a polymer containing said precursor chemical compound as a substituent.5. The method according to claim 4 , wherein said Lewis acid triflate is water-tolerant. The present application claims benefit of priority of U.S. patent application Ser. No. 14/781,364, filed Sep. 20, 2015, which claims priority from International Application No. PCT/US2014/037047, filed May 7,2014, which claims priority from U.S. Provisional Application No. 61/833,951, filed Jun. 12, 2013, the contents of each are herein incorporated.The present invention relates to a synthesis of precursor compounds for polymers. In particular, the present invention pertains to a method for preparing dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) (i.e, furan-2,5-dimethanol (FDM) and bis(hydroxymethyl)-tetrahydrofuran (bHMTHF)), and derivative compounds of such dicarbamates.Traditionally, polymers and commodity chemicals have been prepared from petroleum-derived feedstock. As petroleum supplies have become increasingly costly and difficult to access, interest and research has increased to develop renewable or “green” alternative materials from biologically-derived sources for chemicals that will serve as commercially acceptable alternatives to conventional, petroleum-based or -derived counterparts, or for producing the same materials as produced from fossil, non-renewable sources.Carbohydrates or sugars are ubiquitous in agricultural ...

Dental Materials Based on Monofunctional Vinylcyclopropane Derivatives

Dental material which contains at least one vinylcyclopropane of the general formulae I, 2. Dental material according to claim 1 , in which the variables have the following meanings:A OH,m 0, 1 or 2,{'sup': '1', 'sub': 1', '6, 'RH or a branched or linear C-Chydrocarbon radical which can be interrupted by O, or not interrupted by O, X O or NH,'}n 0,{'sup': '2', 'sub': 1', '3, 'Ra branched or linear C-Calkyl radical,'}Y O;orB OH,n 0, 1 or 2,{'sup': '2', 'sub': 1', '6, 'RH or a branched or linear C-Chydrocarbon radical which can be interrupted by O, or not interrupted by O,'}X O or NH,m 0,{'sup': '1', 'sub': 1', '3, 'Ra branched or linear C-Calkyl radical'}X O.3. Dental material according to claim 2 , wherein one or moreof the following exists:{'sup': '1', 'Ris not H if X=O and m=0,'}X is NH if m=0 and R1≠H,R2 is not H if Y=O and n=0.{'sup': '2', 'Y is NH if n=0 and R≠H,'}4. Dental material according to claim 2 , in which the variables have the following meanings:A OH,m 0 or 1,{'sup': '1', 'sub': 1', '6, 'RH or a linear C-Chydrocarbon radical,'}{'sup': '1', 'X O or NH, wherein X is NH if m=0 and R≠H,'}n 0,{'sup': '2', 'sub': 1', '3, 'Ra linear C-Calkyl radical'}Y O;orB OH,n 0 or 1,{'sup': '2', 'sub': 1', '6, 'RH or a linear C-Chydrocarbon radical,'}{'sup': '2', 'Y O or NH, wherein Y is NH if n=0 and R≠H,'}m 0,{'sup': '1', 'sub': 1', '3, 'Ra linear C-Calkyl radical,'}X O.5. Dental material according to claim 4 , wherein one or moreof the following exists:{'sup': '1', 'Ris not H if X=O and m=0,'}X is NH if m=0 and R1≠H,{'sup': '2', 'Ris not H if Y=O and n=0.'}6. Dental material which contains 2 to 95 wt.-% vinylcyclopropane(s) according to claim 1 , relative to the total mass of the material.7. Dental material according to claim 6 , which contains 5 to 85 wt.-% vinylcyclopropane(s).8. Dental material according to claim 6 , which contains 5 to to 70 wt.-% vinylcyclopropane(s).9. Dental material according to claim 6 , which contains 10 to 50 wt.-% vinylcyclopropane(s).10. ...

Radiolabelling Process

The present invention relates to a novel composition comprising 1-amino-3[F]-fluorocyclobutanecarboxylic acid ([F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [F]-FACBC. Also provided by the invention is a method to obtain said composition. 2. The method as defined in wherein said concentration of MeCN in said composition is no greater than 20 μg/mL.3. The method as defined in either wherein said composition has a radioactive concentration (RAC) of between 500-5000 MBq/ml.4. The composition as defined in wherein said composition has a RAC of between 1000-5000 MBq/ml.5. The composition as defined in wherein said composition has a radiochemical purity of at least 99%.7. The method as defined wherein LG is a linear or branched Chaloalkyl sulfonic acid substituent claim 1 , a linear or branched Calkyl sulfonic acid substituent claim 1 , a fluorosulfonic acid substituent claim 1 , or an aromatic sulfonic acid substituent.8. The method as defined in wherein LG is methanesulfonic acid claim 7 , toluenesulfonic acid claim 7 , nitrobenzenesulfonic acid claim 7 , benzenesulfonic acid claim 7 , trifluoromethanesulfonic acid claim 7 , fluorosulfonic acid claim 7 , or perfluoroalkylsulfonic acid.9. The method as defined in wherein LG is trifluoromethanesulfonic acid.10. The method as defined in wherein PGis a linear or branched Calkyl chain or an aryl substituent.11. The method as defined in wherein PGis methyl claim 10 , ethyl claim 10 , t-butyl and phenyl.12. The method as defined in wherein PGis methyl or ethyl.13. The method as defined in wherein PGis ethyl.14. The method as defined in wherein PGis a carbamate substituent claim 1 , an amide substituent claim 1 , an imide substituents claim 1 , or an amine substituents.15. The method as defined in wherein PGis t-butoxycarbonyl claim 14 , allyloxycarbonyl claim 14 , phthalimide claim 14 , or N-benzylideneamine.16. The method as defined in wherein PGis t- ...

Catalytic synthesis of reduced furan derivatives

The present invention relates to catalytic synthesis of furan derivatives from alkoxymethylfurfural ethers or acyloxymethylfurfural esters. More particularly, the invention pertains to furan derivatives obtained by use of a multifunctional catalyst system to carry out both hydrogenation of furan starting material and hydrolysis of the reduced furan derivative in a single reaction. The process allows recovering and recycling of alcohol or acid from the reaction product.

HYDROGENATION OF BIOMASS-DERIVED SUBSTRATES

The α,β-unsaturated ketone moiety of a substrate representative of non-food based biomass was hydrogenated to the corresponding saturated alcohol moiety using a composition including (1) a copper salt; (2) a phosphine; (3) a polar aprotic solvent such as acetonitrile, and (4) a compound suitable for providing hydrogen for the hydrogenation, such as a suitable silane material or a suitable siloxane material. 1. A composition effective for hydrogenation of an α ,β-unsaturated ketone moiety of a substrate comprising a furan ring , said catalyst prepared by combining a copper salt , a phosphine , a dry polar aprotic solvent , and a silane material or siloxane material , said silane material or siloxane material suitable for providing hydrogen for hydrogenation of the α ,β-unsaturated ketone moiety of a substrate.2. The composition of wherein the phosphine is selected from bis(diethylphosphino)ethane and 1 claim 1 ,3-bis(diisopropylphosphino)propane.3. The composition of claim 2 , wherein the copper salt comprises copper(II) fluoride.4. The composition of claim 2 , wherein the copper salt is copper(I) chloride and the composition further comprises a material that reacts with copper(I) chloride to provide a composition effective for hydrogenation of the α claim 2 ,β-unsaturated ketone moiety of the substrate comprising a furan ring.5. The composition of claim 1 , wherein the suitable silane material comprises phenyl silane.6. The composition of claim 1 , wherein the suitable siloxane material comprises polymethylhydrosiloxane.7. The composition of claim 1 , wherein the solvent comprises acetonitrile.8. A process for hydrogenation of an α claim 1 ,β-substituted moiety of a furan-containing substrate claim 1 , comprising reacting the substrate with a composition prepared by combining a copper salt claim 1 , a phosphine claim 1 , a polar aprotic solvent claim 1 , and a material suitable for providing hydrogen for the hydrogenation claim 1 , said suitable material selected ...

PREPARATION OF AMINOMETHYL FURANS AND ALKOXYMETHYL FURAN DERIVATIVES FROM CARBOHYDRATES

Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H, an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of Hin an aprotic solvent, such as dimethylformamide. With the same catalyst system and similar reaction conditions, 2,5 furan dialkylethers can also be made in a single step when the solvent includes an ROH alcohol. 123.-. (canceled)25. The method of wherein the organic solvent is a polar aprotic solvent claim 24 , the reaction mixture further includes Hthe temperature is 90-120° C. claim 24 , the pressure is 200-500 psi claim 24 , and the hydroxymethylfuran or tetrahydrofuran derivative is furandimethanol or tetrahydrofuran dimethanol26. The method of wherein the pressure is 400-600 psi claim 25 , and the time is 2-6 hours.27. The method of wherein the polar aprotic solvent comprises dimethylformamide.28. The method of wherein the organic solvent is a C1-C4 alcohol and the hydroxymethylfuran or tetrahydrofuran derivative is a 2 claim 24 ,5-furandiether or a 2 claim 24 ,5-tetrahydrofuran diether29. The method of wherein the temperature is 110-160 C claim 28 , the pressure is greater than 400 psi claim 28 , and the time is 1-4 hours.30. (canceled)31. The method of wherein the hydrogenation catalyst is a heterogeneous catalyst and the acid catalyst is a homogeneous mineral acid ...

USE OF GAMMA-QUATERNARY AMMONIUM BUTYRATE COMPOUND IN PREPARATION OF AN ANIMAL FEED ADDITIVE

Provided is an application of a γ-quaternary ammonium butyrate compound having formula (I) or a racemate, a stereoisomer, a geometric isomer, a tautomer, a solvate, or a feed-acceptable salt thereof in preparing an animal feed additive, the compound being added to the daily feed of animals at a certain concentration ratio, and being capable of increasing the average daily weight gain of animals under the same food intake conditions, having no significant effect on the daily feed intake of the animals, and reducing the feed-to-meat ratio. The γ-quaternary ammonium butyrate compound disclosed herein can effectively increase the rate of daily weight gain of the animals and improve the growth performance of the animals, having no side effects on the animals, being stable and safe, and improving the production efficiency of the breeding industry whilst ensuring the health of the animals.

SYNTHESIS OF SUBSTITUTED FURANS

A method is provided of preparing a compound of formula II: where: Rand Rare independently selected from —CH2OR′, —CHO, —COOR′ and —H, provided that Rand Rare not both —H; and R′ is selected from —H and Chydrocarbyl groups, from a compound of formula I: the compounds of formulas I and II being optionally in the form of a salt. The method comprises dehydrating the compound of formula I at: a pH in the range of from 0 to 6 or 8 to 11.5; and a temperature in the range of from 10 to 80° C. The method is particularly useful for synthesizing substituted furans from compounds derived from sugars. 2. The method of claim 1 , wherein the dehydration reaction is carried out at a temperature in the range of from 15 to 70° C. claim 1 , preferably from 20 to 55° C. claim 1 , and more preferably from 25 to 50° C.3. The method of claim 1 , wherein the dehydration reaction is carried out at a pH in the range of from 1.5 to 5 claim 1 , preferably from 1.75 to 4 claim 1 , and more preferably from 2 to 3.5 claim 1 , and preferably in the presence of an acid selected from:{'sub': '1-6', 'organic acids, such as from Ccarboxylic acids; and'}inorganic acids, such as from hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid and hydrobromic acid.4. The method of claim 1 , wherein the dehydration reaction is carried out at a pH in the range of from 8.5 to 11.5 claim 1 , preferably from 9 to 11 claim 1 , and more preferably from 9.5 to 10.5 claim 1 , and preferably in the presence of a base selected from:nitrogen-containing bases (e.g. ammonia, an amine or a nitrogen-containing heterocycle); andmetal-containing bases (e.g. a metal hydroxide, a metal oxide or a metal carbonate).5. The method of claim 1 , wherein the dehydration reaction is carried out in the presence of:a heterogeneous, preferably solid-phase, catalyst; and/ora buffer preferably selected from a citrate buffer, a formate buffer, an acetate buffer, a carbonate buffer, a phosphate buffer, an N-cyclohexyl-2- ...

Bioderived based plasticizers

A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N′-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, α-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and α-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers.

FURAN MONOMER HAVING BIFUNCTIONAL HYDROXYMETHYL GROUP AND PREPARATION METHOD THEREFOR

The present disclosure relates to a method of preparing a furan monomer having a bifunctional hydroxymethyl group (2, 5-bis(hydroxymethyl) furan (BHMF)). The method includes converting furfuryl alcohol to a low-molecular weight furan mixture extracting and purifying the furan monomer having a bifunctional hydroxymethyl group from the low-molecular weight furan mixture. 1. A method of preparing a furan monomer having a bifunctional hydroxymethyl group (2 , 5-bis(hydroxymethyl) furan (BHMF)) , the method comprising:converting furfuryl alcohol to a low-molecular weight furan mixture; andextracting and purifying the furan monomer having a bifunctional hydroxymethyl group from the low-molecular weight furan mixture.2. The method of claim 1 , wherein converting comprises hydroxymethylating the furfuryl alcohol by mixing the furfuryl alcohol claim 1 , solid-phase formaldehyde claim 1 , and an acid catalyst.3. The method of claim 2 , wherein the solid-phase formaldehyde comprises paraformaldehyde.4. The method of claim 3 , wherein the hydroxymethylating allows the furfuryl alcohol to be associated with monomeric formaldehyde produced by thermal degradation of the paraformaldehyde.5. The method of claim 2 , wherein the hydroxymethylating is conducted at a temperature of 100° C. to 150° C.6. The method of claim 2 , wherein the furfuryl alcohol is mixed at a 2- to 30-fold greater molar ratio to the formaldehyde.7. The method of claim 2 , wherein the acid catalyst is mixed in an amount of 0.05 phr to 0.3 phr relative to the furfuryl alcohol.8. The method of claim 2 , wherein the acid catalyst is an organic acid with a pKa of 3.0 to 6.4 and is selected from the group consisting of acetic acid claim 2 , acetoacetic acid claim 2 , adipic acid claim 2 , azelaic acid claim 2 , benzoic acid claim 2 , citric acid claim 2 , cyclohexanecarboxylic acid claim 2 , enolpyruvic acid claim 2 , formic acid claim 2 , fumaric acid claim 2 , galactaric acid claim 2 , galactonic acid claim 2 , ...

PROCESS FOR CONVERTING BIO-OIL

Disclosed is a process for converting bio-oil, wherein the process includes the steps, where a feedstock including bio-oil selected from bio-oils, any fractions of bio-oils and any combinations thereof is subjected to azeotropic distillation with at least one alcohol to yield a liquid component, and subjecting the liquid component to alcoholysis whereby converted bio-oil is obtained. The invention also relates to the use of converted bio-oil, obtainable by the process, as heating oil, as starting material in processes for producing fuels, fuel components, fine chemicals, chemical building-blocks, and solvents.

Radiolabelling Process

The present invention relates to a novel composition comprising 1-amino-3-[F]-fluorocyclobutanecarboxylic acid ([F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [F]-FACBC. Also provided by the invention is a method to obtain said composition. 1. A composition comprising 1-amino-3-[F] fluorocyclobutanecarboxylic acid ([F]-FACBC) and no greater than 50 μg/mL acetonitrile (MeCN).2. The composition of claim 1 , wherein said concentration of MeCN is no greater than 20 μg/mL.3. The composition of claim 1 , having a radioactive concentration (RAC) of between 500-5000 MBq/mL.4. The composition of claim 1 , having a RAC between 1000-5000 MBq/mL.5. The composition of claim 1 , having a radiochemical purity of at least 99%.7. The composition of claim 6 , wherein said concentration of MeCN is no greater than 20 μg/mL.8. The composition of claim 6 , having a radioactive concentration (RAC) of between 500-5000 MBq/mL.9. The composition of claim 6 , having a RAC between 1000-5000 MBq/mL.10. The composition of claim 6 , having a radiochemical purity of at least 99%. The invention relates to a method for the preparation of a radiopharmaceutical compound, in particular an amino acid derivative useful as a positron emission tomography (PET) tracer. The method of the invention is especially suitable when automated and offers advantages over known methods. Particularly, the invention relates to a method for preparation of [F]-1-amino-3-fluorocyclobutane-1-carboxylic acid ([F]-FACBC, also known as [F]-fluciclovine).The non-natural amino acid [F]-1-amino-3-fluorocyclobutane-1-carboxylic acid ([F]-FACBC, also known as [F]-Fluciclovine) is taken up specifically by amino acid transporters and has shown promise for tumour imaging with positron emission tomography (PET).A known synthesis of [F]-FACBC (EP2017258) begins with the provision of the protected precursor compound 1-(N-(t-butoxycarbonyl)amino)-3-[((trifluoromethyl) ...

Pyrethroid Insecticide For Protecting Plants And Seed

The present invention relates to pyrethroid insecticides and the stereoisomers thereof and to compositions comprising the same. The invention also relates to the use of the insecticides or compositions comprising such insecticides for combating invertebrate pests. Furthermore, the invention relates to methods of applying such insecticides. 2. The compound of formula (I) according to claim 1 , wherein Rand Rare independently selected from the group consisting of chlorine and flourine.3. The compound of formula (I) according to claim 1 , wherein Ris selected from the group consisting of C-C-chloroalkyl and C-C-fluoroalkyl.4. The compound of formula (I) according to claim 1 , wherein R is trifluoromethyl.5. The compound of formula (I) according to claim 1 , wherein Rand Rare independently selected from the group consisting of chlorine claim 1 , C-C-chloroalkyl claim 1 , and C-C-fluoroalkyl.6. The compound of formula (I) according to claim 1 , wherein at least one of Rand Rare chlorine.7. The compound of formula (I) according to claim 1 , wherein Ris chlorine claim 1 , Ris trifluoromethyl claim 1 , Rand Rare fluorine claim 1 , and Ris trifluoromethyl.8. The compound of formula (I) according to claim 1 , wherein Rand Rare chlorine claim 1 , Rand Rare fluorine claim 1 , and Ris trifluoromethyl.9. An agricultural composition comprising at least one compound as defined in or a stereoisomer thereof and at least one auxiliary.10. A method for protecting growing plants from attack or infestation by invertebrate pests comprising contacting the plant or soil or water in which the plant is growing with a pesticidally effective amount of a compound as defined in .11. A method for the protection of plant propagation material from pests comprising contacting the plant propagation material with a pesticidally effective amount of a compound as defined in .12. Plant propagation material comprising a compound as defined in in an amount of from 0.1 g to 10 kg per 100 kg of the plant ...

SINGLE STEP PROCESS FOR THE SYNTHESIS OF FURFURYL ETHYL ETHER

The present invention provides a single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol, ethanol and catalyst at temperature in the range of 80 to 120° C. for the period in the range of 3 to 7 hrs to afford furfuryl ethyl ether. The catalyst used in present invention is Zr incorporated SBA-15. Further, the conversion of furfuryl alcohol is in the range of 60 to 90%. The selectivity of reaction towards furfuryl ethyl ether is in the range of 85 to 95%. 1. A single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol , ethanol and Zr incorporated SBA-15 catalyst at temperature in the range of 80 to 120° C. for the period in the range of 3 to 7 hrs to afford furfuryl ethyl ether , wherein selectivity of said reaction towards furfuryl ethyl ether is in the range of 85 to 95%.2. The process as claimed in claim 1 , wherein said reaction is carried out at temperature in the range of 90 to 100° C.3. The process as claimed in claim 1 , wherein said reaction is carried out for the period in the range of 5 to 6 hrs.4. The process as claimed in claim 1 , wherein conversion of furfuryl alcohol is in the range of 60 to 90%. This application is related to and claims the benefit of Indian Patent Application Number 201811007111 filed on Jan. 18, 2018, the entire content of which is incorporated herein by reference.The present invention relates to a process for the synthesis of furfuryl alkyl ether. More particularly, the present invention relates to a single step process for the synthesis of furfuryl ethyl ether from furyl alcohol in presence of mesoporous Zr-incorporated SBA-15 catalyst.Furfuryl ethyl ether (FEE) is a bio-based transportation fuel component and an important blend in gasoline. FEE has superior anti-knock quality to the reference Euro95 gasoline. Furfuryl ethyl ether is an important flavor compound indicative of beer storage and aging ...

METHOD FOR SYNTHESISING 2,5-DI(HYDROXYMETHYL)FURAN AND 2,5-DI(HYDROXYMETHYL)TETRAHYDROFURAN BY SELECTIVE HYDROGENATION OF FURAN-2,5-DIALDEHYDE

A method for selective hydrogenation of furan-2,5-dialdehyde (DFF) into 2,5-di(hydroxymethyl)furan (DHMF) and into 2,5-di(hydroxymethyl)tetrahydrofuran (DHMTHF). In relation to the prior art, which uses C6 sugars or 5-hydroxymethyl furaldehyde (5-HMF) as raw materials, the method can be performed at low temperatures (lower than 120° C., preferably 80° C.), while consuming low amounts of catalyst relative to the initial reagent (in particular less than 5%, preferably less than 2% relative to the weight of the reagent). The heterogeneous catalyst used can also be recycled from one reaction to another. Finally, the choice of experimental conditions enables the selective formation of DHMF or DHMTHF. 111-. (canceled)12. A process for synthesizing 2 ,5-di(hydroxymethyl)furan (DHMF) and/or 2 ,5-di(hydroxymethyl)tetrahydrofuran DHMTHF , by bringing into contact:a) a composition containing furan-2,5-dialdehyde (DFF),b) a protic solvent,c) a source of hydrogen,d) and a hydrogenation catalyst.13. The process as claimed in claim 12 , wherein the composition a) has a content of DFF by weight at least equal to 90% claim 12 , preferably 95% claim 12 , very preferably 98%.14. The process as claimed in claim 12 , wherein the composition a) is derived from the oxidation of 5-hydroxymethyl furaldehyde (5-HMF) in the presence of at least an organic acid claim 12 , a nitroxyl radical claim 12 , a source of oxygen and an oxygen transfer agent.15. The process as claimed in claim 12 , wherein the protic solvent b) is selected from water claim 12 , methanol claim 12 , ethanol claim 12 , isopropanol claim 12 , 1-propanol claim 12 , 1-butanol and the mixtures of these solvents claim 12 , water being preferred.16. The process as claimed in claim 12 , wherein the synthesis reaction via hydrogenation takes place at a temperature between 30° C. and 180° C. claim 12 , preferably between 30° C. and 150° C. claim 12 , more preferably between 50° C. and 120° C.17. The process as claimed in claim 12 , ...

NOVEL DISUBSTITUTED ADAMANTYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION FOR SUPPRESSING CANCER METASTASIS COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel disubstituted adamantyl derivative or the pharmaceutically acceptable salts thereof, a method for preparing the same, and a pharmaceutical anticancer or antimetastasis composition comprising the same as an active ingredient. The disubstituted adamantyl derivative of the present invention suppressed accumulation of HIF-1α, inhibiting the expression of the metastasis related protein Twist dose-dependently. Thus, the disubstituted adamantyl derivative of the invention is effective in inhibiting the expressions of the metastasis related proteins, β-catenin and RohA, and the EMT related genes such as MMP2 and MMP9, without cytotoxicity. Therefore, the disubstituted adamantyl derivative or the pharmaceutically acceptable salts thereof of the invention can be efficiently used as a pharmaceutical anticancer or antimetastasis composition. 2. The disubstituted adamantyl derivative represented by formula 1 or a pharmaceutically acceptable salt thereof according to claim 1 , wherein:{'sup': 1', '3, 'sub': 2', 'n, 'Ris —X—(CH)—R;'}{'sup': '2', 'Ris H or C1-C4 straight or branched alkyl;'}{'sup': '3', 'Ris unsubstituted or substituted phenyl, unsubstituted or substituted pyridine, pyrazine, imidazole, thiophene, benzothiophene, furan, or benzofuran,'}wherein the substituted phenyl or the substituted pyridine, pyrazine, imidazole, thiophene, benzothiophene, furan or benzofuran is optionally substituted with one or more fluoro, bromo, chloro, methyl, ethyl, propyl, isopropyl, butyl, hydroxy, t-butyl, methoxy, ethoxy, propoxy, butoxy, nitro, nitrile, amine, methylamine, dimethylamine, ethylamine, diethylamine, acetyl, ethylcarbonyl or 5-membered or 6-membered heterocycloalkyl comprising heteroatoms selected from the group consisting of N, O, and S;{'sup': '3', 'X is NH or O, provided that when Ris unsubstituted or substituted aryl X is O; and'}n is an integer of 1-3.3. The disubstituted adamantyl derivative represented by formula 1 or a ...

BIODERIVED BASED PLASTICIZERS

A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N′-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, α-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and α-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers. 17-. (canceled)8. A method of producing a bioderived based plasticizer , comprising:reacting a bioderived diol and a bioderived carboxylic acid in the presence of N,N′-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil.9. The method as recited in claim 8 , wherein the bioderived diol is selected from the group consisting of 2 claim 8 ,5-bis(hydroxymethyl)furan claim 8 , 2 claim 8 ,5-bis(hydroxymethyl)tetrahydrofuran claim 8 , isosorbide claim 8 , and mixtures thereof.11. The method as recited in claim 10 , wherein the bioderived carboxylic acid includes a hydrolyzed oil selected from the group consisting of linoleic acid claim 10 , α-linolenic acid claim 10 , oleic acid claim 10 , and mixtures thereof.12. The method as recited in claim 11 , wherein the bioderived diol includes 2 claim 11 ,5-bis(hydroxymethyl)furan.13. The method as recited in claim 8 , further comprising:hydrolyzing a triglyceride to produce the bioderived carboxylic acid.14. The method as recited in claim 13 , wherein the triglyceride is selected from the group consisting of canola oil claim 13 , corn oil claim 13 , cottonseed oil claim 13 , linseed oil claim 13 , peanut oil claim 13 , safflower oil ...

BIODERIVED BASED PLASTICIZERS

A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N′-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, α-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and α-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers. 1. A bioderived based plasticizer , comprising:a reaction product of a bioderived diol and a bioderived carboxylic acid in the presence of N,N′-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil.2. The bioderived based plasticizer as recited in claim 1 , wherein the bioderived diol is selected from the group consisting of 2 claim 1 ,5-bis(hydroxymethyl)furan claim 1 , 2 claim 1 ,5-bis(hydroxymethyl)-tetrahydrofuran claim 1 , isosorbide claim 1 , and mixtures thereof.4. The bioderived based plasticizer as recited in claim 3 , wherein the bioderived carboxylic acid includes a hydrolyzed oil selected from the group consisting of linoleic acid claim 3 , α-linolenic acid claim 3 , oleic acid claim 3 , and mixtures thereof.5. The bioderived based plasticizer as recited in claim 4 , wherein the bioderived diol includes 2 claim 4 ,5-bis(hydroxymethyl)furan.7. The bioderived based plasticizer as recited in claim 1 , wherein the reaction product contains a trace amount of at least one of DCC and dicyclohexylurea (DCU).8. An article of manufacture comprising:an admixture includes a polymer and a bioderived based plasticizer, wherein the bioderived based plasticizer comprises a ...

PALLADIUM, RHENIUM AND ALUMINA CATALYSTS FOR THE SELECTIVE HYDROGENATION OF CARBONYLS, THEIR SYNTHESIS, AND METHODS OF USING THE SAME

Catalysts useful for the selective hydrogenation of carbonyl groups, including for the reduction of aldehydes to alcohols, are described. The catalysts incorporate palladium and rhenium on an alumina support. Methods of making the catalysts, and methods of using the catalysts for the selective hydrogenation of furanyl 2-carbaldehydes to 2-furanmethanols, are also presented. 2. The catalyst of claim 1 , wherein the amount of rhenium in the catalyst is between about 4% and about 7% by weight claim 1 , and wherein the amount of palladium in the catalyst is between about 0.5% and about 5% by weight.3. The catalyst of claim 1 , wherein the aldehyde is a furan-2-carbaldehyde.4. The catalyst of claim 3 , wherein the furan-2-carbaldehyde is furfural or 5-(hydroxymethyl)furfural.5. The catalyst of claim 1 , wherein the palladium is adsorbed to the alumina support by contacting the alumina with a solution of Pd(NH)(NO).6. The catalyst of claim 1 , wherein the palladium is adsorbed to the alumina support by contacting the alumina with a solution of Pd(NO).7. The catalyst of claim 1 , wherein the alumina support comprises gamma-alumina.8. A method of making a catalyst for the hydrogenation of an aldehyde claim 1 , comprisinga) contacting an alumina support with a solution comprising rhenium to provide a first composition comprising an alumina support with rhenium absorbed thereto, andb) contacting the first composition with a solution comprising palladium to provide a second composition.9. The method of claim 8 , wherein the first composition is calcined prior to contacting the first composition with a solution comprising palladium.10. The method of claim 8 , wherein the solution of palladium has a pH of between about 9 and about 11.11. The method of claim 8 , wherein the amount of rhenium in the catalyst is between about 4% and about 7% by weight claim 8 , and wherein the amount of palladium in the catalyst is between about 0.5% and about 5% by weight.12. The method of claim 8 ...

FURFURYL-BASED ESTERS

The reactions are disclosed of furfuryl alcohol in the presence of catalyst with aliphatic diacid esters or aliphatic diacid anhydrides to synthesize diesters and monoesters, respectively. The reaction is disclosed of the monoester in the presence of catalyst with alkanols to synthesize diesters. The two types of diesters and the monoesters are proven to be suitable as plasticizers for polymers, particularly polylactic acid. Thermoplastic compounds are disclosed using the esters as plasticizers. 2. The composition of matter of claim 1 , wherein R′ is hydrogen claim 1 , and wherein the composition of matter is a monoester.3. The composition of matter of claim 1 , wherein R′ is an alkyl having from 2 to 10 carbon atoms claim 1 , and wherein the composition of matter is a diester.4. The composition of matter of claim 1 , wherein the composition of matter selected from the group consisting of 4-(furan-2-ylmethoxy)-4-oxobutanoic acid and 1-butyl 4-furan-2-ylmethyl butanedioate.5. The composition of matter of claim 4 , wherein the composition of matter is 4-(furan-2-ylmethoxy)-4-oxobutanoic acid.6. The composition of matter of claim 4 , wherein the composition of matter is 1-butyl 4-furan-2-ylmethyl butanedioate.7. A composition of matter comprising: 1 claim 4 ,4-bis(furan-2-ylmethyl) butanedioate synthesized by an organometallic-catalyzed transesterification reaction of furfuryl alcohol and diethyl succinate in the presence of titanium isopropoxide.8. The composition of matter of claim 5 , wherein the 4-(furan-2-ylmethoxy)-4-oxobutanoic acid is synthesized by a base-catalyzed ring-opening esterification reaction of furfuryl alcohol and succinic anhydride in the presence of a catalyst selected from the group consisting of pyridine claim 5 , triethylamine claim 5 , and dimethylaminopyridine.9. The composition of matter of claim 6 , wherein the 1-butyl 4-furan-2-ylmethyl butanedioate is synthesized by an acid-catalyzed direct esterification reaction of a furfuryl monoester ...

Method for Acid-Catalyzed Acylation of the Reduction Products of 5-HydroxyMethyl Furfural

An improved process for acid-catalyzed acylation using water-tolerant Lewis acid catalysts is described. The method involves reacting a reduction products of 5-(hydroxylmethyl)-furfural (HMF), in particular either furan-2,5-dimethanol (FDM) or bis-2,5-(hydroxymethyl)-tetrahydrofuran (bHMTHFs), with an excess of an organic acid in the presence of a Lewis acid metal triflate at a temperature and time sufficient to produce esters. The conversions of the reduction products of HMF to corresponding diesters can be quantitative with certain favored Lewis acids catalysts. 1. A method for acid-catalyzed acylation of a reduction product of 5-(hydroxylmethyl)-furfural (HMF) comprising: contacting the reduction product of HMF with an excess of an organic acid in the presence of a water-tolerant Lewis acid catalyst at a reaction temperature and for a time sufficient to produce a corresponding ester product mixture.2. The method according to claim 1 , wherein said reduction product of HMF is either furan-2 claim 1 ,5-dimethanol (FDM) or bis-2 claim 1 ,5-hydroxymethyl-tetrahydrofuran (bHMTHF).3. The method according to claim 1 , wherein said organic acid is selected from the group consisting of an alkanoic acid claim 1 , alkenoic acid claim 1 , alkyonoic acid claim 1 , and aromatic acid claim 1 , having a carbon chain length ranging from C-C.4. The method according to claim 1 , wherein said organic acid is selected from the group consisting of 2-ethylhexanoic acid claim 1 , hexanoic acid claim 1 , and octanoic acid.5. The method according to claim 1 , wherein said reaction temperature is from about 150° C. to about 250° C.6. The method according to claim 5 , wherein said reaction temperature is from about 170° C. to about 220° C.7.8. The method according to claim 1 , wherein said reaction time is between 0.5 and 12 hours.9. The method according to claim 8 , wherein said reaction time is between about 1-4 hours.10. The method according to claim 1 , wherein ≧55% of said reduction ...

CATALYST AND CATALYTIC PROCESS FOR THE ETHERIFICATION/REDUCTION OF FURFURYL DERIVATIVES TO TETRAHYDROFURFURYL ETHERS

The invention relates to a method for producing tetrahydrofurfuryl ethers, characterised in that it involves carrying out consecutive etherification/reduction reactions based on a compound containing at least one furan ring, in the presence of at least one alcohol and at least one catalyst, optionally in the presence of H. The catalytic process can be carried out in a cascade reaction (“one-pot”), operating under soft reaction conditions and without a solvent. 3. The process according to claim 2 , wherein a compound of tetrahydro-furfuryl ether type having 6 to 24 carbon atoms is obtained.4. The process according to wherein the furan compound contains a furan ring (mono-furan).5. The process according to claim 4 , wherein the mono-furan compound is selected from furfural claim 4 , 5-hydroxymethylfurfural claim 4 , 5-methoxymethyl furfural claim 4 , 5-ethoxymethyl furfural claim 4 , and combinations thereof.7. The process according to claim 6 , wherein the alcohol is selected from: an aliphatic primary alcohol having 2 to 12 carbon atoms claim 6 , an aliphatic secondary alcohol having 2 to 12 carbon atoms claim 6 , and combinations thereof.8. The process according to claim 1 , wherein the hydrogen is derived from a source selected from molecular hydrogen claim 1 , a gas mixture containing hydrogen claim 1 , and combinations thereof.9. The process according to wherein the catalyst is selected from:a) a metallic catalyst “CAT A” comprising one or more noble metals, or one or more transition metals, or one or more of its salts or complexes, and combinations thereof, with the aforementioned “CAT A” being supported, or included in a carbonaceous type solid or in the structure of an inorganic matrix;b) a metallic catalyst “CAT B” comprising one or more transition metals, their salts or complexes, included within or supported on an inorganic matrix structure;c) a metallic catalyst “CAT C” comprising at least one noble metal and one or more transition metals, or one or more ...

ORTHOFORMIC ACID ESTERS AS PRO-FRAGRANCES

The disclosure relates to special orthoformic acid esters of formula (I), as defined herein, which can be used as thermally labile and acid-labile fragrance storage substances. The disclosure further relates to detergents and cleaning agents, cosmetic agents and air freshening products containing such orthoformic acid esters, as well as to a method for lastingly fragrancing surfaces. 2. The compound according to claim 1 , wherein Rand Rare independently selected from the group of:substituted or unsubstituted, linear or branched alkyl, alkenyl or alkynyl having up to 20 carbon atoms;substituted or unsubstituted, linear or branched heteroalkyl, heteroalkenyl or heteroalkynyl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N;substituted or unsubstituted aryl having up to 20 carbon atoms;substituted or unsubstituted heteroaryl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N;cycloalkyl or cycloalkenyl having up to 20 carbon atoms; andheterocycloalkyl or heterocycloalkenyl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N.3. The compound according to claim 1 , wherein Ris{'sup': 3', '3', '3, 'sub': 2', '2', '2, 'claim-text': hydrogen, substituted or unsubstituted, linear or branched alkyl, alkenyl or alkynyl having up to 20 carbon atoms,', 'substituted or unsubstituted, linear or branched heteroalkyl, heteroalkenyl or heteroalkynyl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N,', 'substituted or unsubstituted aryl having up to 20 carbon atoms,', 'substituted or unsubstituted heteroaryl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N, and', 'cycloalkyl or cycloalkenyl having up to 20 carbon atoms, and heterocycloalkyl or heterocycloalkenyl having up to 20 carbon atoms, and 1 to 6 heteroatoms selected from O, S and N;, 'a. a residue of formula —C(O)—R, —CH—C(O)—R, -aryl, -heteroaryl, —CH-aryl or —CH-heteroaryl, wherein Ris ...

拟除虫菊酯化合物及应用

本发明涉及一种拟除虫菊酯化合物，以及这几种化合物的制备方法及其在卫生杀虫产品中的应用。其通式为(A)，式中R 1 为甲基、甲氧基甲基(－CH 2 OCH 3 )或者H原子，R 2 为－CF 3 或－COOCH(CF 3 ) 2 。实验表明，通式为(A)的化合物对蚊、蝇、德国小蠊等卫生害虫有很好的防治效果。

Method for promoting growth and reducing fat in animals using phenylethanolamine derivatives

NOVEL BIO-BASED DIOLS FROM SUSTAINABLE RAW MATERIALS, USES THEREOF TO MAKE DIGLYCIDYL ETHERS, AND THEIR COATINGS

The invention relates to diols derived from 5-hydroxymethyl furfural, diformyl furan, or derivatives thereof. The invention further relates to diglycidyl ethers derived from the diols of the invention, curable coating compositions containing the diglycidyl ethers, and objects coated with the curable coating compositions. The invention also relates to composites, composites, adhesives, and films containing the diglycidyl ethers of the invention. The invention also relates to methods of making the diols, diglycidyl ethers, and curable coating compositions. 2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. A method of making a diol of claim 1 , comprising claim 1 , consisting essentially of claim 1 , or consisting of:reacting 5-hydroxymethyl furfural (HMF), diformyl furan (DFF), or a derivative thereof with a Grignard reagent,under conditions sufficient to form the diol.8. The method of claim 7 , wherein the Grignard reagent is RMgCl claim 7 , wherein R is H claim 7 , C-Calkyl claim 7 , C-Calkenyl claim 7 , aryl claim 7 , or C-Calkyl-aryl.9. (canceled)12. The diglycidyl ether of claim 11 , wherein Ris methyl or phenyl.14. The diglycidyl ether of claim 13 , wherein Rand Rare both methyl claim 13 , n-butyl claim 13 , or allyl.18. A curable coating composition comprising claim 13 , consisting essentially of claim 13 , or consisting of:{'claim-ref': {'@idref': 'CLM-00010', 'claim 10'}, 'a) at least one diglycidyl ether of ; and'}b) an amine.19. The curable coating composition of claim 18 , wherein the amine is an aliphatic claim 18 , an aromatic claim 18 , a cycloaliphatic claim 18 , or a polyether amine.20. The curable coating composition of claim 19 , wherein the aliphatic amine is Priamine 1075 claim 19 , 1 claim 19 ,8-diaminooctane claim 19 , diethylenetriamine claim 19 , or tetraethylenepentamine.21. The curable coating composition of claim 19 , wherein the aromatic amine is m-xylylenediamine.22. The curable coating composition of claim 19 , wherein ...

拟除虫菊酯化合物及应用

本发明涉及一种拟除虫菊酯化合物，以及这几种化合物的制备方法及其在卫生杀虫产品中的应用。其通式为(A)，式中R 1 为甲基、甲氧基甲基(-CH 2 OCH 3 )或者H原子，R 2 为-CF 3 或-COOCH(CF 3 ) 2 。实验表明，通式为(A)的化合物对蚊、蝇、德国小蠊等卫生害虫有很好的防治效果。

Analysis for optical purity of alcohol, thiol and amine, and method for preparing high-purity chiral alcohol, thiol and amine

본 발명은 키랄 시클로프로판 카르복시산 유도체를 사용하여 거울상 이성질체 혼합물의 광학 순도를 분석하고 이로부터 고순도의 키랄 화합물을 제조하는 방법에 관한 것으로, 키랄 시클로프로판 카르복시산 유도체를 거울상 이성질체 혼합물 상태의 알코올, 티올 또는 아민과 반응시켜 각각의 부분입체 이성질체 혼합물 상태의 에스테르, 아미드 또는 티오에스테르로 변환시키는 단계를 포함한다. The present invention relates to a method for analyzing the optical purity of an enantiomeric mixture using chiral cyclopropane carboxylic acid derivatives and to prepare a high purity chiral compound therefrom. Reacting with and converting into esters, amides or thioesters in the respective diastereomeric mixture.

A composition for the treatment or prevention of pneumonia comprising Hexanedioic acid

본 발명에서 헥산디올산(Hexanedioic acid)이 폐렴간균의 생육저해작용을 유발함으로써 폐렴간균에 대한 항균활성 또는 항균효과를 가지고 있음이 확인되었으며 이를 활용한 폐렴의 치료, 개선 또는 예방을 위한 조성물로 사용될 수 있음을 확인하였다. 본 발명은 헥산디올산(Hexanedioic acid)을 유효성분으로 포함하는 폐렴의 치료 또는 예방용 약학적 조성물, 예방 또는 개선용 건강식품 조성물, 예방 또는 개선용 사료 조성물에 관한 것이다. 본 발명에 따른 약학적 조성물, 건강식품 조성물 및 사료 조성물은 폐렴간균의 성장 및 분열증식을 억제하고 생육저해작용을 유발함으로써 폐렴의 치료, 개선 또는 예방용 항균제로 유용하게 사용될 수 있다. In the present invention, hexane diol acid (Hexanedioic acid) has been shown to have antimicrobial activity or antimicrobial effect against pneumococcus by inducing the growth inhibition effect of pneumococcal bacilli, and as a composition for treating, improving or preventing pneumonia using the same Respectively. The present invention relates to a pharmaceutical composition for the treatment or prevention of pneumonia comprising hexane diol acid (Hexanedioic acid) as an active ingredient, a health food composition for prevention or improvement, and a feed composition for prevention or improvement. The pharmaceutical compositions, health food compositions and feed compositions according to the present invention can be effectively used as antimicrobial agents for treating, ameliorating or preventing pneumonia by inhibiting growth and proliferation of pneumococcal bacilli and inducing growth inhibition.

一种利用5-羟甲基糠醛选择性加氢制备2，5-呋喃二甲醇的方法

本发明公开了一种利用5‑羟甲基糠醛选择性加氢制备2，5‑呋喃二甲醇的方法，将5‑羟甲基糠醛、催化剂CuNPs@ZIF‑8和乙醇加入不锈钢密闭反应器中，充入H 2 ，于120‑150℃的温度并1‑4MPa的压力下反应0.1‑5h。本发明以CuNPs@ZIF‑8为催化剂，该催化剂不仅比表面积大、纳米铜分散度高和氢气吸附性能好而且制备简单，价格廉价且可重复利用。本发明克服了现有研究中使用贵金属为催化剂价格昂贵和非贵金属为催化剂效率低的难题。

Method for producing cyclopropilcarbonic acids

Изобретение относится к органической химии, конкретно к получению циклопропилкарбоновых кислот, производные которых находят применение в качестве пластификаторов и поверхностно-активных веществ. Способ заключается в том, что проводят окисление олефинов циклопропанового ряда в смеси с гидроксидом натрия, метанолом и хлористым метиленом, озоном при температуре -50°С. Технический результат - увеличение выхода целевого продукта при повышении его качества. 1 з.п. ф-лы, 1 табл., 2 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 620 268 C1 (51) МПК C07C 51/34 (2006.01) C07C 61/15 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ 2016113879, 11.04.2016 (24) Дата начала отсчета срока действия патента: 11.04.2016 Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 11.04.2016 (45) Опубликовано: 24.05.2017 Бюл. № 15 (56) Список документов, цитированных в отчете о поиске: US 3462453 A, 19.08.1969. US C 1 (57) Формула изобретения 1. Способ получения циклопропилкарбоновых кислот окислением олефинов циклопропанового ряда в смеси с гидроксидом натрия, метанолом и хлористым метиленом, озоном при температуре -50°С. 2. Способ по п. 1, отличающийся тем, что процесс озонирования проводят при следующем соотношении компонентов, мас.%: 1,1-дихлор-2-винил-2-циклопропан 1; гидроксид натрия 1,6; метанол 12,6; хлористый метилен 84,8. R U 2 6 2 0 2 6 8 (54) Способ получения циклопропилкарбоновых кислот Стр.: 1 C 1 3341611 A, 12.09.1967. US 2002/0169329 A1, 14.11.2002. Арбузова Т.В. "Синтез замещенных гем.-дихлорциклопропанов и реакции их основе" Диссертация на соискание ученой степени кандидата химических наук, Уфа, 2006, 111с. 2 6 2 0 2 6 8 Адрес для переписки: 450062, г. Уфа, ул. Космонавтов, 1, Уфимский государственный нефтяной технический университет, патентный отдел (73) Патентообладатель(и): Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уфимский ...

Pyrethroid insecticide for protecting plants and seed

The present invention relates to pyrethroid insecticides and the stereoisomers thereof and to compositions comprising the same. The invention also relates to the use of the insecticides or compositions comprising such insecticides for combating invertebrate pests. Furthermore, the invention relates to methods of applying such insecticides.

Method of obtaining ranitidin or its hydrochloride

Ranitidine, which has the formula <CHEM> is prepared by reaction of N-[2-[[[5-(hydroxymethyl)-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nit ro-1,1-eth enediamine, which has the formula <CHEM> in an organic solvent, e.g. dimethylformamide, with dimethylamine and an N,N-(dimethylamino)-triphosphoniumhalide having the formula (C6H5)3 @NMe2, Hal<-> wherein Hal denotes bromo or chloro. The starting material (V) can be prepared in good yield and few reaction steps from known and readily available materials, and the overall synthesis of ranitidine therefore can take place from readily available raw materils in technically simple reaction steps and it gives a good yield of ranitidine in high purity without using complicated purification methods. The invention also relates to the compound (V), which is novel, and the direct starting compound for the preparation of (V), viz. N-[2-[[[5-(hydroxymethyl)-2-furanyl]methyl]thio]ethyl]-1-methylthio-2- nitroethen eamine having the formula (IV) <CHEM> s

Insecticide

Insecticidal preparation in the form of emulsifiable concentrate

1. Fluoroalkenyl-substituted cyclopropane compounds of the formula (I) see diagramm : EP0009709,P11,F1 in which R**1 represents chlorine, R**2 represents chlorine, R**3 represents Cl or Br, X represents see diagramm : EP0009709,P11,F2 and R represents C1-4 -alkyl and the radicals of the formula see diagramm : EP0009709,P11,F3 or in the case where R**3 represents Cl, represents see diagramm : EP0009709,P11,F4

The method of obtaining substituted esters of chrysanthemum acid

The seperation method of alpha-halo alkanoic acid optical isomers composition

A method for the separation of a recemic mixture of alpha- haloalkanoic acid comprises reacting a metal salt of a cpd. of formula (II) with a cpd. of formula (III) to obtain a pair of diastereoisomers of formula (IV), separating the diastereoisomers by column chromatography, esterifying the obtd. cpd., and reducing the optically pure cpd. of formula (V). In the formulas, R=C1-10 alkyl or C6-12 aryl; X=Cl, Br or I; R1=C1-10 alkyl or C6-12 aryl; R2=H, C1-10 alkyl or C6-12 aryl. The optically pure alpha- haloalkanoic acids are useful as intermediates in the mfr. of medicines or agricultural chemicals.

Process for the preparation of 2,4-dibromo-5-fluorobenroicacid

A process for preparing 2,4-dibromo-5-fluorobenzoic acid of formula (I) comprises (A) obtaining 2,4-dibromo-5-fluorotoluene (II) 3- fluorotoluene (B) reacting (II) with Br2 in the presence of UV to form 3-fluoro-alpha, alpha, 4,5-tetrabromotoluene (IV) (C) hydrolyzing (IV) and reacting with Jones reagent to obtain (I). (I) is an intermediate in the synthesis of a potent antibacterial compound.

Preparation method and application of sulfonic acid functionalized inorganic-organic hybrid polymer catalyst

本发明公开了一种磺酸功能化无机有机杂化聚合物催化剂的制备方法，该方法过程简单，操作方便，不需要精密昂贵的特定设备，制备的催化剂没有贵金属的参与且同时含有Lewis酸性位点/Lewis碱性位点和Brϕnsted酸性位点等多个催化位点，具备良好的催化活性和成本优势。另外，该方法制备得到的催化剂可以以廉价易得的低碳醇同时作为原位氢供体、醚化反应物和反应介质，通过分步调温法将5‑羟甲基糠醛连续还原醚化转化为相应的2,5‑二烷氧基甲基呋喃，整个反应过程不需要额外添加外源氢供体和其他反应溶剂，反应体系组成安全简单，有利于目标产物的分离。更加重要的是，本发明提出的分步调温法可以让催化剂的Lewis酸性位点/Lewis碱性位点和Brϕnsted酸性位点分别在合适的温度下发挥催化作用，使中间产物和目标产物能够分步连续生成，既可以避免其他副产物的形成，也有利于提高中间产物和目标产物的选择性和得率。

(10) 2,3,5,6-tetrafluorobenzyl 1R-trans-2,2-dimethyl-3- (2,2-dichlorovinyl) -cyclopropanecarboxylate

The method of obtaining cyclopropanecarboxylate

Pyrethroid compounds and use thereof

Disclosed are pyrethroid compounds represented by formula (A), or their stereo chemical isomers, or the mixture of such isomers, and the preparation process thereof and the use thereof for killing pests. In the formula (A), R 1 is methoxymethyl (-CH 2 OCH 3 ) or H; and R 2 is –CF 3 or –COOCH(CF 3 ) 2 . The test proves that the present compounds show better effect for repelling and controlling pests such as mosquito, musca and German cockroach.

Pyrethroid compound, preparation process and use thereof

Disclosed are a pyrethroid compound, a preparation process and the use thereof, wherein the compound is a stereoisomer of 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl-3-(3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate. The structure of the compound is represented by formula (A), in which the carbon-carbon double bond in carboxylic acid section is Z configuration, and the absolute stereo configuration at the 1-position of cyclopropane is R, namely, the said compound is 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl-1R-(Z)-3-(3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate. The said pyrethroid compound has a high activity, and has a significant effect on preventing and curing sanitary pests.

Pesticidal ester compound

本发明提供一种具有杀虫活性的酯化合物，其结构如式(Ⅰ)或式(Ⅱ)所示。其中，Z1为氢原子、氰基、乙炔基或硝基；R1为氢原子、氰基、卤素原子、羟基、胺基、C1-C4烃基或卤代烃基、或基团－(CH 2 ) m -X-R1'，其中m＝0或1，X为氧原子或硫原子，R1'为C1-C4烃基或卤代烃基；X1为氰基、一氟甲基、二氟甲基、C2-C4的不饱和烃基或卤代烃基；Z2为氢原子、氰基、乙炔基或硝基；n为1-4的整数；R2为氰基、卤素原子、羟基、硝基、胺基、卤代甲基、C2-C4烃基或卤代烃基、或基团-(CH 2 ) q -X2-R2'，其中q＝0或1，X2为氧原子或硫原子，R2'为卤代甲基、C2-C4烃基或卤代烃基。该化合物具有优异的杀灭害虫的活性，可用作害虫防治剂的有效成分。本发明还提供所述化合物的制备方法和在防治害虫方面的应用。

Ester compounds and use thereof

提供一種具有優良的有害生物防除效力的化合物。 一種酯化合物及使用該酯化合物之有害生物防除劑及有害生物防除方法，以下列的通式[化1](I)表示： [式中R 1 是表示氫原子或甲基，R 1 表示甲基時R 2 也表示甲基，而且R 1 表示氫原子時R 2 為以下列通式[化2](II) (此處X及Y為同一或不同，表示氫原子、鹵素原子、氰基、碳數1~4的烷基、碳數2~5的烷氧基羰基或碳數1~4的鹵烷基)表示的基，R 3 是表示氫原子、三氟甲基、甲基、甲氧基、甲氧基甲基、烯丙基、乙炔基或丙炔基，R 4 表示氟原子時R 5 表示碳數1~4的烷基，或者R 4 表示碳數1~4的烷基時R 5 表示與R 4 同一的取代基]。

Pyrethroid compounds and use thereof

Disclosed are pyrethroid compounds represented by formula (A), or their stereo chemical isomers, or the mixture of such isomers, and the preparation process thereof and the use thereof for killing pests. In the formula (A), R 1 is methoxymethyl (-CH 2 OCH 3 ) or H; and R 2 is -CF 3 or -COOCH(CF 3 ) 2 . The test proves that the present compounds show better effect for repelling and controlling pests such as mosquito, musca and German cockroach.

Patent JPS4947531A

Method of feeding animals and poultry

FIELD: agriculture. SUBSTANCE: invention relates to fodder production, and can be used in poultry and livestock farming as additive to diet for feeding animals and birds. Method of feeding, which includes giving feed with stabilizing additive. Antioxidant "Bisphenol-5" is used as stabilizing additive, which is introduced into compound feed in concentration of 0.00019-0.00152% by weight. EFFECT: implementation of invention provides for increasing meat production, improving quality of meat and increasing growth in live weight of animals and poultry. 1 cl, 8 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 654 095 C1 (51) МПК A23K 20/111 (2016.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A23K 20/111 (2006.01) (21)(22) Заявка: 2017105644, 20.02.2017 (24) Дата начала отсчета срока действия патента: Дата регистрации: 16.05.2018 (45) Опубликовано: 16.05.2018 Бюл. № 14 2 6 5 4 0 9 5 R U (56) Список документов, цитированных в отчете о поиске: RU 2376865 C1, 27.12.2009. СЕМИНА О.В., ГАРАЕВА Г.А., АХМАДУЛЛИН Р.М., ШИЛОВ В.Н. Влияние препарата Бисфенол-5 на ростовые процессы белых крыс. Сборник научных статей. Продовольственная самодостаточность региона в условиях импортозамещения: вопросы теории и практики. Казань: Общество с ограниченной ответственностью Издательскополиграфическая (см. прод.) (54) СПОСОБ КОРМЛЕНИЯ ЖИВОТНЫХ И ПТИЦЫ (57) Реферат: Изобретение относится к сельскому хозяйству, стабилизирующей добавки используют а именно к кормопроизводству, и может быть антиоксидант «Бисфенол-5», который вводят в использовано в птицеводстве и животноводстве комбикорм в концентрации 0,00019-0,00152% мас. в качестве добавки к рациону при кормлении Осуществление изобретения обеспечивает животных и птиц. Способ кормления, повышение мясной продуктивности, улучшение включающий дачу комбикорма со качества мяса и увеличение прироста живой массы стабилизирующей добавкой. В качестве животных и птицы. 8 табл., 4 пр. (56) ( ...

1-methyl-2-chlorocyclopropane carboxylic acid, ester thereof and manufacture

Insecticide composition

Insecticide

NOVEL DERIVATIVES OF 2,2-DIMETHYL 3- (2-FLUOROVINYL) CYCLOPROPANE CARBOXYLIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS PESTICIDES

Pyrethroid compounds and composition for controlling pest containing the same

Method of struggle against harmful insects

Использование: сельское хоз йство, химический способ борьбы с вредными насекомыми . Сущность: очаг поражени  насекомых обрабатывают соединени ми формулы I C(RiR2)C(CH3)2CHC(0)0 CH2C6F4CH20H), в которой кажда  из группы RI и R2 представл ет метил,либо когда RI - водород, R2  вл етс  группой СН-, где Ra и R4 - независимо друг от друга водород, галоген, метил, трифторметил, при дозе 0,001-0,1 кг/га. 5 табл., 6 пр.

The acid catalysis of 5 (methylol) furfural reduzates is acylated

描述了一种用于使用耐水性路易斯酸催化剂酸催化酰化的改进方法。该方法涉及在路易斯酸金属三氟甲磺酸盐的存在下，在足以产生酯的温度和时间下，使5‑(羟甲基)‑糠醛(HMF)的还原产物、特别是或者呋喃‑2,5‑二甲醇(FDM)或双‑2,5‑(羟甲基)‑四氢呋喃(bHMTHF)与过量的有机酸反应。所述HMF还原产物到相应二酯的转化在某些有利的路易斯酸催化剂情况下可以是定量的。

Liquid crystal compounds, and a LCP mixture, a LCP network and an optical or electro-optical device comprising the same

화학식 Ⅰ의 화합물. Compound of Formula (I). 화학식 Ⅰ Formula I 위의 화학식 Ⅰ에서, In Formula I above, G 1 및 G 2 는 독립적으로 중합 가능한 메소제닉(mesogenic) 잔기를 나타내고, G 1 and G 2 independently represent a mesogenic moiety that is polymerizable, X는 -CH 2 -, -O-, -CO-, -COO-, -OOC-, -CONR'-(여기서, R'는 수소, 저급 알킬 그룹 또는 저급 알케닐 그룹을 나타낸다), -OCOO- 및 -OCONR'-(여기서, R'는 위에서 정의한 바와 같다)로 이루어진 그룹으로부터 선택된 그룹을 나타내며, X is -CH 2- , -O-, -CO-, -COO-, -OOC-, -CONR'- (where R 'represents hydrogen, lower alkyl group or lower alkenyl group), -OCOO- And -OCONR'-, wherein R 'is as defined above. Sp는 화학식 -(CH 2 ) p -의 그룹[여기서, p는 1 내지 18의 정수이고, 1 또는 2개의 인접하지 않은 -CH 2 - 그룹은 -CH=CH-로 치환될 수 있거나, 1 또는 2개의 -CH 2 - 그룹은 -CH 2 -, -O-, -CO-, -COO-, -OOC-, -CONR'-(여기서, R'는 위에서 정의한 바와 같다), -OCOO- 및 -OCONR'-(여기서, R'는 위에서 정의한 바와 같다)로 이루어진 그룹으로부터 선택된 1 또는 2개의 그룹으로 치환될 수 있다]을 나타내고, 단 당해 스페이서 그룹은 2개의 인접한 헤테로원자를 함유하지 않으며, X가 -CH 2 -인 경우, p는 0의 값을 가질 수 있으며, Sp is a group of the formula-(CH 2 ) p -wherein p is an integer from 1 to 18, and one or two non-adjacent -CH 2 -groups can be substituted with -CH = CH-, or 1 or The two -CH 2 -groups are -CH 2- , -O-, -CO-, -COO-, -OOC-, -CONR'- (where R 'is as defined above), -OCOO- and- OCONR'-, wherein R 'may be substituted with one or two groups selected from the group consisting of above, provided that the spacer group does not contain two adjacent heteroatoms and X is In the case of -CH 2- , p may have a value of 0, Q는 -CN, -COR(여기서, R은 수소, 저급 알킬 그룹, 저급 알케닐 그룹, 또는 아래에서 정의하는 바와 같은 사이클릭 그룹을 나타낸다), -COOR(여기서, R은 위에서 정의한 바와 같다), -OCOR(여기서, R은 위에서 정의한 바와 같다), -CONR'R(여기서, R' 및 R은 위에서 정의한 바와 같다), -NR'COR(여기서, R' 및 R은 위에서 정의한 바와 같다), -OCOOR(여기서, R은 위에서 정의한 바와 같다), -OCONR'R(여기서, R' 및 R은 위에서 정의한 바와 같다), -NR'COOR(여기서, R' 및 R은 위에서 정의한 바와 같다), F, Cl, -CF 3 , -OCF 3 및 -OR로 이루어진 그룹으로부터 선택된 극성 그룹을 나타내거나, 치환되지 않거나 저급 알킬 그룹, 저급 알케닐 그룹, 저급 알콕시 그룹, 저급 알케닐옥시 그룹, 할로겐, -CN, -COR"(여기서, R"는 저급 알킬 그룹 또는 저급 알케닐 그룹을 나타낸다), ...

Method of producing furfurol acetals, which are an antiknock additive of automotive fuels, and a fuel composition containing an additive

FIELD: technological processes. SUBSTANCE: invention relates to a method of producing furfurol products, specifically a method of producing furfurol acetals. Disclosed method is carried out by reacting furfurol and aliphatic monohydric alcohols C 1 -C 3 , in the presence of a sulfocationite catalyst of a macroporous and / or gel structure in molar ratio furfurol : alcohol C 1 -C 3 = 1:6–10 and at temperature range of 0–30 °C without water removal from system. Invention also relates to a composition of automotive fuel from hydrocarbon fractions containing an antiknock additive produced according to the developed method in concentration of 1.0–15.0 wt%. EFFECT: novel method of producing furfurol acetals with high conversion and output, which are an antiknock additive and can be used in automotive fuels to increase their detonation resistance and improve lubricating power. 3 cl, 3 tbl, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 704 035 C1 (51) МПК C07D 317/08 (2006.01) C07D 307/42 (2006.01) C07D 307/34 (2006.01) B01J 23/14 (2006.01) C10L 1/18 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07D 317/08 (2019.05); C07D 307/42 (2019.05); C07D 307/34 (2019.05); B01J 23/14 (2019.05); C10L 1/18 (2019.05) (21)(22) Заявка: 2018146839, 27.12.2018 27.12.2018 Дата регистрации: 23.10.2019 (45) Опубликовано: 23.10.2019 Бюл. № 30 2 7 0 4 0 3 5 R U (56) Список документов, цитированных в отчете о поиске: ЗЕЛИКМАН З.И. Известия высших учебных заведений. Пищевая технология, 5 (60), 1967, стр. 116-118. WO 2010011156 A1, 28.01.2010. SU 1384588 A1, 30.03.1988. SU 1307775 A1, 20.02.2000. US 6890364 B2, 10.05.2005. (54) СПОСОБ ПОЛУЧЕНИЯ АЦЕТАЛЕЙ ФУРФУРОЛА, ЯВЛЯЮЩИХСЯ АНТИДЕТОНАЦИОННОЙ ДОБАВКОЙ АВТОМОБИЛЬНЫХ ТОПЛИВ, И ТОПЛИВНАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ДОБАВКУ (57) Реферат: Изобретение относится к способу получения из углеводородных фракций, содержащей продуктов переработки фурфурола, а именно к антидетонационную добавку, полученную ...

Method of preparing esters of cyclopropanecarboxylic acids

Plant growth inhibitor

Insecticidic and acaricidic agent

Attractants for the Mediterranean fruit fly

Novel attractants for the Mediterrean Fruit fly, "Medfly" comprise isomeric blends of C l -C₅ alkyl esters of iodo- trans -2-methylcyclohexanecarboxylic acid.

Method for producing ester compound

有機溶媒中で2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボン酸メチルと[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メタノールとをリチウムメトキシドの存在下に反応させて[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メチル　2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボキシラートを製造する上で、有機溶媒、2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボン酸メチル及び[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メタノールの混合物を亜硫酸水素塩水溶液で洗浄した後、リチウムメトキシドを加えて反応を行うことにより、不純物の生成を抑制して目的物を製造することができる。

Patent FR2300559B1

NOVEL ESTERS OF 3- (3,3,3-TRIFLUORO 2-CHLORO PROPENYL) 2,2-DIMETHYL CYCLOPROPANECARBONECARBOXYLIC ACID, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES.

L'invention a pour objet, sous toutes les formes stéréoisomères possibles ainsi que leurs mélanges, les composés répondant à la formule générale (I): (CF DESSIN DANS BOPI) dans laquelle: Z représente un atome d'hydrogène, un radical CH3 , un radical CcongN, ou un radical CcongCH, et R représente un radical phényle substitué choisi dans le groupe constitué par les radicaux: (CF DESSIN DANS BOPI) Les composés de l'invention présentent d'intéressantes propriétés pesticides.

Patent FR2218316B1

Patent FR2685320B1

Cyclopropane carboxylic acids as insecti - cides

New bisubstituted acetylenic alcohols and process for their production

Veterinary antiviral emulsions of terpene alcohols

Veterinary antiviral and antineoplastic emulsions for adding to the drinking water of poultry comprise an aqs. emulsion of geraniol, nerol, linalol, citronellol or undecylenic alcohols such that each bird receives a daily dose of 1 mg. The continuous administration of the drug throughout the day gives a higher cure rate compared with a single dose of the same amount of drug.

FOOD PREPARATIONS COMPRISING SALBUTAMOL, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF TO IMPROVE THE RATE OR SPEED OF GROWTH IN ANIMALS.

ON UTILISE LE SALBUTAMOL ET DES SELS D'ADDITION D'ACIDES DE CE DERNIER POUR AUGMENTER LA VITESSE DE CROISSANCE ETOU LE RAPPORT VIANDE A GRAISSE CHEZ DES ANIMAUX DOMESTIQUES FAISANT PARTIE DU CHEPTEL VIF SANS PROVOQUER DE POLYPHAGIE. ON PEUT ADMINISTRER LE SALBUTAMOL PAR LA VOIE ORALE, PAR EXEMPLE EN MELANGE A DES PRODUITS ALIMENTAIRES EN UNE CONCENTRATION QUI VARIE DE 2 A 12 PPM. LE PROCEDE CONVIENT TOUT PARTICULIEREMENT A L'ELEVAGE DE PORCS. SALBUTAMOL AND ACID ADDITIONAL SALTS OF THE LATTER ARE USED TO INCREASE THE GROWTH RATE AND OR THE MEAT-TO-FAT RATIO IN DOMESTIC ANIMALS PART OF THE LIVING HERD WITHOUT CAUSING POLYPHAGY. SALBUTAMOL CAN BE GIVEN BY THE ORAL ROUTE, FOR EXAMPLE AS A MIXTURE WITH FOOD PRODUCTS IN A CONCENTRATION WHICH RANGES FROM 2 TO 12 PPM. THE PROCESS IS PARTICULARLY SUITABLE FOR BREEDING PIGS.

NOVEL DERIVATIVES OF 2,2-DIMETHYL ACID 3 - [(2,2-DIFLUOROCYCLOPROPYLIDENE METHYL] CYCLOPROPANE CARBOXYLIC, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES.

Patent FR2345423B1

1,2,3,4-Tetrahydro 4-oxo or 4-hydroxy 1-naphthyl (thio)urea derivs. - animal growth promoters administered with feed or as implant

Tetrahydronaphthylureas of formula (I), their racemic mixture, cis and trans isomers and when U = CHOR6 their optical isomers, are novel cpds. (where X = O or S; U = R1,R2 independently = H or 1-4C alkyl; R3 = H, 1-4C alkyl, 3-5C alkynyl, 3-5C alkenyl, 1-4C alkoxy, benzyl or benzyloxy; R4 = H, 1-4C alkyl or 1-4C alkoxy; R5 = H or 1-4C alkyl; R6 = H, 1-4C alkyl or 1-4C acyl. The cpds. are useful as animal growth promoters which may be administered with feed at levels of 0.001-0.08 wt. % (pref. 0.001-0.04 wt. %), as implants which release daily 0.0005-0.5 mg/kg (pref. 0.001-0.2 mg/kg) or by sub-cutaneous or intramuscular injection. The (S) isomers generally have superior activity to the (R) isomers.

Patent FR2297834B3

N-(hydroxyalkyl) aliphatic amide compsns -animal - feedstuff additives

Compsns contain 0.002-1.0 wt % (pref. 0.02-0.1 wt %) of RCONHX (where R = 3-21C (pref. 7-13C) aliphatic radical and X = 1-3C hydroxyalkyl), and give improved weight gained to food consumed ratio.

PYRETHROID COMPOUNDS USEFUL AS INSECTICIDES AND PROCESS FOR THEIR PREPARATION

Patent FR2687665B1

Process for the preparation of ranitidine or acid addition salts thereof

내용 없음. No content.

CYCLOPROPYL CARBOXYLATES PESTICIDES

Des cyclopropyl carboxylates ayant la formule générale : Cyclopropyl carboxylates having the general formula:

Fungicidal bactericidal cyclopropane carboxylic acid derivs. - are intermediates in prepn. of insecticidal, acaricidal, nematocidal and antifungal ester(s)

Cyclopropanecarboxylic acid derivs. of formula (I) and their functional derivs. are new. In (I), X1 is H, F, Cl or Br; X2 is F, Cl or Br; and X3 is Cl, Br or I. (I) have fungicidal properties and are partic. suitable for combatting phytopathogenic fungi, e.g. on vines, tomatoes and cucumbers. They also have bactericidal properties and can be used as industrial biocides. (I) and their functional derivs. are also useful as intermediates for esters of the acids (I) which have insecticidal, acaricidal, nematocidal and antifungal properties. Specific (I) is (1R-cis)-2,2-dimethyl-3-(1,2,2,2-tetrabromoethyl)-cyclopropane-1-- carboxylic acid.

Patent FR2486073B1

Patent FR2062871B1

Patent FR2188964B1

CARBOXYL DISPIROCYCLOPROPANE ESTERS WITH PESTICIDE PROPERTIES

Process for the preparation of new esters, active as insecticides, of the pyrethrin type

Patent FR2201036A1

NEW DERIVATIVES OF 4,5 BENZOSPIRO (2,4) HEPTANE-1-CARBOXYLIC ACID USEFUL FOR CONTROLLING PARASITES

Patent FR2482955B1

Patent FR2218316A1

Patent FR2398714B1

2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity

Cpds. of formula (I): where R1 = H, 1-3C alkyl, isobutyl, tert-butyl, 4-8C cycloalkyl, 3-4C alkenyl in which the double bond is sepd. from the N atom by >=1C atom, phenyl, 8-10C phenylalkyl in which the phenyl ring may be halo substd., 2-4C alkanoyl, benzoyl (opt. substd. by =2 haloatoms, methyl or methoxy), 8-10C phenylalkanoyl (the phenyl ring opt. substd. by halo), pyridylcarbonyl or thienylcarbonyl. In the cases where R1 = H, alkyl, cycloalkyl, alkenyl, phenyl, or opt. substd. phenylalkyl the acid addition salts are also claimed. Specif. claimed is (I) where R1 = (4-chlorophenyl)-ethyl, benzoyl, 4-chlorobenzoyl and 3-chlorobenzoyl. (I) are analgesics some of which also have antiinflammatory activity. They are administered orally (unit doses of 50-500 mg), parenterally (0.5-5 wt. % soln.) or rectally opt. with other active cpds., e.g. analgesics, neuroleptics, sedatives or tranquilizers. The maximum sub-lethal dose of I (R1=benzoyl) in rats is 316 mg/kg by intraperitoneal injection and 1000 mg/kg by oral administration.

Patent FR2539956B2

NEW ESTERS OF CYCLOPROPANE CARBOXYLIC ACIDS CONTAINING A POLYHALOGENIC SUBSTITUTE, PREPARATION PROCESS AND INSECTICIDE COMPOSITIONS CONTAINING THEM

La présente addition a pour objet d'illustrer par de nouveaux exemples la formule générale du brevet principaL Les composés des nouveaux exemples ont pour formule générale : The object of the present addition is to illustrate by new examples the general formula of the main patent. The compounds of the new examples have the general formula:

NEW PROCESS FOR PREPARATION OF CHRYSANTHEMIC ACID ESTERS

3-(1-phenylethenyl) benzyl alcohol derivatives and its process

3-(1-Phenylethenyl) benzylalcohol derivs. of formula (I) are prepd. by (a) reacting 3-(1-phenylethenyl) benzylalcohol of formula (II) with p-toluene sulfonyl chloride to obain benzyltoluene sulfonate, and (b) reacting it with 2- (4-ethoxyphenyl)-2-methyl propanol. In the formulas, R = a gp. of formula (III); A = -CH[CH(CH3)2 -CO- or -(CH3)2-CH2-; R3 = Cl or C1-3 lower alkoxy. Cpds. (I) have a good insecticidal activity.

COMPOSITION FOR LIMITING THE CONSUMPTION OF A FEED SUPPLEMENT BY LIVESTOCK, AND ITS APPLICATION TO THE FREE FEEDING OF THIS LIVESTOCK

L'INVENTION CONCERNE UNE COMPOSITION POUR LIMITER LA CONSOMMATION D'UN COMPLEMENT ALIMENTAIRE PAR DU BETAIL. LA COMPOSITION COMPREND AU MOINS UN COMPOSE DE FORMULE: CHA-CHB-CHC A: OH, R ; B: HALOGENE, OH, R; C: HALOGENE OU OH SI B EST UN HALOGENE OU SI B EST AUSSI OH ET A EST R; ET R: OR OU O-C(O)-R; DE PREFERENCE R: ALKYLE AYANT 9 A 18C. EN ASSOCIATION AVEC UN COMPLEMENT ALIMENTAIRE LIQUIDE OU AVEC DES COMPLEMENTS SOLIDES, LA COMPOSITION PERMET UNE ALIMENTATION LIBRE DU BETAIL (SUPPRIMANT L'OBLIGATION D'UNE FOURNITURE QUOTIDIENNE DE RATION ALIMENTAIRE, AINSI QUE LES RISQUES DE SURALIMENTATION). THE INVENTION RELATES TO A COMPOSITION FOR LIMITING THE CONSUMPTION OF A DIETARY SUPPLEMENT BY LIVESTOCK. THE COMPOSITION CONSISTS OF AT LEAST ONE COMPOUND OF THE FORMULA: CHA-CHB-CHC A: OH, R; B: HALOGEN, OH, R; C: HALOGEN OR OH IF B IS A HALOGEN OR IF B IS ALSO OH AND A IS R; AND R: OR OR O-C (O) -R; PREFERREDLY R: ALKYL HAVING 9 TO 18C. IN ASSOCIATION WITH A LIQUID FOOD SUPPLEMENT OR WITH SOLID SUPPLEMENTS, THE COMPOSITION ALLOWS A FREE FEEDING OF THE LIVESTOCK (REMOVING THE OBLIGATION OF A DAILY SUPPLY OF FOOD RATION, AS WELL AS THE RISK OF OVER-FEEDING).