Способ искусственной вентиляции легких при протезировании бифуркации трахеи

Изобретение относится к медицине, а именно к анестезиологии, и может быть использовано при протезировании бифуркации трахеи. Цель - снижение частоты интра- и послеоперационных осложнений путем непрерывной вентиляции легких в процессе протезирования бифуркации трахеи. При формировании анастомоза протеза с культей бронха инсуфляционный катетер извлекают и возвращают через интубационную трубку, трахею, протез. Способ позволяет поддерживать постоянную вентиляцию.легких в процессе протезирования. Способ рекомендован в практику. 1 табл. Ј ...

Vorrichtung zur UEbertragung einer biologischen Substanz in das Hautgewebe

MIKROVORSPRÜNGE ZUM DURCHSTECHEN DER HAUT MIT STECHTIEFENSTEUERUNG

Mit einem Ventil versehenes intradermales Verabreichungsgerät

Ritzgeraet fuer Impfungen

Skin lancet for tissue compatibility tests - has set of spring loaded lancet blades in holder released by trigger

The skin lancer used to puncture the skin in a uniform pattern for allergy or tissue compatibility tests has perpendicularly sliding, spring loaded (6) lancer blades (3) arranged in the support surface (4) of a guide (1) which is pressed onto or adhered to the skin. The lancers are fixed vertically in place in a withdrawn position by holders (10) with a release device which releases the blades to rapidly extend and project out over the support surface (4). Pref. the spring loaded lancers are shaped as flat blades and are provided with recessed areas or shoulders (5) with which they support themselves against the notched, vertically sliding plate or bar (10) which serves as a holder as well as a release device.

VERFAHREN ZUR BEHANDLUNG VON ALLERGISCHEN LUNGENKRANKHEITEN

CHIRURGISCHES INSTRUMENT

Improvements in and connected with Vaccine Tubes.

... 13,469. Darke, E. T. June 3. Vaccination appliances.-A combined vaccinetube and scarifier comprises a glass tube a charged with lymph d and with a steel wire scarifier c partly inserted therein and sealed with paraffin b. The tube is nicked at f and the sealed end e allowed to drop to one side so as to indicate the position of the nick. The point of the scarifier is ground sharp by three flats. For use, the tube is broken and the wire pushed through to expel the lymph and then further projected so as to serve for scratching the skin beneath the lymph.

Skin allergy test assembly

Multiple puncture apparatus

A surgical multiple puncture device for administering to a patient chemicals or biological material for therapeutic or diagnostic purposes. A barrier 9 of flexible plastics material is arranged between an operating plunger 6 and a needle plate 8. The barrier 9 is of frusto-conical dish shape with an outwardly directed flange 3 at its periphery. A semi-tubular portion 4, or a plurality of portions, is/are provided in the flange 3 to vent air between the interior of the barrier and the outside. The barrier may be located in complementary recesses in a pack of rigid or semi-rigid plastics material with needle plates arranged in the interiors of the barriers. ...

Drug delivery

SPONGE

Generating apparatus of solid aerosols of particles, in particular of aerosols inhalables of vaccines and containers being used as syringes adaptable to these apparatuses.

Device multipénétrant vaccinator.

DEVICES AND PROCEDURES FOR THE PRODUCTION OF HÄMATOPHAGEN ORGANISMS AND PARASITE FOR VACCINE PRODUCTION

INOCULATION EQUIPMENT

DEVICES FOR THE INTERSTITIAL INJECTION OF BIOLOGICAL ACTIVE SUBSTANCES IN FABRICS

MEDICAL DEVICE WITH A DECOUPLE-CASH MOUNTING PLATE

DEVICES FOR THE INTERSTITIAL INJECTION OF BIOLOGICAL MEANS IN FABRICS

BLISTERSTREIFEN

Die Erfindung betrifft einen Blisterstreifen welcher auf die Haut aufklebbar ist und aus zumindest zwei Folien gebildet ist und einen Applikator aufweist zum Applizieren eines im Blister enthaltenden Mediums auf oder in die Haut, wobei der Blisterstreifen eine obere Folie (2) umfasst, welche zumindest eine Ausstülpung (2.1) aufweist, wobei die die Ausstülpung (2.1) umgebende Unterseite (2.2) der oberen Folie (2) klebend ausgeführt ist und der Blisterstreifen eine untere Folie (3) aufweist, welche die untere Fläche des Blisterstreifens abdeckt und von der klebenden Unterseite (2.2) der oberen Folie (2) abgezogen werden kann. In der Ausstülpung (2.1) der oberen Folie (2) ist ein Applikator (1) eingesetzt, der die Ausstülpung (2.1) in zumindest zwei Teilvolumen trennt, wobei der Applikator (1) zumindest eine Öffnung (1.2) aufweist, welche zwei Teilvolumen verbindet, wobei ein Teilvolumen zwischen dem Applikator (1) und der unteren Folie (3) liegt und wobei zumindest ein Teilvolumen zur Gänze ...

SKIN TREATMENT DEVICE FOR EXTENDED TRANSDERMALEN THE ADMINISTRATION OF MEDICINES

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN ADMINISTRATION OF MEDICINES OR THE DECREASE OF BODY FLUIDS

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN DECREASE OF BODY FLUIDS

DEVICE FOR THE MANIPULATION OF NEEDLES OR POLISHING ARRAY

WITH A VALVE MISTAKE EQUIPMENT FOR INTRADERMALEN ADMINISTRATION

METHODS AND ACCESSORIES TO IMMUNISIERUNG OF LANDLORD ORGANISMS BY ADMINISTRATION THE NAKED ONE POLYNUCLEOTIDE, WHICH FOR ANTIGENS PEPTIDE CODING

MIKROKLINGEANORDUNGSAUFPRALLAPPLIKATOR

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN ADMINISTRATION OF MEDICINES OR THE DECREASE OF BODY FLUIDS

DEVICE FOR THE INCREASE THE TRANSDERMALEN OF THE ACTIVE SUBSTANCE RIVER

INJECTION UNIT

Packing for devices for Intradermal application

MEDICAL NEEDLE UNIT

APPLIKATOR ALSO ON SCHLEIFFENDE SURFACE COVERED SUBSTANCE FOR LAYING ON SKIN

Dna dosage forms

Surgical handpiece

Wound treatment method and device with combination of ultrasound and laser energy

Device to assist hyperhydrosis therapy

Ultrasonic method and apparatus for cosmetic and dermatological applications

MICRONEEDLE ARRAY PATCH

Antigen-adjuvant compositions and methods

Methods for localized intra-body treatment of tissue

Vaccines

Ultrasonic surgical instrument and cartilage and bone shaping blades therefor

Irrigation coupling apparatus and method

Self-actuating applicator for microprojection array

"Method of controlling a surgical system based on a rate of change of an operating parameter"

METHODS AND APPARATUSES FOR FORMING MICROPROJECTION ARRAYS

Miniature implantable illuminator for photodynamic therapy

Microstructure array for delivery of active agents

Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.

Microprojection array applicator and method

The present invention relates to applicators for administering microprojection arrays to skin and methods of administering microprojection arrays. One embodiment of the present invention is a device for applying a microprojection array to a skin surface comprising: a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face has a flexible section that when collapsed actuates the device; b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward; c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide; d) a microprojection array that is contacted by the cantilevered ring when the ring is activated; e) a skin contact membrane; and f) a skin contact applicator ...

Vaccines having an antigen and interleukin-21 as an adjuvant

Disclosed herein is a vaccine comprising an antigen and IL-21. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

Methods and devices for delivering agents across biological barriers

Abstract The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the 5 nicroneedles, themselves.

Parenterally administered medicament

Medical needle assemblies

Device and method for applying an active ingredient to the skin

An injection unit

AGENTS AND METHODS FOR ENHANCEMENT OF TRANSDERMAL TRANSPORT

The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.

METHOD AND APPARATUS FOR REDUCING THE INCIDENCE OF TOBACCO USE

ULTRASONIC WOUND DEBRIDER PROBE AND METHOD OF USE

An ultrasonic medical probe comprises an elongate shaft formed integrally with a head portion having a distal end face oriented at least partially transversely to a longitudinal axis of the shaft. The shaft is provided with an internal longitudinal channel or bore extending to the end face. The end face is fo.pi.ned with an indentation communicating with the channel or bore at a distal end thereof, whereby liquid is guided over an extended surface of the end face relative to the channel or bore. The head portion also has a lateral surface extending substantially parallel to the longitudinal axis of the probe. The lateral surface is provided with at least one outwardly or radially extending projection. The projection enables the application of ultrasonic cavitation energy to a tissue surface that is in contact with the lateral or side surface of the probe head.

APPARATUS FOR MICROPORATION OF BIOLOGICAL MEMBRANES USING THIN FILM TISSUE INTERFACE DEVICES, AND METHOD THEREFOR

The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.

TATTOOING APPARATUS

A tattooing apparatus is provided with at least one needle carrier with an arrangement of needles by which means at least a number of the needles are mutually arranged according to a program of symbols and in such a manner that the tissue to be tattooed can be pierced by the free ends of the needles. Each of the needles is hollow and is provided with an outlet opening close to its free end for feeding a contrasting fluid into the perforation in the tissue. The apparatus is further provided with fluid feeding means and control means therefor, the fluid feeding means comprising a reservoir accommodating contrasting fluid and a program carrier of non-porous material, the program carrier also including perforations which are directed in relation to the inlet openings of the needles.

DEVICE AND METHOD FOR DELIVERING OR WITHDRAWING A SUBSTANCE THROUGH THE SKIN

An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device (10) includes a body (12) having a top face (20), a bottom face (18), a side edge (16) and at least one channel (22). The bottom face (18) includes a first surface area (28) and a second surface area (30) adjacent to and recessed at a first distance from the first surface area (28). The bottom face (18) further includes at least one raised protrusion (32) disposed on the second surface area (30). The protrusion (32) has a height from the first surface (28) greater than the first distance. At least one dermal-access member (14) is provided in the protrusion (32) and is in fluid communication with the channel (22) to deliver or withdraw the fluid. The dermal-access member (14) extends at least 1 mm from the protrusion (32). A mechanism drives the device (10) against the skin at a calculated speed of about 6 m/s to about 18 m/s.

APPLICATOR HAVING ABRADING SURFACE COATED WITH SUBSTANCE TO BE APPLIED TO SKIN

The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.

MULTIPENETRANT VACCINATION APPARATUS

INSERTION SETS WITH MICRO-PIERCING MEMBERS FOR USE WITH MEDICAL DEVICES AND METHODS OF USING THE SAME

... ▓▓▓An insertion set for essentially painless insertion through tissue includes a ▓substrate and at least one micro-piercing member. The at least one micro-▓piercing member is coupled to the substrate to form a patch. In addition, the ▓at least one micro-piercing member has a predetermined length to pierce the ▓material to a predetermined depth to interact with the tissue. In particular ▓embodiments, the insertion set also includes a control structure within the ▓insertion set for controlling the flow of fluid relative to the substrate and ▓the at least one micro-piercing member of the insertion set. In addition, the ▓insertion set may include or utilize methods or structures for maintaining the ▓insertion set on the tissue for a predetermined period of time. Preferably, ▓the predetermined length of the at least one micro-piercing member is long ▓enough to pierce the tissue, and yet short enough to avoid contacting the ▓nerves in the tissue. The insertion set may also include a light controlling ...

MICROBLADE ARRAY IMPACT APPLICATOR

An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44, 90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.

MICROPROTRUSION MEMBER RETAINER FOR IMPACT APPLICATOR

A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.

MICROPROJECTION ARRAY IMMUNIZATION PATCH AND METHOD

Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

DEVICE TO ASSIST HYPERHYDROSIS THERAPY

VACCINES

The present invention relates to efficient devices for administration of pharmaceutical agents into the skin of the human body. In particular the present invention provides devices for vaccination into the skin. The present invention provides a pharmaceutical agent delivery device having skin-piercing portion comprising a solid reservoir medium containing the pharmaceutical agent, wherein the reservoir medium is coated onto the skin piercing portion. alternatively, the skin piercing portion may consist of the solid pharmaceutical agent reservoir medium. The pharmaceutical delivery devices are proportioned such that agent is delivered into defined layers of the skin, and preferred delivery devices comprise skin-piercing portions that deliver the pharmaceutical agent into the epithelium or the dermis. Preferred reservoir media comprise sugars, and in particular stabilising sugars that forms a glass such as lactose, raffinose, trehalose or sucrose. Furthermore, vaccine delivery devices for ...

MICROARRAY WITH POLYMER-FREE MICROSTRUCTURES, METHODS OF MAKING, AND METHODS OF USE

A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

NEEDLE-LESS PARENTERAL INTRODUCTION DEVICE

A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is palced in the bore of a barrel with the barrel having the shape of a nose cone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into the subcutaneous layer of the patient without the need for penetration of the skin by a needle.

DEVICE AND METHOD FOR ENHANCING TRANSDERMAL AGENT FLUX

An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.

Appareil de vaccination par scarifications.

Appareil pour l'introduction d'une substance biologique dans le corps humain par piqûres multiples simultanées

Dispositif à vacciner

Verpackung mit Geräten zur Intradermal-Applikation

Gerät zur Durchführung von Impfungen, insbesondere solchen gegen Pocken

Impfgerät

IMPFSTEMPEL FUER CUTANE IMPFUNG MITTELS TROCKENIMPFSTOFF.

SCARIFYING DEVICE.

БЛИСТЕРНАЯ ПОЛОСКА

Изобретение относится к блистерной полоске, которая может быть наклеена на кожу, образована по меньшей мере из двух пленок и имеет аппликатор, с помощью которого среда, содержащаяся в блистере, может быть нанесена на кожу или введена в кожу, причем блистерная полоска содержит верхнюю пленку (2), которая имеет по меньшей мере один выступ (2.1), при этом нижняя сторона (2.2) верхней пленки (2), т.е. указанная нижняя сторона, окружающая выступ (2.1), выполнена клейкой, и блистерная полоска имеет нижнюю пленку (3), которая закрывает нижнюю поверхность блистерной полоски и может быть удалена с клейкой нижней стороны (2.2) верхней пленки (2). Выступ (2.1) верхней пленки (2) вмещает аппликатор (1), который делит выступ (2.1) по меньшей мере на два частичных объема, причем аппликатор (1) имеет по меньшей мере одно отверстие (1.2), которое соединяет два частичных объема, при этом один частичный объем расположен между аппликатором (1) и нижней пленкой (3), и при этом по меньшей мере один частичный ...

УСТРОЙСТВО ДЛЯ КОЖНОГО ПРИМЕНЕНИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ

Предлагаемое изобретение относится к устройству (1) для кожного введения пациенту того или иного лекарственного препарата (2), имеющему в своем составе липкий пластырь (3), содержащий упомянутый лекарственный препарат (2), и браслет (4) одноразового использования, содержащий необратимую систему фиксации, позволяющую обеспечить удержание этого лекарственного препарата (2) липкого пластыря (3) в контакте с кожей пациента.

СПОСОБ ВЫПОЛНЕНИЯ РЕВАКЦИНАЦИИ ПРОТИВ ДИФТЕРИИ У ДЕТЕЙ, ПЕРЕБОЛЕВШИХ ГЕПАТИТОМ А

Способ выполнения ревакцинации против дифтерии у детей, переболевших гепатитом А, путем проведения иммунологического скрининга.

СПОСОБ ОПРЕДЕЛЕНИЯ ЧУВСТВИТЕЛЬНОСТИ КОЖИ К ГИСТАМИНУ У ДЕТЕЙ, БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ С СОПУТСТВУЮЩИМ ГИПОТИРЕОЗОМ

Изобретение относится к медицине, а именно к аллергологии и может быть использовано для ранней диагностики и лечения сопутствующего гипотиреоза при бронхиальной астме у детей. Задачей изобретения является разработка способа ранней диагностики и своевременного лечения сопутствующего гипотиреоза при бронхиальной астме у детей путем определения чувствительности кожи к гистамину. Цель достигается путем изучения чувствительности кожи к гистамину у детей, больных бронхиальной астмой и выявлением сопутствующего гипотиреоза. Способ определения чувствительности кожи к гистамину у детей, больных бронхиальной астмой осуществляют путем постановки кожной пробы с серийными разведениями гистамина с подсчетом среднего диаметра папулы. При выявлении стертых, отрицательных проб у больных бронхиальной астмой, что не дает судить о действительном наличии аллергии, диагностируется сопутствующий гипотиреоз. Только после коррекции гипотиреоза заместительной терапией L - тироксином в индивидуально подобранных дозах ...

ПРИСТРІЙ ДЛЯ ШКІРНОЇ ДІАГНОСТИКИ АЛЕРГІЧНИХ ЗАХВОРЮВАНЬ МЕТОДОМ ПРИК-ТЕСТУ

Пристрій для шкірної діагностики алергічних захворювань методом прик-тесту за допомогою компакт-ланцета з попередньо внесеним у його ковпачок розчином алергену, в якому для кращого спрощення тестування одну голку списа ланцета замінено на чотири, що покращує попадання розчину алергену у шкіру і дозволяє спростити технологію тестування.

СПОСОБ ИНТРАКОРПОРАЛЬНОЙ ПРОБИОТИЧЕСКОЙ-СОРБЦИОННОЙ ДЕТОКСИКАЦИИ КОТОВ С АБДОМИНАЛЬНЫМ СЕПСИСОМ

Способ интракорпоральной пробиотической-сорбционной детоксикации котов с абдоминальным сепсисом включает проведение лаважа из инфицированной брюшной полости с помощью сорбента. В качестве сорбента используют средство, которое содержит иммобилизованные на кремнийорганической основе аэросила А-300 производственные штаммы лактобактерий Lactobacillus acidophilus №24 и Lactobacillus rhamnosus №26.

APPARATUS FOR TESTS Of ALLERGY PER PUNCTURE ON the SKIN

APPARATUS FOR MULTIPLE PUNCTURES

Scarifying device

Mechanical provider

Device to be vaccinated

Scarifying instrument for vaccination or skin tests - comprises cylindrical housing with slidable jaws for gripping support of set of sharp points

TRANSCUTANEOUS INJECTION DEVICE

SCARIFYING DEVICE

lancet and lancing device.

METHOD OF CONTROLLING A SURGICAL SYSTEM BASED ON A LOAD ON THE CUTTING TIP OF A HANDPIECE

Transdermal Fluid Delivery Device

A transdermal fluid delivery device includes a housing defining a longitudinal axis and having a proximal end and a distal end. The housing defines a passageway extending longitudinally therethrough. A fluid reservoir is disposed at the proximal end of the housing in communication with the passageway of the housing and is adapted for retaining a fluid therein. A base member is positioned at the distal end of the housing. A microneedle assembly including a plurality of microneedles extending distally therefrom is also provided. The microneedle assembly is selectively moveable with respect to the housing between a retracted position, wherein the microneedles are disposed within the housing, and an extended position, wherein the microneedles are advanced distally to penetrate the base member and extend distally therefrom for puncturing the patient's epidermis and delivering the fluid into the patient's bloodstream.

Glucose Monitoring System

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

Drug delivery devices and methods with collimated gas stream and release-activatable tape

Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.

Method of molding a microneedle

A method of molding a microneedle including providing a mold apparatus having a mold insert having the negative image of at least one microneedle, a compression core, a mold housing configured to allow a reciprocal motion between the mold insert and the compression core. The method includes placing the mold apparatus in a closed position, injecting polymeric material into the closed mold apparatus, compressing the injected polymeric material between the mold insert and the compression core by a reciprocal motion between the compression core and the mold insert, opening the mold, and removing a molded microneedle from the mold. The mold insert has a mold insert height and the molded microneedle has a height that is from about 90% of the mold insert height to about 115% of the mold insert height.

Micro-needle device

An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 μm including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm 2 is applied to the micro-needle device 1 which is in contact with the skin.

Injection needle assembly and drug injection apparatus

An injection needle assembly includes a needle tube having a needle tip to be stuck into a skin, a first member, a second member, an adjustment portion, and a pressing force restricting member. The first member holds the needle tube and the second member holds the first member movably toward the axial direction of the needle tube. A discharge portion of the syringe is fitted into this second member The adjustment portion is provided at the periphery of the needle tube and includes a needle protrusion surface which abuts the skin in a case in which the needle tube is stuck to the living body. The pressing force restricting member is arranged between the first member and the second member, and restricts the pressing force added from the first member to the skin.

Device having array provided with fine protrusions

An array 1 provided with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0<(a/b)≦7.5 holds.

MICRONEEDLE ASSEMBLY FORMULATION FOR SKIN TREATMENT

A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar. 114-. (canceled)15. A microneedle assembly formulation for use in prevention or treatment of skin aging , or treatment of skin scar comprising a platform and a plurality of conical or pyramidal microneedles formed on said platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in said base , whereinsaid objective substance is at least one selected from the group consisting of various growth factors acting on skin cells and substances promoting production of said growth factors in skin cells;the content of the objective substance is from 0.01 μg to 1.0 mg/patch; anda target symptom for prevention or treatment is skin aging, UV-damaged skin, hypertrophic scar, atrophic scar, keloids, acne scar, hair loss, suture wound, burn wound, ulcer, bedsore, diabetic ulcer or a disease requiring angiogenesis.16. The microneedle assembly formulation for skin treatment according to claim 15 , wherein each of said microneedles has a first member with a tip part containing the objective substance and a second member with a bottom part not containing the objective substance.17. The microneedle assembly ...

MICRONEEDLE NASAL DELIVERY DEVICE

The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles. 1. A nasal delivery device comprising a substrate suitable for administration of a composition to a nasal or sinus mucosa , wherein the substrate comprises one or more microneedles.2. (canceled)3. The nasal delivery device of claim 1 , wherein the substrate is selected from the group consisting of: cotton claim 1 , a sponge claim 1 , an inflatable balloon claim 1 , a probe claim 1 , a roller claim 1 , and a polymeric silicone elastomer.4. The nasal delivery device of claim 1 , wherein the at least one or more microneedles are 150 micrometers or less in length.5. The nasal delivery device of claim 1 , wherein the nasal delivery device comprises a reservoir in fluid communication with the microneedle.6. The nasal delivery device of claim 5 , wherein the reservoir comprises an injection port.7. The nasal delivery device of claim 5 , wherein the device comprises a shaft.8. (canceled)9. (canceled)10. The nasal delivery device of claim 6 , wherein the injection port is suitable for attachment of a syringe.11. The nasal delivery device of claim wherein the one or more microneedles are hollow.12. The nasal delivery device of claim 1 , wherein the one or more microneedles are porous.13. The nasal delivery device of claim 1 , wherein the substrate is cotton claim 1 , wherein the cotton is attached to one end of a shaft claim 1 , and the one or more microneedles are ...

Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery

A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface. A plurality of micro-needles on a patch is also disclosed for transdermal drug delivery applications. 1. A micro-milled patch comprising a plurality of micro-needles , said micro-needles comprising a structure comprising a base at a proximal end and a vertex or tip , defining a vertex angle , at a distal end , said needle not extending into the dermis when applied to the skin , wherein said micro-needle is optionally biodegradable.2. The patch of claim 1 , wherein said micro-needles are fabricated using a biodegradable polymer.3. The patch of claim 2 , wherein said micro-needles comprise a bio-active agent.4. The patch of claim 3 , wherein said bioactive agent is a vaccine.5. The patch of claim 1 , wherein said micro-needle comprises a conical configuration.6. The patch of claim 1 , wherein said micro-needle comprises a pyramidal configuration.7. The patch of claim 1 , wherein said micro-needle comprises a cylindrical configuration.8. A single flute straight cutting edge tungsten carbide engraving tool for fabrication of micro-needles having the geometrical parameters of Table 2.9. A method for delivering a bioactive agent to a patient in need thereof comprising applying the patch of to the skin of said patient such that a bioactive agent gains access to the blood stream of said patient wherein said micro-needle does not penetrate the dermis of said ...

Vaccination Method Using Microneedle Arrays

The present invention provides vaccination methods using microneedle arrays which, when applied to the skin of a subject, create a defined total pore volume. Arrays may be chosen of varying total microneedle volumes (small, intermediate or large) for use in immunisation regimes to induce different T-cell and antibody responses in the subject. The present invention also provides kits for use in such vaccination method(s) comprising the appropriate microneedle array(s). 1. A prime-boost vaccination method which comprises:(i) administering a priming vaccine using a microneedle array having a small total microneedle volume; and(ii) administering a boosting vaccine using a microneedle array having a large total microneedle volume.2. The prime-boost vaccination method according to claim 1 , wherein the large total microneedle volume is at least two-fold greater than the small total microneedle volume.3. The prime-boost vaccination method according to claim 1 , wherein the small total microneedle volume is between 0.0005 and 0.014 mm.4. The prime-boost vaccination method according to claim 3 , wherein the large total microneedle volume is at least 0.05 mm.5. The prime-boost vaccination method according to claim 3 , wherein the large total microneedle volume is between 0.07 and 0.25 mm.6. A kit comprising:(i) a microneedle array suitable for administering a priming vaccine having a small total microneedle volume; and(ii) a microneedle array suitable for administering a boosting vaccine having a large total microneedle volume.7. The kit according to claim 6 , wherein the microneedle array suitable for administering a priming vaccine has a total microneedle volume of between 0.0005 and 0.014 mm; and/or the microneedle array suitable for administering a boosting vaccine has a total microneedle volume of at least 0.05 mm.810-. (canceled)11. The method according to claim 1 , wherein the priming vaccine and boosting vaccine are homologous.12. The method according to claim 1 , ...

AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS

Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein. 1. A method of forming a coated microneedle array comprisingproviding a microneedle array comprising a microneedle substrate and a plurality of microneedles;providing a coating substrate;{'sup': '−1', 'providing an aqueous formulation comprising at least one active pharmaceutical ingredient and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.;'}applying the aqueous formulation to the coating substrate;bringing the aqueous formulation and the microneedles of the microneedle array into contact with one another;removing the microneedles from the aqueous formulation; andallowing at least a portion of the aqueous formulation to evaporate.2. The method according to claim 1 , wherein the viscosity is from 500 to 10 claim 1 ,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.3. The method according to claim 1 , wherein the viscosity is from 500 to 8 claim 1 ,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.4. The method according to claim 1 , wherein the aqueous formulation has a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions.5. The method according to claim 1 , wherein the aqueous formulation has a contact angle on a medical grade polymeric material of 65° or greater ...

METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS

Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. 1. A needle array , comprising:a base;a plurality of needle portions each having a tip region having a tapered shape and a plurality of basement regions each having a tapered shape, where the basement regions are arranged on a first surface of the base at a proximal end of each of the basement regions, and each of the basement regions is connected to a proximal end of the tip region at a distal end of each basement region.2. The needle array of claim 1 , wherein a diameter of each of the plurality of needle portions grows faster than linearly with increasing proximity to a proximal end.3. The needle array of claim 1 , wherein a diameter of each of the needle portion basement regions and tip regions decrease from the proximal end of the basement region to a distal end of the tip region.4. The needle array of claim 1 , wherein each of the tip regions is funnel-shaped.5. The needle array of claim 1 , wherein each of the basement regions is funnel-shaped.6. The needle array of claim 1 , wherein each of the tip regions has a conical shape and each of the basement regions has a polygonal shape.7. The needle array of claim 1 , wherein each of the tip regions and each of the basement regions comprises at least one polymer.8. The needle array of claim 1 , wherein each of the tip regions comprises a biodegradable polymer.9. The needle array of claim 7 , wherein the at least one polymer is selected from the group consisting of poly(lactic acid) claim 7 , poly(glycolic acid) claim 7 , poly(lactic acid-co-glycolic acid) claim 7 , poly(caprolactone) claim 7 , polyanhydrides claim 7 , polyamines claim 7 , polyesteramides claim 7 , polyorthoesters claim 7 , polydioxanones claim 7 , polyacetals claim 7 , polyketals claim 7 , polycarbonates claim 7 , ...

INJECTION MOLDED MICRONEEDLE ARRAY AND METHOD FOR FORMING THE MICRONEEDLE ARRAY

Disclosed are injection molded devices including microneedles on a substrate base. The microneedles may include a plurality of nano-sized structures fabricated thereon. The molds used to form the microneedles are assembled from a plurality of mold segments, each defining portions of the microneedles. Upon assembly of the multiple mold segments, microneedle negative cavities are formed. The molds may be used in an injection molding process to form microneedle arrays. Devices may be utilized for interacting with a component of the dermal connective tissue. 1. A method of forming a microneedle array comprising injecting a moldable material into a microneedle negative cavity , wherein the microneedle negative cavity defines a plurality of fabricated nanostructures on a surface , the nanostructures being arranged in a pattern.2. The method according to claim 1 , the method further comprising aligning a first mold segment with a second mold segment claim 1 , the first mold segment including a first microneedle segment and the second mold segment including a second microneedle segment claim 1 , wherein upon alignment of the first and second mold segments the microneedle negative cavity is formed therebetween claim 1 , the first and second microneedle segments each forming part of the microneedle negative cavity.3. The method according to or claim 1 , wherein the microneedle negative cavity defines a microneedle channel mold.43. The method according to any of - claims 1 , the method further comprising aligning a base with the microneedle negative cavity to form a substrate cavity adjacent to the microneedle negative cavity.5. The method according to any of the preceding claims claims 1 , further comprising forming a positive mold master.6. The method according to any of the preceding claims claims 1 , further comprising heating the microneedle negative cavity prior to injecting the moldable material into the microneedle negative cavity.7. The method according to any of the ...

DEVICE FOR DELIVERY OF RHEUMATOID ARTHRITIS MEDICATION

Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures. 1. A device for delivery of a rheumatoid arthritic drug across a dermal barrier , the device comprising:a microneedle and a plurality of nanostructures fabricated on a surface of the microneedle, the nanostructures being arranged in a predetermined pattern; anda rheumatoid arthritis drug in fluid communication with the microneedle.2. The device of claim 1 , wherein the pattern further includes microstructures claim 1 , wherein the nanostructures have a cross-sectional dimension smaller than the microstructures.3. The device of claim 2 , further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional dimension of the microstructures and greater than the cross-sectional dimension of the first nanostructures.4. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers.5. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a center-to-center spacing of from about 50 nanometers to about 1 micrometer.6. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a height of from about 10 nanometers to about 20 micrometers.7. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have an aspect ratio of from about 0.15 to ...

STRUCTURES FOR TRANSDERMAL DRUG DELIVERY

A preparation for the transdermal delivery of a biologically active substance into the body of a patient comprises particles of a formulation comprising the active substance. The particles are irregular in size and shape and may be produced by a low cost manufacturing method such as grinding from a thin film. The particles are angular, i.e. they have sharp edges and corners that allow them to penetrate the outer layer of the skin when subjected to pressure from a roller or an array of blunt-tipped microstructures. Sucrose may be used as an excipient with the active substance to form suitably rigid and angular particles. 1. A preparation suitable for transdermal delivery into the body of a patient , the preparation comprising particles of a formulation that is soluble or biodegradable in the body , the particles being rigid , irregular in shape and angular , whereby they are capable of penetrating the surface of the skin or of a cornea of the patient.2. A preparation according to claim 1 , wherein the formulation comprises a biologically active substance.3. A preparation according to claim 2 , wherein the formulation further comprises at least one excipient in addition to the active substance.4. A preparation according to claim 3 , wherein the excipient is sucrose.5. A preparation according to claim 4 , wherein the ratio of sucrose to the active substance is greater than 60:40.6. A preparation according to claim 5 , wherein the ratio of sucrose to the active substance is less than 20:1.7. A preparation according to claim 1 , wherein at least 50% of the particles have at least one corner characterized in that every pair of faces of the particle that meet at the corner meet at an angle no greater than 90°.8. A preparation according to claim 1 , wherein the mean size of the particles is between 10 nm and 1 mm.9. A preparation according to claim 8 , wherein the mean size of the particles is between 1 μm and 100 μm.10. A transdermal patch comprising:a body layer;means for ...

RAPID DELIVERY AND/OR RECEIVING OF FLUIDS

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. 1. A microneedle structure comprising:a first plurality of microneedles that each include a base portion and a penetrating portion, the base portions of the first plurality of microneedles being arranged at the periphery of a first closed loop lying in a plane, the penetrating portions of the first plurality of microneedles each extending at a respective angle away from the plane of the first closed loop; anda second plurality of microneedles that each include a base portion and a ...

MICRONEEDLE DEVICES AND USES THEREOF

The present disclosure provides devices and uses thereof A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary. 1. A device dimensioned for administration or implantation to an internal tissue of a subject , which device includes a plurality of microneedles adapted to protrude from the device surface so that the microneedles interact with the internal tissue.2. The device of claim 1 , wherein the device is dimensioned for oral claim 1 , sublingual or intraoperative administration.3. The device of claim 1 , wherein the device is dimensioned for intravenous or respiratory administration.4. The device of claim 3 , wherein the internal tissue is a part of a vessel wall.5. The device of claim 1 , wherein the device is dimensioned for vaginal claim 1 , rectal claim 1 , urethral or bladder suppository or pessary.6. The device of any . being dimensioned and constructed to carry a payload claim 1 , which payload is delivered to the internal tissue after interaction with the microneedles.7. The device of claim 1 , wherein a target site of the subject is a viscus.8. (canceled)9. (canceled)10. The device of claim 1 , wherein a target site of the subject is in an internal GI tract.11. (canceled)12. The device of claim 1 , wherein some or all of the microneedles are hollow.13. The device of claim 12 , wherein at least one of the hollow microneedles is cannulated claim 12 , defining a channel that enables storage or introduction of the payload from the other parts of the device.14. The device of claim 1 , wherein ...

COMPOSITE MICRONEEDLE ARRAY INCLUDING NANOSTRUCTURES THEREON

Disclosed are composite microneedles arrays including microneedles and a film overlaying the microneedles. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component. 1. A composite microneedle array comprisinga microneedle assembly that includes a plurality of microneedles; anda film overlaying the microneedles of the microneedle assembly, the film having a first surface and a second surface, the film at least partially conforming to the microneedles, wherein the first surface of the film is adhered to the microneedle assembly, the second surface of the film comprising a plurality of nanostructures formed thereon, the nanostructures being arranged in a predetermined pattern.2. The composite microneedle array according to claim 1 , at least one of the microneedles contains a channel along a length of the microneedle.3. The composite microneedle array according to any of the preceding claims claim 1 , at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers.4. The composite microneedle array according to any of the preceding claims claim 1 , wherein the pattern further comprises microstructures claim 1 , the nanostructures having a cross-sectional dimension smaller than the microstructures.5. The composite microneedle array according to claim 4 , further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional ...

Self-injection device having needle cover with activation preventer

A drug delivery device, including a body ( 104, 116 ) having a reservoir ( 160 ) disposed therein for containing a medicament and an injection needle ( 152 ) for penetrating the skin of a patient, the needle ( 152 ) providing a path for the medicament between the reservoir ( 160 ) and the patient. The device also includes a rotor ( 580 ) rotatably disposed in the body ( 104, 116 ) for activating the device upon rotation of the rotor ( 580 ), a needle cover ( 112 ) for covering the injection needle, and a needle cover clip ( 560 ) disposed on the needle cover ( 112 ) to rotate from a first position preventing rotor rotation to a second position permitting rotor rotation.

METHOD FOR PRODUCING SILICON MICRONEEDLE ARRAYS WITH HOLES AND MICRONEEDLE ARRAY

A method for producing silicon microneedle arrays with drilled holes includes producing a silicon microneedle array. For each microneedle in a plurality of microneedles in the microneedle array, a laser is positioned relative to a microneedle and a drilled hole is drilled into the microneedle array by laser drilling. The drilled holes are drilled in microneedles, in flanks of the microneedles or alongside microneedles. A microneedle array includes a substrate composed of a micromechanical semiconductor material. The microneedle array has microneedles that project from the substrate and has drilled holes. The microneedles are composed of a porous micromechanical semiconductor material. 1. A method for producing microneedle arrays composed of a micromechanical semiconductor material with drilled holes comprising:producing a microneedle array composed of the micromechanical semiconductor material with a flat side and a needle side; and positioning a laser relative to a microneedle in the microneedle array; and', 'drilling a hole into the microneedle array by laser drilling, 'for each microneedle in a plurality of microneedles of the microneedle array2. The method according to claim 1 , wherein the microneedle array comprises a crystalline silicon.3. The method according to claim 1 , wherein the microneedle array comprises porous silicon.4. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the drilled hole is drilled in the microneedle.5. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled in a flank of the microneedle.6. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled alongside the microneedle.7. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled from the needle side of the microneedle array.8. The ...

MICRONEEDLE ARRAY APPLICATOR AND METHOD FOR APPLYING A MICRONEEDLE ARRAY

A microneedle array applicator is configured to apply a microneedle array in cosmetic and medical applications. The microneedle array applicator has a holding apparatus configured to define detachable holding of a microneedle array comprising a planar substrate. The microneedle array applicator also has a drive mechanism for driving the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate. A method for applying a microneedle array includes the microneedle array applicator enabling safe breaking off of the microneedles, optionally laden with an active ingredient, in the skin. 1. A microneedle array applicator for applying a microneedle array in cosmetic and medical applications comprising:a holding apparatus for defined detachable holding of a microneedle array comprising a planar substrate; anda drive mechanism configured to drive the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate.2. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a first actuator configured to provide drive in the first direction and a second actuator configured to provide drive in the second direction.3. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a deflection apparatus configured to deflect a movement of the microneedle array from the first direction into the second direction.4. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a striking apparatus configured to drive the microneedle array.5. The microneedle array applicator according to claim 1 , wherein the drive mechanism is configured to carry out a rotational movement of the microneedle array.6. The microneedle array applicator according to claim 1 , wherein the holding apparatus has an adhesive layer or a snap connection.7. A method for applying a ...

Sharp Tip Carbon Nanotube Microneedle Devices and Their Fabrication

Carbon nanotube needles and needle arrays are described in which the precursor pillars are etched by oxygen plasma treatment to provide tapered and/or sharp-tip needles. Processes, products by process, and devices incorporating the sharp-tip needles are further described. 1. A method of sharp-tip carbon nanotube needle array fabrication , comprising:exposing a plurality of carbon nanotube pillars in an array to oxygen plasma treatment,wherein each pillar is etched into a needle format with a reduced diameter tip relative to a larger diameter base.2. The method of claim 1 , wherein the oxygen plasma treatment is continued until at least some of the needles have a tip diameter of about 10 μm or less.3. The method of claim 2 , wherein a diameter of the pillars before oxygen plasma treatment is at least about 25 μm.4. The method of claim 3 , wherein the pillar diameter before oxygen plasma treatment is about 50 μm.5. The method of claim 4 , wherein the tip diameter produced after oxygen plasma treatment is about 10 μm and the base diameter after oxygen plasma treatment is about 50 μm.6. The method of claim 4 , wherein the tip diameter produced after oxygen plasma treatment is about 5 μm.7. The method of claim 6 , wherein the tip has an outer diameter of 6 μm and an inner diameter of 4 μm.8. The method of claim 2 , wherein the tip diameter produced after oxygen plasma treatment is about 5 μm or less.9. The method of claim 8 , wherein the tip diameter produced after oxygen plasma treatment is about 1 μm or less.10. The method of claim 9 , wherein the tip diameter is about 800 nm.11. The method of claim 10 , wherein the tip includes a sub-micron size lumen.12. The method of claim 11 , wherein the tip includes no lumen.13. The method of claim 2 , wherein the tip includes no lumen.14. The method of claim 2 , wherein the oxygen plasma treatment is a remote treatment.15. The method of claim 14 , wherein the oxygen plasma treatment is dosed at a flow rate of 150 sccm claim 14 , ...

Devices for transdermal drug delivery

A transdermal drug delivery device comprises needles or other means for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. Means are provided for applying the carriers to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

PATCH APPLYING APPARATUS

Apparatus for applying a patch to a subject, the patch having a number of projections thereon, the apparatus including opposable jaws movable between open and engaging positions, wherein in the open position the jaws can receive at least part of the subject, and in the engaging position the jaws can engage the at least part of the subject and a patch support for supporting a patch, and wherein the patch support is for urging the patch against the at least part of the subject. 1) Apparatus that when used applies a patch to a subject , the patch having a number of projections thereon , the apparatus including:a) opposable jaws that when used move between open and engaging positions, wherein in the open position the jaws can receive at least part of the subject, and in the engaging position the jaws can engage the at least part of the subject; and,b) a patch support that when used supports a patch, and wherein the patch support when used urges the patch against the at least part of the subject.2) Apparatus according to claim 1 , wherein the apparatus is for applying the patch to thereby at least partial control at least one application parameter.3) Apparatus according to claim 2 , wherein the at least one application parameter is controlled to thereby at least partially control a depth of penetration of the projections.4) Apparatus according to claim 2 , wherein the at least one application parameter includes at least one of:a) an application force; and,b) an application velocity.5) Apparatus according to claim 1 , wherein the apparatus is adapted to apply a patch at a velocity of at least 1 m/s.6) Apparatus according to claim 1 , wherein the apparatus includes a retaining system for retaining the jaws in the engaging position.7) Apparatus according to claim 1 , wherein the apparatus includes a biasing mechanism for urging the jaws towards the engaging position.8) Apparatus according to claim 7 , wherein the biasing mechanism is used to control application parameters.9 ...

Micro-needle coating method

Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves.

DEVICE FOR APPLYING MICRONEEDLE ARRAY TO SKIN

Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle. 1. An applicator device for applying a microneedle array to skin , comprising:a housing having an application side and an opposed top side;a recess in the housing in which a drug delivery device that includes an array of microneedles can be releasably stored;a button on the top side of the housing, which button can be depressed to drive the drug delivery device out of the recess for insertion into a patient's skin with the microneedles oriented substantially perpendicular to the planar application side; andat least one roller disposed partially in a cavity on the planar application side of the housing, the roller being configured to facilitate (i) complete insertion of the microneedles into the skin and/or (ii) a bond between the drug delivery device and the skin.2. The applicator device of claim 1 , further comprising a drug delivery device that includes an array of microneedles.3. The applicator device of claim 2 , wherein the drug delivery device further comprises a drug storage element claim 2 , which contains a drug formulation claim 2 , and is configured to release the ...

JIG FOR MICRONEEDLE ARRAY PLACEMENT AND MICRONEEDLE ARRAY DEVICE

The invention relates to a jig for microneedle array placement that is provided with a main jig body with through holes through which the microneedles of the microneedle array will pass and a guiding part that guides the microneedle array to be incorporated into the main jig body and leads the microneedles into the through holes, and a microneedle array device using the jig for microneedle array placement. The invention prevents the deformation of the skin surface during puncture and allows penetration of the microneedles to the prescribed depth under the skin. 1. A jig for microneedle array placement comprising:a main jig body having through holes for penetration of microneedles of a microneedle array;a guiding part for guiding said microneedle array incorporated in said main jig body, so that said microneedles are lead to said through holes, andan adhering part provided on a surface of said main jig body.2. The jig for microneedle array placement as claimed in claim 1 , wherein: said main jig body is provided with microneedle array holders for holding said microneedle array incorporated in said main jig body.3. The jig for microneedle array placement as claimed in claim 2 , wherein: said microneedle array holders comprise latches placed to be opposing to each other in said main jig body.4. The jig for microneedle array placement as claimed in claim 3 , wherein: said main jig body is provided with belt connecting holes for connecting fastening belts.5. A microneedle array device comprising: the jig for microneedle array placement as claimed in ; anda microneedle array incorporated and fixed in said jig for microneedle array placement, wherein,said microneedle array comprises microneedle units held by a needle holder, in a state of being sandwiched and fixed between an upper case, and a lower case having a medicinal solution inlet.6. The microneedle array device as claimed in claim 5 , wherein: said upper case has grooves formed for guiding the both ends of said ...

Device and a system for delivery of biological material

The present invention provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological material through a needle or a micro-needle or micro-needles or biodegradable micro-needles. 125-. (canceled)26. A device for delivery of a biodegradable micro-needle across a biological barrier , wherein the micro-needle comprises a therapeutically active ingredient and a biodegradable polymer , wherein the device comprises;a. a micro-needle strip comprising a biodegradable micro-needle, andb. a mechanism to cut a selected portion of biodegradable micro-needle corresponding to the selected dose of the biodegradable micro-needle to be delivered; the mechanism further comprising a main piston and an auxiliary piston for positioning and applying the biodegradable micro-needles to the skin surface; a roll for loading the micro-needle strip of biodegradable micro-needles; a cutter for cutting the biodegradable micro-needles; a flexible wall comprising an opening for discharge of micro-needles and housing holding all the components of the device; wherein, the micro-needle strips comprising at least one biodegradable micro-needle.27. The device as claimed in claim 26 , wherein the geometrical shape of the biodegradable micro-needles is selected from the group consisting of cylindrical claim 26 , conical claim 26 , tapered claim 26 , pyramidal claim 26 , frustoconical and frustopyramidal.28. The device as claimed in claim 26 , wherein the cutting mechanism is a cutter claim 26 , a razor claim 26 , a known claw mechanism made of a sharp edged metal.29. The device as claimed in claim 26 , wherein main piston claim 26 , auxiliary piston claim 26 , and the roll is made of metal claim 26 , plastic claim 26 , polymeric material and combination thereof.30. The device as claimed in claim 26 , wherein biodegradable micro-needles has an outer diameter of from about 10 microns to 100 microns and length ...

INTRADERMAL DELIVERY OF SUBSTANCES

The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage. 1. A method for delivering a substance into skin comprising delivering the substance into an intradermal space within the skin through a small gauge needle inserted into the intradermal space , wherein an outlet of the needle is inserted at a depth within the skin such that leakage of the substance to the surface of the skin is substantially prevented.2. The method of wherein the needle is selected from the group consisting of microneedles claim 1 , catheter needles claim 1 , and injection needles.3. The method of wherein a single needle is inserted.4. The method of wherein multiple needles are inserted.5. The method of wherein the substance is a liquid delivered by pressure directly on the liquid.6. The method of wherein a hormone is delivered.7. The method ...

SOLVENT-CAST MICROPROTRUSION ARRAYS CONTAINING ACTIVE INGREDIENT

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient. 1. A method of making a microstructure array , comprising:dispensing onto a mold having an array of microstructure cavities a formulation comprising a polymer, a therapeutic agent and a solvent, said formulation dispensed in an amount sufficient to at least partially fill the microstructure cavities, said dispensing carried out in the presence of a gas having a solubility in the formulation or the mold that is greater than the solubility of air in the formulation or the mold;drying the formulation; anddemolding from the mold a microstructure array.2. The method of claim 1 , wherein the gas is carbon dioxide.3. The method of claim 1 , wherein the gas is more soluble in the formulation or the mold than oxygen.4. The method of claim 1 , further comprising:dispensing a second formulation on the mold surface to form a second layer; anddrying the second layer.5. The method of claim 4 , further comprising:affixing a backing to the second layer.6. The method of claim 5 , wherein the backing comprises polyethylene terephthalate.7. The method of claim 1 , wherein said dispensing is carried out at atmospheric pressure.8. The method of claim 1 , wherein said dispensing is carried out at a pressure higher than atmospheric pressure.9. The method of claim 1 , wherein the therapeutic agent is selected from a drug claim 1 , a small molecule claim 1 , a peptide or protein claim 1 , or a vaccine.10. The method of claim 1 , further comprising:prior to said dispensing, dissolving or suspending the therapeutic ...

METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS

Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. 1. A method of forming a microprojection array , comprising:(a) dispensing a quantity of a formulation comprising a polymer, a therapeutic agent and a solvent on a mold having a plurality of cavities corresponding to microprojections in a microprojection array,(b) transferring formulation into the plurality of cavities;(c) removing excess formulation from the mold in a manner that retains formulation in each of the plurality of cavities; and(d) drying the formulation to remove the solvent to form the resulting array.2. The method of claim 1 , further comprising:covering the formulation on the mold with a substrate; andafter step (c), disengaging the mold from the covering in a manner that retains formulation in each of the plurality of cavities.3. The method of claim 2 , wherein the substrate is a cover slip.4. The method of claim 1 , wherein removing excess formulation comprises wiping the mold with a wiper.5. The method of claim 1 , wherein said transferring comprises transferring formulation into the plurality of cavities by applying pressure to the substrate when in contact with the formulation dispensed on the mold.6. The method of claim 1 , wherein said transferring comprises pressurizing the mold.7. The method of claim 6 , wherein the mold is pressurized to 50 psi.8. The method of claim 1 , wherein said transferring comprises applying a vacuum to the mold.9. The method of claim 1 , further comprising:dispensing a basement layer on the mold surface; anddrying the basement layer.10. The method of claim 9 , further comprising:affixing the basement layer to a backing.11. The method of claim 1 , further comprising:demolding the microstructure array.12. The method of claim 1 , wherein disengaging the mold achieves a uniform ...

MICRONEEDLE

Provided are a microneedle and a microneedle array which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, 1. A microneedle comprising a frustum and a forward end portion thereon , having a forward end apex angle (A) in the range of 15 to 60° and a forward end diameter (B) in the range of 1 to 20 μm and satisfying the following expression (1) ,{'br': None, 'i': 'H/D', '5\u2003\u2003(1)'}(H: Height of the whole, D: Diameter of bottom surface of the frustum).2. The microneedle of claim 1 , which has a surface roughness represented by the following expression (2) claim 1 ,{'br': None, 'i': 'Rz', '5 nm≦≦10 μm\u2003\u2003(2)'}(Rz: a maximum height of surface roughness).3. The microneedle of claim 1 , which has a surface roughness represented by the following expression (3) claim 1 ,{'br': None, 'i': 'Rz≦', '50 nm≦5 μm\u2003\u2003(3)'}(Rz: a maximum height of surface roughness).4. The microneedle of claim 1 , wherein the whole thereof has a height (H) of 300 to 700 μm and the frustum has a bottom surface having a diameter (D) of 10 to 200 μm.5. The microneedle of claim 1 , which is composed of a thermoplastic resin as a main component.6. The microneedle of claim 5 , wherein the thermoplastic resin is at least one member selected from the group consisting of polycarbonate claim 5 , polypropylene claim 5 , cycloolefin polymer claim 5 , cycloolefin copolymer claim 5 , polyethylene terephthalate claim 5 , acrylic resin claim 5 , polyphenylene sulfide claim 5 , polyether ether ketone claim 5 , polybutylene terephthalate claim 5 , polybutylene naphthalate and polyethylene naphthalate.7. The microneedle of claim 1 , which is formed from a biodegradable resin as a main component.8. The microneedle of claim 7 , wherein the biodegradable resin is at least one member selected from the group consisting of polyglycolic acid claim 7 , polylactic ...

MEDICATION DELIVERY ASSEMBLY

A drug delivery assembly for use in association with an outlet port of an injection device, the assembly including a connector for association with the outlet port of the injection device, a skin interface element including a fluid flow channel in fluid connection with at least one hollow penetrating element deployed for penetrating into a biological barrier and a shield deployed to prevent inadvertent contact with said hollow penetrating element prior to use. The shield being retained in engagement with at least one of the connector and the skin interface element. The skin interface element is mechanically engaged with the connector so as to be displaceable relative to the connector between an inactive position and an active position. The motion of the skin interface element relative to the connector from the inactive position to the active position is effective to disengage retention of the shield. 1. A drug delivery assembly for use in association with an outlet port of an injection device , the assembly comprising:(a) a connector for association with the outlet port of the injection device;(b) a skin interface element including a fluid flow channel in fluid connection with at least one hollow penetrating element deployed for penetrating into a biological barrier; and(c) a shield deployed to prevent inadvertent contact with said hollow penetrating element prior to use, said shield being retained in engagement with at least one of said connector and said skin interface element,wherein said skin interface element is mechanically engaged with said connector so as to be displaceable relative to said connector between an inactive position in which said fluid flow channel is isolated from the outlet port of the injection device and an active position in which said fluid flow channel is in fluid connection with the outlet port of the injection device,and wherein motion of said skin interface element relative to said connector from said inactive position to said active ...

Tissue penetration device

A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoids may drive the lancet using electromagnetic force. Advancement and retraction of a lancet may be controlled by a feedback loop monitoring the position and velocity of the lancet embodiments of the lancet driver can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet and method for using a lancet to maintain the patency of the wound tract once the lancet has cut into the skin. 1. A penetrating member system for injecting a medicament to a body part , comprising:a housing;a penetrating member positioned in the housing, the penetrating member including a widened portion and a tip;a medicament injection source configured to be coupled to the penetrating membera deformable member sealing the housing;wherein, during a medicament injection movement of the penetrating member, the tip pierces the deformable member to produce an opening in the deformable member, the widened portion contacting the deformable member during the injection movement and enlarging the opening; andthe deformable member configured to reseal after a penetrating member tip has penetrated it while injection medicament from the medicament injection source.2. The penetrating member system of claim 1 , wherein after the injection movement claim 1 , the tip retracts into the housing and the opening substantially maintains its shape after the retraction.3. The penetrating member system of claim 1 , wherein during the injection movement claim 1 , the deformable member remains substantially intact.4. The penetrating member system of claim 1 , wherein claim 1 , during the injection movement claim 1 , the portion of the deformable member pierced by the tip becomes flared.5. The penetrating ...

Micro-needle bladder balloon

Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

DEVICE AND USES THEREOF

The present disclosure provides devices and uses thereof. A devices disclosed herein comprises one or more tips, wherein the one or more tips are designed and constructed to initiate penetration by the device; and one or more protrusions in a region adjacent to each tip. In some embodiments, one or more protrusions can be constructed and arranged so that the required penetration force is reduced as compared with that observed for an otherwise identical device lacking the one or more protrusions. Additionally or alternatively, one or more protrusions can be constructed and arranged such that the required pull-out force is increased as compared with that observed for an otherwise identical device lacking the one or more protrusions. 1. A device for penetrating a substrate comprisingone or more tips, wherein the one or more tips are designed and constructed to initiate penetration by the device; andone or more protrusions in a region adjacent to each tip.2. The device of claim 1 , wherein the one or more protrusions are constructed and arranged so that the required penetration force is reduced as compared with that observed for an otherwise identical device lacking the one or more protrusions.3. The device of or claim 1 , wherein the one or more protrusions are constructed and arranged such that the required pull-out force is increased as compared with that observed for an otherwise identical device lacking the one or more protrusions.4. The device of any one of the preceding claims claim 1 , wherein the diameter of the penetration point of each tip is less than 120% of that observed for the otherwise identical device.5. The device of any one of the preceding claims claim 1 , wherein the one or more protrusions are located in a tapered region of each tip.6. The device of any one of the preceding claims claim 1 , wherein the substrate is compliant or non-compliant.7. The device of any one of the preceding claims claim 1 , wherein the substrate is tissue.8. The device of ...

MICRONEEDLE PATCH APPLICATOR

A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch. 1. A microneedle patch applicator , comprising:a housing;a slidably disposed applicator plate, moveable between a retracted position and a deployed position in a reciprocating manner, the applicator plate having an engaging surface and the applicator plate having a cylindrical aperture that passes therethrough, the cylindrical aperture having an internal wall;a spring mounted in such a way that imparts a spring force to the applicator plate when the applicator plate is in the retracted position;a microneedle patch docking mechanism configured in such a way that the docking mechanism captures and holds a microneedle patch in a position proximal the engaging surface of the applicator plate while the applicator plate is in the retracted position; anda latch mechanism that frictionally engages with the internal wall of the cylindrical aperture to hold the applicator plate in place, and when unlatched disengages from the internal wall and permits the applicator plate to move;wherein the applicator plate is placed in the retracted position with the docking mechanism holding the microneedle patch proximal the engaging surface, and when the latch mechanism is unlatched, the applicator plate is propelled by the spring to the ...

MICRONEEDLE PATCH APPLICATOR SUPPORT

A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch. 1. A microneedle patch support , comprising:a housing having a perimeter defining an internal area;an elevated hub disposed within the internal area;wherein the microneedle patch support is sized and dimensioned to support a microneedle patch in such a way that the microneedle patch rests on the elevated hub, and any needles extending from the microneedle patch do not make contact with the microneedle patch support.2. The microneedle patch support of claim 1 , wherein the perimeter defining the internal area is substantially circular in shape.3. The microneedle patch support of claim 1 , wherein the elevated hub is disposed at a location that is substantially at a center point of the internal area.4. The microneedle patch support of claim 1 , wherein the elevated hub comprises a substantially mesa shape with a hollow center at a substantially flat portion of a top of the elevated hub.5. The microneedle patch support of claim 1 , wherein the elevated hub has a hollow center.6. The microneedle patch support of claim 1 , further comprising a removably attached sealing cover extending across the housing and sealing the internal area closed.7. The microneedle patch support of claim 6 , wherein the sealing cover is adhered to ...

Percutaneous application system

The invention relates to an application system for the transepidermal surface administration of medications, said system comprising a container ( 1 ) accommodating a sprayable, active agent-containing composition, a propellant gas source ( 3 ) for pressurized gas consisting of at least 25% v/v of oxygen, and a spraying device ( 2 ), wherein container ( 1 ), propellant gas source ( 3 ), and spraying device ( 2 ) are flow-connected with each other in such a manner that the propellant gas atomizes the sprayable composition and, when the spraying device ( 2 ) is actuated, forces it out of the spraying device ( 2 ), with the composition being forced out of the spraying device ( 2 ) in the form of a conical spray jet at an exit velocity of ≧100 m/s. With the help of the inventive application system active agents can be effectively administered via the skin without causing injury to the skin. As a result of the high exit velocity the penetration rate is especially favorable even when larger molecules are introduced.

SILK FIBROIN-BASED MICRONEEDLES AND METHODS OF MAKING THE SAME

A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery. 1. A microneedle comprising silk fibroin , wherein said microneedle has a base and a penetrating tip , the tip having a dimension ranging from about 50 nm to about 50 μm.2. (canceled)3. The microneedle of claim 1 , further comprising at least one active agent.4. The microneedle of claim 3 , wherein the active agent is selected from the group consisting of proteins claim 3 , peptides claim 3 , antigens claim 3 , immunogens claim 3 , vaccines claim 3 , antibodies or portions thereof claim 3 , antibody-like molecules claim 3 , enzymes claim 3 , nucleic acids claim 3 , siRNA claim 3 , shRNA claim 3 , aptamers claim 3 , viruses claim 3 , bacteria claim 3 , small molecules claim 3 , cells claim 3 , hormones claim 3 , antibiotics claim 3 , therapeutic agents claim 3 , diagnostic agents claim 3 , and any combinations thereof.5. (canceled)6. The microneedle of claim 3 , wherein the active agent retains at least about 30% of its original bioactivity when the microneedle is maintained for at least about 24 hours at a temperature of about room temperature to about 37° C.7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. The microneedle of claim 1 , further comprising one or more biodegradable polymers.12. The microneedle of claim 1 , wherein the microneedle is adapted to degrade at a ...

MULTIPLE DRUG DELIVERY DEVICE

A drug delivery device is provided. The device is a wearable active transdermal drug delivery device which facilitates drug delivery using one or more vaccine cartridges having microneedles as the point of drug delivery. The device may be used to perform multiple vaccine deliveries to the intradermal layer of a patient. 1. A liquid delivery device , the device comprising:one or more generally cylindrical walls;one or more containers, each container comprising a plunger, a plunger spring, a retaining latch, a retraction spring, a liquid storage volume, and one or more needles in fluid communication with the liquid storage volume;wherein each of the one or more containers is slideably received in each of the one or more generally cylindrical walls;wherein the retaining latch of each of the one or more containers restricts movement of the plunger of each of the one or more containers when the device is in a first configuration; andwherein the retaining latch of each of the one or more containers does not restrict movement of the plunger of each of the one or more containers when the device is placed in a second configuration.2. The device of claim 1 , wherein a container further comprises a drug.3. The device of claim 2 , wherein the drug is a vaccine.4. The device of claim 1 , wherein the needles are hollow microneedles.5. The device of claim 1 , wherein the device is moved from the first configuration to the second configuration by application of pressure to a container.6. A cartridge comprising an outer wall and inner container claim 1 , the inner container comprising a piston and one or more microneedles claim 1 , wherein the inner container is slideably received within the outer wall claim 1 , and wherein the cartridge has a pre-activation configuration claim 1 , an activated configuration claim 1 , and a retracted configuration.7. The cartridge of claim 6 , the cartridge further comprising a liquid storage volume in fluid communication with the microneedles claim ...

MICRONEEDLE-CONTAINING DRUG DELIVERY DEVICE TO BE ATTACHED TO EXTERIOR WALL OF VASCULAR VESSEL AND METHOD FOR DRUG DELIVERY THEREWITH

A drug delivery device, which is to be attached to the exterior wall of a vascular vessel, includes: a) a biocompatible device body for surrounding a vascular vessel; b) one or plurality of biocompatible microneedle, which are connected to the interior of the biocompatible device body and capable of penetrating up to the tunica media so as to deliver drug to the vascular smooth muscle cells. The drug delivery device and method enable spatial and temporal control of the drug ejected onto the blood cells and enable insertions of two or more different drugs at different delivery speeds and durations, thereby significantly improving the treatment success rate. 1. A drug delivery device for attachment to the outer wall of a blood vessel , the blood delivery device comprising: a) a body made of a biocompatible material and formed so as to cover the blood vessel; b) one or more needles made of a biocompatible material , which are connected to the inside of the body and inserted into the tunica media of the blood vessel so as to deliver a drug to vascular smooth muscle cells; c) one or more drug reservoirs formed in the body; and d) microchannels formed in the needles and serving to deliver the drug from the drug reservoirs to the tunica media of the blood vessel.2. The drug delivery device of claim 1 , wherein the rate and period of drug delivery by diffusion claim 1 , osmotic pressure claim 1 , and partitioning are controlled by controlling the structure of the microchannels.3. The drug delivery device of claim 2 , wherein the control of the drug delivery rate and period are achieved by controlling the length claim 2 , cross-sectional area or shape of the channels.4. The drug delivery device of any one of to claim 2 , wherein the drug delivery device is configured to deliver two or more different drugs at the same delivery rate or different delivery rates during different periods.5. The drug delivery device of any one of to claim 2 , wherein the biocompatible material is ...

Surgical stapling device with a curved end effector

The present invention includes a surgical stapler having a staple cartridge, an anvil, and a cutting member having a cutting surface, wherein the cutting member is relatively movable with respect to the anvil and the staple cartridge. In at least one embodiment, one of the anvil and the staple cartridge defines a slot which is configured to receive at least a portion of the cutting member and guide the cutting member as it is moved relative to the anvil and the staple cartridge. In these embodiments, the slot can define a path having linear and/or curved portions. In various embodiments, the path can include a curved portion having a first portion that extends away from the shaft axis and a second portion that extends toward the axis. In one embodiment, the path can include a curved portion defined by an arc corresponding to an angle greater than 90 degrees.

Device for the treatment of skin

A skin treatment device includes a roller rotatably mounted about its longitudinal axis and having needles protruding radially outwardly from its peripheral surface, and a device for establishing electrical contact between at least part of the needles and a voltage source having first and second poles, including first and second terminals capable of being electrically connected to the first and second poles, respectively, a first contacting zone electrically connected to first needles, a second contacting zone spaced and electrically insulated from the first contacting zone and electrically connected to second needles, the terminals and the contacting zones being configured such that when the first terminal is connected to the first contacting zone, the second terminal is likewise connected to the second contacting zone. The first and the second needles are each arranged in a row, the rows being separated from each other in a circumferential direction of the roller.

MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS

The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer. 1. A method of manufacturing a transdermal drug delivery device having a microneedle array , comprising:providing a substrate;applying a polymer solution to the substrate to form a base layerdisposing an exposed surface of the base layer with a textured surface having elevated points protruding there from such that the elevated points contact the exposed surface of the base layer;distancing the textured surface from the exposed surface of the base layer such that the elevated points draw out tube-like projections from the exposed surface of the base layer; anddrying the base layer having the tube-like projections to form microneedlescutting the base layer to form the transdermal drug delivery device.2. The method of claim 1 , wherein the microneedles are hollow.3. The method of claim 1 , wherein the microneedles are regularly spaced on the exposed surface of the base layer.4. The method of claim 1 , wherein the step of drying is concurrent with the step of distancing.5. The method of claim 1 , wherein the step of drying can include one of blowing claim 1 , baking claim 1 , exposure to reduced pressure claim 1 , or combinations thereof.6. The method of claim 1 , wherein the substrate is not incorporated into the transdermal drug delivery device.7. The method of claim 1 , wherein the substrate is a backing layer.8. The method of claim 1 , wherein an active agent is included in the polymer solution.9. The method of claim 1 , further comprising loading the microneedles with a composition containing an active agent.10. The method of claim 8 , wherein the composition containing the ...

Method Of Drug Delivery For PTH, PTHrP And Related Peptides

The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu, Leu, Aib, Lys]hPTHrP(1-34)NH. 190-. (canceled)91. A method of treating post-menopausal osteoporosis comprising administering [Glu , Leu , Aib , Lys]hPTHrP(1-34)NHto a woman in need thereof said administering comprising contacting the skin of said woman with a microprojection arraywherein said microprojection array comprises a backing material with a plurality of attached microprojections and a coating on at least a part of one of said microprojections,{'sup': 22,25', '23,28,31', '29', '26,30, 'sub': '2', 'wherein said coating comprises [Glu, Leu, Aib, Lys]hPTHrP(1-34)NH, and'}{'sub': max', '2, 'sup': 22,25', '23,28,31', '29', '26,30, 'wherein said contacting occurs with sufficient force to cause penetration of one or more of said microprojection members into the skin of said woman and wherein said administration results in Cplasma levels of [Glu, Leu, Aib, Lys]hPTHrP(1-34)NHof greater than 200 pg/mL.'}92. The method of wherein said administering results in Cplasma levels of [Glu claim 91 , Leu claim 91 , Aib claim 91 , Lys]hPTHrP(1-34)NHof greater than 300 pg/mL.93. The method of wherein said administering results in Cplasma levels of [Glu claim 91 , Leu claim 91 , Aib claim 91 , Lys]hPTHrP(1-34)NHof greater than 400 pg/mL.94. The method of wherein said administering results in Cplasma levels of [Glu claim 91 , Leu claim 91 , Aib claim 91 , Lys]hPTHrP(1-34)NHof greater than 500 pg/mL.95. The method of wherein the plasma Toccurs at less than one hour post-administration time.96. The method of wherein the plasma Toccurs at less than ½ hour post administration time.97144-. (canceled)145. The method of wherein said microprojection array comprises from about 85 μg to about 230 μg of [Glu claim 91 , Leu claim 91 , Aib claim 91 , Lys]hPTHrP(1-34)NH.146. The method of wherein said microprojection array comprises ...

Method Of Drug Delivery For PTH, PTHrP And Related Peptides

The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu, Leu, Aib, Lys]hPTHrP(1-34)NH. 1144-. (canceled)145. A method of a method of stimulating bone formation in a subject in need thereof comprising administering [Glu , Leu , Aib , Lys]hPTHrP(1-34)NHby contacting the skin of said subject with a microprojection array ,wherein said microprojection array comprises a backing material with a plurality of attached microprojections and a coating on at least a part of one of said microprojections,{'sup': 22,25', '23,28,31', '29', '26,30, 'sub': '2', 'wherein said coating comprises [Glu, Leu, Aib, Lys]hPTHrP(1-34)NH, and'}wherein said contacting occurs with sufficient force to cause penetration of one or more of said microprojections into the skin of said subject.146. The method of wherein said subject has osteopenia.147. The method of wherein said subject is characterized as having bone mineral density at one or more skeletal sites of more than 1 standard deviations below the norm.148. The method of wherein said subject is characterized as having bone mineral density at one or more skeletal sites of more than 2 standard deviations below the norm.149. The method of wherein said subject has osteoarthritis.150. The method of wherein said subject has a bone fracture.151. A method of wherein said bone fracture is selected from vertebral fracture claim 150 , femoral fracture claim 150 , and radial fracture.152. A method of wherein said bone fracture is a traumatic bone fracture.153. A method of wherein said bone fracture is a non-traumatic bone fracture.154. The method of wherein said administering is a once-daily administration.155. The method of wherein said microprojection array is left in place with one or more of said microprojections embedded in the skin after said contacting for a period of from about 3 seconds to about 10 minutes.156. The method of wherein said ...

Controlled Release Structure for Attaching Medical Devices

A medical device for use with a fluid transfer device includes a hub having an open proximal end with a frusto-conically-shaped cavity therein, a distal end and a passageway therethrough. The cavity is part of the passageway. A release element in the passageway of the hub is positioned to block fluid-tight engagement of the frusto-conically-shaped tip with the cavity of the hub. Structure is provided to release at least part of the release element, upon application of a proximally directed force on the hub, to allow the abrupt fluid-tight engagement of the tip and the cavity in the hub.

METHODS AND DEVICES FOR DESMOPRESSIN DRUG DELIVERY

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated. 113-. (canceled)14. A device for modulating urine production in a patient , the device comprising:a) a depot containing a solution of desmopressin in a pharmaceutically acceptable carrier,b) an interface member in fluid communication with the depot for application to the skin of a patient; i) sufficient to establish and maintain a desmopressin concentration in the blood of the patient within the range of about 0.2 to 5 pg/ml and', 'ii) insufficient to induce a desmopressin concentration in the blood of the patient greater than about 5 pg/ml., 'c) means for delivering the desmopressin solution from the depot to the interface member and intradermally or transdermally to the blood of a patient at a flux rate15. The device of claim 14 , wherein the flux rate is between about 5 and 35 ng/hr (5000 to 35 claim 14 ,000 pg/hr).16. The device of claim 14 , wherein the flux rate is between about 10-20 ng/hr.17. The device of claim 14 , wherein the flux rate is between about 5-15 ng/hr.18. The device of claim 14 , wherein the flux rate is about 10 ng/hr.19. The device of claim 14 , wherein the means for delivering the desmopressin solution establishes a first claim 14 , higher flux rate to establish a desmopressin concentration in the blood of a patient within the range and a second claim 14 , lower flux rate to maintain the concentration.20. The device of claim 19 , further comprising a timer for triggering flux rate change.21. The device of claim 14 , wherein the ...

Highly Concentrated Stable Meloxicam Solutions for Needleless Injection

A method for treating pain, inflammation, fever and respiratory complaints in mammals comprising administering by needleless injection to a mammal in need of such treatment an aqueous cyclodextrin-free solution of meloxicam containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base. 1. A method for treating pain , inflammation , fever and respiratory complaints in mammals comprising administering by needleless injection to a mammal in need of such treatment a composition comprising:40 to 80 mg/ml meloxicam;a pharmacologically acceptable organic or inorganic base capable of forming a salt with the meloxicam and selected from the group consisting of meglumine, sodium, potassium and ammonium; anddisodium EDTA;wherein the solution is free of cyclodextrin.2. The method of claim 1 , wherein the administration of the composition is to a large farm animal in need of such treatment.3. The method of claim 1 , wherein the administration of the composition is to a mammal that is at least 50 kg and up to 750 kg.4. The method of claim 3 , wherein the solution is administered in a dosage range of from 0.2 to 1.0 mg of meloxicam/kg of bodyweight of the mammal.5. The method of claim 3 , wherein the mammal is suffering from at least one of acute mastitis claim 3 , diarrhea claim 3 , lameness claim 3 , and oncological indications.6. The method of claim 1 , wherein the solution has a pH of between 8.5 and 9.7. The method of claim 1 , wherein the solution comprises disodium EDTA in an amount such that the weight ratio of meloxicam to disodium EDTA is between 100:1 and 35:1.8. The method of claim 1 , wherein the solution further comprises:a polyethylene glycol;a polyoxyethylene-polypropylene copolymer; andethanol;wherein the solution is free of cyclodextrin, the solution has a pH of between 8.5 and 9, and the solution has a shelf-life after opening of 28 days or more.9. The method according to claim 1 , wherein the pharmacologically acceptable organic or ...

MICRONEEDLE DEVICES AND METHODS

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided. 1. A medical device , comprising:an array of microneedles, anda coating disposed on the microneedles, a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and', 'a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof;', 'wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and', 'wherein the dose-extending component/local anesthetic weight ...

MICRONEEDLE DEVICES AND METHODS

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided. 1. A medical device , comprising:an array of microneedles, anda coating disposed on the microneedles, a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and', 'a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof;', 'wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and', 'wherein the local anesthetic and dose-extending component are in a non-eutectic ...

INTEGRATED MICRONEEDLE ARRAY AND A METHOD FOR MANUFACTURING THEREOF

The invention relates to a method of manufacturing of a microneedle array comprising the steps of selecting a soft production mold comprising a set of microscopic incisions defining geometry of the microneedles, said soft production mold being capable of providing the microneedle array integrated into a base plate; using a filler material for abundantly filling the microscopic incisions of the soft production mold thereby producing the microneedle array with pre-defined geometry integrated into the base plate; wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array 16, a composition comprising a microneedle array, a system for enabling transport of a substance through a barrier and a system for measuring an electric signal using an electrode. 1. A microneedle array comprising a base plate and a set of microneedles integrated with the base plate , wherein the microneedles comprise a porous ceramic material or a porous ceramic composite material having pores , the diameter of the pores ranging from 10 to 200 nanometer.2. The microneedle array according to claim 1 , wherein the microneedles substantially seamlessly transit into the base plate.3. The microneedle array according to claim 1 , wherein said set of microneedles comprises microneedles of different lengths.4. The microneedle array according to claim 3 , wherein said set of microneedles comprises at least a first and a second microneedle being arranged substantially opposite to each other on a periphery of said set claim 3 , wherein said at least the first and the second microneedles have increased length with respect to overall microneedles of said set.5. The microneedle array according to claim 4 , wherein the length of said at least the first and the second microneedles is at least 1-10% larger than the length of the overall microneedles of the set.6. The microneedle array according to claim 1 , wherein the ...

MICRO NEEDLE AND MICRO NEEDLE DEVICE

The micro needle includes a needle and a body. The needle includes an inclined part including an inclined outer wall, a straight part including a straight outer wall, and a recess having a certain depth along the inclined or straight outer wall. The body is coupled to the needle to move or support the needle. The micro needle apparatus includes a micro needle head part, an infrared generator part, and a power supply part. The micro needle head part includes a plurality of micro needles having front ends protruding out of the micro needle head part. When the micro needles are pressed against a skin, the micro needles arrive at a dermis of the skin. The infrared generator part generates an infrared or far infrared ray to the skin through an inside or outside of the micro needle. The power supply part supplies energy required for the infrared generator part to generate the infrared or far infrared ray. 1. A micro needle comprising:a needle comprising an inclined part comprising an inclined outer wall, a straight part comprising a straight outer wall, and a recess having a certain depth along the inclined or straight outer wall; anda body coupled to the needle to move or support the needle;wherein the recess has a screw thread shape extending clockwise or counterclockwise along an outer wall of the needle.2. The micro needle according to claim 1 , wherein the recess has a straight line shape extending along the needle claim 1 , and is recessed a certain depth toward a center of the needle claim 1 , andthe recess is provided in three or more along an outer wall of the needle, or in four with a constant interval along the outer wall at upper, lower, left, and right sides.3. The micro needle according to claim 1 , wherein the recess extends from an end of the inclined part to a portion or end of the straight part claim 1 , and has a plurality of branch shapes.4. The micro needle according to claim 1 , wherein the body has a cylindrical shape and a taper shape that ...

DEVICE AND A SYSTEM FOR DELIVERY OF BIOLOGICAL MATERIAL

The present invention provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological material through a needle or a micro-needle or micro-needles or biodegradable micro-needles. 26. A method for delivering the biodegradable micro-needle from a device wherein the method comprises (a) setting up the portion of the biodegradable micro-needle corresponding to the dose of the biodegradable micro-needle to be delivered , (b) rotating the main piston by half or one rotation in one direction to cut the portion of the biodegradable micro-needle corresponding to a set dose of biodegradable micro-needle (c) rotating the main piston by half or one rotation for the next operation in the same direction to position the auxiliary piston for the next operation (d) applying force on the main piston to position the biodegradable micro-needle on the flexible wall and to deliver the portion of the biodegradable micro-needle corresponding to a set dose of biodegradable micro-needle on to the skin surface , and (e) a release mechanism to re-position the main piston to its original position.27. The method as claimed in claim 26 , wherein the portion of the biodegradable micro-needle corresponding to the selected dose includes the vertical movement of the micro-needle strip comprising of biodegradable micro-needles by a known mechanism.28. The method as claimed in claim 26 , wherein the application of force on the main piston either for positioning the biodegradable micro-needle or delivery on to the skin surface uses energy stored in a spring or any other known mechanism.29. The device for delivery of biodegradable micro-needle and method of delivery claimed in is as described in the description and shown in and . The present invention provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological ...

Drill Device and Method for Forming Microconduits

The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.

INTRADERMAL JET INJECTION ELECTROPORATION DEVICE

An jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array. 1) An electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein , the electroporation device comprising:a housing having an axis extend therethrough;a nozzle at least partially positioned within the housing;a cavity sized to receive at least a portion of the agent cartridge therein, and wherein the nozzle is in fluid communication with the volume of the agent cartridge when the agent cartridge is positioned within the cavity;an array having a plurality of electrodes extending therefrom;a propulsion cartridge configured to operatively engage the agent cartridge when the agent cartridge is positioned within the cavity; anda power supply in electrical communication with the array.2) The electroporation device of claim 1 , wherein the propulsion cartridge is adjustable between an armed configuration and a deployed configuration claim 1 , and wherein the propulsion cartridge is biased toward the deployed configuration.3) The electroporation device of claim 2 , wherein adjusting the propulsion cartridge from the armed configuration to the deployed configuration mechanically expels a portion of the pre-measured dose of agent through the nozzle.4) The electroporation device of claim 2 , further comprising a trigger claim 2 , and wherein the trigger is adjustable between a first ...

DENTAL ANESTHETIC DELIVERY DEVICE

Disclosed herein is a dental anesthetic delivery device. The dental anesthetic delivery device may comprise a handle and a body having a trough with a concave, horseshoe-shaped inner cavity. The inner cavity, which may be positioned over and around the area of a painful tooth, may further provide a soft or otherwise non-irritating interior surface which may comprise materials such as mesh, gauze, padding, or similar. The interior surface may act as a carrier of and delivery platform for various dental anesthetic substances. The dental anesthetic delivery device may incorporate a temperature modulation system that allows for the delivery of heat or cold to the affected area. 1. A dental anesthetic delivery device comprising: a cavity wall;', 'an inner cavity bounded by the cavity wall; and', 'a substrate disposed on an interior surface of the cavity wall, wherein the substrate is configured to deliver medicament to an affected area in an oral cavity upon contact with the affected area; and, 'an applicator comprisinga handle coupled to the applicator.2. The dental anesthetic delivery device of claim 1 , wherein the applicator further comprises an accommodation trough dimensioned to accommodate opposing teeth during use of the dental anesthetic delivery device.3. The dental anesthetic delivery device of claim 1 , wherein the substrate comprises at least one of cotton padding claim 1 , mesh claim 1 , gauze claim 1 , microfiber claim 1 , and synthetic fabric.4. The dental anesthetic delivery device of claim 1 , wherein the substrate comprises at least one of a diffusor claim 1 , a jet injector claim 1 , and a microneedle.5. The dental anesthetic delivery device of claim 1 , wherein the cavity wall comprises at least one of polymeric claim 1 , metallic claim 1 , ceramic claim 1 , composite claim 1 , wooden claim 1 , and naturally occurring materials.6. The dental anesthetic delivery device of claim 5 , wherein the cavity wall comprises polymeric material further ...

TREATMENT DEVICE AND TREATMENT METHOD USING SAME

A high-frequency treatment device according to the present invention can comprise: a handpiece; a plurality of needles formed on one side of the handpiece so as to be able to come out and retract, and receiving a high-frequency current; and a pressing part disposed in the coming out and retracting direction of the plurality of needles, and tensing the skin by applying a predetermined pressure to the skin. The high-frequency treatment device according to the present invention has an effect of enabling pain occurring due to the insertion of a plurality of conventional needles to be alleviated by adjusting the tension of a patient's skin before inserting a plurality of needles such that the needles are smoothly inserted into the skin. 1. An RF energy treatment apparatus , comprising:a handpiece;a plurality of needles formed to advance and retract on one side of the handpiece and supplied with a high frequency current; anda pressurization unit positioned in a direction in which the plurality of needles advances and retracts and providing tension to a skin by applying given pressure to the skin.2. The RF energy treatment apparatus of claim 1 , further comprising a sensing unit sensing a force of the pressurization unit applied to the skin so that the tension of a given amount or more is generated in the skin before the plurality of needles is inserted into the skin.3. The RF energy treatment apparatus of claim 2 , further comprising an indicating unit indicating so that a user is capable of recognizing in case that the tension of the skin by the pressurization of the pressurization unit reaches a given value or more in the sensing unit.4. The RF energy treatment apparatus of claim 2 , wherein if the tension of the skin by the pressurization of the pressurization unit has the given value or more claim 2 , the sensing unit transmits a signal to a controller so that the plurality of needles is inserted into the skin simultaneously or sequentially.5. The RF energy treatment ...

DRUG-HOLDING MICRONEEDLE ARRAY AND MANUFACTURING METHOD THEREOF

The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. 1. A drug-holding microneedle array comprising:a microneedle array having a microneedle substrate and microneedles, the microneedles being positioned in plural on the microneedle substrate and a tip portion of the microneedles projecting via steps; anda drug held on the tip portion and the steps of the microneedles.2. The drug-holding microneedle array according to claim 1 , wherein a size of edges of the steps is more than 10 μm and less than 100 μm.3. The drug-holding microneedle array according to claim 1 , wherein the size of edges of the steps is more than 14 μm and less than 50 μm.4. The drug-holding microneedle array according to claim 1 , wherein a base material of the microneedles is polymers which are injection-moldable or press-moldable.5. The drug-holding microneedle array according to claim 1 , wherein the base material of the microneedles is at least one selected from a group consisting of nylon claim 1 , polycarbonate claim 1 , polylactic acid claim 1 , copolymer of lactic acid and glycolic acid claim 1 , polyglycolic acid claim 1 , polyethylene terephthalate claim 1 , and cyclic olefin polymer.6. The drug-holding microneedle array according to claim 1 , wherein the base material of the microneedles is water-soluble polymers.7. The drug-holding microneedle array according to claim 6 , wherein the base materials of the microneedles is at least one selected from a group consisting of hyaluronic acid claim 6 , sodium chondroitin sulfate claim 6 , carboxymethyl cellulose sodium salt claim 6 , hydroxypropyl cellulose claim 6 , and dextran.8. The drug-holding microneedle array according to claim 1 , wherein the drug is added with a water-soluble polymer or a mixture of the water-soluble polymer and low ...

MOLD FOR MANUFACTURING PERCUTANEOUS ABSORPTION SHEET, AND APPARATUS AND METHOD FOR MANUFACTURING PERCUTANEOUS ABSORPTION SHEET HAVING NEEDLE-LIKE PROTRUSION

Provided are a mold for manufacturing a percutaneous absorption sheet that can be detected from an image, and an apparatus and a method for manufacturing a percutaneous absorption sheet having a needle-like protrusion using the mold. The mold is a mold for manufacturing a percutaneous absorption sheet in which a plurality of needle-like recessed portions are disposed, and the problem is solved by a mold for manufacturing a percutaneous absorption sheet in which the mold has a gray color in which a brightness value in a case where a brightness in an HSL (Hue Saturation Lightness) color space is represented in 256 levels is in a range of 30 or more and 200 or less. 1. A mold for manufacturing a percutaneous absorption sheet in which a plurality of needle-like recessed portions are disposed ,wherein the mold has a gray color in which a brightness value in a case where a brightness in an HSL (Hue Saturation Lightness) color space is represented in 256 levels is in a range of 30 or more and 200 or less.2. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold has a gray color in which the brightness value is in a range of 75 or more.3. The mold for manufacturing a percutaneous absorption sheet according to claim 2 ,wherein the mold has a gray color in which the brightness value is in a range of 150 or less.4. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold has a gray color in which a saturation value in a case where a saturation in an HSL color space is represented in 256 levels is in a range of 0 or more and 25 or less.5. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold includes a transparent resin, a white colorant, and a black colorant.6. The mold for manufacturing a percutaneous absorption sheet according to claim 5 ,wherein a mass ratio between the white colorant and the black colorant is 3:1 to 10:1.7. The mold for ...

MANUFACTURING METHOD OF MICRONEEDLE ARRAY

Provided is a method for manufacturing a microneedle array in which the distal end of a needle-like recessed portion is reliably filled with a drug solution. The problem is solved by a method for manufacturing a microneedle array, including: a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution; a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in a direction parallel to an ejection direction of the drug solution; an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; and a suction step of suctioning a rear surface of the mold. 1. A method for manufacturing a microneedle array , comprising:a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution in a first direction;a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in the first direction;an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; anda suction step of suctioning a rear surface of the mold.2. The method for manufacturing a microneedle array according to claim 1 , wherein the needle-like recessed portion has an opening diameter of 600 μm or more claim 1 , and an angle of 30.0 degrees or more with respect to a flat portion of the mold claim 1 , andan ejection amount of the drug solution ejected to one ...

MICRONEEDLE ARRAYS FOR ACTIVE AGENT DELIVERY

The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided. 1. A method of providing visual verification of microneedle placement in a skin surface , comprising ,providing a microneedle array having a plurality of microneedles attached thereto, said microneedles including an indicatorapplying the microneedle array to a skin surface of a subject such that the microneedles are embedded into the skin surface,verifying successful application of the microneedles through observation of the indicator's presence in the skin.2. The method of claim 1 , wherein the indicator is a dye.3. The method of claim 1 , wherein the indicator forms an image on the skin of the subject.4. The method of claim 1 , wherein the indicator is visible when light is shown onto the microneedles.5. The method of claim 1 , wherein the indicator is a fluorophore.6. The method of claim 5 , wherein the flourophore includes fluorescein.7. A system for delivering siRNA to a subject claim 5 , comprising:an amount of a self-delivering siRNA a base, and', 'a plurality of microneedles attached to the base, said microneedles comprising a bioabsorbable/biodegradable material and being and configured to be detached from the base after being embedded in a skin surface., 'a microneedle array, said microneedle array comprising'}8. The system of claim 7 , wherein the microneedles include a plurality of longitudinal channels.9. The system of claim 8 , wherein the self-delivering siRNA are present in the longitudinal channels.10. The system of claim 7 , wherein the bioabsorbable/biodegradable material is selected from the group consisting of polyvinyl alcohol claim 7 , polyvinylpyrrolidone claim 7 , chitin claim 7 , carboxymethyl ...

FORCE-CONTROLLED APPLICATOR FOR APPLYING A MICRONEEDLE DEVICE TO SKIN

An applicator and method for applying a microneedle device to a skin surface. The applicator can include a first portion comprising a microneedle array, and a second portion coupled to the first portion via a connector. The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. The method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state. 1. An applicator for applying a microneedle array to a skin surface , the applicator comprising:a first portion comprising a microneedle array and defining a first major surface from which the microneedle array protrudes, the first major surface configured to be substantially parallel with the skin surface and configured to be positioned toward the skin surface; anda second portion coupled to the first portion via a connector that directly contacts both the first portion and the second portion, the connector configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when an application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first major surface of the first portion that meets or exceeds a threshold application force, the second portion defining a second major surface, the second major surface configured to be positioned toward the skin surface; whereinthe connector provides audible feedback to a user when the threshold ...

ANTI-CLOGGING AND ANTI-ADHESIVE MICRO-CAPILLARY NEEDLE WITH ENHANCED TIP VISIBILITY

An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers. 1. A capillary tube comprising:a high contrast color marking located at or about the middle of the capillary tube.2. The capillary tube of claim 1 , wherein the capillary tube has an outer surface and an inner surface claim 1 , with the color marking on the outer surface claim 1 , the color marking comprising one or more color marking reagents suitable for visualizing the capillary tube by a microscope claim 1 , and wherein the one or more color marking reagents adhere to the outer surface of the capillary tube.3. The capillary tube of claim 2 , wherein the color marking reagent comprises nanoparticles claim 2 , and wherein the nanoparticles are modified to minimize binding of biological material to the capillary tube from adsorption of proteins and other cellular components.4. The capillary tube of claim 3 , wherein the nanoparticles are selected from the group consisting of: AuNPs claim 3 , AuAgNPs claim 3 , or a combination thereof.5. The capillary tube of claim 2 , wherein the capillary tube has an outer surface and an inner surface ...

THREE-DIMENSIONAL MICROFLUIDICS DEVICES FOR THE DELIVERY OF ACTIVES

A dermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel. 1. A dermal delivery device comprising:(a) film having first and second outwardly facing major surfaces;(b) at least one liquid reservoir contained within the film;(c) at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir;(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel.2. The dermal delivery device of further comprising a sensor.3. The dermal delivery device of wherein the sensor detects an amount of a liquid delivered over time.4. A dermal delivery device comprising:(a) film having first and second outwardly facing major surfaces;(b) a plurality of liquid reservoirs contained within the film;(c) each liquid reservoir being in fluid communication with at least one microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film;(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with at least one microfluidic channel.5. The dermal delivery device of further comprising a sensor.6. The dermal delivery device of wherein the sensor detects an amount of a liquid delivered over time.7. A transdermal delivery device comprising:(a) film having first and second outwardly facing major ...

MICRONEEDLE AND MICRONEEDLE PATCH

An object of the present invention is to provide a microneedle and a method for producing the same that are specialized for individual treatment purposes and can efficiently achieve a treatment effect. The microneedle according to the present invention relates to a microneedle including a drug containing layer, an intermediate layer, and a base layer in order from a tip side, wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer, and a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion. The microneedle according to the present invention can be more easily broken in the intermediate layer than the conventional microneedle, thereby allowing the drug containing layer to be placed to properly target a particular area in epidermis or dermis. Also, drug release from the drug containing layer can be accurately controlled by a shape, a coating, or the like of the drug containing layer, and a range of application of treatment using a microneedle patch can be extended. 1. A microneedle comprising a drug containing layer , an intermediate layer , and a base layer in order from a tip side ,wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer.2. The microneedle according to claim 1 , wherein a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion.3. The microneedle according to claim 1 , wherein the boundary between the drug containing layer and the intermediate layer has a dome shape protruding toward the intermediate layer.4. The microneedle according to claim 1 , wherein the intermediate layer has a concave lens shape.5. The microneedle according to claim 1 , wherein the intermediate layer has an annular shape.6. The microneedle according to claim 1 , wherein a breaking strength of the intermediate ...

Microprojection arrays with microprojections having large surface area profiles

A microprojection array comprising a substrate with a plurality of microprojections protruding from the substrate wherein the microprojections have a tapering hexagonal shape and comprise a tip and a base wherein the base has two substantially parallel sides with a slight draught angle of approximately 1 to 20 degrees up to a transition point at which point the angle increases to from about 20 degrees to about 70 degrees.

MICRONEEDLE UNIT AND INJECTION DEVICE

The purpose of the present invention is to provide a micro-needle unit and an injection device capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration. The micro-needle unit is provided with a plurality of micro-needles disposed on the puncturing side and provided with a flow channel, and drug solution supply needles disposed on the side opposite from the puncturing side in a number less than that of the micro-needles and provided with a flow channel in communication with the aforementioned flow channel, the micro-needle unit thereby being capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration. 1. A microneedle unit comprising:a plurality of microneedles disposed on a puncturing side and provided with flow channels; andmedicinal solution supply needles disposed on a counter-puncturing side in a number less than the number of the microneedles, provided with flow channels communicating to the flow channels of the microneedles.2. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the flow channels of the microneedles are consolidated into the flow channels of the medicinal solution supply needles.3. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the medicinal solution supply needles are provided in a plural number, and the flow channels of the plurality of medicinal solution supply needles confluent into a communication path, to communicate with the flow channels of the microneedles via the communication path.4. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the size of the flow channels becomes smaller gradually from the medicinal solution supply needle toward the microneedle.5. The microneedle unit as claimed claim 1 , wherein claim 1 ,the microneedles and/or the medicinal solution supply needles are composed of two divisional elements bonded with each other.6. The ...

MULTI-SITE ELECTRODE ARRAYS AND METHODS OF MAKING THE SAME

A multi-site electrode array () can include a microneedle array and a set of electrically active sites (). The microneedle array includes a plurality of microneedles () supported on a base substrate (). The set of electrically active sites () can be arranged at and/or near the tip of each microneedle (), and in many cases along a shaft of the microneedles. Further, at least a portion of the active sites () can be independently electrically addressable such that a remaining portion of the active sites () are optionally electrically shunted together. In some cases all of the active sites () are independently electrically addressable 1. A multi-site electrode array comprising:a) a microneedle array including a plurality of microneedles supported on a base substrate; andb) a set of electrically active sites arranged on each microneedle, each active site in the set being independently electrically addressable.2. The array of claim 1 , wherein the array is a two dimensional array such that the plurality of microneedles are distributed in two dimensions across the base substrate.3. The array of claim 1 , wherein the plurality of microneedles are substantially parallel to one another.4. The array of claim 1 , wherein the microneedles and the base substrate are formed of a contiguous and common material.5. The array of claim 1 , wherein a spatial configuration across the plurality of microneedles for the sets of electrically active sites forms a three-dimensional volume of electrically active sites.6. The array of claim 1 , wherein at least a portion of the electrically interactive sites are electrically connected to a base contact via independent lead lines formed of an electrically conductive material deposited along a shaft portion of the microneedles claim 1 , wherein at least a portion of the base contacts are electrically independent of one another.7. The array of claim 1 , further comprising transistor gates and pads oriented on an underside of the base substrate and ...

MICRONEEDLE ARRAY AND METHOD OF USE

An article () comprising at least one microneedle () is provided. The article comprises a first side () and a second side () opposite the first side. The first side comprises a central cavity portion () and a platform portion (), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (); a base segment () having a base () and a first shape; a tip segment () having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane () that delineates the base segment and the tip segment; and a central axis (). Methods of using the article are also provided. 1. An article , comprising:a first side comprising a central cavity portion and a platform portion that projects from the first side and that is not coplanar with the central cavity portion;a second side opposite the first side; andat least three hollow microneedles extending from the platform portion in a first direction;wherein the platform portion substantially surrounds the central cavity portion;wherein the platform portion comprises an inner perimeter proximate the central cavity portion and an outer perimeter distal the central cavity portion; an outer surface;', 'a base segment having a base and a first shape that is defined by a first section of the outer surface;', 'a tip segment having a tip and a second shape that is defined by a second section of the outer surface, wherein the second shape is distinct from the first shape;', 'a transition plane that delineates the base segment and the tip segment; and', 'a central axis;, 'wherein the at least three hollow microneedles each comprise a body that compriseswherein a first angle, defined by the central axis of each of the at least three hollow microneedles and a shortest line extending from the outer ...

Devices for Transdermal Drug Delivery

A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place. 1. A transdermal drug delivery device comprising:a number of needles for piercing the skin of a patient to form a number of pores in the skin;a number of carriers, each carrier being an elongate element having a tip for loading with a drug to be delivered; andmeans operable while the needles remain in the skin for applying each carrier to a pore to deliver the drug to the pore.2. A device according to claim 1 , wherein each of the carriers is located such that it can be introduced into the pore alongside the corresponding needle.3. A device according to claim 1 , further comprising a drug loaded on the tips of the carriers.4. A device according to claim 3 , wherein the drug is adhered to the tips of the carriers.5. A device according to claim 3 , further comprising a channel associated with each carrier claim 3 , along which the carrier can slide claim 3 , wherein the drug is contained within the channel by the tip of the carrier.6. A device according to claim 1 , wherein each of the carriers is movable relative to a corresponding one of the needles.7. A device according to claim 6 , further comprising a channel associated with each carrier claim 6 , along which the carrier can slide.8. A device according to claim 7 , wherein the channel is located in the corresponding needle.9. A device according to claim 7 , comprising a first insert part that defines a first portion of the channel and a second insert part that defines a second portion of the channel claim 7 , the ...

DEVICES, SYSTEMS, AND METHODS FOR INDUCING DERMAL BLOOD VESSEL LEAKAGE

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject. 1. A device comprising:at least one penetration member having a body defined by oppositely disposed proximal and distal ends, the body having a length such that at least a portion of the distal end extends into a dermis of the skin of a subject when the device is contacted with the subject's skin; anda laser source coupled to the at least one penetration member so that, upon activation, the laser source delivers a laser beam into the dermis for a time sufficient to induce leakage or rupture of at least one blood vessel comprising the dermis.2. The device of claim 1 , wherein the penetration member is a needle claim 1 , a microneedle claim 1 , or a microprojection comprising a microneedle array or a microprojection array.3. The device of claim 1 , wherein the penetration member is hollow and the laser source is coupled to an optical fiber that is at least partly disposed within the hollow penetration member.4. The device of claim 1 , wherein the penetration member is made of a solid claim 1 , transparent material such that the laser beam penetrates into the dermis via the penetration member.5. The device of claim 1 , wherein at least part of the device is configured as a handheld claim 1 , point-of-care device.6. The device of claim 1 , wherein at least a portion of the distal end is coated with one or more detection reagents for detecting one or more target analytes in the fluid leaked ...

Microstructure-based Drug Injection Device and Method for Manufacturing the Same

A method for manufacturing a microstructure-based drug injection device according to an embodiment of the present invention includes: a forming mold preparation step for preparing a forming mold formed in a shape corresponding to a microstructure to be manufactured; a biodegradable material-mixed solution application step for applying a biodegradable material-mixed solution to the forming mold; a primary drying step for drying the biodegradable material-mixed solution applied to the forming mold and forming a needle film in which the microstructure is formed; a drug filling step for filling a drug into a filling space formed by the microstructure; and a secondary drying step for drying the needle film, wherein, in the filling space that has undergone the secondary drying step, an inner space portion is formed in a region other than in the region in which the drug is accommodated. 1. A method for manufacturing a microstructure-based drug injection device , comprising:preparing a forming mold having a shape that corresponds to a microstructure to be manufactured;applying a biodegradable material-mixed solution to the forming mold;primary drying to form a needle film where the microstructure is formed by drying the biodegradable material-mixed solution applied to the forming mold;drug filling for filling a drug in a filling space formed by the microstructure; andsecondary drying for drying the needle film,wherein an inner space is formed in an area other than an area where the drug is accommodated in the filling space that has undergone the secondary drying.2. The method for manufacturing the microstructure-based drug injection device of claim 1 , wherein:the drug filled in the filling space is in a fluid state in drug filling; andat least a part of the drug filled in the filling space is permeated into the microstructure in the drug filling.3. The method for manufacturing the microstructure-based drug injection device of claim 2 , whereina droplet diameter of the drug ...

Microneedle Immunotherapeutic Multi-Component System and a Method for Vaccination

A dissoluble microneedle drug delivery system includes a fixation component having an opening window area, and at least two replaceable and/or dissoluble inner matrices fitting into the window area one after another. The fixation component comprises an array of microneedles attached on its base, at least part of the microneedles being configured to fix the delivery system onto skin. The first inner matrix comprises a multitude of microneedles attached on its base, at least part of the microneedles configured to prepare the skin to vaccination by the subsequent second inner matrix. The second inner matrix is a vaccine/immunization matrix configured to replace the first inner matrix and comprising an array of microneedles attached on its base, at least part of the microneedles configured to deliver a vaccination. The system may include a microchannel network within at least one inner matrices for delivery of components regulating dissolution of the microneedles. 1. A dissoluble microneedle drug delivery system , comprising:an outer microneedle matrix, and the outer microneedle matrix optionally mounted on a fixation frame and having an opening window in its center, and having a microneedle array affixed on its base, the microneedle array comprising microneedles of different lengths such that the longest microneedles are located on outer edges of the outer microneedle matrix, and the shorter microneedles are located around the opening window area, the longest microneedles configured to be used for fixation of the matrix onto the skin and additionally for delivery of an adjuvant, and the shorter microneedles being configured to be used for adjuvant preparation of the skin;', 'the first inner matrix fitting into the opening window area and having a microneedle array affixed onto its base, the microneedle array comprising a multitude of dissoluble microneedles containing skin preparation components and being configured to prepare skin underneath the matrix for vaccination ...

3D Printed Microneedles for Microencapsulated Mammalian Cell Extrusion

A 3D printed biocompatible drug delivery device is provided having a fluid delivery channel distinguishing three segments and a receiving chamber with an array of microneedles. The three segments of the delivery channel are stagnation zones before a drug is extruded and whereby an inverted funnel provides an increasing extrusion surface servicing the drug to the array of microneedles. The design of the device with its flow-related components circumvents the challenge of colloidal stability associated with multi-phase formulations leading to nozzle blockage. Qualitative screening cytotoxicity tests pre and post-extrusion through the drug delivery device using mammalian cells rule out cytotoxicity and outline equivalent viability to control treatments. The biocompatibility results suggest that the fluid delivery design, the photoresin selected as well as the fabrication and sterilization may be extended over a range of regenerative medicine and drug delivery applications. 1. A biocompatible drug delivery device , comprising: wherein the first segment is a funnel with a diameter suitable to receive a syringe,', 'wherein the second segment is a cylinder connected to the smallest diameter of the funnel, and wherein the diameter of the cylinder matches the smallest diameter of the funnel,', 'wherein the third segment is an inverted funnel connected to the other side of the cylinder at the smallest diameter of the inverted funnel,', 'wherein the diameter of the smallest diameter of the inverted funnel matches the diameter of the cylinder, and', 'wherein the inverted funnel diverges with an angle ranging from 10 to 45 degrees; and, '(a) a fluid delivery channel distinguishing three segments,'} wherein each microneedle protrudes with an orifice from the bottom surface of the receiving chamber,', 'wherein a section of the top surface of the receiving chamber fluidically connects to the bottom surface of the fluid delivery channel such that the array of microneedles matches up ...

Adhesion Member and Microneedle Patch

The patch or the like of the present invention is useful for pharmaceuticals and the like because the puncturability of microneedle is improved, and a microneedle array can be firmly fixed to the skin, and drugs can be quantitatively administered without waste.

SUSTAINED INTRATONSILLAR DRUG DELIVERY WITH NEEDLE ARRAY

Various embodiments for sustained drug delivery using a needle array are disclosed. A medical instrument and a method associated therewith are described for delivering drugs into tonsillar and other tissue as a way of treating tonsillar hypertrophy or inflammation, as an alternative to tonsillectomy and adenoidectomy (T&A) procedures. In some embodiments, a tonsil-accessible medical instrument is described as including a needle head having needles, or microneedles, disposed therein and capable of introducing a compound, such as a steroid, into tissue. The medical instruments enables for the delivery of various compounds, such as pharmaceuticals, for controlled and sustained release. 1. A medical instrument , comprising:a handle portion;a central member coupled to a distal end of the handle portion; anda needle head coupled to a distal end of the central member, the needle head comprising a needle array disposed in a cavity of the needle head, wherein the needle array comprises a plurality of needles configured with a compound that, when the plurality of needles are introduced into tissue, causes a delivery of the compound into the tissue.2. The medical instrument of claim 1 , wherein the plurality of needles are a plurality of microneedles claim 1 , each of the plurality of microneedles having a needle size of about 250 micrometers to 2 claim 1 ,500 micrometers.3. The medical instrument of claim 2 , wherein the needle head comprises an ovular cylinder.4. The medical instrument of claim 3 , wherein the needle head comprises an elliptically concave inner surface claim 3 , wherein each of the plurality of microneedles are disposed along the elliptically concave inner surface.5. The medical instrument of claim 1 , wherein the central member is C-shaped claim 1 , the central member comprising a first bend forming a first angle between a first portion of the central member and a second portion of the central member claim 1 , and a second bend forming a second angle ...

Microneedle sheet

The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

MICRO NEEDLE

A micro needle includes: a first base; a second base formed integrally with the top surface of the first base; a needle support formed integrally with the top surface of the second base and leading to a tapered groove penetrating the bottom surface of the first base; and a needle body formed integrally with the center of the top surface of the needle support and having a needle hole leading to the tapered groove. The micro needle allows for low-cost mass production because of the simple structure, and involves applying various drugs by injecting drugs after puncturing the skin. 1. A micro needle comprising:a first base;a second base formed integrally with the top surface of the first base;a needle support formed integrally with the top surface of the second base and leading to a tapered groove penetrating the bottom surface of the first base; anda needle body formed integrally with the center of the top surface of the needle support and having a needle hole leading to the tapered groove.2. The micro needle of claim 1 , wherein the first and second bases are disc-shaped claim 1 , and the needle support is cone-shaped.3. The micro needle of claim 1 , wherein the needle support is 1.3 to 1.7 mm long claim 1 , the maximum inner diameter of the tapered groove is 1.5 to 2.5 times the outer diameter of the needle support claim 1 , and the top inner diameter of the tapered groove is 1.5 to 3 times the outer diameter of the needle body.4. The micro needle of claim 1 , wherein the needle body is 0.1 to 1.0 mm long claim 1 , with an outer diameter of 40 to 300 μm claim 1 , and the needle hole has an inner diameter of 30 to 250 μm.5. The micro needle of claim 1 , wherein the needle hole is punched from the bottom of the needle support using a micro drill. This U.S. non-provisional patent application claims priority under 35 U.S.C. § 119 of Korean Patent Application No. 10-2018-0077388, filed on Jul. 4, 2018, the entire contents of which are hereby incorporated by reference.The ...

FLUID DELIVERY APPARATUS AND METHOD OF ASSEMBLY

A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet. The central portion defines an inner step, and the lower wall includes circumferentially-spaced flexible tabs. The fluid delivery apparatus also includes a fluid distribution assembly coupled to the collet assembly. The fluid distribution assembly is positionable relative to the collet between a pre-use configuration and a pre-activated configuration. The fluid distribution assembly has a plenum that includes a sleeve component having an exterior ledge extending thereabout. A lower wall portion of the sleeve component includes protrusions corresponding to the flexible tabs of the collet. In the pre-use configuration the exterior ledge of the sleeve component is engaged with the inner step of the collet assembly, and each flexible tab engages a respective protrusion to provide a snap-fit between the fluid distribution assembly and the collet assembly. 1. A fluid delivery apparatus having a central axis , the fluid delivery apparatus comprising:a collet assembly comprising an upper wall and a lower wall coupled together at a central portion of the collet assembly, the central portion defining an inner step, the lower wall comprising a plurality of flexible tabs spaced circumferentially equidistant about the central axis; anda fluid distribution assembly coupled to the collet assembly, the fluid distribution assembly being positionable relative to the collet assembly between a pre-use configuration and a pre-activated configuration, the fluid distribution assembly comprising a plenum assembly and a cartridge assembly containing a fluid, the plenum assembly comprising a sleeve component having a wall comprising an upper wall portion and a lower wall portion coupled to the upper wall portion and defining an exterior ledge extending about the sleeve component, the lower wall portion comprising a plurality of protrusions spaced circumferentially ...

Microneedle template and microneedle prepared using the same

Provided are a microneedle template including: a substrate on which at least one microneedle shapes are formed; and a diamond layer formed on the surface of the at least one microneedle shapes, a method for preparing the microneedle template, a microneedle prepared using the microneedle template, and a method for preparing the microneedle.

SYSTEM AND METHOD FOR OPTOGENETIC THERAPY

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. 1a. implanting an optical applicator and coupling it to at least one tissue structure such that it can deliver photons to at least one branch of the renal nerve plexus that has been genetically modified to have light sensitive protein;b. implanting an implantable light source and intercoupled implantable power supply and coupling each to at least one tissue structure, the implantable light source being configured to deliver photons as an input to the optical applicator when the implantable light source is drawing power from the implantable power supply;c. deploying an implantable sensor within the body of the patient, the sensor configured to provide an output signal that is correlated with the blood pressure of the patient; andd. implanting an implantable controller and coupling it to at least one tissue structure, the implantable controller configured to cause the implantable light source to direct enough illumination to the light sensitive protein through the implantable light source and implantable light applicator to at least partially inhibit action potential transmission within the at least one branch of the renal nerve plexus based at least in part upon the output signal received from the implantable sensor.. A method for preventing ...

CATIONIC LIPIDS AND TRANSFECTION METHODS

The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells. 2. The compound of claim 1 , wherein n is 2-15.3. The compound of claim 1 , wherein n is 2-12.12. A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier or excipient.13. A lipid aggregate comprising the compound of .14. The lipid aggregate of claim 13 , wherein the lipid aggregate does not comprise one or more additional lipids or polymers.15. The lipid aggregate of claim 13 , further comprising a nucleic acid claim 13 , selected from a DNA or RNA molecule. The present application claims priority to U.S. patent application Ser. No. 16/746,279, filed on Jan. 17, 2020, U.S. Provisional Application No. 62/870,245, filed on Jul. 3, 2019, U.S. Provisional Application No. 62/880,435, filed on Jul. 30, 2019, and U.S. Provisional Application No. 63/023,654, filed on May 12, 2020, the contents of which are herein incorporated by reference in their entireties.The present invention relates, in part, to various novel lipids, including methods, compositions, and products for delivering nucleic acids to cells.The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jul. 3, 2020, is named FAB-012US_ST25.txt and is 1,441,638 bytes in size.Lipid-based materials, such as liposomes, are used as biological carriers for pharmaceutical and other biological applications, e.g., to introduce agents into cultured cell lines. Lipids are commonly used to deliver nucleic acids to cells in vitro under low-serum or serum-free conditions, for instance in transfection. However, serum components inhibit the activity of many lipids, limiting their use in the presence of serum, both in vitro and in vivo. Improved lipid delivery systems, e.g., to achieve higher levels of transfection both in vitro and ...

Method and Device for Manufacturing Dissolving Microneedle

A method and a device for manufacturing dissolving microneedle, wherein the method comprises manufacturing a mold with a plurality of microporous cavities, and manufacturing a polymer solution to be sprayed into the microporous cavity by a high pressure spraying device to enable the sprayed solution to fill in each microporous cavity. After the dryness of the solution, a microneedle is extracted from the mold. The process for manufacturing the microneedle is without vacuum pumping or any load of centrifugal force, and the process is simple and the excellent rate is high. 1. A method for manufacturing dissolving microneedle , comprising manufacturing a microneedle mold , said microneedle mold has a plurality of microporous cavities , wherein a polymer solution is sprayed into the microporous cavity by a high pressure spraying device to enable the polymer solution to fill into each of the microporous cavities; and the solidified microneedle are extracted from the microneedle mold after the dryness of polymer solution.2. The method for manufacturing dissolving microneedle according to claim 1 , wherein said polymer solution sprayed into the microporous cavity by the high pressure spray device comprises the atomized polymer solution sprayed into the microporous cavity by a high pressure atomizing device.3. The method for manufacturing dissolving microneedle according to claim 2 , wherein the particle size of said atomized polymer solution sprayed by the high pressure atomizing device ranges from 0.1 to 100 micrometers.4. The method for manufacturing dissolving microneedle according to claim 1 , wherein said polymer solution sprayed into the microporous cavity by the high pressure spray device comprises the droplets of the polymer solution sprayed to the microporous cavity by the high pressure spotting device.5. The method for manufacturing dissolving microneedle according to claim 4 , wherein the particle size of said droplets of the polymer solution sprayed by the high ...

Device and Method for Producing Microstructures

A device for manufacturing microstructures including a permeable template, wherein the template comprises at least one recess for manufacturing the microstructures. In addition, the device comprises a vacuum-generating device connected to the template such that a vacuum is applied to at least one side of the template. Further, a method for filling a permeable template, wherein the template comprises at least one recess for manufacturing microstructures. The method comprises feeding the at least one substance to be filled in to the template as well as generating a vacuum on at least one side of the template 1. A device for manufacturing microstructures , in particular microneedles , comprising:at least one permeable gas-transmissible template,wherein the at least one template comprises at least one conical recess for manufacturing the microstructures,wherein at least one device is connected to the at least one template for generating a vacuum such that a vacuum is applied to at least one side of the at least one template, in particular at least opposite the at least one recess of the at least one template.2. The device according to claim 1 , further comprising a vacuum chamber connected to the at least one template claim 1 , wherein the vacuum chamber is configured such that the vacuum chamber at least temporarily maintains by itself an externally generated vacuum.3. The device according to claim 2 , wherein the vacuum chamber comprises at least one vacuum chamber opening for connecting to a pump for generating a vacuum in the vacuum chamber.4. The device according to claim 1 , further comprising a coupling device for selectively coupling a vacuum-generating device to the template claim 1 , preferably to the vacuum chamber claim 1 , particularly preferably to the vacuum chamber opening.5. The device according to claim 3 , further comprising at least one self-closing valve for closing the at least one vacuum chamber opening such that an existing pressure ratio inside ...

HOLLOW MICRONEEDLE FOR TRANSDERMAL DELIVERY OF ACTIVE MOLECULES AND/OR FOR THE SAMPLING OF BIOLOGICAL FLUIDS AND MANUFACTURING METHOD OF SUCH HOLLOW MICRONEEDLE

The present invention relates to a micro-needle (7; 8; 9) for the transdermal administration of active molecules and/or for the sampling of biological fluids. The micro-needle (7; 8; 9) is made of polymeric material through photolithography. A cavity is defined in the micro-needle (7; 8; 9). 178978977789. Method for the optical activation of the release of an active ingredient by means of a micro-needle (; ; ) , said micro-needle (; ; ) being made of a polymeric material added with a photosensitive polymer or with a photosensitive compound , a blind cavity () being defined in said micro-needle (; ; ) and containing said active ingredient , comprising the step of:{'b': 7', '8', '9, 'exposing said micro-needle (; ; ) to a coherent radiation having a predetermined wavelength such to energize said photosensitive polymer or said photosensitive compound, said coherent radiation being preferably in the near infrared field.'}278978977789. Method for the thermal activation of the release of an active ingredient by means of a micro-needle (; ; ) , said micro-needle (; ; ) being made of a polymeric material added with metal particles , preferably particles of a noble metal , even more preferably gold particles , a blind cavity () being defined in said micro-needle (; ; ) and containing said active ingredient , comprising the step of:{'b': 7', '8', '9, 'exposing said micro-needle (; ; ) to a coherent radiation having a predetermined wavelength such to heat by radiation said metal particles, said coherent radiation being preferably in the near infrared field.'}4464060353050. Method according to claim 3 , wherein the predetermined distance (f) between the geometric center (C; C) of said external profile (; ) and the geometric center (C; C) of said inner profile (; ) is comprised between 10 micrometers and 200 micrometers claim 3 , preferably between 30 micrometers and 50 micrometers claim 3 , even more preferably about 40 micrometers.5789. Method for obtaining through ...

PILL WITH NEEDLE DELIVERY SYSTEM HAVING OUTWARDLY EXPANDING MECHANICAL ACTUATION

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles. 1. A system comprising: an inner surface defining an interior volume of the capsule; and', 'an outer surface sized to pass through a lumen defined by a lining of a gastrointestinal tract;, 'a capsule comprising a shell havinga carrier sized to fit within the interior volume of the capsule and bearing an array of microneedles; and a foldable biasing member comprising a first end and a second end, the foldable biasing member comprising a flexibly resilient material having a flexibility permitting the first end and the second end to be foldable toward one another for movement from an expanded state toward a collapsed state in which the mechanical actuator fits within the interior volume of the capsule, the flexibly resilient material further having a resiliency that biases the first end and the second end apart from one another for movement from the collapsed state toward the expanded state to move the carrier outwardly upon the mechanical actuator overcoming or escaping from constraint provided by the capsule; and', 'a holder hingedly attached with the first end of the biasing member and comprising a support ...

MICRONEEDLE ELECTROPORATION DEVICE

A microneedle electroporation device is provided, including a housing, a positioning member, an intermediate plate, a first microneedle assembly, a second microneedle assembly, a socket, a first wire, and a second wire. The positioning member is connected to the housing and the intermediate plate. The intermediate plate includes a plurality of first holes and a plurality of second holes. The first microneedle assembly includes a plurality of first microneedles and a first metal connecting portion connected to the first microneedles. The first microneedles pass through the first holes. The second microneedle assembly includes a plurality of second microneedles and a second metal connecting portion connected to the second microneedles. The second microneedles pass through the second holes. The first microneedle assembly and the second microneedle assembly are electrically independent of each other. The first wire connects the socket to the first metal connecting portion. The second wire connects the socket to the second metal connecting portion. 1. A microneedle electroporation device , configured to be connected to an injecting device , wherein the microneedle electroporation device comprises:a housing, having an accommodating space;a positioning member, connected to the housing; a first surface, facing the accommodating space;', 'a second surface, opposite to the first surface;', 'a plurality of first holes, penetrating the intermediate plate from the first surface to the second surface; and', 'a plurality of second holes, penetrating the intermediate plate from the first surface to the second surface;, 'an intermediate plate, connected to the positioning member, and comprising a plurality of first microneedles, passing through the first holes; and', 'a first metal connecting portion, connected to the first microneedles;, 'a first microneedle assembly, disposed between the positioning member and the intermediate plate, and comprising a plurality of second ...

INACTIVATED WHOLE VIRION VACCINE-CONTAINING MICRONEEDLE ARRAY PREPARATION AND METHOD FOR ADMINISTERING THE SAME

Provided is a microneedle. The microneedle array includes a needle portion, which contains an inactivated whole virion influenza vaccine, and a sheet portion. Also provided is an administration method in which the microneedle array is administered and then administered secondly after an interval of equal to or greater than 24 hours and less than 2 months. 1. A microneedle array comprising:a needle portion containing an inactivated whole virion influenza vaccine; anda sheet portion.2. The microneedle array according to claim 1 ,wherein the needle portion contains a water-soluble polymer and dissolves after being inserted into a body.3. The microneedle array according to claim 2 ,wherein the water-soluble polymer is at least one kind of polymer selected from the group consisting of hydroxyethyl starch, dextran, sodium chondroitin sulfate, sodium hyaluronate, carboxymethyl cellulose, polyvinyl pyrrolidone, polyoxyethylene polyoxypropylene glycol, and polyethylene glycol.4. The microneedle array according to claim 1 ,wherein the influenza vaccine is at least one kind of virus selected from the group consisting of an A/H1N1 type, an A/H3N2 type, an A/H5N1 type, and a B type.5. The microneedle array according to claim 2 ,wherein the influenza vaccine is at least one kind of virus selected from the group consisting of an A/H1N1 type, an A/H3N2 type, an A/H5N1 type, and a B type.6. The microneedle array according to claim 1 ,wherein 90% by mass or more of the inactivated whole virion influenza vaccine with respect to a total mass of the vaccine is contained in a region that accounts for not more than 80% of a height of the needle portion from a tip of the needle portion, and/or in a region that extends not longer than 500 μm from a tip of the needle portion.7. The microneedle array according to claim 2 ,wherein 90% by mass or more of the inactivated whole virion influenza vaccine with respect to a total mass of the vaccine is contained in a region that accounts for not more ...

MICRONEEDLE PREPARATION ADMINISTRATION MEMBER FOR PLACEMENT OF OBJECTIVE SUBSTANCE IN DERMIS, AND APPARATUS FOR QUICK ADMINISTRATION OF MICRONEEDLE PREPARATION

The invention is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal. 1. A microneedle preparation administration apparatus comprising:a guide tube having an open front end part and an at least partially closed rear end part;a pedestal having a front end surface perpendicular and flat to length direction of the guide tube, in which at least a part thereof including the front end surface is housed within the guide tube and slides in the length direction; anddriving means for driving the pedestal toward the front end part of the guide tube, andmicroneedle preparations being to be attached to the front end surface of the pedestal, and the microneedle preparations being to be pressed out from the front end part of the guide tube, whereinthe microneedle preparation has a first portion having a tip end part and containing an objective substance, and a second portion having a bottom part and not containing the objective substance, and{'sup': '2', 'the front end surface of the pedestal is struck on skin at a collision pressure of 5 N to 200 N per 1 cm.'}2. The microneedle preparation administration apparatus according to claim 1 , wherein the first portion of the microneedle preparation contains a strength regulator.3. The microneedle preparation administration apparatus according to claim 1 , wherein the guide tube has a cross-sectional surface perpendicular to the length direction of polygonal shape.4. The microneedle preparation administration apparatus according to claim 3 , wherein the polygonal shape is quadrangle.5. The microneedle preparation administration apparatus according to claim 1 , wherein the front end surface of the ...

Microprojection array applicator and method

The present invention relates to applicators for administering microprojection arrays to skin and methods of administering microprojection arrays. One embodiment of the present invention is a device for applying a microprojection array to a skin surface comprising: a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face a flexible section that when collapsed actuates the device; b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward; c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide; d) a microprojection array that is contacted by the cantilevered ring when the ring is activated; e) a skin contact membrane; and f) a skin contact applicator base that attaches to the housing. A further embodiment of the present invention also includes two or more cantilevered rings having a first and a last ring, wherein the cantilevered rings are stacked such that when the device is actuated the first ring is fired such that each successive ring is contacted by the preceding ring. 1. A device for applying a microprojection array to a skin surface comprising:a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face has a flexible section that when collapsed actuates the device;b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward;c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide;d) a microprojection ...

MICRONEEDLE WITH POROUS COATING LAYER, MANUFACTURING METHOD THEREOF AND MICRONEEDLE PATCH WITH THE SAME

The present invention relates to a microneedle coated with a porous coating layer, a manufacturing method thereof and a microneedle patch with the same, which can secure a channel to deliver medicine in a surface of a needle body and improve an efficiency of collecting and delivering the medicine based on merits of a material. 1. A microneedle coated with a porous coating layer , comprising:a needle body hard enough to penetrate an outer skin layer; anda coating layer coated to surround the needle body,wherein the needle body is made of metal,wherein the coating layer comprises a plurality of communicating holes recessed or penetrated to be filled with medicine,wherein the plurality of communicating holes communicate with one another to form a moving path of the medicine,wherein the coating layer is made of a soft material comprising at least one of biocompatible polymer and biocompatible hydrogel; and water-soluble porogen different in state from the soft material,wherein the communicating holes are recessed or penetrated as the porogent is removed from the coating layer,wherein the porogen comprises at least one of phosphate buffer saline (PBS), water-soluble hydrogel, and salt,wherein the needle body is shaped like a horn or a column, a tip of which is formed by its material characteristic.2. The microneedle coated with the porous coating layer according to claim 1 , whereinthe biocompatible polymer comprises at least one of poly lactic-co-glycolic acid (PLGA) and poly lactic acid (PLA), andthe biocompatible hydrogel comprises at least one of poly ethylene glycol (PEG), poly ethylene glycol diacrylate (PEGDA), and poly ethylene glycol methyl ether acrylate (PEGMEA).3. A method of manufacturing a microneedle of which a needle body is coated with a coating layer claim 1 ,the method comprising:an emulsion producing operation of dissolving a soft material as a raw material of the coating layer in a solvent and mixing porogen with the dissolved soft material to ...

A microneedle patch

The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

MICRONEEDLE SHEET

A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin. 19-. (canceled)10: A method for administrating an active component , comprising the steps of:preparing a microneedle sheet comprising a sheet including a principal surface extending along each of a longitudinal direction and a width direction, and a plurality of microneedles formed in the sheet, each of the plurality of microneedles having a tip and each said tip facing toward a first end of the sheet in the longitudinal direction;bending a first portion of the microneedle sheet not in contact with skin at a first acute angle along the width direction to raise, from the principal surface, thereby forming a first bent portion, at least one first microneedle located in the first bent portion;piercing the skin with the raised at least one first microneedle;with the raised at least one first microneedle piercing the skin, bending a second portion of the microneedle sheet not in contact with the skin at a second acute angle along the width direction to raise, from the principal surface, thereby forming a second bent portion, at least one second microneedle located in the second bent portion; andwith the raised at least one first microneedle piercing the skin, further piercing the skin with the raised at least one second microneedle.11: The method according to claim 10 , wherein the at least one first microneedle comprises a plurality of first microneedles claim 10 , andthe at least one second microneedle comprises a plurality of second microneedles.12: The method according to claim 10 , wherein the raising of the the at least one first microneedle comprises sequentially raising lines of the at least one first microneedle claim 10 , line by line claim 10 , and wherein the raising of the at least one ...

SYSTEM AND METHOD FOR OPTOGENETIC THERAPY

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. 1a. selecting a targeted tissue structure to be stimulated using illumination at a first subcutaneous location;b. providing an implantable light conductor configured to be permanently coupled between the first subcutaneous location and a second location selected such that extracorporeal photons directed toward the second location will be transmitted, at least in part, through the implantable light conductor to the targeted tissue structure.. A method for stimulating a tissue structure comprising light sensitive protein, comprising: This is a continuation application of U.S. patent application Ser. No. 15/803,473, filed on Nov. 3, 2017, which is a continuation of U.S. patent application Ser. No. 15/473,458, filed on Mar. 29, 2017, which is a continuation of U.S. patent application Ser. No. 14/449,081, filed on Jul. 31, 2014, which is a continuation application of International Application No. PCT/US2013/000262, filed on Nov. 21, 2013, which claims priority to U.S. Provisional Application Ser. No. 61/729,283, filed on Nov. 21, 2012. The foregoing applications are hereby incorporated by reference into the present application in their entirety. Priority to the aforementioned applications is hereby expressly claimed in accordance with 35 U.S.C. § § 119, ...

SKIN TREATMENT SYSTEMS AND METHODS USING NEEDLES

A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit, a waste conduit and/or an energy delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip and a plurality of needles generally positioned within the peripheral lip. The tip also comprises at least one opening in fluid communication with a fluid delivery conduit, at least one opening in fluid communication with a waste conduit and/or an energy contact point in electrical communication with an energy contact point and energy conduit in the main body portion. The plurality of needles may be movable with respect to the peripheral lip through the use of a pneumatic or other force. 1 'a working end that includes a plurality of needles configured to engage and penetrate the skin and positioned on a plane parallel to a peripheral lip on the working end of the skin treatment device;', 'placing the working end of a skin treatment device against a portion of the skin of the patient wherein the skin treatment device comprisescausing the plurality of needles to penetrate the skin; andremoving the working end of the skin treatment device from the portion of skin.. A method for treating the skin of a patient, the method comprising: This application is a continuation application of U.S. patent application Ser. No. 14/211,089, filed Mar. 14, 2014, which claims the priority benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 61/788,420, filed Mar. 15, 2013, the entireties of both of which are hereby incorporated by reference herein.This application relates generally to skin treatment, and more specifically, to apparatuses, systems and methods for treating a person's skin using one or more needles and/or other penetrating members.Abrasion of the outer layer or epidermis of the skin is desirable to smooth or ...

SUBSTANCE DELIVERY DEVICE AND SUBSTANCE DELIVERY METHOD USING THE SAME

A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques. 1. A substance delivery device comprises:a substrate attaching to a tissue;a plurality of dissolvable supporting structures disposed on the substrate; anda plurality of carriers disposed on the dissolvable supporting structures and encapsulating the substances.2. The substance delivery device according to claim 1 , wherein the dissolvable supporting structures can be dissolved in the tissue.3. The substance delivery device according to claim 1 , wherein the dissolvable supporting structures include polyvinylpyrrolidone claim 1 , polyvinyl alcohol claim 1 , γ-poly-glutamic acid claim 1 , hyaluronic acid claim 1 , starch claim 1 , gelatin claim 1 , or their combinations.4. The substance delivery device according to claim 1 , wherein substances are encapsulated in the dissolvable supporting structures claim 1 , and the substances are the same as the substances encapsulated in the carriers.5. The substance delivery device according to claim 1 , wherein substances are encapsulated in the dissolvable supporting structures claim 1 , and the substances are different from the substances encapsulated in the carriers.6. The substance delivery device according to claim 1 , wherein the carriers include a material capable of melting after exposure to a radiation.7. The substance delivery device according to claim 1 , wherein the components of the carriers include chitosan ...

MICRONEEDLE ARRAY WITH COMPOSITE FORMULATION, AND METHOD FOR MANUFACTURING SAME

The present invention relates to a microneedle array and a method for manufacturing the same, the microneedle array comprising: a support; and a plurality of microneedles loaded with a solid-phase formulation which protrude from the upper portion of the support, wherein a liquid-phase formulation is applied or added dropwise onto an area of the upper portion of the support in which the microneedles are not formed, or in a case where one or more holes are formed in the support, the liquid-phase formulation is released, through the holes, onto the area of the upper portion of the support in which the microneedles are not formed. 1. A microneedle array , comprising:a support; anda plurality microneedles loaded with a solid-phase formulation material which protrude from the upper portion of the support,wherein a liquid-phase formulation material is applied or added dropwise onto an area of the upper portion of the support in which the microneedle is not formed, or in a case where one or more holes are formed in the support, the liquid-phase formulation material is released, through the holes, onto the area of the upper portion of the support in which the microneedle is not formed.2. The microneedle array according to claim 1 ,wherein the microneedle is loaded with two or more solid-phase forming materials to form a multi-layer structure.3. The microneedle array according to claim 1 ,wherein a type of the liquid-phase formulation material is the same as or different from that of the solid-phase formulation material.4. The microneedle array according to claim 3 ,wherein in a case where the type of the liquid-phase formulation material is different from that of the solid-phase formulation material, the liquid-phase formulation material contains a fat-soluble material including one or more selected from the group consisting of horse oil, vitamin A and a derivative thereof, vitamin D and a derivative thereof, vitamin E and a derivative thereof, vitamin K and a derivative ...