10-03-2022 дата публикации
Номер: US20220073598A1
Принадлежит:
The invention relates to Bone Morphogenetic Protein 6 (BMP6) antagonists, such as antibodies and fragments, as well as methods, uses and combinations. 1: An antibody or antigen binding fragment thereof comprising a binding site which specifically binds to Bone Morphogenetic Protein 6 (BMP6) , wherein: (i) the binding site comprises a VH , wherein the VH domain comprises a CDRH1 comprising SEQ ID NO: 111 , a CDRH2 comprising SEQ ID NO: 112 , and a CDRH3 comprising SEQ ID NO: 113; and (ii) the binding site comprises a VL domain , wherein the VL domain comprises a CDRL1 comprising SEQ ID NO: 120 , a CDRL2 comprising SEQ ID NO: 121 and a CDRL3 comprising SEQ ID NO: 122.2. (canceled)3: The antibody or antigen binding fragment thereof according to claim 1 , wherein the VH domain is encoded by a nucleotide sequence that is derived from the recombination of a human VH gene segment claim 1 , DH gene segment and JH gene segment claim 1 , wherein the(a) VH gene segment is selected from IGHV3-11 and IGHV1-3;(b) the DH gene segment is a human gene segment selected from IGHD3-10, IGHD6-19, IGHD7-27, IGHD4-23, IGHD5-18, IGHD3-22 and IGHD3-16; and/or(c) the JH gene segment is a human gene segment selected from IGHJ3, IGHJ4 and IGHJ5.4. (canceled)5: The antibody or antigen binding fragment thereof according to claim 1 , wherein the binding site comprises a VH domain comprising SEQ ID NO: 114 paired with a VL domain comprising SEQ ID NO: 123.6. (canceled)7: The antibody or antigen binding fragment thereof according to claim 1 , wherein the binding site comprises a VH domain that comprises SEQ ID NO: 114 claim 1 , or an amino acid that is at least 85% identical thereto.8: The antibody or antigen binding fragment thereof according to claim 1 , comprising first and second copies of said VH domain claim 1 , and/or first and second copies of said VL domain.910-. (canceled)11: The antibody or antigen binding fragment thereof of claim 1 , wherein the VL domain is encoded by a nucleotide ...
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