24-01-2019 дата публикации
Номер: US20190024022A1
Принадлежит:
NOVOZYMES A/S
The invention concern compositions and methods that are effective at removing the soils on medical and dental instruments. The disclosed compositions provide improved cleaning compared to known enzymatic compositions for cleaning medical and dental instruments. 1. A method for cleaning a medical or dental instrument comprising: i) from 0.001% w/w to 1% w/w of a protease, and', 'ii) from 0.001% w/w to 1% w/w of a peptide aldehyde protease stabilizer;, '(a) soaking the medical or dental instrument in an aquous composition comprising'}(b) optionally washing the instrument with a liquid detergent composition; and(c) rinsing the instrument; i) H is hydrogen;', 'ii) B0 is a single amino acid residue with L- or D-configuration of the formula —NH—CH(R)—C(═O)—;', 'iii) B1 and B2 are independently single amino acid residues;', 'iv) B3 is a single amino acid residue, or is absent;', 'v) R is independently selected from the group consisting of C1-6 alkyl, C6-10 aryl or C7-10 arylalkyl optionally substituted with one or more, identical or different, substituents R′;', 'vi) R′ is independently selected from the group consisting of halogen, —OH, —OR″, —SH, —SR″, —NH2, —NHR″, —NR″2, —CO2H, —CONH2, —CONHR″, —CONR″2, —NHC(═N)NH2;', 'vii) R″ is a C1-6 alkyl group;', 'viii) P is an N-terminal protection group; and', 'ix) M is H or an alkali metal, preferably Na or K., 'wherein the peptide aldehyde protease stabilizer has the formula P—B3-B2-B1-B0-H or a hydrosulfite adduct thereof having the formula P—B3-B2-B1-N(H)—CHR—CHOH—SO3M, wherein'}2. The method of claim 1 , wherein the protease is a subtilisin.3. The method of or claim 1 , wherein the medical or dental instrument is soaked in the aquous composition in (a) for a time sufficient to reduce soil on the instrument claim 1 , preferably for at least 1 minute.4. The method of claim 1 , wherein the detergent composition in (b) consists of a surfactant and other ingredients used in detergent and cleaning compositions.5. The method of ...
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