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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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05-01-2012 дата публикации

Sensitivity enhancement in grating coupled surface plasmon resonance by azimuthal control

Номер: US20120002203A1

Автор: Chee Cheong Wong, Filippo Romanato, Gianluca Ruffato, Husen Kartasamita Kang, Lee Kwang Hong

Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY, UNIVERSITA DEGLI STUDI DI PADOVA

A method and a system for the enhancement of the sensitivity in surface plasmon resonance (SPR) sensors based metallic grating by exploiting the conical configuration is presented. We consider the propagation of surface plasmon polaritons (SPPs) excited by light from the visible to infrared spectrum range, incident on a plasmonic grating at different directions by varying both the zenith and azimuthal angles. For specific azimuthal angles, SPPs propagate in the grating plane perpendicular to the incident light momentum. This is the condition that allows increasing the number of different excited SPPs modes largely. We exploit this effect to increase the sensor sensitivity with the change of refractive index of thin film on the plasmonic grating surface. Polarization effects also contribute to a further modes enhancement and increase the sensitivity. A scheme for a lab-on-chip implementation of a system that allows a parallel detection in microfluidic channels has been shown.

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Номер записи: 1

12-01-2012 дата публикации

Multilayer Hydrodynamic Sheath Flow Structure

Номер: US20120009025A1

Автор: Bernard Bunner, John R. Gilbert, Manish Deshpande

Принадлежит: Cytonome ST LLC

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

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Номер записи: 2

26-01-2012 дата публикации

Optics collection and detection system and method

Номер: US20120021525A1

Автор: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner

Принадлежит: Pacific Biosciences of California Inc

Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

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Номер записи: 3

02-02-2012 дата публикации

On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference

Номер: US20120026509A1

Автор: Axel Scherer, Changhuei Yang, Demetri Psaltis, Xin Heng, Xiquan Cui

Принадлежит: California Institute of Technology CalTech

A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

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Номер записи: 4

02-02-2012 дата публикации

Mixing device and mixing method for mixing small amounts of liquid

Номер: US20120028293A1

Автор: Achim Wixforth, Christoph Gauer

Принадлежит: Beckman Coulter Inc

The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied, in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.

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Номер записи: 5

16-02-2012 дата публикации

Microreactors With Connectors Sealed Thereon; Their Manufacturing

Номер: US20120040448A1

Автор: Jean-Marc Martin Gerard Jouanno, Olivier Lobet, Ronan Tanguy, Stéphane Poissy, Sylvain Maxime F. Gremetz

Принадлежит: Corning Inc

The present invention deals with microfluidic devices ( 200 ) including a microreactor ( 20 ) and at least one connector ( 101 ) sealed thereon. It also deals with a method for manufacturing such microfluidic devices and to blocks of material suitable as connector.

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Номер записи: 6

16-02-2012 дата публикации

System and method for automated generation and handling of liquid mixtures

Номер: US20120040472A1

Автор: Krzysztof Churski, Marcin Izydorzak, Piotr Garstecki, Piotr Korczyk, Sławomir Jakieła, Sylwia Makulska, Tomasz Kamiński

Принадлежит: INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK, PZ CORMAY SA

The invention relates to a system ( 1 ) for supplying a microfluidic subsystem with liquids, comprising a first valve ( 14, 29, 46 ) and a first fluidic duct ( 10, 25, 28 ), for connecting said first valve ( 14, 29, 46 ) with said microfluidic subsystem and supplying a first liquid, and a second fluidic duct ( 11 ), for connecting with said microfluidic subsystem and supplying a second liquid characterized in that said first valve ( 14, 29, 46 ) is suitable for closing with time resolution not worse than 100 msec, and parameters of said first fluidic duct ( 10, 15, 28 ) are chosen such that the value of X 1 [Pa −1 ], defined as: X 1 [Pa −1 ]=(0.5×10 −9+1/ E 1 )(α R1 L 1 2 /A 1 ) is lower than 10 4 Pa −1 , where E 1 is the Young modulus of the material, of which said first fluidic duct ( 10, 25, 28 ) is made, L 1 is the length of the said first fluidic duct ( 10, 25, 28 ), A 1 is the surface area of the lumen of the said first fluidic duct ( 10, 25, 28 ) and α R1 is a constant characterizing the geometry of the said first fluidic duct ( 10, 25, 28 ) in an equation for the hydraulic resistance R 1 of the said first fluidic duct: R 1 =α R1 ( L 1 μ/A 1 2 ) with μ denoting the dynamic viscosity coefficient of the fluid filling the said first fluidic duct ( 10, 25, 28 ) in the measurement of R 1 . The invention relates also to a method for producing microdroplets on demand in such a system.

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Номер записи: 7

08-03-2012 дата публикации

Process for treating and/or forming a non-newtonian fluid using microchannel process technology

Номер: US20120058063A1

Автор: Anna Lee Tonkovich, David Kilanowski, Eric Daymo, Ravi Arora

Принадлежит: Individual

The disclosed invention relates to a process, comprising: conducting unit operations in at least two process zones in a process microchannel to treat and/or form a non-Newtonian fluid, a different unit operation being conducted in each process zone; and applying an effective amount of shear stress to the non-Newtonian fluid to reduce the viscosity of the non-Newtonian fluid in each process zone, the average shear rate in one process zone differing from the average shear rate in another process zone by a factor of at least about 1.2.

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Номер записи: 8

08-03-2012 дата публикации

Blood Chamber for an Optical Blood Monitoring System

Номер: US20120059234A1

Автор: Louis L. Barrett, Perry N. Law

Принадлежит: Hema Metrics LLC

An extracorporeal blood chamber for an optical blood monitoring system includes an opaque chamber body in order to prevent inaccuracies when measuring oxygen saturation levels due to light ducting, which can occur at low oxygen saturation levels and low hematocrit levels. In one embodiment, the blood chamber need not include a moat as is present in conventional blood chambers.

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Номер записи: 9

29-03-2012 дата публикации

Fiber probe based microfludic raman spectroscopy

Номер: US20120075627A1

Автор: Gajendra Pratap Singh, Khay Tan, Kishan Dholakia, Praveen Cheriyan Ashok

Принадлежит: University of St Andrews

A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.

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Номер записи: 10

29-03-2012 дата публикации

Modular Component Synthesis Unit

Номер: US20120076692A1

Автор: Reza Miraghaie

Принадлежит: Siemens Medical Solutions USA Inc

A kit, for synthesizing a compound or element, which includes a modular reagent source, a modular trap and release apparatus, and a modular reaction unit. The modular reagent source includes a reagent. The modular trap and release apparatus is configured to separate components of the reagent. The modular reaction unit which is in fluid communication with the modular reagent source and the modular trap and release apparatus. In addition, the modular reaction unit includes a reaction vessel configured to facilitate a chemical reaction.

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Номер записи: 11

29-03-2012 дата публикации

Thermal Microvalves

Номер: US20120077231A1

Автор: Brian N. Johnson, Mark A. Burns, Michael Chen

Принадлежит: University of Michigan

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

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Номер записи: 12

19-04-2012 дата публикации

Systems and methods for collecting tear film and measuring tear film osmolarity

Номер: US20120090388A1

Автор: Benjamin Sullivan, Eric Donsky

Принадлежит: Tearlab Res Inc

A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

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Номер записи: 13

10-05-2012 дата публикации

Micro-fluidic system and the use thereof

Номер: US20120114534A1

Автор: Rik van der Heijden

Принадлежит: CHEMTRIX BV

The invention relates to a micro-fluidic system comprising: a. a planar micro-fluidic device comprising a plurality of inlets and at least one outlet; b. a holder comprising a first part being provided with a plurality of channels having first ends and second ends, the holder comprising a fixing means for clamping the micro-fluidic device; c. sealing means being arranged to connect the plurality of inlets and the at least one out-let of the micro-fluidic device to the second ends of the plurality of channels, the sealing means being arranged such that a surface contact between the micro-fluidic device and the sealing means and a surface contact between the sealing means and the first part of the holder is established characterized in that the first part of the holder is optionally provided with a first recess for accommodating the planar micro-fluidic device, the second ends of the plurality of channels being located within the optional first recess and at least one second recess is provided for accommodating the sealing means, the second ends of the plurality of channels being located in the at least one second recess. The present invention also relates to the use of such a micro-fluidic systems at high pressures and high temperatures.

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Номер записи: 14

31-05-2012 дата публикации

Systems And Methods For Multi-Wavelength SPR Biosensing With Reduced Chromatic Aberration

Номер: US20120133943A1

Автор: Anping Liu, Guangshan Li, Jinlin Peng, Norman Henry Fontaine

Принадлежит: Corning Inc

Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.

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Номер записи: 15

31-05-2012 дата публикации

Multi-Shell Microspheres With Integrated Chromatographic And Detection Layers For Use In Array Sensors

Номер: US20120135396A1

Автор: Adrian Goodey, Dean P. Neikirk, Eric Anslyn, Jason Shear, John T. McDevitt

Принадлежит: University of Texas System

The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology, complexing ligands have been selectively immobilized to create “separation” layers harboring an affinity for various analytes. Information concerning the identities and concentrations of analytes may be drawn from the temporal properties of the beads' optical responses, Varying the nature of the ligand in the separation shell yields a collection of cross-reactive sensing elements well suited for use in array-based micro-total-analysis systems.

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Номер записи: 16

31-05-2012 дата публикации

Method and Apparatus for Detecting and Quantifying a Chemical Substance Employing an Optical Transmission Property of Metallic Islands on a Transparent Substrate

Номер: US20120135536A1

Автор: Alexander Vaskevich, Gregory Kalyuzhny, Israel Rubinstein

Принадлежит: Yeda Research and Development Co Ltd

A sensor for use in detecting and analyzing predetermined chemical substances is presented. The sensor comprises: a first structure configured for binding to a certain substance and comprising a substantially transparent substrate with respect to electromagnetic radiation of a predetermined wavelength range and a plurality of metallic islands deposited onto the transparent substrate and having a first spectral transmission profile with respect to the electromagnetic radiation of the predetermined wavelength range; the metallic islands comprising metallic films having a thickness selected such that binding of said certain substance to the first structure provides a change in a localized surface plasmon extinction in the metallic films being in a predetermined correlation with a change in a spectral transmission profile of the electromagnetic radiation of the predetermined wavelength range transmitted through the first structure and the substance as compared to said first spectral transmission profile, thereby enabling detection of said substance.

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Номер записи: 17

31-05-2012 дата публикации

Variable Volume Mixing and Automatic Fluid Management for Programmable Microfluids

Номер: US20120136492A1

Автор: Ahmed Mohamed Eid Amin, Han-Sheng Chuang, Mithuna Shamabhat Thottethodi, Stephen C. Jacobson, Steven T. Wereley, Terani Nadadoor Vijaykumar

Принадлежит: PURDUE RESEARCH FOUNDATION

A microfluidic arrangement including a fluid channel configured to receive a first fluid from a first inlet and a second fluid from a second inlet, and a mixer connected to the fluid channel, the mixer including a mixer channel configured to receive a volume of the first fluid and a volume of the second fluid from the fluid channel, the mixer channel defining a mixer capacity, wherein the mixer is (i) configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a mixture of the first fluid and the second fluid when the combined volume of the first fluid and the second fluid is less than the mixer capacity, and (ii) further configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a mixture of the first fluid and the second fluid when the combined volume of the first fluid and the second fluid is equal to the mixer capacity.

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Номер записи: 18

14-06-2012 дата публикации

Pathogen and particle detector system and method

Номер: US20120147370A1

Автор: Jian-Ping Jiang, John Babico, Michael Morrell

Принадлежит: Biovigilant Systems Inc

A particle detector has a sample area of cross section no in excess of about 2 mm for containing environmental fluid, a light source on one side of the sample area for directing a collimated or nearly collimated beam of light through the sample air or water so that part of the light beam will be scattered by any particles present in the air or water while the remainder remains unscattered, and a beam diverting device on the opposite side of the sample area for diverting or blocking at least the unscattered portion of the beam of light and directing at least part of the scattered light onto a detector. The detector produces output pulses in which each pulse has a height proportional to particle size and a pulse height discriminator obtains the size distribution of airborne particles detected in the air or water sample at a given time from the detector output. The detector may also include a device for discriminating between biological agents and inorganic particles.

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Номер записи: 19

21-06-2012 дата публикации

Liquid feeding system for microchip, sample detection device, and liquid feeding method for liquid feeding system for microchip

Номер: US20120156800A1

Автор: Kusunoki Higashino, Naoki Hikage, Youichi Aoki

Принадлежит: KONICA MINOLTA INC

A liquid feeding system for a microchip performs: a first liquid feeding step in which a sample liquid in a sample liquid containing section is fed in the direction to a primary containing section via a reaction field; a second liquid feeding step in which, after the first liquid feeding step, the sample liquid is fed from the primary containing section in the direction to the reaction field; and a third liquid feeding step in which, after the second liquid feeding step, the feedings of the sample liquid from and to the reaction field and the primary containing section a rear side gas-liquid boundary face of the sample liquid in the first liquid feeding step and the front side and rear side gas-liquid boundary faces of the sample liquid in the second and third liquid feeding steps do not pass through the reaction field.

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Номер записи: 20

28-06-2012 дата публикации

Apparatus and method for measuring transmittance

Номер: US20120162651A1

Автор: James Andrew Glover

Принадлежит: Real Tech Inc

A device to measure the amount of light able to transmit through a liquid. The device uses a light detector and light source mounted to a support mechanism such that the detector and light source define a path of light emitted by the light source and detected by the detector. The device uses a structure designed to surround a liquid to be tested such that the structure allows light to transmit through the structure and the liquid. An actuator engenders relative motion between the support mechanism and the structure such that at certain times the light propagating between the light source and the detector passes substantially through the structure and the liquid to be tested such that the amount of light able to transmit through the liquid is detected by the detector, and at other times the light propagates directly from the light source to the detector without passing through the structure or the liquid such that the amount of light emitted from the light source is directly detected by the detector. A microprocessor then uses the two sets of detector readings to allow the transmittance measurement of the liquid to be compensated for errors introduced by drift and fluctuations in the amount of light emitted by the light source and also by drift in the light detector and electronics. Such fluctuation and drift is very common in light sources and is due primarily to changes in temperature and imperfections in the light source itself and the power supply.

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Номер записи: 21

12-07-2012 дата публикации

Microfluidic reactor system

Номер: US20120177543A1

Автор: C. Frederick Battrell, Isaac Sprague, John Clemmens

Принадлежит: Micronics Inc

A compact device for operatively coupling a solid planar substrate, for example a glass slide, to a microfluidic circuit and performing a reaction or reactions on organic matter bound to the face of the planar substrate. Typical reactions include binding, staining and/or labeling reactions. In use, a sealed reaction chamber is formed, the chamber enclosing the organic matter and at least a part of the solid substrate. Headspace in the sealed chamber between the solid substrate is generally of microfluidic dimensions, and diaphragm pump members are used to inject, exchange and/or mix the fluids in the chamber.

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Номер записи: 22

26-07-2012 дата публикации

Test device, reaction apparatus and reactive test method

Номер: US20120190129A1

Автор: Kenichi Miyata, Kusunoki Higashino, Yasuhiro Sando

Принадлежит: KONICA MINOLTA INC

A test device having a micro flow channel including a reaction part where a reactant that is reactive to a tested chemical dispersed in a tested fluid is fixed, and at least one actuator for actuating the tested fluid to move in at least one of two opposite sides of the micro flow channel so as to homogenize a density distribution of the tested chemical in the tested fluid. The tested fluid is sent in the micro flow channel a plurality of times.

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Номер записи: 23

02-08-2012 дата публикации

Process analyzer

Номер: US20120195799A1

Автор: Aria Farjam, Bas De Heij, Kai Berggold, Rolf Uthemann, Ulrich Lundgreen

Принадлежит: HACH LANGE GMBH

A process analyzer for detection of an analyte in a liquid under analysis includes a base module and an exchangeable cartridge module. The exchangeable cartridge module comprises a sample taking device comprising a membrane configured to obtain a sample from the liquid under analysis. A first pump mechanism is configured to pump the sample away from the sample taking device. A second pump mechanism is configured to introduce a reagent into the sample. A measuring section is configured to perform a quantitative detection of the analyte in the sample. A degassing device is arranged downstream of the first pump mechanism and the second pump mechanism. The degassing device is configured to degas the sample.

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Номер записи: 24

02-08-2012 дата публикации

Three-dimensional (3d) hydrodynamic focusing using a microfluidic device

Номер: US20120196314A1

Автор: Ahmad Ahsan Nawaz, Tony Jun Huang, Xiaole Mao

Принадлежит: PENN STATE RESEARCH FOUNDATION

A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. Examples of the invention also include improved flow cytometers.

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Номер записи: 25

09-08-2012 дата публикации

Micro mixer and microfluidic chip

Номер: US20120201724A1

Автор: Gou Yanagihara, Kenichi Miyata, Kusunoki Higashino, Masashi Nishikado, Takahiro Mohri, Yasuhiro Sando

Принадлежит: KONICA MINOLTA INC

There are provided a micro mixer capable of efficiently mixing at least two types of liquids in a simple structure and a microfluidic chip provided with the micro mixer. In order to achieve the object, the micro mixer includes a minute passage through which first and second liquids are caused to flow respectively, and a mixing vessel in which a liquid injecting port caused to communicate with the minute passage is provided in a bottom part, and the liquid injecting port is provided in a shifted position from a center of the bottom part in the bottom part. Moreover, the liquid injecting port may be provided in a shifted position from a center line of the mixing vessel.

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Номер записи: 26

16-08-2012 дата публикации

Method and Apparatus for the Optical Determination of Total Organic Carbon in Aqueous Streams

Номер: US20120205547A1

Автор: Chris J. Russo, Don Jackson, Gary P. Klinkhammer, Paul H. Mcclelland

Принадлежит: ZAPS Tech Inc

A method and apparatus for the measurement of total organic carbon content in an aqueous stream is disclosed. Absorbance of electromagnetic energy by the aqueous stream is measured in an optical sample cell with pulsed light at a wavelength of 190 nm±10 nm. A value of total organic carbon from the measured absorbance is calculated without absorbance or fluorescence measurement at any other wavelength.

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Номер записи: 27

16-08-2012 дата публикации

Systems and Methods for Detection and Quantitation of Analytes Using an Oscillating Stimulus

Номер: US20120208283A1

Автор: Cristina Polonschii, Dumitru Bratu, Eugen Gheorghiu, Mihai Sorin DAVID

Принадлежит: Centrul International de Biodinamica

Described systems and methods allow the detection of and determination of a concentration of a target analyte such as a biological cell, a virus, a polypeptide, a toxin, a pesticide, a drug, a drug residue, or a DNA strand, in a fluid sample. A variable stimulus, such as an oscillating magnetic field or a light beam of oscillating intensity, is applied to the sample, inducing variations in a position or shape of a constituent of the sample, or variations in a fluorescence of the sample. Such variations produce measurable variations in electric and/or optical properties of a sensor, variations which allow the determination of the concentration of the target analyte.

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Номер записи: 28

13-09-2012 дата публикации

Devices and methods for interfacing microfluidic devices with macrofluidic devices

Номер: US20120230887A1

Автор: Piero Zucchelli

Принадлежит: SpinX Inc

The present disclosure is directed generally to devices and methods with the purpose of interfacing microfluidic devices with macrofluidic devices. Specifically, the present disclosure includes the de-

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Номер записи: 29

20-09-2012 дата публикации

Apparatus for detecting target molecules and related methods

Номер: US20120234393A1

Автор: Axel Scherer, George Maltezos, Jeremy Witzens

Принадлежит: California Institute of Technology CalTech

An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

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Номер записи: 30

20-09-2012 дата публикации

Antigen Binding Proteins

Номер: US20120237506A1

Автор: Birgit Bossenmaier, Christian Klein, Claudio Sustmann, Hubert Kettenberger, Joerg-Thomas Regula, Klaus-Peter Kuenkele, Manfred Schwaiger, Wolfgang Schaefer

Принадлежит: Hoffmann La Roche Inc

The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.

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Номер записи: 31

27-09-2012 дата публикации

System for and Method of Performing Multi-Technique Imaging

Номер: US20120241596A1

Автор: Cagri A. Savran, Khalid M. Arif

Принадлежит: PURDUE RESEARCH FOUNDATION

A system for and method of performing multi-technique imaging are disclosed. Such multi-technique imaging system includes a surface for supporting a specimen and at least two illumination sources for producing light radiation. The system also includes a plurality of reflective and refractive devices arranged to direct at least part of the light radiation from each of the at least two illumination sources to the surface such that the at least part of the light radiation from each of the at least two illumination sources illuminates substantially the same area on the surface. The system also includes a sensor configured to receive light radiation from the at least two illumination sources reflected by the specimen and/or that pass by the specimen. The system also includes a power source configured to power the at least two illumination sources and the sensor.

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Номер записи: 32

27-09-2012 дата публикации

Method and system for interaction analysis

Номер: US20120244637A1

Автор: Olof Karlsson

Принадлежит: GE Healthcare Bio Sciences AB

A method of determining one or more interaction parameters for the interaction between an analyte and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with a control analyte, C: registering the sensor response from binding of the control analyte to binding sites of the ligand, D: determining the control saturation response (R maxC ) for the interaction between the control analyte and the ligand, E: transforming the control saturation response (R maxC ) to an analyte saturation response (R maxA ) using the relative molar response contribution of the analyte and the control analyte. F: contacting the sensor surface with one or more samples containing different concentrations of the analyte, G: registering the sensor response from binding of the analyte to the binding sites, and H: fitting the registered sensor response to a predetermined interaction model using the analyte saturation response (R maxA ) to determine the interaction parameters.

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Номер записи: 33

11-10-2012 дата публикации

System and Methods for Making and Processing Emulsions

Номер: US20120258516A1

Автор: Brian Reed, John Nobile, Jonathan Schultz, Prasanna Thwar, Todd Roswech

Принадлежит: Life Technologies Corp

An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

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Номер записи: 34

25-10-2012 дата публикации

Microfluidic mixing apparatus and method

Номер: US20120269027A1

Автор: Huanming Xia, Zhiping Wang

Принадлежит: Agency for Science Technology and Research Singapore

A microfluidic mixing device for mixing at least two fluids to form a mixed fluid comprising; a first mixing chamber ( 420 ) for receiving the fluids from at least two fluid paths ( 385, 410 ); a mixing zone ( 380 ) upstream from the mixing chamber ( 420 ) having a first and second fluid path; said first and second fluid paths overlapping at first and second discreet points so as to provide mutual fluid communication between the first and second paths at said discreet points.

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Номер записи: 35

08-11-2012 дата публикации

Fluorescence detecting optical system and multi-channel fluorescence detection apparatus including the same

Номер: US20120280143A1

Автор: Joon-Ho Kim, Kak Namkoong, Kyung-Ho Kim, Won-Seok Chung

Принадлежит: SAMSUNG ELECTRONICS CO LTD

A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.

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Номер записи: 36

08-11-2012 дата публикации

Microfluidic device comprising microchannel where protrusions are formed on bottom surface

Номер: US20120282625A1

Автор: Dae Sung Hur, Eun Hee Park, Jae Jeong Kim, Jong Hyun Oh

Принадлежит: Nanoentek Inc

Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the microchannel.

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Номер записи: 37

22-11-2012 дата публикации

Process for toluene and methane coupling in a microreactor

Номер: US20120296133A1

Автор: James R. Butler

Принадлежит: Fina Technology Inc

A process for making ethylbenzene and/or styrene by reacting toluene with methane in one or more microreactors is disclosed. In one embodiment a method of revamping an existing styrene production facility by adding one or more microreactors capable of reacting toluene with methane to produce a product stream comprising ethylbenzene and/or styrene is disclosed.

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Номер записи: 38

29-11-2012 дата публикации

Microchemical nanofactories

Номер: US20120298037A1

Автор: Brian Kevin Paul, Chih-Hung Chang, Vincent Thomas Remcho

Принадлежит: Oregon State Board of Higher Education, State University

Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

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Номер записи: 39

06-12-2012 дата публикации

Microprocessing for preparing a polycondensate

Номер: US20120309956A1

Автор: Bruno Frederic Stengel, Christof Franz Kuesters, J. Brandner, W. Benzinger

Принадлежит: Cargill Inc

The present invention relates to a process for preparing polydextrose by using a microdevice. It further relates to the use of a microdevice for the polycondesation reactions.

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Номер записи: 40

13-12-2012 дата публикации

Device, fluidic module and method for producing a dilution series

Номер: US20120314528A1

Автор: Guenter Roth, Oliver Strohmeier, Roland Zengerle

Принадлежит: Albert Ludwigs Universitaet Freiburg

A device for producing a dilution series from a solution to be diluted, which contains a substance to be diluted, and a dilution solution, includes a body of rotation, a drive configured to subject the body of rotation to rotations having different rotation protocols, and a controller configured to control the drive so as to subject the body of rotation to the different rotational frequencies. A first mixing chamber and a second mixing chamber are connected via a fluidic connection which enables producing, in the first mixing chamber, a first mixture having a first dilution ratio, transferring a partial volume of the first mixture into the second mixing chamber, and there producing a second mixture having a second dilution ratio.

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Номер записи: 41

03-01-2013 дата публикации

Gas concentration calculation device and gas concentration measurement module

Номер: US20130003046A1

Автор: Tadayoshi Murakami, Toshiyuki Izawa

Принадлежит: Hamamatsu Photonics KK

A device includes a gas cell ( 10 X) configured to form an introduction space ( 11 X) into which a target gas is introduced, an infrared light source ( 20 X) disposed at one end of the gas cell ( 10 X), a modulation mirror ( 70 X) disposed at one end of the gas cell ( 10 X) and configured to reflect or transmit light emitted from the infrared light source ( 20 X), a reflecting mirror ( 60 X) configured to reflect light transmitted through the modulation mirror ( 70 X), a saturated gas chamber ( 40 X), in which a predetermined comparison gas is hermetically enclosed, disposed on an optical path of light transmitted through the modulation mirror ( 70 X), a light receiving unit ( 30 X) disposed at the other end of the gas cell ( 10 X) and configured to receive light reflected by the modulation mirror ( 70 X) and light transmitted through the modulation mirror ( 70 X) and reflected by the reflecting mirror ( 60 X) through the saturated gas chamber ( 40 X), and a calculation circuit ( 3 X) configured to calculate the concentration of the target gas based on received light energy values of the light receiving unit ( 30 X) in each case in which light is reflected or transmitted by the modulation mirror ( 70 X).

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Номер записи: 42

17-01-2013 дата публикации

Immersion probe using ultraviolet and infrared radiation for multi-phase flow analysis

Номер: US20130016336A1

Автор: Cheng-Gang Xie

Принадлежит: Schlumberger Technology Corp

A system and method for determining characteristics of a multiphase flow in a well/pipe are disclosed. The disclosed system and method use an optical immersion probe including a flow gap across which two or more types of radiation are transmitted in order to measure absorptions of two or more substances within the multiphase flow. Primarily, broadband ultraviolet (UV) and/or near infrared radiations (NIR) are utilized with the probe to gather absorption data at and/or around at least one of the water peaks and at and/or around one or more oil or oil-condensate peaks. This data may be utilized to calculate the water-cut of the multiphase flow over a wider range of gas volume fractions. Additionally, pressure ports having pressure sensors being located on the optical immersion probe for determining the impact pressures and flow rates of different phases of the multiphase flow may also be used.

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Номер записи: 43

31-01-2013 дата публикации

Plasmon sensor, and usage method and manufacturing method thereof

Номер: US20130029430A1

Автор: Hiroaki Oka, Hiroshi Kagata, Masaya Tamura, Susumu Fukushima

Принадлежит: Panasonic Corp

A plasmon sensor has a first metal layer and a second metal layer. The first metal layer has a bottom surface and a top surface configured to be supplied with an electromagnetic wave. The second metal layer has a top surface confronting the bottom surface of the first metal layer. Between the first metal layer and the second metal layer, there is provided a hollow region configured to be filled with a specimen containing a medium. Analyte capturing bodies are physically adsorbed at least one of below the first metal layer and above the second metal layer.

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Номер записи: 44

14-02-2013 дата публикации

Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom

Номер: US20130039893A1

Автор: Toan-Thang Phan

Принадлежит: CellResearch Corp Pte Ltd

The present invention relates to the generation of a mucin-producing cell using stem/progenitor cells obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucin-producing cells.

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Номер записи: 45

21-02-2013 дата публикации

Fluidic Coupler Assembly With Conical Ferrule

Номер: US20130043672A1

Автор: Anthony C. Jeannotte, Charles T. Murphy, John A. Leason

Принадлежит: Waters Technologies Corp

A fluidic coupler assembly ( 10 ) for use in a light-guided flow cell comprises a coupler body ( 12 ) having a sealing face ( 10 a ), a tubular insert such as an optical fibre ( 16 ) passing through a through bore ( 14 ) of the coupler body and through a ferrule ( 18 ) located adjacent the sealing face of the coupler body. A backing plug ( 20 ) holds the ferrule in position within the coupler body.

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Номер записи: 46

07-03-2013 дата публикации

Sensor system using a hollow waveguide

Номер: US20130058830A1

Автор: Andrei Deev, Sheng Wu, Yongchun Tang

Принадлежит: GEOISOCHEM CORP

The present application provides a method for determining one or two parameters of a sensor system for detecting a gaseous sample. The sensor system comprises a light source to generate a light beam, a hollow waveguide to receive the light beam and the gaseous sample, and a detector to detect an absorption peak of the gaseous sample, where the length and inner diameter of the hollow waveguide satisfy relationships as disclosed herein.

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Номер записи: 47

14-03-2013 дата публикации

Flow cell for measuring electromagnetic radiation absorption spectra in a continuously flowing immiscible liquid(s) or liquids with entrained gas phases

Номер: US20130061657A1

Автор: Alexey Leonidovich Moskvin, Andrey Vladimirovich Zinenkov, Arkady Samuilovich Dykman, Lubov Borisovna Drozdova, Mark Erik Nelson

Принадлежит: SABIC INNOVATIVE PLASTICS IP BV

An apparatus and method for spectral analysis of immiscible phases are disclosed. A flow cell for online absorption measurements of immiscible process phases can comprise: a body containing an inlet window and an outlet window in operable communication with a measurement instrument; and a series of partitions that divide the inside of the flow cell into three (3) or more vessels that have an inlet and an outlet, wherein the vessels are connected in series with one another. Optionally, the first vessel is equipped with a porous membrane to facilitate the separation of immiscible process phases.

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Номер записи: 48

14-03-2013 дата публикации

Methods and systems for forming boronic acids and intermediates thereof

Номер: US20130066115A1

Автор: Catherine A. MENNING, D. Wayne Blaylock, Mark V. M. Emonds

Принадлежит: DOW AGROSCIENCES LLC

Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.

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Номер записи: 49

21-03-2013 дата публикации

Method and Apparatus for a Microfluidic Device

Номер: US20130068310A1

Автор: Albert Folch, Christopher Sip

Принадлежит: University of Washington Center for Commercialization

An microfluidic device and methods for its use, where the microfluidic device comprises: (a) a porous membrane, (b) a gradient layer defining a plurality of gradient micro-channels, where the gradient layer is coupled to a top surface of the membrane, (c) a distributor layer defining a plurality of distributor micro-channels, where the distributor micro-channels are coupled to the plurality of gradient micro-channels, where the distributor layer defines at least one inlet opening and at least one outlet opening, each inlet opening and outlet opening are coupled to the plurality of distributor micro-channels, and (d) self-supporting means coupled to one or more of the porous membrane, the gradient layer and the distributor layer.

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Номер записи: 50

21-03-2013 дата публикации

Waveguide-based optical scanning systems

Номер: US20130071850A1

Автор: Reuven Duer

Принадлежит: PLC Diagnostics Inc

A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.

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Номер записи: 51

28-03-2013 дата публикации

Device for Forming Drops in a Microfluidic Circuit

Номер: US20130078164A1

Автор: Charles Baroud, Remi Dangla

Принадлежит: ECOLE POLYTECHNIQUE

The invention relates to a device ( 1 ) for forming droplets in a microfluidic circuit, the device comprising a chamber ( 3 ) containing a first fluid and defined by two opposite walls ( 10, 11 ) that diverge relative to each other in at least one given direction, and a microchannel ( 8 ) containing a second fluid and leading into a zone of said chamber ( 3 ) that is upstream relative to the given direction, the outlet of the microchannel ( 8 ) into the chamber ( 3 ) constituting an enlargement in the flow section for the second fluid, and the enlargement giving rise to droplets ( 14 ) of the second fluid forming within the first fluid.

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Номер записи: 52

28-03-2013 дата публикации

Preparation of microfluidic device on metal nanoparticle coated surface, and use thereof for nucleic acid detection

Номер: US20130078740A1

Автор: Benjamin L. Miller, Hsin-I Peng

Принадлежит: UNIVERSITY OF ROCHESTER

The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample.

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Номер записи: 53

25-04-2013 дата публикации

Microfluidic device with interconnects

Номер: US20130098481A1

Автор: Emmanuel Delamarche, Govind Kaigala, Robert Lovchik

Принадлежит: International Business Machines Corp

A microfluidic device with interconnects. The device includes a first layer; a second layer, the first layer and the second layer assembled such as to face each other; a microchannel in said second layer; a tapered conduit having a tapered portion, wherein the tapered portion is inserted in a correspondingly shaped via formed in the first layer at the level of an end of the microchannel such that fluid communication is enabled between the microchannel and the conduit, and blocked in the via by way of the assembled first layer and second layer.

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Номер записи: 54

25-04-2013 дата публикации

INTEGRATED PLASMONIC SENSING DEVICE AND APPARATUS

Номер: US20130100454A1

Автор: WALTERS Robert Joseph

Принадлежит: Integrated Plasmonics Corporation

An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels. 1. A sensor comprising:a plurality of measurement regions supporting changes in surface plasmon excitation in response to incident light at each measurement region,a plurality of photodetectors, with each photodetector connected to one or more measurement regions by plasmon vias capable of supporting guided plasmons, andwherein the plurality of measurement regions and plurality of photodetectors are monolithically integrated and together form an integrated sensor capable of producing electrical signals in response to molecular recognition events at each measurement region.2. A sensor in accordance with wherein the plurality of photodetectors together comprise an image sensor formed in a semiconductor substrate and the plurality of measurement regions form part of a plasmonic backplane located between a fluid chamber and the plurality of photodetectors.3. A sensor in accordance with wherein more than one of the plurality of photodetectors are connected to one of the plurality of measurement regions by one or more plasmon vias.4. A sensor in accordance with wherein more than one of the plurality of measurement regions are connected to one of the plurality of photodetectors by one or more plasmon vias.5. A sensor in accordance with wherein at least some of the plurality of measurement regions are laterally offset from and ...

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Номер записи: 55

02-05-2013 дата публикации

Architectural layout for dilution with reduced wastage in digital microfluidic based lab-on-a-chip

Номер: US20130105319A1

Автор: Bhargab B. Bhattacharya, Krishnendu Chakrabarty, Sudip Roy

Принадлежит: Indian Statistical Inst

Systems and methods are provided for producing fluids with desired concentration factors. According to one embodiment, an arrangement of digital microfluidic (DMF) based electrode platforms are provided. The arrangement may be configured to carry out a sequence of mix steps that may demand storage of resultant fluid mixtures produced in intermediate mix steps. Such sequences of mix steps may be desirable as a result of the decreased demand for initial fluid samples, and reduced wastage.

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Номер записи: 56

09-05-2013 дата публикации

Dilution method for digital microfluidic biochips

Номер: US20130115703A1

Автор: Bhargab B. Bhattacharya, Krishnendu Chakrabarty, Sudip Roy

Принадлежит: Indian Statistical Inst

Systems and methods are provided for producing fluids with desired concentration factors. According to one embodiment, a sequence of mix steps comprises mixing a resultant solution of a preceding mix step with one of the input solutions of the preceding mix step depending on a concentration factor of the resultant solution. If the concentration factor of the resultant solution is higher than the target concentration factor, then the resultant solution is mixed with the input solution having the lower concentration factor. If the concentration factor of the resultant solution is lower than the target concentration factor, then the resultant solution is mixed with the input solution having the higher concentration factor.

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Номер записи: 57

16-05-2013 дата публикации

Optical phase device, method and system

Номер: US20130120750A1

Автор: Guan Jingyi, Lv Zhiting, Wan Yuhang, ZHAO XIN, Zheng Zheng

Принадлежит: BEIHANG UNIVERSITY

The invention provides an optical phase device with its application method and system. The optical phase device consists of a transparent dielectric substrate, a multilayer stack of dielectrics and a buffer layer. The refractive index of the transparent dielectric substrate, the multilayer stack of dielectrics and the buffer layer are all larger than that of the external medium. For the wavelength of the incident beam, the optical phase device has a phase variation in the angular range [α, β] and the critical angle for total reflection on the interface between the buffer layer and the external medium adjacent to the buffer layer is γ, γ>β. Our invention of the optical device has both low loss and large phase variation, which leads to a large Goos-Hanchen shift. As a dispersion compensation component, it can produce bigger and tunable dispersion, and different dispersion compensations can be got by adjusting the operating angle or parameters in the structure.

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Номер записи: 58

23-05-2013 дата публикации

Mixing Device and Mixing Method

Номер: US20130127957A1

Автор: GULVIN PETER MICHAEL, Hays Andrew W, Lin Pinyen, Mantell David Allen

Принадлежит: XEROX CORPORATION

A mixing method and device are disclosed. The mixing method includes providing a drop generating device including a first drop ejector, a second drop ejector and a collector. The mixing method also includes ejecting a plurality of drops of a first reactant from the first drop ejector and ejecting a plurality of drops of a second reactant from the second drop ejector and collecting the drops with the collector. 1. A mixing method claim 14 , comprising: providing the mixing device of ; ejecting a plurality of drops of a first reactant from the first drop ejector; ejecting a plurality of drops of a second reactant from the second drop ejector; and collecting the drops with the collector.2. The mixing method of claim 1 , wherein the first drop ejector includes a first array of ejectors and wherein the second drop ejector includes a second array of ejectors.3. The mixing method of claim 1 , further including at least partially mixing the plurality of drops of the first reactant and the plurality of drops of the second reactant after being ejected by the drop ejectors and before contacting the collector.4. The mixing method of claim 1 , wherein at least one of the first drop ejector and the second drop ejector are configured to cause the plurality of drops of the first reactant and the plurality of drops of the second reactant to at least partially mix before contacting the collector.5. The mixing method of claim 1 , further including directing at least one of the plurality of drops of the first reactant towards at least one of the plurality of drops of the second reactant.6. The mixing method of claim 1 , wherein the collector includes a drum claim 1 , the drum being configured to receive the plurality of drops of the first reactant and the plurality of drops of the second reactant.7. The mixing method of claim 1 , further including providing a third drop ejector disposed in mechanical cooperation with the mixing device claim 1 , the third drop ejector configured to ...

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Номер записи: 59

23-05-2013 дата публикации

MICRO-CHANNEL REACTOR FOR PRODUCING SYNTHETIC NATURAL GAS

Номер: US20130129584A1

Автор: Hwang Kyung Ran, Kim Dong Kook, KIM Tae Hwan, Lee Chun Boo, Lee Sung Wook, Park Jong Soo, Ryi Shin Kun

Принадлежит: KOREA INSTITUTE OF ENERGY RESEARCH

The present invention relates to a micro-channel reactor for producing synthetic natural gas, and more particularly, to a micro-channel reactor for producing synthetic natural gas containing methane gas from synthetic gas, including a porous nickel plate catalyst part. 1. A micro-channel reactor for producing synthetic natural gas containing methane gas from synthetic gas , comprising a porous nickel plate catalyst part.2. A micro-channel reactor for producing synthetic natural gas containing methane gas from synthetic gas , the micro-channel reactor comprising:an upper plate including a reactant introduction pipe and a cooling fluid discharge pipe formed at different positions on an upper surface thereof, the reactant introduction pipe introducing synthetic gas containing hydrogen and carbon monoxide therethrough;a lower plate including a cooling fluid introduction pipe and a product discharge pipe formed at different positions on a lower surface thereof, the product discharge pipe discharging a product containing methane gas produced after reaction therethrough;upper and lower heat exchangers each provided between the upper and lower plates and each including a reactant introduction through-hole, a cooling fluid discharge through-hole, a product discharge through-hole, and a cooling fluid introduction through-hole formed at each corner thereof, and a micro-channel; anda porous nickel plate catalyst part provided between the upper and lower heat exchangers, including a cooling fluid discharge through-hole and a cooling fluid introduction through-hole, and including a porous nickel plate.3. The micro-channel reactor of claim 2 , wherein each of the reactant introduction pipe and the cooling fluid discharge pipe included in the upper plate and the cooling fluid introduction pipe and the product discharge pipe included in the lower plate is formed at a position corresponding to that of each of the through-holes included in the heat exchangers claim 2 , the cooling ...

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Номер записи: 60

30-05-2013 дата публикации

Co-current mixer, apparatus, reactor and method for precipitating nanoparticles

Номер: US20130136687A1

Автор: Christopher James Tighe, Jawwad Darr, Robert Gruar

Принадлежит: UCL BUSINESS LTD

A high pressure tubular reactor for production of nanoparticles by precipitation has unidirectional fluid flows of precursor and supercritical water directed from inner and outer coaxial inlets to an outlet via a reaction zone immediately downstream of the inlets. The inner inlet is for supercritical fluid, and the outer inlet is for a precursor.

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Номер записи: 61

30-05-2013 дата публикации

Novel method of preparing secondary amine compound using microflow reactor

Номер: US20130137900A1

Автор: Han-Seo Moon, Jin-Hyun Jeong, Liu-Lan Shen, Yong-Sung Choi

Принадлежит: Industry Academic Cooperation Foundation of Kyung Hee University

Disclosed is a novel method of preparing a secondary amine compound using a microflow reactor. According to the method, a primary amine compound and a halide compound are allowed to react with each other in the microflow reactor, such that the production of a tertiary amine compound or an ammonium salt is minimized, whereby the secondary amine compound is efficiently prepared.

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Номер записи: 62

06-06-2013 дата публикации

Spfs sensor equipped with mechanism purifying non-specifically adsorptive contaminants

Номер: US20130143332A1

Автор: Masanori Tsukagoshi, Noriaki Yamamoto, Takatoshi KAYA

Принадлежит: KONICA MINOLTA INC

[Object] It is an object of the invention to provide a sensor area which can suppress a decrease in assay signal and an increase in assay blank in an SPFS measurement. [Solution] An SPFS sensor chip of the invention includes a purification area and a sensor area arranged upstream and downstream, respectively, relative to each other along a flow direction in a channel for surface plasmon-field enhanced fluorescence spectroscopy [SPFS].

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Номер записи: 63

06-06-2013 дата публикации

Device And Method For The Preparation Of Radiochemical Compounds

Номер: US20130144051A1

Автор: Howitz Steffen, Mueller Marco

Принадлежит:

The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein; the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. 1. A device for the preparation of radiochemical compounds comprising: the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module;', 'the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and', 'at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module., 'at least a reaction module, a dosing module, and a storage module, wherein;'}2. The device according to claim 1 , wherein that the reaction vessel of the reaction module has an internal volume of 10 nl to 20 claim 1 ,000 μl.3. The device according to claim 1 , wherein that the reaction module has a heating ...

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Номер записи: 64

06-06-2013 дата публикации

Device for the synthesis of radio-labeled compounds

Номер: US20130144052A1

Автор: Marco Mueller

Принадлежит: ABX advanced biochemical compounds GmbH

The invention relates to a device for the synthesis of radio-labeled compounds, which comprises a reaction vessel for reacting a precursor compound having protective groups with a radioactive isotope to obtain a first reaction product; a first cartridge for hydrolyzing the protective groups of the first reaction product to obtain a second reaction product; and a second cartridge for purifying the second reaction product, wherein the reaction vessel, the first cartridge, and the second cartridge are connected to each other via pipelines. Here it is provided that the first cartridge contains 801 to 1200 mg of a solid carrier and/or the reaction vessel is a reaction vessel made of a temperature-resistant plastic with the plastic having a temperature resistance of at least 120° C.

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Номер записи: 65

20-06-2013 дата публикации

Flow passage structure

Номер: US20130153071A1

Автор: Koji Noishiki, Makoto Nishimura, Takeshi Yamashita, Tatsuo Yoshida

Принадлежит: Kobe Steel Ltd

A flow passage structure having a plurality of flow passageways therein includes a first junction portion for joining a first fluid introduced into a first inlet path and a second fluid introduced into a second inlet path, a first joined fluid flow passage through which a fluid made by joining both the fluids flows, a branch portion for dividing the fluid flowing in the first joined fluid flow passage into two fluids, a first branch path through which one of the two divided fluids flows, and a second branch path through which the other flows, wherein a corresponding diameter of the first branch path and a corresponding diameter of the second branch path in each of the passageways are smaller than a corresponding diameter of the first joined fluid flow passage in the passageway.

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Номер записи: 66

27-06-2013 дата публикации

PLASMON SENSOR

Номер: US20130163001A1

Автор: Hashimotodani Kiyoshi, Kagata Hiroshi, Tamura Masaya

Принадлежит: Panasonic Corporation

A plasmon sensor includes a supporter, a first metal layer on a lower surface of the first supporter, and a second metal layer having an upper surface facing a lower surface of the first metal layer. A hollow space is provided between the first and second metal layers, and is configured to be filled with a test sample containing a medium. The area of the first metal layer is smaller than the area of the upper surface of the supporter. The supporter has a region having hydrophilic property and facing and contacting the hollow space. This the plasmon sensor has a small size and a simple structure. 1. A plasmon sensor comprising:a first supporter having a lower surface;a second supporter having an upper surface;a first metal layer having a lower surface and an upper surface which is configured to receive electromagnetic wave and disposed on the lower surface of the first supporter; anda second metal layer having a lower surface and an upper surface which faces the lower surface of the first metal layer, the lower surface of the second metal layer being disposed on the upper surface of the second supporter,wherein a hollow space is provided between the first metal layer and the second metal layer, and is configured to be filled with a test sample containing a medium,wherein one of the first supporter and the second supporter has hydrophilic property,wherein an area of the first metal layer is smaller than an area of the lower surface of the first supporter in a case that the first supporter has hydrophilic property, andwherein an area of the second metal layer is smaller than an area of the upper surface of the second supporter in a case that the second supporter has hydrophilic property.2. The plasmon sensor according to claim 1 ,wherein the lower surface of the first supporter has a first region facing the hollow space in a case that the first supporter has hydrophilic property, andwherein the upper surface of the second supporter has a second region facing the hollow ...

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Номер записи: 67

04-07-2013 дата публикации

Versatile surface plasmon resonance analyzer with an integral surface plasmon resonance enhanced fluorescence mode

Номер: US20130169954A1

Автор: Ernest F. Guignon, George N. Gibson, Michael T. Reilly

Принадлежит: Ciencia Inc

An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.

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Номер записи: 68

18-07-2013 дата публикации

Microfluidic device, microfluidic dosing system and method for microfluidic flow measurement and dosing

Номер: US20130183209A1

Автор: Martin Richter, Sebastian KIBLER

Принадлежит: Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV

A microfluidic device for detecting a flow parameter, includes a channel configured within a base body, the channel including a first inlet for feeding a first fluid and a second inlet for feeding a second fluid so as to form a fluid stream having the first and second fluids within the channel, and further including an output for providing the fluid stream on the output side, a first feeder including a micropump associated with the first inlet for selectively feeding the first fluid to the channel, a second feeder associated with the second inlet for feeding the second fluid to the channel; and a detector for detecting, on the basis of a different physical property of the first fluid and the second fluid within the channel, a measurement value dependent on a current flow parameter of the first or second fluid.

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Номер записи: 69

18-07-2013 дата публикации

Microfluidic devices

Номер: US20130183659A1

Автор: Darren R. Link, David Marran, Jonathan M. Rothberg, Michael Weiner

Принадлежит: Raindance Technologies Inc

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

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Номер записи: 70

25-07-2013 дата публикации

OPTICAL BIOSENSOR REFERENCING METHOD

Номер: US20130189797A1

Автор: Quinn John Gerard

Принадлежит: FLIR SYSTEMS, INC.

A referencing method for an optical biosensor system using a single sensing region is provided. The method involves limiting the ligand immobilized in a single sensing region to only a portion thereof. In one embodiment, this is accomplished by selectively deactivating a portion of the sensing surface to prevent immobilization of ligand to that portion. As a result, a reference response can be recorded in the same sensing region as a molecular interaction response. Thus, the bulk refractive index can be accurately accounted for in measuring the kinetics of a molecular interaction. 1. A method for providing a reference bulk refractive index response and a binding response in a sensing region defined along a channel in a flow cell of a biosensor system comprising the steps of:injecting a first sample through a first input port at a first end of the sensing region wherein a second exit port at a second end of the sensing region is open and a first exit port at the first end of the sensing region is closed such that the first sample is caused to flow from the first end of the sensing region to the second end of the sensing region, wherein the first sample comprises an activating agent sufficient to permit immobilization of a ligand;terminating the injection of the first sample;injecting a second sample at a flow rate through the first input port, wherein the first exit port is opened and the second exit port is closed;modifying the flow rate of the second sample in a manner sufficient to cause the second sample to contact a first portion of the sensing region thereby defining a second portion of the sensing region that is not contacted by the second sample, wherein the second sample comprises a deactivating agent sufficient to render the first portion unable to immobilize the ligand;terminating the injection of the second sample;injecting a third sample comprising a ligand through the first input port with the second exit port open and the first exit port closed such ...

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Номер записи: 71

01-08-2013 дата публикации

Suspended-slurry reactor

Номер: US20130197109A1

Автор: Karim M. Ayman, Paul H. Humble, Ward E. Tegrotenhuis, Yong Wang

Принадлежит: Battelle Memorial Institute Inc

An apparatus for generating a large volume of gas from a liquid stream is disclosed. The apparatus includes a first channel through which the liquid stream passes. The apparatus also includes a layer of catalyst particles suspended in a solid slurry for generating gas from the liquid stream. The apparatus further includes a second channel through which a mixture of converted liquid and generated gas passes. A heat exchange channel heats the liquid stream. A wicking structure located in the second channel separates the gas generated from the converted liquid.

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Номер записи: 72

29-08-2013 дата публикации

Microbubble optical resonator

Номер: US20130219970A1

Автор: Mikhail Sumetsky

Принадлежит: OFS FITEL LLC

An optical microresonator is configured as an optical microbubble formed along a section of an optical microcapillary. The curvature of the outer surface of the microbubble creates an optical resonator with a geometry that encourages the circulating WGMs to remain confined in the central region of the bubble, creating a high Q optical resonator. The resonator may be tuned by modifying the physical properties of the microbubble, allowing the resonator to be used as an optical filter. The resonator may also be used as a sensor or laser by introducing the material to be sensed (or the active laser material) into the microcapillary along which the microbubble is formed.

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Номер записи: 73

29-08-2013 дата публикации

Three-dimensional digital microfluidic system

Номер: US20130220810A1

Автор: Gary Chorng-Jyh Wang

Принадлежит: Individual

A three-dimensional digital microfluidic system comprises a first plate with a first electrode, a second plate with a second electrode, and a microfluidic drop in between the first and the second electrode. The electrodes are able to be actuated in sequence such that the microfluidic drop is able to be transported. A bridge plate is able to be included.

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Номер записи: 74

29-08-2013 дата публикации

Spectrophotometer

Номер: US20130222789A1

Автор: Hideyuki Akiyama, Shigeru Matsui, Shuhei Yamamura, Yoshisada Ebata

Принадлежит: Hitachi High Technologies Corp

In a spectrophotometer of the single-beam type, highly stable transmission and absorption spectra can be obtained with a high SNR while drifting is suppressed and for a long time even when the amount of light from the light source is varied over time. The spectrophotometer includes: a light source; a sample cell; a polychromator that generates a transmission spectrum of a sample in the sample cell by dispersing a portion of light from the light source that has passed through the sample into a plurality of spectral components; an image sensor that detects the transmission spectrum of the sample; a light source monitoring photodetector that detects a portion of the light from the light source that has not passed through the sample cell; and an operation unit that corrects the transmission spectrum of the sample by using an output signal from the light source monitoring photodetector.

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Номер записи: 75

29-08-2013 дата публикации

MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE

Номер: US20130225791A1

Автор: Desai Amit V., Kenis Paul J.A., Önal Birce C., Reichert David E., Wheeler Tobias D., Zeng Dexing

Принадлежит: WASHINGTON UNIVERSITY IN ST. LOUIS

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex. 1. A method of preparing a radiolabeled complex , the method comprising:flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, the downstream mixing portion including one or more passive mixing elements;flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion;passively mixing the ligand solution and the radiometal solution while in the downstream mixing portion to form a mixed solution and to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator; andcompleting the chelation reaction to form a radiolabeled complex.2. The method of claim 1 , further comprising claim 1 , prior to flowing the radiometal solution through the downstream mixing portion of the microchannel claim 1 , flowing a precursor radiometal solution comprising the metallic radionuclide through an upstream mixing portion of the microchannel claim 1 , the upstream ...

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Номер записи: 76

12-09-2013 дата публикации

DIAGNOSTIC INSTRUMENT AND FLOW PROCESS

Номер: US20130234053A1

Автор: Thomas Michael A, Thomas Richard A

Принадлежит: BECKMAN COULTER BIOMEDICAL, LLC.

A diagnostic instrument is disclosed. The diagnostic instrument may have a highly efficient probe washer station and/or may be able to sense whether there is a tube septum on a specimen tube to be sampled. The instrument may also be able to determine where the bottom of the tube is located. The probe washer station may have a flow of saline that is used to wash both the internal cavity and the external circumference of the probe. 120.-. (canceled)21. A flow cytometer comprising:a laser beam positioned to excite sample particles in a sensing zone;an aperture that directs a flow of the sample particles through the sensing zone where the sample particles are interrogated by the laser beam, the aperture having a cross-sectional size; anda flow cytometer filtration system including a filter having multiple holes with cross sectional sizes that are less than or equal to the cross-sectional size of the aperture, wherein the filter is located in an area of the flow cytometer having a fluid velocity of less than 200 microliters per minute.22. The flow cytometer of claim 21 , further comprising a sample injector located in the area of the flow cytometer having a fluid velocity of less than 200 microliters per minute.23. The flow cytometer of claim 22 , further comprising a backflushing system claim 22 , wherein the filter is positioned in the flow cytometer at a location where the filter can be back flushed at a high fluid velocity of greater than 200 microliters per minute.24. The flow cytometer of claim 23 , wherein the backflushing system further comprises an automatic clog detecting system.25. The flow cytometer of claim 21 , wherein the aperture has a cross sectional shape selected from: a square claim 21 , a rectangle claim 21 , and an equilateral triangle.26. The flow cytometer of claim 25 , wherein the cross-sectional size of the aperture is from 100 to 300 microns per side.27. The flow cytometer of claim 26 , wherein the aperture has a length greater than 1000 ...

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Номер записи: 77

19-09-2013 дата публикации

Polymeric device suitable for ultraviolet detection

Номер: US20130240747A1

Автор: Hanno Ehring

Принадлежит: GE Healthcare Bio Sciences AB

The present invention relates to a flow cell ( 10 ) comprising a fluid inlet ( 16 ) and a fluid outlet ( 18 ) separated by a sample flow-through chamber ( 12 ) comprising at least one UV-transparent window ( 22 ′), wherein the at least one UV-transparent window ( 22 ′) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.

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Номер записи: 78

19-09-2013 дата публикации

Device for Reading Assay Results on Test Carrier

Номер: US20130242308A1

Автор: "Zhan Yingan", Gao Fei, Liu Wei, Wu Yinfei

Принадлежит: ABON Biopharm (Hangzhou)Co., Ltd.

A device for reading an assay test result on a test carrier comprises: a light-emitting element () for emitting and irradiating light onto corresponding one or more zones of the test carrier (); a light-blocking element () for blocking the light mirror-reflected by the test carrier () from being irradiated on a photodetector (); and a window (), through which the light emitted from the light-emitting element () is irradiated onto the corresponding zones of the test carrier (). In one preferred embodiment, the positions of the light-emitting element (), the light-blocking element and the window () meet the function of S*S−S*SS where S represents the vertical distance between the light-emitting element and the window; S represents the vertical height of the light-blocking element; S represents the vertical distance between the light-blocking element and the light-emitting element; and S represents the length of the window. 1. A device for reading an assay test result on a test carrier , comprising:a light-emitting element, for emitting and irradiating light onto corresponding one or more zones of the test carrier; anda light-blocking element, for blocking the light mirror-reflected by the test carrier from being irradiated on a photodetector.2. The device according to claim 1 , wherein the device further comprises a window through which the light emitted from the light-emitting element is irradiated onto the test carrier.3377211237. The device according to claim 2 , wherein positions of the light-emitting element claim 2 , the light-blocking element and the window meet a function of S≧2×S−S×S÷S claim 2 , where S represents a vertical distance between the light-emitting element and the window; S represents a vertical height of the light-blocking element; S represents a vertical distance between the light-blocking element and the light-emitting element; and S represents a length of the window.437721. The device according to claim 3 , wherein the positions of the light- ...

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Номер записи: 79

03-10-2013 дата публикации

Microfluidic component, reactor comprising a plurality of such components, and method for producing same

Номер: US20130255822A1

Автор: Martin Wichert, Silvio Kraus

Принадлежит: INSTITUT FUER MIKROTECHNIK MAINZ GMBH

A microfluidic component made of a metal sheet having a structure which includes a closed fluid line and which is formed of a structured surface of a first section of the metal sheet and an adjoining structured or unstructured surface of a second section of the metal sheet, wherein the metal sheet is folded such that the sections integrally connected to each other are located on top of each other in a surface-parallel manner. The metal sheet further includes at least one third section having a contoured edge and is moreover folded such that the third section is also supported in a surface-parallel manner and the contoured edge forms a first wall section and the adjoining structured or unstructured surface of the first or second section forms a second wall section of an open fluid line. A microfluidic reactor comprising a plurality of such microfluidic components and a method for producing such components.

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Номер записи: 80

03-10-2013 дата публикации

Micro-Reactor System Assembly

Номер: US20130259768A1

Автор: Bieler Nikolaus, Forbert Rainald, Roberge Dominique, Zimmermann Bertin

Принадлежит: Lonza AG

A micro-reactor system assembly comprises a stack of at least n process modules (-), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (A, B, A, A, A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules () made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (A, A) for accommodating and guiding a heat exchange fluid, wherein each process module (-) is sandwiched between two adjacent heat exchange modules (). 1. A module for a stacked arrangement , micro-reactor system assembly , the module comprising a first plate , a second plate and a structured intermediate plate sandwiched between said first plate and said second plate , said intermediate plate having a fluid passage formed therein , said fluid passage extending between a fluid inlet port and a fluid outlet port for accommodating and guiding a fluid.2. A module according to claim 1 , wherein said intermediate plate is a unitary plate having said fluid passages formed therein.3. A module according to claim 2 , wherein said fluid passages open on opposite surfaces of said intermediate plate and are bounded by said first and second plates.4. A module according to claim 1 , wherein said fluid passage comprises a flat passage including curved and/or straight parts to enable a flow of fluid along a tortuous path claim 1 , said flat passage having a width/height ratio in the range of 1:4 to 1:50.5. A module according to claim 1 , wherein said module is a heat exchange module comprising said first plate claim 1 , said second plate and said structured intermediate plate sandwiched between said first plate and said second plate claim 1 , said first plate having a heat exchange fluid inlet port communicating with said fluid passage and said second plate having a heat exchange fluid outlet port communicating with said fluid passage. ...

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Номер записи: 81

24-10-2013 дата публикации

Flow cells for high density array chips

Номер: US20130281305A1

Автор: Anthony Delacruz, Bill J. Peck, Daniel West, Mark Fuller

Принадлежит: Complete Genomics Inc

Biochemical flow cells having sealed inlets and outlets are provided for performing high-volume assays on macromolecules. In one example embodiment, a flow cell with detachable inlet and outlet connectors comprises an inlet manifold, a coverslip, and a substrate disposed below the coverslip to form a reaction chamber, where the substrate is disposed to partially cover the inlet manifold such that a slit is formed along an entire edge of the substrate where fluids can flow from the inlet manifold through the slit, around substantially the entire edge of the substrate, and into the reaction chamber at equalized pressure and without bubbles. In another embodiment, a flow cell comprises an outlet manifold, two or more flow regions each connected to its own loading port via its own flow distribution funnel, each loading port connected to the outlet manifold, and plugs in a wall of the outlet manifold opposite each loading port, such that when a plug is absent from the wall of the outlet manifold, a loading tip may be inserted in its place, passing through the outlet manifold and connecting directly to a loading port.

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Номер записи: 82

07-11-2013 дата публикации

Interactive variable pathlength device

Номер: US20130293894A1

Автор: Craig Harrison, I-Tsung Shih, Mark Salerno

Принадлежит: Craig Harrison, I-Tsung Shih, Mark Salerno

This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

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Номер записи: 83

07-11-2013 дата публикации

Sensing Device

Номер: US20130293896A1

Автор: Akiyama Shoji, Fujimaki Makoto, Nagata Kazutoshi

Принадлежит:

[Problem] To provide a small-sized, stable, and highly sensitive detection device by achieving an optical system which is the most suitable for an optical waveguide mode sensor using a spectral measurement method. 1. A detection device , comprising:a detection plate in which a silicon layer and a silicon oxide layer are arranged in this order on a silica glass substrate;an optical prism which is optically adhered to a surface of the silica glass substrate of the detection plate, where the surface is not provided with the silicon layer and the silicon oxide layer;a light-irradiation unit configured to irradiate light to the detection plate through the optical prism and arranged so that light is incident on the optical prism with a fixed incident angle; anda light-detection unit configured to detect intensity of reflected light reflected from the detection plate,wherein the detection device detects a change in dielectric constant in the proximity of the surface of the silicon oxide layer of the detection plate by detecting a change in property of the reflected light, andwherein in the optical prism, an angle between an incident surface on which light irradiated from the light-irradiation unit is incident and an adhesion surface which adheres to the detection plate is 43° or less.2. The detection device according to claim 1 , wherein the light-irradiation unit irradiates light in parallel with an in-plane direction of the adhesion surface.3. The detection device according to claim 1 , wherein the silicon layer is formed from single crystal silicon.4. The detection device according to claim 1 , wherein an interface roughness between the silicon layer and the silicon oxide layer is 0.5 nm or less as a RMS value.5. The detection device according to claim 1 , wherein the light-irradiation unit comprises a light source claim 1 , a collimator configured to collimate light irradiated from the light source to form collimated light claim 1 , and a polarizing plate configured to ...

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Номер записи: 84

07-11-2013 дата публикации

Radiochemical Synthesis Apparatus Using Spatial Temperature Manipulation

Номер: US20130294984A1

Автор: Jianzhong Zhang

Принадлежит: Individual

A compact and flexible apparatus that may be used to carry out multistep chemical or radiochemical synthesis is disclosed. Radiochemical tracers may be synthesized through a spatial temperature manipulation approach. The reaction vessel and the reagent vials can be removed after a single use, suggesting the apparatus can be used multiple times a day.

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Номер записи: 85

28-11-2013 дата публикации

Test chip and test chip unit incorporated with test chip

Номер: US20130312546A1

Автор: Shigeru Wada

Принадлежит: KONICA MINOLTA INC

The present invention is characterized in being provided with a chip main body, which is provided with a flow channel having the end portion thereof opened in the surface, and a sheet-like sealing member, which brings the inside of the flow channel into a hermetically closed state by covering at least the opening in the surface of the chip main body. The present invention is also characterized in that in the sealing member, a plurality of sheets are laminated, said sheets including a first sheet, which has ductility and elasticity such that the first sheet can be penetrated by means of a nozzle member, and a second sheet having ductility lower than that of the first sheet, the sheets adjacent to each other are bonded with an adhesive agent or a cohesive agent, and that the second sheet is positioned further toward the chip main body side than the first sheet.

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Номер записи: 86

12-12-2013 дата публикации

MICRO-FLUIDIC DEVICE

Номер: US20130330246A1

Автор: Stemmet Charl P.

Принадлежит: CHEMTRIX B.V.

The present invention relates to a micro-fluidic device comprising a process channel having a top wall, a bottom wall and side walls, the process channel having a height between 0.2 mm and 3 mm, a width between 1.0 and 50 mm and support means within said process channel. The support means extends between the bottom wall and the top wall of the process channel in a direction substantially perpendicularly to the top wall. The micro-fluidic device comprises at least one heat exchange means parallel to the process channel and optionally comprises a static mixing element. The present invention further relates to a kit of parts and a micro-fluidic system comprising such micro-fluidic devices. 11277aab. A micro-fluidic device () comprising a process channel () having a top wall , a bottom wall and side walls , the process channel having a height between 0.2 mm and 3 mm , a width between 1.0 and 50 mm and support means ( , ) within said process channel , the support means extending between the bottom wall and the top wall of the process channel in a direction substantially perpendicularly to the top wall , the micro-fluidic device comprising at least one heat exchange means parallel to the process channel.2. The micro-fluidic device according to claim 1 , wherein the volume of the support means is preferably 20-75 vol % claim 1 , more preferably 30-65 vol % and even more preferably 40-60 vol % claim 1 , of the sum of the volume in which a fluid can flow in the process channel and the volume of the support means in the process channel.3. The micro-fluidic device according to claim 1 , wherein the process channel comprises between 1 and 50 micro-channels having a height of between 0.2 mm and 3 mm and a width between 0.1 mm and 5 mm claim 1 , the support means being wall members of the micro-channels claim 1 , and wherein optionally the length of the process channel is between 0.1 and 5 m.4. The micro-fluidic device according to claim 1 , wherein the process channel has a ...

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Номер записи: 87

12-12-2013 дата публикации

Method of patterning self-organizing material, patterned substrate of self-organizing material and method of producing the same, and photomask using patterned substrate of self-organizing material

Номер: US20130330674A1

Автор: Hitoshi Tabata, Ken-Ichiro Nakamatsu, Shinji Matsui, Tomoji Kawai, Toshihito Ohtake

Принадлежит: Individual

A method for performing micro fabrication includes using, as a photomask, a self-organizing material-patterned substrate which is soluble in an organic solvent. A method for emitting light includes emitting the light in a pattern of a nucleic acid which is a self-organizing material immobilized on a self-organizing material-patterned substrate. An immobilization layer containing a binding material capable of binding to a self-organizing material is formed on a substrate. Then this immobilization layer is patterned by transferring a protrusion and recess pattern formed in a mold thereto by the imprint process. The self-organizing material is supplied onto the side having the protrusion and recess pattern of the immobilization layer transferred thereto. Thus, the self-organizing material is immobilized according to the protrusion and recess pattern of the immobilization layer owning to the self-organizing ability of the material per se and the binding ability of the binding material contained in the immobilization layer.

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Номер записи: 88

12-12-2013 дата публикации

SURFACE PLASMON RESONANCE SENSOR

Номер: US20130330838A1

Автор: Lipson Ariel, LIPSON Doron, Lipson Stephen G., Nimri Shay, Notcovich Ariel G., RAN Boaz

Принадлежит: Bio-Rad Laboratories Inc.

An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen. 1. A surface plasmon resonance (SPR) system using a ligand , the system comprising:a) a thin conducting layer suitable for SPR formed on a transparent substrate, the conducting layer comprising a plurality of electrodes;b) at least one flow channel crossing the electrodes at crossover regions;c) a power supply connected to the electrodes, and differently electrifying the electrodes at two different cross-over regions, such that the ligand flowing through the flow channel is attracted to and immobilized on the electrode at one of the cross-over regions, and repelled by and substantially prevented from immobilizing on the electrode at the other of the cross-over regions; andd) a photosensitive surface that generates SPR signals in response to light reflected from the crossover region at which the ligand is immobilized, that can be used to determine an SPR parameter, and generates reference SPR signals in response to light reflected from the crossover region at which the ligand is prevented from immobilizing, that can be used to normalize and correct the SPR signals from the crossover region at which the ligand is immobilized.2. A system according to ...

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Номер записи: 89

19-12-2013 дата публикации

Large area, low f-number optical system

Номер: US20130334407A1

Автор: Donald Francis Perrault, JR., Johnathan Charles Sharpe

Принадлежит: Cytonome ST LLC

Large area, low f-number optical systems, and microfluidic systems incorporating such optical systems, are disclosed. Large area, low f-number optical systems may be used to collect light from plurality of micro channels associated with a plurality of flow cytometers. The optical systems may be configured to collect light from a source area having an object lateral length or width within a range of 25 mm and 75 mm, configured to have an f-number within a range of 0.9 to 1.2, and configured to have a working distance within a range of 10 mm to 30 mm.

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Номер записи: 90

19-12-2013 дата публикации

Microfluidic device for high-throughput cellular gradient and dose response studies

Номер: US20130337486A1

Автор: Alexander Groisman, Andre Levchenko, Saurabh Paliwal

Принадлежит: JOHNS HOPKINS UNIVERSITY, UCSD Tech Transfer Office

The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a lest chamber having a depth flanked by flow-through channels having a deeper depth. Flow of two different fluids through the flow-through channels results in the creation of a gradient by diffusion across the test chamber having essentially no flow.

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Номер записи: 91

26-12-2013 дата публикации

Sealed fluidic component comprising a composite material of different paek materials

Номер: US20130341260A1

Автор: Bernhard Dehmer

Принадлежит: AGILENT TECHNOLOGIES INC

A sealed fluidic component ( 280 ) for use in a fluidic flow path is made by providing a composite material ( 300 ) comprising a first material ( 305 ) and a second material ( 310 ), wherein the first material ( 305 ) and the second material ( 310 ) are different PAEK materials with the first material ( 305 ) having a lower melting point than the second material ( 310 ). The composite material ( 300 ) is heated in order to provide a sealing by the first material ( 305 ).

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Номер записи: 92

26-12-2013 дата публикации

NON-SCANNING SPR SYSTEM

Номер: US20130344623A1

Автор: Barak Itay, RAN Boaz

Принадлежит: Bio-Rad Laboratories Inc.

A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: 2. A system according to claim 1 , wherein the detector comprises a plurality of detector elements claim 1 , arranged on the detector in a one-dimensional array claim 1 , and the different responses of the detector to light received at different locations is due to a different response of the detector to light received by different detector elements.3. A system according to claim 1 , wherein the evanescent wave phenomenon comprises surface plasmon resonance (SPR) claim 1 , and the sample surface comprises a material that exhibits SPR.4. A system according to claim 1 , wherein the illumination sub-system is configured to illuminate all sensing areas of interest simultaneously.5. A system according to claim 1 , wherein claim 1 , for each sensing area of interest claim 1 , the illumination sub-system is configured to illuminate said sensing area of interest over the entire range of angles of incidence simultaneously.6. A system according to claim 1 , wherein the detector comprises a plurality of detector elements claim 1 , and the different response of the detector to light received at different locations is due to a different response of the detector to light received by different detector elements.7. A system according to claim 6 , configured so that light reflected from each sensing area of interest claim 6 , at different angles of incidence in the range for that area claim 6 , is received by the elements of the detector with substantially different distributions of intensities claim 6 , thereby making it possible to determine claim 6 , from the response of the detector claim 6 , how much light is reflected from each sensing area of interest claim 6 , as a function of angle of incidence.8. A system according to claim 7 , wherein the projection optics projects light reflected from each sensing area of interest claim 7 , within each of a plurality of sub-ranges of ...

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Номер записи: 93

23-01-2014 дата публикации

Rotating stall detection using optical measurement of blade untwist

Номер: US20140023498A1

Автор: Daniel Kominsky

Принадлежит: Prime Photonics LC

Systems and methods are provided for real-time detection of the onset of stall in turbomachinery, such as compressor stall. The methods are capable of detecting and analyzing time of arrival of the chord of the blade at a sensor array to provide an indication of the onset of compressor stall. Systems for detecting the onset of compressor stall include: light sources; a plurality of linearly arranged optical fibers for transmitting light from the light sources and for receiving transmitted light reflected from a blade; a detector for measuring intensity of the reflected light; and a processor for analyzing the intensity of the reflected light to determine blade twist angle and from the blade twist angle identify onset of compressor stall. The invention can prevent the needless loss of life and assets caused by compressor stall that may lead to unexpected catastrophic failure of an engine.

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Номер записи: 94

23-01-2014 дата публикации

Flow-channel device for detecting light emission

Номер: US20140024126A1

Автор: Makoto Ogusu

Принадлежит: Canon Inc

The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove.

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Номер записи: 95

13-02-2014 дата публикации

METHOD AND APPARATUS FOR PROVIDING IMAGE DATA FOR CONSTRUCTING AN IMAGE OF A REGION OF A TARGET OBJECT

Номер: US20140043616A1

Автор: Humphry Martin James, Maiden Andrew Michael

Принадлежит: PHASE FOCUS LIMITED

Embodiments of the present invention provide a method () of providing image data for constructing an image of a region of a target object, comprising detecting, by at least one detector (), at least a portion of radiation scattered by a target object () with the incident radiation () or an aperture at a predetermined probe position, determining an offset vector () for reducing an error associated with the probe position (), estimating a wavefront () based on a probe function having the offset vector applied to the probe position, and providing image data responsive to the detected radiation. 1. A method of providing image data for constructing an image of a region of a target object , comprising:detecting, by at least one detector, at least a portion of radiation scattered by the target object with the incident radiation or an aperture at a predetermined probe position;determining an offset vector for reducing an error associated with the probe position;estimating a wavefront based on a probe function having the offset vector applied to the probe position; andproviding image data responsive to the detected radiation.2. The method of claim 1 , comprising:updating a current best offset vector associated with the probe position when a current best error metric associated with the probe position is improved.3. The method of claim 2 , wherein the updating of the current best offset vector comprises:determining an error metric for the offset vector based on a difference between the estimated wavefront and a wavefront corresponding to the radiation detected by the at least one detector; andcomparing the error metric for the offset vector with the current best error metric associated with a current best offset vector for the probe position.4. The method of claim 1 , comprising:determining an offset vector for each of a plurality of probe positions.5. The method of claim 1 , wherein the offset vector is determined in an at least partly random manner.6. The method of claim 1 ...

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Номер записи: 96

20-02-2014 дата публикации

MICROREACTOR FOR PHOTOREACTIONS

Номер: US20140050630A1

Автор: ASANO Yukako, Togashi Shigenori

Принадлежит: Hitachi, Ltd.

A microreactor for photoreactions includes a housing upper part, a lid plate made of a material that allows transmission of light, a flow path plate made of a material that suppresses light reflection and has a high thermal conductivity, and a housing lower part. Light is applied through a window of the housing upper part and the lid plate to a flow path of the flow path plate. The lid plate made of the material that allows transmission of light and the flow path plate made of the material that suppresses light reflection and has a high thermal conductivity are welded each other to form an integrated body. 1. A microreactor for photoreactions to proceed a photoreaction of a reactant or a plurality of reactants comprising:a flow path plate on which a flow path for passing the reactant or a plurality of reactants is formed, wherein the flow path plate is made of a material having a high thermal conductivity and suppressing light reflection.2. The microreactor for photoreactions according to claim 1 , whereinthe light reflectance of the flow path plate is 5.1% to 15.3% at a wavelength of light of 240 to 2600 nm.3. The microreactor for photoreactions according to claim 2 , whereinthe thermal conductivity of the flow path plate is 31.2 (W/(m·K)).4. The microreactor for photoreactions according to claim 3 , comprisinga lid plate made of a light transmitting material to be secured with the flow path plate in which the lid plate has a fluid inlet and a fluid exit formed at positions corresponding to a fluid inlet and a fluid exit formed to the flow path plate respectively.5. The microreactor for photoreactions according to claim 4 , comprising a housing upper part and a housing lower part for putting and fixing the lid plate and the flow path plate therebetween claim 4 , in which a fluid inlet and a fluid exit are formed to the housing upper part at positions corresponding to the fluid inlet and the fluid exit of the lid plate respectively.6. A microreactor device for ...

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Номер записи: 97

27-02-2014 дата публикации

DISPOSABLE SENSOR HEAD AND DISPOSABLE CONTAINER

Номер: US20140054186A1

Автор: Grimm Christian, Riechers Daniel

Принадлежит: SARTORIUS STEDIM BIOTECH GMBH

A disposable sensor head for an optical sensor has a central body () with an axial through-channel () closed by a transparent viewing disk () oriented transversely with respect to its longitudinal direction, and a circumferential fastening flange (), by which the central body is fastenable in a sealing fashion on a wall of a flexible container () so that the through-channel () passes through the wall. The through-channel () forms in one section an open flow chamber () that is bounded on one side by the viewing disk () and on the other side by a reflector disk () arranged opposite the viewing disk (). 112. A disposable sensor head for an optical sensor , comprising a central body () having{'b': 20', '14, 'an axial through-channel () closed by a transparent viewing disk () oriented transversely with respect to its longitudinal direction, and'}{'b': 22', '62', '20, 'claim-text': wherein', {'b': 20', '34', '14', '16', '14, 'the through-channel () forms in one section an open flow chamber (), that is bounded on one side by the viewing disk () and on the other side by a reflector disk () arranged opposite the viewing disk ().'}], 'a circumferential fastening flange (), by which the central body is fastenable in a sealing fashion on a wall of a flexible container () in such a way that the through-channel () passes through the wall,'}2. The sensor head of claim 1 ,wherein{'b': 34', '36', '14', '16, 'the flow chamber () comprises at least two lateral openings () arranged between the viewing disk () and the reflector disk ().'}3. The sensor head of claims 1 ,wherein{'b': 12', '14', '16', '25', '40, 'the central body () comprises, on a side of the viewing disk () facing away from the reflector disk (), a coupling device () for reversible coupling of an optoelectronic sensor module ().'}4. The sensor head of claims 1 ,wherein{'b': 12', '18', '24', '26, 'the central body () is constructed in a plurality of parts and comprises a main body () and at least one further central body ...

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Номер записи: 98

06-03-2014 дата публикации

FLOW CELL

Номер: US20140063494A1

Автор: HATAHORI Takahide, MORIYA Naoji, NAKAMA Yuji, WADA Yukihisa

Принадлежит:

In a flow cell, where a light introducing member for introducing light for measurement into a linear capillary through which sample liquid flows is attached to one end of the capillary, and a light leading out member for leading light transmitted through the capillary while transmitting through the sample liquid flowing through the capillary out to the outside is attached to the other end, the light introducing member is a light waveguide inserted into the capillary, and the light leading out member is a window member attached to an opening at the other end of the capillary so the loss of the amount of light transmitted through the capillary can be suppressed, while it is possible for flow cells of which the optical path has a different length to be attached without causing a problem relating to the positional relationships in the optical system, such as an absorbance detector. 1. A flow cell , comprising: a linear capillary through which a sample liquid flows; a light introducing member for introducing light for measurement into the capillary , the light introducing member being attached to one end of the capillary; and a light leading out member for leading light that has transmitted through the capillary while transmitting through the sample liquid flowing through the capillary out to the outside , the light leading out member being attached to the other end of the capillary , and being characterized in thatsaid light introducing member is a light waveguide inserted into the capillary through an opening at one end of said capillary, and said light leading out member is a window member attached to an opening at the other end of the capillary.2. The flow cell according to claim 1 , characterized in that said light waveguide is an optical fiber without an outer coating or a quartz cylinder.3. The flow cell according to claim 1 , characterized in that a quartz convex lens is provided in the end portion of said light waveguide on the light source side.4. The flow cell ...

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Номер записи: 99

13-03-2014 дата публикации

Microfluidic photoporation

Номер: US20140073027A1

Автор: Frank Gunn-Moore, Kishan Dholakia, Robert Marchington, Yoshihiko Arita

Принадлежит: University of St Andrews

A cell permeabilizing micro fluidic system for permeabilizing one or more cells in a fluid flow. The system has a micro fluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.

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Номер записи: 100